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1,428 results on '"Grothey, Axel"'

101. First-line (L1) therapy targeting EGFR in lung metastases (mets) of colorectal cancer (mCRC): An ARCAD pooled analysis.

Author

Shmueli, Einat Shacham, primary, Raeisi, Morteza, additional, Chibaudel, Benoist, additional, Maughan, Timothy S., additional, Douillard, Jean-Yves, additional, Van Cutsem, Eric, additional, Bokemeyer, Carsten, additional, Grothey, Axel, additional, Adams, Richard, additional, Zalcberg, John Raymond, additional, Yoshino, Takayuki, additional, Bachet, Jean-Baptiste, additional, Cohen, Romain, additional, Sharara, Lama, additional, Andre, Thierry, additional, Shi, Qian, additional, and De Gramont, Aimery, additional

Published
2022
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103. Metastatic Colorectal Cancer Outcomes by Age among ARCAD First- and Second-Line Clinical Trials

Author

MS Medische Oncologie, Cancer, McCleary, Nadine J., Harmsen, William S., Haakenstad, Ellana, Cleary, James M., Meyerhardt, Jeffrey A., Zalcberg, John, Adams, Richard, Grothey, Axel, Sobrero, Alberto F., Van Cutsem, Eric, Goldberg, Richard M., Peeters, Marc, Tabernero, Josep, Seymour, Matt, Saltz, Leonard B., Giantonio, Bruce J., Arnold, Dirk, Rothenberg, Mace L., Koopman, Miriam, Schmoll, Hans Joachim, Pitot, Henry C., Hoff, Paulo M., Tebbutt, Niall, Masi, Gianluca, Souglakos, John, Bokemeyer, Carsten, Heinemann, Volker, Yoshino, Takayuki, Chibaudel, Benoist, Degramont, Aimery, Shi, Qian, S Lichtman, Stuart M., MS Medische Oncologie, Cancer, McCleary, Nadine J., Harmsen, William S., Haakenstad, Ellana, Cleary, James M., Meyerhardt, Jeffrey A., Zalcberg, John, Adams, Richard, Grothey, Axel, Sobrero, Alberto F., Van Cutsem, Eric, Goldberg, Richard M., Peeters, Marc, Tabernero, Josep, Seymour, Matt, Saltz, Leonard B., Giantonio, Bruce J., Arnold, Dirk, Rothenberg, Mace L., Koopman, Miriam, Schmoll, Hans Joachim, Pitot, Henry C., Hoff, Paulo M., Tebbutt, Niall, Masi, Gianluca, Souglakos, John, Bokemeyer, Carsten, Heinemann, Volker, Yoshino, Takayuki, Chibaudel, Benoist, Degramont, Aimery, Shi, Qian, and S Lichtman, Stuart M.

Published
2022

104. Clinical Trial Endpoints in Metastatic Cancer: Using Individual Participant Data to Inform Future Trials Methodology

Author

MS Medische Oncologie, Cancer, Goldberg, Richard M, Adams, Richard, Buyse, Marc, Eng, Cathy, Grothey, Axel, André, Thierry, Sobrero, Alberto F, Lichtman, Stuart M, Benson, Al B, Punt, Cornelis J A, Maughan, Tim, Burzykowski, Tomasz, Sommeijer, Dirkje, Saad, Everardo D, Shi, Qian, Coart, Elisabeth, Chibaudel, Benoist, Koopman, Miriam, Schmoll, Hans-Joachim, Yoshino, Takayuki, Taieb, Julien, Tebbutt, Niall C, Zalcberg, John, Tabernero, Josep, Van Cutsem, Eric, Matheson, Alastair, de Gramont, Aimery, MS Medische Oncologie, Cancer, Goldberg, Richard M, Adams, Richard, Buyse, Marc, Eng, Cathy, Grothey, Axel, André, Thierry, Sobrero, Alberto F, Lichtman, Stuart M, Benson, Al B, Punt, Cornelis J A, Maughan, Tim, Burzykowski, Tomasz, Sommeijer, Dirkje, Saad, Everardo D, Shi, Qian, Coart, Elisabeth, Chibaudel, Benoist, Koopman, Miriam, Schmoll, Hans-Joachim, Yoshino, Takayuki, Taieb, Julien, Tebbutt, Niall C, Zalcberg, John, Tabernero, Josep, Van Cutsem, Eric, Matheson, Alastair, and de Gramont, Aimery

