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488 results on '"Iacobelli, Simona"'

101. Impact of Extramedullary Disease in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation: A Study By the EBMT Chronic Malignancies Working Party

Author

Gagelmann, Nico, primary, Iacobelli, Simona, additional, Koster, Linda, additional, Nahi, Hareth, additional, Stoppa, Anne-Marie, additional, Masszi, Tamás, additional, Caillot, Denis, additional, Lenhoff, Stig, additional, Udvardy, Miklos, additional, Crawley, Charles, additional, Arcese, William, additional, Mariette, Clara, additional, Hunter, Ann, additional, Leleu, Xavier, additional, Schipperus, Martin, additional, Delforge, Michel, additional, Pioltelli, Pietro, additional, Snowden, John A, additional, Itälä-Remes, Maija, additional, Musso, Maurizio, additional, Garderet, Laurent, additional, and Kröger, Nicolaus, additional

Published
2016
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102. A New Clinically-Based Subclassification Proposal in CMML with Significant Prognostic Implications to Overcome the MDS/MPN Categorizing Dilemma

Author

Onida, Francesco, primary, Iacobelli, Simona, additional, Garcia-Manero, Guillermo, additional, Patnaik, Mrinal M, additional, Itzykson, Raphaël, additional, Lasho, Terra L., additional, Nazha, Aziz, additional, Rampal, Raajit K., additional, Sanchez, Matias Eugenio, additional, Jabbour, Elias J., additional, Al Ali, Najla H, additional, Thompson, Zachary, additional, Colla, Simona, additional, Fenaux, Pierre, additional, Kantarjian, Hagop M., additional, Killick, Sally, additional, Mikkael, Sekeres A, additional, List, Alan F., additional, Komrokji, Rami S., additional, Tefferi, Ayalew, additional, Solary, Eric, additional, and Padron, Eric, additional

Published
2016
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103. Unusual meteorological phenomena: Vallombrosa forest windthrow caused by the storm of March 5th, 2015. Analyses and evaluations

Author

CIBECCHINI, DANIELE, AMINTI, GIOVANNI, ANTONELLO, LEONARDO, BRACALINI, MATTEO, CAMBI, MARTINA, CARRARI, ELISA, CROCI, FRANCESCO, ERRICO, ALESSANDRO, FODERI, CRISTIANO, FRASSINELLI, NICCOLO', GIAMBASTIANI, YAMUNA, GIANNETTI, FRANCESCA, IACOBELLI, SIMONA, LASCHI, ANDREA, RACANELLI, VERONICA, SASSOLI, MARTINA, and MIGLIORINI, DUCCIO

Subjects
Catastrophic meteorological events, Windstorm, Global change, Forest stability, Forest Management, Windthrows
Published
2015

105. Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors

Author

Styczyński, Jan, Tridello, Gloria, Koster, Linda, Iacobelli, Simona, van Biezen, Anja, van der Werf, Steffie, Mikulska, Małgorzata, Gil, Lidia, Cordonnier, Catherine, Ljungman, Per, Averbuch, Diana, Cesaro, Simone, de la Camara, Rafael, Baldomero, Helen, Bader, Peter, Basak, Grzegorz, Bonini, Chiara, Duarte, Rafael, Dufour, Carlo, Kuball, Jurgen, Lankester, Arjan, Montoto, Silvia, Nagler, Arnon, Snowden, John A., Kröger, Nicolaus, Mohty, Mohamad, and Gratwohl, Alois

Abstract

Information on incidence, and factors associated with mortality is a prerequisite to improve outcome after hematopoietic stem cell transplantation (HSCT). Therefore, 55′668 deaths in 114′491 patients with HSCT (83.7% allogeneic) for leukemia were investigated in a landmark analysis for causes of death at day 30 (very early), day 100 (early), at 1 year (intermediate) and at 5 years (late). Mortality from all causes decreased from cohort 1 (1980–2001) to cohort 2 (2002–2015) in all post-transplant phases after autologous HSCT. After allogeneic HSCT, mortality from infections, GVHD, and toxicity decreased up to 1 year, increased at 5 years; deaths from relapse increased in all post-transplant phases. Infections of unknown origin were the main cause of infectious deaths. Lethal bacterial and fungal infections decreased from cohort 1 to cohort 2, not unknown or mixed infections. Infectious deaths were associated with patient-, disease-, donor type, stem cell source, center, and country- related factors. Their impact varied over the post-transplant phases. Transplant centres have successfully managed to reduce death after HSCT in the early and intermediate post-transplant phases, and have identified risk factors. Late post-transplant care could be improved by focus on groups at risk and better identification of infections of “unknown origin”.

Published
2020
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106. Association of aplastic anaemia and lymphoma: a report from the severe aplastic anaemia working party of the European Society of Blood and Bone Marrow Transplantation.

Author

Rovó, Alicia, Kulasekararaj, Austin, Medinger, Michael, Chevallier, Patrice, Ribera, Jose M., Peffault de Latour, Regis, Knol, Cora, Iacobelli, Simona, Kanfer, Edward, Bruno, Benedetto, Maury, Sébastien, Quarello, Paola, Koh, Mickey B. C., Schouten, Harry, Blau, Igor W., Tichelli, André, Hill, Anita, Risitano, Antonio, Passweg, Jakob, and Marsh, Judith

Subjects
APLASTIC anemia, LYMPHOMAS, BONE marrow transplantation, ASSOCIATIONS, institutions, etc., CANCER treatment
Abstract

The article examines diseases characteristics as well as treating centre attitudes concerning the therapy and outcome of patients having aplastic anaemia and lymphoma. The evaluation was peformed by Severe Aplastic Anaemia Working Party of the European Society of Blood and Bone Marrow Transplantation.

