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101. Melanoma liver metastases with special imaging features on magnetic resonance imaging after microwave ablations: How to evaluate technical efficacy?

Author

Cao, Fei, Xie, Lin, Qi, Han, Ze, Song, Chen, Shuanggang, Shen, Lujun, Zhang, Xiaoshi, and Fan, Weijun

Subjects
Metastasis -- Care and treatment -- Patient outcomes, Magnetic resonance imaging -- Evaluation, Ablation (Surgery) -- Complications and side effects -- Patient outcomes, Liver cancer -- Care and treatment -- Patient outcomes, Health
Abstract

Byline: Fei. Cao, Lin. Xie, Han. Qi, Song. Ze, Shuanggang. Chen, Lujun. Shen, Xiaoshi. Zhang, Weijun. Fan Purpose: To evaluate the technical feasibility of microwave ablation (MWA) for melanoma liver [...]

Published
2019

102. Identification of prognosis-related cyclin-dependent kinases and potential response drugs in hepatocellular carcinoma.

Author

Chen, Shuanggang, Shen, Binyan, Wu, Ying, Shen, Lujun, Qi, Han, Cao, Fei, Huang, Tao, Tan, Hongtong, Zhang, Guoping, and Fan, Weijun

Subjects
CYCLIN-dependent kinases, TRANSCRIPTION factors, GENE expression, PROGESTERONE receptors, PROGRESSION-free survival, CHRONIC active hepatitis
Abstract

Context and Aims: Which cyclin-dependent kinases (CDKs) involved in the progress of hepatocellular carcinoma (HCC) need to be further clarified. To identify prognostic-relevant biomarkers in HCC through a systematic investigation of the prognostic value of CDKs. Methods and Material: We explored the relationship between CDKs expression and the prognosis of patients with HCC using multiple online databases. In addition, their biological functions and correlation with the immune system and drug response were investigated. Results: Among the 20 CDKs (CDK1 ~20) altered in HCC, the significantly high expression of CDK1 and CDK4 in patients with HCC was significantly associated with worse prognosis. Interestingly, CDK1 had significant co-occurrence with CDK4 and CDK1-related and CDK4-related signaling pathways are closely related to hepatitis virus–related HCC. We identified multiple transcription factors of CDK1 and CDK4; of those, only four (E2F1, PTTG1, RELA, and SP1) were significantly associated with the prognosis of HCC patients. Genetic alterations in CDKs were significantly correlated with disease-free and progression-free survival, which may be associated with aberrant expression of progesterone receptor. Moreover, we found a significantly positive correlation between CDK1 and CDK4 expression and tumor-infiltrating activated CD4+ T cell and exhausted T cell–related signature. Finally, we identified drugs with good potential prognostic value predicted by CDK1 and CDK4 levels. Conclusions: CDK1 and CDK4 may be potential prognostic biomarkers for HCC. Moreover, targeting four transcription factors (E2F1, PTTG1, RELA, and SP1) combined with immunotherapy may be a new therapeutic strategy for treating HCC patients with high CDK1 and CDK4 expression, especially hepatitis-related HCC. [ABSTRACT FROM AUTHOR]

Published
2023
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104. Inducible Regulatory T Cell Predicts Efficacy of PD‐1 Blockade Therapy in Melanoma (Adv. Therap. 4/2022)

Author

Shen, Lujun, primary, Wu, Ying, additional, Qi, Han, additional, Jiang, Yiquan, additional, Jin, Jietian, additional, Cao, Fei, additional, Chen, Shuanggang, additional, Yang, Yuanzhong, additional, Huang, Tao, additional, Song, Ze, additional, Chen, Qifeng, additional, Zhang, Yinqi, additional, Mo, Jinqing, additional, Li, Dandan, additional, Zhang, Xiaoshi, additional, and Fan, Weijun, additional

Published
2022
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108. Additional file 1 of Real-time automatic prediction of treatment response to transcatheter arterial chemoembolization in patients with hepatocellular carcinoma using deep learning based on digital subtraction angiography videos

