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Background: Allograft lung ischemia-reperfusion injury (ALIRI) is a major cause of early primary graft dysfunction and poor long-term survival after lung transplantation (LTx); however, its pathogenesis has not been fully elucidated. Cell death is a mechanism underlying ALIRI. Cuproptosis is a recently discovered form of programmed cell death. To date, no studies have been conducted on the mechanisms by which cuproptosis-related genes (CRGs) regulate ALIRI. Therefore, we explored the potential biomarkers related to cuproptosis to provide new insights into the treatment of ALIRI.Materials and methods: Datasets containing pre- and post-LTx lung biopsy samples and CRGs were obtained from the GEO database and previous studies. We identified differentially expressed CRGs (DE-CRGs) and performed functional analyses. Biomarker genes were selected using three machine learning algorithms. The ROC curve and logistic regression model (LRM) of these biomarkers were constructed. CIBERSORT was used to calculate the number of infiltrating immune cells pre- and post-LTx, and the correlation between these biomarkers and immune cells was analyzed. A competing endogenous RNA network was constructed using these biomarkers. Finally, the biomarkers were verified in a validation set and a rat LTx model using qRT-PCR and Western blotting.Results: Fifteen DE-CRGs were identified. GO analysis revealed that DE-CRGs were significantly enriched in the mitochondrial acetyl-CoA biosynthetic process from pyruvate, protein lipoylation, the tricarboxylic acid (TCA) cycle, and copper-transporting ATPase activity. KEGG enrichment analysis showed that the DE-CRGs were mainly enriched in metabolic pathways, carbon metabolism, and the TCA cycle. NFE2L2, NLRP3, LIPT1, and MTF1 were identified as potential biomarker genes. The AUC of the ROC curve for each biomarker was greater than 0.8, and the LRM provided an excellent classifier with an AUC of 0.96. These biomarkers were validated in another dataset and a rat LTx model, which exhibited good performance. In the CIBERSORT analysis, differentially expressed immune cells were identified, and the biomarkers were associated with the immune cells.Conclusion:NFE2L2, NLRP3, LIPT1, and MTF1 may serve as predictors of cuproptosis and play an important role in the pathogenesis of cuproptosis in ALIRI.

IntroductionPathogen spectrum of Hand, foot and mouth disease (HFMD) has substantially changed in the past decade in China. Growing evidence has indicated that anti-COVID-19 nonpharmaceutical interventions (NPIs) can support control of various infectious diseases, including intestinal diseases.MethodsIn this study, HFMD cases were enrolled from sentinel hospitals of Nanchang, Jiangxi province, and enteroviruses were genotyped using specific real time RT-PCR. We systematically characterized the epidemiology of HFMD based on the continuous molecular surveillance and estimated the impact of COVID-19 intervention on HFMD incidence using seasonal autoregressive integrated moving average (ARIMA) models.ResultsA total of 10247 HFMD cases were included during 2010-2022, of which 6121 enterovirus (EV)-positive cases (59.7%) were identified by real-time RT-PCR. Over 80% cases were associated with EV-A71 and coxsackievirus A16 (CVA16) during 2010-2012, while the type distribution significantly changed as CVA6 emerged to be dominant, accounting for 22.6%-59.6% during 2013-2022. It was observed that the prevalence patterns of EV-A71 and CVA16 were similar and both of them peaked in the second quarter and then leveled off. However, CVA6 was generally prevalent around the fourth quarter, demonstrating a staggered prevalence during 2010-2019. During the COVID-19 epidemic, the seasonal HFMD epidemic peak was restrained, and the ARIMA analysis indicated that the COVID-19 intervention had mitigated EV transmission during the first COVID-19 outbreak in early 2020. In addition, bivariate Spearman’s cross-correlation coefficients were estimated for the major types CVA6, CVA16 and EV-A71. Our analyses indicated the possible existence of correlations among CVA6, CVA16 and EV-A71 prevalence in the epidemiological level.DiscussionTaken together, the type distribution of HFMD has substantially changed over the last decade and CVA6 and CVA16 are currently the most predominant types co-circulating in Nanchang. The anti-COVID-19 NPIs significantly reduced the incidence of EV infections.

The active ingredients for aqueous film-forming foam (AFFF) are supplied as a concentrate, and the water used to dilute AFFF concentrates generally come from water sources around the fire site including seawater and river water. However, the effects of salt in water on fire-extinguishing performance of AFFF remain unclear. In this paper, we investigated the relationship between the interfacial properties, foam stability, and fire-extinguishing performance of three homemade AFFFs (nonionic AFFFAPG, amphoteric AFFFCAB and anionic AFFFSDS) and four commercial AFFFs. The seawater, firefighting water from different regions of China and deionized water were used to dilute AFFF concentrates. The results showed that AFFFAPG and AFFFCAB had a better performance than AFFFSDS in resisting the negative effects of salts on interfacial properties and foaming ability. In the fire-extinguishing tests, we found that dilution of AFFF with water samples containing high concentrations of Ca2+ and Mg2+ would weaken the fire-extinguishing performance. The traditional indicators characterizing the properties of foam (surface tension, liquid drainage rate, and spreading coefficient) could not explain the trend of fire extinguishing performance. The stability of AFFF in the presence of oil could be used to explain the difference in fire-extinguishing time of AFFF.

