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105. Central nervous system disorders after hematopoietic stem cell transplantation: a prospective study of the Infectious Diseases Working Party of EBMT

Author

Schmidt-Hieber, Martin, primary, Engelhard, Dan, additional, Ullmann, Andrew, additional, Ljungman, Per, additional, Maertens, Johan, additional, Martino, Rodrigo, additional, Rovira, Montserrat, additional, Shaw, Peter J., additional, Robin, Christine, additional, Faraci, Maura, additional, Byrne, Jenny, additional, Schäfer-Eckart, Kerstin, additional, Einsele, Hermann, additional, Faber, Edgar, additional, Rigacci, Luigi, additional, Saccardi, Riccardo, additional, Balaguer-Rosello, Aitana, additional, Isaksson, Cecilia, additional, Christopeit, Maximilian, additional, Tridello, Gloria, additional, Wang, Junfeng, additional, Knelange, Nina, additional, Mikulska, Malgorzata, additional, Cesaro, Simone, additional, and Styczynski, Jan, additional

Published
2019
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108. Cardiac and pulmonary late effects do not negatively influence performance status and non-relapse mortality of children surviving five yr after autologous hematopoietic cell transplantation: Report from the EBMT Paediatric Diseases and Late Effects Working Parties

Author

Uderzo, Cornelio, Pillon, Marta, Tridello, Gloria, Dini, Giorgio, Urban, Christian, Corti, Paola, Zintl, Felix, Fagioli, Franca, Messina, Chiara, Verdeguer, Amparo, Faraci, Maura, Fedeli, Sara, Tana, Francesco, Tichelli, André, Passweg, Jakob, and Rovelli, Attilio

Published
2009
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111. Additional file 1: of Early gut microbiota signature of aGvHD in children given allogeneic hematopoietic cell transplantation for hematological disorders

Author

Biagi, Elena, Zama, Daniele, Rampelli, Simone, Turroni, Silvia, Brigidi, Patrizia, Consolandi, Clarissa, Severgnini, Marco, Picotti, Eleonora, Gasperini, Pietro, Merli, Pietro, Decembrino, Nunzia, Zecca, Marco, Cesaro, Simone, Faraci, Maura, Prete, Arcangelo, Locatelli, Franco, Pession, Andrea, Candela, Marco, and Masetti, Riccardo

Subjects
surgical procedures, operative, integumentary system, immune system diseases, hemic and lymphatic diseases
Abstract

Figure S1. PCoA based on Bray-Curtis distances of genus-level relative abundance profiles of the samples sequenced in the present study using Illumina HiSeq and those from the study of Biagi et al. [7] sequenced by Roche 454 pyrosequencing. Figure S2. PCoA based on Bray-Curtis distances of genus-level relative abundance profiles of samples taken from patients aged 12 years, before, 12–28 days after, and > 30 days after HSCT. Figure S3. PCoA based on Bray-Curtis distances of genus-level relative abundance profiles of samples taken from patients hospitalized in the four centers before, 12–28 days after, and > 30 days after HSCT. Figure S4. Box and whiskers distribution of the relative abundance (%) of OTUs assigned to the genera Enterococcus, Citrobacter and Erwinia, in samples grouped as pre-HSCT, engraftment and post-HSCT, for the four enrollment centers. Figure S5. Box and whiskers distribution of the Simpson diversity index calculated for the genus-level microbiota profiles in samples taken before HSCT from subjects who did not develop aGvHD, who developed aGvHD (I-II grade) at a skin level, and who developed gastrointestinal aGvHD (II-IV grade). Figure S6. Box and whiskers distribution of the Bray-Curtis distances calculated using the genus-level gut microbiota profiles of samples taken before HSCT from subjects who did not develop aGvHD, who developed aGvHD (I-II grade) at a skin level, and who developed gastrointestinal aGvHD (II-IV grade). Figure S7. PCoA based on Bray-Curtis distances of genus-level relative abundance profiles of samples taken > 30 days after HSCT from patients who did not develop aGvHD, who developed aGvHD (I-II grade) at a skin level, and who developed gastrointestinal aGvHD (II-IV grade). (PDF 305 kb)

Published
2019
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112. Additional file 2: of Early gut microbiota signature of aGvHD in children given allogeneic hematopoietic cell transplantation for hematological disorders

Author

Biagi, Elena, Zama, Daniele, Rampelli, Simone, Turroni, Silvia, Brigidi, Patrizia, Consolandi, Clarissa, Severgnini, Marco, Picotti, Eleonora, Gasperini, Pietro, Merli, Pietro, Decembrino, Nunzia, Zecca, Marco, Cesaro, Simone, Faraci, Maura, Prete, Arcangelo, Locatelli, Franco, Pession, Andrea, Candela, Marco, and Masetti, Riccardo

