3,779 results on '"Kastner P"'
Search Results
102. Interventions that have potential to help older adults living with social frailty: a systematic scoping review
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Monika Kastner, Isabella Herrington, Julie Makarski, Krystle Amog, Tejia Bain, Vianca Evangelista, Leigh Hayden, Alexa Gruber, Justin Sutherland, Amy Sirkin, Laure Perrier, Ian D. Graham, Michelle Greiver, Joan Honsberger, Mary Hynes, Charlie Macfarlane, Leela Prasaud, Barbara Sklar, Margo Twohig, Barbara Liu, Sarah Munce, Sharon Marr, Braden O’Neill, Alexandra Papaioannou, Bianca Seaton, Sharon E. Straus, Katie Dainty, and Jayna Holroyd-Leduc
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Older adults ,Social frailty ,Geriatrics ,Scoping review ,Self-management ,Information communication technology ,RC952-954.6 - Abstract
Abstract Background The impact of social frailty on older adults is profound including mortality risk, functional decline, falls, and disability. However, effective strategies that respond to the needs of socially frail older adults are lacking and few studies have unpacked how social determinants operate or how interventions can be adapted during periods requiring social distancing and isolation such as the COVID-19 pandemic. To address these gaps, we conducted a scoping review using JBI methodology to identify interventions that have the best potential to help socially frail older adults (age ≥65 years). Methods We searched MEDLINE, CINAHL (EPSCO), EMBASE and COVID-19 databases and the grey literature. Eligibility criteria were developed using the PICOS framework. Our results were summarized descriptively according to study, patient, intervention and outcome characteristics. Data synthesis involved charting and categorizing identified interventions using a social frailty framework. Results Of 263 included studies, we identified 495 interventions involving ~124,498 older adults who were mostly female. The largest proportion of older adults (40.5%) had a mean age range of 70-79 years. The 495 interventions were spread across four social frailty domains: social resource (40%), self-management (32%), social behavioural activity (28%), and general resource (0.4%). Of these, 189 interventions were effective for improving loneliness, social and health and wellbeing outcomes across psychological self-management, self-management education, leisure activity, physical activity, Information Communication Technology and socially assistive robot interventions. Sixty-three interventions were identified as feasible to be adapted during infectious disease outbreaks (e.g., COVID-19, flu) to help socially frail older adults. Conclusions Our scoping review identified promising interventions with the best potential to help older adults living with social frailty.
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- 2024
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103. Evaluation of an online arts-based platform to support the health and well-being of older adults during the COVID-19 pandemic: a cross-sectional survey
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Justin Sutherland, Isabella Herrington, Julie Makarski, Jennifer Tindall, Mary Hynes, and Monika Kastner
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Older adults ,Arts-based intervention ,COVID-19 ,Social isolation ,Loneliness ,Survey ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Objectives The objective of this study was to conduct a formative evaluation of the Art Your Service (AYS) arts-based program to determine the program’s potential for improving the social and physical well-being of older adults during the COVID-19 pandemic. Design, settings and participants An online questionnaire was administered to the AYS members who consented to be invited to participate in the study. Questionnaire items consisted of a Likert scale and open-ended questions delivered using an online platform (SurveyMonkey). Participants provided feedback on their perceptions and experiences of the AYS program, such as its impact on their health and well-being during the COVID-19 pandemic, the benefits and challenges of participating, and any suggestions for program improvement. Outcome measures and analysis Quantitative data were analyzed using descriptive statistics (frequencies, means with standard deviations), and open-ended questions (qualitative data) were analyzed using content analysis. Outcomes included participant demographics, perceptions about the program, usability (System Usability Scale [SUS]), eHealth literacy (eHealth Literacy Scale), and social isolation (Lubben Social Network Scale; LSNS-6). Results Program participants revealed consistent patterns of their perceptions and experiences about the program, including a high satisfaction rate (95%) and a perceived positive impact on participants’ health and well-being. The program sessions were perceived to be a well-organized, convenient, and safe way to engage with one another socially during the COVID-19 pandemic. The program usability was also perceived to be high (SUS mean score 86.2). Participants felt a sense of connectedness and had reduced feelings of social isolation. Most participants (75%) reported that the program improved their physical health. Conclusions Findings from this formative evaluation study identified key strengths and opportunities to improve the Art Your Service arts-based program, which can be used to help enhance the program’s functioning and long-term sustainability potential.
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- 2024
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104. Panchromatic HST/WFC3 Imaging Studies of Young, Rapidly Evolving Planetary Nebulae. II. NGC 7027
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Baez, Paula Moraga, Kastner, Joel H., Balick, Bruce, Montez Jr., Rodolfo, and Bublitz, Jesse
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The iconic planetary nebula (PN) NGC 7027 is bright, nearby (D ~ 1 kpc), highly ionized, intricately structured, and well observed. This nebula is hence an ideal case study for understanding PN shaping and evolution processes. Accordingly, we have conducted a comprehensive imaging survey of NGC 7027 comprised of twelve HST Wide Field Camera 3 images in narrow-band and continuum filters spanning the wavelength range 0.243--1.67 microns. The resulting panchromatic image suite reveals the spatial distributions of emission lines covering low-ionization species such as singly ionized Fe, N, and Si, through H recombination lines, to more highly ionized O and Ne. These images, combined with available X-ray and radio data, provide the most extensive view of the structure of NGC 7027 obtained to date. Among other findings, we have traced the ionization structure and dust extinction within the nebula in sub-arcsecond detail; uncovered multipolar structures actively driven by collimated winds that protrude through and beyond the PN's bright inner core; compared the ionization patterns in the WFC3 images to X-ray and radio images of its interior hot gas and to its molecular outflows; pinpointed the loci of thin, shocked interfaces deep inside the nebula; and more precisely characterized the central star. We use these results to describe the recent history of this young and rapidly evolving PN in terms of a series of shaping events. This evolutionary sequence involves both thermal and ram pressures, and is far more complex than predicted by extant models of UV photoionization or winds from a single central progenitor star, thereby highlighting the likely influence of an unseen binary companion., Comment: ApJ, in press; 26 pages, 13 figures, 2 tables
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- 2022
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105. Investigating 2M1155-7919B: a Nearby, Young, Low-Mass Star Actively Accreting from a Nearly Edge-on, Dusty Disk
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Dickson-Vandervelde, D. Annie, Kastner, Joel H., Gagné, Jonathan, Schneider, Adam C., Faherty, Jacqueline, Wilson, Emily C., Pinte, Christophe, and Ménard, Francois
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
We investigate the nature of an unusually faint member of the $\epsilon$ Cha Association ($D\sim100$ pc, age $\sim5$ Myr), the nearest region of star formation of age $<$8 Myr. This object, 2MASS J11550336-7919147 (2M1155$-$79B), is a wide ($\sim$580 AU) separation, comoving companion to low-mass (M3) $\epsilon$ Cha Association member 2MASS J11550485-7919108 (2M1155$-$79A). We present near-infrared spectra of both components, along with analysis of photometry from Gaia EDR3, 2MASS, VHS, and WISE. The near-IR spectrum of 2M1155$-$79B displays strong He I 1.083 emission, a sign of active accretion and/or accretion-driven winds from a circumstellar disk. Analysis of WISE archival data reveals that the mid-infrared excess previously associated with 2M1155$-$79A instead originates from the disk surrounding 2M1155$-$79B. Based on these results, as well as radiative transfer modeling of its optical/IR spectral energy distribution, we conclude that 2M1155$-$79B is most likely a young, late-M, star that is partially obscured by, and actively accreting from, a nearly edge-on circumstellar disk. This would place 2M1155$-$79B among the rare group of nearby ($D\lesssim100$ pc), young (age $<$10 Myr) mid-M stars that are orbited by and accreting from highly inclined protoplanetary disks. Like these systems, the 2M1155$-$79B system is a particularly promising subject for studies of star and planet formation around low-mass stars., Comment: 11 pages, 6 figures, accepted for publication in AJ
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- 2022
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106. Mapping NGC 7027 in New Light: CO$^+$ and HCO$^+$ Emission Reveal Its Photon- and X-ray-Dominated Regions
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Bublitz, Jesse, Kastner, Joel H., Hily-Blant, Pierre, Forveille, Thierry, Santander-García, Miguel, Alcolea, Javier, Bujarrabal, Valentin, Wilner, David J., Montez, Jr., Rodolfo, and Aleman, Isabel
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The young and well-studied planetary nebula NGC 7027 harbors significant molecular gas that is irradiated by luminous, point-like UV (central star) and diffuse (shocked nebular) X-ray emission. This nebula represents an excellent subject to investigate the molecular chemistry and physical conditions within photon- and X-ray-dominated regions (PDRs and XDRs). As yet, the exact formation routes of CO$^+$ and HCO$^+$ in PN environments remain uncertain. Here, we present $\sim$2$"$ resolution maps of NGC 7027 in the irradiation tracers CO$^+$ and HCO$^+$, obtained with the IRAM NOEMA interferometer, along with SMA CO and HST 2.12~$\mu$m H$_2$ data for context. The CO$^+$ map constitutes the first interferometric map of this molecular ion in any PN. Comparison of CO$^+$ and HCO$^+$ maps reveal strikingly different emission morphologies, as well as a systematic spatial displacement between the two molecules; the regions of brightest HCO$^+$, found along the central waist of the nebula, are radially offset by $\sim$1$"$ ($\sim$900 au) outside the corresponding CO$^+$ emission peaks. The CO$^+$ emission furthermore precisely traces the inner boundaries of the nebula's PDR (as delineated by near-IR H$_2$ emission), suggesting that central star UV emission drives CO$^+$ formation. The displacement of HCO$^+$ radially outward with respect to CO$^+$ is indicative that dust-penetrating soft X-rays are responsible for enhancing the HCO$^+$ abundance in the surrounding molecular envelope, forming an XDR. These interferometric CO$^+$ and HCO$^+$ observations of NGC 7027 thus clearly establish the spatial distinction between the PDR and XDR formed (respectively) by intense UV and X-ray irradiation of molecular gas., Comment: 15 pages, 7 figures, 1 table
