132 results on '"Hermanns-Lê T"'
Search Results
102. [Let us watch cutaneous cystic lesions. From derision to merit].
- Author
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Hermanns-Lê T, Hermanns JF, Piérard-Franchimont C, Arrese J, and Piérard GE
- Subjects
- Adenocarcinoma pathology, Aged, Cysts, Diagnosis, Differential, Diagnostic Errors, Female, Hemangiosarcoma pathology, Histiocytoma, Benign Fibrous pathology, Humans, Middle Aged, Skin Diseases pathology, Skin Neoplasms pathology, Adenocarcinoma diagnosis, Hemangiosarcoma diagnosis, Histiocytoma, Benign Fibrous diagnosis, Skin Diseases diagnosis, Skin Neoplasms diagnosis
- Abstract
Cutaneous cystic-like lesions do not always correspond to real epithelial cysts. Indeed, the histological examination may identify another benign tumour. But, in some instances, the surprise may be greater. We report three patients in whom lesions suggested clinically small cysts. However, they were malignant neoplasms corresponding to a malignant fibrous histiocytoma, an epithelioid angiosarcoma and a metastatic adenocarcinoma, respectively.
- Published
- 2002
103. Juvenile acanthosis nigricans and insulin resistance.
- Author
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Hermanns-Lê T, Hermanns JF, and Piérard GE
- Subjects
- Acanthosis Nigricans complications, Acanthosis Nigricans pathology, Acanthosis Nigricans therapy, Adolescent, Child, Female, Humans, Male, Obesity complications, Skin pathology, Acanthosis Nigricans metabolism, Insulin Resistance
- Abstract
Acanthosis nigricans in obese adolescents is frequently associated with hyperinsulinemia and insulin resistance. We report three cases of this condition. In the early stage the skin lesions appeared to be erythematous and pruritic, mimicking an inflammatory dermatitis. Dietary control and oral metformin hydrochloride markedly improved the lesions. Topical calcipotriol may also help to control the skin condition.
- Published
- 2002
- Full Text
- View/download PDF
104. Factor XIIIa-positive dendrocyte rarefaction in Ehlers-Danlos syndrome, classic type.
- Author
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Hermanns-Lê T and Piérard GE
- Subjects
- Adolescent, Adult, Antigens, CD34 analysis, Biomarkers analysis, Child, Dendritic Cells ultrastructure, Dermis pathology, Ehlers-Danlos Syndrome metabolism, Ehlers-Danlos Syndrome pathology, Female, Humans, Immunohistochemistry, Male, Vimentin analysis, Dendritic Cells chemistry, Ehlers-Danlos Syndrome diagnosis, Factor XIIIa analysis
- Abstract
The Ehlers-Danlos syndrome (EDS) represents a heterogeneous group of connective tissue disorders recognized by distinct clinical, microscopic, and biochemical aspects. In particular, some histologic and ultrastructural clues have been reported in the literature. We present a novel immunohistochemical aid to the diagnosis of the most frequent type of EDS. Factor XIIIa-positive dendrocytes are almost absent in the reticular dermis and markedly reduced in number and size in the adventitial dermis. By contrast, the densities of vimentin-positive cells and CD34-positive cells were unremarkable. The biologic significance of this finding is unknown. However, at least a subset of dermal dendrocytes interacts with fibroblasts. This mechanism could be affected in the classic form of EDS.
- Published
- 2001
- Full Text
- View/download PDF
105. [Image of the month. Tumors and ulcerations in red and white].
