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Children have many opportunities to learn from others through oral and written sources. Recent evidence suggests that early readers place more trust in written over oral testimony when learning names for unfamiliar objects. Across three studies, we examined whether the authority of print extends beyond mere naming to guide children's actions in the physical world. In Study 1, 3- to 6-year-olds received conflicting oral and print-based advice from two puppets about how to operate a novel apparatus. Whereas pre-readers were indiscriminate in their trust, early readers preferred to follow the print-based advice. In Study 2, we replicated this finding, controlling for the amount of corroborating evidence presented by both sources, and the location of the print. In Study 3, we explored whether readers' preference for print-based information was due to a global preference for external representations, or a more specific preference for text. Children were presented with conflicting instructions based on text versus a coloured circle. Whereas pre-readers preferred to follow the colour circle, readers preferred to follow the text. Together, the results suggest that when children learn to read, they rapidly come to regard the written word as a particularly authoritative source of information about how to act in the world., (© 2014 The British Psychological Society.)

The present research investigates how young children evaluate and reason about the disclosure of private information. Using story vignettes, children aged 4-5 and 7-8 years were asked to evaluate an individual who passed on information from a peer revealing that he or she had broken a rule (e.g., stolen a cookie; rule type) or lacked a skill (e.g., could not ride a bicycle; competence type). These negative valence stories were compared with positive valence stories in which the peer had followed a rule or possessed a skill. Younger children approved the sharing of positive, but not negative, information, irrespective of type (rule vs. competence). Older children disapproved the disclosure of someone's incompetence, whereas they approved the disclosure of a rule violation. Children justified their evaluations by reference to social rules in the rule-type vignettes and to an individual's feelings in the competence-type vignettes. The findings suggest that young children are concerned about the disclosure of negative information about other people, but with age they become increasingly concerned about protecting the social order even at the cost of individual privacy., (© 2014 The British Psychological Society.)

Children's affective experiences and cognitive abilities have an impact on emotion understanding. However, their relative contribution, as well as the possibility of an interaction between them, has rarely been examined. The aim of the present study was to evaluate the influence of severe abuse and learning difficulties on simple and complex components of emotion understanding in late childhood and early adolescence. A total of 28 older children and young adolescents were selected for the study. Half of the participants had suffered from severe abuse, and half of these abused children additionally had learning disabilities. The remaining half of the sample had no history of abuse but were matched with the abused children on learning difficulties, age and gender. The participants' emotion understanding was assessed with the Test of Emotion Comprehension (TEC). Results showed that (a) learning difficulties but not abuse had an impact on emotion understanding, (b) there was no interaction effect of abuse and learning difficulties on emotion understanding, and (b) the observed effects of learning difficulties were most apparent for the understanding of relatively complex components of emotion and not for simple components. The results are discussed in terms of their theoretical and practical implications.

Understanding the context for children's social learning and language acquisition requires consideration of caregivers' multi-modal (speech, gesture) messages. Though young children can interpret both manual and head gestures, little research has examined the communicative input that children receive via parents' head gestures. We longitudinally examined the frequency and communicative functions of mothers' head nodding and head shaking gestures during laboratory play sessions for 32 mother-child dyads, when the children were 14, 20, and 30 months of age. The majority of mothers produced head nods more frequently than head shakes. Both gestures contributed to mothers' verbal attempts at behavior regulation and dialog. Mothers' head nods primarily conveyed agreement with, and attentiveness to, children's utterances, and accompanied affirmative statements and yes/no questions. Mothers' head shakes primarily conveyed prohibitions and statements with negations. Changes over time appeared to reflect corresponding developmental changes in social and communicative dimensions of caregiver-child interaction. Directions for future research are discussed regarding the role of head gesture input in socialization and in supporting language development., (Copyright © 2014 Elsevier Inc. All rights reserved.)

Children and adults differentiate statements of religious belief from statements of fact and opinion, but the basis of that differentiation remains unclear. Across three experiments, adults and 8-10-year-old children heard statements of factual, opinion-based, and religious belief. Adults and children judged that statements of factual belief revealed more about the world, statements of opinion revealed more about individuals, and statements of religious belief provided information about both. Children-unlike adults-judged that statements of religious belief revealed more about the world than the believer. These results led to three conclusions. First, judgments concerning the relative amount of information statements of religious belief provide about individuals change across development, perhaps because adults have more experience with diversity. Second, recognizing that statements of religious belief provide information about both the world and the believer does not require protracted learning. Third, statements of religious belief are interpreted as amalgams of factual and opinion-based statements.

Children and adults often encounter counterintuitive claims that defy their perceptions. We examined factors that influence children's acceptance of such claims. Children ages 3-6 years were shown familiar objects (e.g., a rock), were asked to identify the objects, and were then told that each object was something else (e.g., that the rock was soap). For some children, informants explicitly stated that the objects were different from what they appeared to be, whereas other children received testimony about the objects' identities without any reference to the discrepancy between appearance and reality. Children also completed standard tasks measuring appearance-reality understanding. When later asked about the objects' identities and properties, children who had a firm understanding of the appearance-reality distinction and those who heard informants mention that distinction were more accepting of the informants' counterintuitive claims. Thus, receptivity to counterintuitive claims can reflect conceptual growth rather than simple deference or conformity., (PsycINFO Database Record (c) 2014 APA, all rights reserved.)

Preschool children were presented with slides on a computer screen showing a novel object, together with two informants, one with an attractive and one with a less attractive face. Children were asked which informant they would like to ask about the name of the novel object. After hearing the informants provide conflicting names, they were asked who they thought was correct. Children were more likely to endorse names provided by the person with the more attractive face, a bias that cannot be justified on epistemic grounds. The implications of this finding are discussed., (© 2013 The British Psychological Society.)

