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There are observable decreases in muscle strength as a result of ageing that occur from the age of 40, which are thought to occur as a result of changes within the neuromuscular system. Strength-training in older adults is a suitable intervention that may counteract the age-related loss in force production. The neuromuscular adaptations (i.e., cortical, spinal and muscular) to strength-training in older adults are largely equivocal and a systematic review with meta-analysis will serve to clarify the present circumstances regarding the benefits of strength-training in older adults. 20 studies entered the meta-analysis and were analysed using a random-effects model. A best evidence synthesis that included 36 studies was performed for variables that had insufficient data for meta-analysis. One study entered both. There was strong evidence that strength-training increases maximal force production, rate of force development and muscle activation in older adults. There was limited evidence for strength-training to improve voluntary-activation, the volitional-wave and spinal excitability, but strong evidence for increased muscle mass. The findings suggest that strength-training performed between 2 and 12 weeks increases strength, rate of force development and muscle activation, which likely improves motoneurone excitability by increased motor unit recruitment and improved discharge rates. • This review reports a lack of evidence for studies examining the sites of adaptation to strength-training in older adults. • Strength-training has a limited effect on spinal excitability, voluntary activation, neural drive; but increases muscle mass. • Strength-training is an effective intervention that counteracts the age-related decline in maximal force production. [ABSTRACT FROM AUTHOR]

In this paper we develop and analyze the metrics associated with a force production task involving a stationary target with the help of advanced VR and Force Dimension Omega 6 haptic device. We study the effects of force magnitude and direction on the various metrics namely path length, movement smoothness, velocity and acceleration patterns, reaction time and overall error in achieving the target. Data was collected from 47 participants who were residents. Results show a positive correlation between the maximum force applied and the deflection error, velocity while reducing the path length and increasing smoothness with a force of higher magnitude showing the stabilizing characteristics of higher magnitude forces. This approach paves a way to assess and model procedural skills decay. [ABSTRACT FROM AUTHOR]

We investigated the ability of two persons to produce force-stabilizing synergies in accurate multi-finger force production tasks under visual feedback on the total force only. The subjects produced a time profile of total force (the sum of two hand forces in one-person tasks and the sum of two subject forces in two-person tasks) consisting of a ramp-up, steady-state, and ramp-down segments; the steady-state segment was interrupted in the middle by a quick force pulse. Analyses of the structure of inter-trial finger force variance, motor equivalence, anticipatory synergy adjustments (ASAs), and the unintentional drift of the sharing pattern were performed. The two-person performance was characterized by a dramatically higher amount of inter-trial variance that did not affect total force, higher finger force deviations that did not affect total force (motor equivalent deviations), shorter ASAs, and larger drift of the sharing pattern. The rate of sharing pattern drift correlated with the initial disparity between the forces produced by the two persons (or two hands). The drift accelerated following the quick force pulse. Our observations show that sensory information on the task-specific performance variable is sufficient for the organization of performance-stabilizing synergies. They suggest, however, that two actors are less likely to follow a single optimization criterion as compared to a single performer. The presence of ASAs in the two-person condition might reflect fidgeting by one or both of the subjects. We discuss the characteristics of the drift in the sharing pattern as reflections of different characteristic times of motion within the subspaces that affect and do not affect salient performance variables. [ABSTRACT FROM AUTHOR]

Control of intracellular transport is poorly understood, and functional ramifications of tubulin isoform differences between cell types are mostly unexplored. Motors' force production and detachment kinetics are critical for their group function, but how microtubule (MT) details affect these properties - if at all - is unknown. We investigated these questions using both a vesicular transport human kinesin, kinesin-1, and also a mitotic kinesin likely optimized for group function, kinesin-5, moving along either bovine brain or MCF7(breast cancer) MTs. We found that kinesin-1 functioned similarly on the two sets of MTs - in particular, its mean force production was approximately the same, though due to its previously reported decreased processivity, the mean duration of kinesin-1 force production was slightly decreased on MCF7 MTs. In contrast, kinesin-5's function changed dramatically on MCF7 MTs: its average detachment force was reduced and its force-velocity curve was different. In spite of the reduced detachment force, the force-velocity alteration surprisingly improved high-load group function for kinesin-5 on the cancer-cell MTs, potentially contributing to functions such as spindle-mediated chromosome separation. Significant differences were previously reported for C-terminal tubulin tails in MCF7 versus bovine brain tubulin. Consistent with this difference being functionally important, elimination of the tails made transport along the two sets of MTs similar. [ABSTRACT FROM AUTHOR]