Objectives To systematically assess the associations between various immune-mediated diseases (IMDs) and human papillomavirus (HPV)-associated diseases.Design Retrospective cohort study.Setting UK Biobank.Participants A total of 500 371 subjects aged 40–69 years were eligible for the analysis, after excluding those with prevalent HPV-associated diseases at baseline and those who had withdrawn their informed consent or lacked information on sex.Exposure Eighty IMDs (involving allergic/atopic diseases, autoimmune diseases, immunodeficiency diseases, etc) were identified in the UK Biobank.Primary and secondary outcome measures The main outcome was the incidence of HPV-associated diseases (including warts and malignancies of the cervix, oropharynx, anus, penis, vulva and vagina). Cox proportional hazards model was used to estimate HRs and 95% CIs with particular adjustment for sexual behaviours. We also conducted subgroup analyses based on benign and malignant status, and anatomical sites of HPV-associated diseases, respectively.Results During a median of 12.0 years of follow-up, 2244 cases out of 500 371 subjects developed HPV-associated diseases. Overall, participants with IMDs had a higher risk of HPV-associated diseases than their controls after adjustment for sexual behaviours and other potential confounders (female: HR=1.90, 95% CI=1.66 to 2.17, p

To model fuzzy numbers with the confidence degree and better account for information uncertainty, Zadeh came up with the notion of Z-numbers, which can effectively combine the objective information of things with subjective human interpretation of perceptive information, thereby improving the human comprehension of natural language. Although many numbers are in fact Z-numbers, their higher computational complexity often prevents their recognition as such. In order to reduce computational complexity, this paper reviews the development and research direction of Z-numbers and deduces the operational rules for symmetric triangular Z-numbers. We first transform them into classical fuzzy numbers. Using linear programming, the extension principle of Zadeh, the convolution formula, and fuzzy number algorithms, we determine the operational rules for the basic operations of symmetric triangular Z-numbers, which are number-multiplication, addition, subtraction, multiplication, power, and division. Our operational rules reduce the complexity of calculation, improve computational efficiency, and effectively reduce the information difference while being applicable to other complex operations. This paper innovatively combines Z-numbers with classical fuzzy numbers in Z-number operations, and as such represents a continuation and innovation of the research on the operational laws of Z-numbers.

In order to prepare biomass-derived carbon materials with high specific capacitance at a low activation temperature (≤700 °C), nanoporous carbon materials were prepared from zanthoxylum bungeanum peels and seeds via the pyrolysis and KOH-activation processes. The results show that the optimal activation temperatures are 700 °C and 600 °C for peels and seeds. Benefiting from the hierarchical pore structure (micropores, mesopores, and macropores), the abundant heteroatoms (N, S, and O) containing functional groups, and plentiful electrochemical active sites, the PAC-700 and SAC-600 derive the large capacities of ~211.0 and ~219.7 F g−1 at 1.0 A g−1 in 6 M KOH within the three-electrode configuration. Furthermore, the symmetrical supercapacitors display a high energy density of 22.9 and 22.4 Wh kg−1 at 7500 W kg−1 assembled with PAC-700 and SAC-600, along with exceptional capacitance retention of 99.1% and 93.4% over 10,000 cycles at 1.0 A g−1. More significantly, the contribution here will stimulate the extensive development of low-temperature activation processes and nanoporous carbon materials for electrochemical energy storage and beyond.

Abstract Introduction The relationship between BMI and early renal function recovery after kidney transplantation is important due to the rising global obesity rates. Methods A retrospective study on 320 patients who received allograft kidney transplantation at Guangxi Medical University Hospital explored the BMI-kidney function relationship using various statistical methods. Mendelian randomization（MR） was also employed to investigate causality. Results Based on the univariate analysis, multivariate linear regression models, and trend analysis, it was found that there were significant positive correlations between BMI and creatinine, urea, and cystatin C on the 7th day after kidney transplantation (P

This paper takes a tunnel through a landslide in Northwest China as an example, constructs a mechanical model of a tunnel–landslide orthogonal system, and explores the deformation mechanism of a tunnel–landslide system and the technology of early warnings of near-slips. Given the problem that it is difficult to accurately monitor the deformation and damage characteristics of the tunnel–landslide system using conventional methods, FLAC3D was used to analyze the deformation mechanism of the tunnel–landslide orthogonal system and numerical simulation of the NPR constant resistance large deformation anchors for the early warning of near-slips. Based on the strength reduction method, by reducing the mechanical parameters of the shear strength of the slip zone and simulating different degrees of landslides, we obtained the change rules of the displacement and the axial force of the NPR constant-resistance large deformation anchor cable in the tunnel–landslide orthogonal system, established the warning mode of the Newtonian force tunnel–landslide orthogonal system, and successfully issued a near-slip warning in actual engineering applications. The above research is of great significance to the stability monitoring and risk assessment of tunnel–landslide systems.

As the building sector acts as an important CO2 emissions source, it is essential to renovate the existing building stock for carbon neutrality in the EU. The study reveals the effects of several novel renovation technologies on building energy consumption and CO2 emissions through building simulations. An English semi-detached house and a Spanish terraced house were chosen as the simulated demo houses. Renovation technologies were divided into passive, ventilation, and generation packages and simulated by packages and final combinations. Insulating breath membrane and bio-aerogel thermal insulation are the most appropriate single technology for lowering CO2 emissions for the English and Spanish demo houses, respectively. For generation technologies, solar assisted heat pump is a more recommended CO2 emissions conservation technology than PVT system in both climate conditions. The demo houses’ CO2 emissions can be reduced maximally by over 70% after renovating with the final combination including solar assisted heat pump. The current economic feasibility of the novel technologies is limited by various issues, for example, manufacturing costs and energy prices. Nevertheless, considering most of the issues can be solved with time, they will be economically feasible renovation measures in the future.

