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104 results on '"Flt3 gene"'

102. Murky waters for MRD detection in AML: flightyFLT3/ITDs

Author

D. Gary Gilliland

Subjects
ABL, Immunology, Mutant, breakpoint cluster region, Context (language use), Cell Biology, Hematology, Disease pathogenesis, Biology, medicine.disease, Biochemistry, Leukemia, hemic and lymphatic diseases, Cancer research, medicine, Flt3 gene, Gene
Abstract

A guiding principle in the application of MRD monitoring in leukemia has been that the mutant genes present at diagnosis and causally implicated in disease pathogenesis will be harbingers of molecular relapse. This principle has been thoroughly validated, for example, in the context of BCR/ABL in

Published
2002
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103. Point mutations in the FLT3 gene in AML

Author

James D. Griffin

Subjects
Protein Conformation, education, Immunology, Mutation, Missense, Biology, Biochemistry, Domain (software engineering), Structure-Activity Relationship, fluids and secretions, Proto-Oncogene Proteins, hemic and lymphatic diseases, Humans, Point Mutation, Phosphorylation, Codon, Kinase, Point mutation, Receptor Protein-Tyrosine Kinases, Myeloid leukemia, hemic and immune systems, Cell Biology, Hematology, Neoplasm Proteins, Enzyme Activation, Amino Acid Substitution, fms-Like Tyrosine Kinase 3, Leukemia, Myeloid, Acute Disease, embryonic structures, Cancer research, Asparagine, Flt3 gene, Protein Processing, Post-Translational, Tyrosine kinase
Abstract

Approximately 20% of acute myeloid leukemia (AML) patients have been found to have constitutive activation of the FLT3-receptor tyrosine kinase due to internal tandem duplications of the juxtamembrane domain (FLT3-ITD). Yamamoto and colleagues (page [2434][1]) now report that Asp835 in the kinase

Published
2001
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104. Cancer Treatment’s New Direction.

Author

Winslow, Ron

Subjects
*CANCER treatment, *ACUTE myeloid leukemia treatment, *GENETIC testing, *STEM cell transplantation, *TREATMENT effectiveness
Published
2016

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