523 results on '"Kean, Leslie S"'
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102. End the pain: Start with antiracism
103. Spatiotemporal single-cell profiling of gastrointestinal GVHD reveals invasive and resident memory T cell states
104. Divergent roles of retinoic acid signaling in T regulatory cell function
105. Potent interaction between CMV reactivation and GVHD: Immunologic evidence for the blunting of CMV-driven immune reconstitution in the setting of GVHD in transplant patients
106. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
107. 336 - Abatacept for the Prevention of Graft Versus Host Disease in Pediatric Patients Receiving 7/8 HLA-Mismatched Unrelated Transplant for Hematologic Malignancies: A Real-World Analysis
108. 335 - Single-Cell RNA-Seq Reveals an Interferon-Driven Inflammatory CD4 Naïve T Cell Subpopulation at Day 100 in Hematopoietic Stem Cell Transplant Patients That Ultimately Develop Chronic Gvhd
109. 334 - Early Breakthrough T Cell Proliferation Despite CNI/MTX Prophylaxis Is a Harbinger of Acute Gvhd (AGVHD) and Is Controlled By Abatacept: Mechanism of Success of the ABA2 Agvhd Prevention Trial
110. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
111. The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future
112. Human OX40L–CAR-Tregstarget activated antigen-presenting cells and control T cell alloreactivity
113. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease
114. 405 - Prospective Cohort Study of Immune Suppression Taper and Discontinuation
115. 404 - Improved Overall Survival of Patients Treated with Abatacept in Combination with a Calcineurin Inhibitor and Methotrexate Following Allogeneic Hematopoietic Stem Cell Transplantation: Analysis of the Center for International Blood and Marrow Transplant Research Database
116. 383 - Abatacept for the Prevention of Gvhd in Pediatric Patients Receiving 7/8 HLA-Mismatched Unrelated Transplant for Hematologic Malignancies: A Single Center Experience
117. IL2 enhances ex-vivo expanded regulatory T cell persistence after adoptive transfer
118. T Cell Costimulation Blockade with CTLA4-Ig (Abatacept) for Acute Gvhd Prevention in HLA Matched and Mismatched Unrelated Donor Transplantation: Results of the First Phase 2 Trial
119. Comparison of mechanisms of anemia in mice with sickle cell disease and β-thalassemia: Peripheral destruction, ineffective erythropoiesis, and phospholipid scramblase-mediated phosphatidylserine exposure
120. A cure for murine sickle cell disease through stable mixed chimerism and tolerance induction after nonmyeloablative conditioning and major histocompatibility complex–mismatched bone marrow transplantation
121. 326 - Immune Reconstitution Following Unrelated Donor Hematopoietic Cell Transplantation for Pediatric Non-Malignant Diseases Using Abatacept Graft-Versus-Host Disease Prophylaxis
122. 33 - Comparable Outcomes for Matched and Mismatched Unrelated Donor (URD) Transplantation with the Addition of Abatacept to Standard Graft Versus Host Disease Prophylaxis
123. 10 - Predicting Immune Pathology after Hematopoietic Stem Cell Transplant (HCT) with Day 100 Transcriptomics: Naïve CD4 T Cell Expansion Versus Regulatory Programming Predicts Patients Who Develop De Novo Chronic Gvhd (CGVHD) Versus Those Displaying Operational Immune Tolerance
124. Chimeric Antigen Receptor T Cell–Mediated Neurotoxicity in Nonhuman Primates
125. Delineating tissue-specific alloimmunity during acute GVHD
126. Combined OX40L and mTOR blockade controls effector T cell activation while preserving T reg reconstitution after transplant
127. A Novel Therapeutic Strategy to Control Conventional T-Cells While Supporting Treg Reconstitution Post-Transplant: Long-Term GVHD-Free Survival by Combining OX40L Blockade with Rapamycin
128. Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses
129. Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates
130. Risk factors for transplant-associated thrombotic microangiopathy and mortality in a pediatric cohort
131. IL-2 enhances ex vivo–expanded regulatory T-cell persistence after adoptive transfer
132. CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis
133. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.
134. Preclinical Testing of Antihuman CD28 Fab′ Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease
135. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality
136. Biological role of T Memory Stem Cells as a Cellular Reservoir for Graft-versus-Host Disease
137. End the pain: Start with antiracism.
138. Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice
139. B-cell–directed CAR T-cell therapy activates CD8+cytotoxic CARnegbystander T cells in patients and nonhuman primates
140. The Adverse Event Landscape of Stem Cell Transplant: Evidence for AGVHD Driving Early Transplant Associated Toxicities
141. Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention
142. Immunophenotypic parameters and RBC alloimmunization in children with sickle cell disease on chronic transfusion
143. A phase I study of sirolimus in combination with metronomic therapy in children with recurrent and refractory solid/CNS tumors.
144. 3 - A Novel Therapeutic Strategy to Control Conventional T-Cells While Supporting Treg Reconstitution Post-Transplant: Long-Term GVHD-Free Survival by Combining OX40L Blockade with Rapamycin
145. Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.
146. Defining the Primate T Cell Transcriptome during GvHD: New Data Implicating Sonic Hedgehog and Aurora Kinase Pathways in GvHD Pathogenesis and Prevention
147. Exhaustive TCR Deep Sequencing Reveals That CMV Reactivation Fundamentally Resets Immune Reconstitution after Transplant and Results in Significant Deficits in the Effector Memory TCR Repertoire
148. Acute Myeloid Leukemia
149. T-Cell Transcriptome Analysis Reveals the Mechanisms Controlling Synergy Between Costimulation Blockade and mTOR Inhibition during Graft Versus Host Disease Prevention
150. Preventing Primate GvHD Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Activation and Preservation of the Naïve Cell Phenotype Predicts GvHD-Free Survival
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