Energy stress activates AMPK leading to metabolic plasticity and therapy resistance in cancer. Here, the authors show that AMPK activation decreases Prospero-related homeobox 1 (PROX1) levels impairing branched amino acid metabolism and tumourigenesis in liver and lung cancer models.

The hot deformation behavior of Mg-9.16Gd-3.03Y-1.44Zn-0.61Zr alloy was examined by hot compression experiments at 623–753 K with strain rates 0.1–20 s−1. Flow stress-strain curves developed an Arrhenius-type equation with adjustment for strain. The influence of strain on microstructure evolution was studied by optical microscope. The results showed that with the increase of deformation, LPSO phase broken and kinked and interacted with dislocations to promote nucleation of dynamic recrystallization (DRX) grains. In addition, the effects of temperature and strain rate on DRX during hot compression were examined using electron back-scatter diffraction. The results demonstrated that the volume fraction of DRX grains improved as temperature and strain rate increased. The alloys could adapt to plastic deformation caused mostly by continuous and discontinuous dynamic recrystallization. Transmission electron microscopy was then utilized to observe the phase structure. The dynamic precipitates occurred after hot compression, and the LPSO phase was broken and kinked, which coordinated the plastic deformation. Using the Avrami equation, the DRX dynamic model of the alloy at 0.1 s−1 was established for the first time.

This paper addresses the numerical and experimental performance analysis of a windows heat recovery system made of heat pipes. For modelling, the heat pipe is considered as a pseudo solid material with high value of effective thermal conductivity. An experimental investigation using a window heat recovery prototype was carried out to predict the value of effective thermal conductivity of the heat pipes and to validate the numerical model. After validation, a parametric analysis was conducted to investigate the performance of the recovery system for different working conditions (mass flow rate and temperature difference between exhausted and supplied air). Based on the performance obtained in the parametric analysis, energy performance in building and the impact on velocity and pressure distributions are also evaluated with the support of CFD analysis. It is found that the effectiveness of window heat recovery made of heat pipes depends on ventilation rate and temperature difference between exhausted and supplied air. Increasing ventilation rates and temperature differences decrease the effectiveness. For ventilation rate between 10–60 m 3/h and temperature difference 10–30 °C, effectiveness between 65%–95% and pressure drop 4–80 Pa are obtained. For performance in building, the power consumption can be reduced between 3%–24% and the thermal comfort increased.

[Objective] The developing history of soil erosion research in China was reviewed, the major research achievements were summarized, and the current problems and key research fields in the future were analyzed to provide a reference for China's soil and water conservation, regional ecological construction, and high-quality green development. [Methods] Based on years of work experiences from field investigations and academic research on soil erosion, long-term consideration has been given to major issues related to soil erosion in China through numerous academic discussions and communications with leading experts. [Results] A series of major research achievements have been obtained in the field of soil erosion in China during the last one hundred years, but there have also some drawbacks and problems. In the future, soil erosion research in China should focus on several key fields, such as the improvement, promotion, and accuracy evaluation of soil erosion prediction models; calculation methods and model construction for slope runoff; evaluation of the representativeness and validity of results from simulated rainfall and flume scouring experiments; and so on. More attention should be given to the mechanisms of soil erosion processes, model applications, technical methods, response evaluations, bottleneck problems, and other issues. [Conclusion] Researches over the past century has shown that soil erosion research should be conducted based on national conditions. Symbolic achievements could only be achieved by determining and adjusting research directions according to the characteristics of soil erosion, the research status, and the changes in social demands in China. Meanwhile, in the new era when the country is vigorously promoting the construction of ecological civilization, soil erosion research must be refreshed with new ideas and emphases. Moreover, soil and water conservation practices should also be integrated with rural revitalization and ecological construction by giving priority to soil erosion prevention and reducing disturbance to soil. Besides, we should change the previously used model of instituting laws and regulations after soil destruction and water loss occurred.

Acute lung injury (ALI) is a pneumonic response characterized by neutrophil infiltration. Macrophage efferocytosis is the process whereby macrophages remove apoptotic cells, and is required for ALI inflammation to subside. The glycoprotein ulinastatin (UTI) has an anti‐inflammatory effect during the acute stages of ALI, but its effect on efferocytosis and the subinflammatory stage of ALI is unclear. Extracellular signal‐regulated kinase 5 (ERK5) is a key protein in efferocytosis, and we thus hypothesized that it may be activated by UTI to regulate efferocytosis and the resolution of pneumonia. To test this hypothesis, here we monitored phagocytosis of macrophages through in vivo and in vitro experiments. Pulmonary edema, neutrophil infiltration, protein exudation, and inflammatory factor regression were observed on days 1, 3, 5, and 7 in vivo. RAW264.7 cells were pretreated with different concentrations of UTI and ERK5 inhibitors, and the expression of tyrosine‐protein kinase Mer (Mer) protein on macrophage membrane was detected. UTI increased the phagocytosis of apoptotic neutrophils by macrophages in vitro and in vivo, and promoted the resolution of pneumonia. The protein expression of ERK5 and Mer increased with UTI concentration, while the expression of Mer was down‐regulated by ERK5 inhibitors. Therefore, our results suggest that UTI enhances efferocytosis and reduces lung inflammation and injury through the ERK5/Mer signaling pathway, which may be one of the targets of UTI in the treatment of lung injury.

