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2,741 results on '"Gladman, Dafna D"'

101. LO-024 Association between severe non-adherence to hydroxychloroquine and SLE flares, damage, and mortality in 660 patients from the SLICC inception cohort

Author

Nguyen, Yann, primary, Blanchet, Benoît, additional, Urowitz, Murray B, additional, Hanly, John G, additional, Gordon, Caroline, additional, Bae, Sang-Cheol, additional, Romero-Diaz, Juanita, additional, Sanchez-Guerrero, Jorge, additional, Clarke, Ann E, additional, Bernatsky, Sasha, additional, Wallace, Daniel J, additional, Isenberg, David A, additional, Rahman, Anisur, additional, Merrill, Joan T, additional, Fortin, Paul R, additional, Gladman, Dafna D, additional, Bruce, Ian N, additional, Petri, Michelle, additional, Ginzler, Ellen M, additional, Dooley, Mary Anne, additional, Ramsey-Goldman, Rosalind, additional, Manzi, Susan, additional, Jönsen, Andreas, additional, Alarcón, Graciela S, additional, Vollenhoven, Ronald FVan, additional, Aranow, Cynthia, additional, Guern, Véronique Le, additional, Mackay, Meggan, additional, Ruiz-Irastorza, Guillermo, additional, Lin, Sam, additional, Inanc, Murat, additional, Kalunian, Kenneth C, additional, Jacobsen, Søren, additional, Peschken, Christine A, additional, Kamen, Diane L, additional, Askanase, Anca, additional, Buyon, Jill, additional, and Costedoat-Chalumeau, Nathalie, additional

Published
2023
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102. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Author

Tsoi, Lam C, Spain, Sarah L, Knight, Jo, Ellinghaus, Eva, Stuart, Philip E, Capon, Francesca, Ding, Jun, Li, Yanming, Tejasvi, Trilokraj, Gudjonsson, Johann E, Kang, Hyun M, Allen, Michael H, McManus, Ross, Novelli, Giuseppe, Samuelsson, Lena, Schalkwijk, Joost, Ståhle, Mona, Burden, A David, Smith, Catherine H, Cork, Michael J, Estivill, Xavier, Bowcock, Anne M, Krueger, Gerald G, Weger, Wolfgang, Worthington, Jane, Tazi-Ahnini, Rachid, Nestle, Frank O, Hayday, Adrian, Hoffmann, Per, Winkelmann, Juliane, Wijmenga, Cisca, Langford, Cordelia, Edkins, Sarah, Andrews, Robert, Blackburn, Hannah, Strange, Amy, Band, Gavin, Pearson, Richard D, Vukcevic, Damjan, Spencer, Chris CA, Deloukas, Panos, Mrowietz, Ulrich, Schreiber, Stefan, Weidinger, Stephan, Koks, Sulev, Kingo, Külli, Esko, Tonu, Metspalu, Andres, Lim, Henry W, Voorhees, John J, Weichenthal, Michael, Wichmann, H Erich, Chandran, Vinod, Rosen, Cheryl F, Rahman, Proton, Gladman, Dafna D, Griffiths, Christopher EM, Reis, Andre, Kere, Juha, Nair, Rajan P, Franke, Andre, Barker, Jonathan NWN, Abecasis, Goncalo R, Elder, James T, and Trembath, Richard C

Subjects
Genetics, Autoimmune Disease, Human Genome, Psoriasis, Aetiology, 2.1 Biological and endogenous factors, Skin, CARD Signaling Adaptor Proteins, Core Binding Factor Alpha 3 Subunit, DEAD Box Protein 58, DEAD-box RNA Helicases, GTPase-Activating Proteins, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Guanylate Cyclase, Humans, Immunity, Innate, Membrane Proteins, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Receptors, Immunologic, STAT3 Transcription Factor, T-Lymphocytes, White People, Collaborative Association Study of Psoriasis, Genetic Analysis of Psoriasis Consortium, Psoriasis Association Genetics Extension, Wellcome Trust Case Control Consortium 2, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.

