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734 results on '"Felson, D.T."'

106. The association between adult hip morphology and hip osteoarthritis: a systematic review

Author

van Buuren, M.M., primary, Arden, N.K., additional, Bierma-Zeinstra, S.M., additional, Bramer, W.M., additional, Casartelli, N.C., additional, Felson, D.T., additional, Jones, G., additional, Lane, N.E., additional, Lindner, C., additional, Maffiuletti, N.A., additional, van Meurs, J.B., additional, Nelson, A.E., additional, Nevitt, M.C., additional, Valenzuela, P.L., additional, Verhaar, J.A., additional, Weinans, H.H., additional, and Agricola, R., additional

Published
2020
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109. The relation of physical activity with fatigue in persons with symptomatic knee osteoarthritis and its potential mediation by physical function or depressive symptoms: the most study

Author

Fawole, H.O., primary, Felson, D.T., additional, Jafarzadeh, S.R., additional, Dell'Isola, A., additional, Steultjens, M.P., additional, Nevitt, M.C., additional, Lewis, C.E., additional, Frey-Law, L.A., additional, Riskowski, J.L., additional, and Chastin, S.F., additional

Published
2020
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112. Relation of synovitis to knee pain using contrast-enhanced MRIs

Author

Baker, K., Grainger, A., Niu, J., Clancy, M., Guermazi, A., Crema, M., Hughes, L., Buckwalter, J., Wooley, A., Nevitt, M., and Felson, D.T.

Subjects
Synovitis -- Research, Knee pain -- Risk factors, Knee pain -- Demographic aspects, Knee pain -- Development and progression, Knee pain -- Research, Magnetic resonance imaging -- Usage, Magnetic resonance imaging -- Research, Health
Published
2010

113. High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study

Author

Nevitt, M.C., Zhang, Y., Javaid, M.K., Neogi, T., Curtis, J.R., Niu, J., McCulloch, C.E., Segal, N.A., and Felson, D.T.

Subjects
Osteoarthritis -- Risk factors, Osteoarthritis -- Demographic aspects, Osteoarthritis -- Research, Knee -- Physiological aspects, Knee -- Research, Diagnosis, Radioscopic -- Analysis, Bones -- Density, Bones -- Research, Health
Published
2010

115. Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis

Author

Roemer, F.W., Guermazi, A., Javaid, M.K., Lynch, J.A., Niu, J., Zhang, Y., Felson, D.T., Lewis, C.E., Torner, J., and Nevitt, M.C.

Subjects
Osteoarthritis -- Development and progression, Osteoarthritis -- Risk factors, Osteoarthritis -- Research, Knee -- Diseases, Knee -- Research, Bone marrow -- Diseases, Bone marrow -- Research, Health
Published
2009

117. Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury

Author

Watt, F.E., Corp, N., Kingsbury, S.R., Frobell, R., Englund, M., Felson, D.T., Levesque, M., Majumdar, S., Wilson, C., Beard, D.J., Lohmander, L.S., Kraus, V.B., Roemer, F., Conaghan, P.G., Mason, D.J., Adams, J., Blank, M., Batt, M., Biggs, P., Busse-Morris, M., Button, K., Calder, J., Cook, J., Edwards, C., Fisheleva, E., Hamilton, D.F., Harrison, H., Holt, C., Jones, M., Jones, R, Kluzek, S., Knight, T., Nuki, G., Parekh, S., Peat, G., Pothet, C., Rainer, T., Robinson, N., Sawle, L., Vincent, T., Williams, A., Wise, E., Zhang, W., and Bierma-Zeinstra, S.

Subjects
Osteoarthritis, Injury, Outcome, Clinical trial, Knee, Considerations
Abstract