Published
2019
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107. Impact of T‐cell depletion strategies on outcomes following hematopoietic stem cell transplantation for idiopathic aplastic anemia: A study on behalf of the European blood and marrow transplant severe aplastic anemia working party.

Author

Samarasinghe, Sujith, Clesham, Katherine, Iacobelli, Simona, Sbianchi, Giulia, Knol, Cora, Hamladji, Rose‐Marie, Socié, Gerard, Aljurf, Mahmoud, Koh, Mickey, Sengeloev, Henrik, Dalle, Jean‐Hugues, Robinson, Stephen, Van Lint, Maria Teresa, Halkes, Constantijn J. M., Beelen, Dietrich, Mufti, Ghulam J., Snowden, John, Blaise, Didier, de Latour, Regis Peffault, and Marsh, Judith

Published
2019
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108. Treosulfan Compared to Busulfan in Allogeneic Haematopoietic Stem Cell Transplantation for Myelofibrosis: A Registry-Based Study from the Chronic Malignancies Working Party of the EBMT

Author

Robin, Marie, Iacobelli, Simona, Passweg, Jakob R., Koster, Linda, Potter, Victoria, Wilson, Keith, Salmenniemi, Urpu, Dreger, Dr., von dem Borne, Peter, Snowden, John, Robinson, Stephen, Chiara Finazzi, Maria, Schroeder, Thomas, Collin, Matthew P., Eder, Matthias, Forcade, Edouard, Loschi, Michael, Bramanti, Stefania, Perez-Simon, Jose A., Czerw, Tomasz, Polverelli, Nicola, Drozd-Sokolowska, Joanna, Raj, Kavita, Hernandez Boluda, Juan Carlos, and McLornan, Donal P

Abstract

Background

Published
2023
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109. Salvage Transplant Versus CAR-T Cell Therapy for Relapsed Multiple Myeloma

Author

Gagelmann, Nico, Garderet, Laurent, Iacobelli, Simona, Koster, Linda, Carotti, Alessandra, Schönland, Stefan, Galieni, Piero, Daskalakis, Michael, Roeloffzen, Wilfried, Hunter, Hannah, Duchosal, Michel A., Lenhoff, Stig, Arat, Mutlu, Wulf, Gerald G., Bolam, Simon, Pastore, Domenico, Gedde-Dahl, Tobias, Richardson, Deborah Susan, Mielke, Stephan, Raj, Kavita, Drozd-Sokolowska, Joanna, Hayden, Patrick John, and McLornan, Donal P

Abstract

Background:Ide-cel and cilta-cel received regulatory approval for the treatment of patients with relapsed or refractory multiple myeloma (MM) after ≥4 prior lines of therapy, and almost all eligible patients in the US and Europe have previously received at least one autologous hematopoietic cell transplant (autoHCT). Even for those who received upfront autoHCT, salvage transplant (either second autoHCT or allogeneic HCT) for patients with relapsed MM was shown to be effective and feasible. Therefore, comparing CAR-T cell therapy with salvage transplant could facilitate future selection of patients with relapsed MM, as eligibility for transplant (especially allogeneic HCT) differs significantly from that of CAR-T.

Published
2023
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110. Comparison of Haematopoietic Stem Cell Transplantation Approaches in Primary Plasma Cell Leukaemia

Author

William Arcese, Keith Wilson, Linda Koster, Paolo Bartolomeo, Eefke Petersen, Jan J. Cornelissen, Patrice Chevallier, Nicolaus Kröger, Bruno Lioure, Curly Morris, Stig Lenhoff, Sarah Lawless, Xavier Poiré, Nicolaas Schaap, Reza Tabrizi, Roberto Foa, Laurent Garderet, Iacobelli Simona, Martin R. Schipperus, John A. Snowden, Didier Blaise, Stefan Schönland, Ghulam J. Mufti, Anja van Biezen, Nigel H. Russell, and Jürgen Finke

Subjects
Cancer Research, medicine.medical_specialty, Allogeneic transplantation, business.industry, medicine.medical_treatment, Hazard ratio, Immunology, Hematopoietic stem cell transplantation, Cell Biology, Hematology, Biochemistry, Transplantation, 03 medical and health sciences, 0302 clinical medicine, Autologous stem-cell transplantation, Oncology, Median follow-up, 030220 oncology & carcinogenesis, Internal medicine, medicine, Clinical endpoint, Progression-free survival, business, 030215 immunology
Abstract