Recent research shows that even preschoolers are skeptical; they frequently reject claims from other people when the claims conflict with their own perceptions and concepts. Yet, despite their skepticism, both children and adults come to believe in a variety of phenomena that defy their first-hand perceptions and intuitive conceptions of the world. In this review, we explore how children and adults acquire such concepts. We describe how a similar developmental process underlies mental representation of both the natural and the supernatural world, and we detail this process for two prominent supernatural counterintuitive ideas-God and the afterlife. In doing so, we highlight the fact that conceptual development does not always move in the direction of greater empirical truth, as described within naturalistic domains. We consider factors that likely help overcome skepticism and, in doing so, promote belief in counterintuitive phenomena. These factors include qualities of the learners, aspects of the context, qualities of the informants, and qualities of the information., (© The Author(s) 2014.)

As children listen to a simple action-based narrative, they construct a dynamic representation of the protagonist's movements, visual perspective, and goal-directed thoughts. We examined children's representations of more complex narratives in which the protagonist will encounter an unexpected outcome upon reaching his or her goal. Three studies involving 105 children between 3 and 6 years of age showed that children shifted in the mental states they attributed depending on the distance of the protagonist from the unexpected outcome. Even though children consistently recognized that the protagonist did not know about the surprise at any point, they increasingly attributed feelings and thoughts consistent with the surprise. The studies highlight the degree to which children's mental state attributions are dynamic rather than fixed by their current theory of mind., (PsycINFO Database Record (c) 2014 APA, all rights reserved.)

What kinds of cues increase imitative fidelity in early childhood? The effects of multiple models and verbal framing were examined in preschool children (N = 259, 3-6-year-olds). Each participant was presented with one of eight possible combinations of type of modeling and verbal frame. The type of modeling involved: (i) a single model offering two demonstrations, (ii) two successive models each offering a single demonstration, (iii) two synchronous models each offering two demonstrations, or (iv) two synchronous models each offering a single demonstration. The verbal frame preceding the demonstrations emphasized either the instrumental outcome of the actions or their conventionality. Imitative fidelity was highest for the synchronous models (types iii and iv) and lowest for the single model (type i). Imitative fidelity was also higher for the convention-oriented than the outcome-oriented frame and higher for older than younger children. Children also provided more conventional explanations for their actions after viewing the synchronous models and after the convention-oriented framing. The results indicate that children's imitative fidelity depends on the number of actors and the way the actions are framed., (Copyright © 2013 Elsevier B.V. All rights reserved.)

This study employed the selective trust paradigm to examine how children interpret novel labels when compared with labels they already know to be accurate or inaccurate within the biological domain. The participants--3-, 4-, and 5-year-olds (N=144)--were allocated to one of three conditions. In the accurate versus inaccurate condition, one informant labeled body parts correctly, whereas the other labeled them incorrectly (e.g., calling an eye an "arm"). In the accurate versus novel condition, one informant labeled body parts accurately, whereas the other provided novel labels (e.g., calling an eye a "roke"). Finally, in the inaccurate versus novel condition, one informant labeled body parts incorrectly, whereas the other offered novel labels. In subsequent test trials, the two informants provided conflicting labels for unfamiliar internal organs. In the accurate versus inaccurate condition, children sought and endorsed labels from the accurate informant. In the accurate versus novel condition, only 4- and 5-year-olds preferred the accurate informant, whereas 3-year-olds did not selectively prefer either informant. In the inaccurate versus novel condition, only 5-year-olds preferred the novel informant, whereas 3- and 4-year-olds did not demonstrate a selective preference. Results are supportive of previous studies suggesting that 3-year-olds are sensitive to inaccuracy and that 4-year-olds privilege accuracy. However, 3- and 4-year-olds appear to be unsure as to how the novel informant should be construed. In contrast, 5-year-olds appreciate that speakers offering new information are more trustworthy than those offering inaccurate information, but they are cautious in judging such informants as being "better" at providing that information., (Copyright © 2013 Elsevier Inc. All rights reserved.)

[This corrects the article DOI: 10.1371/journal.pone.0059510.].

Lipid peroxidation generates reactive aldehydes, most notably hydroxynonenal (HNE), which covalently binds amino acid residue side chains leading to protein inactivation and insolubility. Specific adducts of lipid peroxidation have been demonstrated to be intimately associated with pathological lesions of Alzheimer's disease (AD), suggesting that oxidative stress is a major component in the disease. Here, we examined the HNE-cross-linking modifications by using an antibody specific for a lysine-lysine cross-link. Since in a prior study we noted no immunolabeling of neuritic plaques or neurofibrillary tangles but instead found strong labeling of axons, we focused this study on axons. Axonal labeling was examined in mouse sciatic nerve, and immunoblotting showed the cross-link was restricted to neurofilament heavy and medium subunits, which while altering migration, did not indicate larger NF aggregates, indicative of intermolecular cross-links. Examination of mice at various ages showed the extent of modification remaining relatively constant through the life span. These findings demonstrate lipid-cross-linking peroxidation primarily involves lysine-rich neurofilaments and is restricted to intramolecular cross-links.