Author

Zhang, Lu, Jiang, Yicheng, Jin, Zhe, Jiang, Wenting, Zhang, Bin, Wang, Changmiao, Wu, Lingeng, Chen, Luyan, Chen, Qiuying, Liu, Shuyi, You, Jingjing, Mo, Xiaokai, Liu, Jing, Xiong, Zhiyuan, Huang, Tao, Yang, Liyang, Wan, Xiang, Wen, Ge, Han, Xiao Guang, Fan, Weijun, and Zhang, Shuixing

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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120. Removing sulfur dioxide from smelting flue and increasing resource utilization of copper tailing through the liquid catalytic oxidation

Author

Fan Weijun, Ping Ning, Langlang Wang, Lei Tao, and Xueqian Wang

Subjects
020209 energy, General Chemical Engineering, Energy Engineering and Power Technology, chemistry.chemical_element, 02 engineering and technology, Copper, Flue-gas desulfurization, chemistry.chemical_compound, Fuel Technology, 020401 chemical engineering, chemistry, Catalytic oxidation, Chemical engineering, Smelting, 0202 electrical engineering, electronic engineering, information engineering, medicine, Slurry, Ferric, 0204 chemical engineering, Flue, Sulfur dioxide, medicine.drug
Abstract

Increasing the utilization of copper tailing and flue gas desulfurization is significant for copper smelters. Copper tailing, derived from the copper production, was applied to flue gas desulfurization and increasing utilization of copper tailing and smelting gas with low concentrations of SO2 by preparing slurries composed of copper tailing and water. The effects of different factors, including the inlet SO2 concentration, the ratio of solid to liquid, the absorption temperature, the O2 concentration, the gas flow rate, the initial copper tailing slurry pH, and the presence of a coexisting gas were investigated systematically. The resulting products and the mechanism driving the flue gas desulfurization were also studied. The results indicated that desulfurization efficiency was primarily influenced by the inlet SO2 concentration, the ratio of solid to liquid, the absorption temperature, and the gas flow rate. An appropriate amount of NO facilitated the desulfurization. The desulfurization efficiency was maintained at or above 80% for 60 h under optimal conditions. The total weight of the copper tailing was reduced by approximately 8%. Ferric sulfate and magnetite could be recycled through evaporation and magnetic separation. Liquid phase catalytic oxidation by metal ions, including ferric and manganese, played a vital role in the flue gas desulfurization.

Published
2019

121. Experimental Study on Effect of Electrode Location on Ion Current

Author

Xu Hanqing, Fan Weijun, and Zhang Rongchun

Subjects
Engineering (General). Civil engineering (General), TA1-2040
Abstract

In an attempt to use ion current method on a suction flame holder for combustion diagnosis, the position of the detection electrode that has the significant effect on ion current, should be investigated. The objective of this study was to experimentally investigate the ion current distribution in different combustion zones by changing the electrode length and streamwise location. An ion current acquisition system was built on basis of the principle of Langmuir probe, and experiments were conducted under different fuel-air ratios ranging from 0.008~0.022. The results suggest that the ion current distribution obeys the same regulation at different fuel-air ratios. With the electrode length increasing, the ion current increases first, then decreases, and finally presents a unimodal curve. As the electrode streamwise location increases, the ion current demonstrates a linear decrease rule. The maximum ion current is obtained in the case that the electrode length and streamwise location equals 60mm and 0.75. Since the larger ion current provides the wider range for setting the misfire threshold, the position where the maximum ion current occurs can be a better choice for arranging the electrode.