Published
2022

107. Efficacy of anti-epidermal growth factor receptor agents in patients with RAS wild-type metastatic colorectal cancer ≥ 70 years

Author

Papamichael, Demetris, primary, Lopes, Guilherme S., additional, Olswold, Curt L., additional, Douillard, Jean-Yves, additional, Adams, Richard A., additional, Maughan, Timothy S., additional, Van Cutsem, Eric, additional, Venook, Alan P., additional, Lenz, Heinz-Josef, additional, Heinemann, Volker, additional, Kaplan, Richard, additional, Bokemeyer, Carsten, additional, Chibaudel, Benoist, additional, Grothey, Axel, additional, Yoshino, Takayuki, additional, Zalcberg, John, additional, De Gramont, Aimery, additional, and Shi, Qian, additional

Published
2022
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108. Comprehensive Analysis of R-Spondin Fusions and RNF43 Mutations Implicate Novel Therapeutic Options in Colorectal Cancer

Author

Seeber, Andreas, primary, Battaglin, Francesca, additional, Zimmer, Kai, additional, Kocher, Florian, additional, Baca, Yasmine, additional, Xiu, Joanne, additional, Spizzo, Gilbert, additional, Novotny-Diermayr, Veronica, additional, Rieder, Dietmar, additional, Puccini, Alberto, additional, Swensen, Jeff, additional, Ellis, Michelle, additional, Goldberg, Richard M., additional, Grothey, Axel, additional, Shields, Anthony F., additional, Marshall, John L., additional, Weinberg, Benjamin A., additional, Sackstein, Paul E., additional, Lim, Kiat Hon, additional, Tan, Gek San, additional, Nabhan, Chadi, additional, Korn, W. Michael, additional, Amann, Arno, additional, Trajanoski, Zlatko, additional, Berger, Martin D., additional, Lou, Emil, additional, Wolf, Dominik, additional, and Lenz, Heinz-Josef, additional

Published
2022
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109. Trastuzumab deruxtecan (T-DXd; DS-8201) in patients (pts) with HER2-expressing metastatic colorectal cancer (mCRC): Final results from a phase 2, multicenter, open-label study (DESTINY-CRC01).

Author

Yoshino, Takayuki, primary, Di Bartolomeo, Maria, additional, Raghav, Kanwal Pratap Singh, additional, Masuishi, Toshiki, additional, Kawakami, Hisato, additional, Yamaguchi, Kensei, additional, Nishina, Tomohiro, additional, Wainberg, Zev A., additional, Elez, Elena, additional, Rodriguez, Javier, additional, Fakih, Marwan, additional, Ciardiello, Fortunato, additional, Saxena, Kapil, additional, Kobayashi, Kojiro, additional, Bako, Emarjola, additional, Okuda, Yasuyuki, additional, Meinhardt, Gerold, additional, Grothey, Axel, additional, and Siena, Salvatore, additional

Published
2022
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110. BREAKWATER: Randomized phase 3 study of encorafenib (enco) + cetuximab (cet) ± chemotherapy for first-line treatment (tx) of BRAF V600E-mutant (BRAFV600) metastatic colorectal cancer (mCRC).

