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2,216 results on '"Fagard, R."'

107. Hypertension in Elderly

Author

Forette, F., Henry, J. F., Hervy, M. P., Fagard, R., Lijnen, P., Staessen, J., Amery, A., Amery, A., editor, Fagard, R., editor, Lijnen, P., editor, and Staessen, J., editor

Published
1982
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115. Effects of blood pressure lowering on cardiovascular risk according to baseline body-mass index: A meta-analysis of randomised trials

Author

Agodoa, L, Estacio, R, Schrier, R, Lubsen, J, Chalmers, J, Cutler, J, Davis, B, Wing, L, Poulter, N, Sever, P, Remuzzi, G, Ruggenenti, P, Nissen, S, Lindholm, L, Fukui, T, Ogihara, T, Saruta, T, Black, H, Sleight, P, Lievre, M, Suzuki, H, Fox, K, Lisheng, L, Ohkubo, T, Imai, Y, Yusuf, S, Bulpitt, C, Lewis, E, Brown, M, Palmer, C, Wang, J, Pepine, C, Ishii, M, Yui, Y, Kuramoto, K, Pfeff Er, M, Asselbergs, F, Van Gilst, W, Byington, B, Pitt, B, Brenner, B, Remme, W, De Zeeuw, D, Rahman, M, Viberti, G, Teo, K, Zanchetti, A, Malacco, E, Mancia, G, Staessen, J, Fagard, R, Holman, R, Hansson, L, Kostis, J, Kanno, Y, Lueders, S, Matsuzaki, M, Poole-Wilson, P, Schrader, J, Rahimi, K, Anderson, C, Chapman, N, Collins, R, Macmahon, S, Neal, B, Rodgers, A, Whelton, P, Woodward, M, Agodoa L., Estacio R., Schrier R., Lubsen J., Chalmers J., Cutler J., Davis B., Wing L., Poulter N. R., Sever P., Remuzzi G., Ruggenenti P., Nissen S., Lindholm L. H., Fukui T., Ogihara T., Saruta T., Black H., Sleight P., Lievre M., Suzuki H., Fox K., Lisheng L., Ohkubo T., Imai Y., Yusuf S., Bulpitt C. J., Lewis E., Brown M., Palmer C., Wang J., Pepine C., Ishii M., Yui Y., Kuramoto K., Pfeff Er M., Asselbergs F. W., Van Gilst W. H., Byington B., Pitt B., Brenner B., Remme W. J., De Zeeuw D., Rahman M., Viberti G., Teo K., Zanchetti A., Malacco E., Mancia G., Staessen J., Fagard R., Holman R., Hansson L., Kostis J., Kanno Y., Lueders S., Matsuzaki M., Poole-Wilson P., Schrader J., Rahimi K., Anderson C., Chapman N., Collins R., MacMahon S., Neal B., Rodgers A., Whelton P., Woodward M., Agodoa, L, Estacio, R, Schrier, R, Lubsen, J, Chalmers, J, Cutler, J, Davis, B, Wing, L, Poulter, N, Sever, P, Remuzzi, G, Ruggenenti, P, Nissen, S, Lindholm, L, Fukui, T, Ogihara, T, Saruta, T, Black, H, Sleight, P, Lievre, M, Suzuki, H, Fox, K, Lisheng, L, Ohkubo, T, Imai, Y, Yusuf, S, Bulpitt, C, Lewis, E, Brown, M, Palmer, C, Wang, J, Pepine, C, Ishii, M, Yui, Y, Kuramoto, K, Pfeff Er, M, Asselbergs, F, Van Gilst, W, Byington, B, Pitt, B, Brenner, B, Remme, W, De Zeeuw, D, Rahman, M, Viberti, G, Teo, K, Zanchetti, A, Malacco, E, Mancia, G, Staessen, J, Fagard, R, Holman, R, Hansson, L, Kostis, J, Kanno, Y, Lueders, S, Matsuzaki, M, Poole-Wilson, P, Schrader, J, Rahimi, K, Anderson, C, Chapman, N, Collins, R, Macmahon, S, Neal, B, Rodgers, A, Whelton, P, Woodward, M, Agodoa L., Estacio R., Schrier R., Lubsen J., Chalmers J., Cutler J., Davis B., Wing L., Poulter N. R., Sever P., Remuzzi G., Ruggenenti P., Nissen S., Lindholm L. H., Fukui T., Ogihara T., Saruta T., Black H., Sleight P., Lievre M., Suzuki H., Fox K., Lisheng L., Ohkubo T., Imai Y., Yusuf S., Bulpitt C. J., Lewis E., Brown M., Palmer C., Wang J., Pepine C., Ishii M., Yui Y., Kuramoto K., Pfeff Er M., Asselbergs F. W., Van Gilst W. H., Byington B., Pitt B., Brenner B., Remme W. J., De Zeeuw D., Rahman M., Viberti G., Teo K., Zanchetti A., Malacco E., Mancia G., Staessen J., Fagard R., Holman R., Hansson L., Kostis J., Kanno Y., Lueders S., Matsuzaki M., Poole-Wilson P., Schrader J., Rahimi K., Anderson C., Chapman N., Collins R., MacMahon S., Neal B., Rodgers A., Whelton P., and Woodward M.