- Author
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Goffin V, Hermanns-Lê T, and Piérard GE
- Subjects
- Diagnosis, Differential, Foot pathology, Humans, Knee pathology, Male, Middle Aged, Gout complications, Skin Ulcer pathology
- Published
- 2001
106. Analytic quantification of phototype-related regional skin complexion.
- Author
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Hermanns JF, Petit L, Hermanns-Lê T, and Piérard GE
- Subjects
- Colorimetry instrumentation, Colorimetry methods, Erythema diagnosis, Humans, Melanins analysis, Regression Analysis, Skin chemistry, Skin radiation effects, Spectrophotometry instrumentation, Sunlight, Skin Pigmentation, Spectrophotometry methods
- Abstract
Background/aims: Narrow-band spectrophotometry that yields melanin (M) and erythema (E) indexes is a convenient method for assessing skin colour. The objective of the study was to assess the phenotype-associated body site differences in skin complexion., Method: The Mexameter MX16 was used to record the skin colour in 137 subjects. Evaluations were made on the inner arm, volar forearm, dorsal forearm and forehead., Results: The inner arm and volar forearm had similar values for each of the colorimetric values. The dorsal forearm exhibited the highest M values, and the forehead had the highest E values. Significant positive linear correlations were found between M values from the distinct body sites. The E values showed a correlation only between the inner arm and the volar forearm., Conclusion: Regional skin colour differences are obvious. Sun-exposed skin does not react in the same way on the forearm and forehead. Regional variations in M can be predicted from the innate M value. In contrast, the regional variability in E is highly variable among subjects.
- Published
- 2001
- Full Text
- View/download PDF
107. [Occupational stigmata in instrumental musicians].
- Author
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Claessens N, Hermanns-Lê T, Piérard-Franchimont C, and Piérard GE
- Subjects
- Dermatitis, Occupational pathology, Hand pathology, Humans, Risk Factors, Dermatitis, Occupational etiology, Music
- Abstract
The frequent practice of a music instrument represents a risk for frictional or allergic contact dermatitis. The localisation and type of lesions are often typical for the musician specialty.
- Published
- 2001
108. [How I investigate...cetain skin disorders by ultrastructural examination].
- Author
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Hermanns-Lê T
- Subjects
- Biopsy, Diagnosis, Differential, Humans, Reproducibility of Results, Skin Diseases classification, Microscopy, Electron methods, Skin Diseases pathology
- Abstract
Ultrastructural examination of the skin plays an important role in the diagnosis of some cutaneous and neurologic diseases such as ichthyoses, inherited connective tissue syndromes, non-X histiocytoses, anaplastic tumors, storage disorders, mitochondrial and degenerative neuropathies, POEMS, CADASIL.
- Published
- 2000
109. [Bites from stealthy arthropods from here to there].
- Author
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Hermanns-Lê T, Hermanns JF, Kharfi M, Fazaa B, Piérard-Franchimont C, and Piérard GE
- Subjects
- Diagnosis, Differential, Humans, Skin Diseases etiology, Insect Bites and Stings, Spider Bites
- Abstract
Stealthy arthropods perpetrate their insults to humans through three distinct mechanisms including bites, stings or simple contact with the skin. The present review is a summary of the bite effects of spiders and diptera.
- Published
- 2000
110. [Uncertainty of practitioners between rational and evidence-based dermatology].
- Author
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Piérard GE, Arrese JE, Hermanns-Lê T, and Piérard-Franchimont C
- Subjects
- Decision Making, Humans, Pathology trends, Dermatology trends, Evidence-Based Medicine
- Abstract
In opposition to intuitive and empirical approaches, rigorous medicine relies on two axes of development. Evidence-Based Medicine is currently put forward. However, it can not replace rational medicine rooted in physiopathological explanations. Dermatology does not escape such conceptual duality. Dermatopathology is one major pillar of rational dermatology. Such situation is jeopardized by health planners who deny the perennial skill of dermatologists and concede hegemony of dermatopathology to general pathologists.
- Published
- 2000
111. [Relativity of the management of skin cancers. A plea for synergy between general practitioners and the dermatologist-oncologist].
