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The thermal decomposition behavior of multi-walled carbon nanotubes (MWCNTs) was revisited to prepare partially opened MWCNTs by a simple air oxidation method which allows mass-productivity. As a promising matrix for sulfur cathodes, the partially opened MWCNTs can incorporate sulfur in hidden internal areas in the carbon nanotubes, leading to a homogeneous distribution through the MWCNT matrix. The resulting materials enable Li–S batteries to exhibit greatly enhanced electrochemical performance.

This study explored the role the musical industry plays in creating city brand images. The results showed that younger consumers were found to have more favorable visit intentions in New York and London due to their image as musical cities. Instagram users wanted to visit New York, but Twitter users had negative visit intentions in New York. Sensation-seeking orientation toward musicals influenced visit intention in New York. Broadway familiarity was linked to visit intention. In London, only sensation-seeking orientation influenced visit intention. Uses of SNS did not influence London visit intention and West End familiarity was not related to London visit intention. These results could provide academic and managerial implications for city branding.

We aimed to investigate the potential of preoperative mammographic breast density (MBD) as a prognostic factor in breast cancer. Data of 969 patients with primary breast cancer were analyzed. We defined low MBD as fatty or fibroglandular breast, and high MBD as heterogeneously dense or extremely dense breast, respectively. The high MBD group demonstrated a superior overall survival rate compared to the low MBD group (p 50 years (p 2 (p 50 years and the HRc(+)/HER2(−) subtype. Favorable clinicopathologic features, active treatments, and other factors could contribute to this causality.

Recently developed approaches in deterministic assembly allow for controlled, geometric transformation of two-dimensional structures into complex, engineered three-dimensional layouts. Attractive features include applicability to wide ranging layout designs and dimensions along with the capacity to integrate planar thin film materials and device layouts. The work reported here establishes further capabilities for directly embedding high-performance electronic devices into the resultant 3D constructs based on silicon nanomembranes (Si NMs) as the active materials in custom devices or microscale components released from commercial wafer sources. Systematic experimental studies and theoretical analysis illustrate the key ideas through varied 3D architectures, from interconnected bridges and coils to extended chiral structures, each of which embed n-channel Si NM MOSFETs (nMOS), Si NM diodes, and p-channel silicon MOSFETs (pMOS). Examples in stretchable/deformable systems highlight additional features of these platforms. These strategies are immediately applicable to other wide-ranging classes of materials and device technologies that can be rendered in two-dimensional layouts, from systems for energy storage, to photovoltaics, optoelectronics, and others.

Hydrocephalus is a common and costly neurological condition caused by the overproduction and/or impaired resorption of cerebrospinal fluid (CSF). The current standard of care, ventricular catheters (shunts), is prone to failure, which can result in nonspecific symptoms such as headaches, dizziness, and nausea. Current diagnostic tools for shunt failure such as computed tomography (CT), magnetic resonance imaging (MRI), radionuclide shunt patency studies (RSPSs), and ice pack–mediated thermodilution have disadvantages including high cost, poor accuracy, inconvenience, and safety concerns. Here, we developed and tested a noninvasive, skin-mounted, wearable measurement platform that incorporates arrays of thermal sensors and actuators for precise, continuous, or intermittent measurements of flow through subdermal shunts, without the drawbacks of other methods. Systematic theoretical and experimental benchtop studies demonstrate high performance across a range of practical operating conditions. Advanced electronics designs serve as the basis of a wireless embodiment for continuous monitoring based on rechargeable batteries and data transmission using Bluetooth protocols. Clinical studies involving five patients validate the sensor’s ability to detect the presence of CSF flow ( P = 0.012) and further distinguish between baseline flow, diminished flow, and distal shunt failure. Last, we demonstrate processing algorithms to translate measured data into quantitative flow rate. The sensor designs, fabrication schemes, wireless architectures, and patient trials reported here represent an advance in hydrocephalus diagnostics with ability to visualize flow in a simple, user-friendly mode, accessible to the physician and patient alike.