Abstract

Summary Background The cardiovascular benefits of blood pressure lowering in obese people compared with people of normal weight might depend on choice of drug. We compared the effects of blood pressure-lowering regimens on cardiovascular risk in groups of patients categorised by baseline body-mass index (BMI). Methods We used individual patient data from trials included in the Blood Pressure Lowering Treatment Trialists' Collaboration to compare the effects of different classes of blood pressure-lowering regimens for the primary outcome of total major cardiovascular events (stroke, coronary heart disease, heart failure, and cardiovascular death). We used meta-analyses and meta-regressions to assess interactions between treatment and BMI when fitted as either a categorical variable (<25 kg/m2, 25 to <30 kg/m2, and ≥30 kg/m2) or a continuous variable. Findings Analyses were based on 135 715 individuals from 22 trials who had 14 353 major cardiovascular events. None of the six primary comparisons showed evidence that protection varied by drug class across the three BMI groups (all p for trend >0·20). When analysed as a continuous variable, angiotensin-converting-enzyme inhibitors gave slightly greater protection for each 5 kg/m2 higher BMI than did calcium antagonists (hazard ratio 0·93, 95% CI 0·89-0·98; p=0·004) or diuretics (0·93, 0·89-0·98; p=0·002). The meta-regressions showed no relation between BMI category and the risk reduction for a given fall in systolic blood pressure. By contrast with a previous report, we noted no relation between BMI and the efficacy of calcium antagonists compared with diuretics. Interpretation We found little evidence that selection of a particular class of blood pressure-lowering drug will lead to substantially different outcomes for individuals who are obese compared with those who are lean. Funding None.

Published
2015

118. Investigating the stratified efficacy and safety of pharmacological blood pressure-lowering: an overall protocol for individual patient-level data meta-analyses of over 300 000 randomised participants in the new phase of the Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC)

Author

Rahimi, K, Canoy, D, Nazarzadeh, M, Salimi-Khorshidi, G, Woodward, M, Teo, K, Davis, BR, Chalmers, J, Pepine, CJ, Agodoa, L, Algra, A, Asselbergs, FW, Beckett, N, Berge, E, Black, H, Brouwers, FPJ, Brown, M, Bulpitt, CJ, Byington, B, Cutler, J, Devereaux, RB, Dwyer, D, Fagard, R, Fox, K, Fukui, T, Gupta, AJ, Holman, RR, Imai, Y, Ishii, M, Julius, S, Kanno, Y, Kjeldsen, SE, Kostis, J, Kuramoto, K, Lanke, J, Lewis, E, Lievre, M, Lindholm, LH, Lueders, S, MacMahon, S, Matsuzaki, M, Mehlum, MH, Nissen, S, Ogawa, H, Othisgihara, T, Ohkubo, T, Palmer, C, Patel, A, Pepine, C, Pfeffer, M, Poulter, NR, Rakugi, H, Remuzzi, G, Ruggenenti, P, Saruta, T, Schrader, J, Schrier, R, Sever, P, Sleight, P, Staessen, JA, Suzuki, H, Thijs, L, Ueshima, K, Umemoto, S, Van Gilst, WH, Verdecchia, P, Wachtell, K, Yui, Y, Yusuf, S, Baigent, C, Collins, R, De Zeeuw, D, Neal, B, Perkovic, V, Rahman, M, Remme, WJ, Rodgers, A, Sundstrom, J, Turnbull, F, Foundation for Circulatory Health, Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), and Staessen, Jan

Subjects
medicine.medical_specialty, Epidemiology, Disease, REGIMENS, 030204 cardiovascular system & hematology, Research Support, Phase (combat), 03 medical and health sciences, Medicine, General & Internal, 0302 clinical medicine, General & Internal Medicine, Diabetes mellitus, Protocol, medicine, Journal Article, Humans, 030212 general & internal medicine, Intensive care medicine, Non-U.S. Gov't, Stroke, Antihypertensive Agents, Randomized Controlled Trials as Topic, RISK, Protocol (science), Medicine(all), Science & Technology, efficacy and safety of bp lowering treatment, HYPERTENSION, business.industry, Research Support, Non-U.S. Gov't, blood pressure, General Medicine, medicine.disease, PROSPECTIVELY-DESIGNED OVERVIEWS, MODEL, Treatment Outcome, MAJOR CARDIOVASCULAR EVENTS, Blood pressure, Patient level data, meta-analyses, Blood pressure lowering, business, Life Sciences & Biomedicine, Blood Pressure Lowering Treatment Trialists’ Collaboration
Abstract

IntroductionPrevious research from the Blood Pressure Lowering Treatment Trialists’ Collaboration (BPLTTC) and others has shown that pharmacological blood pressure (BP)- lowering substantially reduces the risk of major cardiovascular events, including ischaemic heart disease, heart failure and stroke. In this new phase, the aim is to conduct individual patient-level data (IPD) meta-analyses involving eligible BP-lowering randomised controlled trials (RCTs) to address uncertainties relating to efficacy and safety of BP-lowering treatment.Methods and analysisRCTs investigating the effect of pharmacological BP-lowering, with a minimum of 1000 patient-years of follow-up in each trial arm, are eligible. Our systematic review identified 100 potentially eligible trials. We requested their investigators/sponsors to contribute baseline, follow-up and outcomes data. As of June 2018, the collaboration has obtained data from 49 trials (n=315 046 participants), with additional data currently in the process of being transferred from four RCTs (n=34 642 participants). In addition, data harmonisation has commenced. Scientific activities of the collaboration are overseen by the Steering Committee with input from all collaborators. Detailed protocols for individual meta-analyses will be developed and registered on public platforms.Ethics and disseminationEthics approval has been obtained for this new and extended phase of the BPLTTC, the largest collaboration of de-identified IPD from RCTs. It offers an efficient and ethical manner of re-purposing existing data to answer clinically important questions relating to BP treatment as well as methodological questions relating to IPD meta-analyses. Among the immediate impacts will include reliable quantification of effects of treatment modifiers, such as baseline BP, age and prior disease, on both vascular and non-vascular outcomes. Analyses will further assess the impact of BP-lowering on important, but less well understood, outcomes, such as new-onset diabetes and renal disease. Findings will be published in peer-reviewed medical journals on behalf of the collaboration.