- Author
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Piérard GE, Piérard-Franchimont C, Cornil F, Darcis JM, Deleixhe-Mauhin F, Delvoye P, Gerardy-Goffin F, Giet-Lesuisse M, Goffin V, Henry F, Hermanns JF, Hermanns-Lê T, Marchoul JC, Martalo O, Nikkels AF, Nikkels-Tassoudji N, Paquet P, and Soyeur-Broux M
- Subjects
- Humans, Interprofessional Relations, Patient Care Planning, Skin Neoplasms therapy, Dermatology, Medical Oncology, Physicians, Family, Skin Neoplasms diagnosis
- Abstract
The clinical diagnosis and treatment of cutaneous cancers represent a frequent situation in cancerology. About one third of all human cancers take their origin from the skin. The general practitioner and the dermatologist-oncologist play the key role in that field of health care.
- Published
- 2000
112. [Tea time ... a privileged moment in preventing cancer?].
- Author
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Piérard GE, Hermanns JF, Hermanns-Lê T, Goffin V, and Piérard-Franchimont C
- Subjects
- Cell Transformation, Neoplastic, Humans, Neoplasms therapy, Oxidative Stress, Reactive Oxygen Species, Neoplasms prevention & control, Phenols pharmacology, Tea
- Abstract
Several recent epidemiological and biological studies suggest that polyphenols contained in tea exhibit anticarcinogenic effects. The present review is a synthesis of the current information.
- Published
- 2000
113. Koraxitrachitic syndrome: a syndromic form of self-healing collodion baby with residual dappled atrophy of the derma.
- Author
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Verloes A, Hermanns-Lê T, Lesenfants S, Lombet J, Lamotte PJ, Crèvecoeur-Liégeois C, Duchesne B, and Piérard GE
- Subjects
- Abnormalities, Multiple genetics, Abnormalities, Multiple pathology, Adult, Female, Humans, Ichthyosis, Lamellar genetics, Ichthyosis, Lamellar pathology, Infant, Newborn, Male, Pigmentation Disorders genetics, Pigmentation Disorders pathology, Pigmentation Disorders physiopathology, Skin Abnormalities genetics, Skin Abnormalities pathology, Syndrome, Abnormalities, Multiple physiopathology, Ichthyosis, Lamellar physiopathology, Skin Abnormalities physiopathology
- Abstract
We report on a child with a generalized skin disorder associated with other minor anomalies. At birth, the child presented as a collodion baby, with patchy erythema, generalized irregular dermal atrophy, alopecia, absent eyelashes and eyebrows, and conjunctival pannus. He also had hypertelorism, prominent nasal root, large mouth, micrognathia, brachydactyly, syndactyly involving all interdigital spaces, and camptodactyly of fingers III-V. The hyperkeratotic membrane thinned progressively, leaving a mottled reticulated skin atrophy, with patchy areas of yellowish hyperpigmentation and papyraceous areas. Hair and nails were dystrophic. Mental development was borderline normal. The histological hallmarks of the skin manifestations combined orthokeratotic hyperkeratosis and marked atrophy of the dermis. The dermal extracellular matrix was immature, and factor XIII-a positive dendrocytes were rare and globular rather than dendritic. We frame as a hypothesis that the disease is due to or associated with a defect in maturation of a subset of dermal dendrocytes during fetal life. This entity may be designed as the koraxitrachitic syndrome (kappaomicronrhoalphaxi:grapnel- taurhoalphachiiotatauepsilonsigma: roughness), (Copyright 1999 Wiley-Liss, Inc.)
- Published
- 1999
114. [Small handbook of dioxin et alias].
- Author
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Piérard GE, Hermanns JF, Hermanns-Lê T, and Piérard-Franchimont C
- Subjects
- Dioxins chemistry, Environmental Pollutants pharmacology, Food Chain, Humans, Neoplasms etiology, Public Health, Tissue Distribution, Dioxins adverse effects, Environmental Pollutants adverse effects
- Abstract
Dioxin is the common name for a series of 75 dibenzodioxins, 135 dibenzofurans and 209 PCBs. Among these chemicals, less than 30 prove to be toxic. Those molecules can act as hormone disrupters, suppress the immune system, alter the physiology of the sebaceus follicle and participate in the carcinogenesis of sacromas, lymphomas and some carcinomas. They may be responsible for some birth defects. In some regions of the world, dioxins and dioxin-like chemicals are present in the environment, the food chain and body tissues at doses at or near at the level supposed to cause harm to public health.