Subjects
surgical procedures, operative, integumentary system, immune system diseases, hemic and lymphatic diseases
Abstract

Tables S1. Average relative abundances in pre-HSCT and engraftment samples, of the main discriminant genera between the two time points in subjects who did not develop aGvHD (non-aGvHD), who developed aGvHD (I-II grade) at a skin level (Skin aGvHD), and who developed gastrointestinal aGvHD (II-IV grade) (Gut aGvHD) (Wilcoxon test, P ≤ 0.05, in bold, in at least one group of subjects). P values between 0.05 and 0.1 are reported in italics, whereas P values > 0.1 are reported as “ns”, not significant. (PDF 257 kb)

Published
2019
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115. CD34+ selected peripheral blood Stem Cell Boost (SCB) for Poor Graft Function (PGF) or mixed chimerism in pediatric patients, after hematopoietic stem cell transplantation: Results of a retrospective multicenter study.

Author

Berger, Massimo, Faraci, Maura, Saglio, Francesco, Giardino, Stefano, Ernestina Vassallo, Elena, Prete, Arcangelo, and Fagioli, Franca

Subjects
*HEMATOPOIETIC stem cell transplantation, *CHILD patients, *STEM cells, *BLOOD cells, *CHIMERISM
Abstract

Background: PGF is historically associated with high morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Methods: In this study, we report our multicenter experience on stem cell boost (SCB) for PGF, or incomplete donor engraftment, in 16 pediatric patients. Donors were HLA‐matched siblings (n = 4), unrelated donors (n = 11), or haploidentical family members (n = 1). Ten patients had two‐lineage cytopenia, 5 had one‐lineage cytopenia, and 1 had poor immunological reconstitution together with a low percentage of donor cell engraftment. A median of 6.6x106 selected CD34+/Kg was infused after 194 days from allo‐HSCT (48‐607). Results: In 4 out of 5 patients, one‐lineage cytopenia was resolved, while among the 10 patients with two‐lineage cytopenia, 4 resolved both cytopenia, 5 resolved one‐lineage, and one did not respond. All patients reverted their mixed chimera to full donor chimera. OS was 56%, transplant‐related mortality (TRM) 32%, and RI 12%. The main causes of failure were related to infections with 4 out of 7 deaths caused by this. Conclusions: SCB may rescue over 50% of patients with PGF after allo‐HSCT. An earlier treatment may reduce the infectious complications and improve survival. [ABSTRACT FROM AUTHOR]

Published
2021
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116. Extracorporeal photochemotherapy for paediatric patients with graft-versus-host disease after haematopoietic stem cell transplantation

Author

MESSINA, CHIARA, LOCATELLI, FRANCO, LANINO, EDOARDO, UDERZO, CORNELIO, ZACCHELLO, GRAZIELLA, CESARO, SIMONE, PILLON, MARTA, PEROTTI, CESARE, DEL FANTE, CLAUDIA, FARACI, MAURA, RIVABELLA, LUCIA, CALORE, ELISABETTA, DE STEFANO, PIETRO, ZECCA, MARCO, GIORGIANI, GIOVANNA, BRUGIOLO, ALESSANDRA, BALDUZZI, ADRIANA, DINI, GIORGIO, ZANESCO, LUIGI, and DALLʼAMICO, ROBERTO

Published
2003

119. Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia After Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

