101. APOE, CETP and LPL genes show strong association with lipid levels in Greek children
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George Dedoussis, Nikolas Maniatis, Constantina Papoutsakis, Fotios Drenos, Melissa C. Smart, Eirini Louizou, Mary Yannakoulia, Philippa J. Talmud, and Steve E. Humphries
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Apolipoprotein E ,Male ,Genetic variants ,Apolipoprotein B ,PC2, second principal component ,Endocrinology, Diabetes and Metabolism ,BMI, body mass index ,Statistics as Topic ,Blood lipids ,Medicine (miscellaneous) ,Body Mass Index ,HDL-C, high-density lipoprotein cholesterol ,Cohort Studies ,chemistry.chemical_compound ,High-density lipoprotein ,NS, not statistically significant ,Child ,IQR, inter quartile range ,Genetics ,Nutrition and Dietetics ,biology ,medicine.diagnostic_test ,TG, triglyceride ,Greece ,Homozygote ,PC1, first principal component ,CETP, cholesterol ester transfer protein ,Lipids ,TGRL, triglyceride rich lipoproteins ,LPL, lipoprotein lipase ,Cholesterol ,Low-density lipoprotein ,SNPs, single nucleotide polymorphisms ,Female ,lipids (amino acids, peptides, and proteins) ,Cardiology and Cardiovascular Medicine ,medicine.medical_specialty ,Heterozygote ,Hypercholesterolemia ,T2D, type 2 diabetes ,MAF, minor allele frequency ,Polymorphism, Single Nucleotide ,Article ,Apolipoproteins E ,Internal medicine ,medicine ,Humans ,Obesity ,AA, amino acid ,Apolipoproteins A ,Genetic Association Studies ,PCA, principal component analysis ,Apolipoprotein C-III ,HWE, Hardy–Weinberg equilibrium ,Cholesterol, HDL ,GENDAI, Gene–Diet Attica Investigation on childhood obesity ,Cholesterol, LDL ,Single nucleotide polymorphisms ,GWAS, genome wide association studies ,Cholesterol Ester Transfer Proteins ,TC, total cholesterol ,Lipoprotein Lipase ,Endocrinology ,Apolipoproteins ,chemistry ,CI, confidence intervals ,biology.protein ,LDL-C, low-density lipoprotein cholesterol ,APO, apolipoprotein ,Lipid profile ,Lipoprotein - Abstract
Background and aims Studies have consistently demonstrated that variants in a number of candidate genes are significant determinants of lipid levels in adults. However, few studies have investigated the impact of these variants in children. Therefore, in the present investigation we examined the influence of ten common variants in the genes for lipoprotein lipase (LPL – S447X), cholesterol ester transfer protein (CETP – Taq1B) apolipoprotein (APO) E (ɛ2, ɛ3, ɛ4), APOA5 (−1131C > T and S19W), APOA4 (S347T) and APOC3 (−482C > T; 1100C > T and 3238G > C) on lipoprotein levels children from the Gene–Diet Attica Investigation on childhood obesity (GENDAI). Methods and results The ten variants selected were genotyped in 882 Greek children, mean age: 11.2 ± 0.7 years (418 females and 464 males). Genotypes were assessed using TaqMan technology. Significantly higher total cholesterol (TC) (p = 0.0001) and low-density lipoprotein cholesterol (LDL-C) (p
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