Despite the increasing use of alternative analgesic agents, salicylate overdose remains a not-uncommon problem. Severe poisoning is life threatening, so prompt treatment and supportive measures are required to reduce mortality. Generally, salicylate intoxication results in the development of high-anion-gap metabolic acidosis. However, outside of Korea, normal-anion-gap or negative-anion-gap metabolic acidosis with hyperchloremia is rarely reported. We report herein the case of an 83-year-old female patient with chronic aspirin intake who presented with hyperchloremia and a negative anion gap. The patient’s symptoms improved with conservative treatment and hemodialysis; notably, her chloride levels decreased as her blood salicylate concentrations decreased. Salicylate may cause hyperchloremia, demonstrating the importance of careful documentation of patient medication histories. (Korean J Med 2015;89:457-460)

Integrated log management system can help to predict the risk of security and contributes to improve the security level of the organization, and leads to prepare an appropriate security policy. In this paper, we have designed and implemented a Hadoop-based log analysis system by using distributed database model which can store large amount of data and reduce analysis time by automating log collecting procedure. In the proposed system, we use the HBase in order to store a large amount of data efficiently in the scale-out fashion and propose an easy data storing scheme for analysing data using a Hadoop-based normal expression, which results in improving data processing speed compared to the existing system.

Low modulus, compliant systems of sensors, circuits and radios designed to intimately interface with the soft tissues of the human body are of growing interest, due to their emerging applications in continuous, clinical-quality health monitors and advanced, bioelectronic therapeutics. Although recent research establishes various materials and mechanics concepts for such technologies, all existing approaches involve simple, two-dimensional (2D) layouts in the constituent micro-components and interconnects. Here we introduce concepts in three-dimensional (3D) architectures that bypass important engineering constraints and performance limitations set by traditional, 2D designs. Specifically, open-mesh, 3D interconnect networks of helical microcoils formed by deterministic compressive buckling establish the basis for systems that can offer exceptional low modulus, elastic mechanics, in compact geometries, with active components and sophisticated levels of functionality. Coupled mechanical and electrical design approaches enable layout optimization, assembly processes and encapsulation schemes to yield 3D configurations that satisfy requirements in demanding, complex systems, such as wireless, skin-compatible electronic sensors., Many low modulus systems, such as sensors, circuits and radios, are in 2D formats that interface with soft human tissue in order to form health monitors or bioelectronic therapeutics. Here the authors produce 3D architectures, which bypass engineering constraints and performance limitations experienced by their 2D counterparts.

The aims of this study were to determine the malignancy rate of probably benign lesions that show an interval change on follow-up ultrasound and to evaluate the differences seen on imaging between benign and malignant lesions initially categorized as probably benign but with interval change on follow-up breast ultrasound. We retrospectively reviewed 11,323 lesions from ultrasound-guided core-biopsies performed between June 2004 and December 2014 and identified 289 lesions (266 patients) with an interval change from probably benign (Breast Imaging Reporting and Data System [BI-RADS] category 3) in the previous 2 years. Malignancy rates were compared according to the ultrasound findings and the characteristics of the interval changes, including changes in morphology and/or diameter. The malignancy rate for probably benign lesions that showed an interval change on follow-up ultrasound was 6.9% (20/289). The malignancy rate was higher for clustered cysts (33.3%) and irregular or noncircumscribed masses (12.7%) than for circumscribed oval masses (5%) or complicated cysts (5%) seen on initial ultrasound (P = 0.043). Fifty-five percent of the malignancies were found to be ductal carcinoma in situ and there was 1 case of lymph node metastasis among the patients with invasive disease in whom biopsy was delayed by 6 to 15 months. The extent of invasiveness was greater in missed cases. There was a significant difference in the maximal diameter change between the 20 malignant lesions and the 269 benign lesions (4.0 mm vs 2.7 mm, P = 0.002). The cutoff value for maximal diameter change per initial diameter was 39.0% for predicting malignancy (sensitivity 95%, specificity 53.5%). The malignancy rate for morphologically changed lesions was significantly higher than for morphologically stable lesions (13.6% vs 4.9%; P = 0.024) Our 6.9% of probably benign lesions that showed an interval change finally turned out to be malignancy was mostly DCIS. The sonographic features, interval changes in sonographic features, and lesion size might help in the recategorization of these lesions.