Author

Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, Giuseppe, Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Milone, G., Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, Placanica, Paola, Girmenia, C, Bertaina, A, Piciocchi, A, Perruccio, K, Algarotti, A, Busca, A, Cattaneo, C, Raiola, Am, Guidi, S, Iori, Ap, Candoni, A, Irrera, G, Milone, G, Marcacci, G, Scimè, R, Musso, M, Cudillo, L, Sica, S, Castagna, L, Corradini, P, Marchesi, F, Pastore, D, Alessandrino, Ep, Annaloro, C, Ciceri, F, Santarone, S, Nassi, L, Farina, C, Viscoli, C, Rossolini, Gm, Bonifazi, F, Rambaldi, A, for the Gruppo Italiano Trapianto di Midollo Osseo, (GITMO), Associazione Microbiologi Clinici Italiani, (AMCLI), Girmenia, Corrado, Bertaina, Alice, Piciocchi, Alfonso, Perruccio, Katia, Algarotti, Alessandra, Busca, Alessandro, Cattaneo, Chiara, Raiola, Anna Maria, Guidi, Stefano, Iori, Anna Paola, Candoni, Anna, Irrera, Giuseppe, Milone, G., Marcacci, Giampaolo, Scimè, Rosanna, Musso, Maurizio, Cudillo, Laura, Sica, Simona, Castagna, Luca, Corradini, Paolo, Marchesi, Francesco, Pastore, Domenico, Alessandrino, Emilio Paolo, Annaloro, Claudio, Ciceri, Fabio, Santarone, Stella, Nassi, Luca, Farina, Claudio, Viscoli, Claudio, Rossolini, Gian Maria, Bonifazi, Francesca, Rambaldi, Alessandro, Capria, Saveria, Bertaina, A., Mastronuzzi, Angela, Pagliara, Daria, Bernaschi, Paola, Amico, Lucia, Carotti, Alessandra, Mencacci, Antonella, Busca, A., Bruno, Benedetto, Costa, Cristina, Passi, Angela, Ravizzola, Giuseppe, Angelucci, Emanuele, Marchese, Anna, Pecile, Patrizia, Candoni, A., Ventura, Giovanna, Fanin, Renato, Scarparo, Claudio, Barbaro, Angelo, Leotta, Salvatore, Marchese, Anna Elisa, Marcacci, G., Becchimanzi, Cristina, Donnarumma, Daniela, Tringali, Stefania, Baldi, Maria Teresa, Scalone, Renato, Cudillo, L., Picardi, Alessandra, Arcese, William, Fontana, Carla, Sica, S., Giammarco, Sabrina, Spanu, Teresa, Castagna, L., Crocchiolo, Roberto, Casari, Erminia, Mussetti, Alberto, Conte, Eutilia, Ensoli, Fabrizio, Miragliotta, Giuseppe, Marone, Piero, Arghittu, Milena, Greco, Raffaella, Forcina, Alessandra, Chichero, Paola, Santarone, S., Di Bartolomeo, Paolo, Fazii, Paolo, Kroumova, Vesselina, Decembrino, Nunzia, Zecca, Marco, Pisapia, Giovanni, Palazzo, Giulia, Lanino, Edoardo, Faraci, Maura, Castagnola, Elio, Bandettini, Roberto, Pastano, Rocco, Sammassimo, Simona, Passerini, Rita, Stefani, Piero Maria, Gherlinzoni, Filippo, Rigoli, Roberto, Prezioso, Lucia, Cambò, Benedetta, Calderaro, Adriana, Carella, Angelo Michele, Cascavilla, Nicola, Labonia, Maria Teresa, Celeghini, Ivana, Mordini, Nicola, Piana, Federica, Vacca, Adriana, Sanna, Marco, Podda, Giovanni, Corsetti, Maria Teresa, Rocchetti, Andrea, Cilloni, Daniela, De Gobbi, Marco, Bianco, Ornella, Fagioli, Franca, Carraro, Francesca, De Intinis, Gianfranco, Severino, Alessandro, Proia, Anna, Parisi, Gabriella, Vallisa, Daniele, Confalonieri, Massimo, Russo, Domenico, Malagola, Michele, Galieni, Piero, Falcioni, Sadia, Travaglini, Valeria, Raimondi, Roberto, Borghero, Carlo, Pavan, Giacomina, Prete, Arcangelo, Belotti, Tamara, Ambretti, Simone, Imola, Manuela, Mianulli, Anna Maria, Pedna, Maria Federica, Cesaro, Simone, Lo Cascio, Giuliana, Ferrari, Antonella, Piedimonte, Monica, Santino, Iolanda, Calandrelli, Monica, Olivieri, Attilio, Orecchioni, Francesca, Mirabile, Milena, Centurioni, Riccardo, Gironacci, Luciana, Caravelli, Daniela, Gallo, Susanna, De Filippi, Marco, Cupelli, Luca, Dentamaro, Teresa, Falco, Silvana, Eugenio, Ospedale S, Marotta, Serena, Risitano, Antonio, Lula, Dora, Musto, Pellegrino, Pietrantuono, Giuseppe, Traficante, Antonio, Cerchiara, Elisabetta, Tirindelli, Maria Cristina, Dicuonzo, Giordano, Chierichini, Anna, Anaclerico, Barbara, and Placanica, Paola