Introduction Primary plasma cellleukemiais a rare and aggressive disorder. While autologous stem cell transplantation has been shown to improve outcome, response durations are short and further strategies are needed. Data is needed to help guide clinicians on the best approach to manage this disease. Therefore in an era of novel agents and improved autologous and allogeneic transplantation strategies this study compared different transplantation approaches in the treatment of PCL. Material and Methods A retrospective analysis was undertaken of theEuropean Group for Bone Marrow Transplantation (EBMT) experience of patients with primary PCL undergoing hematopoietic stem cell transplantation between 1998 and 2012. Only patients who had achieved complete response, partial response or stable disease prior to transplantation were included. Patients with progressive or relapsed disease were excluded. Data was collected using MED A and MED B forms. The primary end point was overall survival and data was analysed according to the information on the planned transplant strategy reported at the time of first transplant (intent-to-treat principle). Results A total of 460 patients were identified and categorised into 4 transplant groups. 1. One patient did not proceed to Allo 2. Four patients not classified The follow up period ranged from 1 to 208 months with a median follow up of 48.9 months. Patients undergoing allo upfront were found to have the worst overall survival. Compared to single auto this was statistically significant with a Hazard Ratio (HR) 1.85 (p=0.007). Compared to auto-allo the allo up front group had an even higher risk HR 3.18 (p=0.018). The double auto versus single auto had a HR 1.39 which was not statistically significant (p=0.28). The auto-allo compared to single auto has a time varying effect with a higher mortality at the beginning and better risk afterwards. The effect on average is not significant HR 0.58 (p=0.24). When we consider time varying effects three periods were examined, 0-12, 12-36 and 36-60 months. Allo upfront is still confirmed to be inferior to single auto and also to auto-allo in the first year. Auto-allo has a trend to superiority versus single or double auto in the mid-term. However due to lack of follow up data in the auto-allo group it is difficult to assess possible benefits of auto-allo in the long term as there are few patients still at risk. Our initial analysis does suggest an advantage. Preliminary analysis suggests that the auto-allo group enjoy the best progression free survival. The superiority of auto-allo versus allo upfront may be attributed to the higher rates of non-relapse related mortality observed in allo upfront. Conclusion Our preliminary work has demonstrated that allo upfront is associated with the worst overall survival. Further data is needed to reliably assess the outcome of auto-allo group which appears to be superior. Therefore we plan to request additional information from involved centres to strengthen the power of our results. Table Table. Disclosures Foà: Ariad: Speakers Bureau; Pfizer: Speakers Bureau; BMS: Consultancy; Celgene: Consultancy, Speakers Bureau; Amgen: Consultancy, Speakers Bureau; Gilead: Consultancy, Speakers Bureau; Janssen-Cilag: Consultancy, Speakers Bureau; Genetech: Consultancy; Roche: Consultancy, Speakers Bureau. Garderet:Takeda: Consultancy; Amgen: Consultancy; BMS: Consultancy, Honoraria; Novartis: Consultancy.

Published
2016

111. High-dose therapy and autologous stem cell transplantation in patients with POEMS syndrome: a retrospective study of the Plasma Cell Disorder sub-committee of the Chronic Malignancy Working Party of the European Society for Blood & Marrow Transplantation

Author

Cook, Gordon, primary, Iacobelli, Simona, additional, van Biezen, Anja, additional, Ziagkos, Dimitris, additional, LeBlond, Veronique, additional, Abraham, Julie, additional, McQuaker, Grant, additional, Schoenland, Stefan, additional, Rambaldi, Alessandro, additional, Halaburda, Kazimierz, additional, Rovira, Maria, additional, Sica, Simona, additional, Byrne, Jenny, additional, Sanz, Ramon Garcia, additional, Nagler, Arnon, additional, van de Donk, Niels W.C.J., additional, Sinisalo, Marjatta, additional, Cook, Mark, additional, Kröger, Nicolaus, additional, De Witte, Theo, additional, Morris, Curly, additional, and Garderet, Laurant, additional

Published
2016
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112. Impact of Donor Epstein-Barr Virus Serostatus on the Incidence of Graft-Versus-Host Disease in Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation: A Study From the Acute Leukemia and Infectious Diseases Working Parties of the European Society for Blood and Marrow Transplantation

Author

Styczynski, Jan, primary, Tridello, Gloria, additional, Gil, Lidia, additional, Ljungman, Per, additional, Hoek, Jennifer, additional, Iacobelli, Simona, additional, Ward, Katherine N., additional, Cordonnier, Catherine, additional, Einsele, Hermann, additional, Socie, Gerard, additional, Milpied, Noel, additional, Veelken, Hendrik, additional, Chevallier, Patrice, additional, Yakoub-Agha, Ibrahim, additional, Maertens, Johan, additional, Blaise, Didier, additional, Cornelissen, Jan, additional, Michallet, Mauricette, additional, Daguindau, Etienne, additional, Petersen, Eefke, additional, Passweg, Jakob, additional, Greinix, Hildegard, additional, Duarte, Rafael F., additional, Kröger, Nicolaus, additional, Dreger, Peter, additional, Mohty, Mohamad, additional, Nagler, Arnon, additional, and Cesaro, Simone, additional

Published
2016
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113. Very Good Response and Overall Survival after Allogeneic Stem Cell Transplantation in Patients with Systemic Light Chain Amyloidosis; Results of a Non-Interventional Study By the Plasma Cell Disorder Subcommittee of the Chronic Malignancy Working Party of the EBMT

Author

Schönland, Stefan, primary, Hegenbart, Ute, additional, Iacobelli, Simona, additional, Hoek, Jennifer, additional, Passweg, Jakob R., additional, Bordessoule, Dominique, additional, Bourhis, Jean-Henri, additional, Schipperus, Martin R., additional, deWitte, Theo, additional, Garderet, Laurent, additional, and Kröger, Nicolaus, additional

Published
2015
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114. Outcome of BONE Marrow Transplantation in Congenital Diskeratosis: Preliminary DATA from the European Group for BONE Marrow Transplantation (EBMT)