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- 2022
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107. Unusual magnetotransport in twisted bilayer graphene from strain-induced open Fermi surfaces
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Wang, Xiaoyu, Finney, Joe, Sharpe, Aaron L., Rodenbach, Linsey K., Hsueh, Connie L., Watanabe, Kenji, Taniguchi, Takashi, Kastner, M. A., Vafek, Oskar, and Goldhaber-Gordon, David
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Strongly Correlated Electrons - Abstract
Anisotropic hopping in a toy Hofstadter model was recently invoked to explain a rich and surprising Landau spectrum measured in twisted bilayer graphene away from the magic angle. Suspecting that such anisotropy could arise from unintended uniaxial strain, we extend the Bistritzer-MacDonald model to include uniaxial heterostrain. We find that such strain strongly influences band structure, shifting the three otherwise-degenerate van Hove points to different energies. Coupled to a Boltzmann magnetotransport calculation, this reproduces previously-unexplained non-saturating $B^2$ magnetoresistance over broad ranges of density near filling $\nu=\pm 2$, and predicts subtler features that had not been noticed in the experimental data. In contrast to these distinctive signatures in longitudinal resistivity, the Hall coefficient is barely influenced by strain, to the extent that it still shows a single sign change on each side of the charge neutrality point -- surprisingly, this sign change no longer occurs at a van Hove point. The theory also predicts a marked rotation of the electrical transport principal axes as a function of filling even for fixed strain and for rigid bands. More careful examination of interaction-induced nematic order versus strain effects in twisted bilayer graphene could thus be in order., Comment: 11 pages main text (4 figures) + 8 pages supplementary material (11 figures)
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- 2022
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108. Gravity from Transactions: Fulfilling the Entropic Gravity Program
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Schlatter, A. and Kastner, R. E.
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General Relativity and Quantum Cosmology ,Physics - History and Philosophy of Physics ,Quantum Physics - Abstract
This is a review of new developments in entropic gravity in light of the Relativistic Transactional Interpretation (RTI). A transactional approach to spacetime events can give rise in a natural way to entropic gravity (in the way originally proposed by Erik Verlinde) while also overcoming extant objections to that research program. The theory also naturally gives rise to a Cosmological Constant and to Modified Newtonian Dynamics (MOND) and thus provides a physical explanation for the phenomena historically attributed to "dark energy" and "dark matter"., Comment: Final accepted version, Journal of Physics Communications (2023)
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- 2022
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109. Reproducibility Companion Paper: Describing Subjective Experiment Consistency by $p$-Value P-P Plot
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Nawała, Jakub, Janowski, Lucjan, Ćmiel, Bogdan, Rusek, Krzysztof, Kastner, Marc A., and Zahálka, Jan
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Computer Science - Multimedia ,H.5.1 ,G.3 - Abstract
In this paper we reproduce experimental results presented in our earlier work titled "Describing Subjective Experiment Consistency by $p$-Value P-P Plot" that was presented in the course of the 28th ACM International Conference on Multimedia. The paper aims at verifying the soundness of our prior results and helping others understand our software framework. We present artifacts that help reproduce tables, figures and all the data derived from raw subjective responses that were included in our earlier work. Using the artifacts we show that our results are reproducible. We invite everyone to use our software framework for subjective responses analyses going beyond reproducibility efforts., Comment: Please refer to the original publication: https://dl.acm.org/doi/10.1145/3474085.3477935 Related paper: https://dl.acm.org/doi/abs/10.1145/3394171.3413749 or arXiv:2009.13372
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- 2022
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110. Active Learning Exploration of Transition Metal Complexes to Discover Method-Insensitive and Synthetically Accessible Chromophores
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Duan, Chenru, Nandy, Aditya, Terrones, Gianmarco, Kastner, David W., and Kulik, Heather J.
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Physics - Chemical Physics ,Condensed Matter - Materials Science ,Computer Science - Machine Learning ,Quantitative Biology - Biomolecules - Abstract
Transition metal chromophores with earth-abundant transition metals are an important design target for their applications in lighting and non-toxic bioimaging, but their design is challenged by the scarcity of complexes that simultaneously have optimal target absorption energies in the visible region as well as well-defined ground states. Machine learning (ML) accelerated discovery could overcome such challenges by enabling screening of a larger space, but is limited by the fidelity of the data used in ML model training, which is typically from a single approximate density functional. To address this limitation, we search for consensus in predictions among 23 density functional approximations across multiple rungs of Jacobs ladder. To accelerate the discovery of complexes with absorption energies in the visible region while minimizing MR character, we use 2D efficient global optimization to sample candidate low-spin chromophores from multi-million complex spaces. Despite the scarcity (i.e., approx. 0.01\%) of potential chromophores in this large chemical space, we identify candidates with high likelihood (i.e., > 10\%) of computational validation as the ML models improve during active learning, representing a 1,000-fold acceleration in discovery. Absorption spectra of promising chromophores from time-dependent density functional theory verify that 2/3 of candidates have the desired excited state properties. The observation that constituent ligands from our leads have demonstrated interesting optical properties in the literature exemplifies the effectiveness of our construction of a realistic design space and active learning approach.
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- 2022
111. Spectroscopic Observations of the GALEX Nearby Young Star Survey Sample. I. Nearby Moving Group Candidates
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Navya Nagananda, Laura Vican, Ben Zuckerman, David Rodriguez, Alexander Binks, and Joel Kastner
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Astronomy ,QB1-991 ,Astrophysics ,QB460-466 - Abstract
The GALEX Nearby Young Star Search (GALNYSS) yielded the identification of more than 2000 late-type stars that, based on their ultraviolet and infrared colors and pre-Gaia proper motions, are potentially of age
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- 2024
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112. Ceramic additive manufacturing and microstructural analysis of tricalcium phosphate implants using X-ray microcomputed tomography
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Sascha Senck, Jonathan Glinz, Sarah Heupl, Johann Kastner, Klemens Trieb, Uwe Scheithauer, Sif Sofie Dahl, and Martin Bonde Jensen
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Additive manufacturing ,Bone implants ,Ceramics ,Porosity ,Microcomputed tomography ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
Additive manufacturing (AM) of ceramic bone implants from tricalcium phosphate (TCP) offers several benefits for bone regeneration and defect treatment. TCP scaffolds, e.g. featuring lattice or gyroid geometries, can effectively induce bone ingrowth and integration, showing a high potential in the treatment of large bone defects, e.g. as filler material for large bone defects. A major advantage of TCP is its osteoconductivity making it an effective choice for a broad range of orthopedic and dental applications. In addition, AM allows for the possibility to create precise, patient-specific implants with controllable mechanical properties. Those properties can be controlled by the implants' microstructure, e.g. in relation to bulk density and internal porosity. In this contribution, eleven resorbable bone implants were produced from β-tricalcium phosphate (β-TCP) in order to quantify the internal porosity in three dimensions using microcomputed tomography (μ CT). All components were manufactured using an extrusion-based process and scanned using an industrial μCT system at a voxel size of 10 μm. Two samples were physically prepared to allow a high-resolution μCT analysis at a voxel size of 1 μm. Results show that post-processed image data enables the non-destructive inspection of highly complex ceramic AM implants. Using μCT we were able to quantify internal porosity in β-TCP bone implant and quantify the geometry and distribution of wall thicknesses in the gyroid geometry. However, a detailed microstructural analysis is only possible using high-resolution μCT volume data, e.g. in relation to internal porosity. The findings emphasize that ceramic AM is able to produce complex components. However, NDT using μCT is crucial in the development of new materials and geometries. μCT provides high-resolution insights into the internal and external structure of ceramic AM components. It plays a critical role in detecting internal features, including small-scale porosity and delamination which are crucial for the integrity and functionality of medical implants. Moreover, μCT provides volumetric data that supports the design and manufacturing process at various stages, enabling an iterative approach of continuous improvement in mechanical performance and osseointegration.
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- 2024
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113. Role of the dengue vaccine TAK-003 in an outbreak response: Modeling the Sri Lanka experience.
