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122 results on '"J. MILTON HARRIS"'

101. Phase Partitioning in Space and on Earth

Author

James M. Van Alstine, S. B. Bamberger, Laurel J. Karr, Peter A. Curreri, Helen C. Matsos, J. Milton Harris, John F. Boyce, D. E. Brooks, and Robert S. Snyder

Subjects
Surface tension, chemistry.chemical_classification, Electrophoresis, chemistry.chemical_compound, Aqueous solution, Membrane, chemistry, Chemical engineering, Phase (matter), Analytical chemistry, Polymer, Ethylene glycol, Macromolecule
Abstract

In aqueous solution at low concentrations, the neutral polymers dextran and poly(ethylene glycol) (PEG) rapidly form a two-phase system consisting of a PEG-rich phase floating on top of a dextran-rich phase. Biological particles and macromolecules tend to partition differentially between the phases and the liquid-liquid phase interface in these systems. Bioparticle partitioning has been shown to be related to physiologically important surface properties such as membrane charge or lipid composition.

Published
1987
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103. Nucleophilic Decontamination Agents

Author

J. Milton Harris

Subjects
Hydrolysis, Nucleophile, Chemistry, Organic chemistry, Ester hydrolysis, Reactivity (chemistry), Human decontamination, Solvent effects, Catalysis
Abstract

Work has primarily been concerned with an in-depth investigation of mustard reactions with hydroxylic solvents and other more powerful nucleophiles and, to a lesser extent, development of polyether-bound 'DFPase' and other catalysts for ester hydrolysis. The mustard work has led to a much better understanding of solvent effects on mustard reactivity and mustard reactions with nucleophiles. In the polyether work it was shown that PEGs dramatically facilitate solution and reaction of mustard and mustard simulants. Keywords: Decontamination materials.

Published
1989
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105. Cell separation by immunoaffinity partitioning with polyethylene glycol-modified protein A in aqueous polymer two-phase systems

Author

Steven G. Shafer, James M. Van Alstine, Laurel J. Karr, Robert S. Snyder, and J. Milton Harris

Subjects
Erythrocytes, Cell, macromolecular substances, Polyethylene glycol, Cell Separation, Biochemistry, Chromatography, Affinity, Analytical Chemistry, Polyethylene Glycols, chemistry.chemical_compound, Phase (matter), PEG ratio, medicine, Animals, Humans, Staphylococcal Protein A, chemistry.chemical_classification, Chromatography, Aqueous solution, biology, Chemistry, Immunochemistry, Organic Chemistry, technology, industry, and agriculture, General Medicine, Polymer, Red blood cell, medicine.anatomical_structure, Immunoglobulin G, biology.protein, Protein A
Abstract

Previous work has shown that polyethylene glycol (PEG)-bound antibodies can be used as affinity ligands in PEG-dextran two-phase systems to provide selective partitioning of cells to the PEG-rich phase. In the present work it is shown that immunoaffinity partitioning can be simplified by use of PEG-modified Protein A which complexes with unmodified antibody and cells and shifts their partitioning into the PEG-rich phase, thus eliminating the need to prepare a PEG-modified antibody for each cell type. In addition, the paper provides a more rigorous test of the original technique with PEG-bound antibodies by showing that it is effective at shifting the partitioning of either cell type of a mixture of two cell populations.

Published
1988

116. Tosylate/chloride rate ratios for beta-thioethyl substrates. Dimerization of 2-(methylthio)ethyl tosylate

Author

J. Milton Harris, M. Reza Sedaghat-Herati, and Samuel P. McManus

Subjects
Chemistry, Dimer, Organic Chemistry, Biochemistry, Chloride, Medicinal chemistry, chemistry.chemical_compound, Reaction rate constant, Sulfonate, Drug Discovery, medicine, Organic chemistry, Beta (finance), medicine.drug
Abstract

2-(Methylthio)ethyl tosylate undergoes facile dimerization. Previous OTs/Cl rate ratios were based on reaction of the tosylate dimer. New ratios, which are still low, are reported.