- Published
- 1999
115. [Cutaneous melanomas, a spectrum of emerging cancers in women of Wallonia. Outlook by the Mosan Study Group of Pigmented Neoplasms].
- Author
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Piérard-Franchimont C, Arrese JE, Cornil F, Damseaux M, Darcis JM, Deleixhe-Mauhin F, Delvoye P, Fraiture AL, Gerardy-Goffin F, Giet-Lesuisse M, Goffin V, Henry F, Hermanne-Wolff P, Hermanns JF, Hermanns-Lê T, Heymans O, Letawe C, Nikkels A, Nikkels-Tassoudji N, d'Hauterive-Willemaers VP, Rakic L, Soyeur-Broux M, Sproten G, Uhoda I, and Piérard GE
- Subjects
- Carcinoma, Squamous Cell epidemiology, Carcinoma, Squamous Cell prevention & control, Carcinoma, Squamous Cell therapy, Evidence-Based Medicine, Female, Humans, Incidence, Melanoma prevention & control, Melanoma therapy, Skin Neoplasms prevention & control, Skin Neoplasms therapy, Ultraviolet Rays adverse effects, Melanoma epidemiology, Skin Neoplasms epidemiology, Sunscreening Agents, Women's Health
- Abstract
The Mosan Study Group of Pigmented Neoplasms was founded about 15 years ago. It has collected more than 20,000 cutaneous malignancies including melanomas and basal and squamous cell carcinomas. The incidence of these cancers is on the rise in Wallonia. In particular, malignant melanomas represent a spectrum of emerging cancers characterized by a proteiform biological outcome. They mostly affect young women. The major risk factor appears to be iterative and unwise ultraviolet exposures. The prevention of melanomas is basically founded on such a dogma and accordingly relies on sunscreens. However, controversies about their beneficial effects are rife and fueled by axiomas and contradictory sophisms. At the exception of surgery, the therapeutic options for the diverse types of melanomas do not yet fulfill the scope of evidence-based medicine.
- Published
- 1999
116. [Dermatologic diseases of the nipple and areola].
- Author
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Fraiture AL, Piérard-Farnchimont C, Hermanns-Lê T, Damseaux M, and Piérard GE
- Subjects
- Breast Neoplasms pathology, Diagnosis, Differential, Female, Humans, Paget's Disease, Mammary pathology, Breast Diseases pathology, Nipples pathology, Skin Diseases pathology
- Abstract
Several diseases of the nipple and areola have a specific dermatological presentation. They may be classified into five main categories including dysembryoplasias, mastalgia, inflammatory dermatoses, hyperkeratoses and neoplasms.
- Published
- 1999
117. [Skin during pregnancy].
- Author
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Piérard-Franchimont C, Hermanns-Lê T, and Piérard GE
- Subjects
- Female, Humans, Pregnancy Complications, Infectious, Skin blood supply, Skin Diseases drug therapy, Pregnancy physiology, Skin Diseases etiology, Skin Physiological Phenomena
- Abstract
Hormonal modifications associated with pregnancy induce some physiopathological changes in the skin. The main alterations occur in the pigmentary and vascular systems. Other changes affect the dermis, hair growth and the sebaceous gland activity. Some infectious and auto-immune dermatoses are influenced by pregnancy and vice versa. Various dermatological treatments have a negative impact on the foetus. In addition, there exists a small number of specific dermatoses of pregnancy.
- Published
- 1999
118. [Cutaneous-lymph node Kikuchi-Fujimoto disease].