Author

Fioredda, Francesca, primary, Korthof, Elisabeth T, additional, Iacobelli, Simona, additional, Knol, Cora, additional, Veelken, Joan H, additional, Veys, Paul, additional, Yoshimi, Ayami, additional, Mellegren, Karin, additional, Fagioli, Franca, additional, Zecca, Marco, additional, Maschan, Alexey, additional, O'Brien, Tracey, additional, Diaz, Miguel Angel, additional, Smith, Owen, additional, Socie, Gerard, additional, Josue, de la Fuente, additional, Or, Reuven, additional, and Dufour, Carlo, additional

Published
2015
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115. Results of Allogeneic Transplantation As First Line Rescue Therapy in Patients with Multiple Myeloma Relapsing to a Prior Autograft: Role of Conditioning Regimen

Author

Perez-Simon, Jose A., primary, Marquez-Malaver, Francisco J, additional, Knol, Cora, additional, Iacobelli, Simona, additional, Blaise, Didier, additional, Milpied, Noel-Jean, additional, Meijer, Ellen, additional, Dreger, Peter, additional, Koc, Yener, additional, Petersen, Eefke, additional, Michallet, Mauricette, additional, Garderet, Laurent, additional, and Kroeger, Nicolaus, additional

Published
2015
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116. The EBMT Score Predicts Transplant Related Mortality and Overall Survival after Allogeneic Stem Cell Transplantation for Myelodysplastic Syndromes

Author

Lozano, Sara, primary, Olavarria, Eduardo, additional, Iacobelli, Simona, additional, van Biezen, Anja, additional, Beelen, Dietrich W., additional, Finke, Jurgen, additional, Mufti, Ghulam J, additional, Niederwieser, Dietger, additional, Ehninger, Gerhard, additional, Ganser, Arnold, additional, Stuhler, Gernot, additional, Maertens, Johan, additional, Bacigalupo, Andrea, additional, Volin, Liisa, additional, Nagler, Arnon, additional, Kobbe, Guido, additional, Schönland, Stefan, additional, de Witte, Theo, additional, Kröger, Nicolaus, additional, and Robin, Marie, additional

Published
2015
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117. Impact of Different In Vivo T Cell Depletion Strategies on Outcomes Following Hematopoietic Stem Cell Transplantation for Idiopathic Aplastic Anaemia: A Study on Behalf of the EBMT SAA Working Party

Author

Samarasinghe, Sujith, primary, Iacobelli, Simona, additional, Knol, Cora, additional, Hamladji, Rose-Marie, additional, Socie, Gerard, additional, Aljurf, Mahmoud, additional, Koh, Mickey, additional, Sengeloev, Henrik, additional, Dalle, Jean-Hugues, additional, Robinson, Stephen, additional, Bacigalupo, Andrea, additional, Veelken, Joan H, additional, Beelen, Dietrich, additional, Mufti, Ghulam J, additional, Snowden, John A, additional, Blaise, Didier, additional, Marsh, Judith C.W., additional, Dufour, Carlo, additional, and Risitano, Antonio M, additional

Published
2015
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120. Second Autologous Stem Cell Transplantation in Poor Stem Cell Mobilizers Multiple Myeloma Patients

Author

Sever, Matjaz, Sbianchi, Giulia, Iacobelli, Simona, van der Werf, Steffie, Wieslaw, Wiktor-Jedrzejczak, Blaise, Didier, Apperley, Jane F., Mohty, Mohamad, Scheid, Christof, Wilson, Keith, Russel, Nigel H, Kalhs, Peter, Chevallier, Patrice, Ringhoffer, Mark, Kobbe, Guido, Mayer, Jiri, Jost, Edgar, Zudaire, Teresa, Schiel, Xaver, Isaksson, Cecilia, Trneny, Marek, Schönland, Stefan, Morris, Curly, Garderet, Laurent, and Kroeger, Nicolaus

Published
2017
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121. Autoimmune Cytopenias (AIC) Following Allogeneic Haematopoietic Stem Cell Transplant for Acquired Aplastic Anaemia: A Joint Study of the Autoimmune Diseases and Severe Aplastic Anaemia Working Parties (ADWP/SAAWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Miller, Paul D E, Snowden, John A, Madrigal, J. Alejandro, Iacobelli, Simona, Eikema, Diderik-Jan, Knol, Cora, Marsh, Judith, Rice, Carmel, Koh, Mickey, Fagioli, Franca, Chaganti, Sridhar, Finke, Jürgen, Duarte, Rafael F, Bader, Peter, Passweg, Jakob R., Peffault De Latour, Regis, and Dufour, Carlo

Published
2017
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122. Allogeneic Hematopoietic Stem Cell Transplantation in Myelodysplastic Syndrome (MDS) Patients at Lower Risk According to International Prognostic Scoring System (IPSS) : A Retrospective Study on Behalf of the Cmwp of the EBMT

Author

Robin, Marie, primary, Raphael, Porcher, additional, van Biezen, Anja, additional, Volin, Liisa, additional, Mufti, Ghulam J., additional, Craddock, Charles, additional, Finke, Jurgen, additional, Richard Espiga, Carlos, additional, Passweg, Jakob, additional, Peniket, Andrew, additional, Maertens, Johan, additional, Sucak, Gulsan, additional, Gedde-Dahl, Tobias, additional, Vitek, Antonin, additional, Nagler, Arnon, additional, Blaise, Didier, additional, Beelen, Dietrich, additional, Maillard, Natacha, additional, Schwerdtfeger, Rainer, additional, Iacobelli, Simona, additional, de Witte, Theo, additional, and Kroeger, Nicolaus, additional

Published
2014
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123. Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma: Evolution and Outcomes over More Than Two Decades within EBMT Centers

