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101. Event-Related Potentials

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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102. Energy Cost of Locomotion

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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103. Eisenmenger Physiology

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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104. Exercise-Induced Intestinal Hypoperfusion and Subsequent Intestinal Damage

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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105. Energy Intake

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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106. Exercise and Neurocognitive Function

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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107. Excitation–Contraction Coupling

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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108. Exercise-Associated Functional Hypothalamic Amenorrhea

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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109. Excess Postexercise Oxygen Consumption

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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110. Exercise and Risk of Upper Respiratory Tract Infection

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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111. Exercise and Mental Health

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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112. Energy Cost of Running

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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113. Enteral Nutrition

Author

Proske, Uwe, primary, Morgan, David L., additional, Hew-Butler, Tamara, additional, Keenan, Kevin G., additional, Enoka, Roger M., additional, Sixt, Sebastian, additional, Niebauer, Josef, additional, Hawley, John A., additional, Gibala, Martin J., additional, Myburgh, Kathryn H., additional, Capelli, C., additional, Zamparo, P., additional, Kang, Jie, additional, Löllgen, Herbert, additional, Löllgen, Ruth, additional, Jelkmann, Wolfgang, additional, Scott, Christopher B., additional, Smyrnias, Ioannis, additional, Bootman, Martin D., additional, Roderick, H. Llewelyn, additional, Myers, Jonathan N., additional, Brubaker, Peter H., additional, Carlsen, Kai-Håkon, additional, Kjær, Michael, additional, Sim, Marc, additional, Peeling, Peter, additional, Dawson, Brian, additional, and Trinder, Debbie, additional

Published
2012
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118. Enhanced pyruvate dehydrogenase activity does not affect muscle [O.sub.2] uptake at onset of intense exercise in humans

Author

Bangsbo, Jens, Gibala, Martin J., Krustrup, Peter, Gonzalez-Alonzo, Jose, and Saltin, Bengt

Subjects
Phosphocreatine -- Physiological aspects, Blood flow -- Measurement, Exercise -- Physiological aspects, Biological sciences
Abstract

Enhanced pyruvate dehydrogenase activity does not affect muscle [O.sub.2] uptake at onset of intense exercise in humans. Am J Physiol Regulatory Integrative Comp Physiol 282: R273-R280, 2002.--It has been proposed that the activation state of pyruvate dehydrogenase (PDH) may influence the rate of skeletal muscle [O.sub.2] uptake during the initial phase of exercise; however, this has not been directly tested in humans. To remedy this, we used dichloroacetate (DCA) infusion to increase the active form of PDH (PD[H.sub.a]) and, subsequently, measured leg [O.sub.2] uptake and markers of anaerobic ATP provision during conditions of intense dynamic exercise, when the rate of muscle [O.sub.2] uptake would be very high. Six subjects performed brief bouts of one-legged knee-extensor exercise at ~110% of thigh peak [O.sub.2] uptake (65.3 [+ or -] 3.7 W) on several occasions: under noninfused control (Con) and DCA-supplemented conditions. Needle biopsy samples from the vastus lateralis muscle were obtained at rest and after 5 s, 15 s, and 3 min of exercise during both experimental conditions. In addition, thigh blood flow and femoral arteriovenous differences for [O.sub.2] and lactate were measured repeatedly during the 3-min work bouts (Con and DCA) to calculate thigh [O.sub.2] uptake and lactate release. After DCA administration, PD[H.sub.a] was four- to eightfold higher (P < 0.05) than Con at rest, and PD[H.sub.a] remained ~130% and 1.00% higher (P < 0.05) after 5 and 15 s of exercise, respectively. There was no difference between trials after 3 min. Despite the marked difference in PD[H.sub.a] between trials at rest and during the initial phase of exercise, thigh [O.sub.2] uptake was the same. In addition, muscle phosphocreatine utilization and lactate production were similar after 5 s, 15 s, and 3 min of exercise in DCA and Con. The present findings demonstrate that increasing PD[H.sub.a] does not alter muscle [O.sub.2] uptake and anaerobic ATP provision during the initial phase of intense dynamic knee-extensor exercise in humans. blood flow; lactate; creatine phosphate; dichloroacetate

Published
2002

123. Regulation of skeletal muscle amino acid metabolism during exercise

Author

Gibala, Martin J.

