101. The effects of allogenic stem cells in a murine model of hind limb diabetic ischemic tissue
- Author
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Jesús Álvarez García, Soledad García Gómez-Heras, Luis Riera del Moral, Carlota Largo, Damián García-Olmo, and Mariano García-Arranz
- Subjects
Limb ischemia ,Allogeneic stem cells ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background Diabetes is one of the major risk factors for peripheral arterial disease. In patients in whom surgery cannot be performed, cell therapy may be an alternative treatment. Since time is crucial for these patients, we propose the use of allogenic mesenchymal cells. Methods We obtained mesenchymal cells derived from the fat tissue of a healthy Sprague-Dawley rat. Previous diabetic induction with streptozotocin in 40 male Sprague-Dawley rats, ligation plus left iliac and femoral artery sections were performed as a previously described model of ischemia. After 10 days of follow-up, macroscopic and histo-pathological analysis was performed to evaluate angiogenic and inflammatory parameters in the repair of the injured limb. All samples were evaluated by the same blind researcher. Statistical analysis was performed using the SPSS v.11.5 program (P
- Published
- 2017
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