The beliefs people hold about the social and physical world are central to self-definition and social interaction. The current research analyzes reasoning about three kinds of beliefs: those that concern matters of fact (e.g., dinosaurs are extinct), preference (e.g., green is the prettiest color), and ideology (e.g., there is only one God). The domain of ideology is of unique interest because it is hypothesized to contain elements of both facts and preferences. If adults' distinct reasoning about ideological beliefs is the result of prolonged experience with the physical and social world, children and adults should reveal distinct patterns of differentiating kinds of beliefs, and this difference should be particularly pronounced with respect to ideological beliefs. On the other hand, if adults' reasoning about beliefs is a basic component of social cognition, children and adults should demonstrate similar belief representations and patterns of belief differentiation. Two experiments demonstrate that 5-10 year old children and adults similarly judged religious beliefs to be intermediate between factual beliefs (where two disagreeing people cannot both be right) and preferences (where they can). From the age of 5 years and continuing into adulthood, individuals distinguished ideological beliefs from other types of mental states and demonstrated limited tolerance for belief-based disagreements.

Past research provides evidence that children use at least 2 potentially competing strategies when choosing informants: they attend to informants' past accuracy and to their social identity (e.g., their status as native- vs. foreign-accented speakers). We explore how children reconcile these 2 strategies when they are put in conflict and whether children's response changes across development. In Experiment 1 (N = 61), 3-, 4-, and 5-year-old children watched a native- and a foreign-accented English speaker label novel objects with novel names. All 3 age groups preferred the names provided by the native speaker. Next, 1 of the 2 speakers named familiar objects accurately, whereas the other speaker named them inaccurately. In a subsequent series of test trials, again with novel objects, 4- and 5-year-olds, but not 3-year-olds, were likely to endorse the names provided by the accurate speaker, regardless of her accent. In Experiment 2 (N = 72) 4-year-olds first watched a native- and a foreign-accented speaker name familiar objects, but the relative accuracy of the 2 speakers varied across conditions (100% vs. 0% correct; 75% vs. 25% correct). Subsequently, the 2 speakers provided novel names for novel objects. In each condition, 4-year-olds endorsed the names provided by the more accurate speaker, regardless of her accent. We propose that during the preschool years, children increasingly rely on past reliability when selecting informants.

Children ages 18 and 24 months were assessed for the ability to understand and learn from an adult's nonverbal expression of agreement and disagreement with a speaker's claims. In one type of communicative exchange, a speaker made 2 different claims about the identity or location of an object. The hearer nodded her head in agreement with one claim and shook her head in disagreement with the other claim. In a second type of exchange, the speaker asked 2 different questions about the identity or location of an object. The hearer nodded her head in response to one question and shook her head in response to the other. The 24-month-olds grasped the implication of these gestural responses, by inferring the correct name or location of the object. The 18-month-olds showed a limited grasp of their implications. Thus, in learning from others' testimony, toddlers focus not only on the claims of a single speaker but also on whether that information is accepted or rejected by another hearer. In particular, they detect and act on social cues of assent and dissent.

Young children endorse fairness norms related to sharing, but often act in contradiction to those norms when given a chance to share. This phenomenon has rarely been explored in the context of a single study. Using a novel approach, the research presented here offers clear evidence of this discrepancy and goes on to examine possible explanations for its diminution with age. In Study 1, 3-8-year-old children readily stated that they themselves should share equally, asserted that others should as well, and predicted that others had shared equally with them. Nevertheless, children failed to engage in equal sharing until ages 7-8. In Study 2, 7-8-year-olds correctly predicted that they would share equally, and 3-6-year-olds correctly predicted that they would favor themselves, ruling out a failure-of-willpower explanation for younger children's behavior. Similarly, a test of inhibitory control in Study 1 also failed to explain the shift with age toward adherence to the endorsed norm. The data suggest that, although 3-year-olds know the norm of equal sharing, the weight that children attach to this norm increases with age when sharing involves a cost to the self.

Recent research has shown that by 30 months of age, children can successfully update their representation of an absent object's location on the basis of new verbal information, whereas 23-month-olds often return to the object's prior location. The current results show that this updating failure persisted even when (a) toddlers received visual and verbal information about the prior location but no motor information, or (b) toddlers received only visual information about the prior location, or (c) toddlers received only verbal information about the prior location, and (d) whether or not the prior location was mentioned at the time they received the new verbal information. The results are explained in terms of working memory limitations on children's ability to use language when the new information conflicts with existing information., (Copyright © 2012 Elsevier Inc. All rights reserved.)

Children prefer to learn from informants in consensus with one another. However, no research has examined whether this preference exists across cultures, and whether the race of the informants impacts that preference. In 2 studies, one hundred thirty-six 4- to 7-year-old European American and Taiwanese children demonstrated a systematic preference for a consensus. Nevertheless, the initial strength and persistence of that preference depended on the racial composition of the consensus. Children's preference for consensus members belonging to the same race as themselves persisted even when only one consensus member remained to provide information. When the consensus consisted of different-race informants, preference for the consensus was initially apparent but lost when only one member from the consensus remained with the dissenting informant., (© 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.)

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen in hospital-acquired infections. MRSA-colonized inpatients who may benefit from undergoing decolonization have not been identified., Objective: To identify risk factors for MRSA infection among patients who are colonized with MRSA at hospital admission., Design: A case-control study., Setting: A 146-bed Veterans Affairs hospital., Participants: Case patients were those patients admitted from January 2003 to August 2011 who were found to be colonized with MRSA on admission and then developed MRSA infection. Control subjects were those patients admitted during the same period who were found to be colonized with MRSA on admission but who did not develop MRSA infection., Methods: A retrospective review., Results: A total of 75 case patients and 150 control subjects were identified. A stay in the intensive care unit (ICU) was the significant risk factor in univariate analysis (P<.001). Prior history of MRSA (P=.03), transfer from a nursing home (P=.002), experiencing respiratory failure (P<.001), and receipt of transfusion (P=.001) remained significant variables in multivariate analysis. Prior history of MRSA colonization or infection (P=.02]), difficulty swallowing (P=.04), presence of an open wound (P=.02), and placement of a central line (P=.02) were identified as risk factors for developing MRSA infection for patients in the ICU. Duration of hospitalization, readmission rate, and mortality rate were significantly higher in case patients than in control subjects (P < .001, .001, and <.001, respectively)., Conclusions: MRSA-colonized patients admitted to the ICU or admitted from nursing homes have a high risk of developing MRSA infection. These patients may benefit from undergoing decolonization.