Author

Kopetz, Scott, primary, Grothey, Axel, additional, Yaeger, Rona, additional, Ciardiello, Fortunato, additional, Desai, Jayesh, additional, Kim, Tae Won, additional, Maughan, Tim, additional, Van Cutsem, Eric, additional, Wasan, Harpreet Singh, additional, Yoshino, Takayuki, additional, Edwards, Michelle L., additional, Golden, Adele, additional, Gollerkeri, Ashwin, additional, and Tabernero, Josep, additional

Published
2022
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117. Clinical Trial Endpoints in Metastatic Cancer: Using Individual Participant Data to Inform Future Trials Methodology

Author

Goldberg, Richard M, primary, Adams, Richard, additional, Buyse, Marc, additional, Eng, Cathy, additional, Grothey, Axel, additional, André, Thierry, additional, Sobrero, Alberto F, additional, Lichtman, Stuart M, additional, Benson, Al B, additional, Punt, Cornelis J A, additional, Maughan, Tim, additional, Burzykowski, Tomasz, additional, Sommeijer, Dirkje, additional, Saad, Everardo D, additional, Shi, Qian, additional, Coart, Elisabeth, additional, Chibaudel, Benoist, additional, Koopman, Miriam, additional, Schmoll, Hans-Joachim, additional, Yoshino, Takayuki, additional, Taieb, Julien, additional, Tebbutt, Niall C, additional, Zalcberg, John, additional, Tabernero, Josep, additional, Van Cutsem, Eric, additional, Matheson, Alastair, additional, and de Gramont, Aimery, additional

Published
2021
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118. Multidisciplinary Provider Insights to Promote Adoption of Bispecific Antibodies to Treat Cancer in the Community

Author

Atembina, Limaya, primary, Boehmer, Leigh, additional, Terrell, Kelly, additional, Koka, Rima, additional, Janakiram, Murali, additional, Grothey, Axel, additional, Morris, Amy L, additional, Devarakonda, Srinivas, additional, Rogers, Barbara, additional, Kelly, Ronan, additional, Berdeja, Jesus, additional, and El Chaer, Firas, additional

Published
2021
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119. Association of Homologous Recombination-DNA Damage Response Gene Mutations with Immune Biomarkers in Gastroesophageal Cancers

Author

Cerniglia, Michael, primary, Xiu, Joanne, additional, Grothey, Axel, additional, Pishvaian, Michael J, additional, Baca, Yasmine, additional, Hwang, Jimmy J, additional, Marshall, John L, additional, VanderWalde, Ari M, additional, Shields, Anthony F, additional, Lenz, Heinz-Josef, additional, Korn, W. Michael, additional, Salem, Mohamed, additional, Philip, Philip A, additional, Goldberg, Richard M, additional, Zeng, Jia, additional, and Kim, Sunnie S, additional

Published
2021
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124. The IDEA (International Duration Evaluation of Adjuvant Chemotherapy) Collaboration: Prospective Combined Analysis of Phase III Trials Investigating Duration of Adjuvant Therapy with the FOLFOX (FOLFOX4 or Modified FOLFOX6) or XELOX (3 versus 6 months) Regimen for Patients with Stage III Colon Cancer: Trial Design and Current Status

Author

André, Thierry, Iveson, Timothy, Labianca, Roberto, Meyerhardt, Jeffrey A., Souglakos, Ioannis, Yoshino, Takayuki, Paul, James, Sobrero, Alberto, Taieb, Julien, Shields, Anthony F., Ohtsu, Atsushi, Grothey, Axel, Sargent, Daniel J., and for the IDEA Steering Committee

Published
2013
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125. Biomarker testing patterns and actionability in advanced non-small cell lung cancer (aNSCLC) at OneOncology (OneOnc).

Author

Vanderwalde, Ari M., primary, Ma, Esprit, additional, Yu, Elaine, additional, Szado, Tania, additional, Price, Richard, additional, Shah, Anuj, additional, Meyer, Craig S., additional, Abbass, Ibrahim M., additional, Grothey, Axel, additional, Staszewski, Harry, additional, Slater, Dennis, additional, Blakely, L. Johnetta, additional, and Schwartzberg, Lee S., additional

Published
2021
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126. NGS testing patterns in advanced non-small cell lung cancer (aNSCLC) and metastatic breast cancer (mBC): OneOncology (OO) sites compared to Flatiron Health Nationwide (NAT).