Published
1987
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118. Linear solvation energy relationships. Part 38. An analysis of the use of solvent parameters in the correlation of rate constants, with special reference to the solvolysis of t-butyl chloride

Author

Mortimer J. Kamlet, Ruth M. Doherty, J. Milton Harris, Michael H. Abraham, and Robert W. Taft

Subjects
Physics::Biological Physics, Quantitative Biology::Biomolecules, Chemistry, Solvation, Thermodynamics, Condensed Matter::Soft Condensed Matter, Solvent, Reaction rate constant, General equation, Organic chemistry, Butyl chloride, Solvolysis, Physics::Chemical Physics, Solvent effects, Cohesive energy
Abstract

Arguments are advanced to show that at least four solvent parameters are needed in any general equation for solvent effects on rate constants and on Gibbs energies of individual solutes: the parameters we use in our general equation are π*, the solvent dipolarity, α, the solvent hydrogen-bond acidity, β, the solvent hydrogen-bond basicity, and δH2, the solvent cohesive energy density. Parameters such as Y and N cannot represent unique solvent properties, because there exists more than one set of Y values and more than one set of N values. It is shown that the various Y values are ‘blends’ of π* and α in varying proportions, that the N values are ‘blends’ of π* and β, and that Y+ values are nearly pure β. Conditions for the collapse of the several Y scales into one scale, and for the collapse of the (mY+IN) equation into just mY, are outlined, based on the collinearity of π*, α, and β in certain sets of solvents.

Published
1987
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120. Nucleophilic substitution reactions at secondary carbon atoms. A modification of accepted views

Author

Douglas J. Raber and J. Milton Harris

Subjects
Substitution reaction, SNi, Reaction mechanism, Chemistry, Nucleophilic substitution, Organic chemistry, chemistry.chemical_element, SN2 reaction, General Chemistry, Ion pairs, Medicinal chemistry, Carbon, Education
Abstract

Considers reaction mechanisms that are intermediate between SN1 and SN2 and the possible role of ion pairs.

Published
1972
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121. Poly(ethylene Glycol)

Author

SAMUEL ZALIPSKY, J. MILTON HARRIS, Gunnar Karlström, Ola Engkvist, Danilo D. Lasic, Peter K. Working, Mary S. Newman, Judy Johnson, Joel B. Cornacoff, Martin C. Woodle, Y. Okumura, N. Higashi, V. Rosilio, J. Sunamoto, Sung Bum La, Yukio Nagasaki, Kazunori Kataoka, P. A. Mabrouk, Janice L. Panza, Keith E. LeJeune, Srikanth Venkatasubramanian, Alan J. Russell, Michael S. Hershfield, Merry R. Sherman, L. David Williams, Mark G. P. Saifer, John A. French, Larry W. Kwak, Joost J. Oppenheim, Kenneth Olson, Richard Gehant, Venkat Mukku, Kathy O'Connell, Brandon Tomlinson, Klara Totpal, Marjorie Winkler, Francesco M. Veronese, Paolo Caliceti, Oddone Schiavon, Irina N. Topchieva, Seth P. Monkarsh, Cheryl Spence, Jill E. Porter, Alicia Palleroni, Carlo Nalin, Perry Rosen, Pascal Bailon, Arthur M. Felix, George Barany, Fernando Albericio, Steven A. Kates, Maria Kempe, Andres Jäschke, Tatsuro Ouchi, Hidetoshi Kuroda, Yuichi Ohya, E. H. Schacht, K. Hoste, Sunitha Menon-Rudolph, Susan J. Sofia, Edward W. Merrill, Milan Mrksich, George M. Whitesides, Kazunori Em, SAMUEL ZALIPSKY, J. MILTON HARRIS, Gunnar Karlström, Ola Engkvist, Danilo D. Lasic, Peter K. Working, Mary S. Newman, Judy Johnson, Joel B. Cornacoff, Martin C. Woodle, Y. Okumura, N. Higashi, V. Rosilio, J. Sunamoto, Sung Bum La, Yukio Nagasaki, Kazunori Kataoka, P. A. Mabrouk, Janice L. Panza, Keith E. LeJeune, Srikanth Venkatasubramanian, Alan J. Russell, Michael S. Hershfield, Merry R. Sherman, L. David Williams, Mark G. P. Saifer, John A. French, Larry W. Kwak, Joost J. Oppenheim, Kenneth Olson, Richard Gehant, Venkat Mukku, Kathy O'Connell, Brandon Tomlinson, Klara Totpal, Marjorie Winkler, Francesco M. Veronese, Paolo Caliceti, Oddone Schiavon, Irina N. Topchieva, Seth P. Monkarsh, Cheryl Spence, Jill E. Porter, Alicia Palleroni, Carlo Nalin, Perry Rosen, Pascal Bailon, Arthur M. Felix, George Barany, Fernando Albericio, Steven A. Kates, Maria Kempe, Andres Jäschke, Tatsuro Ouchi, Hidetoshi Kuroda, Yuichi Ohya, E. H. Schacht, K. Hoste, Sunitha Menon-Rudolph, Susan J. Sofia, Edward W. Merrill, Milan Mrksich, George M. Whitesides, and Kazunori Em