- Author
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Letawe C, Piérard-Franchimont C, Rustom KA, Hermanns-Lê T, and Piérard GE
- Subjects
- Adult, Biopsy, Follow-Up Studies, Histiocytic Necrotizing Lymphadenitis pathology, Humans, Lymph Nodes pathology, Male, Remission, Spontaneous, Skin pathology, Histiocytic Necrotizing Lymphadenitis diagnosis
- Abstract
Introduction: The subacute necrotizing histiocytic lymphadenitis was reported for the first time in 1972 in Japan by Kikuchi and by Fujimoto and his colleagues. This idiopathic disease can affect the skin. We report a case of Kikuchi-Fujimoto disease with skin and lymph node involvement., Observation: The Yemani man developed cervical lymphadenitis and arciform papulo-nodular lesions of the face. The histologic examination revealed a necrotizing lymphadenitis with blast cells but devoid of neutrophils. The cutaneous involvement corresponded to an angiocentric infiltration by mononuclear cells among which plasmacytoid cells and caryorrhexis were recognized. A spontaneous resolution of the disease occurred spontaneously within three months., Commentary: The clinical and histologic aspects of the present case resemble in part the presentation of lupus erythematosus. However, some distinctive features suggest Kikuchi-Fujimoto disease cannot be termed a classical type of lupus erythematosus.
- Published
- 1999
119. [Cutaneous zoonoses transmitted by dogs and cats].
- Author
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Piérard GE, Piérard-Franchimont C, Arrese JE, Nikkels AF, Paquet P, and Hermanns-Lê T
- Subjects
- Animals, Bacterial Infections transmission, Cats, Dermatomycoses transmission, Dogs, Ectoparasitic Infestations transmission, Humans, Cat Diseases transmission, Dog Diseases transmission, Zoonoses transmission
- Abstract
Pets like dogs and cats are responsible for a series of zoonotic disorders. Some of these diseases are inflicted by bites, scratches or licking. Others result from a close contact with fur, or are transmitted by ectoparasites or by the contaminated environment. Some systemic infectious and parasitic diseases are transmitted from animals to humans and vice versa. Such situation may lead to endemic problems in some communities.
- Published
- 1998
120. Podophyllotoxin-induced acantholysis and cytolysis in a skin equivalent model.
- Author
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Hermanns-Lê T, Arrese JE, Goffin V, and Piérard GE
- Subjects
- Acantholysis pathology, Cells, Cultured drug effects, Connective Tissue drug effects, Connective Tissue pathology, Cosmetics toxicity, Epidermis drug effects, Epidermis pathology, Fibroblasts ultrastructure, Humans, Keratinocytes ultrastructure, Acantholysis chemically induced, Animal Testing Alternatives, Cytotoxins toxicity, Fibroblasts drug effects, Keratinocytes drug effects, Podophyllotoxin toxicity, Skin, Artificial
- Abstract
Skin equivalent models are used for a wide variety of pharmacotoxicological trials. The present study was performed to assess morphologically the effect of podophyllotoxin on human bioengineered skin. The untreated model exhibited many resemblances with the parent tissues, although the epidermal differentiation was slightly impaired at the ultrastructural level. The penetration of podophyllotoxin and its biological effects inside the model appeared largely increased compared to the clinical experience with the drug. Acantholysis and cytolytic changes were prominent mimicking the effect of cantharidin. The exaggerated response of many skin equivalents to various compounds shed some doubts on the validity of the model when it is used to show efficacy rather than toxicity. This might apply to claims of efficacy for cosmetic compounds. The effect of cosmetic additives cannot be validated by such approach alone.
- Published
- 1998
- Full Text
- View/download PDF
121. [Langerhans histiocytosis and acute monoblastic leukemia type LMA4].