Background: In skeletal muscle, intracellular Ca2+ is an important regulator of contraction as well as gene expression and metabolic processes. Because of the difficulties to obtain intact human muscle fibers, human myotubes have been extensively employed for studies of Ca2+-dependent processes in human adult muscle. Despite this, it is unknown whether the Ca2+-handling properties of myotubes adequately represent those of adult muscle fibers. Methods: To enable a comparison of the Ca2+-handling properties of human muscle fibers and myotubes, we developed a model of dissected intact single muscle fibers obtained from human intercostal muscle biopsies. The intracellular Ca2+-handling of human muscle fibers was compared with that of myotubes generated by the differentiation of primary human myoblasts obtained from vastus lateralis muscle biopsies. Results: The intact single muscle fibers all demonstrated strictly regulated cytosolic free [Ca2+] ([Ca2+]i) transients and force production upon electrical stimulation. In contrast, despite a more mature Ca2+-handling in myotubes than in myoblasts, myotubes lacked fundamental aspects of adult Ca2+-handling and did not contract. These functional differences were explained by discrepancies in the quantity and localization of Ca2+-handling proteins, as well as ultrastructural differences between muscle fibers and myotubes. Conclusions: Intact single muscle fibers that display strictly regulated [Ca2+]i transients and force production upon electrical stimulation can be obtained from human intercostal muscle biopsies. In contrast, human myotubes lack important aspects of adult Ca2+-handling and are thus an inappropriate model for human adult muscle when studying Ca2+-dependent processes, such as gene expression and metabolic processes. [ABSTRACT FROM AUTHOR]

The article focuses on a study conducted to determine the benefits of resistance training modalities involving whole-body vibration (WBV). It discusses the comparative effect of dynamic and static squats during WBV on the increased quadricep force produced due to dynamic extension of isokinetic knee and flexion exercise. The methods involved were prestrength and poststrength testing of individuals ranging from 18-25 years.

Nemaline myopathy, the most common congenital myopathy, is characterized by mutations in genes encoding myofilament proteins such as skeletal α-actin. These mutations are thought to ultimately lead to skeletal muscle weakness. Interestingly, some of the mutations appear to be more potent in males than in females. The underlying mechanisms remain obscure but may be related to sex-specific differences in the myofilament function of both limb and respiratory muscles. To verify this, in the present study, we used skeletal muscles (tibialis anterior and diaphragm) from a transgenic mouse model harbouring the His40Tyr amino acid substitution in skeletal α-actin. In this animal model, 60% of males die by 13 weeks of age (the underlying causes of death are obscure but probably due to respiratory insufficiency) whereas females have a normal lifespan. By recording and analysing the mechanics of membrane-permeabilized myofibres, we only observed sex-related differences in the tibialis anterior muscles. Indeed, the concomitant deficits in maximal steady-state isometric force and stiffness of myofibres were less exacerbated in transgenic females than in males, potentially explaining the lower potency in limb muscles. However, the absence of sex-difference in the diaphragm muscles was rather unexpected and suggests that myofilament dysfunction does not solely underlie the sexually dimorphic phenotypes. [ABSTRACT FROM AUTHOR]

Encoding muscular force output during voluntary contractions is widely perceived to result, at least in part, from modulations in neuronal activity within the sensorimotor cortex. However the underlying electrophysiological phenomena associated with increased force output remains unclear. This study directly assessed sensorimotor cortex activity using electroencephalography (EEG) in humans performing isometric knee-extensions at a range of discrete torque levels. Fifteen healthy males (age 24 (s = 5) years) completed one familiarization and one experimental trial. Participants performed a cyclic series of 60 isometric knee-extension contractions with the right leg, including 15 contractions of a 5-s duration at each of four discrete torque levels: 15%, 30%, 45% and 60% of maximal voluntary torque (MVT). Isometric knee-extension torque, quadriceps electromyography and EEG were recorded at rest and throughout all the contractions. EEG (0.5-50 Hz) was collected using a 32-channel active-electrode cap. A voxel-based low-resolution brain electromagnetic tomography (LORETA) analysis calculated cortical activation within the sensorimotor cortex (one of 27 MNI coordinates) for the entire 0.5-50-Hz range (cortical current density (CCD)), as well as for each constituent frequency band in this range (delta, theta, alpha, beta and gamma). Gamma band (30-50 Hz) cortical activity increased with contraction torque (analysis of variance [ANOVA], P = 0.03). Conversely, activity within the other frequency bands was not modulated by torque (P ≥ 0.09), nor was overall CCD (P = 0.11). Peripheral neuromuscular activation (quadriceps electromyography (EMG) amplitude) demonstrated distinct increases between each torque level (P < 0.01). In conclusion, sensorimotor cortical activity within the gamma band demonstrated an overall increase with contraction torque, whereas both CCD and each of the other constituent frequency bands were not modulated by increments in torque magnitude during isometric knee-extension contractions up to 60%MVT. [ABSTRACT FROM AUTHOR]

AMP-activated protein kinase (AMPK) is a sensor of cellular energy status that plays a central role in skeletal muscle metabolism. We used skeletalmuscle-specific AMPKα1α2 double-knockout (mdKO) mice to provide direct genetic evidence of the physiological importance of AMPK in regulatingmuscle exercise capacity, mitochondrial function, and contraction-stimulated glucose uptake. Exercise performance was significantly reduced in the mdKO mice, with a reduction in maximal force production and fatigue resistance. An increase in the proportion of myofibers with centralized nuclei was noted, as well as an elevated expression of interleukin 6 (IL-6) mRNA, possibly consistent with mild skeletal muscle injury. Notably, we found thatAMPKα1 and AMPKα2 isoforms are dispensable for contraction-induced skeletal muscle glucose transport, except for male soleus muscle. However, the lack of skeletal muscle AMPK diminished maximal ADP-stimulated mitochondrial respiration, showing an impairment at complex I. This effect was not accompanied by changes in mitochondrial number, indicating that AMPK regulates muscle metabolic adaptation through the regulation of musclemitochondrial oxidative capacity and mitochondrial substrate utilization but not baseline mitochondrial muscle content. Together, these results demonstrate that skeletal muscle AMPK has an unexpected role in the regulation of mitochondrial oxidative phosphorylation that contributes to the energy demands of the exercising muscle. [ABSTRACT FROM AUTHOR]

