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4,415 results on '"Hoffmann, Thomas"'

104. Interim analysis of a pilot study on the feasibility of sentinel lymph node biopsy for squamous cell carcinoma of the nasal cavity and paranasal sinus – SentiNose Pilot

Author

Döscher, Johannes, additional, von Witzleben, Adrian, additional, Burggraf, Manuela, additional, Mlynarcik, Caroline, additional, Thölken, Rubens, additional, Schuler, Patrick J., additional, Laban, Simon, additional, Zenk, Johannes, additional, and Hoffmann, Thomas, additional

Published
2024
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105. Combining CD3 density and PD-L1 expression into one prognostic factor identifies patients with an exceptional prognosis

Author

Laban, Simon, additional, Remark, Romain, additional, Idel, Christian, additional, Ribbat-Idel, Julika, additional, Krupar, Rosemarie, additional, Schröck, Andreas, additional, Klümper, Niklas, additional, Döscher, Johannes, additional, Sikora, Andrew G., additional, Abou Kors, Tsima, additional, von Witzleben, Adrian, additional, Vahl, Julius, additional, Grages, Ayla, additional, Sonntag, Michael, additional, Brunner, Cornelia, additional, Hoffmann, Thomas, additional, Perner, Sven, additional, and Gnjatic, Sacha, additional

Published
2024
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106. Die Weiterbildung „Medikamentöse Tumortherapie“ in deutschen HNO-Abteilungen – eine Umfrage der AG Onkologie der DGHNO

Author

Heil, Jule M., additional, Hoffmann, Thomas, additional, Sharma, Shachi Jenny, additional, Shabli, Sami, additional, Zech, Henrike, additional, Betz, Christian, additional, Wiegand, Susanne, additional, Dietz, Andreas, additional, Braun, Roman, additional, Wolf, Gregor, additional, Eichhorn, Sabine, additional, Park, Jonas, additional, Evers, Theo, additional, Tisch, Matthias, additional, Federspil, Philippe A., additional, Heidemann, Jan, additional, Hofmann, Veit M., additional, Herzog, Michael, additional, Kisser, Ulrich, additional, Abbaspour, Bektasch, additional, Thomas, Jan Peter, additional, Kürten, Cornelius, additional, Lang, Stephan, additional, Warnecke, Athanasia, additional, Lenarz, Thomas, additional, Ivanyi, Philipp, additional, Schapher, Mirco, additional, Traxdorf, Maximilian, additional, Döscher, Johannes, additional, Wollenberg, Barbara, additional, Wirth, Markus, additional, Klußmann, Jens Peter, additional, Theodoraki, Marie-Nicole, additional, and Laban, Simon, additional

Published
2024
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110. The importance of Immunotherapy in 2013/14 vs. 2022/23 – A survey of the DGHNO Oncology Working Group

Author

Grages, Ayla, additional, Heil, Jule M., additional, Kimmeyer, Jana, additional, Hoffmann, Thomas, additional, Sharma, Shachi Jenny, additional, Shabli, Sami, additional, Zech, Henrike, additional, Betz, Christian, additional, Wiegand, Susanne, additional, Dietz, Andreas, additional, Braun, Roman, additional, Wolf, Gregor, additional, Eichhorn, Sabine, additional, Park, Jonas, additional, Evers, Theo, additional, Tisch, Matthias, additional, Federspil, Philippe A., additional, Heidemann, Jan, additional, Hofmann, Veit M., additional, Herzog, Michael, additional, Kisser, Ulrich, additional, Abbaspour, Bektasch, additional, Thomas, Jan Peter, additional, Kürten, Cornelius, additional, Lang, Stephan, additional, Warnecke, Athanasia, additional, Lenarz, Thomas, additional, Schapher, Mirco, additional, Traxdorf, Maximilian, additional, Döscher, Johannes, additional, Thedoraki, Marie-Nicole, additional, Wirth, Markus, additional, Wollenberg, Barbara, additional, Klußmann, Jens Peter, additional, Kurzweg, Thiemo, additional, and Laban, Simon, additional

Published
2024
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113. Der Stellenwert der Immuntherapie 2013/14 vs. 2022/23 – eine Umfrage der AG Onkologie der DGHNO

Author

Grages, Ayla, additional, Heil, Jule M., additional, Kimmeyer, Jana, additional, Hoffmann, Thomas, additional, Sharma, Shachi Jenny, additional, Shabli, Sami, additional, Zech, Henrike, additional, Betz, Christian, additional, Wiegand, Susanne, additional, Dietz, Andreas, additional, Braun, Roman, additional, Wolf, Gregor, additional, Eichhorn, Sabine, additional, Park, Jonas, additional, Evers, Theo, additional, Tisch, Matthias, additional, Federspil, Philippe A., additional, Heidemann, Jan, additional, Hofmann, Veit M., additional, Herzog, Michael, additional, Kisser, Ulrich, additional, Abbaspour, Bektasch, additional, Thomas, Jan Peter, additional, Kürten, Cornelius, additional, Lang, Stephan, additional, Warnecke, Athanasia, additional, Lenarz, Thomas, additional, Schapher, Mirco, additional, Traxdorf, Maximilian, additional, Döscher, Johannes, additional, Thedoraki, Marie-Nicole, additional, Wirth, Markus, additional, Wollenberg, Barbara, additional, Klußmann, Jens Peter, additional, Kurzweg, Thiemo, additional, and Laban, Simon, additional