Published
2017
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124. Consensus of Minimally Invasive and Multidisciplinary Comprehensive Treatment for Hepatocellular Carcinoma – 2020 Guangzhou Recommendations

Author

Chen, Qi-Feng, primary, Li, Wang, additional, Yu, Simon Chun-ho, additional, Chou, Yi-Hong, additional, Rhim, Hyunchul, additional, Yang, Xiaoming, additional, Shen, Lujun, additional, Dong, Annan, additional, Huang, Tao, additional, Huang, Jinhua, additional, Zhang, Fujun, additional, Fan, Weijun, additional, Zhao, Ming, additional, Gu, Yangkui, additional, Huang, Zhimei, additional, Zuo, Mengxuan, additional, Zhai, Bo, additional, Xiao, Yueyong, additional, Kuang, Ming, additional, Li, Jiaping, additional, Han, Jianjun, additional, Song, Wei, additional, Ma, Jie, additional, and Wu, Peihong, additional

Published
2021
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127. Ge₀.₉₅Sn₀.₀₅ gate-all-around p-channel metal-oxide-semiconductor field-effect transistors with sub-3 nm nanowire width

Author

Kang, Yuye, Xu, Shengqiang, Han, Kaizhen, Kong, Eugene Y.-J., Song, Zhigang, Luo, Sheng, Kumar, Annie, Wang, Chengkuan, Fan, Weijun, Liang, Gengchiau, Gong, Xiao, and School of Electrical and Electronic Engineering

Subjects
Nanowire, GeSn, Electrical and electronic engineering [Engineering]
Abstract

We demonstrate Ge0.95Sn0.05 p-channel gate-all-around field-effect transistors (p-GAAFETs) with sub-3 nm nanowire width (WNW) on a GeSn-on-insulator (GeSnOI) substrate using a top-down fabrication process. Thanks to the excellent gate control by employing an aggressively scaled nanowire structure, Ge0.95Sn0.05 p-GAAFETs exhibit a small subthreshold swing (SS) of 66 mV/decade, a decent on-current/off-current (ION/IOFF) ratio of ∼1.2 × 106, and a high-field effective hole mobility (μeff) of ∼115 cm2/(V s). In addition, we also investigate quantum confinement effects in extremely scaled GeSn nanowires, including threshold voltage (VTH) shift and IOFF reduction with continuous scaling of WNW under 10 nm. The phenomena observed from experimental results are substantiated by the calculation of GeSn bandgap and TCAD simulation of electrical characteristics of devices with sub-10 nm WNW. This study suggests Ge-based nanowire p-FETs with extremely scaled dimension hold promise to deliver good performance to enable further scaling for future technology nodes. National Research Foundation (NRF) This work at NUS was supported by Singapore Ministry of Education (MOE) Tier 2 (MOE2018-T2-2-154) and MOE Tier 1 (R-263-000-D65-114). Prof. Fan Weijun acknowledges the support from the National Research Foundation Singapore (NRF-CRP19-2017-01).

Published
2021

131. Band structure of strained Ge 1− x Sn x alloy : a full-zone 30-band k · p model

Author

Song, Zhigang, Fan, Weijun, Tan, Chuan Seng, Wang, Qijie, Nam, Donguk, Zhang, Dao Hua, Sun, Greg, and School of Electrical and Electronic Engineering

Subjects
Ge, Materials [Engineering], GeSn Alloy
Abstract

We extend the previous 30-band k· p model effectively employed for relaxed Ge1−xSnx alloy to the case of strained Ge1−xSnx alloy. The strain-relevant parameters for the 30-band k· p model are obtained by using linear interpolation between the values of single crystal of Ge and Sn that are from literatures and optimizations. We specially investigate the dependence of bandgap at L-valley and -valley with different Sn composition under uniaxial and biaxial strain along [100], [110] and [111] directions. The good agreement between our theoretical predictions and experimental data validates the effectiveness of our model. Our 30-band k· p model and relevant input parameters successfully applied to relaxed and strained Ge1−xSnx alloy offers a powerful tool for the optimization of sophisticated devices made from such alloy. National Research Foundation (NRF) Accepted version

Published
2020

132. Effect of size on the electronic structure and optical properties of cubic CsPbBr₃ quantum dots

Author

Chen, Qiran, Song, Zhigang, Zhang, Daohua, Sun, Handong, Fan, Weijun, School of Electrical and Electronic Engineering, and School of Physical and Mathematical Sciences

Subjects
Electrical and electronic engineering [Engineering], Perovskite, CsPbBr₃
Abstract