- Author
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Hermanns-Lê T, Arrese JE, and Piérard GE
- Subjects
- Biopsy, Fatal Outcome, Female, Histiocytosis, Langerhans-Cell drug therapy, Histiocytosis, Langerhans-Cell pathology, Humans, Leukemia, Monocytic, Acute blood, Leukemia, Monocytic, Acute classification, Leukemia, Monocytic, Acute drug therapy, Middle Aged, Skin Diseases drug therapy, Skin Diseases pathology, Histiocytosis, Langerhans-Cell etiology, Leukemia, Monocytic, Acute etiology, Myelodysplastic Syndromes complications, Skin Diseases etiology
- Abstract
Introduction: Cutaneous manifestations of myelodysplastic syndromes are rare and polymorphous. They can be the direct expression of the hematological disease or represent signs of a vasculitis or a neutrophilic syndrome. Myelodysplastic syndromes progress sometimes toward an acute leukemia., Observation: A 53-year-old woman suffering from myelodysplastic syndrome presented for several months a cutaneous vasculitis without any histological specificity. In time, such presentation was complicated by the simultaneous occurrence of a cutaneous Langerhans cell histiocytosis and an acute monoblastic leukemia type LMA 4. The disease was rapidly fatal., Discussion: The complication of a myelodysplastic syndrome by concurrent Langerhans cell histiocytosis and acute monoblastic leukemia suggests a pathogenic relationship between these two latter disorders.
- Published
- 1998
122. [Synopsis of primary cutaneous lymphomas].
- Author
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Piérard GE, Hermanns-Lê T, Arrese JE, and Piérard-Franchimont C
- Subjects
- Humans, Lymphoma, B-Cell classification, Lymphoma, T-Cell, Cutaneous classification, Skin Neoplasms classification, Lymphoma, B-Cell pathology, Lymphoma, T-Cell, Cutaneous pathology, Skin Neoplasms pathology
- Published
- 1996
123. Surfactant-induced dermatitis: comparison of corneosurfametry with predictive testing on human and reconstructed skin.
- Author
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Piérard GE, Goffin V, Hermanns-Lê T, Arrese JE, and Piérard-Franchimont C
- Subjects
- Adult, Colorimetry, Cytoplasm drug effects, Cytoplasm ultrastructure, Dermatitis, Irritant pathology, Epidermis drug effects, Epidermis pathology, Female, Humans, Keratinocytes drug effects, Keratinocytes pathology, Male, Patch Tests, Predictive Value of Tests, Skin pathology, Staining and Labeling, Tumor Necrosis Factor-alpha analysis, Water Loss, Insensible drug effects, Dermatitis, Irritant etiology, Hair Preparations adverse effects, Skin drug effects, Skin Tests methods, Surface-Active Agents adverse effects
- Abstract
Background: Surfactants elicit alterations in the stratum corneum. Predictive tests that avoid animal experimentation are needed., Objective: This study compares three methods of rating and predicting shampoo-induced irritation., Methods: Corneosurfametry entails collection of stratum corneum followed by brief contact with diluted surfactants and measurement of variations in staining of samples., Results: Corneosurfametry appears to correlate well with in vivo testing in volunteers with sensitive skin. However, corneosurfametry presents less interindividual variability than in vivo testing and allows better discrimination among mild products. Morphologic information about surfactant-induced loosening of corneocytes may be increased by testing surfactants on human skin equivalent. Results are similar to those provided by specimens used for corneosurfametry., Conclusion: The corneosurfametric prediction of surfactant irritancy correlates with in vivo testing and with in vitro evaluation on human skin equivalent.
- Published
- 1995
- Full Text
- View/download PDF
124. [Leiomyoma, a painful cutaneous tumor].
- Author
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Benzarti H, Mokhtar I, Fazaa B, Hermanns-Lê T, Piérard GE, and Kamoun MR
- Subjects
- Adolescent, Humans, Leiomyoma drug therapy, Leiomyoma surgery, Male, Skin Neoplasms drug therapy, Skin Neoplasms surgery, Leiomyoma pathology, Skin Neoplasms pathology
- Published
- 1994
125. [Hereditary ichthyosis].
- Author
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Piérard GE, Hermanns-Lê T, Deleixhe-Mauhin F, and Piérard-Franchimont C
- Subjects
- Diagnosis, Differential, Female, Humans, Hyperkeratosis, Epidermolytic pathology, Ichthyosiform Erythroderma, Congenital pathology, Ichthyosis diagnosis, Ichthyosis pathology, Ichthyosis Vulgaris pathology, Ichthyosis, X-Linked pathology, Infant, Infant, Newborn, Male, Ichthyosis classification
- Published
- 1994
126. [Hashimoto-Pritzker self-healing reticulohistiocytosis and congenital histiocytosis].
