Search

Your search keyword '"Hartmann, Laura"' showing total 562 results
Start Over Author "Hartmann, Laura"
562 results on '"Hartmann, Laura"'

101. Munich Security Report 2020: Westlessness

Author

Bunde, Tobias, primary, Carr, Randolf, additional, Eisentraut, Sophie, additional, Erber, Christoph, additional, Hammelehle, Julia, additional, Hartmann, Laura, additional, Kabus, Juliane, additional, Stärk, Franziska, additional, and Voje, Julian, additional

Published
2020
Full Text
View/download PDF

105. A study on the communication management in the Federal University of Santa Maria through local media outlets

Author

Hartmann, Laura Beatriz, Battistella, Luciana Flores, Mortari, Elisângela Carlosso Machado, and Silva, Gilson Luiz Piber da

Subjects
Media, CIENCIAS SOCIAIS APLICADAS::ADMINISTRACAO::ADMINISTRACAO PUBLICA [CNPQ], Image audit, Gestão de comunicação, Mídia, Communication management, Auditoria de imagem
Abstract

This research aimed to answer the following question: "How was the communication management in the Federal University of Santa Maria (UFSM), headquartered in Santa Maria, according to what was published by the local media outlets during the year of 2016?". Therefore, the purpose of the study was to investigate the communication management in the Federal University of Santa Maria through local vehicles of mass communication. Consequently, the theoretical framework used in this research was built upon the following concepts: institutional image (Brandão), communication and public interest (Faria), and citizenship (Kocourek). The methodology was based on two specific research tools, i.e., image audit (Duarte) and content analysis (Bardin). The main results are summarized as follows: the communication management in the Federal University of Santa Maria during that period of time was neutral, characterized by institutional themes, greater diffusion of the newspaper “Diário de Santa Maria” as well as little use of material made available by the University. These results suggest the need of content adaptation for the press, restructuring of the UFSM tool in the Media, and offer of unique news scripts. Esta pesquisa almejou resolver o problema “Como se deu a gestão da comunicação da Universidade Federal de Santa Maria, campus sede, divulgada na imprensa local durante o ano de 2016?”, tendo como objetivo estudar a gestão da comunicação da UFSM, campus Santa Maria, por meio dos veículos de comunicação de massa locais. Para tanto, o referencial teórico adotado permeia as temáticas de imagem institucional (Brandão), comunicação, interesse público (Faria) e cidadania (Kocourek). A metodologia empregada foi a de auditoria de imagem (Duarte) e a de análise de conteúdo (Bardin). Como resultados principais, pode-se referenciar que a gestão da comunicação da UFSM, durante o período considerado, foi neutra, com temática Institucional, maior divulgação do Diário de Santa Maria e com pouco aproveitamento de material disponibilizado pela universidade. Tais resultados levam essa pesquisa a propor adaptação do conteúdo para envio à imprensa, reestruturação da ferramenta UFSM na Mídia e oferta de pautas exclusivas.

Published
2018

106. Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display

Author

Wickström, Stina L., primary, Lövgren, Tanja, additional, Volkmar, Michael, additional, Reinhold, Bruce, additional, Duke-Cohan, Jonathan S., additional, Hartmann, Laura, additional, Rebmann, Janina, additional, Mueller, Anja, additional, Melief, Jeroen, additional, Maas, Roeltje, additional, Ligtenberg, Maarten, additional, Hansson, Johan, additional, Offringa, Rienk, additional, Seliger, Barbara, additional, Poschke, Isabel, additional, Reinherz, Ellis L., additional, and Kiessling, Rolf, additional

Published
2019
Full Text
View/download PDF

110. Synthesis of Porphyrin and Bacteriochlorin Glycoconjugates through CuAAC Reaction Tuning

Author

Bennion, Matthew C., primary, Burch, Morgan A., additional, Dennis, David G., additional, Lech, Melissa E., additional, Neuhaus, Kira, additional, Fendler, Nikole L., additional, Parris, Matthew R., additional, Cuadra, Jessica E., additional, Dixon, Charlie F., additional, Mukosera, George T., additional, Blauch, David N., additional, Hartmann, Laura, additional, Snyder, Nicole L., additional, and Ruppel, Joshua V., additional