Published
2012

104. Increased risk of severe generalized pustular psoriasis due to tuberculosis screening delay for spesolimab initiation

Author

Gladman, Dafna D., Reddy, Soumya, Merola, Joseph, Calabrese, Cassandra, Lebwohl, Mark, Kindred, Chesahna, Miller, Lauren, Kircik, Leon, Liu, Clive, Lewitt, G. Michael, Lee, Lara Wine, Desai, Seemal, Van Voorhees, Abby, Glick, Brad P., Soung, Jennifer, Hackley, Madison, Thampy, Daphne, Waseh, Shayan, Feldman, Steven R., Blauvelt, Andrew, Weinberg, Jeffrey M., Schwartzman, Sergio, Liao, Wilson, Prussick, Ronald, Cohen, Jeffrey M., and Hsu, Sylvia

Published
2024
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108. Systemic Lupus Erythematosus Women with Lupus Nephritis in Pregnancy Therapeutic Challenge (SWITCH): The Systemic Lupus International Collaborating Clinics experience

Author

Lee, Joo-Young E, primary, Mendel, Arielle, additional, Askanase, Anca, additional, Bae, Sang-Cheol, additional, Buyon, Jill P, additional, Clarke, Ann Elaine, additional, Costedoat-Chalumeau, Nathalie, additional, Fortin, Paul R, additional, Gladman, Dafna D, additional, Ramsey-Goldman, Rosalind, additional, Hanly, John G, additional, Inanç, Murat, additional, Isenberg, David Alan, additional, Mak, Anselm, additional, Mosca, Marta, additional, Petri, Michelle, additional, Rahman, Anisur, additional, Sanchez-Guerrero, Jorge, additional, Urowitz, Murray, additional, Wallace, Daniel J, additional, Bernatsky, Sasha, additional, and Vinet, Évelyne, additional

Published
2023
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110. Machine learning identifies clusters of longitudinal autoantibody profiles predictive of systemic lupus erythematosus disease outcomes

Author

Choi, May Yee, primary, Chen, Irene, additional, Clarke, Ann Elaine, additional, Fritzler, Marvin J, additional, Buhler, Katherine A, additional, Urowitz, Murray, additional, Hanly, John, additional, St-Pierre, Yvan, additional, Gordon, Caroline, additional, Bae, Sang-Cheol, additional, Romero-Diaz, Juanita, additional, Sanchez-Guerrero, Jorge, additional, Bernatsky, Sasha, additional, Wallace, Daniel J, additional, Isenberg, David Alan, additional, Rahman, Anisur, additional, Merrill, Joan T, additional, Fortin, Paul R, additional, Gladman, Dafna D, additional, Bruce, Ian N, additional, Petri, Michelle, additional, Ginzler, Ellen M, additional, Dooley, Mary Anne, additional, Ramsey-Goldman, Rosalind, additional, Manzi, Susan, additional, Jönsen, Andreas, additional, Alarcón, Graciela S, additional, van Vollenhoven, Ronald F, additional, Aranow, Cynthia, additional, Mackay, Meggan, additional, Ruiz-Irastorza, Guillermo, additional, Lim, Sam, additional, Inanc, Murat, additional, Kalunian, Kenneth, additional, Jacobsen, Søren, additional, Peschken, Christine, additional, Kamen, Diane L, additional, Askanase, Anca, additional, Buyon, Jill P, additional, Sontag, David, additional, and Costenbader, Karen H, additional

Published
2023
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116. Proceedings of the GRAPPA 2022 Executive Retreat.

Author

Cheok Kuan Ng, Beverly, Jadon, Deepak, Adebajo, Adewale, Ayan, Gizem, Callis Duffin, Kristina, Chandran, Vinod, Coates, Laura C., D'Agostino, Maria Antonietta, de Vlam, Kurt, Deodhar, Atul, Eder, Lihi, Garg, Amit, Gladman, Dafna D., Goel, Niti, Gottlieb, Alice B., Husni, M. Elaine, Katz, Arnon, Kavanaugh, Arthur, Lubrano, Ennio, and Mease, Philip J.