Objective: There are few guidelines for clinical trials of interventions for prevention of post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including patients was convened to generate points to consider for the design and conduct of interventional studies following acute knee injury.\ud \ud Design: An evidence review on acute knee injury interventional studies to prevent PTOA was presented to the group, alongside overviews of challenges in this area, including potential targets, biomarkers and imaging. Working groups considered pre-identified key areas: eligibility criteria and outcomes, biomarkers, injury definition and intervention timing including multi-modality interventions. Consensus agreement within the group on points to consider was generated and is reported here after iterative review by all contributors.\ud \ud Results: The evidence review identified 37 studies. Study duration and outcomes varied widely and 70% examined surgical interventions. Considerations were grouped into three areas: justification of inclusion criteria including the classification of injury and participant age (as people over 35 may have pre-existing OA); careful consideration in the selection and timing of outcomes or biomarkers; definition of the intervention(s)/comparator(s) and the appropriate time-window for intervention (considerations may be particular to intervention type). Areas for further research included demonstrating the utility of patient-reported outcomes, biomarkers and imaging outcomes from ancillary/cohort studies in this area, and development of surrogate clinical trial endpoints that shorten the duration of clinical trials and are acceptable to regulatory agencies.\ud \ud Conclusions: These considerations represent the first international consensus on the conduct of interventional studies following acute knee joint trauma.

Published
2019

121. The effect of alendronate on progression of spinal osteophytes and disc-space narrowing

Author

Neogi, T., Nevitt, M.C., Ensrud, K.E., Bauer, D., and Felson, D.T.

Subjects
Alendronate -- Dosage and administration, Alendronate -- Research, Osteoarthritis -- Development and progression, Osteoarthritis -- Care and treatment, Osteoarthritis -- Research, Bone spurs -- Physiological aspects, Bone spurs -- Research, Health
Published
2008

123. Body fat and skeletal muscle mass in relation to physical disability in very old men and women of the Framingham Heart Study

Author

Visser, M., Harris, T.B., Langlois, J., Hannan, M.T., Roubenoff, R., Felson, D.T., Wilson, P.W.F., and Kiel, D.P.

Subjects
Body composition -- Physiological aspects, Body weight -- Physiological aspects, Adipose tissues -- Physiological aspects, Aged -- Physiological aspects, Health, Seniors
Abstract

Background. Low muscle mass has been assumed to be associated with disability, but no studies confirming this association have been published. High body weight and high body mass index, both rough indicators of body fatness, have been shown to increase the risk for disability; however, the specific role of body fatness has not been studied. Methods. The relations of skeletal muscle mass and percent body fat with self-reported physical disability were studied in 753 men and women aged 72 to 95 years. Cross-sectional data from biennial examination 22 (1992-1993) of the Framingham Heart Study were used. Body composition was assessed by dual-energy x-ray absorptiometry. Disability was scored as any versus none on a 9-item questionnaire. Results. Total body and lower extremity muscle mass were not associated with disability in either men or women. However, a strong positive association between percent body fat and disability was observed. The odds ratio for disability in those in the highest tertile of body fatness was 2.69 (95% confidence interval 1.45-5.00) for women and 3.08 (1.22-7.81) for men compared to those in the lowest tertile. The increased risk could not be explained by age, education, physical activity, smoking, alcohol use, estrogen use (women only), muscle mass, and health status. Analyses restricting disability to mobility items gave similar results. Conclusions. In contrast to current assumptions, low skeletal muscle mass was not associated with self-reported physical disability. Persons with a high percent body fat had high levels of disability. Because it cannot be ruled out that persons with low skeletal muscle mass dropped out earlier in the study, prospective studies are needed to further assess the relationship between body composition and physical disability.

Published
1998

124. Cigarette smoking and the risk for cartilage loss and knee pain in men with knee osteoarthritis

Author

Amin, S., Niu, J., Guermazi, A., Grigoryan, M., Hunter, D.J., Clancy, M., LaValley, M.P., Genant, H.K., and Felson, D.T.

Subjects
Osteoarthritis -- Research, Osteoarthritis -- Physiological aspects, Osteoarthritis -- Risk factors, Smoking -- Research, Smoking -- Health aspects, Knee pain -- Risk factors, Knee pain -- Research, Men -- Health aspects, Men -- Research, Health
Published
2007

125. Patient preferences for treatment of rheumatoid arthritis

Author

Fraenkel, L., Bogardus, S.T., Concato, J., Felson, D.T., and Wittink, D.R.

Subjects
Rheumatoid arthritis -- Drug therapy, Patients -- Surveys, Patients -- Analysis, Methotrexate -- Beliefs, opinions and attitudes, Leflunomide -- Beliefs, opinions and attitudes, Gold -- Beliefs, opinions and attitudes, Etanercept -- Beliefs, opinions and attitudes, Health
Published
2004

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