- Author
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Paquet P, Hermanns-Lê T, and Piérard GE
- Subjects
- Humans, Infant, Newborn, Lymphatic Diseases classification, Lymphatic Diseases pathology, Male, Remission, Spontaneous, Skin Neoplasms classification, Skin Neoplasms pathology, Lymphatic Diseases congenital, Skin Neoplasms congenital
- Abstract
Background: Congenital histiocytosis is divided into four entities differing in their clinical and histological features and prognosis. Early, accurate diagnosis is essential for treatment., Case Report: Seven cutaneous nodules were seen in a male neonate. One of these nodules was biopsied on the 7th day of life; it showed the typical findings of Hashimoto-Pritzker reticulohistiocytosis by optical and electron microscopy using immunological markers. The nodules spontaneously disappeared after a few months., Conclusions: Congenital forms of histiocytosis must be accurately characterized. Hashimoto-Pritzker reticulohistiocytosis is a benign and self-healing disease restricted to the skin, while the Letterer-Siwe disease has a completely different course and treatment.
- Published
- 1994
127. [Diagnosis of skin infections caused by simplex-type herpes virus and by varicella zona].
- Author
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Nikkels AF, Hermanns-Lê T, Nikkels-Tassoudji N, and Piérard GE
- Subjects
- Histological Techniques, Humans, Immunohistochemistry methods, Microscopy, Electron, Serologic Tests methods, Virus Cultivation, Herpes Simplex diagnosis, Herpes Zoster diagnosis, Skin Diseases, Viral diagnosis
- Published
- 1993
128. Structure of the dermis in type VIIC Ehlers-Danlos syndrome.
- Author
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Piérard GE, Hermanns-Lê T, Arrese-Estrada J, Piérard-Franchimont C, and Lapière C
- Subjects
- Animals, Basement Membrane pathology, Cattle, Cattle Diseases pathology, Cell Count, Child, Preschool, Collagen ultrastructure, Dendritic Cells pathology, Ehlers-Danlos Syndrome veterinary, Elastic Tissue pathology, Female, Humans, Immunohistochemistry, Mast Cells pathology, Skin ultrastructure, Ehlers-Danlos Syndrome classification, Ehlers-Danlos Syndrome pathology, Skin pathology
- Abstract
This report is the first to study histological, immunopathological, ultrastructural, and morphometric aspects of the abnormal structure of the dermis in Ehlers-Danlos syndrome, type VIIc. This disease, resulting from a defect in procollagen peptidase, resembles dermatosparaxis in animals. Dermal cells were abnormal in many aspects, including their large number, their strong argent affinity, and the occasional presence of oligocilia. Factor XIIIa-positive dendrocytes were, however, few in number. The stroma had many tears resulting from the absence of collagen bundles replaced by a loose meshwork of cauliflower fibrils. The mean collagen area, measured from fibrils, was similar to normal, and the individual values of this parameter were inversely related to the form factor that quantifies irregularity in fibril shape. Basement membranes were also defective, with an apparent paucity or focal absence of type IV collagen and laminin. The biology responsible for these many alterations in dermal structure is complex and not yet understood. The many morphological changes seen in Ehlers-Danlos syndrome, type VIIc, underscore the complexity of cell-matrix interactions in establishing a normal dermis.
- Published
- 1993
- Full Text
- View/download PDF
129. [Ultrastructural study of azidothymidine-induced melanoderma in an AIDS patient].
- Author
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Hermanns-Lê T, Gérardy-Goffin F, Giet-Lesuisse M, and Piérard GE
- Subjects
- Acquired Immunodeficiency Syndrome complications, Adult, Humans, Male, Microscopy, Electron, Pigmentation Disorders chemically induced, Skin ultrastructure, Acquired Immunodeficiency Syndrome drug therapy, Pigmentation Disorders pathology, Zidovudine adverse effects
- Abstract
We report an ultrastructural study of azidothymidine-induced melanoderma. The hyperpigmentation is linked to the presence of numerous single melanosomes and polymelanosomes in keratinocytes at all levels of the epidermis, and in dermal Factor XIIIa-positive dendrocytes. Such observation suggests an increased melanogenesis in melanocytes associated to a defect in the degradation of melanosomes normally occurring during epidermal maturation.