The size effect on the electronic structure and optical properties of cubic CsPbBr3 perovskite quantum dots is investigated by using an 8-band k p model based on effective-mass envelope function theory with exciton binding energy consideration. Quantum dots with smaller size have larger bandgaps due to quantum confinement. The transition matrix element (TME) is also influenced by the size. The optical gain of such material is calculated by considering TME, Fermi factor, injected carrier density, quantum dot size, and dephasing rate. Higher density of injected carrier is needed for smaller quantum dot to get a positive optical gain. The peak of optical gain has a blue shift as the size of quantum dot decreases. When the carrier density increases for a quantum dot with certain size, a blue shift in emission peak position can be observed due to band filling effect. Smaller quantum dots have higher differential optical gain at carrier densities within certain range. Ministry of Education (MOE) This work was supported in part by the Singapore MOE AcRF Tier 1 RG87/17 and in part by the AStar under Grant 1720700038.

Published
2020

134. Expert consensus workshop report: Guidelines for thermal ablation of primary and metastatic lung tumors (2018 edition)

Author

Ye, Xin, Fan, Weijun, Wang, Hui, Wang, Junjie, Wang, Zhongmin, Gu, Shanzhi, Feng, Weijian, Zhuang, Yiping, Liu, Baodong, Li, Xiaoguang, Li, Yuliang, Li, Chengli, Xiao, Yueyong, Yang, Po, Yang, Xia, Yang, Wuwei, Chen, Junhui, Zhang, Rong, Lin, Zhengyu, Meng, Zhiqiang, Hu, Kaiwen, Liu, Chen, Peng, Zhongmin, Han, Yue, Jin, Yong, Lei, Guangyan, Zhai, Bo, and Huang, Guanghui

Subjects
Lung cancer -- Complications and side effects -- Care and treatment, Practice guidelines (Medicine) -- Evaluation, Ablation (Surgery) -- Methods, Cancer metastasis -- Care and treatment, Health
Abstract

Byline: Xin. Ye, Weijun. Fan, Hui. Wang, Junjie. Wang, Zhongmin. Wang, Shanzhi. Gu, Weijian. Feng, Yiping. Zhuang, Baodong. Liu, Xiaoguang. Li, Yuliang. Li, Chengli. Li, Yueyong. Xiao, Po. Yang, Xia. [...]

Published
2018

135. Computed tomography-guided percutaneous microwave ablation for treatment of peripheral ground-glass opacity-Lung adenocarcinoma: A pilot study

Author

Yang, Xia, Ye, Xin, Lin, Zhengyu, Jin, Yong, Zhang, Kaixian, Dong, Yuting, Yu, Guohua, Ren, Haipeng, Fan, Weijun, Chen, Jin, Lin, Qingfeng, Huang, Guanghui, Wei, Zhigang, Ni, Yang, Li, Wenhong, Han, Xiaoying, Meng, Min, Wang, Jiao, and Li, Yuliang

Subjects
Lung cancer -- Development and progression -- Care and treatment, Radiofrequency ablation -- Methods -- Patient outcomes, Cancer research, Health
Abstract

Byline: Xia. Yang, Xin. Ye, Zhengyu. Lin, Yong. Jin, Kaixian. Zhang, Yuting. Dong, Guohua. Yu, Haipeng. Ren, Weijun. Fan, Jin. Chen, Qingfeng. Lin, Guanghui. Huang, Zhigang. Wei, Yang. Ni, Wenhong. [...]

Published
2018

136. Value of ablation therapy in the treatment of lung metastases

Author

Qi, Han and Fan, Weijun

Subjects
Invited Review, Lung Neoplasms, renal cancer, Ablation therapy, colorectal cancer, lung metastases, Sarcoma, respiratory system, Disease-Free Survival, Kidney Neoplasms, respiratory tract diseases, Treatment Outcome, Catheter Ablation, bone and soft tissue sarcoma, Humans, Neoplasm Metastasis, Colorectal Neoplasms
Abstract

Tumor metastases are the basic biological characteristics of malignant tumors, and the lungs are the second most prominent metastatic organs in which these develop after the liver. Currently, with the rapid development of ablation technology, ablation therapy as a local treatment is playing an increasingly important role in the treatment of lung metastases. Whether alone or in combination with other treatments, ablation therapy has achieved good therapeutic effects for the treatment of partial lung metastases. This article briefly summarizes the results of current and previous ablation treatments for lung metastases, and focuses on the value of ablation therapy for different kinds of lung metastases.