Published
2019

119. 2007 ESH‐ESC Guidelines for the management of arterial hypertension

Author

Mancia, G., DE BACIKER, G., Dominiczak, A., Cifikova, R., Fagard, R., Germano', Giuseppe Italo Walter, Grassi, G., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., Narkiewicz, K., Ruilope, L., Rynikiewicz, . A., Schmieder, R. E., STRUIJKER BOUDIER, H. A., ZANCHETTIi EUROPEAN SOCIETY OF HYPERTENSION, . A., EUROPEAN SOCIETY OF CARDIOLOGY, Mancia, G, De Backer, G, Dominiczak, A, Cifkova, R, Fagard, R, Germano, G, Grassi, G, Heagerty, A, Kjeldsen, S, Laurent, S, Narkiewicz, K, Ruilope, L, Rynkiewicz, A, Schmieder, R, Boudier, H, and Zanchetti, A

Subjects
arterial hypertension, medicine.medical_specialty, Ambulatory blood pressure, Risk Factors, Internal Medicine, Humans, Medicine, Hypertension diagnosis, Antihypertensive Agents, Evidence-Based Medicine, Task force, business.industry, General Medicine, Target organ damage, Coronary heart disease, monitoring, Intima-media thickness, Hypertension complications, Hypertension, Isolated systolic hypertension, Emergency medicine, Guidelines BP control, MED/09 - MEDICINA INTERNA, Cardiology and Cardiovascular Medicine, business, Risk Reduction Behavior
Published
2007

120. 2014 ESC guidelines on the diagnosis and treatment of aortic diseases

Author

Erbel R, Aboyans, V, Boileau C, Bossone E, Di Bartolomeo R, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwöger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, von Allmen RS, Vrints CJM, European Society of Cardiology (ESC), Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol Ç, Fagard R, Ferrari R, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S., Erbel, R, Aboyans, V, Boileau, C, Bossone, E, Di Bartolomeo, R, Eggebrecht, H, Evangelista, A, Falk, V, Frank, H, Gaemperli, O, Grabenwöger, M, Haverich, A, Iung, B, Manolis, Aj, Meijboom, F, Nienaber, Ca, Roffi, M, Rousseau, H, Sechtem, U, Sirnes, Pa, von Allmen, R, Vrints, Cjm, European Society of Cardiology, (ESC), Zamorano, Jl, Achenbach, S, Baumgartner, H, Bax, Jj, Bueno, H, Dean, V, Deaton, C, Erol, Ç, Fagard, R, Ferrari, R, Hasdai, D, Hoes, A, Kirchhof, P, Knuuti, J, Kolh, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, Mf, Ponikowski, P, Tamargo, Jl, Tendera, M, Torbicki, A, Wijns, W, and Windecker, S.

Published
2015

121. 2003 European Society of Hypertension???European Society of Cardiology guidelines for the management of arterial hypertension*

Author

MANCIA, GIUSEPPE, Rosei, EA, Cifkova, R, DeBacker, G, Erdine, S, Fagard, R, Farsang, C, Heagerty, AM, Kawecka Jaszcs, K, Kiowski, W, Kjeldsen, S, Luscher, T, McInnes, G, Mallion, JM, Brien, EO, Poulter, NR, Priori, SG, Rahn, KH, Rodicio, JL, Ruilope, LM, Safar, M, Staessen, JA, van Zwieten, P, Waeber, B, Williams, B, Zanchetti, A, Zannad, F., Mancia, G, Rosei, E, Cifkova, R, Debacker, G, Erdine, S, Fagard, R, Farsang, C, Heagerty, A, Kawecka Jaszcs, K, Kiowski, W, Kjeldsen, S, Luscher, T, Mcinnes, G, Mallion, J, Brien, E, Poulter, N, Priori, S, Rahn, K, Rodicio, J, Ruilope, L, Safar, M, Staessen, J, van Zwieten, P, Waeber, B, Williams, B, Zanchetti, A, and Zannad, F

Subjects
Physiology, optimal treatment hot, left-ventricular hypertrophy, end-point reduction, target-organ damage, Blood Pressure Determination, Guideline, Clinical practice, isolated systolic hypertension, Risk Assessment, Europe, ambulatory blood-pressure, randomized controlled trial, Hypertension, Internal Medicine, Humans, MED/09 - MEDICINA INTERNA, coronary-heart-disease, intima-media thickness, Cardiology and Cardiovascular Medicine, Risk Reduction Behavior, converting-enzyme-inhibition, Antihypertensive Agents
Abstract

ispartof: Journal of hypertension vol:21 issue:6 pages:1011-1053 ispartof: location:Netherlands status: published