Published
2023
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120. Sex differences in the efficacy, safety and persistence of patients with psoriatic arthritis treated with tofacitinib: a post-hoc analysis of phase 3 trials and long-term extension

Author

Eder, Lihi, primary, Gladman, Dafna D, additional, Mease, Philip, additional, Pollock, Remy A, additional, Luna, Rayana, additional, Aydin, Sibel Z, additional, Ogdie, Alexis, additional, Polachek, Ari, additional, Gruben, David, additional, Cadatal, Mary Jane, additional, Kinch, Cassandra, additional, and Strand, Vibeke, additional

Published
2023
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121. Cardiac Magnetic Resonance Imaging T1 and T2 Mapping in Systemic Lupus Erythematosus in Relation to Antimalarial Treatment

Author

Shalmon, Tamar, primary, Thavendiranathan, Paaladinesh, additional, Seidman, Michael A., additional, Wald, Rachel M., additional, Karur, Gauri Rani, additional, Harvey, Paula J., additional, Akhtari, Shadi, additional, Osuntokun, Tosin, additional, Tselios, Kostantinos, additional, Gladman, Dafna D., additional, and Hanneman, Kate, additional

Published
2023
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123. Assessing the Costs of Neuropsychiatric Disease in the Systemic Lupus International Collaborating Clinics (SLICC) Cohort using Multistate Modelling

Author

Clarke, Ann E., primary, Hanly, John G., additional, Urowitz, Murray B., additional, St. Pierre, Yvan, additional, Gordon, Caroline, additional, Bae, Sang‐Cheol, additional, Romero‐Diaz, Juanita, additional, Sanchez‐Guerrero, Jorge, additional, Bernatsky, Sasha, additional, Wallace, Daniel J., additional, Isenberg, David A., additional, Rahman, Anisur, additional, Merrill, Joan T., additional, Fortin, Paul R., additional, Gladman, Dafna D., additional, Bruce, Ian N., additional, Petri, Michelle, additional, Ginzler, Ellen M., additional, Dooley, Mary Anne, additional, Ramsey‐Goldman, Rosalind, additional, Manzi, Susan, additional, Jönsen, Andreas, additional, Alarcón, Graciela S., additional, Van Vollenhoven, Ronald F., additional, Aranow, Cynthia, additional, Mackay, Meggan, additional, Ruiz‐Irastorza, Guillermo, additional, Lim, S. Sam, additional, Inanc, Murat, additional, Kalunian, Kenneth C., additional, Jacobsen, Soren, additional, Peschken, Christine A., additional, Kamen, Diane L., additional, Askanase, Anca, additional, and Farewell, Vernon, additional

Published
2023
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124. Genetics of osteonecrosis in children and adults with systemic lupus erythematosus

Author

Webber, Declan, primary, Cao, Jingjing, additional, Dominguez, Daniela, additional, Gladman, Dafna D, additional, Knight, Andrea, additional, Levy, Deborah M, additional, Liao, Fangming, additional, Ng, Lawrence, additional, Paterson, Andrew D, additional, Touma, Zahi, additional, Wither, Joan, additional, Urowitz, Murray, additional, Silverman, Earl D, additional, and Hiraki, Linda T, additional

Published
2023
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126. Association between baseline cardiovascular risk and incidence rates of major adverse cardiovascular events and malignancies in patients with psoriatic arthritis and psoriasis receiving tofacitinib

Author

Kristensen, Lars E., primary, Strober, Bruce, additional, Poddubnyy, Denis, additional, Leung, Ying-Ying, additional, Jo, Hyejin, additional, Kwok, Kenneth, additional, Vranic, Ivana, additional, Fleishaker, Dona L., additional, Fallon, Lara, additional, Yndestad, Arne, additional, and Gladman, Dafna D., additional

Published
2023
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129. sj-docx-1-tab-10.1177_1759720X221149965 – Supplemental material for Association between baseline cardiovascular risk and incidence rates of major adverse cardiovascular events and malignancies in patients with psoriatic arthritis and psoriasis receiving tofacitinib

Author

Kristensen, Lars E., Strober, Bruce, Poddubnyy, Denis, Leung, Ying-Ying, Jo, Hyejin, Kwok, Kenneth, Vranic, Ivana, Fleishaker, Dona L., Fallon, Lara, Yndestad, Arne, and Gladman, Dafna D.

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-docx-1-tab-10.1177_1759720X221149965 for Association between baseline cardiovascular risk and incidence rates of major adverse cardiovascular events and malignancies in patients with psoriatic arthritis and psoriasis receiving tofacitinib by Lars E. Kristensen, Bruce Strober, Denis Poddubnyy, Ying-Ying Leung, Hyejin Jo, Kenneth Kwok, Ivana Vranic, Dona L. Fleishaker, Lara Fallon, Arne Yndestad and Dafna D. Gladman in Therapeutic Advances in Musculoskeletal Disease

Published
2023
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131. Persistence of Biologics in the Treatment of Psoriatic Arthritis: Data From a Large Hospital‐BasedLongitudinal Cohort

Author

Rida, Mohamad‐Ali, Lee, Ker‐Ai, Chandran, Vinod, Cook, Richard J., and Gladman, Dafna D.