Children can identify owners either by seeing a person in possession of an object (a visual cue) and inferring that they are the owner or by hearing testimony about a claim of ownership (a verbal cue). A total of 391 children between 2.5 and 6 years of age were tested in three experiments assessing how children identify owners when these two cues are in conflict. Children were presented with stories using two dolls and a toy. One doll possessed the toy, and children were told that the toy was either the possessor's or the nonpossessor's. Two forms of ownership statement were used: a third-person statement, "That is Billy's ball", and a first-person statement by one of the dolls, "That is my ball". The results show that by 4 years of age, children prioritize the verbal statements as a more reliable cue to ownership than physical possession. Younger children did not prioritize possession over the verbal cue to ownership but rather gave mixed responses. These results are discussed in terms of children's social experience outside of the home and their acceptance of testimony in other domains., (Copyright © 2012 Elsevier Inc. All rights reserved.)

Although often conceptualized in contradictory terms, the common assumption that natural and supernatural explanations are incompatible is psychologically inaccurate. Instead, there is considerable evidence that the same individuals use both natural and supernatural explanations to interpret the very same events and that there are multiple ways in which both kinds of explanations coexist in individual minds. Converging developmental research from diverse cultural contexts in 3 areas of biological thought (i.e., the origin of species, illness, and death) is reviewed to support this claim. Contrary to traditional accounts of cognitive development, new evidence indicates that supernatural explanations often increase rather than decrease with age and supports the proposal that reasoning about supernatural phenomena is an integral and enduring aspect of human cognition., (© 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.)

Spinal cord ischemia (SCI) is a catastrophic complication of thoracoabdominal aortic aneurysm (TAAA) repair. This article describes our early experience with a technique for maintaining perfusion of segmental vessels (intercostals and lumbars) in the early postoperative period after endovascular repair of a TAAA, with "sac perfusion branches" added to custom-made stent grafts. These are closed 7 to 10 days after the first procedure to complete exclusion of the aneurysm. We have used this technique in 10 patients with type II TAAAs. One developed monoparesis of the right leg during a period of hypotension secondary to a cardiac event and died within 30 days. Two patients developed lower limb weakness after closure of the perfusion branches, both with full recovery. Controlled perfusion of segmental vessels with perfusion branches is feasible and may be a useful adjunct to prevent SCI, providing protection to spinal cord perfusion during the immediate postoperative period when risk of SCI is greatest., (Crown Copyright © 2012. Published by Mosby, Inc. All rights reserved.)

Introduction: Renal artery dissection is a rare cause of abdominal pain. The renal arteries are the commonest site of primary dissection involving visceral vessels but spontaneous bilateral dissection is extremely rare., Presentation of Case: We present a case of spontaneous bilateral renal artery dissection in a previously fit 43-year-old man who presented with right iliac fossa pain. He was treated conservatively with anticoagulation for 6 months, with resolution of the dissections on imaging at 6-month follow-up., Discussion: The presentation of spontaneous renal artery dissection is non-specific, making it a diagnostic challenge. Computed Tomography angiography is now the gold standard for diagnosis and follow-up of these patients., Conclusion: This case highlights the importance of considering other causes of abdominal pain in a young man with normal initial investigations and the role of conservative management., (Copyright © 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.)

The treatment of chronic type B aortic dissections remains challenging and controversial. Currently most centers advocate open or endovascular intervention for patients with evidence of malperfusion, rupture or impending rupture, continued pain, or aneurysm formation. Regardless of the type of intervention, the incidence of complications or death remains high, even when undertaken in an elective setting. The standard endovascular treatment usually involves placement of a stent graft into the true lumen of the dissection in an effort to exclude the false lumen. This case report describes the placement of a branched stent graft into the false lumen of a patient with chronic type B dissection to encourage exclusion and thrombosis of the true lumen whilst maintaining flow to all visceral vessels., (Copyright © 2011 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.)

Much recent evidence shows that preschoolers are sensitive to the accuracy of an informant. Faced with two informants, one of whom names familiar objects accurately and the other inaccurately, preschoolers subsequently prefer to learn the names and functions of unfamiliar objects from the more accurate informant. This study examined the inference process underlying this preference. We asked whether preschoolers make narrow inferences about informants, broader trait-based inferences, or more global evaluative inferences. We further asked what inferences preschoolers make about a potential informant based on distinctions in the unrelated domain of physical strength. The results indicate that preschoolers make relatively narrow inferences when observing individual differences in accuracy even though they are prone to global evaluative inferences when observing individual differences in strength. Preschoolers' burgeoning understanding of others as expert language users may underlie their selective endorsement of a more accurate informant., (Copyright © 2011 Elsevier Inc. All rights reserved.)