Published
2003

123. ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

Author

Rydén, L, Grant, Pj, Anker, Sd, Berne, C, Cosentino, F, Danchin, N, Deaton, C, Escaned, J, Hammes, Hp, Huikuri, H, Marre, M, Marx, N, Mellbin, L, Ostergren, J, Patrono, C, Seferovic, P, Uva, Ms, Taskinen, Mr, Tendera, M, Tuomilehto, J, Valensi, P, Zamorano, Jl, Achenbach, S, Baumgartner, H, Bax, Jj, Bueno, H, Dean, V, Erol, C, Fagard, R, Ferrari, R, Hasdai, D, Hoes, Aw, Kirchhof, P, Knuuti, J, Kolh, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, Mf, Ponikowski, P, Sirnes, Pa, Tamargo, Jl, Torbicki, A, Wijns, W, Windecker, S, De Backer, G, Ezquerra, Ea, Avogaro, Angelo, Badimon, L, Baranova, E, Betteridge, J, Ceriello, A, Funck Brentano, C, Gulba, Dc, Kjekshus, Jk, Lev, E, Mueller, C, Neyses, L, Nilsson, Pm, Perk, J, Reiner, Z, Sattar, N, Schächinger, V, Scheen, A, Schirmer, H, Strömberg, A, Sudzhaeva, S, Viigimaa, M, Vlachopoulos, C, Xuereb, Rg, Authors/Task Force Members, ESC Committee for Practice Guidelines, and Document, Reviewers

Subjects
Male, Epidemiology, Smoking Prevention, Impaired glucose tolerance, Diabetes mellitus, Patient-Centered Care, Medicine, Child, Diagnostics, Smoking, Middle Aged, Cardiovascular disease, Prognosis, Patient management, Coronary Interventions, Cardiovascular Diseases, Pre diabetes, Child, Preschool, Female, Cardiology and Cardiovascular Medicine, Pharmacological treatment, Adult, medicine.medical_specialty, Adolescent, 610 Medicine & health, Guidelines, Prediabetic State, Young Adult, Internal medicine, Humans, Exercise, Aged, Glycated Hemoglobin, business.industry, Task force, Prevention, Settore MED/09 - MEDICINA INTERNA, Infant, medicine.disease, Diet, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Risk factors, business, Diabetic Angiopathies
Published
2013

140. 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy:the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC)

Author

Elliott P. M., Anastasakis A., Borger M. A., Borggrefe M., Cecchi F., Charron P., Hagege A. A., Lafont A., Limongelli G., Mahrholdt H., McKenna W. J., Mogensen J., Nihoyannopoulos P., Nistri S., Piepe P. G., Pieske B., Rapezzi C., Rutten F. H., Tillmanns C., Watkins H., O'Mahony C., Achenbach S., Baumgartner H., Bax J. J., Bueno H., Dean V., Deaton C., Erol C., Fagard R., Ferrari R., Hasdai D., Hoes A. W., Kirchhof P., Knuuti J., Kolh P., Lancellotti P., Linhart A., Piepoli M. F., Ponikowski P., Sirnes P. A., Tamargo J. L., Tendera M., Torbicki A., Wijns W., Windecker S., Alfonso F., Basso C., Cardim N. M., Gimeno J. R., Heymans S., Holm P. J., Keren A., Lionis C., Muneretto C., Priori S., Salvador M. J., Wolpert C., MUMC+: MA Med Staf Spec Cardiologie (9), Cardiologie, RS: CARIM - R2 - Cardiac function and failure, Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagege, A. A., Lafont, A., Limongelli, G., Mahrholdt, H., Mckenna, W. J., Mogensen, J., Nihoyannopoulos, P., Nistri, S., Piepe, P. G., Pieske, B., Rapezzi, C., Rutten, F. H., Tillmanns, C., Watkins, H., O'Mahony, C., Achenbach, S., Baumgartner, H., Bax, J. J., Bueno, H., Dean, V., Deaton, C., Erol, C., Fagard, R., Ferrari, R., Hasdai, D., Hoes, A. W., Kirchhof, P., Knuuti, J., Kolh, P., Lancellotti, P., Linhart, A., Piepoli, M. F., Ponikowski, P., Sirnes, P. A., Tamargo, J. L., Tendera, M., Torbicki, A., Wijns, W., Windecker, S., Alfonso, F., Basso, C., Cardim, N. M., Gimeno, J. R., Heymans, S., Holm, P. J., Keren, A., Lionis, C., Muneretto, C., Priori, S., Salvador, M. J., and Wolpert, C.

Subjects
Ablation Techniques, Arrhythmia, Athletes, Cardiac imaging, Diagnosis, Genetics, Guideline, Heart failure, Hypertension, Implantable cardioverter defibrillators, Left ventricular outflow tract obstruction, Pregnancy, Sudden cardiac death, Symptoms, Valve disease, Cardiomyopathy, Heart Valve Diseases, Adult, Angina Pectoris, Arrhythmias, Cardiac, Cardiac Imaging Techniques, Cardiac Pacing, Artificial, Hypertrophic, Child, Clinical Laboratory Techniques, Death, Sudden, Delivery of Health Care, Differential, Electrocardiography, Female, Genetic Counseling, Genetic Testing, Heart Failure, Humans, Medical History Taking, Pedigree, Physical Examination, Preconception Care, Pregnancy Complications, Cardiovascular, Prenatal Care, Risk Factors, Sports Medicine, Syncope, Thoracic Surgical Procedures, Ventricular Outflow Obstruction, Cardiology and Cardiovascular Medicine, Thoracic Surgical Procedure, Clinical Laboratory Technique, Implantable cardioverter defibrillator, Ablation Technique, Angina Pectori, Hypertrophic cardiomyopathy, Cardiac Pacing, Artificial, Heart Valve Disease, Cardiology, Diagnosi, Human, Alcohol septal ablation, medicine.medical_specialty, Genetic counseling, Symptom, Pregnancy Complications, Cardiovascular, 610 Medicine & health, NO, Diagnosis, Differential, Athlete, Genetic, Internal medicine, medicine, Guidline, Intensive care medicine, ta3126, Cardiac Imaging Technique, business.industry, Risk Factor, Arrhythmias, Cardiac, Cardiomyopathy, Hypertrophic, medicine.disease, Septal myectomy, Death, Sudden, Cardiac, business
Published
2014