Published
2019
Full Text
View/download PDF

114. Cancer Neoepitopes for Immunotherapy : Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display

Author

Wickstrom, Stina L., Lövgren, Tanja, Volkmar, Michael, Reinhold, Bruce, Duke-Cohan, Jonathan S., Hartmann, Laura, Rebmann, Janina, Mueller, Anja, Melief, Jeroen, Maas, Roeltje, Ligtenberg, Maarten, Hansson, Johan, Offringa, Rienk, Seliger, Barbara, Poschke, Isabel, Reinherz, Ellis L., Kiessling, Rolf, Wickstrom, Stina L., Lövgren, Tanja, Volkmar, Michael, Reinhold, Bruce, Duke-Cohan, Jonathan S., Hartmann, Laura, Rebmann, Janina, Mueller, Anja, Melief, Jeroen, Maas, Roeltje, Ligtenberg, Maarten, Hansson, Johan, Offringa, Rienk, Seliger, Barbara, Poschke, Isabel, Reinherz, Ellis L., and Kiessling, Rolf

Abstract

Tumor-infiltrating lymphocytes (TIL) are considered enriched for T cells recognizing shared tumor antigens or mutation-derived neoepitopes. We performed exome sequencing and HLA-A*02:01 epitope prediction from tumor cell lines from two HLA-A2-positive melanoma patients whose TIL displayed strong tumor reactivity. The potential neoepitopes were screened for recognition using autologous TIL by immunological assays and presentation on tumor major histocompatibility complex class I (MHC-I) molecules by Poisson detection mass spectrometry (MS). TIL from the patients recognized 5/181 and 3/49 of the predicted neoepitopes, respectively. MS screening detected 3/181 neoepitopes on tumor MHC-I from the first patient but only one was also among those recognized by TIL. Consequently, TIL enriched for neoepitope specificity failed to recognize tumor cells, despite being activated by peptides. For the second patient, only after IFN-gamma treatment of the tumor cells was one of 49 predicted neoepitopes detected by MS, and this coincided with recognition by TIL sorted for the same specificity. Importantly, specific T cells could be expanded from patient and donor peripheral blood mononuclear cells (PBMC) for all neoepitopes recognized by TIL and/or detected on tumor MHC-I. In summary, stimulating the appropriate inflammatory environment within tumors may promote neoepitope MHC presentation while expanding T cells in blood may circumvent lack of specific TIL. The discordance in detection between physical and functional methods revealed here can be rationalized and used to improve neoantigen-targeted T cell immunotherapy.

Published
2019
Full Text
View/download PDF

118. Multidimensional micro- and nano-printing technologies: general discussion

Author

Azevedo, Helena S., primary, Braunschweig, Adam, additional, Byrne, Joseph P., additional, Diaz Fernandez, Yuri, additional, Gildersleeve, Jeff, additional, Hartmann, Laura, additional, Huang, Mia, additional, Nelson, Alshakim, additional, Ravoo, Bart Jan, additional, Schmidt, Stephan, additional, Tammelin, Tekla, additional, Turnbull, W. Bruce, additional, Zheng, Zijian, additional, and Zhou, Dejian, additional

Published
2019
Full Text
View/download PDF

119. Glycan interactions on glycocalyx mimetic surfaces: general discussion

Author

Azevedo, Helena S., primary, Braunschweig, Adam B., additional, Chiechi, Ryan C., additional, Diaz Fernandez, Yuri, additional, Gildersleeve, Jeffrey C., additional, Godula, Kamil, additional, Hartmann, Laura, additional, Miura, Yoshiko, additional, Schmidt, Stephan, additional, Turnbull, W. Bruce, additional, and Zhou, Dejian, additional

Published
2019
Full Text
View/download PDF

120. Preparation of multivalent glycan micro- and nano-arrays: general discussion

Author

Braunschweig, Adam, primary, Byrne, Joseph P., additional, Chiechi, Ryan, additional, Diaz Fernandez, Yuri, additional, Gildersleeve, Jeff, additional, Godula, Kamil, additional, Hartmann, Laura, additional, Mahon, Clare, additional, Miura, Yoshiko, additional, Nelson, Alshakim, additional, Schmidt, Stephan, additional, Turnbull, W. Bruce, additional, Valles, Daniel, additional, Yu, Jin, additional, and Zhou, Dejian, additional