Published
2024
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117. Advanced training in systemic oncologic therapy in German Otorhinolaryngology departments – A survey of the DGHNO Oncology Working Group

Author

Heil, Jule M., additional, Hoffmann, Thomas, additional, Sharma, Shachi Jenny, additional, Shabli, Sami, additional, Zech, Henrike, additional, Betz, Christian, additional, Wiegand, Susanne, additional, Dietz, Andreas, additional, Braun, Roman, additional, Wolf, Gregor, additional, Eichhorn, Sabine, additional, Park, Jonas, additional, Evers, Theo, additional, Tisch, Matthias, additional, Federspil, Philippe A., additional, Heidemann, Jan, additional, Hofmann, Veit M., additional, Herzog, Michael, additional, Kisser, Ulrich, additional, Abbaspour, Bektasch, additional, Thomas, Jan Peter, additional, Kürten, Cornelius, additional, Lang, Stephan, additional, Warnecke, Athanasia, additional, Lenarz, Thomas, additional, Ivanyi, Philipp, additional, Schapher, Mirco, additional, Traxdorf, Maximilian, additional, Döscher, Johannes, additional, Wollenberg, Barbara, additional, Wirth, Markus, additional, Klußmann, Jens Peter, additional, Theodoraki, Marie-Nicole, additional, and Laban, Simon, additional

Published
2024
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128. Myeloid derived supressor cells contribute to distinct immune profiles in HPV+and HPV- head and neck cancer patients

Author

Kansy, Benjamin, additional, Wehrs, Tim, additional, Si, Yu, additional, Ludwig, Sonja, additional, Dröge, Freya, additional, Haßkamp, Pia, additional, Henkel, Uta, additional, Dominas, Nina, additional, Hoffmann, Thomas, additional, Horn, Peter, additional, Schuler, Martin, additional, Gauler, Thomas, additional, Lindemann, Monika, additional, Lang, Stephan, additional, Bankfalvi, Agnes, additional, and Brandau, Sven, additional

Published
2024
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133. Erstlinien-Standards in der palliativen Systemtherapie in Deutschland- eine Umfrage der AG Onkologie der DGHNO

Author

Sonntag, Michael, additional, Heil, Jule M., additional, Hoffmann, Thomas, additional, Sharma, Shachi Jenny, additional, Shabli, Sami, additional, Zech, Henrike, additional, Betz, Christian, additional, Wiegand, Susanne, additional, Dietz, Andreas, additional, Braun, Roman, additional, Wolf, Gregor, additional, Eichhorn, Sabine, additional, Park, Jonas, additional, Evers, Theo, additional, Tisch, Matthias, additional, Federspil, Philippe A., additional, Heidemann, Jan, additional, Hofmann, Veit M., additional, Herzog, Michael, additional, Kisser, Ulrich, additional, Abbaspour, Bektasch, additional, Thomas, Jan Peter, additional, Kürten, Cornelius, additional, Lang, Stephan, additional, Warnecke, Athanasia, additional, Lenarz, Thomas, additional, Schapher, Mirco, additional, Traxdorf, Maximilian, additional, Döscher, Johannes, additional, Wirth, Markus, additional, Wollenberg, Barbara, additional, Klußmann, Jens Peter, additional, and Laban, Simon, additional

Published
2024
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144. Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.

Author

Emami, Nima C, Kachuri, Linda, Meyers, Travis J, Das, Rajdeep, Hoffman, Joshua D, Hoffmann, Thomas J, Hu, Donglei, Shan, Jun, Feng, Felix Y, Ziv, Elad, Van Den Eeden, Stephen K, and Witte, John S

Subjects
Prostate, Humans, Prostatic Neoplasms, Serine Endopeptidases, Cohort Studies, Gene Expression Profiling, Models, Genetic, European Continental Ancestry Group, Male, Transcriptome
Abstract

Here we train cis-regulatory models of prostate tissue gene expression and impute expression transcriptome-wide for 233,955 European ancestry men (14,616 prostate cancer (PrCa) cases, 219,339 controls) from two large cohorts. Among 12,014 genes evaluated in the UK Biobank, we identify 38 associated with PrCa, many replicating in the Kaiser Permanente RPGEH. We report the association of elevated TMPRSS2 expression with increased PrCa risk (independent of a previously-reported risk variant) and with increased tumoral expression of the TMPRSS2:ERG fusion-oncogene in The Cancer Genome Atlas, suggesting a novel germline-somatic interaction mechanism. Three novel genes, HOXA4, KLK1, and TIMM23, additionally replicate in the RPGEH cohort. Furthermore, 4 genes, MSMB, NCOA4, PCAT1, and PPP1R14A, are associated with PrCa in a trans-ethnic meta-analysis (N = 9117). Many genes exhibit evidence for allele-specific transcriptional activation by PrCa master-regulators (including androgen receptor) in Position Weight Matrix, Chip-Seq, and Hi-C experimental data, suggesting common regulatory mechanisms for the associated genes.