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LakKumar Fernando, Randee Kastner, Pujitha Wickramasinghe, Asvini D Fernando, Dulanie Gunasekera, Van Hung Nguyen, Mengya Liu, Inge LeFevre, Derek Wallace, Nicolas Folschweiller, and Shibadas Biswal
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundOutbreaks of dengue can overburden hospital systems, drastically reducing capacity for other care. The 2017 dengue serotype 2 (DENV-2) outbreak in Sri Lanka coincided with vaccination in an ongoing phase 3 efficacy trial of a tetravalent dengue vaccine, TAK-003 (NCT02747927). Here, we present data on the efficacy of TAK-003 following two doses of the vaccine administered 3 months apart in participants aged 4-16 years in Sri Lanka. In addition, we have used the 2017 outbreak dynamics to model the potential impact of TAK-003 on virologically confirmed dengue (VCD) cases and hospitalizations during an outbreak situation.Methodology/principal findingsModeling was performed using an age-structured, host-vector, spatial and stochastic transmission model, assuming 65% vaccine coverage and 30 days until initiation of vaccination. Efficacy of TAK-003 against VCD and hospitalized VCD cases was based on data against DENV-2 from the first year of the phase 3 trial. Vaccine efficacy and safety findings in Sri Lanka were in line with those of the overall trial population. The efficacy estimates in Sri Lanka up to the first 12 months after the second dose of TAK-003 were 94.7% and 95.7% against VCD and hospitalized VCD cases, respectively. Modeling of the trial data over an extended geographic area showed a substantial reduction in cases and a flattening of outbreak curves from TAK-003 use. The baseline vaccination scenario (initiation at 30 days, 65% target coverage, vaccine effective at 14 days, 70% hospitalization rate, VE of 95% for VCD and 97% for hospitalized VCD, and 47% for asymptomatic) resulted in a 69.1% reduction in VCD cases and 72.7% reduction in VCD hospitalizations compared with no vaccination. An extreme high scenario (vaccination initiated at Day 15, 80% coverage rate, baseline VE) resulted in 80.3% and 82.3% reduction in VCD and VCD hospitalizations, respectively. Vaccine performance, speed of vaccination campaign initiation, and vaccine coverage were key drivers in reducing VCD cases and hospitalizations.Conclusions/significanceOverall, the study and modeling results indicate that TAK-003 has the potential of meaningful utility in dengue outbreaks in endemic areas.
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- 2024
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114. CO line observations of OH/IR stars in the inner Galactic Bulge: Characteristics of stars at the tip of the AGB
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Olofsson, H., Khouri, T., Sargent, B. A., Winnberg, A., Blommaert, J. A. D. L., Groenewegen, M. A. T., Muller, S., Kastner, J. H., Meixner, M., Otsuka, M., Patel, N., Ryde, N., and Srinivasan, S.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
12CO and 13CO lines, as well as a mm-wave continuum, have been observed for a sample of 22 OH/IR stars in directions within 2 degrees of the Galactic Centre. Photometry data have been gathered from the literature to construct SEDs and to determine pulsational variability. Radiative transfer models have been used to interpret the data. All stars in the sample were detected in at least one CO line, and 8 objects were detected in 324 GHz continuum. Based on luminosity criteria, the sample is divided into 17 objects that most likely lie within the inner Galactic Bulge, and 5 objects that are most likely foreground objects. The median luminosity of the inner-Galactic-Bulge objects, 5600 Lsun, corresponds to an initial mass in the range 1.2-1.6 Msun, indicating that these OH/IR stars descend from solar-type stars. The objects in this sub-sample are further divided into two classes based on their SED characteristics: 11 objects have SEDs that are well matched by models invoking dust envelopes extending from a few stellar radii and outwards, while 6 objects are better modelled as having detached dust envelopes with inner radii in the range 200-600 au and warmer central stars. The former objects have periodic variability, while the latter objects are predominantly non-periodic. The median gas-mass-loss rate, gas terminal expansion velocity, gas-to-dust mass ratio, and circumstellar 12CO/13CO abundance ratio have been estimated to be 2x10{-5} Msun/yr, 18 km/s, 200 (excluding the sources with detached dust envelopes, which show markedly lower gas-to-dust ratios), and 5, respectively, for the inner-Galactic-Bulge objects. The inner-Galactic-Bulge OH/IR stars studied here constitute an excellent sample of equidistant objects for the purpose of understanding the evolution of the mass-loss-rate characteristics at the tip of the AGB., Comment: 32 pages, 17 figures
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- 2022
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115. A Chemical Map of the Outbursting V883 Ori system: Vertical and Radial Structures
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Ruiz-Rodriguez, D. A., Williams, J. P., Kastner, J. H., Cieza, L., Leemker, M., and Principe, D. A.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the first results of a pilot program to conduct an Atacama Large Millimeter/submillimeter Array (ALMA) Band 6 (211-275 GHz) spectral line study of young stellar objects (YSO) that are undergoing rapid accretion episodes, i.e. FU Ori objects (FUors). Here, we report on molecular emission line observations of the FUor system, V883 Ori. In order to image the FUor object with full coverage from ~0.5 arcsec to the map size of ~30 arcsec, i.e. from disc to outflow scales, we combine the ALMA main array (the 12-m array) with the Atacama Compact Array (7-m array) and the total power (TP) array. We detect HCN, HCO$^{+}$, CH$_{3}$OH, SO, DCN, and H$_{2}$CO emissions with most of these lines displaying complex kinematics. From PV diagrams, the detected molecules HCN, HCO$^{+}$, CH$_{3}$OH, DCN, SO, and H$_{2}$CO probe a Keplerian rotating disc in a direction perpendicular to the large-scale outflow detected previously with the $^{12}$CO and $^{13}$CO lines. Additionally, HCN and HCO$^{+}$ reveal kinematic signatures of infall motion. The north outflow is seen in HCO$^{+}$, H$_{2}$CO, and SO emissions. Interestingly, HCO$^{+}$ emission reveals a pronounced inner depression or "hole" with a size comparable to the radial extension estimated for the CH$_{3}$OH and 230 GHz continuum. The inner depression in the integrated HCO$^{+}$ intensity distribution of V883 Ori is most likely the result of optical depth effects, wherein the optically thick nature of the HCO$^{+}$ and continuum emission towards the innermost parts of V883 Ori can result in a continuum subtraction artifact in the final HCO$^{+}$ flux level.
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- 2022
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116. R-MelNet: Reduced Mel-Spectral Modeling for Neural TTS
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Kastner, Kyle and Courville, Aaron
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Computer Science - Sound ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
This paper introduces R-MelNet, a two-part autoregressive architecture with a frontend based on the first tier of MelNet and a backend WaveRNN-style audio decoder for neural text-to-speech synthesis. Taking as input a mixed sequence of characters and phonemes, with an optional audio priming sequence, this model produces low-resolution mel-spectral features which are interpolated and used by a WaveRNN decoder to produce an audio waveform. Coupled with half precision training, R-MelNet uses under 11 gigabytes of GPU memory on a single commodity GPU (NVIDIA 2080Ti). We detail a number of critical implementation details for stable half precision training, including an approximate, numerically stable mixture of logistics attention. Using a stochastic, multi-sample per step inference scheme, the resulting model generates highly varied audio, while enabling text and audio based controls to modify output waveforms. Qualitative and quantitative evaluations of an R-MelNet system trained on a single speaker TTS dataset demonstrate the effectiveness of our approach.
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- 2022
117. Open-source FPGA-ML codesign for the MLPerf Tiny Benchmark
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Borras, Hendrik, Di Guglielmo, Giuseppe, Duarte, Javier, Ghielmetti, Nicolò, Hawks, Ben, Hauck, Scott, Hsu, Shih-Chieh, Kastner, Ryan, Liang, Jason, Meza, Andres, Muhizi, Jules, Nguyen, Tai, Roy, Rushil, Tran, Nhan, Umuroglu, Yaman, Weng, Olivia, Yokuda, Aidan, and Blott, Michaela
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Computer Science - Machine Learning ,Computer Science - Hardware Architecture - Abstract
We present our development experience and recent results for the MLPerf Tiny Inference Benchmark on field-programmable gate array (FPGA) platforms. We use the open-source hls4ml and FINN workflows, which aim to democratize AI-hardware codesign of optimized neural networks on FPGAs. We present the design and implementation process for the keyword spotting, anomaly detection, and image classification benchmark tasks. The resulting hardware implementations are quantized, configurable, spatial dataflow architectures tailored for speed and efficiency and introduce new generic optimizations and common workflows developed as a part of this work. The full workflow is presented from quantization-aware training to FPGA implementation. The solutions are deployed on system-on-chip (Pynq-Z2) and pure FPGA (Arty A7-100T) platforms. The resulting submissions achieve latencies as low as 20 $\mu$s and energy consumption as low as 30 $\mu$J per inference. We demonstrate how emerging ML benchmarks on heterogeneous hardware platforms can catalyze collaboration and the development of new techniques and more accessible tools., Comment: 15 pages, 7 figures, Contribution to 3rd Workshop on Benchmarking Machine Learning Workloads on Emerging Hardware (MLBench) at 5th Conference on Machine Learning and Systems (MLSys)
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- 2022
118. Bayesian modeling and clustering for spatio-temporal areal data: An application to Italian unemployment
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Mozdzen, Alexander, Cremaschi, Andrea, Cadonna, Annalisa, Guglielmi, Alessandra, and Kastner, Gregor
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Statistics - Methodology - Abstract
Spatio-temporal areal data can be seen as a collection of time series which are spatially correlated according to a specific neighboring structure. Incorporating the temporal and spatial dimension into a statistical model poses challenges regarding the underlying theoretical framework as well as the implementation of efficient computational methods. We propose to include spatio-temporal random effects using a conditional autoregressive prior, where the temporal correlation is modeled through an autoregressive mean decomposition and the spatial correlation by the precision matrix inheriting the neighboring structure. Their joint distribution constitutes a Gaussian Markov random field, whose sparse precision matrix enables the usage of efficient sampling algorithms. We cluster the areal units using a nonparametric prior, thereby learning latent partitions of the areal units. The performance of the model is assessed via an application to study regional unemployment patterns in Italy. When compared to other spatial and spatio-temporal competitors, the proposed model shows more precise estimates and the additional information obtained from the clustering allows for an extended economic interpretation of the unemployment rates of the Italian provinces.