Subjects
0301 basic medicine, Male, Transplantation Conditioning, Drug Resistance, Bacteremia, 0302 clinical medicine, epidemiology, Gram negative bacteremia, multidrug resistance, stem cell transplant, survival, Risk Factors, Drug Resistance, Multiple, Bacterial, Epidemiology, Medicine, Age Factor, Prospective Studies, Prospective cohort study, Child, Transplantation, Homologou, education.field_of_study, Incidence (epidemiology), Incidence, Bacterial, Age Factors, Hematopoietic Stem Cell Transplantation, Middle Aged, Transplantation, Autologou, surgical procedures, operative, Infectious Diseases, Italy, Child, Preschool, Female, medicine.symptom, Multiple, Autologous, Human, Homologous, Microbiology (medical), Adult, medicine.medical_specialty, Adolescent, 030106 microbiology, Population, Transplantation, Autologous, 03 medical and health sciences, Young Adult, Internal medicine, Gram-Negative Bacteria, Gram-Negative Bacterial Infection, Escherichia coli, Humans, Transplantation, Homologous, Preschool, education, Aged, Gram-Negative Bacterial Infections, Infant, Transplantation, business.industry, Risk Factor, medicine.disease, Prospective Studie, Carriage, Otitis, business, Settore MED/15 - Malattie del Sangue, 030215 immunology
Abstract

Background Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. Methods We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant. Results The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45–3.13; P Conclusions Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto-HSCT and allo-HSCT. Previous infectious history and colonization monitoring represent major indicators of GNB. Clinical Trials registration NCT02088840.

Published
2017

120. Thalidomide as treatment of crohn‐like disease occurred after allogeneic hematopoietic stem cell transplantation in a pediatric patient.

Author

Giardino, Stefano, Bava, Cecilia, Arrigo, Serena, Pierri, Filomena, Gandullia, Paolo, Coccia, Cristina, and Faraci, Maura

Subjects
HEMATOPOIETIC stem cell transplantation, CHILD patients, THALIDOMIDE, THERAPEUTICS, INFLAMMATORY bowel diseases, DISEASE remission
Abstract

Background: Autoimmune diseases may occur after allogeneic hematopoietic stem cell transplantation (allo‐HSCT) and inflammatory bowel disease (IBD or Crohn disease) is rarely described. We describe a child who developed CD after allo‐HSCT, successfully treated with thalidomide. Case report: A child affected by mucopolysaccharidosis type I received two allogeneic HSCTs for rejection after the first one. After cutaneous and intestinal chronic GvHD and 6 months after HSCT, the patients developed a trilinear autoimmune cytopenia successfully treated with rituximab and sirolimus. Due to persisting intestinal symptoms, colonoscopies were performed and histological findings demonstrated a picture of CD. Based on this observation and according to the recommendations for the treatment of CD, thalidomide was started. A complete stable clinical response was obtained 8 weeks after start of thalidomide. Colonoscopy performed 4.8 years later demonstrated a complete endoscopic and histological remission of CD. Discussion: In this case, the diagnosis of CD after HSCT was based on histological findings. Indeed, repeated colonscopies were necessary for diagnosis, since both clinical and endoscopic features are often common to chronic GvHD and CD. Thalidomide was started at the dose of 1.7 mg/Kg/day, and it was well tolerated. Mild peripheral neurotoxicity occurred 5 years later but disappeared completely with the dose reduction. Currently, the patient is in complete remission from CD, despite the discontinuation of all the immunosuppressive therapies. Conclusions: Thalidomide could represent a therapeutic option to treat CD as autoimmune disease after allogeneic HSCT. [ABSTRACT FROM AUTHOR]

Published
2021
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121. Ruxolitinib in Pediatric Patients with Treatment-Naïveor Steroid-Refractory Acute Graft-Versus-Host Disease: Primary Findings from the Phase I/II REACH4 Study

Author

Locatelli, Franco, Kang, Hyoung Jin, Bruno, Bénédicte, Gandemer, Virginie, Rialland, Fanny, Faraci, Maura, Takahashi, Yoshiyuki, Koh, Katsuyoshi, Bittencourt, Henrique, Cleary, Grace, Rosko, Christine, Roussou, Pantelia, St. Pierre, Annie, Prahallad, Anirudh, and Díaz-de-Heredia, Cristina

Published
2022
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125. Late mortality and causes of death among 5-year survivors of childhood cancer diagnosed in the period 1960–1999 and registered in the Italian Off-Therapy Registry