141. Blood pressure lowering and major cardiovascular events in people with and without chronic kidney disease: meta-analysis of randomised controlled trials

Author

Agodoa, L, Anderson, C, Asselbergs, FW, Baigent, C, Black, H, Brenner, B, Brown, M, Bulpitt, C, Byington, R, Chalmers, J, Collins, R, Cutler, J, Dahlof, B, Davis, B, de Zeeuw, D, Dens, J, Estacio, R, Fagard, R, Fox, K, Fukui, T, Hansson, L, Holman, R, Hunsicker, L, Imai, Y, Ishii, M, Kanno, Y, Kostis, J, Kuramoto, K, Lewis, E, Lievre, M, Lindholm, LH, Liu, L, Lubsen, J, Lueders, S, MacMahon, S, Malacco, E, Mancia, G, Matsuzaki, M, Neal, B, Nissen, S, Ohkubo, T, Ogihara, T, Pepine, C, Pfeffer, M, Pitt, B, Poole-Wilson, P, Poulter, N, Rahman, M, Remme, W, Remuzzi, G, Rodgers, A, Ruggenenti, P, Saruta, T, Schrader, J, Schrier, R, Sever, P, Sleight, P, Staessen, J, Suzuki, H, Teo, K, van Gilst, WH, Viberti, G, Wang, J, Whelton, P, Wing, L, Yui, Y, Yusuf, S, Zanchetti, A, Barzi, F, Heritier, S, Li, N, Ninomiya, T, Perkovic, V, Turnbull, F, Woodward, M, Wilson, K, Kearney, ACP, Gallagher, M, Cass, A, Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Cardiology, Clinical Research Unit, Pathology, Graduate School, ACS - Heart failure & arrhythmias, and Amsterdam Reproduction & Development (AR&D)

Subjects
medicine.medical_specialty, Hemodynamics, Renal function, CONVERTING ENZYME-INHIBITOR, PLACEBO-CONTROLLED TRIAL, CALCIUM-ANTAGONIST, DOUBLE-BLIND, HYPERTENSIVE PATIENTS, RISK-FACTOR, Internal medicine, medicine, Myocardial infarction, Intensive care medicine, PUBLICATION BIAS, biology, business.industry, Research, Angiotensin-converting enzyme, General Medicine, medicine.disease, RENAL OUTCOMES, Blood pressure, ATHEROSCLEROSIS, Heart failure, Cardiology, Aortic pressure, biology.protein, CORONARY-ARTERY-DISEASE, business, Kidney disease
Abstract

Objective To define the cardiovascular effects of lowering blood pressure in people with chronic kidney disease.Design Collaborative prospective meta-analysis of randomised trials.Data sources and eligibility Participating randomised trials of drugs to lower blood pressure compared with placebo or each other or that compare different blood pressure targets, with at least 1000 patient years of follow-up per arm.Main outcome measures Major cardiovascular events (stroke, myocardial infarction, heart failure, or cardiovascular death) in composite and individually and all cause death.Participants 26 trials (152 290 participants), including 30 295 individuals with reduced estimated glomerular filtration rate (eGFR), which was defined as eGFRData extraction Individual participant data were available for 23 trials, with summary data from another three. Meta-analysis according to baseline kidney function was performed. Pooled hazard ratios per 5 mm Hg lower blood pressure were estimated with a random effects model.Results Compared with placebo, blood pressure lowering regimens reduced the risk of major cardiovascular events by about a sixth per 5 mm Hg reduction in systolic blood pressure in individuals with (hazard ratio 0.83, 95% confidence interval 0.76 to 0.90) and without reduced eGFR (0.83, 0.79 to 0.88), with no evidence for any difference in effect (P=1.00 for homogeneity). The results were similar irrespective of whether blood pressure was reduced by regimens based on angiotensin converting enzyme inhibitors, calcium antagonists, or diuretics/beta blockers. There was no evidence that the effects of different drug classes on major cardiovascular events varied between patients with different eGFR (all P>0.60 for homogeneity).Conclusions Blood pressure lowering is an effective strategy for preventing cardiovascular events among people with moderately reduced eGFR. There is little evidence from these overviews to support the preferential choice of particular drug classes for the prevention of cardiovascular events in chronic kidney disease.

Published
2016

142. Erratum: 'European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)' the Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts)

Author

Perk, J, De Backer, G, Gohlke, H, Graham, I, Reiner, Z, Verschuren, WMM, Albus, C, Benlian, P, Boysen, G, Cifkova, R, Deaton, C, Ebrahim, S, Fisher, M, Germano, G, Hobbs, R, Hoes, A, Karadeniz, S, Mezzani, A, Prescott, E, Ryden, L, Scherer, M, Syvänne, M, Scholte Op Reimer, WJ, Vrints, C, Wood, D, Zamorano, JL, Zannad, F, Cooney, MT, Bax, J, Baumgartner, H, Ceconi, C, Dean, V, Fagard, R, Funck-Brentano, C, Hasdai, D, Kirchhof, P, Knuuti, J, Kolh, P, McDonagh, T, Moulin, C, Popescu, BA, Reiner, Ž, Sechtem, U, Sirnes, PA, Tendera, M, Torbicki, A, Vahanian, A, Windecker, S, Aboyans, V, Ezquerra, EA, Baigent, C, Brotons, C, Burell, G, Ceriello, A, De Sutter, J, Deckers, J, Del Prato, S, Diener, HC, Fitzsimons, D, Fras, Z, Hambrecht, R, Jankowski, P, Keil, U, Kirby, M, Larsen, ML, Mancia, G, Manolis, AJ, McMurray, J, Pajak, A, Parkhomenko, A, Rallidis, L, Rigo, F, Rocha, E, Ruilope, LM, Van Der Velde, E, Vanuzzo, D, Viigimaa, M, Volpe, M, Wiklund, O, and Wolpert, C