Abstract

To analyze the trends in biologics use at a specialized center over a period of 20 years. We performed a retrospective analysis of 571 patients diagnosed with psoriatic arthritis enrolled in the Toronto cohort who initiated biologic therapy between January 1, 2000, and July 7, 2020. The probability of drug persistence over time was estimated nonparametrically. The time to discontinuation of first and second treatment was analyzed using Cox regression models, whereas a semiparametric failure time model with a gamma frailty was used to analyze the discontinuation of treatment over successive administrations of biologic therapy. The highest 3‐year persistence probability was observed with certolizumab when used as first biologic treatment, while interleukin‐17 inhibitors had the lowest probability. However, when used as second medication, certolizumab had the lowest drug survival even when accounting for selection bias. Depression and/or anxiety were associated with a higher rate of drug discontinuation due to all causes (relative risk [RR] 1.68, P= 0.01), while having higher education was associated with lower rates (RR 0.65, P= 0.03). In the analysis accommodating multiple courses of biologics, a higher tender joint count was associated with a higher rate of discontinuation due to all causes (RR 1.02, P= 0.01). Older age at the start of first treatment was associated with a higher rate of discontinuation due to side effects (RR 1.03, P= 0.01), while obesity had a protective role (RR 0.56, P= 0.05). Persistence in taking biologics depends on whether the biologic was used as first or second treatment. Depression and anxiety, higher tender joint count, and older age lead to drug discontinuation.

Published
2023
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133. Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients

Author

Patrick, Matthew T., Stuart, Philip E., Raja, Kalpana, Gudjonsson, Johann E., Tejasvi, Trilokraj, Yang, Jingjing, Chandran, Vinod, Das, Sayantan, Callis-Duffin, Kristina, Ellinghaus, Eva, Enerbäck, Charlotta, Esko, Tõnu, Franke, Andre, Kang, Hyun M., Krueger, Gerald G., Lim, Henry W., Rahman, Proton, Rosen, Cheryl F., Weidinger, Stephan, Weichenthal, Michael, Wen, Xiaoquan, Voorhees, John J., Abecasis, Gonçalo R., Gladman, Dafna D., Nair, Rajan P., Elder, James T., and Tsoi, Lam C.

Published
2018
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134. Evaluating the Construct of Damage in Systemic Lupus Erythematosus

Author

Johnson, Sindhu R., primary, Gladman, Dafna D., additional, Brunner, Hermine I., additional, Isenberg, David, additional, Clarke, Ann E., additional, Barber, Megan R. W., additional, Arnaud, Laurent, additional, Fortin, Paul R., additional, Mosca, Marta, additional, Voskuyl, Alexandre E., additional, Manzi, Susan, additional, Aranow, Cynthia, additional, Askanase, Anca, additional, Alarcón, Graciela S., additional, Bae, Sang‐Cheol, additional, Costedoat‐Chalumeau, Nathalie, additional, English, Jessica A., additional, Pons‐Estel, Guillermo J., additional, Pons‐Estel, Bernardo A., additional, Gilman, Rebecca, additional, Ginzler, Ellen M., additional, Hanly, John G., additional, Jacobsen, Soren, additional, Kalunian, Kenneth, additional, Kamen, Diane L., additional, Lambalgen, Chynace, additional, Legge, Alexandra, additional, Lim, S. Sam, additional, Mak, Anselm, additional, Morand, Eric F., additional, Peschken, Christine A., additional, Petri, Michelle, additional, Rahman, Anisur, additional, Ramsey‐Goldman, Rosalind, additional, Reynolds, John A., additional, Romero‐Diaz, Juanita, additional, Ruiz‐Irastorza, Guillermo, additional, Sanchez‐Guerrero, Jorge, additional, Svenungsson, Elisabet, additional, Touma, Zahi, additional, Urowitz, Murray, additional, Vinet, Evelyne, additional, van Vollenhoven, Ronald F., additional, Waldhauser, Heather, additional, Wallace, Daniel J., additional, Zoma, Asad, additional, and Bruce, Ian N., additional

Published
2022
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138. 102 M-Phase Phosphoprotein 1 (MPP-1) Autoantibodies as a Potential Biomarker for Cranial Neuropathies in an International SLE Inception Cohort