The purpose of this study was to examine whether split step (small hop before step) would be more beneficial than no-split condition in simulated tennis response situation. In addition, it was studied if movement time of the response is related to separately measured force production capabilities and reflex sensitivity of the players. Nine skilled male tennis players participated in this study. Subjects stood on a force plate and reacted to a light signal and moved to appointed direction as fast as possible. With split step the participants were 13.1% faster (P <0.05) than without split step from the start to the distal end of the so called close range movement continuum (2.70 m). This was mainly explained by 43.6% faster time (P <0.05) from the signal to the onset of force production. Greater vertical forces were observed with split step: 15.7% greater F(z) mean force (P <0.05), 60.0% greater F(z) peak force (P<0.01). In split step both mean (r= − 0.813, P <0.01) and peak (r=−0.765, P <0.05) vertical forces (Fz) correlated negatively with the time from the onset of the force production to the photocell. With split step higher EMGs were observed in muscles responsible for ankle joint movement indicating that different strategies were used. Due to the split step the players were able to start the movement faster which mostly explains the advantages over the no-split step condition. Split step condition may also benefit from stretch shortening type of muscle action. [ABSTRACT FROM AUTHOR]

Purpose: Evaluate the effects of 6 weeks of specific-joint isometric strength training on serve velocity (SV), serve accuracy (SA), and force-time curve variables., Methods: Sixteen young competition tennis players were divided into an intervention (n = 10) or control group (n = 6). SV, SA, maximal voluntary isometric contraction, peak rate of force development, rate of force development, and impulse (IMP) at different time frames while performing a shoulder internal rotation (SHIR) or flexion were tested at weeks 0, 3, and 6., Results: The intervention group showed significant increases in SV from pretest to posttest (7.0%, effect size [ES] = 0.87) and no variations in SA. Moreover, the intervention group showed significant increases from pretest to posttest in shoulder-flexion rate of force development at 150 (30.4%, ES = 2.44), 200 (36.5%, ES = 1.26), and 250 ms (43.7%, ES = 1.67) and in SHIR IMP at 150 (35.7%, ES = 1.18), 200 (33.4%, ES = 1.19), and 250 ms (35.6%, ES = 1.08). Furthermore, significant increases were found in shoulder-flexion rate of force development from intertest to posttest at 150 ms (24.5%, ES = 1.07) and in SHIR IMP at 150 (13.5%, ES = 0.90), 200 (19.1%, ES = 0.98), and 250 ms (27.2%, ES = 1.16). SHIR IMP changes from pretest to intertest were found at 150 ms (25.6%, ES = 1.04). The control group did not show changes in any of the tested variables., Conclusions: Six weeks of upper-limb specific-joint isometric strength training alongside habitual technical-tactical workouts results in significant increases in SV without SA detriment in young tennis players.

This study examined the effects of constant or variable external resistance training on neuromuscular adaptations in the lower limbs of older men. 37 subjects (age 65 ± 4 year) were quasi-randomly assigned to the constant or variable training group, or a non-training control group. Training consisted of a 20-week medium-intensity, high volume resistance training program. Maximum bilateral concentric and isometric force production of the leg extensors as well as repetitions-to-failure test were performed pre-, mid- and post-training. Vastus lateralis muscle cross-sectional area was assessed by ultrasound and lean leg mass was assessed by dual-energy x-ray absorptiometry. Both training groups significantly increased force production of the leg extensors (variable: 26 kg, 95 % CI = 12-39, P < 0.01; constant: 31 kg, 95 % CI = 19-43, P < 0.01) and VL cross-sectional area (variable: 1.5 cm2 , 95 % CI = 0.03-3.1, P = 0.046; constant: 3 cm2 , 95 % CI = 1.2-4.8, P = 0.002). However, only the variable training group significantly improved repetitions to failure performance (704 kg, 95 % CI = 45-1 364, P = 0.035). Only the variable resistance training group improved fatigue-resistance properties, which may be an important adaptation to maintain exercise and functional capacity in older individuals. [ABSTRACT FROM AUTHOR]

The article presents information on a study which analyzes the effects of Tabata interval-training program using an aquatic underwater treadmill on different performance variables. It included 25 subjects who participated in a 8-week Tabata interval-training program, and measured body fat percentage, force production, flexibility, and anaerobic power. The methods and results of the study are also discussed.