Subjects
Clinical Practice, medicine.medical_specialty, Rehabilitation, Cardiovascular prevention, Task force, business.industry, medicine.medical_treatment, Alternative medicine, medicine, Physical therapy, Disease prevention, Cardiology and Cardiovascular Medicine, business
Published
2016

143. Protocol for prospective collaborative overviews of major randomized trials of blood-pressure-lowering treatments. World Health Organization-International Society of Hypertension Blood Pressure Lowering Treatment Trialists' Collaboration

Author

Black, H, Boissel, J, Brenner, B, Brown, M, Bulpitt, C, Chalmers, J, Collins, R, Cutler, J, Dahlof, B, Davis, B, Fagard, R, Fletcher, A, Furberg, C, Hansson, L, Kuramoto, K, Lewis, E, MacMahon, S, Mancia, G, Pitt, B, Poulter, N, Remuzzi, G, Sleight, P, Turner, R, Sever, P, and Whelton, P

Abstract

OBJECTIVE: To conduct prospectively planned overviews (meta-analyses) of the ongoing randomized trials of blood-pressure-lowering drugs. These overviews should provide reliable data about the effects of newer classes of blood-pressure-lowering drugs (such as angiotensin converting enzyme inhibitors and calcium antagonists) on major causes of cardiovascular mortality and morbidity for a variety of patient groups. METHODS: A registry of major ongoing or planned randomized trials (with more than 1000 patient-years of follow-up for each randomized group) of blood-pressure-lowering agents has been established. The principal investigators of each of these studies have been invited to collaborate in the project and to provide, upon completion of the study, a limited data set for inclusion in the overview analyses. The principal comparisons will be of newer versus older classes of blood-pressure-lowering drugs in treating patients with hypertension and of newer blood-pressure-lowering treatments versus untreated or less treated control conditions for a variety of other groups of patients with a high risk of cardiovascular events. Separate analyses will be conducted for the main drug classes and for major subgroups of patients defined by characteristics such as age, gender, blood pressure, diabetes, and history of renal disease, coronary heart disease or cerebrovascular disease. The principal study outcomes are stroke, major coronary heart disease events, heart failure, total cardiovascular deaths, total cardiovascular events and total mortality. RESULTS: In total 36 trials of blood-pressure-lowering treatments potentially eligible for inclusion in this project have been identified and agreement to collaborate has been confirmed by the investigators in 30 trials, with collaboration pending for six recently identified studies. The first round of analyses will be conducted in 1999 and will be based on total cardiovascular events observed among a total of about 64,000 patients, involving about 240,000 patient-years of follow-up. The second round of analyses will be conducted in 2003 on data from at least 195,000 patients and 899,000 patient-years of follow-up. By that time it is estimated that a total of about 8000 strokes, 12,000 coronary heart disease events and 23,000 cardiovascular events in total will have occurred. This should provide good statistical power to detect even modest cause-specific differences in the incidence of the main study outcomes. CONCLUSIONS: The combination of trial results in prospectively planned, systematic overviews both reduces random errors and avoids biases. As a consequence, this project should provide more reliable information about the effects of newer blood-pressure-lowering drugs than would any one study alone. The use of data from individual patients in these overviews will facilitate investigation of the separate effects of various drug regimens in treating members of major patient subgroups.

