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622 results on '"Ju, Rui"'

105. Three-stage binarization of color document images based on discrete wavelet transform and generative adversarial networks

Author

Lin, Yu-Shian, Ju, Rui-Yang, Chen, Chih-Chia, Lin, Ting-Yu, and Chiang, Jen-Shiun

Subjects
FOS: Computer and information sciences, Computer Vision and Pattern Recognition (cs.CV), Computer Science - Computer Vision and Pattern Recognition
Abstract

The efficient segmentation of foreground text information from the background in degraded color document images is a hot research topic. Due to the imperfect preservation of ancient documents over a long period of time, various types of degradation, including staining, yellowing, and ink seepage, have seriously affected the results of image binarization. In this paper, a three-stage method is proposed for image enhancement and binarization of degraded color document images by using discrete wavelet transform (DWT) and generative adversarial network (GAN). In Stage-1, we use DWT and retain the LL subband images to achieve the image enhancement. In Stage-2, the original input image is split into four (Red, Green, Blue and Gray) single-channel images, each of which trains the independent adversarial networks. The trained adversarial network models are used to extract the color foreground information from the images. In Stage-3, in order to combine global and local features, the output image from Stage-2 and the original input image are used to train the independent adversarial networks for document binarization. The experimental results demonstrate that our proposed method outperforms many classical and state-of-the-art (SOTA) methods on the Document Image Binarization Contest (DIBCO) dataset. We release our implementation code at https://github.com/abcpp12383/ThreeStageBinarization.

Published
2022
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106. Supplemental Material - Progesterone Receptor Membrane Component-1 May Promote Survival of Human Brain Microvascular Endothelial Cells in Alzheimer’s Disease

Author

Xu, Xin, Ruan, Xiangyan, Ju, Rui, Wang, Zhikun, Yang, Yu, Cheng, Jiaojiao, Gu, Muqing, and Mueck, Alfred O.

Subjects
111099 Nursing not elsewhere classified, FOS: Clinical medicine, FOS: Health sciences, humanities, 110308 Geriatrics and Gerontology, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplementary Material for Progesterone Receptor Membrane Component-1 May Promote Survival of Human Brain Microvascular Endothelial Cells in Alzheimer’s Disease by Xin Xu, Xiangyan Ruan, Rui Ju, Zhikun Wang, Yu Yang, Jiaojiao Cheng, Muqing Gu, and Alfred O. Mueck in American Journal of Alzheimer's Disease & Other Dementias®.

Published
2022
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124. Application of Multifunctional Targeting Epirubicin Liposomes in the Treatment of Non-Small-Cell Lung Cancer [Corrigendum]

Author

Song,Xiao-li, Ju,Rui-jun, Xiao,Yao, Wang,Xin, Liu,Shuang, Fu,Min, Liu,Jing-jing, Gu,Li-yan, Li,Xue-tao, Cheng,Lan, Song,Xiao-li, Ju,Rui-jun, Xiao,Yao, Wang,Xin, Liu,Shuang, Fu,Min, Liu,Jing-jing, Gu,Li-yan, Li,Xue-tao, and Cheng,Lan

Abstract

Song X, Ju R, Xiao Y, et al. Int J Nanomedicine. 2017;12:7433‒7451. The authors have advised due to an error at the time of figure assembly, Figure 5 on page 7442 is incorrect. The correct Figure 5 is shown in Download Article.   The authors apologize for this error and advise it does not affect the results of the paper. Read the original article

Published
2021

125. Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC [Corrigendum]

Author

Kong,Liang, Zhang,Shi-meng, Chu,Jia-hao, Liu,Xin-ze, Zhang,Lu, He,Si-yu, Yang,Si-min, Ju,Rui-jun, Li,Xue-tao, Kong,Liang, Zhang,Shi-meng, Chu,Jia-hao, Liu,Xin-ze, Zhang,Lu, He,Si-yu, Yang,Si-min, Ju,Rui-jun, and Li,Xue-tao

