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Aurelius Victor’s Liber de Caesaribus is a historical work of lives of Roman emperors from Augustus to Constantius II. To examine the features of the sources and the signification of this book is the purpose of this thesis. Chapter 1 works on the life of Victor according to other literary works and epigraphic testimonies. Chapter 2 discusses the manuscripts of Liber de Caesaribus. We have now only 2 manuscripts of Liber de Caesaribus, but there was the third one missing after 16th century. Chapter 3 works on sources of Liber de Caesaribus, following earlier studies since the end of 19th century. Victor used various sources as sell as now non-extant Enmann’s Kaisergeschichte. Chapter 4 works on the Kaisergeschichte using the comparisons among Victor, Eutropius and other works to prove its existence. Chapter 5 treats how Victor depict Consantius II. His figure is described with full of praises, but Victor criticizes his servants, his ministers and his entourage in the end of Liber de Caesaribus. Chapter 6 discusses public officials criticized in this work. Victor blames not only the entourage of Constantius II, but also condemned various civil servants and organizations who were his contemporaries. Chapter 7 tries the identifications of people that Victor criticizes in this work, drawing a conclusion that these people were known as corrupted magistrates, and that most of them were enemies of Julien. The purpose of this book is to denounce these incompetent government officials. Thanks to his work, Victor gained the post of governor of Pannonia Secunda under the reign of Julien., Le Liber de Caesaribus d’Aurélius Victor est une œuvre traitant des vies des empereurs romains à partir d’Auguste jusqu’à Constance II. Examiner des particularités sur les sources et la signification de ce livre, c’est le but de cette thèse. Le chapitre 1 traite de la vie de Victor selon les témoignages littéraires et épigraphiques. Le chapitre 2 parle des manuscrits du Livre des Césars. Nous ne possédons aujourd’hui que deux manuscrits de cette œuvre, mais il y en avait un troisième qui a disparu après XVIème siècle. Le chapitre 3 traite des sources du Livre des Césars en regardant les études précédentes depuis la fin du XIXème siècle. Il a utilisé quelques sources diverses ainsi que la Kaisergeschichte d’Enmann, une œuvre perdue. Le chapitre 4 travaille sur la Kaisergeschichte selon Victor, Eutrope etc. pour prouver son existence. Dans le chapitre 5 on étudie comment Victor décrit Constance II. Son portrait dans ce livre est très élogieux, mais Victor critique ses valets, ses ministres et son entourage à la fin de son œuvre. Le chapitre 6 traite des fonctionnaires critiqués dans cette œuvre. Victor blâme non seulement l’entourage de Constance II mais il critique aussi quelques fonctionnaires et les organisations qui étaient contemporaines de Victor. Le chapitre 7 essaie l’identification des gens que Victor critique dans son livre en concluant que les gens critiqués dans ce livre était connus comme les magistrats corrompus, et que la plupart d’entre eux étaient des ennemis de Julien. Le but de son œuvre était la dénonciation de ces mauvais fonctionnaires. Par conséquent, il a obtenu le poste du gouverneur de la Pannonie Seconde sous Julien.

Hiroshi Ikeda,1 Kazuya Ishiguro,1 Tetsuyuki Igarashi,1 Yuka Aoki,1 Toshiaki Hayashi,1 Tadao Ishida,1 Yasushi Sasaki,1,2 Takashi Tokino,2 Yasuhisa Shinomura1 1Department of Gastroenterology, Rheumatology and Clinical Immunology, 2Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Japan Abstract: A 69-year-old man was diagnosed with IgG λ-type multiple myeloma (MM), StageII in October 2010. He was treated with one cycle of high-dose dexamethasone. After three cycles of bortezomib, the patient exhibited slow elevations in the free light-chain levels and developed a significant new increase of serum M protein. Bone marrow cytogenetic analysis revealed a complex karyotype characteristic of malignant plasma cells. To better understand the molecular pathogenesis of this patient, we sequenced for mutations in the entire coding regions of 409 cancer-related genes using a semiconductor-based sequencing platform. Sequencing analysis revealed eight nonsynonymous somatic mutations in addition to several copy number variants, including CCND1 and RB1. These alterations may play roles in the pathobiology of this disease. This targeted next-generation sequencing can allow for the prediction of drug resistance and facilitate improvements in the treatment of MM patients. Keywords: multiple myeloma, drug resistance, genome-wide sequencing, semiconductor sequencer, target therapy

A colorectal cancer-associated 17-1A antigen is an effective therapeutic target with monoclonal antibody (mAb) for preventing the recurrence of colorectal cancer. We evaluated its expression in myeloma cell lines and bone marrow cells from patients with multiple myeloma or primary macroglobulinemia by indirect immunofluorescence assays. Antigen 17-1A was shown positive in 3 out of 4 cell lines tested and in 8 out of 9 bone marrow cell specimens including 6 multiple myelomas, one IgG-producing chronic lymphoproliferation and 2 primary macroglobulinemias. These data suggest that adminisration of mAb 17-1A may be a new feasible immunotherapy to those indolent, but incurable diseases.

We have studied the electronic structure of Mn impurities in GaAs by Mn 2p core-level photoemission spectroscopy. From cluster-model analysis assuming the neutral (Mn3+) or negatively ionized (Mn2+) ground state, electronic structure parameters have been obtained. In either case, the Mn d electron number is evaluated to be ∼5 using the obtained parameters, meaning that the neutral Mn3+ impurity, if it exists, consists of the Mn 3d5 configuration and a valence hole bound to it through p-d hybridization and/or Coulomb interaction. We discuss the exchange interaction between the Mn local spin and the valence hole as well as the stability of the neutral impurity against the ionization of the valence hole.

A method for blood collection from the jugular vein of mice without anesthesia was compared with a tail-incision technique. Jugular vein blood collection allowed withdrawal of almost 15% of the circulating blood volume at a time in less than 1 min. Hemolysis, hematocrit, and plasma thrombin-antithrombin complexes (a marker of blood coagulation) were higher in samples collected from the tail vein than the jugular vein. Mice produced similar plasma corticosterone levels after serial blood collection by either method. Tail incision led to a slight but significant increase in C-reactive protein levels. Using the jugular venipuncture technique, we then performed a pharmacokinetic study and an oral glucose tolerance test. Plasma concentrations of levofloxacin, an antimicrobial agent, were dose-dependently elevated after oral administration, and linear increases in C(max) and AUC were observed. We also confirmed that overall glucose excursion is significantly decreased in mice treated with exendin 4, a glucagon-like peptide 1 agonist. These results indicate that the jugular venipuncture is a useful technique from the point of view of no requirement for anesthetics, serial blood collection at short intervals, large volume of blood collection, quality of sample and animal welfare. This technique is of particular interest for studies that examine time-dependent changes in blood variables.