Abstract Psychological capital (PsyCap) motivates citizens to actively participate in social affairs. This study aims to promote the application of the PsyCap theory in the field of public affairs and help promote the establishment of a food safety social co-governance system in practice. Based on a questionnaire survey of 752 urban citizens in Wuxi, China, this study used latent profile analysis (LPA) to classify citizens into three different latent groups from the perspective of PsyCap and its four-dimensional composition. The influence of PsyCap and its various dimensions on the willingness of citizens in different groups to participate in food safety social co-governance was assessed and compared using usefulness analysis. Results showed that citizens showed obvious differences in their PsyCap, which can be divided into low, medium, and high levels. All dimensions of PsyCap had an impact on willingness to participate, but the impact differed among groups. The overall PsyCap level had a greater impact on citizens’ willingness to participate than any single dimension. In the future construction of a food safety social co-governance system, different guidance and intervention strategies should be implemented based on the differences in PsyCap among different groups.

Background There are rare studies assessing the efficacy of inhaled glucocorticoids (ICS) , the common therapy for chronic obstructive pulmonary disease (COPD) . MicroRNAs (miRNAs) have been confirmed to be involved in the development of COPD, among which miR-210 and miR-181a are closely related to COPD. Moreover, there is lack of clinical research on changes of miR-210 and miR-181a in COPD patients treated with ICS. Objective To examine the changes and response predictive values of serum miR-210 and miR-181a levels in stable COPD patients treated with ICS. Methods Eighty-six COPD outpatients were recruited from 363 Hospital from January 2017 to June 2020. All of them received four-week budesonide and formoterol inhalation. Treatment efficacy was assessed by the results of spirometry test or COPD Assessment Test (CAT) 〔responsive to treatment was defined as the COPD stage was reduced at least one stage or CAT score was reduced at least 2 points after treatment〕. Pre- and post-treatment lung function parameters〔including forced expiratory volume in one second (FEV1) , forced vital capacity (FVC) , and peak expiratory flow (PEF) 〕 and serum miR-210 and miR-181a levels were collected. Pearson correlation analysis was used to assess the associations of serum miR-210 and miR-181a levels with FEV1, FVC, and PEF as well as CAT score before and after the treatment. ROC analysis was used to assess the predictive values of serum miR-210 and miR-181a levels for treatment response in stable COPD. Results Compared with pre-treatment, stable COPD patients demonstrated significantly increased values of FEV1, FVC, and PEF, and significantly decreased CAT score, serum miR-210 and miR-181a levels after treatment (P

Abstract Development towards HVDC grids is drawing intense development of HVDC circuit‐breakers (CBs). The increasing rated voltage and capacity requires HVDC CBs with excellent performance to be installed and comprehensive tests on HVDC CBs are indispensable. This paper contributes to clarifying clearer test requirements on the current interruption test, which is the most challenging one and proposing a novel applicable test method. It is the toughest test because when an HVDC CB interrupts fault current, a high transient interruption voltage (TIV) is produced by the operation of metal oxide surge arrester (MOSA), and a large current continues flowing through MOSA simultaneously, which means considerable energy is demanded for the test. To verify an HVDC CB's current interruption ability, voltage withstand ability and energy dissipation ability in single test can be costly and even impractical in extra high voltage classes. Alternatively, a multi‐part test method is reasonable and valuable, in which the HVDC CB can be tested with large current and high voltage one after another, while the energy dissipation ability will be verified separately. At last, a proposed synthetic test circuit is validated by a simulation and a low voltage experiment, creating high equivalence between the simulation and the validation test.

ObjectiveTo reveal the effects of specific factors on aflatoxin B1 （AFB1） contamination in peanut oil and the status of AFB1 contamination in peanut oil in Guangdong Province from 2017 to 2018 was taken as an example.MethodsA total of 637 peanut oil samples were collected from 21 cities in Guangdong Province from 2017 to 2018， and their labels were recorded. The content of AFB1 in peanut oil was detected according to “GB 5009.22—2016 Determination of aflatoxin group B and group G in foods”. The temperature data of manufacturing place was obtained from ECMWF Reanalysis v5 database （ERA5） and the average temperature of the month before production was calculated， and the correlation between temperature and AFB1 content was then analyzed.ResultsThe total detection rate of AFB1 in peanut oil samples was 65.3% with 24.6% over-standard rate. There was no over-standard sample in the standardized packages， while the bulk samples had a higher over-standard level rate and the median content of AFB1 was significantly higher than that in the standardized package samples. Among several meteorological factors， average temperature of the month before peanut oil production had a strong relevance to the over-standard rate and content of AFB1 in the samples. The median content of AFB1 in bulk peanut oil samples with average temperature of pre-production above 25 ℃ was about 3.5 times that of the samples with average temperature below 22 ℃. However， other meteorological factors showed no correlation with AFB1 content in peanut oil.ConclusionAFB1 in bulk peanut oil samples in Guangdong Province from 2017 to 2018 has a high over-standard rate， and the average temperature of pre-production is a key factor affecting the content of AFB1. Therefore， the government should raise the awareness of the production environment and production process to ensure the quality of bulk peanut oil and reduce the risk of AFB1 exposure and other risks.

