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Amaç: Vitamin B12 tüm vitaminleriçindeki en karmaşık kimyasal yapıya sahip olanı olup, hematolojik ve sinirselsistemin normal fonksiyon görebilmesi için gereklidir. Dolayısıyla, vitamin B12 eksikliği tedaviedilmediğinde depresyon gibi psikiyatrik belirtilere yol açabilir. Bu çalışmadaamacımız, majör depresyon tanılı hastalarda vitamin B12 eksikliği sıklığınıtespit etmekti.Metod: Çalışmada Kayseri Eğitim ve Araştırma Hastanesi’nde DSM-5 kriterleri bazalınarak majör depresyon tanısı konan 425 erişkin hastaya ait verilerdeğerlendirildi. Tüm hastaların CBC, serum vitamin B12 ve folat düzeyleri ilerutin biyokimyasal tetkikleri incelendi. Bulgular: Toplam 425 depresif hastanınverileri incelendi. Hastaların%74.6’sı kadındı. Vitamin B12 eksikliği 93 hastada tespit edildi (% 21.9).Kadınlarda vitamin B12 eksikliği % 22.7 iken, erkeklerde bu oran % 19.4 olaraksaptandı. Her iki cinsiyet grubunda da folik asit, Hb, PLT ve WBC sayılarındaanlamlı farklılık yoktu.Sonuç: : Bu çalışmanın sonuçları, majördepresyon hastalarında vitamin B12 eksikliğinin nadir olmadığını göstermiştir.Depresif semptomları olan hastalarda fizikbulgularıdeğerlendirmek ve vitamin B12 eksikliğini saptamaya yönelik gerekli testleriyapmak faydalı olabilir. Aim: Vitamin B12 has the most complex chemical structure of all vitamins and it is necessary for normal functioning of hematological and nervoussystem. Thus, vitamin B12 deficiency could cause psychiatric symptoms such asdepression when it is untreated. Our aim was to determine vitamin B12deficiency frequency of patients diagnosed with major depression.Method: The present study included 425adult patients with major depression based on Diagnostic and Statistical Manualof Mental Disorders, fifth edition (DSM-5) criteria at Kayseri Education and Research Hospital.In all patients, laboratory evaluations were performed: complete blood count(CBC), serum vitamin B12 andfolate levels, and routine biochemical tests.Results: Theresults of 425 depressive patients were analyzed. Depression was prevelant among females (74.6%). Also, total 93patients (21.9%) were vitamin B12 deficient. While in female patients vitaminB12 deficiency was 22.7%, in male patients, the rate was 19.4%. There wereno significant differences between folate and hemoglobin(Hb) levels, platelet (PLT) and white blood cell (WBC) counts.Conclusion: The results of this study shownthat, the frequency of vitamin B12 deficiency among people is major depressionnot uncommon. It would be beneficial to consider the physical symptoms and toconduct the required examinations to determine vitamin B12 deficiency among this patients.