Published
2019
Full Text
View/download PDF

122. New directions in surface functionalization and characterization: general discussion

Author

Azevedo, Helena S., primary, Braunschweig, Adam B., additional, Chiechi, Ryan C., additional, Claridge, Shelley A., additional, Cronin, Leroy, additional, Diaz Fernandez, Yuri, additional, Feizi, Ten, additional, Hartmann, Laura, additional, Huang, Mia, additional, Miura, Yoshiko, additional, Palma, Matteo, additional, Qiu, Xinkai, additional, Ravoo, Bart Jan, additional, Schmidt, Stephan, additional, Turnbull, W. Bruce, additional, Werner, Carsten, additional, Zheng, Zijian, additional, and Zhou, Dejian, additional

Published
2019
Full Text
View/download PDF

124. Controlling the Surface Functionalization of Ultrasmall Gold Nanoparticles by Sequence‐Defined Macromolecules.

Author

Meer, Selina Beatrice, Seiler, Theresa, Buchmann, Christin, Partalidou, Georgia, Boden, Sophia, Loza, Kateryna, Heggen, Marc, Linders, Jürgen, Prymak, Oleg, Oliveira, Cristiano L. P., Hartmann, Laura, and Epple, Matthias

Subjects
MACROMOLECULES, SMALL-angle X-ray scattering, NUCLEAR magnetic resonance spectroscopy, GOLD nanoparticles, TRANSMISSION electron microscopy
Abstract

Ultrasmall gold nanoparticles (diameter about 2 nm) were surface‐functionalized with cysteine‐carrying precision macromolecules. These consisted of sequence‐defined oligo(amidoamine)s (OAAs) with either two or six cysteine molecules for binding to the gold surface and either with or without a PEG chain (3400 Da). They were characterized by 1H NMR spectroscopy, 1H NMR diffusion‐ordered spectroscopy (DOSY), small‐angle X‐ray scattering (SAXS), and high‐resolution transmission electron microscopy. The number of precision macromolecules per nanoparticle was determined after fluorescent labeling by UV spectroscopy and also by quantitative 1H NMR spectroscopy. Each nanoparticle carried between 40 and 100 OAA ligands, depending on the number of cysteine units per OAA. The footprint of each ligand was about 0.074 nm2 per cysteine molecule. OAAs are well suited to stabilize ultrasmall gold nanoparticles by selective surface conjugation and can be used to selectively cover their surface. The presence of the PEG chain considerably increased the hydrodynamic diameter of both dissolved macromolecules and macromolecule‐conjugated gold nanoparticles. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

125. Participatory Children's Radio in the Context of a South African Hospital: An Exploratory Study of Stakeholder Perceptions and Experiences.

Author

Xanthe Hunt, Urgoiti, Gabriel, Laurenzi, Christina, Stewart, Jackie, Tomlinson, Mark, van der Merwe, Amelia, Meintjes, Helen, Skeen, Sarah, and Hartmann, Laura

Subjects
MEDICAL personnel, CHILD patients, HOSPITAL administrators, HOSPITAL personnel, RADIO audiences, MEDICAL care
Abstract

An emerging body of participatory media work aims to access children's subjective experiences. One such medium, children's radio, has increasingly become a significant means of motivating and mobilising vulnerable children in many environments, including hospitals, by creating a space in which they can express their lived experiences. The present study describes stakeholders' perceptions and experiences of a children's hospital-based radio, drawing on interviews with child patients, family members, health providers, and hospital administrators. Seven healthcare workers or hospital administrators, 10 parents or guardians, 10 child presenters, and 12 child listeners were interviewed, and their interviews analysed using thematic analysis. The children's caregivers and healthcare professionals felt that the children's involvement in the radio resulted in significant intrapersonal development. Some benefits of their involvement were pride and increases in confidence. A particularly valuable finding in the present work pertains to the questions of "speaking back" and "voicing": the radio platform allowed children to voice their feelings and opinions in settings in which they are disadvantaged in terms of the power differential between healthcare providers and those who receive medical care. The children found value in the usual power differentials characterising hospitals, being reversed, as ownership of the radio platform inverted their position as the passive recipients of medical questions and treatment and allowed them the power to voice their questions and concerns. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