Published
2016

146. 213 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy

Author

Brignole, M, Auricchio, A, Baron-Esquivias, G, Bordachar, P, Boriani, G, Breithardt, O, Cleland, J, Deharo, J, Delgado, V, Elliott, P, Gorenek, B, Israel, C, Leclercq, C, Linde, C, Mont, L, Padeletti, L, Sutton, R, Vardas, P, Zamorano, J, Achenbach, S, Baumgartner, H, Bax, J, Bueno, H, Dean, V, Deaton, C, Erol, C, Fagard, R, Ferrari, R, Hasdai, D, Hoes, A, Kirchhof, P, Knuuti, J, Kolh, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, M, Ponikowski, P, Sirnes, P, Tamargo, J, Tendera, M, Torbicki, A, Wijns, W, Windecker, S, Blomstrom-Lundqvist, C, Badano, L, Aliyev, F, Bansch, D, Bsata, W, Buser, P, Charron, P, Daubert, J, Dobreanu, D, Faerestrand, S, Le Heuzey, J, Mavrakis, H, Mcdonagh, T, Merino, J, Nawar, M, Nielsen, J, Pieske, B, Poposka, L, Ruschitzka, F, Wilson, C, Brignole M., Auricchio A., Baron-Esquivias G., Bordachar P., Boriani G., Breithardt O. -A., Cleland J., Deharo J. -C., Delgado V., Elliott P. M., Gorenek B., Israel C. W., Leclercq C., Linde C., Mont L., Padeletti L., Sutton R., Vardas P. E., Zamorano J. L., Achenbach S., Baumgartner H., Bax J. J., Bueno H., Dean V., Deaton C., Erol C., Fagard R., Ferrari R., Hasdai D., Hoes A. W., Kirchhof P., Knuuti J., Kolh P., Lancellotti P., Linhart A., Nihoyannopoulos P., Piepoli M. F., Ponikowski P., Sirnes P. A., Tamargo J. L., Tendera M., Torbicki A., Wijns W., Windecker S., Blomstrom-Lundqvist C., Badano L. P., Aliyev F., Bansch D., Bsata W., Buser P., Charron P., Daubert J. -C., Dobreanu D., Faerestrand S., Le Heuzey J. -Y., Mavrakis H., McDonagh T., Merino J. L., Nawar M. M., Nielsen J. C., Pieske B., Poposka L., Ruschitzka F., Wilson C. M., Brignole, M, Auricchio, A, Baron-Esquivias, G, Bordachar, P, Boriani, G, Breithardt, O, Cleland, J, Deharo, J, Delgado, V, Elliott, P, Gorenek, B, Israel, C, Leclercq, C, Linde, C, Mont, L, Padeletti, L, Sutton, R, Vardas, P, Zamorano, J, Achenbach, S, Baumgartner, H, Bax, J, Bueno, H, Dean, V, Deaton, C, Erol, C, Fagard, R, Ferrari, R, Hasdai, D, Hoes, A, Kirchhof, P, Knuuti, J, Kolh, P, Lancellotti, P, Linhart, A, Nihoyannopoulos, P, Piepoli, M, Ponikowski, P, Sirnes, P, Tamargo, J, Tendera, M, Torbicki, A, Wijns, W, Windecker, S, Blomstrom-Lundqvist, C, Badano, L, Aliyev, F, Bansch, D, Bsata, W, Buser, P, Charron, P, Daubert, J, Dobreanu, D, Faerestrand, S, Le Heuzey, J, Mavrakis, H, Mcdonagh, T, Merino, J, Nawar, M, Nielsen, J, Pieske, B, Poposka, L, Ruschitzka, F, Wilson, C, Brignole M., Auricchio A., Baron-Esquivias G., Bordachar P., Boriani G., Breithardt O. -A., Cleland J., Deharo J. -C., Delgado V., Elliott P. M., Gorenek B., Israel C. W., Leclercq C., Linde C., Mont L., Padeletti L., Sutton R., Vardas P. E., Zamorano J. L., Achenbach S., Baumgartner H., Bax J. J., Bueno H., Dean V., Deaton C., Erol C., Fagard R., Ferrari R., Hasdai D., Hoes A. W., Kirchhof P., Knuuti J., Kolh P., Lancellotti P., Linhart A., Nihoyannopoulos P., Piepoli M. F., Ponikowski P., Sirnes P. A., Tamargo J. L., Tendera M., Torbicki A., Wijns W., Windecker S., Blomstrom-Lundqvist C., Badano L. P., Aliyev F., Bansch D., Bsata W., Buser P., Charron P., Daubert J. -C., Dobreanu D., Faerestrand S., Le Heuzey J. -Y., Mavrakis H., McDonagh T., Merino J. L., Nawar M. M., Nielsen J. C., Pieske B., Poposka L., Ruschitzka F., and Wilson C. M.

Published
2013

147. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation

Author

Steg, P, James, S, Atar, D, Badano, L, Lundqvist, C, Borger, M, Di Mario, C, Dickstein, K, Ducrocq, G, Fernandez-Aviles, F, Gershlick, A, Giannuzzi, P, Halvorsen, S, Huber, K, Juni, P, Kastrati, A, Knuuti, J, Lenzen, M, Mahaffey, K, Valgimigli, M, Van'T Hof, A, Widimsky, P, Zahger, D, Bax, J, Baumgartner, H, Ceconi, C, Dean, V, Deaton, C, Fagard, R, Funck-Brentano, C, Hasdai, D, Hoes, A, Kirchhof, P, Kolh, P, Mcdonagh, T, Moulin, C, Popescu, B, Reiner, Z, Sechtem, U, Sirnes, P, Tendera, M, Torbicki, A, Vahanian, A, Windecker, S, Astin, F, Astrom-Olsson, K, Budaj, A, Clemmensen, P, Collet, J, Fox, K, Fuat, A, Gustiene, O, Hamm, C, Kala, P, Lancellotti, P, Maggioni, A, Merkely, B, Neumann, F, Piepoli, M, Van De Werf, F, Verheugt, F, Wallentin, L, Steg P. G., James S. K., Atar D., Badano L., Lundqvist C. B., Borger M. A., Di Mario C., Dickstein K., Ducrocq G., Fernandez-Aviles F., Gershlick A. H., Giannuzzi P., Halvorsen S., Huber K., Juni P., Kastrati A., Knuuti J., Lenzen M. J., Mahaffey K. W., Valgimigli M., Van'T Hof A., Widimsky P., Zahger D., Bax J. J., Baumgartner H., Ceconi C., Dean V., Deaton C., Fagard R., Funck-Brentano C., Hasdai D., Hoes A., Kirchhof P., Kolh P., McDonagh T., Moulin C., Popescu B. A., Reiner Z., Sechtem U., Sirnes P. A., Tendera M., Torbicki A., Vahanian A., Windecker S., Astin F., Astrom-Olsson K., Budaj A., Clemmensen P., Collet J. -P., Fox K. A., Fuat A., Gustiene O., Hamm C. W., Kala P., Lancellotti P., Maggioni A. P., Merkely B., Neumann F. -J., Piepoli M. F., Van De Werf F., Verheugt F., Wallentin L., Steg, P, James, S, Atar, D, Badano, L, Lundqvist, C, Borger, M, Di Mario, C, Dickstein, K, Ducrocq, G, Fernandez-Aviles, F, Gershlick, A, Giannuzzi, P, Halvorsen, S, Huber, K, Juni, P, Kastrati, A, Knuuti, J, Lenzen, M, Mahaffey, K, Valgimigli, M, Van'T Hof, A, Widimsky, P, Zahger, D, Bax, J, Baumgartner, H, Ceconi, C, Dean, V, Deaton, C, Fagard, R, Funck-Brentano, C, Hasdai, D, Hoes, A, Kirchhof, P, Kolh, P, Mcdonagh, T, Moulin, C, Popescu, B, Reiner, Z, Sechtem, U, Sirnes, P, Tendera, M, Torbicki, A, Vahanian, A, Windecker, S, Astin, F, Astrom-Olsson, K, Budaj, A, Clemmensen, P, Collet, J, Fox, K, Fuat, A, Gustiene, O, Hamm, C, Kala, P, Lancellotti, P, Maggioni, A, Merkely, B, Neumann, F, Piepoli, M, Van De Werf, F, Verheugt, F, Wallentin, L, Steg P. G., James S. K., Atar D., Badano L., Lundqvist C. B., Borger M. A., Di Mario C., Dickstein K., Ducrocq G., Fernandez-Aviles F., Gershlick A. H., Giannuzzi P., Halvorsen S., Huber K., Juni P., Kastrati A., Knuuti J., Lenzen M. J., Mahaffey K. W., Valgimigli M., Van'T Hof A., Widimsky P., Zahger D., Bax J. J., Baumgartner H., Ceconi C., Dean V., Deaton C., Fagard R., Funck-Brentano C., Hasdai D., Hoes A., Kirchhof P., Kolh P., McDonagh T., Moulin C., Popescu B. A., Reiner Z., Sechtem U., Sirnes P. A., Tendera M., Torbicki A., Vahanian A., Windecker S., Astin F., Astrom-Olsson K., Budaj A., Clemmensen P., Collet J. -P., Fox K. A., Fuat A., Gustiene O., Hamm C. W., Kala P., Lancellotti P., Maggioni A. P., Merkely B., Neumann F. -J., Piepoli M. F., Van De Werf F., Verheugt F., and Wallentin L.