Purpose We investigated B-cell lymphoma 2 (BCL2) regulation across DNA, RNA, protein, and methylation status according to molecular subtype of breast cancer using The Cancer Genome Atlas (TCGA) database. Materials and Methods We analyzed clinical and biological data on 1,096 breast cancers from the TCGA database. Biological data included reverse phase protein array (RPPA), mRNA sequencing (mRNA-seq), mRNA microarray, methylation, copy number alteration linear, copy number alteration nonlinear, and mutation data. Results The luminal A and luminal B subtypes showed upregulated expression of RPPA and mRNAseq and hypomethylation compared to the human epidermal growth factor receptor 2 (HER2) and triple-negative subtypes (all p < 0.001). No mutations were found in any subjects. High mRNA-seq and high RPPA were strongly associated with positive estrogen receptor, positive progesterone receptor (all p < 0.001), and negative HER2 (p < 0.001 and p=0.002, respectively). Correlation analysis revealed a strong positive correlation between protein and mRNA levels and a strong negative correlation between methylation and protein and mRNA levels (all p < 0.001). The high BCL2 group showed superior overall survival compared to the low BCL2 group (p=0.006). Conclusion The regulation of BCL2 was mainly associated with methylation across the molecular subtypes of breast cancer, and luminal A and luminal B subtypes showed upregulated expression of BCL2 protein, mRNA, and hypomethylation. Although copy number alteration may have played a minor role, mutation status was not related to BCL2 regulation. Upregulation of BCL2 was associated with superior prognosis than downregulation of BCL2.

This study explores the impacts of webtoons as branded entertainment on consumer responses in competitive advertising markets. A webtoon is a digital cartoon format developed in South Korea for Korean audience that do not read comic books often, but are heavy consumers of webtoons. Using general surveys on brand webtoons in Korea, factors influencing consumer attitudes and electronic word-of-mouth (eWOM) intentions were investigated. The results of this study found that there are hierarchical influences on the use of brand webtoons on consumer emotion, transportation, persuasion knowledge, and advertising believability in order. The pattern of relationships was somewhat different between effects on attitudes toward brand webtoons and eWOM intentions. More specifically, pleasure and arousal influenced both attitudes and eWOM intentions. However, dominance only influenced eWOM intentions, and transportation only influenced attitudes towards branded webtoons. Persuasion knowledge negatively influenced both dependent variables. Advertising believability showed positive influences on attitudes and behavioral intentions.

Aortoesophageal fistula (AEF) is an extremely rare but lethal cause of massive gastrointestinal hemorrhage. Characteristic symptoms are mid-thoracic pain, sentinel minor hemorrhage, and massive hemorrhage after a symptom-free interval. Prompt diagnosis and immediate treatments are necessary to reduce mortality. However, AEF is difficult to diagnose because it is uncommon and often leads to death with massive bleeding before proper evaluation. We report a case of endoscopic diagnosis of AEF that did not present with hematemesis; it was treated with thoracic endovascular aortic repair (TEVAR) and surgery. A 71-year-old female presented to the emergency department with epigastric discomfort. Endoscopy demonstrated a submucosal tumor-like protrusion and pulsating mass with blood clots. Contrast-enhanced chest CT confirmed AEF due to descending thoracic aortic aneurysm. The patient immediately underwent TEVAR to prevent massive bleeding and subsequently underwent surgery. Endoscopists should consider AEF if they see a submucosal tumor-like mass with a central ulcerative lesion or a pulsating protrusion covered with blood clots in mid-esophagus during an endoscopy.

To evaluate the value of the computer-aided diagnosis (CAD) program applied to diagnostic breast ultrasonography (US) based on operator experience.US images of 100 breast masses from 91 women over 2 months (from May to June 2015) were collected and retrospectively analyzed. Three less experi

'상하관계 갈등요인', '업무보상·평가요인', '감정노동 요인', '물리적 환경요인', '고용안정성', '심리적 직무요구요인', '의사결정 및 책임요인', '업무복잡성 요인', '업무경계 갈등요인', 그리고 '신체적 직무요구요인' 등 11개 요인, 46개 문항으로 구성된 사서를 위한 직무스트레스 척도가 개발되었다. ABSTRACT The purpose of this study is to develop a job-stress scale for librarians who work in university libraries. The study was first conducted by analyzing existing representative job-stress scales that are used domestically and internationally. To understand the characteristic of particular job stress that academic librarians have, the in-depth interview among qualitative research methods was selected, and 15 librarians who work at a 4-year system university libraries participated in this study. Based on the results of the questionnaire survey, the reliability and validity were verified. To analyze the validity, exploratory factor analysis was carried out. To extract factors, principal component analysis was used. To extract factors, principal component analysis was used. For the rotation method, a varimax rotation was applied. A tertiary measurement tool with a total of 46 questions for 11 factors was developed after removing measurement questions that were rejected as a result of the analysis. As a result of factor analysis on the tertiary measurement tool, 11 factors were extracted. Those 11 factors include 'peer relation conflict factor(factor 1)', 'superior-subordinate relation conflict factor (factor 2)', 'work compensation evaluation factor(factor 3)', 'emotional labor factor(factor 4)', 'physical environmental factor(factor 5)', 'employment stability(factor 6)', 'job demand factor(psychological) (factor 7)', 'decision-making and responsibility factor(factor 8)', 'work complexity factor(factor 9)', 'work boundary conflict factor(factor 10)', and 'job demand factor(physical)(factor 11)'.