Author

Bagnasco, Francesca, primary, Caruso, Silvia, additional, Andreano, Anita, additional, Valsecchi, Maria Grazia, additional, Jankovic, Momcilo, additional, Biondi, Andrea, additional, Miligi, Lucia, additional, Casella, Claudia, additional, Terenziani, Monica, additional, Massimino, Maura, additional, Sacerdote, Carlotta, additional, Morsellino, Vera, additional, Erminio, Giovanni, additional, Garaventa, Alberto, additional, Faraci, Maura, additional, Micalizzi, Concetta, additional, Garrè, Maria Luisa, additional, Pillon, Marta, additional, Basso, Giuseppe, additional, Biasin, Eleonora, additional, Fagioli, Franca, additional, Rondelli, Roberto, additional, Pession, Andrea, additional, Locatelli, Franco, additional, Santoro, Nicola, additional, Indolfi, Paolo, additional, Palumbo, Giovanna, additional, Russo, Giovanna, additional, Verzegnassi, Federico, additional, Favre, Claudio, additional, Zecca, Marco, additional, Mura, Rossella, additional, D'Angelo, Paolo, additional, Cano, Carmen, additional, Byrne, Julianne, additional, Haupt, Riccardo, additional, Pierani, Paolo, additional, Pession, Andreea, additional, Porta, Fulvio, additional, Consarino, Caterina, additional, Burnelli, Roberta, additional, Fedeli, Fausto, additional, Cellini, Monica, additional, Casale, Fiorina, additional, Menna, Giuseppe, additional, Bertolini, Patrizia, additional, Caniglia, Maurizio, additional, Cecinati, Valerio, additional, Casazza, Gabriella, additional, Foà, Roberto, additional, Clerico, Anna, additional, Ladogana, Saverio, additional, Galimberti, Daniela, additional, Rabusin, Marco, additional, Nespoli, Luigi, additional, and Cesaro, Simone, additional

Published
2019
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127. Sinusoidal Obstruction Syndrome/Veno-Occlusive Disease after Autologous or Allogeneic Hematopoietic Stem Cell Transplantation in Children: a retrospective study of the Italian Hematology-Oncology Association–Hematopoietic Stem Cell Transplantation Group

Author

Faraci, Maura, primary, Bertaina, Alice, additional, Luksch, Roberto, additional, Calore, Elisabetta, additional, Lanino, Edoardo, additional, Saglio, Francesco, additional, Prete, Arcangelo, additional, Menconi, Mariacristina, additional, De Simone, Giusy, additional, Tintori, Veronica, additional, Cesaro, Simone, additional, Santarone, Stella, additional, Orofino, Maria Grazia, additional, Locatelli, Franco, additional, and Zecca, Marco, additional

Published
2019
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128. Outcome of Transformed Fanconi Anaemia Patients after Hematopoietic Stem Cell Transplantation: Analysis on Behalf of European Group for Blood and Marrow Transplantation

Author

Giardino, Stefano, primary, Eikema, Dirk-Jan, additional, Peffault De Latour, Regis, additional, Bertrand, Yves, additional, Aljurf, Mahmoud, additional, Tbakhi, Abdelghani, additional, Holter, Wolfgang, additional, Bornhäsuer, Martin, additional, Rössig, Claudia, additional, Zecca, Marco, additional, Michel, Gerard, additional, Ganser, Arnold, additional, Afanasiev, Boris, additional, Al-Seraihy, Amal, additional, Bosman, Paul, additional, Miano, Maurizio, additional, Pierri, Filomena, additional, Faraci, Maura, additional, Lanino, Edoardo, additional, Risitano, Antonio M., additional, Kröger, Nicolaus, additional, and Dufour, Carlo, additional

Published
2018
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129. Clinical and morphological practices in the diagnosis of transplant-associated microangiopathy: a study on behalf of Transplant Complications Working Party of the EBMT

Author

Moiseev, Ivan S., primary, Tsvetkova, Tatyana, additional, Aljurf, Mahmoud, additional, Alnounou, Randa M, additional, Bogardt, Janet, additional, Chalandon, Yves, additional, Drokov, Mikhail Yu., additional, Dvirnyk, Valentina, additional, Faraci, Maura, additional, Friis, Lone Smidstrup, additional, Giglio, Fabio, additional, Greinix, Hildegard T., additional, Kornblit, Brian Thomas, additional, Koelper, Christiane, additional, Koenecke, Christian, additional, Lewandowski, Krzysztof, additional, Niederwieser, Dietger, additional, Passweg, Jakob R., additional, Peczynski, Christophe, additional, Penack, Olaf, additional, Peric, Zinaida, additional, Piekarska, Agnieszka, additional, Ronchi, Paola Erminia, additional, Rovo, Alicia, additional, Rzepecki, Piotr, additional, Scuderi, Francesca, additional, Sigrist, Daniel, additional, Siitonen, Sanna M., additional, Stoelzel, Friedrich, additional, Sulek, Kazimierz, additional, Tsakiris, Dimitrios A., additional, Wilkowojska, Urszula, additional, Duarte, Rafael F, additional, Ruutu, Tapani, additional, and Basak, Grzegorz W, additional

Published
2018
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130. Impact of in Vivo Lymphodepletion on Outcome in Children with Nonmalignant Disorders Receiving Peripheral Blood Stem Cell Transplantation