Subjects
Striated muscle -- Physiological aspects, Exercise -- Physiological aspects, Amino acid metabolism -- Physiological aspects, Energy metabolism -- Physiological aspects, Enzymes -- Physiological aspects, Adenosine triphosphatase -- Physiological aspects, Fatigue -- Physiological aspects, Food/cooking/nutrition, Sports and fitness
Abstract

This article examines the physiological processes involved in the metabolism of amino acids in skeletal muscle during intense exercise. Findings indicate that amino acid metabolism influences metabolites involved in the tricarboxylic acid cycle which play a role in mediating aerobic energy production and fatigue in skeletal muscle.

Published
2001

126. Untapping the Health Enhancing Potential of Vigorous Intermittent Lifestyle Physical Activity (VILPA): Rationale, Scoping Review, and a 4-Pillar Research Framework

Author

Stamatakis, Emmanuel, primary, Huang, Bo-Huei, additional, Maher, Carol, additional, Thøgersen-Ntoumani, Cecilie, additional, Stathi, Afroditi, additional, Dempsey, Paddy C., additional, Johnson, Nathan, additional, Holtermann, Andreas, additional, Chau, Josephine Y., additional, Sherrington, Catherine, additional, Daley, Amanda J., additional, Hamer, Mark, additional, Murphy, Marie H., additional, Tudor-Locke, Catrine, additional, and Gibala, Martin J., additional

Published
2020
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133. PDH activation by dichloroacetate reduces TCA cycle intermediates at rest but not during exercise in humans

Author

Gibala, Martin J. and Saltin, Bengt

Subjects
Exercise -- Physiological aspects, Oxidation, Physiological -- Physiological aspects, Muscles -- Physiological aspects, Biological sciences
Abstract

The effect of dichloroacetate (DCA) infusion on the concentrations of muscle tricarboxylic acid cycle intermediates (TCAI) at rest and during dynamic knee extensor exercise in humans has been studied. Six subjects did moderate leg kicking exercises for 15 min. that was immediately followed by intense exercixe until exhaustion after being given saline or DCA infusions. Results indicate that DCA diminished TCAI pool size at rest by increasing the flux through the pyruvate dehydrogenase and diverting pyruvate away from anaplerotic pathways.

Published
1999

144. Tricarboxylic acid cycle intermediate pool size and estimated cycle flux in human muscle during exercise

Author

Gibala, Martin J., MacLean, Dave A., Graham, Terry E., and Saltin, Bengt

Subjects
Muscles -- Physiological aspects, Exercise -- Physiological aspects, Metabolism -- Research, Amino acids -- Research, Carboxylic acids -- Research, Dehydrogenases -- Research, Biological sciences
Abstract

Six males were required to perform moderate leg extensor exercise for 10 min and then intense exercise until exhaustion to examine the relationship between tricarboxylic acid cycle (TCA) intermediate (TCAI) pool size, TCA cycle flux and pyruvate dehydrogenase activity in human skeletal muscle. It was observed that the TCA cycle flux can greatly increase even if there is a relatively small change in the TCAI pool size. The finding suggests that the imbalance between the rate of pyruvate production and the rate of oxidation in the TCA cycle causes the increase in TCAI during exercise.

Published
1998

148. Tricarboxylic acid cycle intermediates in human muscle at rest and during prolonged cycling

Author

Gibala, Martin J., Tarnopolsky, Mark A., and Graham, Terry E.

Subjects
Tissue respiration -- Physiological aspects, Muscles -- Physiological aspects, Exercise -- Physiological aspects, Biological sciences
Abstract

The levels of tricarboxylic acid cycle intermediates (TACI) from eight healthy human males were analyzed to determine the effects of prolonged exercise on TCA cycle pool expansion. TCAI concentrations in the skeletal muscle of human subjects exhibited peak expansion within five minutes of submaximal exercise with a rate of expansion that is higher than rodent skeletal muscles. Furthermore, the magnitude of TCAI intermediates in humans was not uniform during exercise.

Published
1997

149. Nutritional status affects branched-chain oxidized-chain oxoacid dehydrogenase activity during exercise in humans

Author

Jackman, Michelle L., Gibala, Martin J., Hultman, Eric, and Graham, Terry E.

Subjects
Muscles -- Physiological aspects, Branched chain amino acids -- Physiological aspects, Exercise -- Physiological aspects, Dehydrogenases -- Physiological aspects, Glycogen -- Physiological aspects, Biological sciences
Abstract

The effects carbohydrate and branched-chain amino acid (BCAA) availability on the activity of branched-chain oxoacid dehydrogenase (BCOAD) was analyzed during prolonged exercise in healthy individuals. Analysis of muscle metabolism during prolonged exercise indicated the role of low glycogen concentration in increasing the levels of BCOAD in active state. Furthermore, muscle endurance was not enhanced by BCAA supplementation during low-carbohydrate conditions.

Published
1997

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