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Emerging findings from studies with infants at familial high risk for autism spectrum disorder (ASD), owing to an older sibling with a diagnosis, suggest that those who go on to develop ASD show early impairments in the processing of stimuli with both social and non-social content. Although ASD is defined by social-communication impairments and restricted and repetitive behaviours, the majority of cognitive theories of ASD posit a single underlying factor, which over development has secondary effects across domains. This is the first high-risk study to statistically differentiate theoretical models of the development of ASD in high-risk siblings using multiple risk factors. We examined the prediction of ASD outcome by attention to social and non-social stimuli: gaze following and attentional disengagement assessed at 13 months in low-risk controls and high-risk ASD infants (who were subsequently diagnosed with ASD at 3 years). When included in the same regression model, these 13-month measures independently predicted ASD outcome at 3 years of age. The data were best described by an additive model, suggesting that non-social attention, disengagement, and social attention as evidenced by gaze following, have a cumulative impact on ASD risk. These data argue against cognitive theories of ASD which propose that a single underlying factor has cascading effects across early development leading to an ASD outcome, and support multiple impairment models of ASD that are more consistent with recent genetic and neurobiological evidence. [Members of the BASIS Team who also contributed to the writing of this article are as follows: Simon Baron-Cohen, Patrick Bolton, Susie Chandler, Janice Fernandes, Holly Garwood, Kristelle Hudry, Greg Pasco, Leslie Tucker, and Agnes Volein.]

The recent development in the measurements of spontaneous mental state understanding, employing eye-movements instead of verbal responses, has opened new opportunities for understanding the developmental origin of "mind-reading" impairments frequently described in autism spectrum disorders (ASDs). Our main aim was to characterize the relationship between mental state understanding and the broader autism phenotype, early in childhood. An eye-tracker was used to capture anticipatory looking as a measure of false beliefs attribution in 3-year-old children with a family history of autism (at-risk participants, n 47) and controls (control participants, n 39). Unlike controls, the at-risk group, independent of their clinical outcome (ASD, broader autism phenotype or typically developing), performed at chance. Performance was not related to children's verbal or general IQ, nor was it explained by children "missing out" on crucial information, as shown by an analysis of visual scanning during the task. We conclude that difficulties with using mental state understanding for action prediction may be an endophenotype of autism spectrum disorders.

Socioeconomic status (SES) impacts on both structural and functional brain development in childhood, but how early its effects can be demonstrated is unknown. In this study we measured resting baseline EEG activity in the gamma frequency range in awake 6-9-month-olds from areas of East London with high socioeconomic deprivation. Between-subject comparisons of infants from low-and high-income families revealed significantly lower frontal gamma power in infants from low-income homes. Similar power differences were found when comparing infants according to maternal occupation, with lower occupational status groups yielding lower power. Infant sleep, maternal education, length of gestation, and birth weight, as well as smoke exposure and bilingualism, did not explain these differences. Our results show that the effects of socioeconomic disparities on brain activity can already be detected in early infancy, potentially pointing to very early risk for language and attention difficulties. This is the first study to reveal region-selective differences in functional brain development associated with early infancy in low-income families.

In this study, 4-month-old infants' and adults' spontaneous preferences for emotional and neutral displays with direct and averted gaze are investigated using visual preference paradigms. Specifically, by presenting two approach-oriented emotions (happiness and anger) and two avoidance-oriented emotions (fear and sadness), we asked whether the pattern of emotion-gaze interaction suggested by the shared signal hypothesis (SSH) would also be found with this paradigm. Both age groups demonstrated an ability to discern the approach- and avoidance-oriented emotions, matching them with direct and averted gaze, respectively. Nonetheless, infants showed a greater sensitivity for the congruent emotion-gaze combination in the approach-oriented emotions, while adults were equally sensitive to the gaze-expression congruence for both the approach- and avoidance-oriented emotions. In a follow-up experiment, infants showed no preference for direct or averted gaze in the context of neutral faces. We conclude that the SSH may have validity from infancy, gradually extending from approach-oriented emotions to avoidance-oriented emotions over the course of development. (Contains 3 tables and 3 figures.)

The current study investigated the role of cultural norms on the development of face-scanning. British and Japanese adults' eye movements were recorded while they observed avatar faces moving their mouth, and then their eyes toward or away from the participants. British participants fixated more on the mouth, which contrasts with Japanese participants fixating mainly on the eyes. Moreover, eye fixations of British participants were less affected by the gaze shift of the avatar than Japanese participants, who shifted their fixation to the corresponding direction of the avatar's gaze. Results are consistent with the Western cultural norms that value the maintenance of eye contact, and the Eastern cultural norms that require flexible use of eye contact and gaze aversion. (Contains 4 figures.)