Author

Krustev, Eugene, primary, Hanly, John G, additional, Chin, Ricky, additional, Buhler, Katherine, additional, Cardwell, Francesca, additional, Urowitz, Murray B, additional, Gordon, Caroline, additional, Bae, Sang-Cheol, additional, Romero-Diaz, Juanita, additional, Sanchez-Guerrero, Jorge, additional, Bernatsky, Sasha, additional, Wallace, Daniel J, additional, Isenberg, David A, additional, Rahman, Anisur, additional, Merrill, Joan T, additional, Fortin, Paul R, additional, Gladman, Dafna D, additional, Bruce, Ian N, additional, Petri, Michelle, additional, Ginzler, Ellen M, additional, Dooley, Mary Anne, additional, Ramsey-Goldman, Rosalind, additional, Manzi, Susan, additional, Jönsen, Andreas, additional, Alarcón, Graciela S, additional, Vollenhoven, Ronald F van, additional, Aranow, Cynthia, additional, Mackay, Meggan, additional, Ruiz-Irastorza, Guillermo, additional, Lim, Sam, additional, Inanc, Murat, additional, Kalunian, Kenneth C, additional, Jacobsen, Søren, additional, Peschken, Christine A, additional, Kamen, Diane L, additional, Askanase, Anca, additional, Buyon, Jill, additional, Fritzler, Marvin J, additional, Clarke, Ann E, additional, and Choi, May Y, additional

Published
2022
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140. 603 Remission and low disease activity are associated with lower health care costs in an international inception cohort of patients with systemic lupus erythematosus

Author

Clarke, Ann E, primary, Ugarte-Gil, Manuel Francisco, additional, Barber, Megan RW, additional, Hanly, John G, additional, Urowitz, Murray B, additional, Pierre, Yvan St, additional, Gordon, Caroline, additional, Bae, Sang-Cheol, additional, Romero-Diaz, Juanita, additional, Sanchez-Guerrero, Jorge, additional, Bernatsky, Sasha, additional, Wallace, Daniel J, additional, Isenberg, David A, additional, Rahman, Anisur, additional, Merrill, Joan T, additional, Fortin, Paul R, additional, Gladman, Dafna D, additional, Bruce, Ian N, additional, Petri, Michelle, additional, Ginzler, Ellen M, additional, Dooley, Mary Anne, additional, Ramsey-Goldman, Rosalind, additional, Manzi, Susan, additional, Jönsen, Andreas, additional, Vollenhoven, Ronald FVan, additional, Aranow, Cynthia, additional, Mackay, Meggan, additional, Ruiz-Irastorza, Guillermo, additional, Sam Lim, S, additional, Inanc, Murat, additional, Kalunian, Kenneth C, additional, Jacobsen, Soren, additional, Peschken, Christine A, additional, Kamen, Diane L, additional, Askanase, Anca, additional, Pons-Estel, Bernardo A, additional, and Alarcón, Graciela S, additional

Published
2022
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149. Remission and low disease activity (LDA) prevent damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort

Author

Ugarte-Gil, Manuel Francisco, primary, Hanly, John, additional, Urowitz, Murray, additional, Gordon, Caroline, additional, Bae, Sang-Cheol, additional, Romero-Diaz, Juanita, additional, Sanchez-Guerrero, Jorge, additional, Bernatsky, Sasha, additional, Clarke, Ann Elaine, additional, Wallace, Daniel J, additional, Isenberg, David Alan, additional, Rahman, Anisur, additional, Merrill, Joan T, additional, Fortin, Paul R, additional, Gladman, Dafna D, additional, Bruce, Ian N, additional, Petri, Michelle, additional, Ginzler, Ellen M, additional, Dooley, Mary Anne, additional, Ramsey-Goldman, Rosalind, additional, Manzi, Susan, additional, Jönsen, Andreas, additional, van Vollenhoven, Ronald F, additional, Aranow, Cynthia, additional, Mackay, Meggan, additional, Ruiz-Irastorza, Guillermo, additional, Lim, Sam, additional, Inanc, Murat, additional, Kalunian, Ken, additional, Jacobsen, Søren, additional, Peschken, Christine, additional, Kamen, Diane L, additional, Askanase, Anca, additional, Pons-Estel, Bernardo A, additional, and Alarcón, Graciela S, additional

Published
2022
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