Author

Ottaviano, Giorgio, Achini-Gutzwiller, Federica, Kalwak, Krzysztof, Lanino, Edoardo, Faraci, Maura, Rao, Kanchan, Chiesa, Robert, Amrolia, Persis, Bonanomi, Sonia, Rovelli, Attilio, Veys, Paul, Lankester, Arjan, Balduzzi, Adriana, and Lucchini, Giovanna

Abstract

•Different serotherapy strategies did not provide a survival advantage in children affected by nonmalignant disorders receiving peripheral blood stem cell transplantation (PBSCT).•A higher rate of severe acute graft-versus-host disease occurred in patients receiving antithymocyte globulin.•Alemtuzumab negatively impacted T cell recovery in the first 3 months after PBSCT.

Published
2021
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131. Multifactorial Posterior Reversible Encephalopathy Syndrome in Children: Clinical, Laboratory, and Neuroimaging Findings.

Author

Morana, Giovanni, Bagnasco, Francesca, Leoni, Massimiliano, Pasquini, Luca, Gueli, Ilaria, Tortora, Domenico, Severino, Mariasavina, Giardino, Stefano, Pierri, Filomena, Micalizzi, Concetta, Verrina, Enrico, Ravelli, Angelo, Mancardi, Maria Margherita, Rossi, Andrea, and Faraci, Maura

Subjects
PATHOLOGICAL laboratories, CLINICAL pathology, GRAY matter (Nerve tissue), RETROSPECTIVE studies, MAGNETIC resonance imaging, MANN Whitney U Test, FISHER exact test, DISEASE incidence, CHI-squared test, DESCRIPTIVE statistics, POSTERIOR leukoencephalopathy syndrome, NEURORADIOLOGY, CHILDREN
Abstract

The aim of this study was to investigate the association of neuroimaging, clinical, and laboratory findings in children with different underlying diseases who developed posterior reversible encephalopathy syndrome (PRES). All consecutive pediatric patients referred to our institute between 2000 and 2017 were retrospectively evaluated for newly diagnosed PRES. Clinical data, medical history, and therapies administered at the time of PRES and laboratory findings were reviewed as the magnetic resonance imaging (MRI) obtained at PRES presentation and during follow-up. Statistics included Mann–Whitney U, Chi-square, and Fisher's exact tests. A total of 39 pediatric patients (25 males, median age = 8.8 years) with a confirmed diagnosis of PRES were included. The patients were divided into four groups based on the underlying disease: (1) patients with hemato-oncological diseases not transplanted ( n  = 15, 38.5%), (2) who underwent hematopoietic stem cell transplantation (HSCT; n  = 12, 30.8%), (3) affected by renal ( n  = 8, 20.5%), and (4) by autoimmune diseases ( n  = 4, 10.2%). Hemato-oncological patients and those undergoing HSCT presented a higher incidence of involvement of deep gray matter structures and hemorrhagic lesions when compared with patients with renal and autoimmune disorders ( p  = 0.036 and p  = 0.036, respectively). No differences emerged among different groups of patients regarding presenting PRES symptoms, arterial blood pressure, laboratory findings, and extent of MRI abnormalities and these parameters did not show association with outcome. In conclusion, in pediatric patients with different diseases who develop PRES, involvement of deep gray matter structures and hemorrhagic lesions are more common in hemato-oncological patients and those undergoing HSCT. Clinical and radiologic outcome is favorable independently of clinical data and extent of MRI abnormalities. [ABSTRACT FROM AUTHOR]

Published
2021
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134. Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita

Author

Fioredda, Francesca, primary, Iacobelli, Simona, additional, Korthof, Elisabeth T., additional, Knol, Cora, additional, van Biezen, Anja, additional, Bresters, Dorine, additional, Veys, Paul, additional, Yoshimi, Ayami, additional, Fagioli, Franca, additional, Mats, Brune, additional, Zecca, Marco, additional, Faraci, Maura, additional, Miano, Maurizio, additional, Arcuri, Luca, additional, Maschan, Michael, additional, O'Brien, Tracey, additional, Diaz, Miguel A., additional, Sevilla, Julian, additional, Smith, Owen, additional, Peffault de Latour, Regis, additional, de la Fuente, Josue, additional, Or, Reuven, additional, Van Lint, Maria T., additional, Tolar, Jakub, additional, Aljurf, Mahmoud, additional, Fisher, Alain, additional, Skorobogatova, Elena V., additional, Diaz de Heredia, Cristina, additional, Risitano, Antonio, additional, Dalle, Jean-Hugues, additional, Sedláček, Petr, additional, Ghavamzadeh, Ardeshir, additional, and Dufour, Carlo, additional