The phosphorylated ribosomal protein S6 (pS6) is associated with the 40S ribosomal subunit in eukaryotes and is thought to have a role in RNA storage, degradation, and re-entry into translation. In this study, we found pS6 localized to granulovacuolar degeneration (GVD) within the pyramidal neurons. Immunohistochemical analysis found that nearly 20-fold more neurons contain pS6-positive granules in Alzheimer's disease (AD) hippocampus compared with age-matched controls. Further, pS6-positive granules were more common in neurons not containing neurofibrillary tangles (NFTs), were never associated with extracellular NFTs or in apoptotic neurons, and contained less RNA than neighboring pyramidal neurons not containing pS6-positive granules. In model systems, pS6 is a specific marker for stress granules, and another stress granule protein, p54/Rck, was also found to be a component of GVD in the current study. Stress granules are transient, intracellular, dense aggregations of proteins and RNAs that accumulate as a stress response, protecting cells from apoptosis and inappropriate transcriptional activity, often described as a form of 'molecular triage.' The RNA oxidation modification 8-hydroxyguanosine (8OHG) is strikingly increased in AD, yet this study reports that those neurons with pS6 granules display reduced RNA oxidation demonstrated by lower levels of 8OHG. Since chronic oxidative stress is central to AD pathogenesis, and RNA is a specific oxidative stress target and is intimately associated with stress granule biogenesis in model systems, we suggest that GVD in human brain parallel stress granules, and may in fact be more representative of early disease pathogenesis than traditionally believed. This proposed origin for GVD as a neuroprotective response, may represent a morphologic checkpoint between cell death and reversible cellular stress that proceeds in the absence of other inclusions.

Objective: The outcomes for patients after endovascular treatment of abdominal aortic aneurysm (AAA) are determined primarily by the endpoints of death and endoleaks, the latter representing continued risk of rupture. The data of a multicentre registry were analysed with regard to the early outcome of stent-graft procedures for AAA and the complications associated with this treatment. In addition, the results during follow-up were analysed by determining mortality and endoleak development as separate endpoints and as a combined endpoint defined as endoleak-free survival., Setting: 38 European institutions of Vascular Surgery collaborating in a multicentre registry project., Patients and Methods: 899 patients with AAA underwent between May 1994 and March 1998 elective endovascular repair (818 men and 81 women; mean age 69 years). 80 (8.9%) of the patients had medical conditions that excluded them from open repair. 818 (91%) of patients had a bifurcated device, 63 (7%) had a straight tube graft, and only 18 (2%) had an aorto-uni-iliac device. Clinical examination and contrast-enhanced computed tomography was performed at fixed follow-up intervals to assess increase or decrease of the maximum transverse diameter (MTD). Endoleaks observed at follow-up were discriminated into persistent endoleak and temporary endoleak. The latter is defined as single time observed endoleaks or with two or more negative imaging studies between observed endoleaks. Life-table analyses were used to calculate the rates of freedom-from-endoleak (no endoleak at any time), freedom-from-persistent endoleak (no persistent endoleak), patient survival, and persistent-endoleak-free-survival., Results: The median follow-up of this patient series was 6.2 months. The ratio between observed and expected follow-up data was 82% for the overall follow-up period. However, at 18 months of follow-up this rate was only 45%. The number of patients followed during this period was sufficient to allow statistically meaningful assessment. The MTD in patients with temporary endoleaks demonstrated a significant decrease at 6 to 12 months compared to preoperative values (mean 57 and 53 respectively, p = 0.004). In patients with persistent endoleaks there was no change between the preoperative and 6-month MTD (mean 57 and 60 mm respectively). At 6 and 18 months freedom-from-endoleak was 83% and 74% and freedom-from-persistent endoleak was 93% and 90%, respectively. The 18-month cumulative patient survival was 88% and the main outcome measure, the persistent endoleak-free-survival was 79%., Conclusions: The MTD decreases in patients with temporary endoleak, but not in patients with persistent endoleak. Therefore, the use of the rate of freedom-from-persistent endoleak, reflecting absence of persisting endoleaks to estimate the prognosis with regard to the AAA, is justified. Determining persistent endoleak-free survival appears a rational approach to provide a realistic outlook for patients with stent-grafted AAA. The observed 18-month endoleak-free survival reflects a satisfactory mid-term result., (Copyright © 2011. Published by Elsevier Ltd.)

Young children seem to operate under the assumption that objects always fall in a straight vertical line. When asked to search for a ball dropped down an S-shaped opaque tube, they repeatedly search directly below. Hood proposed that children have difficulty in inhibiting their prepotent expectation that objects fall in a straight line (Hood, 1995). We asked whether the inability to inhibit this prepotent response is the only factor determining children's performance on the tubes task. In one condition the openings to the tubes were covered by chimneys, whereas in another condition the openings were visible. When first tested with the apparatus, children performed better when the openings were visible. Furthermore, children's performance on equally complex configurations (i.e., with or without chimneys) was modulated by their previous experience. Thus, children's understanding of the tubes mechanism seems to play an important role in addition to inhibitory control., (Copyright © 2011 Elsevier Inc. All rights reserved.)

To navigate a world filled with private property, children must be able to assign ownership information to objects and update that information when appropriate. In this chapter, the authors propose that children include ownership as an attribute of their object representations. Children can learn about ownership attributes either by witnessing owners acting on their property, a visual source, or by receiving information from the testimony of others, a verbal source. The authors consider the differences between these two forms of information and how they might conflict at the representational level, leading to difficulties in learning about ownership., (Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company.)

Young children readily act on information from adults, setting aside their own prior convictions and even continuing to trust informants who make claims that are manifestly false. Such credulity is consistent with a long-standing philosophical and scientific conception of young children as prone to indiscriminate trust. Against this conception, we argue that children trust some informants more than others. In particular, they use two major heuristics. First, they keep track of the history of potential informants. Faced with conflicting claims, they endorse claims made by someone who has provided reliable care or reliable information in the past. Second, they monitor the cultural standing of potential informants. Faced with conflicting claims, children endorse claims made by someone who belongs to a consensus and whose behaviour abides by, rather than deviating from, the norms of their group. The first heuristic is likely to promote receptivity to information offered by familiar caregivers, whereas the second heuristic is likely to promote a broader receptivity to informants from the same culture.