Black hole (BH) ultracompact X-ray binaries (UCXBs) are potential Galactic low-frequency gravitational wave (GW) sources. As an alternative channel, BH UCXBs can evolve from BH+He star binaries. In this work, we perform a detailed stellar evolution model for the formation and evolution of BH UCXBs evolving from the He star channel to diagnose their detectability as low-frequency GW sources. Our calculations found that some nascent BH+He star binaries after the common-envelope (CE) phase could evolve into UCXB-LISA sources with a maximum GW frequency of ∼5 mHz, which can be detected in a distance of 10 kpc (or 100 kpc). Once BH+He star systems become UCXBs through mass transfer, they would emit X-ray luminosities of ∼10 ^38 erg s ^−1 , making them ideal multimessenger objects. If the initial He-star masses are ≥0.7 M _⊙ , those systems are likely to experience two Roche lobe overflows, and the X-ray luminosity can reach a maximum of 3.5 × 10 ^39 erg s ^−1 in the second mass-transfer stage. The initial He-star masses and initial orbital periods of progenitors of Galactic BH UCXB-LISA sources are in the range of 0.32–2.9 M _⊙ and 0.02–0.19 days, respectively. Nearly all BH+He star binaries in the above parameter space can evolve into GW sources whose chirp masses can be accurately measured. Employing a population synthesis simulation, we predict the birthrate and detection number of Galactic BH UCXB-LISA sources evolving from the He star channel are R = 2.2 × 10 ^−6 yr ^−1 and 33 for an optimistic CE parameter, respectively.

The sea surface roughness parameterization and the universal stability function are key components of the evaporation duct prediction model based on the Monin–Obukhov similarity theory. They determine the model’s performance, which in turn affects the efficiency and accuracy of electromagnetic applications at sea. In this study, we collected layered meteorological and hydrological observation data and preprocessed them to obtain near-surface reference modified refractivity profiles. We then optimized the sea surface roughness parameterization and the universal stability function using particle swarm optimization and simulated annealing algorithms. The results show that the particle swarm optimization algorithm outperforms the simulated annealing algorithm. Compared to the original model, the particle swarm optimization algorithm improved the prediction accuracy of the model by 5.09% under stable conditions and by 9.97% under unstable conditions, demonstrating the feasibility of the proposed method for optimizing the evaporation duct prediction model. Subsequently, we compared the electromagnetic wave propagation path losses under two different evaporation duct heights and modified refractivity profile states, confirming that the modified refractivity profile is more suitable as the accuracy criterion for the evaporation duct prediction model.

Objectives: To investigate the differences in functional brain activity and connectivity between nurses working long-term shifts and fixed day shift and explore their correlations with work-related psychological conditions. Methods: Thirty-five nurses working long-term shifts and 35 nurses working fixed day shifts were recruited. After assessing work-related psychological conditions, such as burnout and perceived stress of these two groups of nurses, amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) analyses were performed to investigate the between-group differences in brain functional activity and connectivity. Furthermore, correlation analysis between the ALFF/FC metrics and psychological conditions was conducted. Results: Compared with nurses working fixed day shifts, nurses working long-term shifts showed higher levels of burnout, perceived stress, and depression scores; lower z-transformed ALFF (zALFF) values in the right dorsolateral prefrontal cortex (dlPFC), right superior parietal lobule (SPL), and right anterior cingulate cortex (ACC); and higher zALFF values in the right middle temporal gyrus (voxel-level p < 0.001, cluster-level p < 0.05, gaussian random field (GRF) correction), as well as lower FC values in the right dlPFC-right SPL and right dlPFC-right ACC (p < 0.05, false discovery rate (FDR) corrected). Moreover, the FC values in the right dlPFC-right SPL were negatively correlated with the perceived stress score in nurses working long-term shifts (p < 0.05, FDR corrected). Conclusions: This study demonstrated that nurses working long-term shifts had lower functional activity and weaker functional connectivity in the right frontoparietal network, which mainly includes the right dlPFC and right SPL, than those working on regular day shift. The current findings provide new insights into the impacts of long-term shift work on nurses’ mental health from a functional neuroimaging perspective.

The gas sensitivity of the W defect in WS2 (VW/WS2) to five toxic gases—HCHO, CH4, CH3HO, CH3OH, and CH3CH3—has been examined in this article. These five gases were adsorbed on the VW/WS2 surface, and the band, density of state (DOS), charge density difference (CDD), work function (W), current–voltage (I–V) characteristic, and sensitivity of adsorption systems were determined. Interestingly, for HCHO-VW/WS2, the energy level contribution of HCHO is closer to the Fermi level, the charge transfer (B) is the largest (0.104 e), the increase in W is more obvious than other adsorption systems, the slope of the I–V characteristic changes more obviously, and the calculated sensitivity is the highest. To sum up, VW/WS2 is more sensitive to HCHO. In conclusion, VW/WS2 has a great deal of promise for producing HCHO chemical sensors due to its high sensitivity and selectivity for HCHO, which can aid in the precise and efficient detection of toxic gases.