Published
2019

145. Genetic variation in the SIM1 locus is associated with erectile dysfunction

Author

Jorgenson, Eric, Matharu, Navneet, Palmer, Melody R, Yin, Jie, Shan, Jun, Hoffmann, Thomas J, Thai, Khanh K, Zhou, Xujia, Hotaling, James M, Jarvik, Gail P, Ahituv, Nadav, Wessells, Hunter, and Van Den Eeden, Stephen K

Subjects
Contraception/Reproduction, Genetics, Human Genome, Urologic Diseases, Biotechnology, Clinical Research, Prevention, 2.1 Biological and endogenous factors, Aetiology, Aged, Alleles, Body Mass Index, Case-Control Studies, Chromosomes, Human, Pair 6, Cohort Studies, Erectile Dysfunction, Genetic Predisposition to Disease, Genetic Variation, Humans, Leptin, Male, Melanocortins, Middle Aged, Promoter Regions, Genetic, genome-wide association, erectile dysfunction, SIM1, genetic, melanocortin
Abstract

Erectile dysfunction affects millions of men worldwide. Twin studies support the role of genetic risk factors underlying erectile dysfunction, but no specific genetic variants have been identified. We conducted a large-scale genome-wide association study of erectile dysfunction in 36,649 men in the multiethnic Kaiser Permanente Northern California Genetic Epidemiology Research in Adult Health and Aging cohort. We also undertook replication analyses in 222,358 men from the UK Biobank. In the discovery cohort, we identified a single locus (rs17185536-T) on chromosome 6 near the single-minded family basic helix-loop-helix transcription factor 1 (SIM1) gene that was significantly associated with the risk of erectile dysfunction (odds ratio = 1.26, P = 3.4 × 10-25). The association replicated in the UK Biobank sample (odds ratio = 1.25, P = 6.8 × 10-14), and the effect is independent of known erectile dysfunction risk factors, including body mass index (BMI). The risk locus resides on the same topologically associating domain as SIM1 and interacts with the SIM1 promoter, and the rs17185536-T risk allele showed differential enhancer activity. SIM1 is part of the leptin-melanocortin system, which has an established role in body weight homeostasis and sexual function. Because the variants associated with erectile dysfunction are not associated with differences in BMI, our findings suggest a mechanism that is specific to sexual function.

Published
2018

146. A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci

Author

Hoffmann, Thomas J, Choquet, Hélène, Yin, Jie, Banda, Yambazi, Kvale, Mark N, Glymour, Maria, Schaefer, Catherine, Risch, Neil, and Jorgenson, Eric

Subjects
Biological Sciences, Genetics, Obesity, Prevention, Human Genome, Clinical Research, 2.1 Biological and endogenous factors, Underpinning research, Aetiology, 1.1 Normal biological development and functioning, Generic health relevance, Body Mass Index, Body Weight, Ethnicity, Female, Genetic Loci, Genome-Wide Association Study, Humans, Male, Middle Aged, Multifactorial Inheritance, Sex Factors, adult body mass index, adult BMI, genome-wide association study, obesity, Developmental Biology, Biochemistry and cell biology
Abstract

Body mass index (BMI), a proxy measure for obesity, is determined by both environmental (including ethnicity, age, and sex) and genetic factors, with > 400 BMI-associated loci identified to date. However, the impact, interplay, and underlying biological mechanisms among BMI, environment, genetics, and ancestry are not completely understood. To further examine these relationships, we utilized 427,509 calendar year-averaged BMI measurements from 100,418 adults from the single large multiethnic Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. We observed substantial independent ancestry and nationality differences, including ancestry principal component interactions and nonlinear effects. To increase the list of BMI-associated variants before assessing other differences, we conducted a genome-wide association study (GWAS) in GERA, with replication in the Genetic Investigation of Anthropomorphic Traits (GIANT) consortium combined with the UK Biobank (UKB), followed by GWAS in GERA combined with GIANT, with replication in the UKB. We discovered 30 novel independent BMI loci (P < 5.0 × 10-8) that replicated. We then assessed the proportion of BMI variance explained by sex in the UKB using previously identified loci compared to previously and newly identified loci and found slight increases: from 3.0 to 3.3% for males and from 2.7 to 3.0% for females. Further, the variance explained by previously and newly identified variants decreased with increasing age in the GERA and UKB cohorts, echoed in the variance explained by the entire genome, which also showed gene-age interaction effects. Finally, we conducted a tissue expression QTL enrichment analysis, which revealed that GWAS BMI-associated variants were enriched in the cerebellum, consistent with prior work in humans and mice.

Published
2018

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