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- 2022
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119. Forecasting macroeconomic data with Bayesian VARs: Sparse or dense? It depends!
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Gruber, Luis and Kastner, Gregor
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Economics - Econometrics ,Statistics - Applications ,Statistics - Methodology - Abstract
Vector autogressions (VARs) are widely applied when it comes to modeling and forecasting macroeconomic variables. In high dimensions, however, they are prone to overfitting. Bayesian methods, more concretely shrinkage priors, have shown to be successful in improving prediction performance. In the present paper, we introduce the semi-global framework, in which we replace the traditional global shrinkage parameter with group-specific shrinkage parameters. We show how this framework can be applied to various shrinkage priors, such as global-local priors and stochastic search variable selection priors. We demonstrate the virtues of the proposed framework in an extensive simulation study and in an empirical application forecasting data of the US economy. Further, we shed more light on the ongoing ``Illusion of Sparsity'' debate, finding that forecasting performances under sparse/dense priors vary across evaluated economic variables and across time frames. Dynamic model averaging, however, can combine the merits of both worlds.
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- 2022
120. CO Line Emission Surfaces and Vertical Structure in Mid-Inclination Protoplanetary Disks
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Law, Charles J., Crystian, Sage, Teague, Richard, Öberg, Karin I., Rich, Evan A., Andrews, Sean M., Bae, Jaehan, Flaherty, Kevin, Guzmán, Viviana V., Huang, Jane, Ilee, John D., Kastner, Joel H., Loomis, Ryan A., Long, Feng, Pérez, Laura M., Pérez, Sebastián, Qi, Chunhua, Rosotti, Giovanni P., Ruíz-Rodríguez, Dary, Tsukagoshi, Takashi, and Wilner, David J.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
High spatial resolution CO observations of mid-inclination (30-75{\deg}) protoplanetary disks offer an opportunity to study the vertical distribution of CO emission and temperature. The asymmetry of line emission relative to the disk major axis allows for a direct mapping of the emission height above the midplane, and for optically-thick, spatially-resolved emission in LTE, the intensity is a measure of the local gas temperature. Our analysis of ALMA archival data yields CO emission surfaces, dynamically-constrained stellar host masses, and disk atmosphere gas temperatures for the disks around: HD 142666, MY Lup, V4046 Sgr, HD 100546, GW Lup, WaOph 6, DoAr 25, Sz 91, CI Tau, and DM Tau. These sources span a wide range in stellar masses (0.50-2.10 M$_{\odot}$), ages (${\sim}$0.3-23 Myr), and CO gas radial emission extents (${\approx}$200-1000 au). This sample nearly triples the number of disks with mapped emission surfaces and confirms the wide diversity in line emitting heights ($z/r\approx0.1$ to ${\gtrsim}0.5$) hinted at in previous studies. We compute radial and vertical CO gas temperature distributions for each disk. A few disks show local temperature dips or enhancements, some of which correspond to dust substructures or the proposed locations of embedded planets. Several emission surfaces also show vertical substructures, which all align with rings and gaps in the millimeter dust. Combining our sample with literature sources, we find that CO line emitting heights weakly decline with stellar mass and gas temperature, which, despite large scatter, is consistent with simple scaling relations. We also observe a correlation between CO emission height and disk size, which is due to the flared structure of disks. Overall, CO emission surfaces trace ${\approx}2$-$5\times$ gas pressure scale heights (H$_{\rm{g}}$) and could potentially be calibrated as empirical tracers of H$_{\rm{g}}$., Comment: 31 pages, 17 figures, accepted for publication in ApJ. Image cubes available at https://zenodo.org/record/6410045
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- 2022
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121. On Mach’s Principle in Entropic Gravity
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A. Schlatter and R. E. Kastner
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transaction ,spacetime ,entropic gravity ,inertial frame ,Mach’s principle ,Mathematics ,QA1-939 - Abstract
The question of where the inertial properties of matter come from has been open for a long time. Isaac Newton considered inertia an intrinsic property of matter. Ernst Mach held a different view whereby the inertia of a body comes from its interaction with the rest of the universe. This idea is known today as Mach’s principle. We discuss Mach’s principle based on transactional gravity, the recently developed connection of entropic gravity to the physics of quantum events, induced by transactions. It is shown that Mach’s principle holds and that there is a fundamental relation between the gravitational constant G and the total mass in the causal universe. This relationship, derived by means of entropic principles, is rigorously proven.
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- 2024
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122. Concept Paper for a Digital Expert: Systematic Derivation of (Causal) Bayesian Networks Based on Ontologies for Knowledge-Based Production Steps
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Manja Mai-Ly Pfaff-Kastner, Ken Wenzel, and Steffen Ihlenfeldt
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ontology ,ontology-based ,bayesian network ,causal graph ,digital expert ,basic formal ontology (BFO) ,Computer engineering. Computer hardware ,TK7885-7895 - Abstract
Despite increasing digitalization and automation, complex production processes often require human judgment/decision-making adaptability. Humans can abstract and transfer knowledge to new situations. People in production are an irreplaceable resource. This paper presents a new concept for digitizing human expertise and their ability to make knowledge-based decisions in the production area based on ontologies and causal Bayesian networks for further research. Dedicated approaches for the ontology-based creation of Bayesian networks exist in the literature. Therefore, we first comprehensively analyze previous studies and summarize the approaches. We then add the causal perspective, which has often not been an explicit subject of consideration. We see a research gap in the systematic and structured approach to ontology-based generation of causal graphs (CGs). At the current state of knowledge, the semantic understanding of a domain formalized in an ontology can contribute to developing a generic approach to derive a CG. The ontology functions as a knowledge base by formally representing knowledge and experience. Causal inference calculations can mathematically imitate the human decision-making process under uncertainty. Therefore, a systematic ontology-based approach to building a CG can allow digitizing the human ability to make decisions based on experience and knowledge.
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- 2024
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123. The role of nature's contributions to people in sustaining international trade of agricultural products
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Alexandra Marques, Aletta Bonn, Antonio J. Castro, Abhishek Chaudhary, María R. Felipe‐Lucia, Thomas Kastner, Thomas Koellner, Kira Lancker, Laura Lopez Hoffman, Carsten Meyer, Stephan Pfister, Gabriela Rabeschini, Louise Willemen, and Catharina J. E. Schulp
- Subjects
dependencies ,ecosystem services ,international agricultural trade ,Nature's contributions to people (NCP) ,supply chains ,telecoupling ,Human ecology. Anthropogeography ,GF1-900 ,Ecology ,QH540-549.5 - Abstract
Abstract Nature's contributions to people (NCP) are essential for the production and trade of agricultural, forestry and fishery commodities. Often, there is a spatial disconnect between consumers and the natural systems where the commodities are produced. Traded agricultural products are therefore dependent on nature and NCP in their region of origin. The dependencies of agricultural products on NCP are, however, insufficiently recognised by consumers and are rarely considered in global environmental governance and trade policies along value chains. Here, we synthesise studies highlighting dependencies of agricultural products on NCP in their origin locations to identify opportunities and challenges in quantifying their contribution in sustaining trade flows. We suggest three methodological steps for quantifying NCP dependencies in international agricultural trade: spatial mapping of NCP supply and demand, linking NCP to agricultural trade flows, and tracing trade flows. Each methodological step requires further development and harmonisation to enable a complete accounting of how international agricultural trade depends on NCP. Given the lack of knowledge and data on how NCP support agricultural trade, social and environmental trade‐offs of natural resource management are currently hard to quantify. Quantifying the role of NCP dependencies of traded agricultural products can support their sustainable management, contribute to supply chain accountability and serve as input to sustainable natural resource governance and foster responsibility and equity in supply chains. Read the free Plain Language Summary for this article on the Journal blog.