The aim of this study was to investigate the follow-up results and characteristics of oval circumscribed lesions with fast initial enhancement on preoperative magnetic resonance imaging (MRI) in patients with newly diagnosed breast cancer. Preoperative data from consecutive patients newly diagnosed with breast cancer between 2010 and 2013 were retrospectively reviewed. Only MRI reports containing, “oval shape, circumscribed margin, and fast initial enhancement,” were extracted and analyzed. Follow-up results and clinical and pathological findings were evaluated. A total of 430 oval circumscribed lesions with fast initial enhancement were included. Forty-eight lesions were pathologically confirmed at initial workup and 382 were followed up. Among the 48 lesions, 14 were found to have additional malignancy and 34 were benign. Among the 382 followed-up lesions, only 1 was subsequently confirmed to be malignant. There were no evident changes in any of the remaining lesions during follow-up. The overall rate of malignancy was 3.5% (15/430). When lesions exhibited delayed washout enhancing kinetics (P

This paper considers the rockfall problems around the Seated Seokgayeorae Image at the UNESCO World Heritage site in Korea. Using the Barton-Bandis (BB) model in Universal Distinct Element Code (UDEC), quantitative information on the detachment of the loose boulders was obtained. Based on the result of the field survey and laboratory tests, key parameters for rockfall simulation were determined, and then back analysis was performed to calibrate the parameters for the study site. The maximum run-out distances, bounce heights, kinetic energies and translational velocities of falling boulders were simulated using RocFall 4.0 to assess the rockfall hazard around the Seated Seokgayeorae Image to ensure both the stability of the bas-relief and the safety of tourists. The results of the analyses showed that about 80% of falling boulders in a range of 100–150 kg pass the altar with an average speed of 8.4 m/s and that the maximum kinetic energy of the falling boulders is 12.5 kJ if the boulders hit the head of the statue. Therefore, the removal of loose blocks and trees on the upper outcrop and limited rock bolting were suggested for the reduction of rockfall risk.

An efficient method for release of ferulic acid from sweet potato stems was developed. Ferulic acid along with phenolic compounds were released from stems by acid and alkaline treatments. The base hydrolysis with 0.1 N NaOH yielded the highest quantity of total extracts (471.1 mg/g). The stems released more phenolic compounds when 0.0125∼0.025 N NaOH was employed. Where as ferulic acid release was maximal with 0.05 N H2SO4 (0.32 mg/g). Ferulic acid was separated from phenolics by column chromatography. Among the elution solvents, ethyl acetate fractions (80%) contained ferulic acid. Ethyl acetate eluants were further fractionated with n-hexane/ethyl acetate/formic acid (100/50/0.5, v/v/v). All fractions showed ferulic acid and phenolic compounds. Fraction V among them was ascribed to ferulic acid with an yield of 5.41 mg/g of dry sweet potato tissue.

To help address the physical, chemical, and biological degradation of agricultural soils resulting from indiscriminate use of chemical fertilizers, we developed a slow-release fertilizer from waste paper and urea. This approach has the advantage of a slow-release fertilizer in that it avoids surface runoff or leaching of nutrients, while providing an excellent medium for the recycling of waste paper. The successful impregnation of urea into waste paper was confirmed by scanning electron microscopy. This study also evaluated the release patterns of N from impregnated waste paper using a simulated soil solution and distilled water as leaching solutions. The release patterns of N were examined in both static and continuous-flow conditions for 720 h. Release of N from impregnated waste paper was found to be slow and steady, although the release rate of N was lower in distilled water than soil solution under both conditions.

This study carried out to elucidate the synthesis of MCPP–LDH hybrid, release pattern of MCPP from MCPP–LDH hybrid and their properties. MCPP–LDH hybrid was synthesized from MCPP and Mg–Al complex. Release pattern of MCPP from MCPP–LDH hybrid was slower in distilled water and soil solution but it was slower in distilled water than soil solution. MCPP–LDH hybrid has shown more stable condition than CO 3 2 - form of LDH in thermal and acidic condition. Therefore, MCPP–LDH hybrid would lead as functional and benign pesticide to minimize the harmful effects on soil environment by bulk herbicides.