BACKGROUND: There are few standardised assessments of unilateral muscular endurance and little data examining the validity and reproducibility of isokinetic unilateral muscular endurance performance measures. OBJECTIVE: To examine the validity and reproducibility of an isokinetic assessment of lower limb unilateral muscular endurance performance.METHODS: Thirty individuals (15 endurance trained and 15 non-endurance trained) repeated a time to exhaustion (TTE) based endurance protocol on separate days. Procedures were conducted on an isokinetic dynamometer and involved leg extension through 135° of the dominant leg. The TTE protocol required participants to perform unilateral isokinetic leg extensions at 60% of individual maximal voluntary contraction (MVC) until the specified intensity and frequency could not be maintained. RESULTS: The endurance trained individuals reached significantly greater TTE than their non-endurance trained counterparts (P< 0.001). Systemic bias was small (< 5%) and measures were similar between trials. Test-retest reproducibility statistics were as follows; CV: 6.9%; LOA -170.1 to 139.5; RLOA: -0.320 ×/÷ 0.257. Relative reproducibility statistics were tight between trials (significant correlation P< 0.001).CONCLUSIONS: Data demonstrate the validity and tight test-retest reproducibility of the aforementioned assessment of unilateral muscular endurance performance. [ABSTRACT FROM AUTHOR]

BACKGROUND: There are alterations in strength in relation to menstrual cycle phase but little data attributing these responses to female sex hormone levels using a pseudo-menstrual cycle group as control. OBJECTIVE: Examining the effects of menstrual cycle phase on the development of peak torque across a range of isokinetic speeds. METHOD: 17 well trained females, 11 formed the non-oral contraceptive group (n-OC) (age 20.7 ± 1.4 yrs, mass 59.2 ± 6.9 kg, height 166.8 ± 7.1 cm) and 6 the oral contraceptive control group (OC) (age 20.3 ± 0.5 yrs, mass 60.5 ± 4.2 kg, height 164.8 ± 4.8 cm). Concentric strength of the knee flexors and extensors (60-240°/s) was assessed, corresponding to menstruation (MEN), mid-follicular (mFOL), mid-luteal (mLUT) and pre-menstrual (pMEN). RESULTS: For n-OC significant decreases in peak torque production of the extensors at 120°/s (P=0.0207) (MEN) and of the flexors at 60°/s (P=0.0116) (MEN) and 120°/s (P=0.0282) (MEN) were observed compared to pMEN. No significant differences were observed across any menstrual cycle phase and peak torque for the OC group (p> 0.05). Significant positive correlations were observed (mLUT) between peak torque and oestrogen at 60°/s (P=0.040) and 120°/s (P=0.031). CONCLUSIONS: There are significant fluctuations in peak torque of the knee extensors in response to phases of the menstrual cycle associated with variances in the female sex hormones. The findings have implications for the planning of strength training in female athletes. [ABSTRACT FROM AUTHOR]

Introduction: The dystrophic features in hindlimb skeletal muscles of female mdx mice are unclear. Methods: We analyzed force-generating capacity and force decline after lengthening contraction-induced damage (fragility). Results: Young (6-month-old) female mdx mice displayed reduced force-generating capacity (−18%) and higher fragility (23% force decline) compared with female age-matched wild-type mice. These 2 dystrophic features were less accentuated in young female than in young male mdx mice (−32% and 42% force drop). With advancing age, force-generating capacity decreased and fragility increased in old (20 month) female mdx mice (−21% and 57% force decline), but they were unchanged in old male mdx mice. Moreover, estradiol treatment had no effect in old female mdx mice. Conclusions: Female gender-related factors mitigate dystrophic features in young but not old mdx mice. Further studies are warranted to identify the beneficial gender-related factor in dystrophic muscle. Muscle Nerve, 2013 [ABSTRACT FROM AUTHOR]

Bilateral force deficit refers to the phenomenon that maximal generated force during simultaneous bilateral muscle contractions is lower than the sum of forces generated unilaterally. Based on the notion that neural inhibition is the main source for bilateral force deficit and existing differences in neural inhibiting interhemispheric organization of proximal and distal muscles, we expected differences in bilateral deficit in proximal and distal joints. The aim of the current behavioral experiment was to compare bilateral force deficit in proximal compared to distal upper extremity joints. Ten young adults performed single-joint maximal voluntary contractions in isometric flexions of the shoulder and index finger unilaterally and bilaterally. The results showed a significant absolute bilateral force deficit for both proximal (140.01±86.99N) and distal muscles (4.64±4.86N). More importantly, relative bilateral force deficit for shoulder flexion was significantly larger than for index finger flexion, −20.51±7.8% and −5.07±3.84% respectively. The hypothesis of a more pronounced bilateral force deficit for proximal compared to distal muscles was confirmed in our results. Thus, our findings, in combination with the neuroanatomical differences for proximal and distal muscles, make it worthwhile to further explore the hypothesis that the commissural fibers provide differences in interhemispheric inhibitory interactions during bimanual actions for proximal and distal muscles. [ABSTRACT FROM AUTHOR]

This study examined the effects of elevated buffer capacity [~32 mM HCO] through administration of sodium bicarbonate (NaHCO) on maximally stimulated isolated mouse soleus (SOL) and extensor digitorum longus (EDL) muscles undergoing cyclical length changes at 37 °C. The elevated buffering capacity was of an equivalent level to that achieved in humans with acute oral supplementation. We evaluated the acute effects of elevated [HCO] on (1) maximal acute power output (PO) and (2) time to fatigue to 60 % of maximum control PO (T), the level of decline in muscle PO observed in humans undertaking similar exercise, using the work loop technique. Acute PO was on average 7.0 ± 4.8 % greater for NaHCO-treated EDL muscles ( P < 0.001; ES = 2.0) and 3.6 ± 1.8 % greater for NaHCO-treated SOL muscles ( P < 0.001; ES = 2.3) compared to CON. Increases in PO were likely due to greater force production throughout shortening. The acute effects of NaHCO on EDL were significantly greater ( P < 0.001; ES = 0.9) than on SOL. Treatment of EDL ( P = 0.22; ES = 0.6) and SOL ( P = 0.19; ES = 0.9) with NaHCO did not alter the pattern of fatigue. Although significant differences were not observed in whole group data, the fatigability of muscle performance was variable, suggesting that there might be inter-individual differences in response to NaHCO supplementation. These results present the best indication to date that NaHCO has direct peripheral effects on mammalian skeletal muscle resulting in increased acute power output. [ABSTRACT FROM AUTHOR]