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- 2024
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124. PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
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Abdallah Gaballa, Anneli Gebhardt-Wolf, Bastian Krenz, Greta Mattavelli, Mara John, Giacomo Cossa, Silvia Andreani, Christina Schülein-Völk, Francisco Montesinos, Raphael Vidal, Carolin Kastner, Carsten P. Ade, Burkhard Kneitz, Georg Gasteiger, Peter Gallant, Mathias Rosenfeldt, Angela Riedel, and Martin Eilers
- Subjects
Science - Abstract
Abstract In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase progression and escape from immune surveillance. Here we show that MYC in PDAC cells is needed for the recruitment of the PAF1c transcription elongation complex to RNA polymerase and that depletion of CTR9, a PAF1c subunit, enables long-term survival of PDAC-bearing mice. PAF1c is largely dispensable for normal proliferation and regulation of MYC target genes. Instead, PAF1c limits DNA damage associated with S-phase progression by being essential for the expression of long genes involved in replication and DNA repair. Surprisingly, the survival benefit conferred by CTR9 depletion is not due to DNA damage, but to T-cell activation and restoration of immune surveillance. This is because CTR9 depletion releases RNA polymerase and elongation factors from the body of long genes and promotes the transcription of short genes, including MHC class I genes. The data argue that functionally distinct gene sets compete for elongation factors and directly link MYC-driven S-phase progression to tumor immune evasion.
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- 2024
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125. Monitorização de transplante cardíaco usando análises do eletrograma intracavitário
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BROFMAN Paulo Roberto S., COSTA Iseu Affonso da, LOURES Danton R. da Rocha, SCHREIER G., KASTNER P., HUTTEN H., and SCHALDACH Max
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Transplante cardíaco ,Rejeição de enxerto/diagnóstico ,Eletrodiagnóstico/métodos ,Marcapasso artificial ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Uma série de registros do eletrograma intracavitário tem sido utilizada para monitorização não invasiva da rejeição em pacientes transplantados usando um marcapasso de dupla câmara e eletrodos endocavitários revestidos com estrutura fractal. Os sinais têm sido avaliados usando o sistema CHARM (Computerized Heart Acute Rejection Monitoring _ sistema computadorizado para monitorização da rejeição cardíaca aguda). Os relatórios obtidos com este sistema contêm curvas com parâmetros sensíveis à rejeição, que demonstram uma boa correlação com a clínica e os resultados das biópsias convencionais. A monitorização a longo prazo, usando estas análises, mostrou ser uma ferramenta valiosa no acompanhamento destes pacientes.
- Published
- 1997
126. Suppression of Quasiperiodicity in Circle Maps with Quenched Disorder
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Müller-Bender, David, Kastner, Johann Luca, and Radons, Günter
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Nonlinear Sciences - Chaotic Dynamics ,Condensed Matter - Disordered Systems and Neural Networks ,Mathematics - Dynamical Systems ,37E10, 37H15, 82C44 - Abstract
We show that introducing quenched disorder into a circle map leads to the suppression of quasiperiodic behavior in the limit of large system sizes. Specifically, for most parameters the fraction of disorder realizations showing quasiperiodicity decreases with the system size and eventually vanishes in the limit of infinite size, where almost all realizations show mode-locking. Consequently, in this limit, and in strong contrast to standard circle maps, almost the whole parameter space corresponding to invertible dynamics consists of Arnold tongues., Comment: 7 pages, 4 figures; minor changes due to review process
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- 2022
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127. Long-range Kitaev chain in a thermal bath: Analytic techniques for time-dependent systems and environments
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King, Emma C., Kastner, Michael, and Kriel, Johannes N.
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Quantum Physics ,Condensed Matter - Quantum Gases ,Condensed Matter - Statistical Mechanics - Abstract
We construct and solve a "minimal model" with which nonequilibrium phenomena in many-body open quantum systems can be studied analytically under time-dependent parameter changes in the system and/or the bath. Coupling a suitable configuration of baths to a Kitaev chain, we self-consistently derive a Lindblad master equation which, at least in the absence of explicit time dependencies, leads to thermalization. Using the method of Third Quantization we derive time-evolution equations for the correlation matrix, which we relate to the occupation of the system's quasiparticle modes. These results permit analytic and efficient numeric descriptions of the nonequilibrium dynamics of open Kitaev chains under a wide range of driving protocols, which in turn facilitate the investigation of the interplay between bath-induced dissipation and the generation of coherent excitations by nonadiabatic driving. We advertise this minimal model of maximum simplicity for the study of finite-temperature generalizations of Kibble-Zurek ramps, Floquet physics, and many other nonequilibrium protocols of quantum many-body systems driven by time-varying parameters and/or temperatures., Comment: 12 pages, 4 figures; companion paper to "Universal cooling dynamics towards a quantum critical point" by the same authors and submitted on the same day
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- 2022
128. Universal cooling dynamics toward a quantum critical point
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King, Emma C., Kriel, Johannes N., and Kastner, Michael
- Subjects
Quantum Physics ,Condensed Matter - Quantum Gases ,Condensed Matter - Statistical Mechanics - Abstract
We investigate the loss of adiabaticity when cooling a many-body quantum system from an initial thermal state toward a quantum critical point. The excitation density, which quantifies the degree of adiabaticity of the dynamics, is found to obey scaling laws in the cooling velocity as well as in the initial and final temperatures of the cooling protocol. The scaling laws are universal, governed by the critical exponents of the quantum phase transition. The validity of these statements is shown analytically for a Kitaev quantum wire coupled to Markovian baths and argued to be valid under rather general conditions. Our results establish that quantum critical properties can be probed dynamically at finite temperature, without even varying the control parameter of the quantum phase transition., Comment: 6+5 pages, 2+3 figures; companion paper to arXiv:2204.07594
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- 2022
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129. Nearby Young Stars and Young Moving Groups
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Kastner, Joel H. and Principe, David A.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
The past two decades have seen dramatic progress in our knowledge of the population of stars of age $\lesssim$150 Myr that lie within $\sim$100 pc of the Sun. Most such stars are found in loose kinematic groups ("nearby young moving groups"; NYMGs). The proximity of NYMGs and their members facilitates studies of the X-ray properties of coeval groups of pre-main sequence (pre-MS) stars as well as of individual pre-MS systems. In this review, we focus on how NYMG X-ray studies provide unique insight into the early evolution of stellar magnetic activity, the X-ray signatures of accretion, and the irradiation and dissipation of protoplanetary disks by high-energy photons originating with their host pre-MS stars. We discuss the likely impacts of the next generation of X-ray observing facilities on these aspects of the study of NYMGs and their members., Comment: To appear in Springer's "Handbook of X-ray and Gamma-ray Astrophysics" (eds. A. Santangelo and C. Bambi), Section "The Sun, Stars & Planets" (eds. G. Micela & B. Stelzer)
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- 2022
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130. C to Checked C by 3C
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Machiry, Aravind, Kastner, John, McCutchen, Matt, Eline, Aaron, Headley, Kyle, and Hicks, Michael
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Computer Science - Programming Languages ,Computer Science - Cryptography and Security ,Computer Science - Software Engineering - Abstract
Owing to the continued use of C (and C++), spatial safety violations (e.g., buffer overflows) still constitute one of today's most dangerous and prevalent security vulnerabilities. To combat these violations, Checked C extends C with bounds-enforced checked pointer types. Checked C is essentially a gradually typed spatially safe C - checked pointers are backwards-binary compatible with legacy pointers, and the language allows them to be added piecemeal, rather than necessarily all at once, so that safety retrofitting can be incremental. This paper presents a semi-automated process for porting a legacy C program to Checked C. The process centers on 3C, a static analysis-based annotation tool. 3C employs two novel static analysis algorithms - typ3c and boun3c - to annotate legacy pointers as checked pointers, and to infer array bounds annotations for pointers that need them. 3C performs a root cause analysis to direct a human developer to code that should be refactored; once done, 3C can be re-run to infer further annotations (and updated root causes). Experiments on 11 programs totaling 319KLoC show 3C to be effective at inferring checked pointer types, and experience with previously and newly ported code finds 3C works well when combined with human-driven refactoring.