- Published
- 1993
130. Dermatopathological aspects of restrictive dermopathy.
- Author
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Piérard-Franchimont C, Piérard GE, Hermanns-Lê T, Estrada JA, Verloes A, and Mulliez N
- Subjects
- Antigens, Surface analysis, Cell Adhesion Molecules, Neuronal analysis, Dendrites immunology, Epidermis immunology, Hair immunology, Humans, Immunohistochemistry, Infant, Newborn, Leukocyte L1 Antigen Complex, Microscopy, Electron, Skin chemistry, Skin ultrastructure, Skin Diseases immunology, Skin Diseases pathology, Transglutaminases analysis, Skin pathology, Skin Diseases congenital
- Abstract
We present an immunopathological and electronmicroscopic study of the skin of two newborns affected by restrictive dermopathy. Evidence of abnormal maturation was found in the epidermis, cutaneous appendages, dermis, and hypodermis. Our observations confirm two previous descriptions. We emphasize some unreported data concerning the L1 antigen and Factor XIIIa in the skin. The L1 antigen is expressed in the interadnexal epidermis, but not in hair follicles. This is the reverse pattern compared with normal skin. Factor XIIIa is poorly expressed in dermal dendrocytes, which appear rare compared with controls. The multiple defects in maturation found in all cutaneous tissues suggest a qualitative or quantitative aberration in control mechanisms of tissue interactions.
- Published
- 1992
- Full Text
- View/download PDF
131. Restrictive dermopathy, a lethal form of arthrogryposis multiplex with skin and bone dysplasias: three new cases and review of the literature.
- Author
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Verloes A, Mulliez N, Gonzales M, Laloux F, Hermanns-Lê T, Piérard GE, and Koulischer L
- Subjects
- Biopsy, Face abnormalities, Female, Humans, Infant, Newborn, Male, Polyhydramnios, Radiography, Syndrome, Abnormalities, Multiple, Arthrogryposis genetics, Bone Diseases, Developmental diagnostic imaging, Bone Diseases, Developmental genetics, Skin Abnormalities
- Abstract
Restrictive dermopathy is a rare, lethal autosomal recessive syndrome. We report on 3 unrelated affected stillborn infants of consanguineous parents. Clinical findings include a tight, thin, translucent, taut skin, which tears spontaneously in flexion creases, arthrogryposis multiplex congenita (including the temporomandibular joint), enlarged fontanelles, typical face and dysplasia of clavicles and long bones. Histologic abnormalities include hyperplastic, abnormally keratinized epidermis, reduced tonofilaments, thin, compact dermis with hypoplasia of the elastic fibres, and abnormal subcutaneous fat. Fifteen previous cases are reviewed.
- Published
- 1992
- Full Text
- View/download PDF
132. Chemical warfare casualties and yperite-induced xerodermoid.
- Author
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Piérard GE, Dowlati A, Dowlati Y, Piérard-Franchimont C, Hermanns-Lê T, and Letot B
- Subjects
- Adult, Aged, Child, Humans, Keratinocytes ultrastructure, Male, Melanocytes ultrastructure, Skin drug effects, Skin pathology, Skin Diseases pathology, Chemical Warfare, Mustard Gas poisoning, Skin Diseases chemically induced
- Abstract
Chemical warfare agents have been used in recent conflicts. We present a review of the clinical manifestations of mustard gas casualties and we studied the histological presentation of cutaneous lesions. Four groups of alterations were recognized, namely (a) alterations of keratinocytes, (b) epidermal hyperplasia with or without atypia, (c) alterations of the melanocytic system, and (d) structural changes of the dermis.
- Published
- 1990
- Full Text
- View/download PDF
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