Author

Michallet, Mauricette, primary, Sobh, Mohamad, additional, Iacobelli, Simona, additional, van Biezen, Anja, additional, Dreger, Peter, additional, Petersen, Eefke, additional, Schaap, Nicolaas PM, additional, Bandini, Giuseppe, additional, Volin, Liisa, additional, Meijer, Ellen, additional, Niederwieser, Dietger, additional, Einsele, Hermann, additional, Blaise, Didier, additional, Tabrizi, Reza, additional, Vincent, Laure, additional, Finke, Jurgen, additional, Bunjes, Donald, additional, Cornelissen, Jan J., additional, Gahrton, Gosta, additional, Garderet, Laurent, additional, and Kroger, Nicolaus, additional

Published
2014
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124. Reduced Intensity Vs. Standard Conditioning Followed By Allogeneic Stem Cell Transplantation for Patients with MDS or Secondary AML: A Prospective, Randomized Phase III Study of the Chronic Malignancies Working Party of the EBMT (RICMAC-Trial)

Author

Kröger, Nicolaus, primary, Brand, Ronald, additional, Niederwieser, Dietger, additional, Platzbecker, Uwe, additional, Hübel, Kai, additional, Weber, Thomas, additional, Robin, Marie, additional, Stelljes, Matthias, additional, Afanasiev, Boris V, additional, Heim, Dominik, additional, Lambertenghi Deliliers, Giorgio, additional, Onida, Francesco, additional, Dreger, Peter, additional, Pini, Massimo, additional, Guidi, Stefano, additional, Volin, Liisa, additional, Gramatzki, Martin, additional, Bethge, Wolfgang A., additional, Poire, Xavier, additional, Kobbe, Guido, additional, van Os, Marleen, additional, Iacobelli, Simona, additional, and de Witte, Theo, additional

Published
2014
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125. Allogeneic Stem Cell Transplantation in Myelodysplastic Syndrome; A More Favorable Outcome after Fludarabine and Treosulfan Conditioning. a Survey on Behalf of the Chronic Malignancies Working Party of the EBMT

Author

Shimoni, Avichai, primary, Nagler, Arnon, additional, Iacobelli, Simona, additional, van Biezen, Anja, additional, Beelen, Dietrich, additional, Mufti, Ghulam J., additional, Ciceri, Fabio, additional, Kanz, Lothar, additional, Volin, Liisa, additional, Richard, Carlos, additional, Blaise, Didier, additional, Ganser, Arnold, additional, Luft, Thomas, additional, Chevallier, Patrice, additional, Schwerdtfeger, Rainer, additional, de Witte, Theo, additional, Robin, Marie, additional, and Kröger, Nicolaus, additional

Published
2014
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126. Influence of Preexisting Invasive Aspergillosis on Allo-HSCT Outcome: A Retrospective EBMT Analysis from the Infectious Diseases and Acute Leukemia Working Parties

Author

Penack, Olaf, primary, Tridello, Gloria, additional, Hoek, Jeniffer, additional, Socie, Gerard, additional, Blaise, Didier, additional, Passweg, Jakob, additional, Chevallier, Patrice, additional, Craddock, Charles, additional, Milpied, Noel, additional, Veelken, Hendrik, additional, Maertens, Johan, additional, Ljungman, Per T., additional, Cornelissen, Jan J., additional, Thiebaut-Bertrand, Anne, additional, Lioure, Bruno, additional, Michallet, Mauricette, additional, Iacobelli, Simona, additional, Nagler, Arnon, additional, Mohty, Mohamad, additional, and Cesaro, Simone, additional

Published
2014
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127. Comparison of Haematopoietic Stem Cell Transplantation Approaches in Primary Plasma Cell Leukaemia

Author

Lawless, Sarah, Iacobelli, Simona, van Biezen, Anja, Koster, Linda, Chevallier, Patrice, Blaise, Didier, Foa, Roberto, Tabrizi, Reza, Schaap, N., Lenhoff, Stig, Russell, Nigel, Petersen, Eefke, Cornelissen, J.J., Di Bartolomeo, Paolo, Wilson, Keith, Dreger, Peter, Schipperus, M.R., Lioure, Bruno, Arcese, William, Mufti, G.J., Snowden, John, Finke, Jurgen, Morris, Curly, Garderet, Laurent, and Nicolaus Kroger

Published
2017
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129. Center Experience and Calendar Year Of Transplantation Strongly Influence Short Term Survival After Autologous Peripheral Blood Transplantation In 1315 Patients With Light Chain Amyloidosis: An EBMT Analysis

Author

Schonland, Stefan O, primary, Hegenbart, Ute, additional, Iacobelli, Simona, additional, Hoek, Jennifer, additional, Rovira, M, additional, van Imhoff, Guustaaf, additional, Bandini, G, additional, Mellqvist, Ulf-Henrik, additional, Leblond, Veronique, additional, Carlson, Kristina, additional, Zver, Samo, additional, Blaise, Didier, additional, Alessandrino, Emilio Paolo, additional, Garderet, Laurent, additional, and Kröger, Nicolaus, additional

Published
2013
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130. EBMT Prospective Non-Interventional Study On Allogeneic Hematopoietic Stem Cell Transplantation In T-Prolymphocytic Leukemia (T-PLL). Preliminary Analysis Of 43 Patients