Published
2012

149. European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts)

Author

Graham, I., Atar, D., Borch-Johnsen, K., Boysen, G., Burell, G., Cifkova, R., Dallongeville, J., Backer, G. de, Ebrahim, S., Gjelsvik, B., Hermann-Lingen, C., Hoes, A.W., Humphries, S.E., Knapton, M., Perk, J., Priori, S.G., Pyorala, K., Reiner, Z., Ruilope, L., Sans-Menendez, S., Scholte op Reimer, W.J., Weissberg, P., Wood, D.J., Yarnell, J.W., Zamorano, J.L., Walma, E.P., Fitzgerald, T., Cooney, M.T., Dudina, A., Vahanian, A., Camm, J., Caterina, R. de, Dean, V., Dickstein, K., Funck-Brentano, C., Filippatos, G., Hellemans, I., Kristensen, S.D., McGregor, K., Sechtem, U., Silber, S., Tendera, M., Widimsky, P., Altiner, A., Bonora, E., Durrington, P.N., Fagard, R., Giampaoli, S., Hemingway, H., Hakansson, J., Kjeldsen, S.E., Larsen, L., Mancia, G., Manolis, A.J., Orth-Gomer, K., Pedersen, T., Rayner, M., Ryden, L., Sammut, M., Schneiderman, N., Stalenhoef, A.F.H., Tokgozoglu, L., Wiklund, O., and Zampelas, A.

Subjects
Health aging / healthy living [IGMD 5], Cardiovascular diseases [NCEBP 14], Vascular medicine and diabetes [UMCN 2.2]
Abstract

Contains fulltext : 52037.pdf (Publisher’s version ) (Closed access)

Published
2007

150. 2012 Focused Update of the ESC Guidelines for the Management of Atrial Fibrillation [Actualización detallada de las guías de la ESC para el manejo de la fibrilación auricular de 2012]

Author

Camm AJ, Lip GYH, De Caterina R, Savelieva I, Atar D, Hohnloser SH, Hindricks G, Kirchhof P, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck Brentano C, Hasdai D, Hoes A, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, Vardas P, Al Attar N, ALFIERI , OTTAVIO, Angelini A, Blomstrom Lundqvist C, Colonna P, De Sutter J, Ernst S, Goette A, Gorenek B, Hatala R, Heidbuchel H, Heldal M, Kristensen SD, Le Heuzey JY, Mavrakis H, Mont L, Filardi PP, Ponikowski P, Prendergast B, Rutten FH, Schotten U, Van Gelder IC, Verheugt FWA, Camm, Aj, Lip, Gyh, De Caterina, R, Savelieva, I, Atar, D, Hohnloser, Sh, Hindricks, G, Kirchhof, P, Bax, Jj, Baumgartner, H, Ceconi, C, Dean, V, Deaton, C, Fagard, R, Funck Brentano, C, Hasdai, D, Hoes, A, Knuuti, J, Kolh, P, Mcdonagh, T, Moulin, C, Popescu, Ba, Reiner, Z, Sechtem, U, Sirnes, Pa, Tendera, M, Torbicki, A, Vahanian, A, Windecker, S, Vardas, P, Al Attar, N, Alfieri, Ottavio, Angelini, A, Blomstrom Lundqvist, C, Colonna, P, De Sutter, J, Ernst, S, Goette, A, Gorenek, B, Hatala, R, Heidbuchel, H, Heldal, M, Kristensen, Sd, Le Heuzey, Jy, Mavrakis, H, Mont, L, Filardi, Pp, Ponikowski, P, Prendergast, B, Rutten, Fh, Schotten, U, Van Gelder, Ic, and Verheugt, Fwa

Published
2013

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