Background Heavy prenatal alcohol exposure can result in diverse and extensive damage to the central nervous system, including the cerebellum, basal ganglia, and cerebral cortex. Given that these brain regions are involved in the generation and maintenance of motor force, we predicted that prenatal alcohol exposure would adversely affect this parameter of motor control. We previously reported that children with gestational alcohol exposure experience significant deficits in regulating isometric (i.e., constant) force. The purpose of this study was to determine whether these children exhibit similar deficits when producing isotonic (i.e., graded) force. Methods Children with heavy prenatal alcohol exposure and typically developing children completed a series of isotonic force contractions by exerting force on a load cell to match a criterion target force displayed on a computer monitor. Two levels of target force (5 or 20% of maximum voluntary force) were investigated in combination with varying levels of visual feedback. Results Compared with control children, children with heavy prenatal alcohol exposure generated isotonic force signals that were less accurate, more variable, and less complex in the time domain. Specifically, interactions were found between group and visual feedback for response accuracy and signal complexity, suggesting that these children have greater difficulty altering their motor output when visual feedback is low. Conclusions These data suggest that prenatal alcohol exposure produces deficits in regulating isotonic force, which presumably result from alcohol-related damage to developing brain regions involved in motor control. These children will most likely experience difficulty performing basic motor skills and daily functional skills that require coordination of finely graded force. Therapeutic strategies designed to increase feedback and, consequently, facilitate visual-motor integration could improve isotonic force production in these children. [ABSTRACT FROM AUTHOR]

Background: Energy drinks have become the most used caffeine-containing beverages in the sport setting. The aim of this study was to determine the effects of two doses of a caffeine-containing energy drink on muscle performance during upper- and lower-body power-load tests. Methods: In a randomized order, twelve active participants ingested 1 and 3 mg of caffeine per kg of body weight using a commercially available energy drink (Fure®, ProEnergetics) or the same drink without caffeine (placebo; 0 mg/kg). After sixty minutes, resting metabolic rate, heart rate and blood pressure were determined. Then, half-squat and bench-press power production with loads from 10 to 100% of 1 repetition maximum was determined using a rotator encoder. Results: In comparison to the placebo, the ingestion of the caffeinated drink increased mean arterial pressure (82 ± 7 < 88 ± 8 ≈ 90 ± 6 mmHg for 0 mg/kg, 1 mg/kg, 3 mg/kg of caffeine, respectively; P < 0.05) and heart rate (57 ± 7 < 59 ± 8 < 62 ± 8 beats/min, respectively; P < 0.05) at rest in a dose response manner, though it did not affect resting metabolic rate. While the ingestion of 1 mg/kg of caffeine did not affect maximal power during the power-load tests with respect to the placebo, 3 mg/kg increased maximal power in the half-squat (2554 ± 167 ≈ 2549 ± 161 < 2726 ± 167 W, respectively; P < 0.05) and bench-press actions (349 ± 34 ≈ 358 ± 35 < 375 ± 33 W, respectively; P < 0.05). Conclusions: A caffeine dose of at least 3 mg/kg in the form of an energy drink is necessary to significantly improve half-squat and bench-press maximal muscle power. [ABSTRACT FROM AUTHOR]

Background: Deficits in strength, power and balance represent important intrinsic risk factors for falls in seniors. Objective: The purpose of this study was to investigate the relationship between variables of lower extremity muscle strength/power and balance, assessed under various task conditions. Methods: Twenty-four healthy and physically active older adults (mean age: 70 ± 5 years) were tested for their isometric strength (i.e. maximal isometric force of the leg extensors) and muscle power (i.e. countermovement jump height and power) as well as for their steady-state (i.e. unperturbed standing, 10-meter walk), proactive (i.e. Timed Up & Go test, Functional Reach Test) and reactive (i.e. perturbed standing) balance. Balance tests were conducted under single (i.e. standing or walking alone) and dual task conditions (i.e. standing or walking plus cognitive and motor interference task). Results: Significant positive correlations were found between measures of isometric strength and muscle power of the lower extremities (r values ranged between 0.608 and 0.720, p < 0.01). Hardly any significant associations were found between variables of strength, power and balance (i.e. no significant association in 20 out of 21 cases). Additionally, no significant correlations were found between measures of steady-state, proactive and reactive balance or balance tests performed under single and dual task conditions (all p > 0.05). Conclusion: The predominately nonsignificant correlations between different types of balance imply that balance performance is task specific in healthy and physically active seniors. Further, strength, power and balance as well as balance under single and dual task conditions seem to be independent of each other and may have to be tested and trained complementarily. [ABSTRACT FROM AUTHOR]

