101. P2-12 Recurrent denture related sores and oral cancer
- Author
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M.G. Haye Biazevic, J L Ferreira Antunes, Ligia Drovandi Braga Rotundo, Tatiana Natasha Toporcov, and M B de Carvalho
- Subjects
Mouth cancer ,Cancer prevention ,Epidemiology ,business.industry ,medicine.medical_treatment ,Dental prosthesis ,Public Health, Environmental and Occupational Health ,Case-control study ,Dentistry ,Cancer ,Logistic regression ,medicine.disease ,stomatognathic diseases ,medicine ,Health education ,Dentures ,business - Abstract
Background The potential contribution of denture-related sores to oral carcinogenesis still fuels controversies. This study assessed the association between recurrent denture-related sores and squamous cell carcinoma in anatomic sites of the mouth that are specifically at risk of sores by ill-fitting dentures. Methods We conducted a hospital-based case-control study comprising 71 histologically-confirmed cases of squamous cell carcinoma in anatomic sites of the mouth that were specifically at risk of developing sores due to ill-fitting dentures, who were attended at two hospitals in Sao Paulo, Brazil; and 240 controls without cancer, recruited from outpatient units of the same hospitals. Associations were assessed by multivariate logistic regression conditioned on socio-demographic (family income) and behavioural characteristics (tobacco smoking, alcohol drinking and dietary patterns). Results The association between ill-fitting dentures and mouth cancer was statistically significant in the multivariate model, which adjustment for socio-demographic and behavioural characteristics: OR=3.98 (95% CI 1.06 to 14.96). The specific assessment of association between tumours in the lower jaw and sores by mandibular dentures confirmed this result (OR=6.39; 95% CI 1.49 to 29.52). Conclusions These results reinforce the hypothesis that an appropriate application and monitoring of dental prosthesis represent a non-negligible scope for cancer prevention.
- Published
- 2011
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