Both the anomalous magnetic braking of Ap/Bp stars and the surrounding circumbinary disk models can account for the formation of black hole (BH) low-mass X-ray binaries (LMXBs), while the simulated effective temperatures of the donor stars are significantly higher than the observed values. Therefore, the formation of BH LMXBs is still not completely understood. In this work, we diagnose whether the dynamical friction between dark matter and the companion stars can drive BH binaries to evolve toward the observed BH LMXBs and alleviate the effective temperature problem. Assuming that there exists a density spike of dark matter around BH, the dynamical friction can produce an efficient angular momentum loss, driving BH binaries with an intermediate-mass companion star to evolve into BH LMXBs for a spike index higher than γ = 1.58. Our detailed stellar evolution models show that the calculated effective temperatures can match the observed value of most BH LMXBs for a spike index range of γ = 1.7–2.1. However, the simulated mass-transfer rates when γ = 2.0 and 2.1 are too high to be consistent with the observed properties showing that BH LMXBs appear as soft X-ray transients. Therefore, the dynamical friction of dark matter can only alleviate the effective temperature problem of those BH LMXBs with a relatively short orbital period.

Most of magnesium matrix composites processed by traditional technique have poor anti-corrosion and biological performance, because of uneven microstructure, especially for nonuniform distribution of reinforced particles. Friction stir processing (FSP) can be used for preparing magnesium matrix composites with refine grains and uniform distribution of reinforced particles. In this paper, multi-pass FSP is employed to fabricate the ZrO2 particles reinforced AZ31 magnesium composites. The results showed that the microstructure of the composites become more homogeneous with the increase of FSP pass. The grain size is refined from 10 μm of basal metal (BM) to 8.2 μm of two-pass FSP (FSP-2P) and 4.5 μm of four-pass FSP (FSP-4P), respectively. The ultimate tensile strength, yield strength and elongation of BM is 283 MPa, 137 MPa and 15.5%. The mechanical properties are improved with the increase of FSP pass. The ultimate tensile strength, yield strength and elongation of FSP-4P is 328 MPa, 160 MPa, and 11.5%, respectively. Moreover, the corrosion resistance is arranged in the following order: FSP-2P

We investigate a novel model of coupled stochastic differential equations modeling the interaction of mussel and algae in a random environment, in which combined effect of white noises and telegraph noises formulated under regime switching are incorporated. We derive sufficient condition of extinction for mussel species. Then with the help of stochastic Lyapunov functions, a well-grounded understanding of the existence of ergodic stationary distribution is obtained. Meticulous numerical examples are also employed to visualize our theoretical results in detail. Our analytical results indicate that dynamic behaviors of the stochastic mussel-algae model are intimately associated with two kinds of random perturbations.

The intercropping of grass in orchards has beneficial effects on soil properties and soil microbial communities and is an important soil management measure for improving orchard productivity and land-use efficiency. However, few studies have explored the effects of grass intercropping on rhizosphere microorganisms in walnut orchards. In this study, we explored the microbial communities of clear tillage (CT), walnut/ryegrass (Lolium perenne L.) (Lp), and walnut/hairy vetch (Vicia villosa Roth.) (Vv) intercropping system using MiSeq sequencing and metagenomic sequencing. The results revealed that the composition and structure of the soil bacterial community changed significantly with walnut/Vv intercropping compared to CT and walnut/Lp intercropping. Moreover, the walnut/hairy vetch intercropping system had the most complex connections between bacterial taxa. In addition, we found that the soil microorganisms of walnut/Vv intercropping had a higher potential for nitrogen cycling and carbohydrate metabolism, which may be related to the functions of Burkholderia, Rhodopseudomonas, Pseudomonas, Agrobacterium, Paraburkholderia, and Flavobacterium. Overall, this study provided a theoretical basis for understanding the microbial communities associated with grass intercropping in walnut orchards, providing better guidance for the management of walnut orchards.

The popularization of the Internet and the convenience of e-commerce are driving the online restaurant industry’s rapid development of worldwide. However, serious information asymmetries in online food delivery (OFD) transactions not only aggravate food safety risks, resulting in simultaneous government and market failures, but also intensify consumers’ perceived risks. This paper innovatively constructs a research framework for the governance participation willingness of OFD platform restaurants and consumers under the moderating effects of perceived risks from the perspective of control theory and then develops scales for analyzing the governance willingness of both restaurants and consumers. Using data collected through a survey, this paper explores the effect of control elements on governance participation by restaurants and consumers and analyzes the moderating effects of perceived food safety risks. Results showed that both government regulations and restaurant reputation (formal control elements) and online complaints and restaurant management response (informal control elements) can increase governance participation willingness among both platform restaurants and consumers. The moderating effects of perceived risks are partially significant. When the risks perceived by restaurants and consumers are strong, government regulation and online complaints can more effectively boost the governance participation willingness of restaurants and consumers, respectively. At this moment, consumers’ willingness to pursue problem solving through online complaints is evidently enhanced. Accordingly, the perceived risks and the online complaints jointly motivate restaurants and consumers to participate in governance activities.