Prolonged endovascular procedures requiring a large diameter sheath in each groin can be associated with significant intraoperative lower limb ischemia, particularly in those with pre-existing peripheral vascular disease. We report the case of a patient who suffered severe ischemia-reperfusion injury following endovascular repair of a pararenal aortic aneurysm using a fenestrated stent graft and describe the use of temporary axillobifemoral bypass in a patient with similar comorbidities undergoing the same procedure. We propose this adjunctive technique as a means of maintaining antegrade limb perfusion and avoiding the peripheral and central metabolic consequences of ischemia-reperfusion injury., (Copyright © 2011 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.)

Across three studies, we investigated whether 4-year-olds would trust a previously reliable informant when learning novel morphological forms. In Experiment 1, children (N= 16) were presented with two informants: one who correctly named familiar objects and another who named them incorrectly. Children were invited to turn to these informants when learning novel labels and morphological forms. The majority of children chose the previously correct labeller when learning novel label and morphology. In Experiment 2, children (N= 16) were presented with an informant who used familiar plurals correctly and one who used them incorrectly. Children chose the previously correct morphologist when learning novel labels and past tense forms. Thus, children track both semantic and morphological accuracy. In Experiment 3, some children (N= 16) were presented with two informants who differed in naming accuracy, whereas others (N= 16) were presented with two informants who differed in morphological accuracy. To forestall any risk of experimenter cuing, one experimenter blind to the training children had received, tested children with novel labels and morphology. The results replicated those of Experiments 1 and 2. Implications for how children's trust in an informant might play a role in their acquisition of morphological forms are discussed., (©2010 The British Psychological Society.)

Purpose: To review the early outcome following endovascular repair of pararenal aortic aneurysm using fenestrated stent-grafts and to determine if the number of fenestrations required is predicative of outcome., Methods: A retrospective analysis was conducted of 20 consecutive patients (18 men; mean age of 75 ± 7 years) treated with stent-grafts containing either ≤ 2 fenestrations (n = 10, group 1) or 3 fenestrations (n = 10, group 2). Target vessels also included those accommodated by a scallop (renal artery or superior mesenteric artery in group 1 and the celiac artery in group 2)., Results: Comorbidities were similar in both groups. Aneurysm size [median 6.9 (IQR 6.7-8.3) versus 6.0 cm (IQR 5.8-6.6), p = 0.03], procedure time (mean 6.6 ± 2.1 versus 4.6 ± 1.7 hours, p = 0.04), and intensive care stay [median 4.5 (IQR 2-14) versus 2 (IQR 1-3) days, p = 0.07] were greater in group 2. There were 2 postoperative deaths, both in group 2. Morbidity was significant and similar in both groups (4 patients in group 1 and 3 patients in group 2), including 1 patient requiring long-term hemodialysis. Target vessel preservation was similar in both groups (96% overall). There were 2 type II endoleaks (one in each group) and no type I or III endoleak., Conclusion: Triple-fenestrated stent-grafts allow patients with extensive pararenal aneurysms and significant comorbidity to be treated by endovascular means. Although the number of patients treated was small, which limited the validity of the comparison, longer procedures and greater early morbidity and mortality were seen in the triple-fenestrated group. At present, the procedures are technically more demanding and associated with increased risk compared with double or single fenestrations, but the technology continues to evolve.

Across two experiments, preschool-aged children demonstrated selective learning of non-linguistic information from native-accented rather than foreign-accented speakers. In Experiment 1, children saw videos of a native- and a foreign-accented speaker of English who each spoke for 10 seconds, and then silently demonstrated different functions with novel objects. Children selectively endorsed the silent object function provided by the native-accented speaker. In Experiment 2, children again endorsed the native-accented over the foreign-accented speaker, even though both informants previously spoke only in nonsense speech. Thus, young children demonstrate selective trust in native-accented speakers even when neither informant's speech relays meaningful semantic content, and the information that both informants provide is non-linguistic. We propose that children orient towards members of their native community to guide their early cultural learning., (© 2010 Blackwell Publishing Ltd.)

CD3ζ is a subunit of the CD3 molecule that, until recently, appeared restricted to T cells and natural killer cells. However, experimental studies have demonstrated a role of CD3ζ in dendritic outgrowth in the visual system as well as in synaptic plasticity. Given the increasing evidence for uncharacteristic recapitulation of neurodevelopmental processes in neurodegenerative diseases, in this study, we evaluated brains from subjects with Parkinson's disease and Lewy body dementia for evidence of aberrant CD3 expression. Our data shows marked CD3ζ in association with the α-synuclein containing pathological lesions, i.e., Lewy bodies and Lewy neurites, in the brains of subjects with Parkinson's disease and Lewy body dementia. This finding raises the novel concept of CD3 dysregulation in these disorders as a pathogenic factor and also furthers the increasing evidence that the recall of aberrant neurodevelopmental processes underlies the pathogenesis of neurodegenerative diseases.

Previous research suggests that children gradually understand the mitigating effects of apology on damage to a transgressor's reputation. However, little is known about young children's insights into the central emotional implications of apology. In two studies, children ages 4-9 heard stories about moral transgressions in which the wrongdoers either did or did not apologize. In Study 1, children in the no-apology condition showed the classic pattern of 'happy victimizer' attributions by expecting the wrongdoer to feel good about gains won via transgression. By contrast, in the apology condition, children attributed negative feelings to the transgressor and improved feelings to the victim. In Study 2, these effects were found even when the explicit emotion marker 'sorry' was removed from the apology exchange. Thus, young children understand some important emotional functions of apology.