Published
1997

122. Water-Soluble Polymers

Author

SHALABY W. SHALABY, CHARLES L. McCORMICK, GEORGE B. BUTLER, Nai Zheng Zhang, D. N. Schulz, Kishore R. Shah, D. Hunkeler, A. E. Hamielec, Luis C. Salazar, Stephen A. Ezzell, Choon H. Do, Y.-X. Zhang, A.-H. Da, Thieo E. Hogen-Esch, Sridhar Gopalkrishnan, William H. Daly, Soo Lee, Paul Ander, T. K. Wang, I. Iliopoulos, R. Audebert, Philip Molyneux, Howard G. Schild, Michael J. Mettille, Roger D. Hester, Mark D. Clark, Charles E. Hoyle, Curtis W. Frank, David J. Hemker, Hideko T. Oyama, Sarah E. Morgan, John C. Middleton, Dosha F. Cummins, Sau-Hung S. Leung, Joseph R. Robinson, William Regelson, Eberhard W. Neuse, Axel G. Perlwitz, J. Huguet, M. Boustta, M. Vert, J. Milton Harris, Julian M. Dust, R. Andrew McGill, Patricia A. Harris, Michael J. Edgell, Reza M. Sedaghat-Herati, Laurel J. Karr, Donna L. Donnelly, Paul A. Sandford, Arild Steinnes, John K. Borchardt, Waleed S. W. Shalaby, William E. Blevins, Kinam Park, Joan Feder-Davis, Daniel M. Hittner, Mary K. Cowman, SHALABY W. SHALABY, CHARLES L. McCORMICK, GEORGE B. BUTLER, Nai Zheng Zhang, D. N. Schulz, Kishore R. Shah, D. Hunkeler, A. E. Hamielec, Luis C. Salazar, Stephen A. Ezzell, Choon H. Do, Y.-X. Zhang, A.-H. Da, Thieo E. Hogen-Esch, Sridhar Gopalkrishnan, William H. Daly, Soo Lee, Paul Ander, T. K. Wang, I. Iliopoulos, R. Audebert, Philip Molyneux, Howard G. Schild, Michael J. Mettille, Roger D. Hester, Mark D. Clark, Charles E. Hoyle, Curtis W. Frank, David J. Hemker, Hideko T. Oyama, Sarah E. Morgan, John C. Middleton, Dosha F. Cummins, Sau-Hung S. Leung, Joseph R. Robinson, William Regelson, Eberhard W. Neuse, Axel G. Perlwitz, J. Huguet, M. Boustta, M. Vert, J. Milton Harris, Julian M. Dust, R. Andrew McGill, Patricia A. Harris, Michael J. Edgell, Reza M. Sedaghat-Herati, Laurel J. Karr, Donna L. Donnelly, Paul A. Sandford, Arild Steinnes, John K. Borchardt, Waleed S. W. Shalaby, William E. Blevins, Kinam Park, Joan Feder-Davis, Daniel M. Hittner, and Mary K. Cowman

Subjects
Water-soluble polymers--Congresses
Published
1991

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