24 patients underwent bilateral hip replacement, using the SROM modular system (Depuy Johnson & Johnson, MA, USA) with the porous-coated sleeve in one hip and an HA-coated sleeve in the other. 20 patients were followed for at least 4 years with clinical and radiographic evaluations. We found no difference between the two sides as regards the time of disappearance of thigh pain and hip scores. Radiographs showed a buttress sign in 18 HA-coated and 15 porous coated stems. There were no differences in the serial bone-remodeling pattern around the proximal sleeve and measurement of wear volume between the two groups. In the short- to medium-term, our findings support the view that the hydroxyapatite-coated femoral stem has no advantages over those with porous coating.

This study investigated the production of insoluble dietary fiber using forest waste, the dietary effect of manufactured insoluble fiber on physiological function in rat fed high cholesterol diets. Insoluble dietary fiber was prepared from the wood chips of oak (Quercus mongolica). The best condition for steam-explosion treatment for the preparation of insoluble dietary fiber was 25 kg/㎤ pressure for 6 minutes. In the chemical analysis of insoluble dietary fiber pretreated by 1% sodium hydroxide solution with steam-exploded wood, α-cellulose content was 61.7% in the insoluble dietary fiber, which contained 7.6% residual lignin. In order to compare insoluble dietary fiber with commercial α-cellulose of physiological function, Sprague-Dawley male rats weighing 100±10 g were randomly assigned to one normal diet, five high cholesterol diet containing 1% cholesterol. The high cholesterol diet groups were classified as fiber free diet (FF group), 5% commercial α-cellulose diet (5C group), 10% commercial α-cellulose (10C group), 5% insoluble dietary fiber diet (5M group),, 10% insoluble dietary fiber (10M group). The rats were fed ad libidum for 4 weeks. Food intake, weights gain,, food efficiency ratio in high cholesterol groups were higher than those of normal group, but there were no significant differences between the experimental groups. There were not any significant differences in the weights of liver, kidney,, small intestine of insoluble dietary fiber supplemented groups, but weight of cecum in all insoluble dietary fiber group were significantly higher than those of FF group. A gastrointestinal transit time was decreased by supplementation of insoluble dietary fiber. Weight, water contents of feces in the insoluble dietary fiber supplemented groups were significantly higher than those of the FF group. There were not any significant differences in the activities of the glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT) between the experimental groups. In conclusion, the manufactured insoluble dietary fiber, commercial insoluble fiber have the same physiological effects. The preparation method of the insoluble dietary fiber from the oak chips suited its purpose.

Background : By combining with technology, the recent KakaoTalk profile pictures have emerged as a communication method that expresses oneself in Cyberspace. As people’s desire to communicate through smart phones is increasing more and more, it has become more important to understand psychological and subjective attributes such as using types, use behavior, pursuing values, motivation for use and satisfaction of KakaoTalk profile image users. Methods : This paper adopted Q methodology for communication attributes from the perspective of humans" subjective inclinations, which are consumers/users. It discussed how KakaoTalk profile images are accepted as a new communication method, and what kind of meaning they have in Cyberspace in terms of the design; a typological analysis was also examined. Especially, the subjective standpoint, which can be called inner experience of humans, was analyzed as an approach to study symbolic interactionism and subjective areas of humans. Results : The analysis utilizing Q methodology identifies five self-types: The first one is called "Reality-reflecting Type" (those who express their status or job in detail and prefer pictures described in detail); the second one is called "Idea-expressive Type" (those who focus on background images of nature or abstract aspects rather than images of real objects); the third one is called "Character-creating Type" (those who create their own images according to the situation and regard the creating process as a cathartic experience); the next one is called "Mirror-reflecting Type" (those who emphasize expressive life and recreate their own images by adjusting to the situation); The final one is called "Satisfaction-faking Type" (those who focus on reality-escaping or reality-exaggerating images by recreating their situation with ironical expressions). Conclusion : The identity that users want to express in online virtual spaces through virtual existence like KakaoTalk profile images is, in many ways, their appearance that they desire to actualize in real life. In conclusion, the KakaoTalk profile images in Cyberspace are characterized as being plural and fluid. In other words, they have technical limitations; however, within the limits, they express the identity that each individual aims for in Cyberspace freely and specifically.