Author

Jedrzejczak, Wieslaw Wiktor, primary, Iacobelli, Simona, additional, Hoek, Jennifer D.C., additional, Drozd-Sokolowska, Joanna E, additional, Potter, Michael, additional, Wulf, Gerald, additional, Chevallier, Patrice, additional, Ljungman, Per T., additional, Koc, Yener, additional, Schetelig, Johannes, additional, de Witte, Theo, additional, Kroeger, Nicolaus, additional, and Dreger, Peter, additional

Published
2013
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131. Reduced Intensity Allogeneic Stem Cell Transplant In Patients With Multiple Myeloma: A Comparison Of Planned Autologous-Reduced Intensity Allogeneic Stem Cell Transplant (Auto-Allo) and Reduced Intensity Allogeneic Stem Cell Transplant (RIC) As Upfront Transplant In Patients With Multiple Myeloma, An EBMT Analysis

Author

Sahebi, Firoozeh, primary, Iacobelli, Simona, additional, Van Biezen, Anja, additional, Volin, Liisa, additional, Dreger, Peter, additional, Michallet, Mauricette, additional, Ljungman, Per T., additional, Gahrton, Goesta, additional, Morris, Curly TCM, additional, Schonland, Stefan, additional, de Witte, Theo, additional, Garderet, Laurent, additional, Kroeger, Nicolaus, additional, Henseler, Anja, additional, Schaap, Nicolaas PM, additional, Caballero, D, additional, Poire, Xavier, additional, Passweg, Jakob, additional, and Hamljadi, Rose-Marie, additional

Published
2013
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132. The Role Of High Dose Chemotherapy and Autologous Stem Cell Transplantation (ASCT) In Patients With POEMS Syndrome: A Retrospective study Of The Plasma Cell Disorders Subcommittee Of The Chronic Malignancy Working Party Of The EBMT

Author

Cook, Gordon, primary, Garderet, Laurent, additional, Iacobelli, Simona, additional, Morris, Curly, additional, Kroeger, Nikolaus, additional, van Biezen, Anja, additional, Rovira, M, additional, Byrne, Jenny, additional, Bordessoule, Dominique, additional, Leone, Giuseppe, additional, Nagler, Arnon, additional, Cook, Mark, additional, Legros, Laurence, additional, Ossenkoppele, Gert J., additional, Sanz, R Gacria, additional, Hoek, Jennifer, additional, and Castagna, Luca, additional

Published
2013
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133. Comparison Of Intensive Chemotherapy and Hypomethylating Agents Prior To Allogeneic Stem Cell Transplantation For Advanced MDS (RAEB, RAEB-T). A Study Of The MDS Subcommittee Of The Cmwp Of EBMT

Author

Potter, Victoria T, primary, Iacobelli, Simona, additional, van Biezen, Anja, additional, Maertens, Johann, additional, Bourhis, Jean-Henri, additional, Passweg, Jakob R., additional, Yakhoub-Agha, I, additional, Tabrizi, Reza, additional, Bay, Jacques-Olivier, additional, Robin, Marie, additional, Chevallier, Patrice, additional, Chalandon, Yves, additional, Huynh, Anne, additional, de Witte, Theo, additional, and Kroeger, Nikolaus, additional

Published
2013
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134. Low tumor burden is associated with early B-cell reconstitution and is a predictor of favorable outcome after non-myeloablative stem cell transplant for chronic lymphocytic leukemia

Author

Hebenstreit, Karin, primary, Iacobelli, Simona, additional, Leiblein, Sabine, additional, Eisfeld, Ann-Kathrin, additional, Pfrepper, Christian, additional, Heyn, Simone, additional, Vucinic, Vladan, additional, Franke, Georg-Nikolaus, additional, Krahl, Rainer, additional, Fricke, Stephan, additional, Becker, Cornelia, additional, Pönisch, Wolfram, additional, Behre, Gerhard, additional, Niederwieser, Dietger, additional, and Lange, Thoralf, additional

Published
2013
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136. Response to Rituximab-Based Therapy and Risk Factor Analysis in Epstein Barr Virus–Related Lymphoproliferative Disorder After Hematopoietic Stem Cell Transplant in Children and Adults: A Study From the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation

Author

Styczynski, Jan, primary, Gil, Lidia, additional, Tridello, Gloria, additional, Ljungman, Per, additional, Donnelly, J. Peter, additional, van der Velden, Walter, additional, Omar, Hamdy, additional, Martino, Rodrigo, additional, Halkes, Constantijn, additional, Faraci, Maura, additional, Theunissen, Koen, additional, Kalwak, Krzysztof, additional, Hubacek, Petr, additional, Sica, Simona, additional, Nozzoli, Chiara, additional, Fagioli, Franca, additional, Matthes, Susanne, additional, Diaz, Miguel A., additional, Migliavacca, Maddalena, additional, Balduzzi, Adriana, additional, Tomaszewska, Agnieszka, additional, Camara, Rafael de la, additional, van Biezen, Anja, additional, Hoek, Jennifer, additional, Iacobelli, Simona, additional, Einsele, Hermann, additional, and Cesaro, Simone, additional

Published
2013
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137. Survival probabilities with time-dependent treatment indicator: quantities and non-parametric estimators.