Published
2018
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136. RAG deficiency with ALPS features successfully treated with TCRαβ/CD19 cell depleted haploidentical stem cell transplant

Author

Westermann-Clark, Emma, primary, Grossi, Alice, additional, Fioredda, Francesca, additional, Giardino, Stefano, additional, Cappelli, Enrico, additional, Terranova, Paola, additional, Palmisani, Elena, additional, Farmer, Jocelyn R., additional, Foldvari, Zsofia, additional, Yamazaki, Yasuhiro, additional, Faraci, Maura, additional, Lanino, Edoardo, additional, Notarangelo, Luigi D., additional, Dufour, Carlo, additional, Ceccherini, Isabella, additional, Walter, Jolan E., additional, and Miano, Maurizio, additional

Published
2018
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137. CD70 Deficiency due to a Novel Mutation in a Patient with Severe Chronic EBV Infection Presenting As a Periodic Fever

Author

Caorsi, Roberta, primary, Rusmini, Marta, additional, Volpi, Stefano, additional, Chiesa, Sabrina, additional, Pastorino, Claudia, additional, Sementa, Angela Rita, additional, Uva, Paolo, additional, Grossi, Alice, additional, Lanino, Edoardo, additional, Faraci, Maura, additional, Minoia, Francesca, additional, Signa, Sara, additional, Picco, Paolo, additional, Martini, Alberto, additional, Ceccherini, Isabella, additional, and Gattorno, Marco, additional

Published
2018
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139. Monitoring of Busulphan Concentrations in Children Undergone Hematopoietic Stem Cell Transplantation: Unicentric Experience over 10 years

Author

Faraci, Maura, primary, Tinelli, Carmine, additional, Lanino, Edoardo, additional, Giardino, Stefano, additional, Leoni, Massimiliano, additional, Ferretti, Marta, additional, Castagnola, Elio, additional, Broglia, Monica, additional, De Silvestri, Annalisa, additional, Di Martino, Daniela, additional, and Bartoli, Antonella, additional

Published
2017
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140. Current use and potential role of procalcitonin in the diagnostic work up and follow up of febrile neutropenia in hematological patients

Author

Bruno, Benedetto, primary, Busca, Alessandro, additional, Vallero, Stefano, additional, Raviolo, Stefania, additional, Mordini, Nicola, additional, Nassi, Luca, additional, Cignetti, Alessandro, additional, Audisio, Ernesta, additional, Festuccia, Moreno, additional, Corsetti, Alessandra, additional, Depaoli, Lorella, additional, Faraci, Maura, additional, Micalizzi, Concetta, additional, Corcione, Silvia, additional, Berger, Massimo, additional, Saglio, Francesco, additional, Caropreso, Paola, additional, Mengozzi, Giulio, additional, Squadrone, Vincenzo, additional, De Rosa, Francesco Giuseppe, additional, and Giaccone, Luisa, additional

Published
2017
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142. Epidemiology of invasive fungal diseases in children with solid tumours undergoing autologous haematopoietic stem cell transplantation: a 10-year experience in a tertiary Italian centre

Author

Tatarelli, Paola, primary, Faraci, Maura, additional, Caviglia, Ilaria, additional, Bandettini, Roberto, additional, Cangemi, Giuliana, additional, Magnano, Gian Michele, additional, Garaventa, Alberto, additional, Viscoli, Claudio, additional, and Castagnola, Elio, additional

Published
2017
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145. Single-Lineage Bone Marrow Failure Driven By 2 Novel PI3KCD Mutations

Author

Miano, Maurizio, primary, Fioredda, Francesca, additional, Grossi, Alice, additional, Cappelli, Enrico, additional, Palmisani, Elena, additional, Faraci, Maura, additional, Lanza, Tiziana, additional, Terranova, Paola, additional, Calvillo, Michaela, additional, Micalizzi, Concetta, additional, Lanino, Edoardo, additional, Pierri, Filomena, additional, Giardino, Stefano, additional, Ceccherini, Isabella, additional, and Dufour, Carlo, additional

Published
2016
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146. Long-term outcome after allogeneic hematopoietic stem cell transplantation for Shwachman–Diamond syndrome: a retrospective analysis and a review of the literature by the Severe Aplastic Anemia Working Party of the European Society for Blood and Marrow Transplantation (SAAWP-EBMT)