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- 2022
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131. R2-D2: Roman and Rubin -- From Data to Discovery
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Gezari, Suvi, Bentz, Misty, De, Kishalay, French, K. Decker, Meisner, Aaron, Ntampaka, Michelle, Jedicke, Robert, Patel, Ekta, Perley, Daniel, Sanderson, Robyn, Aganze, Christian, Andreoni, Igor, Bell, Eric F., Berger, Edo, Dell'Antonio, Ian, Foley, Ryan, Hsieh, Henry, Kasliwal, Mansi, Kastner, Joel, Kilpatrick, Charles D., Kirkpatrick, J. Davy, Lam, Casey, Meech, Karen, Minniti, Dante, Nadler, Ethan O., Nagai, Daisuke, Pierel, Justin, Shivaei, Irene, Street, Rachel, Tollerud, Erik J., and Williams, Benjamin
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The NASA Nancy Grace Roman Space Telescope (Roman) and the Vera C. Rubin Observatory Legacy Survey of Space and Time (Rubin), will transform our view of the wide-field sky, with similar sensitivities, but complementary in wavelength, spatial resolution, and time domain coverage. Here we present findings from the AURA Roman+Rubin Synergy Working group, charged by the STScI and NOIRLab Directors to identify frontier science questions in General Astrophysics, beyond the well-covered areas of Dark Energy and Cosmology, that can be uniquely addressed with Roman and Rubin synergies in observing strategy, data products and archiving, joint analysis, and community engagement. This analysis was conducted with input from the community in the form of brief (1-2 paragraph) "science pitches" (see Appendix), and testimony from "outside experts" (included as co-authors). We identify a rich and broad landscape of potential discoveries catalyzed by the combination of exceptional quality and quantity of Roman and Rubin data, and summarize implementation requirements that would facilitate this bounty of additional science with coordination of survey fields, joint coverage of the Galactic plane, bulge, and ecliptic, expansion of General Investigator and Target of Opportunity observing modes, co-location of Roman and Rubin data, and timely distribution of data, transient alerts, catalogs, value-added joint analysis products, and simulations to the broad astronomical community., Comment: 29 pages, 12 figures, Table of Implementation Recommendations, Appendix of Community Science Pitches, AURA-commissioned whitepaper submitted to the Director of STScI (Ken Sembach) and the Director of NOIRLab (Pat McCarthy)
- Published
- 2022
132. Clean quantum point contacts in an InAs quantum well grown on a lattice-mismatched InP substrate
- Author
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Hsueh, Connie L., Sriram, Praveen, Wang, Tiantian, Thomas, Candice, Gardner, Geoffrey, Kastner, Marc A., Manfra, Michael J., and Goldhaber-Gordon, David
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Strong spin-orbit coupling, the resulting large $g$ factor, and small effective mass make InAs an attractive material platform for inducing topological superconductivity. The surface Fermi level pinning in the conduction band enables highly transparent ohmic contact without excessive doping. We investigate electrostatically defined quantum point contacts (QPCs) in a deep-well InAs two-dimensional electron gas. Despite the 3.3% lattice mismatch between the InAs quantum well and the InP substrate, we report clean QPCs with up to eight pronounced quantized conductance plateaus at zero magnetic field. Source-drain dc bias spectroscopy reveals a harmonic confinement potential with a nearly $5$ meV subband spacing. We find a many-body exchange interaction enhancement for the out-of-plane $g$ factor $|g_{\perp}^*| = 27 \pm 1$, whereas the in-plane $g$ factor is isotropic $|g^*_{x}| = |g^*_{y}| = 12 \pm 2$, close to the bulk value for InAs., Comment: Main text (8 pages, 5 figures), Supplemental Material (10 pages, 10 figures)
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- 2022
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133. Isadora: automated information-flow property generation for hardware security verification
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Deutschbein, Calvin, Meza, Andres, Restuccia, Francesco, Kastner, Ryan, and Sturton, Cynthia
- Published
- 2023
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134. A Comparison of Fixed and Incrementing Reinforcement Durations during Schedule Thinning for Individuals with Escape-Maintained Problem Behavior
- Author
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Kastner, Kendall M., Tiger, Jeffrey H., and Gifford, Margaret R.
- Abstract
As a treatment for escape-maintained problem behavior, differential reinforcement of alternative behavior (DRA) is typically initiated by reinforcing compliance on a dense reinforcement schedule. This work schedule is then progressively thinned such that the individual is required to complete more work, up to some socially acceptable terminal goal, before earning access to reinforcement. Two variations of this procedure appear in the literature but have not been compared directly. One variation involves maintaining a fixed reinforcement duration as the work requirements increase; the other involves increasing the reinforcement duration incrementally, coinciding with increases in work requirements. The current study compared these procedures with three children with intellectual and developmental disabilities who exhibited problem behavior maintained by escape from instruction. Schedule thinning evoked less problem behavior when reinforcement durations increased incrementally for all three participants. These reductions in problem behavior allowed more rapid progress toward terminal goals.
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- 2023
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135. Blended Learning: Moving beyond the Thread Quality of Blended Learning and Instructor Experiences
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Kastner, Jenine A.
- Abstract
In higher education, teaching and learning are undergoing a variety of innovations that involve the use of technology through blended learning. This pedagogical approach has been popular and expanding quickly in institutions internationally with a shift in focus from the technological aspects of learning management systems to theoretical frameworks to enhance practices in a move from traditional to blended learning. This study explores the benefits, barriers, and professional development practices utilized in higher education settings to implement blended learning classes. This quantitative research analyzed the practices of blended learning as an approach to teaching and learning in higher education through survey research. This study includes additional insight and understanding of the current and future trends regarding how to surpass these barriers and enhance the overall practices of blended learning. Higher education institutions can utilize this blended learning research to develop comprehensive guidelines and increase collaboration and innovation to improve practices and move beyond the threaded discussions. This study concluded that instructors rate the quality of the educational experience in their blended learning courses as superior or very superior compared to the traditional face-to-face format of instruction and that a lack of professional development is impacting the growth and effectiveness of the blended learning environment in higher education.
- Published
- 2020
136. An Analysis of Approximation Algorithms for Iterated Stochastic Integrals and a Julia and MATLAB Simulation Toolbox
- Author
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Kastner, Felix and Rößler, Andreas
- Subjects
Mathematics - Numerical Analysis ,Computer Science - Mathematical Software ,Mathematics - Probability ,60H05, 60H10, 65C30 - Abstract
For the approximation and simulation of twofold iterated stochastic integrals and the corresponding L\'{e}vy areas w.r.t. a multi-dimensional Wiener process, we review four algorithms based on a Fourier series approach. Especially, the very efficient algorithm due to Wiktorsson and a newly proposed algorithm due to Mrongowius and R\"ossler are considered. To put recent advances into context, we analyse the four Fourier-based algorithms in a unified framework to highlight differences and similarities in their derivation. A comparison of theoretical properties is complemented by a numerical simulation that reveals the order of convergence for each algorithm. Further, concrete instructions for the choice of the optimal algorithm and parameters for the simulation of solutions for stochastic (partial) differential equations are given. Additionally, we provide advice for an efficient implementation of the considered algorithms and incorporated these insights into an open source toolbox that is freely available for both Julia and MATLAB programming languages. The performance of this toolbox is analysed by comparing it to some existing implementations, where we observe a significant speed-up.
- Published
- 2022
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137. The ODYSSEUS Survey. Motivation and First Results: Accretion, Ejection, and Disk Irradiation of CVSO 109
- Author
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Espaillat, C. C., Herczeg, G. J., Thanathibodee, T., Pittman, C., Calvet, N., Arulanantham, N., France, K., Serna, Javier, Hernandez, J., Kospal, A., Walter, F. M., Frasca, A., Fischer, W. J., Johns-Krull, C. M., Schneider, P. C., Robinson, C., Edwards, Suzan, Abraham, P., Fang, Min, Erkal, J., Manara, C. F., Alcala, J. M., Alecian, E., Alexander, R. D., Alonso-Santiago, J., Antoniucci, Simone, Ardila, David R., Banzatti, Andrea, Benisty, M., Bergin, Edwin A., Biazzo, Katia, Briceno, Cesar, Campbell-White, Justyn, Cleeves, L. Ilsedore, Coffey, Deirdre, Eisloffel, Jochen, Facchini, Stefano, Fedele, D., Fiorellino, Eleonora, Froebrich, Dirk, Gangi, Manuele, Giannini, Teresa, Grankin, K., Gunther, Hans Moritz, Guo, Zhen, Hartmann, Lee, Hillenbrand, Lynne A., Hinton, P. C., Kastner, Joel H., Koen, Chris, Mauco, K., Mendigutia, I., Nisini, B., Panwar, Neelam, Principe, D. A., Robberto, Massimo, Sicilia-Aguilar, A., Valenti, Jeff A., Wendeborn, J., Williams, Jonathan P., Xu, Ziyan, and Yadav, R. K.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