Previous research into face processing in autism spectrum disorder (ASD) has revealed atypical biases toward particular facial information during identity recognition. Specifically, a focus on features (or high spatial frequencies [HSFs]) has been reported for both face and nonface processing in ASD. The current study investigated the development of spatial frequency biases in face recognition in children and adolescents with and without ASD, using nonverbal mental age to assess changes in biases over developmental time. Using this measure, the control group showed a gradual specialization over time toward middle spatial frequencies (MSFs), which are thought to provide the optimal information for face recognition in adults. By contrast, individuals with ASD did not show a bias to one spatial frequency band at any stage of development. These data suggest that the "midband bias" emerges through increasing face-specific experience and that atypical face recognition performance may be related to reduced specialization toward optimal spatial frequencies in ASD.

Previous research has suggested that a mid-band of spatial frequencies is critical to face recognition in adults, but few studies have explored the development of this bias in children. We present a paradigm adapted from the adult literature to test spatial frequency biases throughout development. Faces were presented on a screen with particular spatial frequencies blocked out by noise masks. A mid-band bias was found in adults and 9- and 10-year-olds for upright faces but not for inverted faces, suggesting a face-sensitive effect. However, 7- and 8-year-olds did not demonstrate the mid-band bias for upright faces but rather processed upright and inverted faces similarly. This suggests that specialization toward the mid-band for upright face recognition develops gradually during childhood and may relate to an advanced level of face expertise. (Contains 2 figures.)

Knowledge about the functional status of the frontal cortex in infancy is limited. This study investigated the effects of polymorphisms in four dopamine system genes on performance in a task developed to assess such functioning, the Freeze-Frame task, at 9 months of age. Polymorphisms in the catechol-O-methyltransferase ("COMT") and the dopamine D4 receptor ("DRD4") genes are likely to impact directly on the functioning of the frontal cortex, whereas polymorphisms in the dopamine D2 receptor ("DRD2") and dopamine transporter ("DAT1") genes might influence frontal cortex functioning indirectly via strong frontostriatal connections. A significant effect of the "COMT" valine[superscript 158]methionine (Val[superscript 158]Met) polymorphism was found. Infants with the Met/Met genotype were significantly less distractible than infants with the Val/Val genotype in Freeze-Frame trials presenting an engaging central stimulus. In addition, there was an interaction with the "DAT1" 3[prime] variable number of tandem repeats polymorphism; the "COMT" effect was present only in infants who did not have two copies of the "DAT1" 10-repeat allele. These findings indicate that dopaminergic polymorphisms affect selective aspects of attention as early as infancy and further validate the Freeze-Frame task as a frontal cortex task. (Contains 1 footnote, 2 tables and 1 figure.)

We measured looking times and ERPs to examine the cognitive and brain bases of perceptual category learning in 6-month-old infants. In Experiment 1, we showed that categorization and exemplar discrimination rely on different cortical processes. Specifically, the repetition of individual exemplars resulted in differential cortical processing at posterior channels at an early stage during object processing (100-300 msec), whereas discriminating among members of different categories was reflected in ERP differences over anterior cortical regions occurring later in time (300-500 msec) than the repetition effects. In Experiment 2, replicating the findings of Study 1, we found that infants engage the same cortical processes to categorize visual objects into basic-level categories, regardless of whether a basic (bird vs. fish) or global level is crossed (birds vs. cars). This pattern of findings is consistent with perceptual accounts of infant categorization [Quinn, P. C., & Eimas, P. D. "Perceptual organization and categorization in young infants." In C. Rovee-Collier & L. P. Lipsitt (Eds.), "Advances in infancy research" (pp. 1-36). Norwood, NJ: Ablex, 1996] and accords with recent adult neural-level models of perceptual categorization.

We report a cross-syndrome comparison of the development of holistic processing in face recognition in school-aged children with developmental disorders: autism, Down syndrome, and Williams syndrome. The autism group was split into two groups: one with high-functioning children and one with low-functioning children. The latter group has rarely been studied in this context. The four disorder groups were compared with typically developing children. Cross-sectional trajectory analyses were used to compare development in a modified version of Tanaka and Farah's part-whole task. Trajectories were constructed linking part-whole performance either to chronological age or to several measures of mental age (receptive vocabulary, visuospatial construction, and the Benton Facial Recognition Test). In addition to variable delays in onset and rate of development, we found an atypical profile in all disorder groups. These profiles were atypical in different ways, indicating multiple pathways to, and variable outcomes in, the development of face recognition. We discuss the implications for theories of face recognition in both atypical and typical development, including the idea that part-whole and rotation manipulations may tap different aspects of holistic and/or configural processing. (Contains 5 figures and 3 tables.)

The authors review a viewpoint on human functional brain development, interactive specialization (IS), and its application to the emerging network of cortical regions referred to as the "social brain." They advance the IS view in 2 new ways. First, they extend IS into a domain to which it has not previously been applied--the emergence of social cognition and mentalizing computations in the brain. Second, they extend the implications of the IS view from the emergence of specialized functions within a cortical region to a focus on how different cortical regions with complementary functions become orchestrated into networks during human postnatal development. (Contains 3 figures.)