This study investigated the effects of moderate dehydration (~2.5 % body weight) on muscle strength and endurance using percutaneous electrical stimulation to quantify central and peripheral fatigue, and isolate the combined effects of exercise-heat stress and dehydration, vs. the effect of dehydration alone. Force production and voluntary activation were calculated in 10 males during 1 brief and 15 repeated maximal voluntary isometric contractions performed prior to (control) walking in the heat (35°C), immediately following exercise, and the next morning (dehydration). The protocol was also performed in a euhydrated state. During the brief contractions, force production and voluntary activation were maintained in all trials. In contrast, force production decreased throughout the repeated contractions, regardless of hydration status ( P < 0.001). The decline in force was greater immediately following exercise-heat stress dehydration compared with control and euhydration ( P < 0.001). When dehydration was isolated from acute post-exercise dehydration, force production was maintained similarly to control and euhydration. Despite the progressive decline in force production and the increased fatigability observed during the repeated contractions, voluntary activation remained elevated throughout each muscle function test. Therefore, moderate dehydration, isolated from acute exercise-heat stress, does not appear to influence strength during a single contraction or enhance fatigability. [ABSTRACT FROM AUTHOR]

Abstract: Although the effects of attention on movement execution are well documented behaviorally, much less research has been done on the neurophysiological changes that underlie attentional focus effects. This study presents two experiments exploring effects of attention during an isometric plantar-flexion task using surface electromyography (sEMG). Participants'' attention was directed either externally (towards the force plate they were pushing against) or internally (towards their own leg, specifically the agonist muscle). Experiment 1 tested the effects of attention on accuracy and efficiency of force produced at three target forces (30, 60, and 100% of the maximum voluntary contraction; MVC). An internal focus of attention reduced the accuracy of force being produced and increased cocontraction of the antagonist muscle. Error on a given trial was positively correlated with the magnitude of cocontraction on that trial. Experiment 2 tested the effects of attention on muscular fatigue at 30, 60 and 100%MVC. An internal focus of attention led to less efficient intermuscular coordination, especially early in the contraction. These results suggest that an internal focus of attention disrupts efficient motor control in force production resulting in increased cocontraction, which potentially explains other neuromechanical findings (e.g. reduced functional variability with an internal focus). [Copyright &y& Elsevier]

Background: Deficits in static and particularly dynamic postural control and force production have frequently been associated with an increased risk of falling in older adults. Objective: The objectives of this study were to investigate the effects of salsa dancing on measures of static/dynamic postural control and leg extensor power in seniors. Methods: Twenty-eight healthy older adults were randomly assigned to an intervention group (INT, n = 14, age 71.6 ± 5.3 years) to conduct an 8-week progressive salsa dancing programme or a control group (CON, n = 14, age 68.9 ± 4.7 years). Static postural control was measured during one-legged stance on a balance platform and dynamic postural control was obtained while walking on an instrumented walkway. Leg extensor power was assessed during a countermovement jump on a force plate. Results: Programme compliance was excellent with participants of the INT group completing 92.5% of the dancing sessions. A tendency towards an improvement in the selected measures of static postural control was observed in the INT group as compared to the CON group. Significant group × test interactions were found for stride velocity, length and time. Post hoc analyses revealed significant increases in stride velocity and length, and concomitant decreases in stride time. However, salsa dancing did not have significant effects on various measures of gait variability and leg extensor power. Conclusion: Salsa proved to be a safe and feasible exercise programme for older adults accompanied with a high adherence rate. Age-related deficits in measures of static and particularly dynamic postural control can be mitigated by salsa dancing in older adults. High physical activity and fitness/mobility levels of our participants could be responsible for the nonsignificant findings in gait variability and leg extensor power. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Heat shock proteins play a key regulatory role in cellular defense. To investigate the role of the inducible 70-kDa heat shock protein (HSP70) in skeletal muscle atrophy and subsequent recovery, soleus (SOL) and extensor digitorum longus (EDL) muscles from overexpressing HSP70 transgenic mice were immobilized for 7 days and subsequently released from immobilization and evaluated after 7 days. Histological analysis showed that there was a decrease in cross-sectional area of type II myofiber from EDL and types I and II myofiber from SOL muscles at 7-day immobilization in both wild-type and HSP70 mice. At 7-day recovery, EDL and SOL myofibers from HSP70 mice, but not from wild-type mice, recovered their size. Muscle tetanic contraction decreased only in SOL muscles from wild-type mice at both 7-day immobilization and 7-day recovery; however, it was unaltered in the respective groups from HSP70 mice. Although no effect in a fatigue protocol was observed among groups, we noticed a better contractile performance of EDL muscles from overexpressing HSP70 groups as compared to their matched wild-type groups. The number of NCAM positive-satellite cells reduced after immobilization and recovery in both EDL and SOL muscles from wild-type mice, but it was unchanged in the muscles from HSP70 mice. These results suggest that HSP70 improves structural and functional recovery of skeletal muscle after disuse atrophy, and this effect might be associated with preservation of satellite cell amount. [ABSTRACT FROM AUTHOR]