Author

Vanderwalde, Ari M., primary, Ma, Esprit, additional, Yu, Elaine, additional, Szado, Tania, additional, Price, Richard, additional, Shah, Anuj, additional, Meyer, Craig S., additional, Abbass, Ibrahim M., additional, Grothey, Axel, additional, Staszewski, Harry, additional, Slater, Dennis, additional, Blakely, L. Johnetta, additional, and Schwartzberg, Lee S., additional

Published
2021
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127. Reevaluating Disease-Free Survival as an Endpoint vs Overall Survival in Stage III Adjuvant Colon Cancer Trials

Author

Yin, Jun, primary, Salem, Mohamed E, additional, Dixon, Jesse G, additional, Jin, Zhaohui, additional, Cohen, Romain, additional, DeGramont, Aimery, additional, Van Cutsem, Eric, additional, Taieb, Julien, additional, Alberts, Steven R, additional, Wolmark, Norman, additional, Schmoll, Hans-Joachim, additional, Saltz, Leonard B, additional, George, Thomas J, additional, Goldberg, Richard R M, additional, Kerr, Rachel, additional, Lonardi, Sara, additional, Yoshino, Takayuki, additional, Yothers, Greg, additional, Grothey, Axel, additional, Andre, Thierry, additional, and Shi, Qian, additional

Published
2021
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128. BESPOKE study protocol: a multicentre, prospective observational study to evaluate the impact of circulating tumour DNA guided therapy on patients with colorectal cancer

Author

Kasi, Pashtoon Murtaza, primary, Sawyer, Sarah, additional, Guilford, Jessica, additional, Munro, Michelle, additional, Ellers, Sascha, additional, Wulff, Jacob, additional, Hook, Nicole, additional, Krinshpun, Shifra, additional, Koyen Malashevich, Allyson, additional, Malhotra, Meenakshi, additional, Rodriguez, Angel, additional, Moshkevich, Solomon, additional, Grothey, Axel, additional, Kopetz, Scott, additional, Billings, Paul, additional, and Aleshin, Alexey, additional

Published
2021
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130. Microsatellite instability in stage III colon cancer patients receiving fluoropyrimidine ± oxaliplatin: an

Author

Cohen, Romain, Taieb, Julien, Fiskum, Jack, Yothers, Greg, Goldberg, Richard, Yoshino, Takayuki, Alberts, Steven, Allegra, Carmen, De Gramont, Aimery, Seitz, Jean-Francois, O'Connell, Michael, Haller, Daniel, Wolmark, Norman, Erlichman, Charles, Zaniboni, Alberto, Lonardi, Sara, Kerr, Rachel, Grothey, Axel, Sinicrope, Franck, André, Thierry, Shi, Qian, Service d'Oncologie Médicale [CHU Saint -Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Mayo Clinic [Rochester], University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE), Center for Climate Systems Research [New York] (CCSR), Columbia University [New York], University of Tokyo [Kashiwa Campus], The University of Florida College of Medicine, Service d'Oncologie Médicale [Institut Hospitalier Franco-Britannique], Division of Medical Oncology - Institut Hospitalier Franco-Britannique, Service d'oncologie digestive et hépato-gastro-entérologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Hospital of the University of Pennsylvania (HUP), Perelman School of Medicine, University of Pennsylvania [Philadelphia]-University of Pennsylvania [Philadelphia], Fondazione Poliambulanza, Veneto Institute of Oncology IOV-IRCCS [Padua, Italy], University of Oxford [Oxford], and West German Cancer Center [Essen, Germany]

Subjects
deficient mismatch repair, oxaliplatin, microsatellite instability, [SDV.CAN]Life Sciences [q-bio]/Cancer, prognosis, neoplasms, digestive system diseases, Colon cancer
Abstract