Abstract

Kong L, Zhang S, Chu J, et al. Int J Nanomedicine. 2020;15:6451–6468. The authors have advised due to an error at the time of figure assembly, Figure 6A on page 6463 is incorrect. The correct Figure 6 is shown in Download Article.   The authors apologize for this error and advise it does not affect the results of the paper. Read the original article

Published
2021

128. Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice

Author

Kong,Liang, Li,Xue-tao, Ni,Ying-nan, Xiao,Hong-he, Yao,Ying-jia, Wang,Yuan-yuan, Ju,Rui-jun, Li,Hong-yan, Liu,Jing-jing, Fu,Min, Wu,Yu-tong, Yang,Jing-xian, and Cheng,Lan

Subjects
International Journal of Nanomedicine, fungi
Abstract

Liang Kong,1 Xue-tao Li,1 Ying-nan Ni,1 Hong-he Xiao,1 Ying-jia Yao,2 Yuan-yuan Wang,3 Rui-jun Ju,4 Hong-yan Li,1 Jing-jing Liu,1 Min Fu,1 Yu-tong Wu,1 Jing-xian Yang,1 Lan Cheng1 1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People’s Republic of China; 2College of Life and Health Sciences, Northeastern University, Shenyang 110819, People’s Republic of China; 3Department of Pharmacy, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, People’s Republic of China; 4Department of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, People’s Republic of ChinaCorrespondence: Jing-xian Yang; Lan Cheng Email jingxianyang0520@163.com; sychenglan@163.comIntroduction: Osthole (Ost) is a coumarin compound that strengthens hippocampal neurons and neural stem cells against Aβ oligomer-induced neurotoxicity in mice, and is a potential drug for the treatment of Alzheimer’s disease (AD). However, the effectiveness of the drug is limited by its solubility and bioavailability, as well as by the low permeability of the blood-brain barrier (BBB). In this study, a kind of transferrin-modified Ost liposomes (Tf-Ost-Lip) was constructed, which could improve the bioavailability and enhance brain targeting.Methods: Tf-Ost-Lip was prepared by thin-film hydration method. The ability of liposomal formulations to translocate across BBB was investigated using in vitro BBB model. And the protective effect of Tf-Ost-Lip was evaluated in APP-SH-SY5Y cells. In addition, we performed pharmacokinetics study and brain tissue distribution analysis of liposomal formulations in vivo. We also observed the neuroprotective effect of the varying formulations in APP/PS-1 mice.Results: In vitro studies reveal that Tf-Ost-Lip could increase the intracellular uptake of hCMEC/D3 cells and APP-SH-SY5Y cells, and increase the drug concentration across the BBB. Additionally, Tf-Ost-Lip was found to exert a protective effect on APP-SH-SY5Y cells. In vivo studies of pharmacokinetics and the Ost distribution in brain tissue indicate that Tf-Ost-Lip prolonged the cycle time in mice and increased the accumulation of Ost in the brain. Furthermore, Tf-Ost-Lip was also found to enhance the effect of Ost on the alleviation of Alzheimer’s disease-related pathology.Conclusion: Transferrin-modified liposomes for delivery of Ost has great potential for AD treatment.Keywords: transferrin, osthole, liposomes, blood-brain barrier, Alzheimer’s disease

Published
2020

129. Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC

Author

Kong,Liang, Zhang,Shi-meng, Chu,Jia-hao, Liu,Xin-ze, Zhang,Lu, He,Si-yu, Yang,Si-min, Ju,Rui-jun, Li,Xue-tao, Kong,Liang, Zhang,Shi-meng, Chu,Jia-hao, Liu,Xin-ze, Zhang,Lu, He,Si-yu, Yang,Si-min, Ju,Rui-jun, and Li,Xue-tao