Abstract A new concentrated ternary salt ether‐based electrolyte enables stable cycling of lithium metal battery (LMB) cells with high‐mass‐loading (13.8 mg cm−2, 2.5 mAh cm−2) NMC622 (LiNi0.6Co0.2Mn0.2O2) cathodes and 50 μm Li anodes. Termed “CETHER‐3,” this electrolyte is based on LiTFSI, LiDFOB, and LiBF4 with 5 vol% fluorinated ethylene carbonate in 1,2‐dimethoxyethane. Commercial carbonate and state‐of‐the‐art binary salt ether electrolytes were also tested as baselines. With CETHER‐3, the electrochemical performance of the full‐cell battery is among the most favorably reported in terms of high‐voltage cycling stability. For example, LiNixMnyCo1–x–yO2 (NMC)‐Li metal cells retain 80% capacity at 430 cycles with a 4.4 V cut‐off and 83% capacity at 100 cycles with a 4.5 V cut‐off (charge at C/5, discharge at C/2). According to simulation by density functional theory and molecular dynamics, this favorable performance is an outcome of enhanced coordination between Li+ and the solvent/salt molecules. Combining advanced microscopy (high‐resolution transmission electron microscopy, scanning electron microscopy) and surface science (X‐ray photoelectron spectroscopy, time‐of‐fight secondary ion mass spectroscopy, Fourier‐transform infrared spectroscopy, Raman spectroscopy), it is demonstrated that a thinner and more stable cathode electrolyte interphase (CEI) and solid electrolyte interphase (SEI) are formed. The CEI is rich in lithium sulfide (Li2SO3), while the SEI is rich in Li3N and LiF. During cycling, the CEI/SEI suppresses both the deleterious transformation of the cathode R‐3m layered near‐surface structure into disordered rock salt and the growth of lithium metal dendrites.

Large strain gradient is crucial for flexoelectricity. Here, the authors reveal the generality and tunability of large strain gradients at grain boundaries in oxides, explaining the possible effects on the electrical activities of ceramics.

The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated exhausted CD8+ T cells (Tex) in HNSCC. We performed cell-level multi-omics sequencing on human HNSCC samples to decipher the multi-dimensional characteristics of Tex cells. A proliferative exhausted CD8+ T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified. Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. P-Tex cells could aggregate in the antigen-presenting cell niches and activate certain signaling pathways. Together, our findings suggest a promising role for P-Tex cells in the prognosis of patients with HPV-positive HNSCC by providing modest but persistent anti-tumor effects.

IntroductionThe trend of sound speed profile (SSP) inversion is towards wide-area sound speed estimation. However, the traditional inversion method of dividing the latitude and longitude grids has limitations in terms of significantly lower accuracy when samples are lacking. k-means clustering algorithm (K-means) can divide the training class to achieve high accuracy estimation.MethodThis paper proposes a grid-free pre-classification inversion scheme based on empirical orthogonal function (EOF) vectors. The scheme is based on the K-means to classify the samples according to the perturbation mode of the SSP. After classification, the SSP inversion is carried out using the self-organizing map algorithm (SOM). The experimental sea area is selected from the South China Sea, and the inversion results are evaluated using root mean square error (RMSE) as the criterion.ResultThe inversion results show that the inversion error is 2.1 m/s for the pre-classification solution and 2.7 m/s for the solution without pre-classification, a steady improvement of more than 20% in the inversion error. Accuracy is also improved by 2.14 m/s in the depth range where the sound speed perturbance is greatest.DiscussionThis pre-classification scheme has smaller inversion errors and the classification results are reasonable in terms of distribution in time and space. It provides a feasible solution for SSP inversion in sea areas where samples are lacking.

Introduction: Parameter mismatch poses a challenge to source localization in cases involving environments with seabed uncertainties. By including environmental parameters in the search space, focalization can be used to estimate the location of the source using environmental information that is limited a priori. Methods: To reduce the number of parameters, a simplified seabed model is proposed here for such focalization. Only two geoacoustic parameters—the amplitude F and phase cF of reflection—are used to describe the seabed. Focalization is generally tested using genetic algorithms for the colored noise case (COLNOISE) benchmark problem. Results: The proposed simplified model can obtain the location of the source more easily than a layered model. Due to its advantage in terms of parameter sensitivity and inter-coupling, the simplified model can ensure the robustness of the results of inversion. The proposed method was tested on a broadband signal in the Asian Seas International Acoustics Experiment (ASIAEX2001), where both the location and the geoacoustic parameters were easily inverted. Discussion: The simplified model provides a sufficiently high acoustic resolution for focalization, and its reduction of the geoacoustic parameters helpes solve the problem of inversion.

Laser-scribed graphene oxide (GO) shows great promise for high-performance, cost-effective humidity sensors. However, when using the commonly employed Gaussian beam, the Rayleigh length is relatively short, leading to potential stability issues during large-area processing, especially when defocusing occurs. In this paper, we utilize a diffraction-free Bessel beam to one-step fabricate reduced graphene oxide (rGO) electrodes specifically designed for humidity sensing applications. The effects of defocusing and laser power on the line width and resistance of the fabricated electrodes are investigated, giving the optimal processing parameters for Bessel laser writing of GO. The line width, resistance, and sheet resistance of the rGO electrode are stable at a defocusing distance within ±1.00 mm. Defocusing also proves to be effective in reducing the ablation region during the fabrication process. The temperature and humidity responses of the electrodes are examined, focusing on those fabricated with typical defocusing settings, and the related mechanisms are discussed. Proof-of-principle rGO/GO/rGO humidity sensors are demonstrated, and were one-step fabricated using a Bessel beam with both focusing and defocusing settings. The corresponding humidity response results evidence that rGO humidity sensors can be fabricated using a Bessel beam, even in the defocusing cases. The investigation into the Bessel-beam-based laser fabrication technique offers promising prospects for rapid, flexible, and cost-effective production of graphene-based humidity sensors. Meanwhile, the study of defocusing may enhance the fabrication stability to withstand defocusing conditions effectively.