131. Fucose-Functionalized Precision Glycomacromolecules Targeting Human Norovirus Capsid Protein

Author

Bücher, Katharina Susanne, primary, Yan, Hao, additional, Creutznacher, Robert, additional, Ruoff, Kerstin, additional, Mallagaray, Alvaro, additional, Grafmüller, Andrea, additional, Dirks, Jan Sebastian, additional, Kilic, Turgay, additional, Weickert, Sabrina, additional, Rubailo, Anna, additional, Drescher, Malte, additional, Schmidt, Stephan, additional, Hansman, Grant, additional, Peters, Thomas, additional, Uetrecht, Charlotte, additional, and Hartmann, Laura, additional

Published
2018
Full Text
View/download PDF

135. Consumption Motives in Luxury Marketing : An Analysis of Two Agricultural Markets: Equestrian Sports and Food

Author

Hartmann, Laura Helena and Hartmann, Laura Helena

Subjects
Luxury goods industry--Management, Luxury goods industry, Luxuries--Marketing
Abstract

This dissertation is devoted to attitudes of consumers toward luxury in two agricultural markets, horse sports and foods. Literature postulates a change of perceived luxury definitions and motives for luxury consumption. Accordingly, personally-oriented luxury consumption has gained significance while socially-oriented motives have been pushed into the background. Based on this, the following studies were aimed to reveal how far it has affected the consumer behavior in both agricultural markets. The research results are used to define the target groups for different kinds of luxury marketing and to give recommendations for the design of accordant marketing strategies. The studies provide empirical evidence for the existence of a shift of motives for luxury consumption and luxury definitions away from prestige and conspicuousness toward self-realization, hedonism, intangible values, functionality, sustainability and authenticity. Moreover, the results imply that luxury consumption can be categorized in tangible luxury goods and luxury experience. Despite intersections by means of hedonism and self-realization, the studies revealed differences in the consumption motives for both categories of luxury.

Published
2015

143. Biocompatibility of poly(ethylene glycol) and poly(acrylic acid) interpenetrating network hydrogel by intrastromal implantation in rabbit cornea

Author

Zheng, Luo Luo, Vanchinathan, Vijay, Dalal, Roopa, Noolandi, Jaan, Waters, Dale J., Hartmann, Laura, Cochran, Jennifer R., Frank, Curtis W., Yu, Charles Q., and Ta, Christopher N.

Subjects
Cornea, Implants, Experimental, Materials Testing, Acrylic Resins, Animals, Hydrogels, sense organs, Rabbits, eye diseases, Article, Polyethylene Glycols
Abstract

We evaluated the biocompatibility of a poly(ethylene glycol) and poly(acrylic acid) (PEG/PAA) interpenetrating network hydrogel designed for artificial cornea in a rabbit model. PEG/PAA hydrogel measuring 6 mm in diameter was implanted in the corneal stroma of twelve rabbits. Stromal flaps were created with a microkeratome. Randomly, six rabbits were assigned to bear the implant for 2 months, two rabbits for 6 months, two rabbits for 9 months, one rabbit for 12 months, and one rabbit for 16 months. Rabbits were evaluated monthly. After the assigned period, eyes were enucleated, and corneas were processed for histology and immunohistochemistry. There were clear corneas in three of six rabbits that had implantation of hydrogel for 2 months. In the six rabbits with implant for 6 months or longer, the corneas remained clear in four. There was a high rate of epithelial defect and corneal thinning in these six rabbits. One planned 9-month rabbit developed extrusion of implant at 4 months. The cornea remained clear in the 16-month rabbit but histology revealed epithelial in-growth. Intrastromal implantation of PEG/PAA resulted in a high rate of long-term complications.

Published
2015

144. Luxusmarketing bei Lebensmitteln: Eine empirische Studie zu Dimensionen des Luxuskonsums in Deutschland

Author

Schneider, Thea, Hartmann, Laura, and Spiller, Achim

Subjects
Konsumenten, Dimensionen, luxury marketing, ddc:330, Luxuslebensmittel, luxury food, dimensions, Luxusmarketing, consumers
Abstract

