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103. Taxifolin‐mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of glucocorticoid‐induced osteonecrosis of the femoral head.

Author

Jiang, Hongyi, Lin, Chihao, Cai, Tingwen, Jiang, Liting, Lou, Chao, Lin, Shida, Wang, Weidan, Yan, Zijian, Pan, Xiaoyun, and Xue, Xinghe

Abstract

Glucocorticoid‐induced osteonecrosis of the femoral head (GIONFH) is the main complication secondary to long‐term or excessive use of glucocorticoids (GCs). Taxifolin (TAX) is a natural antioxidant with various pharmacological effects, such as antioxidative stress and antiapoptotic properties. The purpose of this study was to explore whether TAX could regulate oxidative stress and apoptosis in GIONFH by activating the nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway. We conducted qRT‐PCR, Western blotting, TUNEL assays, flow cytometry, and other experiments in vitro. Microcomputed tomography analysis, hematoxylin–eosin staining, and immunohistochemical staining were performed to determine the therapeutic effect of TAX in vivo. TAX mitigated the overexpression of ROS and NOX gene expression induced by DEX, effectively reducing oxidative stress. Additionally, TAX could alleviate DEX‐induced osteoblast apoptosis, as evidenced by qRT‐PCR, Western blotting, and other experimental techniques. Our in vivo studies further demonstrated that TAX mitigates the progression of GIONFH in rats by combating oxidative stress and apoptosis. Mechanistic exploration revealed that TAX thwarts the progression of GIONFH through the activation of the Nrf2 pathway. Overall, our research herein reports that TAX‐mediated Nrf2 activation ameliorates oxidative stress and apoptosis for the treatment of GIONFH. [ABSTRACT FROM AUTHOR]

Published
2024
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110. Effect of Na+ and Sr2+ Substitution on the Formation of the Oxygen Vacancies in Y3Al2Ga3O12:Ce3+ Phosphor.

Author

Yang, Ting, Jiang, Hongyi, Dong, Ye, Gao, Shuai, and Liu, Shuning

Abstract

The low-valence cations Na+ and Sr2+ were selected as the co-dopants to increase the vacancies concentration in the Y2.982Ce0.018Al2Ga3O12 phosphor. The successful incorporation of Na+ and Sr2+ was confirmed by the X-Ray Diffraction (XRD) results. All the samples show 5d-4f green persistent luminescence of Ce3+ after 450 nm excitation. The decay curves demonstrate that the persistent luminescence is effectively enhanced with Na+ and Sr2+ doping. The thermoluminescence glow curves also show not only does the trap concentration increase, but also the distribution of trap depths is broadened. In addition, the air- and H2/Ar-annealing treatments were conducted on every as-made sample. The experimental results prove that the increased traps after the Na+/Sr2+ doping are mainly attributed to the oxygen vacancies, and the traps have a continuous and broad distribution of trap depths. We hope this work could give new inspiration for designing a high-performance persistent phosphor. [ABSTRACT FROM AUTHOR]

Published
2023
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111. Supplementary Figure Legends 1-6 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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112. Supplementary Movie 1 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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113. Supplementary Figure 2 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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114. Supplementary Figure 3 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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115. Supplementary Figure 4 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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116. Supplementary Procedures from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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117. Supplementary Figure 5 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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118. Supplementary Figure 6 from Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound

Author

Xuan, Jim W., primary, Bygrave, Michael, primary, Jiang, Hongyi, primary, Valiyeva, Fatma, primary, Dunmore-Buyze, Joy, primary, Holdsworth, David W., primary, Izawa, Jonathan I., primary, Bauman, Glenn, primary, Moussa, Madeleine, primary, Winter, Scott F., primary, Greenberg, Norman M., primary, Chin, Joseph L., primary, Drangova, Maria, primary, Fenster, Aaron, primary, and Lacefield, James C., primary

Published
2023
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135. Supplementary document for Tuning the persistent luminescence property of Y3Al2Ga3O12:Ce3+,Yb3+ phosphor by controlling the intrinsic oxygen vacancy concentration - 6056742.pdf

Author

Yang, Ting, Jiang, Hongyi, Dong, Ye, Liu, Shuning, and Gao, Shuai

Abstract

PLE and PL spectra, PersL decay curves, and TL spectra of the YAGG:Ce annealed in air and H2/Ar; PersL spectra of the YAGG:Ce,Yb annealed in air and H2/Ar measured at 1, 5, and 10 min after excitation; Comparison of the normalized PersL spectra and P

Published
2022
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