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This paper examines the factors responsible for changes in crude oil prices. The paper reviews the statistical behavior of oil prices, relates these to the predictions of theory, and looks in detail at key features of petroleum demand and supply. Topics discussed include the role of commodity speculation, OPEC, and resource depletion. The paper concludes that although scarcity rent made a negligible contribution to the price of oil in 1997, it may be an important feature of the most recent data.

Forestry is becoming more complex as a result of diverging societal demands. Indigenous Peoples' reconciliation and the challenges of climate change call for research that embraces transdisciplinarity, reciprocity, and problem-focused learning at the landscape scale. Both globally and in Canada, forestry and forest research are struggling to keep pace with this growing complexity. Place-based collaborative research and learning initiatives, described here as "learning landscapes," offer an under-explored approach to meeting diversifying goals for forest landscapes. We describe recent progress in Quesnel, British Columbia, where researchers and local institutions are engaging to strengthen resilience and innovation in the forest sector. We first define the concept of learning landscape in the context of transdisciplinary sustainability science, and then illustrate this approach using the case study of Quesnel. We describe a process of systems diagnosis, including asset mapping and analysis of potential forestry pathways through a "best bets" framework. We propose a Theory of Change as a way forward, outlining opportunities for government, industry, and communities in developing regional capacity for integrated management and high-value forest products. We reflect on the contributions of learning landscapes to knowledge generation, experiential learning, and institutional development, and discuss implications for steering decision-making in locally driven sustainability transitions. [ABSTRACT FROM AUTHOR]

Muscle-invasive bladder cancer (MIBC) is a potentially lethal disease. Here the authors characterize diverse genetic alterations in MIBC that convergently lead to constitutive activation of PPARgamma/RXRalpha and result in immunosurveillance escape by inhibiting CD8+ T-cell recruitment.

Long-range associations between enhancers and their target gene promoters have been shown to play critical roles in executing genome function. Recent variations of chromosome capture technology have revealed a comprehensive view of intra- and interchromosomal contacts between specific genomic sites. The locus control region of the β-globin genes (β-LCR) is a super-enhancer that is capable of activating all of the β-like globin genes within the locus in cis through physical interaction by forming DNA loops. CTCF helps to mediate loop formation between LCR-HS5 and 3'HS1 in the human β-globin locus, in this way thought to contribute to the formation of a "chromatin hub". The β-globin locus is also in close physical proximity to other erythrocyte-specific genes located long distances away on the same chromosome. In this case, erythrocyte-specific genes gather together at a shared "transcription factory" for co-transcription. Theoretically, enhancers could also activate target gene promoters at the identical loci, yet on different chromosomes in trans, a phenomenon originally described as transvection in Drosophilla. Although close physical proximity has been reported for the β-LCR and the β-like globin genes when integrated at the mouse homologous loci in trans, their structural and functional interactions were found to be rare, possibly because of a lack of suitable regulatory elements that might facilitate such trans interactions. Therefore, we re-evaluated presumptive transvection-like enhancer-promoter communication by introducing CTCF binding sites and erythrocyte-specific transcription units into both LCR-enhancer and β-promoter alleles, each inserted into the mouse ROSA26 locus on separate chromosomes. Following cross-mating of mice to place the two mutant loci at the identical chromosomal position and into active chromation in trans, their transcriptional output was evaluated. The results demonstrate that there was no significant functional association between the LCR and the β-globin gene in trans even in this idealized experimental context.

Interpreting discourses among implementers of what is termed a "landscape approach" enables us to learn from their experience to improve conservation and development outcomes. We use Q-methodology to explore the perspectives of a group of experts in the landscape approach, both from academic and implementation fields, on what hinderances are in place to the realisation of achieving sustainable landscape management in Indonesia. The results show that, at a generic level, "corruption" and "lack of transparency and accountability" rank as the greatest constraints on landscape functionality. Biophysical factors, such as topography and climate change, rank as the least constraining factors. When participants considered a landscape with which they were most familiar, the results changed: the rapid change of regulations, limited local human capacity and inaccessible data on economic risks increased, while the inadequacy of democratic institutions, "overlapping laws" and "corruption" decreased. The difference indicates some fine-tuning of generic perceptions to the local context and may also reflect different views on what is achievable for landscape approach practitioners. Overall, approximately 55% of variance is accounted for by five discourse factors for each trial. Four overlapped and two discourses were discrete enough to merit different discourse labels. We labelled the discourses (1) social exclusionists, (2) state view, (3) community view, (4) integrationists, (5) democrats, and (6) neoliberals. Each discourse contains elements actionable at the landscape scale, as well as exogenous issues that originate at national and global scales. Actionable elements that could contribute to improving governance included trust building, clarified resource rights and responsibilities, and inclusive representation in management. The landscape sustainability discourses studied here suggests that landscape approach "learners" must focus on ways to remedy poor governance if they are to achieve sustainability and multi-functionality.

This paper revisits the yield spread's usefulness for predicting future real GDP growth. We show that the contribution of the spread can be decomposed into the effect of expected future changes in short rates and the effect of the term premium. We find that both factors are relevant for predicting real GDP growth but the respective contributions differ. We investigate whether the cyclical behavior of interest rate volatility could account for either or both effects. We find that while volatility displays important correlations with both the term structure of interest rates and GDP, it does not appear to account for the yield spread's usefulness for predicting GDP growth.