Background: Hurricane Katrina devastated the Mississippi Gulf Coast in August 2005. Intrusive re-experiencing is a common posttraumatic stress symptom. However, young children with limited introspection skills might have difficulties identifying their intrusive thoughts., Method: A sample of 165 5- to 9-year-old children were surveyed about their unwanted intrusive thoughts and their knowledge about thinking, 10 months following the hurricane., Results: Results replicate and extend the findings from a previous study (Sprung, 2008). Although there was no difference in the overall occurrence of intrusive thoughts, there was a striking difference between hurricane-exposed and control children in their contents. Children's knowledge about thinking was linked to their ability to report on their negative intrusive thoughts, even taking language ability into account., Conclusion: There is a shift toward negative content following hurricane exposure compared with non-hurricane-exposed children and knowledge about thinking is linked to the reporting of such intrusive thoughts. Implications for current research on autobiographical memory and for interventions following potentially traumatic events are discussed., (© 2010 The Authors. Journal compilation © 2010 Association for Child and Adolescent Mental Health.)

Purpose: To describe a novel technique for target vessel catheterization in patients with juxtarenal abdominal aortic aneurysms requiring treatment with fenestrated stent-grafts (FSG)., Methods: The standard FSG design was modified, substituting a thin-wall tube for the solid central obturator that serves as both an attachment point for the distal end of the graft as well as a top cap retriever. Through this tube, two 0.020-inch wires are run from the hub of the delivery system through the stent-graft, out through each fenestration, and up to the proximal edge of the graft, where they are attached by sutures. The sutures are connected to a trigger wire on the control hub. The preloaded wires facilitate passage of a sheath to the fenestration, providing stability while target vessel catheterization takes place and avoiding the use of a large sheath in the contralateral groin. A third wire attached to the inside of the top cap facilitates its safe retrieval via a 6-mm balloon. The preloaded FSG was used in 5 male patients (mean age 75.6 years) with either juxtarenal aneurysms (n = 2) or aneurysms previously treated with infrarenal stent-grafts that had developed type I endoleak (n = 3). In 3 cases, a double fenestrated stent-graft was required, and in 2 cases a triple fenestrated device was deployed, with scallops for the superior mesenteric or celiac arteries., Results: Sixteen of 17 target vessels were preserved, and all aneurysms were successfully excluded with no endoleak at completion. In 2 patients, tortuosity encountered during device delivery caused twisting of the wires within the preloaded FSG, preventing successful advancement of a sheath over a preloaded wire. An approach from the contralateral groin was necessary to complete the procedure in 1 case, but the target vessel was lost in the other., Conclusion: The use of a preloaded FSG is feasible and facilitates the catheterization of fenestrations and of target arteries. This method has the potential to reduce procedure times and lower the risk of intraoperative lower limb ischemia.

In situ fenestration of aortic stent grafts has the potential to allow for continued perfusion of supra-aortic trunks, without the need for extra-anatomic bypass, and without the need for custom-made devices. Angulation of the target vessel relative to the arch is an obstacle to success with this technique. In this report, we describe a case of successful in situ fenestration of the left subclavian artery (LSA) in a patient with an aortic arch aneurysm, treated with an endovascular stent graft. We outline a novel technique using through and through wire access and a pre-curved semi-rigid sheath, which allows successful access to the lumen of the aortic stent graft, despite an acute angle at the take-off of the LSA., (Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.)

Objective: A prototype ready-to-fenestrate stent graft (RFSG) was designed with a fixed scallop, and eight potential fenestrations allowing for variation in the position of each renal artery (RA) relative to the superior mesenteric artery (SMA). We aimed to determine the proportion of juxtarenal aneurysms treatable using this potentially 'off-the-shelf' device., Methods: A total of 439 consecutive orders for custom-made devices were analysed, and positions for potential fenestrations in the RFSG were determined, based on the most frequent anatomical target vessel variations: a fixed SMA scallop 12 mm deep at 12:00, RA fenestrations at 9:15, 10:15 (target within the range 8:45-10:45), 2:15 and 3:15 (target within the range 1:45-3:45), each either 19 or 28 mm from the graft edge (GE); (within the range 15-32 mm), and 6 x 8 mm in diameter. Proximal diameters of 24, 26, 28, 30, 32 and 36 mm were chosen., Results: Of the 439 plans, 372 standard juxtarenal (SJR) cases, defined by the inclusion of a scallop and 0, 1 or 2 small fenestrations (12%, 13% and 75% of the cases, respectively) were identified and used to test the applicability of the model. Mean CP (clock position) for right RA was 9:30, for the left RA 3:00, being a mean of 21 +/- 5 and 22 +/- 5 mm, respectively from the GE. RA CP was within the RFSG range in 86% (right) and 88% (left) of the cases, with 96% and 98%, respectively, within the allowable distance from the GE. A total of 81% of all SJR cases were potentially treatable using the RFSG model., Conclusions: An RFSG device would allow for the treatment of the majority of juxtarenal aortic aneurysms, which currently require custom-made devices.

This research examined the ability of young (N = 96) children to learn about a change in the location of a hidden object, either via an adult's verbal testimony or from direct observation. Thirty-month-olds searched with equal accuracy whether they were told about the change or directly observed it. By contrast, when 23-month-olds were told about the change of location, they often returned to the container where they had last observed the object--even when that container was visibly empty. When interference from prior observational encoding was minimized, 23-month-olds, and even 19-month-olds, successfully updated their knowledge of the object's location on the basis of language. The processing demands of updating experience-based representations from new verbal information are discussed.