Aim: Polycythemia is a disease state in which the proportion of blood volumethat is occupied by red blood cells increases. Flow-mediatedvasodilation (FMD) is a non-invasive ultrasound method of evaluatingendothelial function. Theaim of this prospective study was to compare the systemic endothelial functionsby FMD method in patients with polycythemia withcontrol group.Method: Thepresent study included 50 patients with polycytemia (hemoglobin (Hb) ≥16.5 g/dl) and 61 healthy control group aged ≥ 18 years at KayseriEducation and Research Hospital were included. In allindividuals, the following laboratory evaluations were performed: completeblood count (CBC), serum iron indices, and routine biochemical tests. Also, all participants underwent the FMDstudy at Cardiology department with Doppler ultrasound. Results: The results of 111 participantswere analyzed. On the other hand, the rate ofsmoking was 76% in the polycythemia group, while it was 36.1% in the controlgroup (p< 0.005). Likewise, Hb, hematocrit andserum lipid parameters were significantly increased in polycythemia groupexcept high density lipoprotein (HDL) cholesterol (p < 0.001). Also, FMD was significantlyreduced in polycythemiagroup compared with control group (7.78 ± 4.83% vs. 10.98 ± 7.86%,respectively) (p= 0.010).Conclusion: Theresults of the study indicate that polycythemia is associated with endothelialdysfunction and hyperlipidemia. As the noninvasive ultrasound method forperipheral endothelial testing is generally accurate and reproducible, and canbe performed serially, FMD can be used safely in patients with polycythemia toevaluation of endothelial functions.Amaç: Polisitemi, kan volümünün bir parçasını teşkil eden eritrositmiktarındaki artışla karakaterize bir patolojik durumdur. Akış aracılı genişletme (FMD) yöntemi, sistemikvasküler fonksiyonların değerlendirilmesinde giderek önemi artan birnon-invaziv tetkik olup, çeşitli hastalıklarda bu yöntem ile vasküler endotelhakkında önemli bilgiler edinilmiştir. Bu prospektif çalışmada amacımız,polisitemik bireylerde FMD yöntemi ile vasküler fonksiyonları değerlendirmek vesağlıklı kontrol grubu ile karşılaştırmaktı. Metod: Bu çalışmaya; Kayseri Eğitim veAraştırma Hastanesi’ne başvuran 18 yaş ve üzeri, 61 sağlıklı ve Hb değerinormal sınırlarda olan gönüllü ile, 50 polisitemi olgusu alındı. Polisitemitanısı için Hb > 16.5 g/dL baz alındı. Bireylerin tam kan sayımları, demir parametreleri ve rutin biyokimyasaltetkikleri istendi. Katılımcılara Kardiyoloji kliniğinde Doppler ultrasonografieşliğinde FMD işlemi uygulandı.Bulgular: Toplam 111 olgunundeğerlendirildiği çalışmada, gruplar arasında yaş, cinsiyet, vücut kitleindeksi, hipertansiyon ve diabet oranları bakımından fark yoktu. Buna karşın,sigara içim oranı polisitemi grubunda kontrol grubuna göre anlamlı şekildeyüksekti (%76 ve %36.1, sırasıyla) (p< 0.005). Hb, hematokrit ve serum lipidparametreleri de yüksek densiteli lipoprotein (HDL) kolesterol dışındapolisitemi grubunda anlamlı şekilde yüksekti (p < 0.001). Ayrıca, FMD oranıpolisitemik grupta kontrol grubuna göre anlamlı şekilde düşük bulundu (% 7.78 ±4.83 ve %10.98 ± 7.86, sırasıyla)(p= 0.010). Sonuçlar: Bulgularımızla, polisitemik bireylerde vaskülerendotelyal fonksiyonların olumsuz etkilendiği ve hiperlipidemi birlikteliğiortaya konmuştur. Non invaziv ve kolay uygulanabilen FMD yöntemi ile,polisiteminin muhtemel endotelyal disfonksiyon gelişimindeki rolüöngörülebilir.

5th International Eurasian Hematology Congress -- OCT 15-19, 2014 -- Antalya, TURKEY, WOS: 000347244200054, …

Blood component donations by apheresis have become more common in modern blood transfusion practices. We compared three apheresis instruments (Fenwal Amicus, Fresenius COM.TEC, and Trima Accel) with regard to platelet (PLT) yield, collection efficiency (CE), and collection rate (CR). The single-needle or double-needle plateletpheresis procedures of the three instruments were compared in a retrospective, randomized study in 270 donors. The blood volume processed was higher in the COM.TEC compared with the Amicus and Trima. Also there was a significantly higher median volume of ACD used in collections on the COM.TEC compared with the Amicus and Trima. The PLT yield was significantly lower with the COM.TEC compared with the Amicus and Trima. Additionally, the CE was significantly lower with the COM.TEC compared with the Amicus and Trima. There was no significant difference in median separation time and CR between the three groups. When procedures were compared regarding CE by using Amicus device, it was significantly higher in single-needle than double-needle plateletpheresis. When double-needle Amicus system was compared with double-needle COM.TEC system, CE and PLT yield were significantly higher with Amicus system. When single-needle Amicus system was compared with single-needle Trima system, CE and PLT yield were significantly higher with Trima system. All instruments collected PLTs efficiently. However, the CE was lower with the COM.TEC compared with the Amicus and Trima. Also, we found Amicus single-needle system collected PLTs more efficiently compared with the double-needle system. CE and PLT yields were significantly higher with the single-needle Trima instrument compared with the single-needle Amicus device. J. Clin. Apheresis 30:171-175, 2015. (c) 2014 Wiley Periodicals, Inc.

Introduction: During the last three decades, major advances have been made in the therapy of Hodgkin's lymphoma. However, despite these advances, Hodgkin's lymphoma has a poor prognosis in the elderly. The proportion of Hodgkin's lymphoma patients aged > 60 ranges in the different reports between 15% and 35%. This study aimed to examine clinical characteristics, treatment outcomes and prognostic factors affecting patient survival in Hodgkin's lymphoma patients aged 65 years or older. Material methods: Hodgkin's lymphoma patients at 65 years of age and older managed within last 5 years in a total of 5 centers in Turkey were retrospectively assessed. Results: The median age of a total of 32 patients was 71 (65-83) years. Elderly patients presented more frequently with B symptoms, elevated sedimentation rate, mixed cellularity histologic subtype and comorbid disease. Less frequent were bulky disease, bone marrow involvement, and the application of autologous stem cell transplantation. The nodular lymphocyte predominant subtype and lymphocyte rich subtype were not observed at all. Eastern Cooperative Oncology Group, ferritin, total protein, and histological type were significant predictors affecting survival (p