International audience; PURPOSE:In patients with stage III colon cancer (CC) whose tumors demonstrate microsatellite instability (MSI), the efficacy of adjuvant fluoropyrimidine (FP) with or without oxaliplatin has not been clearly demonstrated and the prognostic value of MSI remains uncertain.MATERIALS AND METHODS:Individual patient data from the ACCENT database were used to evaluate the effect of FP with or without oxaliplatin on disease-free survival (DFS) and overall survival (OS) among patients with MSI stage III CC and the prognostic value of MSI in patients treated with FP plus oxaliplatin, by stratified Cox models adjusted for demographic and clinicopathological factors.RESULTS:MSI status was available for 5,457 patients (609 MSI, 11.2%; 4848 microsatellite stable [MSS], 88.8%) from 12 randomized clinical trials (RCTs). Oxaliplatin significantly improved OS of MSI patients from the two RCTs testing FP with or without oxaliplatin (n = 185; adjusted hazard ratio [aHR] = 0.52, 95% CI, 0.28 to 0.93). Among the 4,250 patients treated with FP plus oxaliplatin (461 MSI and 3789 MSS), MSI was associated with better OS in the N1 group compared with MSS (aHR = 0.66; 95% CI, 0.46 to 0.95) but similar survival in the N2 population (aHR = 1.13; 95% CI, 0.86 to 1.48; P interaction = .029). The main independent prognosticators of MSI patients treated with FP plus oxaliplatin were T stage (aHR = 2.09; 95% CI, 1.29 to 3.38) and N stage (aHR = 3.57; 95% CI, 2.32 to 5.48). Similar results were observed for DFS in all analyses.CONCLUSION:Adding oxaliplatin to FP improves OS and DFS in patients with MSI stage III CC. Compared with MSS, MSI patients experienced better outcomes in the N1 group but similar survival in the N2 group.

Published
2021
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132. Tumor-Informed Assessment of Molecular Residual Disease and Its Incorporation Into Practice for Patients With Early- and Advanced-Stage Colorectal Cancer (CRC-MRD Consortia)

Author

Kasi, Pashtoon M., Dayyani, Farshid, Morris, Van, Kopetz, Scott, Parikh, Aparna, Starr, Jason S., Cohen, Stacey A., Grothey, Axel, Lieu, Christopher, O'hara, Mark, Loranger, Kate, West-Brook, Laura, Sharma, Shruti, Tin, Antony S., Krinshpun, Shifra, Hook, Nicole, Zimmermann, Bemhard, Billings, Paul R., and Aleshin, Alexey

Subjects
Bristol-Myers Squibb Co., Eli Lilly and Co., Metastasis -- Care and treatment -- Diagnosis -- Development and progression, Colorectal cancer -- Diagnosis -- Care and treatment -- Development and progression, Health
Abstract

BACKGROUND. Circulating tumor DNA (ctDNA) testing (often referred to as liquid biopsies) can be used for the assessment of molecular residual disease (MRD) in patients with early-stage, advanced and/or metastatic [...]

Published
2020

143. sj-pdf-1-tam-10.1177_17588359211020547 – Supplemental material for Impact of geography on prognostic outcomes of 21,509 patients with metastatic colorectal cancer enrolled in clinical trials: an ARCAD database analysis

Author

Yin, Jun, Dawood, Shaheenah, Cohen, Romain, Meyers, Jeff, Zalcberg, John, Yoshino, Takayuki, Seymour, Matthew, Maughan, Tim, Saltz, Leonard, Van Cutsem, Eric, Venook, Alan, Schmoll, Hans-Joachim, Goldberg, Richard, Hoff, Paulo, Hecht, J. Randolph, Hurwitz, Herbert, Punt, Cornelis, Diaz Rubio, Eduard, Koopman, Miriam, Cremolini, Chiara, Heinemann, Volker, Tournigard, Christophe, Bokemeyer, Carsten, Fuchs, Charles, Tebbutt, Niall, Souglakos, John, Doulliard, Jean-Yves, Kabbinavar, Fairooz, Chibaudel, Benoist, de Gramont, Aimery, Shi, Qian, Grothey, Axel, and Adams, Richard