Published
2017

140. Single-nodule hepatitis B virus-associated hepatocellular carcinoma smaller than 3 cm: two phenotypes defined by cluster analysis and their association with the outcome of ablation as the first-line therapy

Author

Chen, Shuanggang, primary, Wu, Ying, additional, Qi, Han, additional, Shen, Lujun, additional, Ma, Weimei, additional, Cao, Fei, additional, Diao, Yuhong, additional, Wang, Ting, additional, Ou, Shunling, additional, and Fan, Weijun, additional

Published
2021
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143. Intermediate stage hepatocellular carcinoma: Comparison of the value of inflammation-based scores in predicting progression-free survival of patients receiving transarterial chemoembolization

Author

Fan, Weijun, primary, Liu, Ying, additional, Shi, Menting, additional, Chen, Shuanggang, additional, Wan, Weiqi, additional, Shen, Lujun, additional, Shen, Binyan, additional, Qi, Han, additional, Cao, Fei, additional, Wu, Ying, additional, Huang, Tao, additional, Chen, Guanjian, additional, Mo, Jinqing, additional, Ye, Dongdong, additional, Zhang, Yinqi, additional, and Feng, Ziqing, additional

Published
2021
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146. Role of PRDM1 in Tumor Immunity and Drug Response: A Pan-Cancer Analysis

Author

Shen, Lujun, primary, Chen, Qifeng, additional, Yang, Changsheng, additional, Wu, Ying, additional, Yuan, Hui, additional, Chen, Shuanggang, additional, Ou, Shunling, additional, Jiang, Yiquan, additional, Huang, Tao, additional, Ke, Liangru, additional, Mo, Jinqing, additional, Feng, Ziqing, additional, Zhou, Penghui, additional, and Fan, Weijun, additional

Published
2020
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148. Polarity‐Switchable and Self‐Driven Photo‐Response Based on Vertically Stacked Type‐III GeSe/SnS2 Heterojunction.

Author

Wu, Liangwei, Gao, Wei, Sun, Yiming, Yang, MengMeng, Zheng, Zhaoqiang, Fan, Weijun, Shu, Kaixiang, Dan, Zhiying, Zhang, Nan, Huo, Nengjie, and Li, Jingbo

Subjects
FIELD-effect transistors, HETEROJUNCTIONS, N-type semiconductors, PHENOMENOLOGICAL theory (Physics)
Abstract

2D van der Waals (vdWs) heterostructure‐based multifunctional field effect transistor (FET) has brought about novel physical phenomena. Impressively, anti‐ambipolar characteristic is one of the basis logic functions being used in multi‐valued inverters, which is analogous to negative differential resistance (NDR)‐based transistor. Here, the tunable current‐transport and self‐driven optoelectrical properties of vertically stacked multilayer GeSe/SnS2 heterostructure are reported. In particular, it allows to be switched from n‐type‐dominant behavior to anti‐ambipolar operation regime (a large peak‐to‐valley ratio (PVR) of 1.5 × 103) as a result of different band‐bending under various bias. Under light‐doping engineering, the inverted V‐shaped peak is distinctly shifted because of the higher carrier recombination probability of p‐GeSe component. Besides, for photovoltaic performances, the device exhibits an ultralow dark current of ≈30 fA, a maximum responsivity of 130 mA W−1, and high Ion/Ioff ratio of ≈105 under 532 nm because of the large band offset and the efficient carrier separation process. Meanwhile, the polarization sensitivities can reach 1.9 at 405 nm and 2.6 at 635 nm. It is found that the polarity‐switchable behavior and self‐driven photodetection performance in GeSe/SnS2 vdWs FET can hopefully broaden and simplify the multifunctional integrated devices in the future. [ABSTRACT FROM AUTHOR]

Published
2022
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