In four experiments, we investigated whether 9-month-old infants are sensitive to the relationship between gaze direction and object location and whether this sensitivity depends on the presence of communicative cues like eye contact. Infants observed a face, which repeatedly shifted its eyes either toward, or away from, unpredictably appearing objects. We found that they looked longer at the face when the gaze shifts were congruent with the location of the object. A second experiment ruled out that this effect was simply due to spatial congruency, while a third and a fourth experiment revealed that a preceding period of eye contact is required to elicit the gaze-object congruency effect. These results indicate that infants at this age can encode eye direction in referential terms in the presence of communication cues and are biased to attend to scenes with object-directed gaze. (Contains 2 figures.)

Human infants readily interpret the actions of others in terms of goals, but the origins of this important cognitive skill are keenly debated. We tested whether infants recognize others' actions as goal-directed on the basis of their experience with carrying out and observing goal-directed actions, or whether their perception of a goal-directed action is based on the recognition of a specific event structure. Counterintuitively, but consistent with our prediction, we observed that infants appear to extend goal attribution even to biomechanically impossible actions so long as they are physically efficient, indicating that the notion of "goal" is unlikely to be derived directly from infants' experience.

Neuroconstructivism is a theoretical framework focusing on the construction of representations in the developing brain. Cognitive development is explained as emerging from the experience-dependent development of neural structures supporting mental representations. Neural development occurs in the context of multiple interacting constraints acting on different levels, from the individual cell to the external environment of the developing child. Cognitive development can thus be understood as a trajectory originating from the constraints on the underlying neural structures. This perspective offers an integrated view of normal and abnormal development as well as of development and adult processing, and it stands apart from traditional cognitive approaches in taking seriously the constraints on cognition inherent to the substrate that delivers it.

We investigated newborns' sensitivity to the direction of gaze of another's face by using a preferential looking technique. This study extends earlier work on a preference for faces with direct gaze in newborns. In Experiment 1, we replicate the basic finding of Farroni and colleagues that newborns prefer to look at faces with direct gaze. In Experiments 2 and 3, we establish that a preference for faces with direct gaze in newborns is present only within the context of an upright face and a straight head, suggesting that relatively primitive configuration-sensitive mechanisms may be operating. Overall, these results further the view that relatively simple perceptual biases in newborns may be an essential foundation for later social-cognitive development.

Links between brain function measures and quality of parent-child interactions within the early developmental period have been investigated in typical and atypical development. We examined such links in a group of 104 infants with and without a family history for autism in the first year of life. Our findings suggest robust associations between event related potential responses to eye gaze and observed parent-infant interaction measures. In both groups, infants with more positive affect exhibit stronger differentiation to gaze stimuli. This association was observed with the earlier P100 waveform component in the control group but with the later P400 component in infants at-risk. These exploratory findings are critical in paving the way for a better understanding of how infant laboratory measures may relate to overt behavior and how both can be combined in the context of predicting risk or clinical diagnosis in toddlerhood. Keywords Infant * Autism * Interaction * EEG * Familial risk * Prospective study, Introduction In recent years, several studies on autism have investigated possible early behavioural markers of the disorder. As yet, a behavioural diagnosis is rarely made before the child reaches the [...]

The EEG reflects the activation of large populations of neurons that act in synchrony and propagate to the scalp surface. This activity reflects both the brain's background electrical activity and when the brain is being challenged by a task. Despite strong theoretical and methodological arguments for the use of EEG in understanding the neural correlates of autism, the practice of collecting, processing and evaluating EEG data is complex. Scientists should take into consideration both the nature of development in autism given the life-long, pervasive course of the disorder and the disability of altered or atypical social, communicative, and motor behaviors, all of which require accommodations to traditional EEG environments and paradigms. This paper presents guidelines for the recording, analyzing, and interpreting of EEG data with participants with autism. The goal is to articulate a set of scientific standards as well as methodological considerations that will increase the general field's understanding of EEG methods, provide support for collaborative projects, and contribute to the evaluation of results and conclusions. Keywords EEG * Electrophysiology * ERP * Event-related potentials * MEG * Magnetoencephalography * Autism * ASD * Guidelines, Scalp electrophysiological recordings are a non-invasive method of recording the brain's electrical activity. The methodology can be used across the lifespan (birth to old age) and with participants who have [...]

Eye gaze has been shown to be an effective cue for directing attention in adults. Whether this ability operates from birth is unknown. Three experiments were carried out with 2- to 5-day-old newborns. The first experiment replicated the previous finding that newborns are able to discriminate between direct and averted gaze, and extended this finding from real to schematic faces. In Experiments 2 and 3 newborns were faster to make saccades to peripheral targets cued by the direction of eye movement of a central schematic face, but only when the motion of the pupils was visible. These results suggest that newborns may show a rudimentary form of gaze following. (Contains 3 tables and 4 figures.)