Abstract

Liang Kong, 1 Shi-meng Zhang, 2 Jia-hao Chu, 3 Xin-ze Liu, 1 Lu Zhang, 1 Si-yu He, 1 Si-min Yang, 3 Rui-jun Ju, 3 Xue-tao Li 1 1School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, People’s Republic of China; 2Department of Neurology, Linyi People’s Hospital, Linyi 276003, People’s Republic of China; 3Department of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Beijing 102617, People’s Republic of ChinaCorrespondence: Xue-tao LiSchool of Pharmacy, Liaoning University of Traditional Chinese Medicine, Shengming 1 Road 77, Double D Port, Dalian 116600, People’s Republic of ChinaTel +86411 8589 0170Fax +86411 8589 0128Email lixuetao1979@163.comRui-jun JuDepartment of Pharmaceutical Engineering, Beijing Institute of Petrochemical Technology, Qingyuan North Road 19, Beijing 102617, People’s Republic of ChinaTel +8610 8129 2387Fax +8610 8129 2124Email juruijun@bipt.edu.cnBackground: Non-small cell lung cancer (NSCLC) is one of the most lethal types of cancer with highly infiltrating. Chemotherapy is far from satisfactory, vasculogenic mimicry (VM) and angiogenesis results in invasion, migration and relapse.Purpose: The objective of this study was to construct a novel CPP (mmp) modified vinorelbine and dioscin liposomes by two new functional materials, DSPE-PEG 2000-MAL and CPP-PVGLIG-PEG 5000, to destroy VM channels, angiogenesis, EMT and inhibit invasion and migration.Methods and Results: The targeting liposomes could be enriched in tumor sites through passive targeting, and the positively charged CPP was exposed and enhanced active targeting via electrostatic adsorption after being hydrolyzed by MMP2 enzymes overexpressed in the tumor microenvironment. We found that CPP (mmp) modified vinorelbine and dioscin liposomes with the ideal physicochemical properties and exhibited enhanced cellular uptake. In vitro and in vivo results showed that CPP (mmp) m

Published
2020

132. Polarization-preserved and polarization-rotated synchronization of chaotic vertical-cavity surface-emitting lasers

Author

Ju, Rui, Spencer, Paul S., and Alan Shore, K.

Subjects
Chaos theory -- Analysis, Semiconductor lasers -- Design and construction, Polarization (Light) -- Analysis, Business, Computers, Electronics, Electronics and electrical industries
Abstract

A numerical investigation of the polarization synchronization properties of chaotic VCSELs (Vertical-Cavity Surface-Emitting Lasers) in a master-slave configuration is presented. Two types of synchronization are identified in the polarization-rotated case, one of which can afford an opportunity to effect multiplexed message encoding using orthogonal laser modes.

Published
2005

140. Multifunctional osthole liposomes and brain targeting functionality with potential applications in a mouse model of Alzheimer’s disease

Author

Ni, Ying-Nan, primary, Kong, Liang, additional, Li, Xue-Tao, additional, Xiao, Hong-He, additional, Wu, Yu-Tong, additional, Liang, Xi-Cai, additional, Lin, Ying, additional, Li, Wan-Yi, additional, Deng, Yan, additional, Li, Yan, additional, Shi, Yue, additional, Cheng, Lan, additional, Li, Hong-Yan, additional, Ju, Rui-Jun, additional, and Yang, Jing-Xian, additional

Published
2020
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143. Carboxyamidotriazole exerts anti‑inflammatory activity in lipopolysaccharide‑induced RAW264.7 macrophages by inhibiting NF‑κB and MAPKs pathways

Author

Lu, Shan, primary, Duan, Mengyuan, additional, Guo, Zehao, additional, Zhou, Yongting, additional, Wu, Danwei, additional, Zhang, Xiaojuan, additional, Wang, Yicheng, additional, Ye, Caiying, additional, Ju, Rui, additional, Li, Juan, additional, Zhang, Dechang, additional, and Zhu, Lei, additional

Published
2020
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150. Efficacy and safety of Zi Gui Nv Zhen® capsules used in TCM for fertility preservation in patients with diminished ovarian reserve.

Author

Xu, Zhongting, Ruan, Xiangyan, Xu, Xin, Yang, Yu, Cheng, Jiaojiao, Luo, Suiyu, Min, Min, Li, Meng, Zhang, Luping, Ju, Rui, Jin, Fengyu, and Mueck, Alfred Otto

Subjects
OVARIAN reserve, FERTILITY preservation, ANTI-Mullerian hormone, CHINESE medicine, NEUROENDOCRINE system
Abstract

Copyright of Gynecological Endocrinology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022
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