Author

Cesaro, Simone, Pillon, Marta, Sauer, Martin, Smiers, Frans, Faraci, Maura, de Heredia, Cristina Diaz, Wynn, Robert, Greil, Johann, Locatelli, Franco, Veys, Paul, Uyttebroeck, Anne, Ljungman, Per, Chevalier, Patrice, Ansari, Marc, Badell, Isabel, Güngör, Tayfun, Salim, Rahuman, Tischer, Johanna, Tecchio, Cristina, Russell, Nigel, Chybicka, Alicja, Styczynski, Jan, Krivan, Gergely, Smith, Owen, Stein, Jerry, Afanasyev, Boris, Pochon, Cécile, Menconi, Maria Cristina, Bosman, Paul, Mauro, Margherita, Tridello, Gloria, de Latour, Regis Peffault, and Dufour, Carlo

Abstract

Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative procedure in patients with Shwachman–Diamond syndrome (SDS) with bone marrow abnormalities. The results of 74 patients with SDS (6 acute myeloid leukemia, 7 myelodysplastic syndrome, and 61 bone marrow failure) treated with HSCT between 1988 and 2016 are reported. The donor source was: 24% sibling, 8% parent, and 68% unrelated donor. The stem cell source was: 70% bone marrow, 19% peripheral blood stem cells, and 11% cord blood. The conditioning regimen was myeloablative in 54% and reduced intensity in 46%. Neutrophil engraftment was achieved in 84% of patients after a median time of 17.5 days. Graft failure occurred in 15% of HSCTs. Grades I–IV acute and chronic GVHD were observed in 55% and 20% of patients, respectively. After a median follow-up of 7.3 years (95% CI 4.8–10.2), 28 patients died for progression/relapse (7) or toxicity (21). The 5-year overall survival and nonrelapse mortality were 63.3% (95% CI 50.8–73.4) and 19.8% (95% CI 10.8–30.8), respectively. In conclusion, this is the largest series so far reported and confirms that HSCT is a suitable option for patients with SDS. Further efforts are needed to lower transplant-related toxicity and reduce graft failure.

Published
2020
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147. Gonadal Function after Busulfan Compared with Treosulfan in Children and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplant.

Author

Faraci, Maura, Diesch, Tamara, Labopin, Myriam, Dalissier, Arnaud, Lankester, Arian, Gennery, Andrew, Sundin, Mikael, Uckan-Cetinkaya, Duygu, Bierings, Marc, Peters, Anke M.J., Garwer, Martina, Schulz, Ansgar, Michel, Gerard, Giorgiani, Giovanna, Gruhn, Bernd, Locatelli, Franco, Giardino, Stefano, Uyttebroeck, Anne, Rialland, Fanny, and Itäla-Remes, Maija

Subjects
*HEMATOPOIETIC stem cells, *STEM cell transplantation, *BUSULFAN, *MENARCHE, *TEENAGERS, *CHILDREN
Abstract

• This study compared gonadal function after Bu or Treo in pre- and postpubertal children. • Spontaneous puberty was reached more frequently after Treo (P =.02). • Spontaneous menarche was reached more frequently after Treo (P <.001). • Luteinizing hormone (LH) levels were lower in patients treated with Treo. Gonadal impairment is an important late effect with a significant impact on quality of life of transplanted patients. The aim of this study was to compare gonadal function after busulfan (Bu) or treosulfan (Treo) conditioning regimens in pre- and postpubertal children. This retrospective, multicenter study included children transplanted in pediatric European Society for Blood and Marrow Transplantation (EBMT) centers between 1992 and 2012 who did not receive gonadotoxic chemoradiotherapy before the transplant. We evaluated 137 patients transplanted in 25 pediatric EBMT centers. Median age at transplant was 11.04 years (range, 5 to 18); 89 patients were boys and 48 girls. Eighty-nine patients were prepubertal at transplant and 48 postpubertal. One hundred eighteen children received Bu and 19 Treo. A higher proportion of girls treated with Treo in the prepubertal stage reached spontaneous puberty compared with those treated with Bu (P =.02). Spontaneous menarche was more frequent after Treo than after Bu (P <.001). Postpubertal boys and girls treated with Treo had significantly lower luteinizing hormone levels (P =.03 and P =.04, respectively) compared with the Bu group. Frequency of gonadal damage associated with Treo was significantly lower than that observed after Bu. These results need to be confirmed in a larger population. [ABSTRACT FROM AUTHOR]

Published
2019
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150. Candida infections in paediatrics: Results from a prospective single‐centre study in a tertiary care children's hospital

Author

Mesini, Alessio, primary, Bandettini, Roberto, additional, Caviglia, Ilaria, additional, Fioredda, Francesca, additional, Amoroso, Loredana, additional, Faraci, Maura, additional, Mattioli, Girolamo, additional, Piaggio, Giorgio, additional, Risso, Francesco M., additional, Moscatelli, Andrea, additional, Loy, Anna, additional, and Castagnola, Elio, additional

Published
2016
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