Lymphotoxin beta receptor (LTBR) is essential for development and organization of the secondary lymphoid tissues. To investigate whether LTBR polymorphisms are associated with IgA nephropathy (IgAN) in Korean children, One hundred ninety nine patients with IgAN and 289 controls were recruited. Two promoter single nucleotide polymorphisms (SNPs) (rs3759333, -1387C/T and rs3759334, -1326A/G) and one coding SNP (rs2364480, Ala172Ala) in LTBR gene were selected and genotyped by direct sequencing. For analysis of data, SNPStats, SPSS 18.0, and Haploview version 4.2 were used. Multiple logistic regression models (codominant 1, codominant 2, dominant, and recessive models) were performed for odds ratio (OR), 95% confidence interval (CI), and p value. The rs3759334 was significantly associated with IgAN in codominant 1 (G/G vs. A/G, p = 0.025) and dominant (p = 0.017) models. The A alleles of rs3759334 and rs2364480 were related to risk of developing IgAN, respectively (rs3759334, p = 0.015; rs2364480, p = 0.041). Haplotypes CGC and TAA in LTBR gene were also associated with IgAN, respectively (CGC, p = 0.032 in codominant; TAA, p = 0.008 in codominant, p = 0.009 in dominant models). In conclusion, results suggest that LTBR gene polymorphisms may be associated with risk of IgAN in Korean children.

The aim of this study was to investigate whether par-3 partitioning defective 3 homolog (C. elegans) (PARD3) single nucleotide polymorphisms (SNPs) are associated with schizophrenia. A total of 204 Korean schizophrenic patients [117 male, 41.1±9.6 years (mean age ± SD); 87 female, 42.6±11.5] and 351 control subjects (170 male, 43.8±6.6 years; 181 female, 44.2±5.8) were enrolled. We genotyped nine SNPs of the PARD3 gene [rs7075263 (intron), rs10827392 (intron), rs773970 (intron), rs2252655 (intron), rs10763984 (intron), rs3781128 (Ser889Ser), rs1936429 (intron), rs671228 (intron) and rs16935163 (intron)]. Genotypes of PARD3 polymorphisms were evaluated by direct sequencing. We used SNPStats, SPSS 18.0 and Haploview 4.2 software for analysis of genetic data. Multiple logistic regression models were used to calculate the odds ratio (OR), 95% confidence interval (CI), and corresponding p-values (p), controlling for age and gender as covariables. Allele frequencies of the PARD3 SNPs were significantly associated with schizophrenia (rs3781128, p=0.041; rs1936429, p=0.030; rs671228, p=0.028). Certain genotype frequencies of the PARD3 SNPs also showed significant associations with schizophrenia (p

12 Background: To evaluate the characteristics and malignancy rate of oval, circumscribed enhancing lesions seen on preoperative breast MRI in patients with breast cancer. Methods: From January 2010 through May 2013, a total number of 502 oval, circumscribed mass was incidentally found in 326 patients with breast cancer who had undergone preoperative breast MRI. Seventy-eight lesions were excluded due to the lack of follow-up imaging or total mastectomy. Biopsy was performed when suspicious enhancing kinetics or interval change were detected on MRI. Otherwise, MRI or ultrasound follow up for correlated lesion were performed at least 2 years. Clinical and imaging features were recorded for analysis. Results: Of the 424 oval, circumscribed enhancing lesions detected on MRI, twelve (2.8%) were malignant and 412 (97.2%) were benign. There was no significant difference in size between malignant (0.72±0.26 cm) and benign (0.71±0.34 cm) lesions (p = 0.932). Among 424 lesions, 43 lesions (10.1%) were pathologically confirmed and twelve were malignant. Positive predictive value (PPV) of malignancy for the biopsy was 27.9%. Among 12 malignant lesions, 7 (58.3%) were invasive ductal carcinoma, 4 (33.3%) were ductal carcinoma in situ, and 1 (8.3%) was tubular carcinoma. Of the pathologically confirmed benign lesions, 8 (25.8%) were fibroadenoma, 7 (22.6%) were intraductal papilloma. Interestingly, there were significantly frequent MRI features with early fast enhancement and delayed washout pattern in malignant (11/12) compared to benign (29/412) lesions (p < 0.001). PPV of malignancy for early fast enhancement and delayed washout pattern in MRI was 27.5%. Conclusions: Cancer yield in patients with oval, circumscribed enhancing lesion on preoperative breast MRI was 12 (2.8%) of 424. MRI features with early fast enhancement and delayed washout pattern strongly suggested malignancy.