Three- and 4-year-old children were asked to judge which of a set of 3 lines was the longest, both independently and in the face of an inaccurate consensus among adult informants. Children were invariably accurate when making independent judgments but sometimes deferred to the inaccurate consensus. Nevertheless, the deference displayed by both age groups proved to be circumscribed. When asked to solve a practical problem--selecting the longest strip to build an adequate bridge--both groups relied on their own perceptual judgment, regardless of whether they had deferred to the inaccurate consensus. Confirming earlier meta-analytic findings with adults, the rate of deference was greater among Asian American children as compared with Caucasian American children.

Mutational inactivation of genes controlling the DNA-damage response contributes to cancer susceptibility within families and within the general population as well as to sporadic tumorigenesis. Claspin (CLSPN) encodes a recently recognized mediator protein essential for the ATR and CHK1-dependent checkpoint elicited by replicative stress or the presence of ssDNA. Here, we describe a study to determine whether mutational disruption of CLSPN contributes to cancer susceptibility and sporadic tumorigenesis. We resequenced CLSPN from the germline of selected cancer families with a history of breast cancer (n = 25) or a multicancer phenotype (n = 46) as well as from a panel of sporadic cancer cell lines (n = 52) derived from a variety of tumor types. Eight nonsynonymous variants, including a recurrent mutation, were identified from the germline of two cancer-prone individuals and five cancer cell lines of breast, ovarian, and hematopoietic origin. None of the variants was present within population controls. In contrast, mutations were rare within genes encoding the CLSPN-interacting protein ATR and its binding partner ATRIP. One variant of CLSPN, encoding the I783S missense mutation, was defective in its ability to mediate CHK1 phosphorylation following DNA damage and was unable to rescue sensitivity to replicative stress in CLSPN-depleted cells. Taken together, these observations raise the possibility that CLSPN may encode a component of the DNA-damage response pathway that is targeted by mutations in human cancers, suggesting the need for larger population-based studies to investigate whether CLSPN variants contribute to cancer susceptibility.

I consider three issues: children's attribution of belief-based emotions, the contribution of language input to children's developing theory of mind, and the default settings we assume in our dealings with the world. I ask whether the proposals made by Mitchell, Currie and Ziegler can help throw light on each issue (Mitchell, Currie, & Ziegler, 2009).

In two experiments, children aged 3, 4 and 5 years (N = 61) were given conflicting information about the names and functions of novel objects by two informants, one a familiar teacher, the other an unfamiliar teacher. On pre-test trials, all three age groups invested more trust in the familiar teacher. They preferred to ask for information and to endorse the information that she supplied. In a subsequent phase, children watched as the two teachers differed in the accuracy with which they named a set of familiar objects. Half the children saw the familiar teacher name the objects accurately and the unfamiliar teacher name them inaccurately. The remaining half saw the reverse arrangement. In post-test trials, the selective trust initially displayed by 3-year-olds was minimally affected by this intervening experience of differential accuracy. By contrast, the selective trust of 4- and 5-year-olds was affected. If the familiar teacher had been the more accurate, selective trust in her was intensified. If, on the other hand, the familiar teacher had been the less accurate, it was undermined, particularly among 5-year-olds. Thus, by 4 years of age, children trust familiar informants but moderate that trust depending on the informants' recent history of accuracy or inaccuracy.

In two experiments, 3- and 4-year-olds were tested for their sensitivity to agreement and disagreement among informants. In pretest trials, they watched as three of four informants (Experiment 1) or two of three informants (Experiment 2) indicated the same referent for an unfamiliar label; the remaining informant was a lone dissenter who indicated a different referent. Asked for their own judgment, the preschoolers sided with the majority rather than the dissenter. In subsequent test trials, one member of the majority and the dissenter remained present and continued to provide conflicting information about the names of unfamiliar objects. Children remained mistrustful of the dissenter. They preferred to seek and endorse information from the informant who had belonged to the majority. The implications and scope of children's early sensitivity to group consensus are discussed.

To determine whether children retain a preference for a previously accurate informant only in the short term or for long-term use, 3- and 4-year-old children were tested in two experiments. In both experiments, children were given accuracy information about two informants and were subsequently tested for their selective trust in the two informants (Experiment 1: immediately, 1 day and 1 week later; Experiment 2: immediately, 4 days and 1 week later). Both age groups preferred to trust the accurate informant not only immediately after receiving accuracy information but also at subsequent time-points. Children who were immediately able to explicitly identify the accurate informant were significantly more likely to seek and accept information from her 1 week later. However, even when they had not been asked to explicitly identify the accurate informant both age groups still maintained their preference for her. Thus, by 3 years of age, children spontaneously choose a previously accurate informant up to 1 week after exposure to information regarding her accuracy.

Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of amyloid-beta plaques, neuronal loss, and inflammation. The exact events that lead to the neuronal dysfunction and loss are not completely understood. However, pro-inflammatory cytokines, such as interleukin-1beta, interleukin-6, and tumor necrosis factor alpha, are increased in AD, along with gene expression of major histocompatibility complex (MHC) class II molecules and macrophage migration inhibitory factor (MIF). MHC class II molecules are found in microglia of the brain, while MIF is found in both microglia and neurons of the hypothalamus, hippocampus, and cortex. MIF is not only a lymphocyte mediator but also a pituitary factor with endocrine properties and can mediate phosphorylation of the extracellular signal-regulated kinase-1/2 MAP kinases pathway. In this study, we looked at CD74, an integral membrane protein that acts as both a chaperone for MHC class II molecules as well as a receptor binding site for MIF. CD74 was recently found to be increased in microglia in AD cases compared to age-matched controls, but has not been reported in neurons. In our analysis, immunohistochemistry revealed a significant increase in CD74 primarily in neurofibrillary tangles, amyloid-beta plaques, and microglia. This is the first finding to our knowledge that CD74 is increased in neurons of AD cases compared to age-matched control cases.