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Abstract: Interhemispheric communication consists of a complex balance of facilitation and inhibition that is modulated in a task-dependent manner. However, it remains unclear how individual differences in interhemispheric interactions relate to motor performance. To assess interhemispheric inhibition, we utilized the ipsilateral silent period technique (iSP; evoked by suprathreshold transcranial magnetic stimulation), which elicits inhibition of volitional motor activity. Participants performed three force production tasks: (1) unimanual (right hand) constant force, (2) bimanual constant force, (bimanual simultaneous) and (3) bimanual with right hand constant force and left hand sine wave tracking (bimanual independent). We found that individuals with greater IHI capacity demonstrated reduced mirror EMG activity in the left hand during unimanual right hand contraction. However, these same individuals demonstrated the poorest performance during the bimanual independent force production task. We suggest that a high capacity for IHI from one motor cortex to another can effectively prevent “motor overflow” during unimanual tasks, but it can also limit interhemispheric cooperation during independently controlled bimanual tasks. [Copyright &y& Elsevier]

The authors discuss a study which has identified that the measurement of postural control and muscle strength in prepubertal children has no statistically significant associations. They state that maximal isometric torque and rate of force development have been measured in biomechanic tests. The authors note that the risk of injury is high for children who do not have fully developed neuromuscular systems.

Abstract: Forward models, generated from the efference copies of motor commands, are thought to monitor the accuracy of ongoing movement. By comparing predicted with actual afferent information, forward models also aid in the differentiation of self-produced movements from externally generated ones. Many have proposed that a consequence of this comparison is attenuation of the predicted component of incoming sensory signals. Previous work from our laboratory has shown that following the removal of an external visual reference, discrete sequential forces exceed target values. Forces produced at the fingertip were perceived as weaker, which lead to a systematic, compensatory over-production of the magnitudes required. The relatively new repetitive TMS protocol of continuous theta-burst stimulation (cTBS) has been shown to reliably depress cortical excitability for a period following stimulation. If sensory attenuation mechanisms were responsible for the overproduction of forces found in our previous results, we hypothesized that reducing cortical excitability of M1 through application of cTBS would induce discrepancy between the efference copy generated and motor output produced. As a result, we expected the overproduction of forces following visual feedback removal would be reduced after receiving cTBS. Participants produced series of pinch grip forces in time to a metronome and to visually specified force magnitudes. Visual feedback of force output was extinguished 10s into experimental trials and participants performed continued responses for the remaining 10s. Results confirmed our hypothesis. Mean peak force and constant error were greater and more positive in the absence of visual feedback regardless of stimulation condition; however, the magnitude of increase was significantly reduced following cTBS compared with baseline and sham conditions. Variability was not differentially affected by stimulation condition, increasing only with removal of visual feedback contingent upon the larger forces produced in these trials. Our findings provide further evidence to support the idea that TBS may differentially affect motor output and efference copy generation. [Copyright &y& Elsevier]

Muscle weakness following constant load exercise under heat stress has been associated with hyperthermia-induced central fatigue. However, evidence of central fatigue influencing intense self-paced exercise in the heat is lacking. The purpose of this investigation was to evaluate force production capacity and central nervous system drive in skeletal muscle pre- and post-cycle ergometer exercise in hot and cool conditions. Nine trained male cyclists performed a 20-s maximal voluntary isometric contraction (MVC) prior to (control) and following a 40-km time trial in hot (35°C) and cool (20°C) conditions. MVC force production and voluntary activation of the knee extensors was evaluated via percutaneous tetanic stimulation. In the cool condition, rectal temperature increased to 39.0°C and reached 39.8°C in the heat (P < 0.01). Following exercise in the hot and cool conditions, peak force declined by ~90 and ~99 N, respectively, compared with control (P < 0.01). Mean force decreased by 15% (hot) and 14% (cool) (P < 0.01 vs. control). Voluntary activation during the post-exercise MVC declined to 93.7% (hot) and 93.9% (cool) (P < 0.05 vs. control). The post-exercise decline in voluntary activation represented ~20% of the decrease in mean force production in both conditions. Therefore, the additional increase in rectal temperature did not exacerbate the loss of force production following self-paced exercise in the heat. The impairment in force production indicates that the fatigue exhibited by the quadriceps is mainly of peripheral origin and a consequence of the prolonged contractile activity associated with exercise. [ABSTRACT FROM AUTHOR]

The article presents a study that examined the relationship in adolescents between isometric and dynamic muscle strength, and variables of static and dynamic postural control. Variables of isometric and dynamic muscle strength were found to have positive correlations, while measures of static and dynamic postural control had no significant associations.