Ankylosing spondylitis (AS) is a chronic inflammatory disease of the axial skeleton with involvement of peripheral joints and non-articular structures (1). Indeed, it is best known for its symptom of lower back pain; however, patients often present with hip or groin pain misleading the clinician to think that the cause lies primarily in the hips. Hip involvement as a common problem in AS increases the burden and negative affects its prognosis of AS than any other axial joints (2). Femoroacetabular impingement (FAI) has been recently identified as a major cause of early primary osteoarthritis (OA) of the hip (3). FAI refers to abnormal contact between the femoral head-neck junction or the acetabular rim (4). A number of predisposing conditions have been described with deformities of the femur and the acetabulum which result in FAI including Legg-Calve-Perthes, slipped capital femoral epiphysis, coxa magna, hip dysplasia, and fractures of the femoral neck (5). Though FAI has not been recognized as a common radiologic feature of AS, we noticed FAI like features in hips of AS patients and hypothesized that AS may be predisposed to FAI. To the best of our knowledge, there has been no study about FAI patHip Morphometry of Femoroacetabular Impingement Pattern in Patients with Ankylosing Spondylitis 강직성척추염 환자에서 대퇴비구충돌증후군 고관절 모양에 관한 연구

This study investigated the effect of a manufactured soluble dietary fiber on lipid metabolism in rats fed high cholesterol diets. Soluble dietary fiber was prepared from wood chips of oak (Quercus mongolica). Male Sprague-Dawley rats weighing 100 +/- 10 g were randomly assigned to either a normal diet or five high cholesterol diets containing 1% cholesterol and different fiber supplements. The high cholesterol groups were subdivided into fiber-free diet (FF), 5% pectin (5P), 10% pectin (10P), 5% manufactured soluble dietary fiber (5QM), and 10% manufactured soluble dietary fiber (10QM) groups. Total serum cholesterol concentrations in all soluble dietary fiber-supplemented groups were lower than in the FF group. The high-density lipoprotein-cholesterol concentration in the FF group was significantly lower, compared with the normal group, but was increased in groups supplemented with soluble dietary fiber. Low-density lipoprotein-cholesterol levels and the atherogenic index had the same tendency as total cholesterol concentration. Compared with the FF group, in the 5P, 5QM, 10P, and 10QM groups hepatic triglyceride concentrations were 12%, 16%, 20%, and 24% lower, respectively, and hepatic cholesterol concentrations were 48%, 52%, 52%, and 58% lower, respectively. Hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity in the soluble fiber groups was significantly higher than in the FF groups, but lower than the normal group. When hepatic tissue was observed under a light microscope, the FF group had completely formed lipomas in the hepatic tissue, which led to fat deposits and then a fatty liver. The size and number of lipomas were lower in the soluble dietary fiber-fed groups, as compared with the group not fed dietary fiber. In conclusion, improvements in lipid metabolism were observed as a result of the manufactured soluble dietary fiber from the oak chips, and were similar to that seen for pectin. The preparation method for the soluble dietary fiber from oak chips successfully produced a functional soluble fiber.

Objective: We report magnetic resonance imaging (MRI) findings on focal anterior displacement of the thoracic spinal cord in asymptomatic patients without a spinal cord herniation or intradural mass. Materials and Methods: We identified 12 patients (male:female = 6:6; mean age, 51.7; range, 15–83 years) between 2007 and 2011, with focal anterior displacement of the spinal cord and without evidence of an intradural mass or spinal cord herniation. Two radiologists retrospectively reviewed the MRI findings in consensus. Results: An asymmetric spinal cord deformity with a focal dented appearance was seen on the posterior surface of the spinal cord in all patients, and it involved a length of 1 or 2 vertebral segments in the upper thoracic spine (thoracic vertebrae 1–6). Moreover, a focal widening of the posterior subarachnoid space was also observed in all cases. None of the patients had myelopathy symptoms, and they showed no focal T2-hyperintensity in the spinal cord with the exception of one patient. In addition, cerebrospinal fluid (CSF) flow artifacts were seen in the posterior subarachnoid space of the affected spinal cord level. Computed tomography myelography revealed preserved CSF flow in the two available patients. Conclusion: Focal anterior spinal cord indentation can be found in the upper thoracic level of asymptomatic patients without a spinal cord herniation or intradural mass. Index terms: Thoracic spine; MRI; Spinal cord deformity