The Hubble UV Legacy Library of Young Stars as Essential Standards (ULLYSES) Director's Discretionary Program of low-mass pre-main-sequence stars, coupled with forthcoming data from ALMA and JWST, will provide the foundation to revolutionize our understanding of the relationship between young stars and their protoplanetary disks. A comprehensive evaluation of the physics of disk evolution and planet formation requires understanding the intricate relationships between mass accretion, mass outflow, and disk structure. Here we describe the Outflows and Disks around Young Stars: Synergies for the Exploration of ULLYSES Spectra (ODYSSEUS) Survey and present initial results of the classical T Tauri Star CVSO 109 in Orion OB1b as a demonstration of the science that will result from the survey. ODYSSEUS will analyze the ULLYSES spectral database, ensuring a uniform and systematic approach in order to (1) measure how the accretion flow depends on the accretion rate and magnetic structures, (2) determine where winds and jets are launched and how mass-loss rates compare with accretion, and (3) establish the influence of FUV radiation on the chemistry of the warm inner regions of planet-forming disks. ODYSSEUS will also acquire and provide contemporaneous observations at X-ray, optical, NIR, and millimeter wavelengths to enhance the impact of the ULLYSES data. Our goal is to provide a consistent framework to accurately measure the level and evolution of mass accretion in protoplanetary disks, the properties and magnitudes of inner-disk mass loss, and the influence of UV radiation fields that determine ionization levels and drive disk chemistry., Comment: accepted to ApJ
- Published
- 2022
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138. Measured potential profile in a quantum anomalous Hall system suggests bulk-dominated current flow
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Rosen, Ilan T., Andersen, Molly P., Rodenbach, Linsey K., Tai, Lixuan, Zhang, Peng, Wang, Kang L., Kastner, M. A., and Goldhaber-Gordon, David
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Ideally, quantum anomalous Hall systems should display zero longitudinal resistance. Yet in experimental quantum anomalous Hall systems elevated temperature can make the longitudinal resistance finite, indicating dissipative flow of electrons. Here, we show that the measured potentials at multiple locations within a device at elevated temperature are well-described by solution of Laplace's equation, assuming spatially-uniform conductivity, suggesting non-equilibrium current flows through the two-dimensional bulk. Extrapolation suggests that at even lower temperatures current may still flow primarily through the bulk rather than, as had been assumed, through edge modes. An argument for bulk current flow previously applied to quantum Hall systems supports this picture., Comment: 6 pages, 4 figures, plus supplemental materials
- Published
- 2021
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139. MIDI-DDSP: Detailed Control of Musical Performance via Hierarchical Modeling
- Author
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Wu, Yusong, Manilow, Ethan, Deng, Yi, Swavely, Rigel, Kastner, Kyle, Cooijmans, Tim, Courville, Aaron, Huang, Cheng-Zhi Anna, and Engel, Jesse
- Subjects
Computer Science - Sound ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
Musical expression requires control of both what notes are played, and how they are performed. Conventional audio synthesizers provide detailed expressive controls, but at the cost of realism. Black-box neural audio synthesis and concatenative samplers can produce realistic audio, but have few mechanisms for control. In this work, we introduce MIDI-DDSP a hierarchical model of musical instruments that enables both realistic neural audio synthesis and detailed user control. Starting from interpretable Differentiable Digital Signal Processing (DDSP) synthesis parameters, we infer musical notes and high-level properties of their expressive performance (such as timbre, vibrato, dynamics, and articulation). This creates a 3-level hierarchy (notes, performance, synthesis) that affords individuals the option to intervene at each level, or utilize trained priors (performance given notes, synthesis given performance) for creative assistance. Through quantitative experiments and listening tests, we demonstrate that this hierarchy can reconstruct high-fidelity audio, accurately predict performance attributes for a note sequence, independently manipulate the attributes of a given performance, and as a complete system, generate realistic audio from a novel note sequence. By utilizing an interpretable hierarchy, with multiple levels of granularity, MIDI-DDSP opens the door to assistive tools to empower individuals across a diverse range of musical experience., Comment: Accepted by International Conference on Learning Representations (ICLR) 2022
- Published
- 2021
140. Sampling Molecular Gas in the Helix Planetary Nebula: Variation in HNC/HCN with UV Flux
- Author
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Bublitz, Jesse, Kastner, Joel H., Hily-Blant, Pierre, Forveille, Thierry, Santander-García, Miguel, Alcolea, Javier, and Bujarrabal, Valentin
- Subjects
Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Observations of molecular clouds, prestellar cores, and protoplanetary disks have established that the HNC/HCN ratio may be a potent diagnostic of molecular gas physical conditions. The processes that govern the relative abundances of these molecules nevertheless remain poorly understood. We seek to exploit the wide range of UV irradiation strengths within the 1 pc diameter Helix planetary nebula to explore the potential role of UV radiation in driving HNC/HCN. We performed IRAM 30 m and APEX 12 m radio line observations across six positions within the Helix Nebula, making use of radiative transfer and photodissociation modeling codes to interpret the results for line intensities and line ratios in terms of the molecular gas properties. We have obtained the first detections of the plasma-embedded Helix molecular knots (globules) in HCN, HNC, HCO+, and other trace molecules. Analysis of the HNC/HCN integrated line intensity ratio reveals an increase with radial distance from the Helix central star. In the context of molecular line ratios of other planetary nebulae from the literature, the HNC/HCN ratio appears to be anticorrelated with UV emission over four orders of magnitude in incident flux. Models of the photodissociation regions within the Helix using the RADEX and Meudon codes reveal strong constraints on column density of the molecular gas, as well as pressure and temperature. Analysis of the molecular ion HCO+ across the Helix indicates that X-ray irradiation is likely driving HCO+ production in the outer regions of planetary nebulae, where photodissociation is limited, yet cold gas and ionized molecules are abundant. Although the observational results clearly indicate that UV irradiation is important in determining the HNC/HCN ratio, our PDR modeling indicates that the UV flux gradient alone cannot reproduce the observed variation of HNC/HCN across the Helix., Comment: 19 pages, 13 figures, 6 tables
- Published
- 2021
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141. Ice cage: new records and cryptic, isolated lineages in wingless snow flies (Diptera, Limoniidae: Chionea spp.) in German lower mountain ranges
- Author
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Klesser, Robert, Blick, Theo, Fritze, Michael-Andreas, Marten, Andreas, Hemauer, Michael, Kastner, Laura, Höfer, Hubert, Jäger, Gero, and Husemann, Martin
- Published
- 2024
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142. Gape‐limited invasive predator frequently kills avian prey that are too large to swallow
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Martin Kastner, Scott M. Goetz, Kayla M. Baker, Shane R. Siers, Eben H. Paxton, Melia G. Nafus, and Haldre S. Rogers
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body size ,Brown Treesnake ,foraging theory ,gape limitation ,predation success ,Ecology ,QH540-549.5 - Abstract
Abstract Gape‐limited predators (e.g., snakes, many fish) are not generally expected to pose a predation threat to prey that are too large for them to swallow. However, the extent to which snakes predate on prey that exceed their gape limitation remains largely unknown. We conducted the first study to investigate the influence of both prey and predator sizes on the frequency of ingestion success by snakes in a natural system. We combined survival monitoring of an avian prey species (Aplonis opaca) via radio‐telemetry with a survey of the size distribution of their major predator (Boiga irregularis) on Guam. This allowed us to assess (1) the frequency of unsuccessful ingestion by the predator, (2) whether the size of the prey predicts ingestion success, (3) whether the size of the predator predicts ingestion success, and (4) the relationship between prey and predator sizes in successful ingestion attempts. We found that nearly half (47.95%) of ingestion attempts by snakes on fledgling birds were unsuccessful, and no instances where unsuccessful ingestion caused the mortality of the snake. Attempts to consume smaller fledglings were as likely to be unsuccessful as attempts to swallow larger fledglings. However, snakes that successfully ingested fledglings were among the largest snakes in the population, and larger than average conspecifics attracted to endothermic prey. The smallest snakes that successfully ingested fledglings attained remarkably high relative prey mass values for their species, consuming prey weighing up to 79.9% of their own mass. Our study indicates that B. irregularis routinely predate prey that are too large for them to successfully ingest, which causes mortality to the prey but poses little risk to the predator. The potential reward for snakes in consuming oversized prey may outweigh the inherent risks, while instances of predation that do not result in consumption may have considerable impacts on prey populations.