Author

Bernasconi, Davide Paolo, Rebora, Paola, Iacobelli, Simona, Valsecchi, Maria Grazia, and Antolini, Laura

Abstract

The 'landmark' and 'Simon and Makuch' non-parametric estimators of the survival function are commonly used to contrast the survival experience of time-dependent treatment groups in applications such as stem cell transplant versus chemotherapy in leukemia. However, the theoretical survival functions corresponding to the second approach were not clearly defined in the literature, and the use of the 'Simon and Makuch' estimator was criticized in the biostatistical community. Here, we review the 'landmark' approach, showing that it focuses on the average survival of patients conditional on being failure free and on the treatment status assessed at the landmark time. We argue that the 'Simon and Makuch' approach represents counterfactual survival probabilities where treatment status is forced to be fixed: the patient is thought as under chemotherapy without possibility to switch treatment or as under transplant since the beginning of the follow-up. We argue that the 'Simon and Makuch' estimator leads to valid estimates only under the Markov assumption, which is however less likely to occur in practical applications. This motivates the development of a novel approach based on time rescaling, which leads to suitable estimates of the counterfactual probabilities in a semi-Markov process. The method is also extended to deal with a fixed landmark time of interest. [ABSTRACT FROM AUTHOR]

Published
2016
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138. Superiority of the Triple Combination of Bortezomib-Thalidomide-Dexamethasone Over the Dual Combination of Thalidomide-Dexamethasone in Patients With Multiple Myeloma Progressing or Relapsing After Autologous Transplantation: The MMVAR/IFM 2005-04 Randomized Phase III Trial From the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation

Author

Garderet, Laurent, primary, Iacobelli, Simona, additional, Moreau, Philippe, additional, Dib, Mamoun, additional, Lafon, Ingrid, additional, Niederwieser, Dietger, additional, Masszi, Tamas, additional, Fontan, Jean, additional, Michallet, Mauricette, additional, Gratwohl, Alois, additional, Milone, Giuseppe, additional, Doyen, Chantal, additional, Pegourie, Brigitte, additional, Hajek, Roman, additional, Casassus, Philippe, additional, Kolb, Brigitte, additional, Chaleteix, Carine, additional, Hertenstein, Bernd, additional, Onida, Francesco, additional, Ludwig, Heinz, additional, Ketterer, Nicolas, additional, Koenecke, Christian, additional, van Os, Marleen, additional, Mohty, Mohamad, additional, Cakana, Andrew, additional, Gorin, Norbert Claude, additional, de Witte, Theo, additional, Harousseau, Jean Luc, additional, Morris, Curly, additional, and Gahrton, Gösta, additional

Published
2012
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139. Kinetics of Engraftment and Predictors of Outcome in Patients with Advanced Chronic Lymphocytic Leukaemia (CLL) After Treatment with Low Dose Total Body Irradiation (TBI) Followed by related or unrelated hematopoietic Stem Cell Transplantation

Author

Hebenstreit, Karin, primary, Iacobelli, Simona, additional, Eisfeld, Ann-Kathrin, additional, Pfrepper, Christian, additional, Lange, Thoralf, additional, Krahl, Rainer, additional, Al-Ali, Haifa K., additional, Becker, Cornelia, additional, Pönisch, Wolfram, additional, Behre, Gerhard, additional, and Niederwieser, Dietger, additional

Published
2011
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140. Has Allogeneic Transplantation a Role in the Management of Plasma Cell Leukaemia? A Study on Behalf of the Myeloma Subcomittee of the Chronic Leukaemia Working Party of the EBMT

Author

Morris, Curly, primary, Iacobelli, Simona, additional, Gahrton, Gosta, additional, Garderet, Laurent, additional, Drake, Mary, additional, van Biezen, Anja, additional, Mohty, Mohamad, additional, Blaise, Didier, additional, Poiré, Xavier, additional, Kersten, Marie José, additional, Milpied, Noel-Jean, additional, Lenhoff, Stig, additional, Russell, Nigel H., additional, Finke, J.ürgen, additional, and de Witte, T. M., additional

Published
2011
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141. Risk Factors of Thromboembolic Events in Multiple Myeloma Treated with IMiDs-Based Therapy While on LMWH Prophylaxis,

Author

Leleu, Xavier, primary, Iacobelli, Simona, additional, Barrois, Alain, additional, Pelle, Benjamin, additional, Clark, Liz, additional, Boyle, Eileen, additional, Moreau, Philippe, additional, Dib, Mamoun, additional, Caillot, Denis, additional, Niederwieser, Dietger, additional, Masszi, Tamas, additional, Fontan, Jean, additional, Doyen, Chantal, additional, Hajek, Roman, additional, Onida, Francesco, additional, Ludwig, Heinz, additional, de Witte, Theo M., additional, Gahrton, Gosta, additional, Morris, Curly TCM, additional, and Garderet, Laurent, additional

Published
2011
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142. Tandem Autologous/Reduced-Intensity Conditioning Allogeneic Stem-Cell Transplantation Versus Autologous Transplantation in Myeloma: Long-Term Follow-Up

Author

Björkstrand, Bo, primary, Iacobelli, Simona, additional, Hegenbart, Ute, additional, Gruber, Astrid, additional, Greinix, Hildegard, additional, Volin, Liisa, additional, Narni, Franco, additional, Musto, Pellegrino, additional, Beksac, Meral, additional, Bosi, Alberto, additional, Milone, Giuseppe, additional, Corradini, Paolo, additional, Goldschmidt, Hartmut, additional, de Witte, Theo, additional, Morris, Curly, additional, Niederwieser, Dietger, additional, and Gahrton, Gösta, additional

Published
2011
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144. Tandem Autologous(ASCT)/ Allogeneic Reduced Intensity Conditioning Transplantation (RIC) with Identical Sibling Donor Versus ASCT in Previously Untreated Multiple Myeloma (MM): Long Term Follow up of a Prospective Controlled Trial by the EBMT.