Heutzutage zeigt sich das Ernährungsverhalten der deutschen Konsumenten immer differenzierter und ist mit einem wachsenden Involvement beim Kauf von Lebensmitteln verbunden. In diesem Zusammenhang steigt die Nachfrage nach Qualitätslebensmitteln und Premium-Marken. Für das Marketing im Bereich hochpreisiger Lebensmittel ergibt sich die Frage nach den kaufmotivierenden Produkteigenschaften und der Abgrenzung zum Konsumentenverhalten auf dem allgemeinen Lebensmittelmarkt. Die Konzeptionierung zielgruppenspezifischer Marketingmaßnahmen erfordert die Kenntnis der Einstellungen und Einflussfaktoren von Konsumenten der sogenannten Luxus-Lebensmittel. Bislang sind unseres Wissens hierzu jedoch kaum empirische Studien vorhanden. Basierend auf einer explorativen Faktorenanalyse untersucht die vorliegende Studie, welche Produktdimensionen Konsumenten beim Kauf von hochpreisigen Lebensmitteln leiten und in welchem Zusammenhang diese mit dem allgemeinen Lebensmittelmarkt stehen. Ergebnisse zeigen, dass die Kaufentscheidungen im Hochpreissegment wesentlich von den Attributen Qualität, Nachhaltigkeit und Genusswert beeinflusst werden. Nowadays, the nutritional behavior of German consumers appears to become more differentiated and is moreover related to a high involvement during the purchase of food. As a result, the demand for high quality food products has increased. The question arises which consumption motives are significant in the market for high-price food products and how these differ in comparison to the conventional food market. For the conception of target-group specific marketing strategies, new empirical consumer studies on the market for this so-called luxury food are needed. The developments on the German food market have a high topicality, but there is a lack of those investigations. Based on an explorative factor analysis, this study investigates which product dimensions decisively influence purchase intentions for high-price food products in Germany. Moreover, it highlights the links to the conventional German food market. Results of the analysis show that different dimensions emerge. Especially quality, sustainability and indulgence can be revealed as significant consumption motives on the market for high-price foods.

Published
2015

145. Luxusaffinität deutscher Reitsportler: Implikationen für das Marketing im Reitsportsegment

Author

Hartmann, Laura and Spiller, Achim

Subjects
Reitsportler, Luxusmotive, horse riders, luxury marketing, Luxusgütermarketing, ddc:330, luxury motives, affinity to luxury, Luxusaffinität
Abstract

Der Reitsport wird seit jeher mit Luxus assoziiert. Das Durchschnittseinkommen und die Zahlungsbereitschaften von Reitsportlern sind hoch, zugleich wird ihnen eine Affinität zu Luxusgütern unterstellt. Dies erklärt das Interesse von Luxusgüterherstellern an einer Positionierung ihrer Marketingmaßnahmen im Reitsport. Motiviert durch die vielfache Verknüpfung beider Branchen wurde eruiert, inwieweit deutsche Reiter einem materiellen Luxusverständnis zugewandt sind. Diese Frage ist für Positionierungsstrategien im Luxusmarketing grundlegend, bisher aber kaum empirisch untersucht. Auf Grundlage einer Faktoren- und Clusteranalyse können vier Reitersegmente identifiziert werden, die sich in ihrer Haltung zu Luxus und ihrem sozio-demografischen Profil voneinander unterscheiden. Der Konsum von Luxus und die Ausübung von Reitsport werden eher motiviert durch das Bedürfnis nach Selbstverwirklichung und hedonistischem Erleben. Damit stellt die Gruppe der Reitsportler ein Anwendungsbeispiel für den in der Literatur zwar postulierten, bisher aber wenig empirisch untersuchten Wandel von außengerichteten, sozialen zu innengerichteten, persönlichkeitsorientierten Motiven im Luxuskonsum dar. Es können Implikationen für das Luxusgütermarketing abgeleitet werden. Equestrian sports have always been associated with luxury. Equestrian athletes' average income and their willingness to pay are high. Simultaneously, they are assumed to have an affinity to luxury goods. This explains the interest of luxury goods manufacturers in placing their marketing activities in equestrian sports. Motivated by several links between both fields, this study found out how far German equestrian athletes have been turned to an understanding of material luxury. This is a fundamental question for positioning strategies in luxury marketing, however, it has hardly been studied empirically so far. Based on a factor and cluster analysis, four segments can be identified, differing in attitude to luxury and socio-demographic profiles. Consuming luxury and exercising equestrian sports is rather motivated by the need for self-realization and hedonism. This means the group of riders being an application example of the change from external, social motives towards internal personality-related motives in luxury consumption. Implications for luxury marketing are derived.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results