Pseudohypoparathyroidism type Ia (PHP Ia) is a disorder characterized by multiform hormonal resistance including parathyroid hormone (PTH) resistance and Albright hereditary osteodystrophy (AHO). It is caused by heterozygous inactivating mutations within the Gs alpha-encoding GNAS exons. A 9-year-old boy presented with clinical and laboratory abnormalities including hypocalcemia, hyperphosphatemia, PTH resistance, multihormone resistance and AHO (round face, short stature, obesity, brachydactyly and osteoma cutis) which were typical of PHP Ia. He had a history of repeated convulsive episodes that started from the age of 2 months. A cranial computed tomography scan showed bilateral calcifications in the basal ganglia and his intelligence quotient testing indicated mild mental retardation. Family history revealed that the patient's maternal relatives, including his grandmother and 2 of his mother's siblings, had features suggestive of AHO. Sequencing of the GNAS gene of the patient identified a heterozygous nonsense mutation within exon 11 (c.637 C>T). The C>T transversion results in an amino acid substitution from Gln to stop codon at codon 213 (p.Gln213*). To our knowledge, this is a novel mutation in GNAS.

Background: Clinical diagnosis of multiple system atrophy (MSA) relays on signs and symptoms that are often difficult to identify particularly at early stage. Indeed neuropathological studies have demonstrated that Parkinson variant of MSA (MSA-P) is the first cause of misdiagnosis in a cohort of patients presenting with parkinsonian features. But accurate diagnosis of these disorders is important for deciding on treatment, appropriate advice and prognosis since atypical parkinsonian disorders are characterized by poor response to dopaminergic treatment and more rapid disease progression. Therefore, we conducted this study to investigate difference of perfusion Single Photon Emission Computed Tomography (SPECT) in patients with the early phase of MSA-P using SPM program. Methods: We recruited consecutively 21 patients with MSA-P and 48 age-matched healthy controls. All subjects underwent Tc-99m HMPAO perfusion SPECT and this perfusion images were analyzed. Results: For MSA-P, only hypoperfusion was seen in the middle frontal gyrus of left frontal lobe, superior frontal gyrus of right frontal lobe, precentral gyrus of left frontal lobe, middle frontal gyrus of right frontal lobe and precentral gyrus of right frontal lobe with respect to healthy subjects. Conclusions: We cautiously assume that perfusion SPECT may offer significant advantages compared to other imaging techniques in the assessment of neuronal degeneration in MSA-P and may help the clinician in the diagnostic characterization of patients presenting with atypical parkinsonism. Received: May 16, 2014 Revision received: May 28, 2014 Accepted: May 28, 2014

Hutchinson-Gilford progeria syndrome (HGPS) is a rare condition originally described by Hutchinson in 1886. Death result from cardiac complications in the majority of cases and usually occurs at average age of thirteen years. A 4-yr old boy had typical clinical findings such as short stature, craniofacial disproportion, alopecia, prominent scalp veins and sclerodermatous skin. This abnormal appearance began at age of 1 yr. On serological and hormonal evaluation, all values are within normal range. He was neurologically intact with motor and mental development. An echocardiogram showed calcification of aortic and mitral valves. Hypertrophy of internal layer at internal carotid artery suggesting atherosclerosis was found by carotid doppler sonography. He is on low dose aspirin to prevent thromboembolic episodes and on regular follow up. Gene study showed typical G608G (GGC- > GGT) point mutation at exon 11 in LMNA gene. This is a rare case of Hutchinson-Gilford progeria syndrome confirmed by genetic analysis in Korea.

Purpose: To report early results of supportive bone cement replacement for medium to large size osteonecrotic femoral heads in young patients. Materials and Methods: Forty-one osteonecrotic femoral heads in 38 patients, who received operation from Mar. 1998 to Feb. 2000, were reviewed. The mean age of the patients was 34.2 years (men; 33, women; 5). The preoperative mean Harris score was 48.6. Radiologic staging of Ficat showed I in 2 hips (5%), II-A in 7 hips (17%), II-B in 8 hips (20%) and III in 24 hips (59%). According to the index of necrotic extent (INE) by MRI, 8 hips (20%) were grade B and the remaining 33 hips (80%) were grade C. The operative method used was debridement of necrotic bone and bone cement replacement. Mean length of follow-up was 24.6 months. Three hips were lost to final follow-up. Results: Postoperative immediate pain relief was observed in 38 hips (86%). Mean Harris score at the final follow-up was 77.3. Radiologic progression of stage was observed in 11 hips (27%), and no progression in the remaining 30 hips (73%). Arthoplasty was performed in 6 hips (15%), which were INE C in all cases. Conclusion: Supportive bone cement replacement is easier than other salvage techniques and produced a good result. INE was an important factor effecting postoperative results. Long term follow up is necessary.