Author

Gahrton, Gosta, primary, Bjorkstrand, Bo, additional, Iacobelli, Simona, additional, Hegenbart, Ute, additional, Gruber, Astrid, additional, Greinix, Hildegard, additional, Volin, Liisa, additional, Narni, Franco, additional, Musto, Pellegrino, additional, Beksac, Meral, additional, Bosi, Alberto, additional, Milone, Giuseppe, additional, Corradini, Paolo, additional, Goldschmidt, Hartmut, additional, de Witte, Theo, additional, Morris, Curly, additional, and Niederwieser, Dietger, additional

Published
2009
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145. Liposomal daunorubicinversusstandard daunorubicin: long term follow-up of the GIMEMA GSI 103 AMLE randomized trial in patients older than 60 years with acute myelogenous leukaemia

Author

Latagliata, Roberto, primary, Breccia, Massimo, additional, Fazi, Paola, additional, Iacobelli, Simona, additional, Martinelli, Giovanni, additional, Di Raimondo, Francesco, additional, Sborgia, Marco, additional, Fabbiano, Francesco, additional, Pirrotta, Maria Teresa, additional, Zaccaria, Alfonso, additional, Amadori, Sergio, additional, Caramatti, Cecilia, additional, Falzetti, Franca, additional, Candoni, Anna, additional, Mattei, Daniele, additional, Morselli, Monica, additional, Alimena, Giuliana, additional, Vignetti, Marco, additional, Baccarani, Michele, additional, and Mandelli, Franco, additional

Published
2008
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148. Efficacy and Outcome of Allogeneic Transplantation in IgD and Nonsecretory Myeloma. A Report on Behalf of the Myeloma Subcommittee of the Chronic Malignancies Working Party of the European Group for Blood and Marrow Transplantation.

Author

Morris, Curly, Iacobelli, Simona, Gahrton, Gösta, van Biezen, Anja, Drake, Mary, Garderet, Laurent, Potter, Michael, Schattenberg, Anton V., Cornelissen, Jan J., Hamladji, Rose-Marie, Martelli, Massimo, Petersen, Eefke, Rovira, Montserrat, Bandini, Giuseppe, Kroger, Nicolaus, and de Witte, Theo

Subjects
*HOMOGRAFTS, *TRANSPLANTATION of organs, tissues, etc., *MYELOMA proteins, *IMMUNOGLOBULIN idiotypes, *BONE marrow transplantation
Abstract

We have recently reported on the outcome of autologous transplantation in the rare myelomas (IgD, IgE, IgM, and nonsecretory [NS]) but there is no real information on the outcome of these conditions after allogeneic transplantation. We used the European Group for Blood and Marrow Transplantation myeloma database to compare the outcomes after allogeneic transplantation of 1354 common myelomas (IgG, IgA, and light chain myeloma) with the outcome in 26 IgD myelomas and 52 NS myelomas. There was little difference between common and the IgD and NS myeloma patients with respect to prognostic factors although the IgD group had a higher beta 2 microglobulin at diagnosis, shorter time to transplantation, and more T cell depletion. IgD and NS patients had a significantly greater achievement of complete remission at conditioning but this did not translate into equivalent progression-free survival and overall survival for the IgD patients although the NS outcome was very similar to that of common myeloma. The PFS and OS of IgD, common, and NS myelomas appear similar after allogeneic transplantation, despite a tendency for higher early relapse rate in IgD myeloma. Allogeneic transplantation may, therefore, be an option to investigate in prospective observational studies. [ABSTRACT FROM AUTHOR]

Published
2015
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149. Long Term Follow-Up of the Gimema GSI 103 AMLE Randomized Trial: Daunoxome Seems To Improve Disease-Free Survival (DFS) of Elderly Patients with Acute Myelogenous Leukemia (AML).

Author

Latagliata, Roberto, primary, Breccia, Massimo, additional, Iacobelli, Simona, additional, Fazi, Paola, additional, Martinelli, Giovanni, additional, Di Raimondo, Francesco, additional, Sborgia, Marco, additional, Fabbiano, Francesco, additional, Lauria, Francesco, additional, Zuffa, Eliana, additional, Venditti, Adriano, additional, Crugnola, Monica, additional, Peta, Antonio, additional, Candoni, Anna, additional, Cilloni, Daniela, additional, Mattei, Enrico, additional, Morselli, Monica, additional, Pastore, Domenico, additional, Adamo, Francesca, additional, Centra, Antonia, additional, Falzetti, Franca, additional, Vignetti, Marco, additional, Alimena, Giuliana, additional, and Mandelli, Franco, additional

Published
2006
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150. AML-M4: Role of Eosinophilia and Cytogenetics on Treatment Response and Survival. The GIMEMA Experience.

Author

Pulsoni, Alessandro, primary, Iacobelli, Simona, additional, Fazi, Paola, additional, Falcucci, Paolo, additional, Vignetti, Marco, additional, Tosti, Maria Elena, additional, Valentini, Giovanna Caterina, additional, Magrin, Silvana, additional, Ferrara, Felicetto, additional, Melillo, Lorella, additional, Di Raimondo, Francesco, additional, Sborgia, Marco, additional, Venditti, Adriano, additional, Camera, Andrea, additional, Liso, Vincenzo, additional, Specchia, Giorgina, additional, Leone, Giuseppe, additional, Mandelli, Franco, additional, Foa, Robert, additional, and Pagano, Livio, additional

Published
2005
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