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-tam-10.1177_17588359211020547 for Impact of geography on prognostic outcomes of 21,509 patients with metastatic colorectal cancer enrolled in clinical trials: an ARCAD database analysis by Jun Yin, Shaheenah Dawood, Romain Cohen, Jeff Meyers, John Zalcberg, Takayuki Yoshino, Matthew Seymour, Tim Maughan, Leonard Saltz, Eric Van Cutsem, Alan Venook, Hans-Joachim Schmoll, Richard Goldberg, Paulo Hoff, J. Randolph Hecht, Herbert Hurwitz, Cornelis Punt, Eduard Diaz Rubio, Miriam Koopman, Chiara Cremolini, Volker Heinemann, Christophe Tournigard, Carsten Bokemeyer, Charles Fuchs, Niall Tebbutt, John Souglakos, Jean-Yves Doulliard, Fairooz Kabbinavar, Benoist Chibaudel, Aimery de Gramont, Qian Shi, Axel Grothey and Richard Adams in Therapeutic Advances in Medical Oncology

Published
2021
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148. Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer

Author

Loree, Jonathan M., primary, Wang, Yucai, additional, Syed, Muddassir A., additional, Sorokin, Alexey V., additional, Coker, Oluwadara, additional, Xiu, Joanne, additional, Weinberg, Benjamin A., additional, Vanderwalde, Ari M., additional, Tesfaye, Anteneh, additional, Raymond, Victoria M., additional, Miron, Benjamin, additional, Tarcic, Gabi, additional, Zelichov, Ori, additional, Broaddus, Russell R., additional, Ng, Patrick Kwok Shing, additional, Jeong, Kang Jin, additional, Tsang, Yiu Huen, additional, Mills, Gordon B., additional, Overman, Michael J., additional, Grothey, Axel, additional, Marshall, John L., additional, and Kopetz, Scott, additional

Published
2021
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149. Prognostic and Predictive Impact of Primary Tumor Sidedness for Previously Untreated Advanced Colorectal Cancer

Author

Yin, Jun, primary, Cohen, Romain, additional, Jin, Zhaohui, additional, Liu, Heshan, additional, Pederson, Levi, additional, Adams, Richard, additional, Grothey, Axel, additional, Maughan, Timothy S, additional, Venook, Alan, additional, Van Cutsem, Eric, additional, Punt, Cornelis, additional, Koopman, Miriam, additional, Falcone, Alfredo, additional, Tebbutt, Niall C, additional, Seymour, Matthew T, additional, Bokemeyer, Carsten, additional, Rubio, Eduardo Diaz, additional, Kaplan, Richard, additional, Heinemann, Volker, additional, Chibaudel, Benoist, additional, Yoshino, Takayuki, additional, Zalcberg, John, additional, Andre, Thierry, additional, De Gramont, Aimery, additional, Shi, Qian, additional, and Lenz, Heinz-Josef, additional

Published
2021
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150. Characteristics of patients (pts) and prognostic factors across treatment lines (TL) in metastatic colorectal cancer (mCRC): An analysis from the Analysis and Research in Cancers of the Digestive System (ARCAD) database.

Author

Bachet, Jean-Baptiste, primary, Chibaudel, Benoist, additional, Rakez, Manel, additional, Goldberg, Richard M., additional, Tebbutt, Niall C., additional, Van Cutsem, Eric, additional, Haller, Daniel G., additional, Hecht, J. Randolph Randolph, additional, Mayer, Robert J., additional, Lichtman, Stuart M., additional, Benson, Al, additional, Sobrero, Alberto F., additional, Tabernero, Josep, additional, Adams, Richard, additional, Zalcberg, John Raymond, additional, Grothey, Axel, additional, Yoshino, Takayuki, additional, Shi, Qian, additional, and De Gramont, Aimery, additional

Published
2021
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