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441 results on '"Jackson, Mark W."'

102. Pathogenesis of growth failure and partial reversal with gene therapy in murine and canine Glycogen Storage Disease type Ia

Author

Brooks, Elizabeth Drake, primary, Little, Dianne, additional, Arumugam, Ramamani, additional, Sun, Baodong, additional, Curtis, Sarah, additional, DeMaster, Amanda, additional, Maranzano, Michael, additional, Jackson, Mark W., additional, Kishnani, Priya, additional, Freemark, Michael S., additional, and Koeberl, Dwight D., additional

Published
2013
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106. Cancer Stem Cell Plasticity Drives Therapeutic Resistance.

Author

Doherty, Mary R., Smigiel, Jacob M., Junk, Damian J., and Jackson, Mark W.

Abstract

The connection between epithelial-mesenchymal (E-M) plasticity and cancer stem cell (CSC) properties has been paradigm-shifting, linking tumor cell invasion and metastasis with therapeutic recurrence. However, despite their importance, the molecular pathways involved in generating invasive, metastatic, and therapy-resistant CSCs remain poorly understood. The enrichment of cells with a mesenchymal/CSC phenotype following therapy has been interpreted in two different ways. The original interpretation posited that therapy kills non-CSCs while sparing pre-existing CSCs. However, evidence is emerging that suggests non-CSCs can be induced into a transient, drug-tolerant, CSC-like state by chemotherapy. The ability to transition between distinct cell states may be as critical for the survival of tumor cells following therapy as it is for metastatic progression. Therefore, inhibition of the pathways that promote E-M and CSC plasticity may suppress tumor recurrence following chemotherapy. Here, we review the emerging appreciation for how plasticity confers therapeutic resistance and tumor recurrence. [ABSTRACT FROM AUTHOR]

Published
2016
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112. Custom residential housing construction : a case study

Author

Jackson, Mark W. and Engineering

Abstract

This report is a synopsis of research conducted with Mickey Smith Professional Builders, Inc. (a successful custom home construction firm in Gainesville, Florida). The goal was to broaden my technical engineering knowledge and gain practical construction experience. The majority of time was spent developing a critical path construction schedule for a typical home. Although the schedule took a tremendous amount of time to develop, the results comprise only a few pages (Table 5.1 and Appendices A through D). To make the report more comprehensive, I covered the custom home construction business in general and provided insight into the steps required to build a custom home. Certain topics were brief or left out entirely to protect proprietary knowledge inherent to Mr. Smith's operation. To address this issue, I drafted the letter found in Section 6. 1. http://archive.org/details/customresidentia1094525797

Published
1994

137. Mapping, Measuring, and Modeling Urban Growth.

Author

Jensen, Ryan R., Gatrell, Jay D., McLean, Daniel, Hardin, Perry J., Jackson, Mark W., and Otterstrom, Samuel M.

Abstract

Immediately after World War II, developers in the United States took advantage of market demand and government incentives to build new housing subdivisions for returning soldiers anxious to marry, begin families, and resume civilian life. New developments such as Levittown (New York), Park Forest (Illinois) and Lakewood (California)1 sprang up and were quickly filled with affordable cookie-cutter homes for veterans seeking the American Dream of suburban home ownership (Hayden 2003). The baby boom followed. As a result of the boom and international immigration, the U.S. population grew from 151 million to 300 million between 1950 and 2007. To accommodate this expanding population growth, cities and towns in the U.S. rapidly spread into their rural hinterlands. [ABSTRACT FROM AUTHOR]

Published
2007
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138. Intraurban Population Estimation Using Remotely Sensed Imagery.

Author

Jensen, Ryan R., Gatrell, Jay D., McLean, Daniel, Hardin, Perry J., Jackson, Mark W., and Shumway, J. Matthew

Abstract

Of the Earth's 6.5 billion human inhabitants, nearly three billion live in urban settlements (UNCHS, 2001). Natural increase, land tenure practices, political policy, environmental degradation, and the dynamics of regional / global economics are largely responsible for the ongoing population shift from rural agrarian regions to cities. This increased urbanization is not just a developing country phenomenon. Urban areas of North America in 1900 were home to only 50% of the continent's population. In 2000, the percentage of North American urban inhabitants rose to 75%. [ABSTRACT FROM AUTHOR]

Published
2007
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149. Custom residential housing construction : a case study.

Author

Engineering, Jackson, Mark W., Engineering, and Jackson, Mark W.

Abstract

This report is a synopsis of research conducted with Mickey Smith Professional Builders, Inc. (a successful custom home construction firm in Gainesville, Florida). The goal was to broaden my technical engineering knowledge and gain practical construction experience. The majority of time was spent developing a critical path construction schedule for a typical home. Although the schedule took a tremendous amount of time to develop, the results comprise only a few pages (Table 5.1 and Appendices A through D). To make the report more comprehensive, I covered the custom home construction business in general and provided insight into the steps required to build a custom home. Certain topics were brief or left out entirely to protect proprietary knowledge inherent to Mr. Smith's operation. To address this issue, I drafted the letter found in Section 6. 1.

Published
1994

150. HiJAK'd Signaling; the STAT3 Paradox in Senescence and Cancer Progression.

Author

Junk, Damian J., Bryson, Benjamin L., and Jackson, Mark W.

Subjects
CARRIER proteins, CELLULAR aging, CELLULAR signal transduction, CYTOKINES, IMMUNE system, PROTEIN kinases, TUMORS, DISEASE progression
Abstract

Clinical and epidemiological data have associated chronic inflammation with cancer progression. Most tumors show evidence of infiltrating immune and inflammatory cells, and chronic inflammatory disorders are known to increase the overall risk of cancer development. While immune cells are often observed in early hyperplastic lesions in vivo, there remains debate over whether these immune cells and the cytokines they produce in the developing hyperplastic microenvironment act to inhibit or facilitate tumor development. The interleukin-6 (IL-6) family of cytokines, which includes IL-6 and oncostatin M (OSM), among others (LIF, CT-1, CNTF, and CLC), are secreted by immune cells, stromal cells, and epithelial cells, and regulate diverse biological processes. Each of the IL-6 family cytokines signals through a distinct receptor complex, yet each receptor complex uses a shared gp130 subunit, which is critical for signal transduction following cytokine binding. Activation of gp130 results in the activation of Signal Transducer and Activator of Transcription 3 (STAT3), and the Mitogen-Activated Protein Kinase (MAPK) and Phosphatidylinositol 3-Kinase (PI3K) signaling cascades. Tumor suppressive signaling can often be observed in normal cells following prolonged STAT3 activation. However, there is mounting evidence that the IL-6 family cytokines can contribute to later stages of tumor progression in many ways. Here we will review how the microenvironmental IL-6 family cytokine OSM influences each stage of the transformation process. We discuss the intrinsic adaptations a developing cancer cell must make in order to tolerate and circumvent OSM-mediated growth suppression, as well as the OSM effectors that are hijacked during tumor expansion and metastasis. We propose that combining current therapies with new ones that suppress the signals generated from the tumor microenvironment will significantly impact an oncologist's ability to treat cancer. [ABSTRACT FROM AUTHOR]

Published
2014
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