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- 2024
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143. Automating hardware security property generation
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Kastner, Ryan, Restuccia, Francesco, Meza, Andres, Ray, Sayak, Fung, Jason, and Sturton, Cynthia
- Published
- 2022
144. A high-tech, low-cost, Internet of Things surfboard fin for coastal citizen science, outreach, and education
- Author
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Bresnahan, Philip, Cyronak, Tyler, Brewin, Robert JW, Andersson, Andreas, Wirth, Taylor, Martz, Todd, Courtney, Travis, Hui, Nathan, Kastner, Ryan, Stern, Andrew, McGrain, Todd, Reinicke, Danica, Richard, Jon, Hammond, Katherine, and Waters, Shannon
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Earth Sciences ,Oceanography ,Life Below Water ,Coastal oceanography ,Citizen science ,Surfing ,Sea surface temperature ,Outreach ,Biological Sciences ,Biological sciences ,Earth sciences - Published
- 2022
145. Applications and Techniques for Fast Machine Learning in Science
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Deiana, Allison McCarn, Tran, Nhan, Agar, Joshua, Blott, Michaela, Di Guglielmo, Giuseppe, Duarte, Javier, Harris, Philip, Hauck, Scott, Liu, Mia, Neubauer, Mark S., Ngadiuba, Jennifer, Ogrenci-Memik, Seda, Pierini, Maurizio, Aarrestad, Thea, Bahr, Steffen, Becker, Jurgen, Berthold, Anne-Sophie, Bonventre, Richard J., Bravo, Tomas E. Muller, Diefenthaler, Markus, Dong, Zhen, Fritzsche, Nick, Gholami, Amir, Govorkova, Ekaterina, Hazelwood, Kyle J, Herwig, Christian, Khan, Babar, Kim, Sehoon, Klijnsma, Thomas, Liu, Yaling, Lo, Kin Ho, Nguyen, Tri, Pezzullo, Gianantonio, Rasoulinezhad, Seyedramin, Rivera, Ryan A., Scholberg, Kate, Selig, Justin, Sen, Sougata, Strukov, Dmitri, Tang, William, Thais, Savannah, Unger, Kai Lukas, Vilalta, Ricardo, Krosigk, Belinavon, Warburton, Thomas K., Flechas, Maria Acosta, Aportela, Anthony, Calvet, Thomas, Cristella, Leonardo, Diaz, Daniel, Doglioni, Caterina, Galati, Maria Domenica, Khoda, Elham E, Fahim, Farah, Giri, Davide, Hawks, Benjamin, Hoang, Duc, Holzman, Burt, Hsu, Shih-Chieh, Jindariani, Sergo, Johnson, Iris, Kansal, Raghav, Kastner, Ryan, Katsavounidis, Erik, Krupa, Jeffrey, Li, Pan, Madireddy, Sandeep, Marx, Ethan, McCormack, Patrick, Meza, Andres, Mitrevski, Jovan, Mohammed, Mohammed Attia, Mokhtar, Farouk, Moreno, Eric, Nagu, Srishti, Narayan, Rohin, Palladino, Noah, Que, Zhiqiang, Park, Sang Eon, Ramamoorthy, Subramanian, Rankin, Dylan, Rothman, Simon, Sharma, Ashish, Summers, Sioni, Vischia, Pietro, Vlimant, Jean-Roch, and Weng, Olivia
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Computer Science - Machine Learning ,Computer Science - Hardware Architecture ,Physics - Data Analysis, Statistics and Probability ,Physics - Instrumentation and Detectors - Abstract
In this community review report, we discuss applications and techniques for fast machine learning (ML) in science -- the concept of integrating power ML methods into the real-time experimental data processing loop to accelerate scientific discovery. The material for the report builds on two workshops held by the Fast ML for Science community and covers three main areas: applications for fast ML across a number of scientific domains; techniques for training and implementing performant and resource-efficient ML algorithms; and computing architectures, platforms, and technologies for deploying these algorithms. We also present overlapping challenges across the multiple scientific domains where common solutions can be found. This community report is intended to give plenty of examples and inspiration for scientific discovery through integrated and accelerated ML solutions. This is followed by a high-level overview and organization of technical advances, including an abundance of pointers to source material, which can enable these breakthroughs., Comment: 66 pages, 13 figures, 5 tables
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- 2021
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146. Clean ballistic quantum point contact in SrTiO$_3$
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Mikheev, Evgeny, Rosen, Ilan T., Kastner, Marc A., and Goldhaber-Gordon, David
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Two dimensional electron gases based on SrTiO$_3$ are an intriguing platform for exploring mesoscopic superconductivity combined with spin-orbit coupling, offering electrostatic tunability from insulator to metal to superconductor within a single material. So far, however, quantum effects in SrTiO$_3$ nanostructures have been complicated by disorder. Here we introduce a facile approach to achieving high mobility and patterning gate-tunable structures in SrTiO$_3$, and use it to demonstrate ballistic constrictions with clean normal state conductance quantization. Conductance plateaus show two-fold degeneracy that persists to magnetic fields of at least 5 T - far beyond what one would expect from the $g$-factor extracted at high fields - a potential signature of electron pairing extending outside the superconducting regime.
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- 2021
147. Objective Measures of Perceptual Audio Quality Reviewed: An Evaluation of Their Application Domain Dependence
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Torcoli, Matteo, Kastner, Thorsten, and Herre, Jürgen
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Electrical Engineering and Systems Science - Audio and Speech Processing ,Computer Science - Sound - Abstract
Over the past few decades, computational methods have been developed to estimate perceptual audio quality. These methods, also referred to as objective quality measures, are usually developed and intended for a specific application domain. Because of their convenience, they are often used outside their original intended domain, even if it is unclear whether they provide reliable quality estimates in this case. This work studies the correlation of well-known state-of-the-art objective measures with human perceptual scores in two different domains: audio coding and source separation. The following objective measures are considered: fwSNRseg, dLLR, PESQ, PEAQ, POLQA, PEMO-Q, ViSQOLAudio, (SI-)BSSEval, PEASS, LKR-PI, 2f-model, and HAAQI. Additionally, a novel measure (SI-SA2f) is presented, based on the 2f-model and a BSSEval-based signal decomposition. We use perceptual scores from 7 listening tests about audio coding and 7 listening tests about source separation as ground-truth data for the correlation analysis. The results show that one method (2f-model) performs significantly better than the others on both domains and indicate that the dataset for training the method and a robust underlying auditory model are crucial factors towards a universal, domain-independent objective measure.
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- 2021
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148. Sustainability Through Cognition Aware Safety Systems -- Next Level Human-Machine-Interaction
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Mangler, Juergen, Diwol, Konrad, Etz, Dieter, Rinderle-Ma, Stefanie, Ferscha, Alois, Reiner, Gerald, Kastner, Wolfgang, Bougain, Sebastien, Pollak, Christoph, and Haslgrübler, Michael
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Computer Science - Machine Learning ,D.2 ,H.4 ,J.6 - Abstract
Industrial Safety deals with the physical integrity of humans, machines and the environment when they interact during production scenarios. Industrial Safety is subject to a rigorous certification process that leads to inflexible settings, in which all changes are forbidden. With the progressing introduction of smart robotics and smart machinery to the factory floor, combined with an increasing shortage of skilled workers, it becomes imperative that safety scenarios incorporate a flexible handling of the boundary between humans, machines and the environment. In order to increase the well-being of workers, reduce accidents, and compensate for different skill sets, the configuration of machines and the factory floor should be dynamically adapted, while still enforcing functional safety requirements. The contribution of this paper is as follows: (1) We present a set of three scenarios, and discuss how industrial safety mechanisms could be augmented through dynamic changes to the work environment in order to decrease potential accidents, and thus increase productivity. (2) We introduce the concept of a Cognition Aware Safety System (CASS) and its architecture. The idea behind CASS is to integrate AI based reasoning about human load, stress, and attention with AI based selection of actions to avoid the triggering of safety stops. (3) And finally, we will describe the required performance measurement dimensions for a quantitative performance measurement model to enable a comprehensive (triple bottom line) impact assessment of CASS. Additionally we introduce a detailed guideline for expert interviews to explore the feasibility of the approach for given scenarios., Comment: 27 pages. 4 figures. 2 tables. pre-print journal paper. position paper
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- 2021
149. Junkyard Computing: Repurposing Discarded Smartphones to Minimize Carbon
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Switzer, Jennifer, Marcano, Gabriel, Kastner, Ryan, and Pannuto, Pat
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Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
1.5 billion smartphones are sold annually, and most are decommissioned less than two years later. Most of these unwanted smartphones are neither discarded nor recycled but languish in junk drawers and storage units. This computational stockpile represents a substantial wasted potential: modern smartphones have increasingly high-performance and energy-efficient processors, extensive networking capabilities, and a reliable built-in power supply. This project studies the ability to reuse smartphones as "junkyard computers." Junkyard computers grow global computing capacity by extending device lifetimes, which supplants the manufacture of new devices. We show that the capabilities of even decade-old smartphones are within those demanded by modern cloud microservices and discuss how to combine phones to perform increasingly complex tasks. We describe how current operation-focused metrics do not capture the actual carbon costs of compute. We propose Computational Carbon Intensity -- a performance metric that balances the continued service of older devices with the superlinear runtime improvements of newer machines. We use this metric to redefine device service lifetime in terms of carbon efficiency. We develop a cloudlet of reused Pixel 3A phones. We analyze the carbon benefits of deploying large, end-to-end microservice-based applications on these smartphones. Finally, we describe system architectures and associated challenges to scale to cloudlets with hundreds and thousands of smartphones.
- Published
- 2021
150. Expanding Bipolar X-ray Structure After the 2006 Eruption of RS Oph
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Montez Jr., R., Luna, G. J. M., Mukai, K., Sokoloski, J., and Kastner, J. H.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We report on the detection and analysis of extended X-ray emission by the {\it Chandra} X-ray Observatory stemming from the 2006 eruption of the recurrent novae RS Oph. The extended emission was detected 1254 and 1927 days after the start of the 2006 eruption and is consistent with a bipolar flow oriented in the east-west direction of the sky with opening angles of approximately $70^{\circ}$. The length of both lobes appeared to expand from 1.3 arcsec in 2009 to 2.0 arcsec in 2011, suggesting a projected expansion rate of $1.1\pm0.1 {\rm ~mas~day}^{-1}$ and an expansion velocity of $4600\ {\rm km~s}^{-1}\ (D/2.4\ {\rm kpc})$ in the plane of the sky. This expansion rate is consistent with previous estimates from optical and radio observations of material in a similar orientation. The X-ray emission does not show any evidence of cooling between 2009 and 2011, consistent with free expansion of the material. This discovery suggests that some mechanism collimates ejecta away from the equatorial plane, and that after that material passes through the red-giant wind, it expands freely into the cavity left by the 1985 eruption. We expect similar structures to arise from latest eruption and to expand into the cavity shaped by the 2006 eruption., Comment: 11 pages, 4 figures, submitted to ApJ and as a chapter to my memoir: thank you for your patience, or other ways to stop apologizing for being late
- Published
- 2021
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