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644 results on '"Gulisano, M."'

110. Stereotypy case

Author

Gulisano, M., Calì, P, and Rizzo, Renata

Published
2009

114. Anatomia dell'Uomo

Author

Ambrosi, G., Cantino, D., Castano, P., Correr, S., D'Este, L., Donato, R. F., Familiari, G., Fornai, F., Gulisano, M., Iannello, A., Magaudda, L., Marcello, M. F., Martelli, A. M., Pacini, P., Rende, M., Rossi, P., Sforza, C., Tacchetti, Carlo, Toni, R., Zummo, G., G., Ambrosi, D., Cantino, P., Castano, S., Correr, L., D'Este, R. F., Donato, G., Familiari, F., Fornai, M., Gulisano, A., Iannello, L., Magaudda, M. F., Marcello, A. M., Martelli, P., Pacini, M., Rende, P., Rossi, C., Sforza, Tacchetti, Carlo, R., Toni, and G., Zummo

Published
2008

115. Anatomia dell'apparato locomotore

Author

Barni, T., Di Baldassarre, A., Falcieri, E., Farina, F., Grandi, D., Grimaldi, P., Gulisano, M., Milani, Daniela, Riccirdi, G., and Tafuri, D.

Subjects
Articolazioni, Muscoli, Ossa
Published
2008

125. Anatomia Dell'Uomo

Author

Ambrosi, G, Cantino, D, Castano, P, Correr, S, D'Este, L, Donato, Rf, Familiari, G, Fornai, Francesco, Gulisano, M, Iannello, A, Magaudda, L, Marcello, Mf, Martelli, Am, Pacini, P, Rende, M, Rossi, P, Sforza, C, Tacchetti, C, Toni, R, and Zummo, G.

Published
2006

128. Anatomia dell'Uomo. Seconda Edizione

Author

Ambrosi, G., Cantino, D., Castano, P., Correr, S., D'Este, L., Donato, R. F., Familiari, G., Fornai, F., Gulisano, M., Iannello, A., Magaudda, Ludovico, Marcello, M. F., Martelli, A. M., Pacini, P., Rende, M., Rossi, P., Sforza, C., Tacchetti, C., Toni, R., and Zummo, G.

Published
2006

144. Is the percentage of stenosis of the internal carotid artery a reliable measure of the risk of ischemic stroke? A morphometric study by duplex ultrasound of aortic arch branches in 500 normal adults

Author

Macchi C, Rm, Lova, Miniati B, Gulisano M, CARLO PRATESI, Aa, Conti, and Gf, Gensini

Subjects
Adult, Aged, 80 and over, Male, Ultrasonography, Doppler, Duplex, Reproducibility of Results, Middle Aged, Risk Assessment, Severity of Illness Index, Brain Ischemia, Stroke, Predictive Value of Tests, Reference Values, Humans, Carotid Stenosis, Female, Aorta, Carotid Artery, Internal, Aged
Abstract

The percentage of stenosis has been considered for the last 20 years, and still continues to be, the main criterion of choice between a surgical and a medical treatment of the atherosclerotic lesions of the aortic arch branches, particularly as regards the internal carotid artery. On the other side, it has been demonstrated that the risk of adverse acute cerebrovascular events, besides being related to the characteristics of the plaque, such as softness, subintimal haemorrhage or surface ulcer, is strictly related to the actual residual lumen of the internal carotid artery. The pre-eminent role of the percentage of stenosis in the choice of the treatment, hence, presumes a narrow range of variation of the original calibre of the vessel, yet to be proven.Five-hundred normal adults underwent the measurement of the internal calibre of the aortic arch branches by duplex ultrasound in order to find out their actual range of variation.The range of variation of the internal calibre of the aortic arch branches, expressed as the ratio between the maximum and the minimum value found for each vessel, was very wide in all cases (from 180% for the right common carotid artery to 340% for the right vertebral artery). With reference to the internal carotid arteries, the range of variation was 219% for the right internal carotid artery and 241% for the left internal carotid arteries.Due to the wide range of variation of the original calibre of the aortic arch branches, the percentage of stenosis alone cannot be considered an accurate measure of the severity of the stenosis, and hence a reliable criterion of choice of the treatment.

Published
2002

150. Disulfiram, an old drug with new potential therapeutic uses for human hematological malignancies

Author

Conticello, C, Martinetti, D, Adamo, L, Buccheri, S, Giuffrida, R, Parrinello, N, Lombardo, L, Anastasi, Giulia, Amato, G, Cavalli, M, Chiarenza, A, De Maria Marchiano, Ruggero, Giustolisi, R, Gulisano, Mario Domenico, Di Raimondo, F., Anastasi G, De Maria Marchiano R (ORCID:0000-0003-2255-0583), Gulisano M, Conticello, C, Martinetti, D, Adamo, L, Buccheri, S, Giuffrida, R, Parrinello, N, Lombardo, L, Anastasi, Giulia, Amato, G, Cavalli, M, Chiarenza, A, De Maria Marchiano, Ruggero, Giustolisi, R, Gulisano, Mario Domenico, Di Raimondo, F., Anastasi G, De Maria Marchiano R (ORCID:0000-0003-2255-0583), and Gulisano M

Abstract

Disulfiram (DSF) is an aldehyde dehydrogenase inhibitor currently used for the treatment of alcoholism. Here, we show that multiple myeloma (MM) cell lines and primary cells from newly diagnosed and relapsed/resistant patients affected by MM, acute myeloid and lymphoblastic leukemia are significantly sensitive to DSF alone and in combination with copper. These effects are present at doses lower than those achievable in vivo after DSF standard administration. The cytotoxic effect achieved by this treatment is comparable to that obtained by conventional chemotherapy and is absent in normal hematopoietic cells. In addition, we found that DSF plus copper induces loss of mitochondrial membrane potential, triggers reactive oxygen species (ROS) production and activates executioner caspases. DSF-copper-induced apoptosis and caspases activation are strongly reversed by antioxidant N-acetylcysteine, thus indicating a critical role of ROS. These results might suggest the use of the old drug DSF, alone or in combination with copper, in the treatment of hematological malignancies.

Published
2012

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