Research on the focus of attention has begun exploring the physiological changes that underlie the difference between internal and external foci of attention. However, previous electromyography studies have used dynamic tasks, making it difficult to interpret electrophysiological data. The authors analyzed how the focus of attention affects a subject's ability to perform an isometric force production task (focus was directed either at the force platform or the muscles responsible for force production). Subjects received practice without attentional focus instructions and then completed blocks of trials with an external and internal attentional focus separately. An external focus led to significantly less error overall and reduced surface electromyography activity with lower median power frequencies in the antagonist muscle, but attentional focus had no effects on the agonist muscle. Thus, an external focus of attention led to more efficient motor unit recruitment patterns (reduced cocontraction) and improved performance. Posttest surveys revealed subjects were aware of their improved performance with an external focus. [ABSTRACT FROM AUTHOR]

Abstract: Previous research suggests that removal of visual feedback of force output in a sequential force production task results in a continuous escalation of the force magnitudes produced. Central predictive mechanisms involving reafference result in self-generated forces being perceived as weaker, thus leading to a systematic over-production of force. While this effect has been widely examined with respect to sensation of self-produced stimuli, its role in the sequential production of discrete forces has not been extensively studied. The objective of the present experiment was to further investigate the force escalation effect by examining the sequential force production task in two predictable environments where force targets progressively changed between 8 and 16N. In one environment target force magnitudes continually increased at a predictable rate, while in the second target force magnitudes decreased at the same rate. Eight healthy participants produced a series of repetitive pinch grip forces in time to a metronome at a frequency of 2Hz. Visual feedback of force output was removed 10s in to the trial, with participants performing continued responses for the remaining 20s. Following removal of visual feedback participants rapidly accrued errors in force magnitude, but slopes of the peak force series did not differ from those of the target series. Errors in magnitude were bi-directional, showing dependence on the increasing or decreasing environment in which the task was performed. The observed escalation and de-escalation effect can both be attributed to central predictive mechanisms and the force salience effect in reafference. [Copyright &y& Elsevier]

For the past half century, the sliding filament-based cross-bridge theory has been the cornerstone of our understanding of how muscles contract. According to this theory, active force can only occur if there is overlap between the contractile filaments, actin and myosin. Otherwise, forces are thought to be caused by passive structural elements and are assumed to vary solely because of the length of the muscle. We observed increases in muscle force by a factor of 3 to 4 above the purely passive forces for activated and stretched myofibrils in the absence of actin-myosin overlap. We show that this dramatic increase in force is crucially dependent on the presence of the structural protein titin, cannot be explained with calcium activation, and is regulated by actin-myosin-based cross-bridge forces before stretching. We conclude from these observations that titin is a strong regulator of muscle force and propose that this regulation is based on cross-bridge force-dependent titin-actin interactions. These results suggest a mechanism for stability of sarcomeres on the "inherently unstable" descending limb of the force-length relationship, and they further provide an explanation for the protection of muscles against stretch-induced muscle injuries. [ABSTRACT FROM AUTHOR]

While much is known about sequential effects in motor timing, less is understood about whether movement parameters such as force show sequential dependencies. In this study, we examined the effect of timing constraints on repetitive unimanual force production sequences. Ten healthy participants produced a series of pinch grip forces in time to a metronome and to visually specified force amplitudes. Either visual feedback of force produced or the auditory metronome removed 10 s into the experimental trial, with participants performing continued responses for the remaining 20 s. In the continuation trials, a negative lag-1 autocorrelation in the inter-response intervals (IRIs) was observed as is commonly seen in motor timing tasks. However, removal of visual feedback resulted in a systematic increase in mean force output through the course of the trial, resulting in positive lag-1 autocorrelation values. An interaction was found between mean IRI and peak force (PF) magnitude, with greater force variability seen for the larger intervals. However, the imposition of dual force and timing constraints had no effect either on the underlying variability of the PF or on the IRIs. The results are discussed in the context of force and time being independently specified components of a generalized motor program. [ABSTRACT FROM AUTHOR]

The purpose of the present experiment was to examine whether the previously observed exaggerated isometric force production in changed-Gz during parabolic flight (Mierau et al. 2008) can be explained by a higher computational demand and, thus, inadequate allocation of the brain's computational resources to the task. Subjects (n = 12) were tested during the micro-Gz, high-Gz and normal-Gz episodes of parabolic flight. They produced isometric forces of different magnitudes and directions, according to visually prescribed vectors with their right, dominant hand and performed a choice reaction-time task with their left hand. Tasks were performed either separately (single-task) or simultaneously (dual-task). Dual-task interference was present for both tasks, indicating that each task was resources-demanding. However, this interference remained unaffected by the Gz-level. It was concluded that exaggerated force production in changed-Gz is probably not related to inadequate allocation of the brain's computational resources to the force production task. Statement of Relevance: The present study shows that deficient motor performance in changed-Gz environments (both micro-Gz and high-Gz) is not necessarily related to inadequate computational resources allocation, as was suggested in some previous studies. This finding is of great relevance not only for fundamental research, but also for the training and safety of humans operating in changed-Gz environments, such as astronauts and jet pilots. [ABSTRACT FROM AUTHOR]

Abstract: The present study investigated how trait anxiety alters the balance between attentional control systems to impact performance of a discrete preplanned goal-directed motor task. Participants executed targeted force contractions (engaging the goal-directed attentional system) at the offset of emotional and non-emotional distractors (engaging the stimulus-driven attentional system). High and low anxious participants completed the protocol at two target force levels (10% and 35% of maximum voluntary contraction). Reaction time (RT), performance accuracy, and rate of change of force were calculated. Expectations were confirmed at the 10% but not the 35% target force level: (1) high anxiety was associated with slower RTs, and (2) threat cues lead to faster RTs independently of trait anxiety. These new findings suggest that motor efficiency, but not motor effectiveness is compromised in high relative to low anxious individuals. We conclude that increased stimulus-driven attentional control interferes with movements that require greater attentional resources. [Copyright &y& Elsevier]