Organic scintillators, materials with the ability to exhibit luminescence when exposed to X-rays, have aroused increasing interest in recent years. However, the enhancement of radioluminescence and improving X-ray absorption of organic scintillators lie in the inherent dilemma, due to the waste of triplet excitons and weak X-ray absorption during scintillation. Here, we employ halogenated thermally activated delayed fluorescence materials to improve the triplet exciton utilization and X-ray absorption simultaneously, generating efficient scintillation with a low detection limit, which is one order of magnitude lower than the dosage for X-ray medical diagnostics. Through experimental study and theoretical calculation, we reveal the positive role of X-ray absorption, quantum yields of prompt fluorescence, and intersystem crossing in promoting the radioluminescence intensity. This finding offers an opportunity to design diverse types of organic scintillators and expands the applications of thermally activated delayed fluorescence.

IntroductionIn underwater acoustic applications, the three-dimensional sound speed distribution has a significant impact on signal propagation. However, the traditional sound speed profile (SSP) measurement method requires a lot of manpower and time, and it is difficult to popularize. Satellite remote sensing can collect information on a large ocean surface area, from which the underwater information can be derived.MethodIn this paper, we propose a method for reconstructing the SSP based on an extensible end-to-end tree boosting (XGBoost) model. Combined with satellite remote sensing data and Argo profile data, it extracts the characteristic matrix of the SSP and analyzes the contribution rate of each order matrix to reduce the introduction of noise. The model inverts the SSP above 1000 m in the South China Sea by using the root mean square error (RMSE) as the precision evaluation index.ResultThe results showed that the XGBoost model could better reconstruct the SSP above 1000 m, with a RMSE of 1.75 m/s. Compared with the single empirical orthogonal function regression (sEOF-r) model of the linear regression method, the RMSE of the XGBoost model was reduced by 0.59 m/s.DiscussionFor this model, the RMSE of the inversion results was smaller, the robustness was better, and the regression performance was superior to that of the sEOF-r model at different depths. This study provided an efficient tree boosting model for SSP reconstruction, which could reliably and instantaneously monitor the 3D sound speed distribution.

The frequent occurrences of cyberbullying on social platforms have sparked a great deal of social conflict, and bystander intervention plays a crucial role in preventing the escalation of cyberbullying. This research examines the impact of victim self-disclosure on bystander intervention in cyberbullying through two experimental studies. The studies collected data from March to July of 2022, utilizing a convenience sampling approach to recruit university students as experiment participants. Study 1 recruited 247 valid participants, while Study 2 recruited 522 eligible participants. The results of Study 1 indicate that the perceptible dimensions (frequency, privacy, and valence) of victim self-disclosure impact bystander intervention. Specifically, in a low privacy context, positive self-disclosure increases bystander intervention, while negative self-disclosure does the opposite. The results of Study 2 suggest that the valence of self-disclosure affects bystander intervention through the mediation of victim blaming, with interpersonal distance moderating the impact of victim self-disclosure valence on the extent of victim blaming. This moderated mediation model clarifies the psychological process by which the valence of victim self-disclosure affects bystander intervention. The findings of this study contribute to the understanding of the social psychological process behind bystander intervention, providing a scientific basis and pathway for reducing cyberbullying and fostering a harmonious online environment.

Abstract Background A universally acknowledged cancer staging system considering all aspects of the T‐, N‐, and M‐classifications for middle ear squamous cell carcinoma (MESCC) remains absent, limiting the clinical management of MESCC patients. Materials and Methods A total of 214 MESCC patients were extracted from the SEER (the Surveillance, Epidemiology, and End Results) database between 1973 and 2016. The relationships between patient’s characteristics and prognoses were analyzed by Kaplan–Meier and Cox proportional hazards regression models. Novel staging schemes for MESCC were designed by adjusted hazard ratio (AHR) modeling method according to the combinations of Stell’s T‐classification and the eighth AJCC N‐ and M‐classifications, of which performances were evaluated based on five criteria: hazard consistency, hazard discrimination, explained variation, likelihood difference, and balance. Results T‐classification was the most significant prognostic factor for MESCC patients in multivariable analysis (p = 0.021). The N‐ and M‐classifications also had obvious prognostic effect but were not statistically significant by multivariate analysis due to the limited metastasis events. Three novel staging schemes (AHR‐Ⅰ–Ⅲ models, different combination of T‐ and N‐classifications) and ST (solely derived from Stell’s T‐classification) were developed, among which the AHR‐Ⅰ staging scheme performed best. Conclusions Tumor extension, quantified by Stell’s T‐classification, is the most significant prognostic factor for MESCC patients. However, our AHR‐Ⅰ staging scheme, a comprehensive staging scheme that integrating T‐, N‐, and M‐classifications, might be an optimal option for clinical practitioners to predict MESCC patients’ prognosis and make proper clinical decisions.

In this paper, we develop two stochastic mussel-algae models: one is autonomous and the other is periodic. For the autonomous model, we provide sufficient conditions for the extinction, nonpersistent in the mean and weak persistence, and demonstrate that the model possesses a unique ergodic stationary distribution by constructing some suitable Lyapunov functions. For the periodic model, we testify that it has a periodic solution. The theoretical findings are also applied to practice to dissect the effects of environmental perturbations on the growth of mussel.