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2,677 results on '"Kim, Hae Won"'

101. Contributors

Author

Aggarwal, Aakriti, primary, Anil Kumar, P.R., additional, Buzgo, Matej, additional, Byrne, Ellen, additional, Carr, Andrew J., additional, Chui, Chih-Yao, additional, Craig, Duncan Q.M., additional, Cui, Zhanfeng, additional, Damodaran, Vinod, additional, Davoodi, Pooya, additional, Dubey, Poornima, additional, Franco, Rose Ann G., additional, Garg, Deepa, additional, Gill, Elisabeth L., additional, Gopinath, P., additional, Kasoju, Naresh, additional, Kim, Hae Won, additional, Komeri, Remya, additional, Kumar, Alok, additional, Lach, Antonina A., additional, Martins, Joana A., additional, Matai, Ishita, additional, Menon, Deepthy, additional, Misra, Manju, additional, Mohamed Ameer, Jimna, additional, Morris, Hayley L., additional, Mouthuy, Pierre–Alexis, additional, Nair, Shantikumar V., additional, Nguyen, Chikim, additional, Nguyen, Linh, additional, Padalhin, Andrew R., additional, Pai, Roopesh, additional, Parker, Geoff J.M., additional, Patel, Kapil D., additional, Ramakrishna, Seeram, additional, Reshmi, C.R., additional, Sah, Mahesh Kumar, additional, Shery Huang, Yan Yan, additional, Simaite, Aiva, additional, Takiar, Vinita, additional, Thakkar, Shreya, additional, Verisqa, Fiona, additional, Wang, Wenyu, additional, Wei, Gang, additional, Williams, Gareth R., additional, Yang, Fang, additional, Ye, Hua, additional, Yu, Deng-Guang, additional, and Zhou, Fenglei, additional

Published
2021
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103. Sol–Gel Synthesis and Electrospraying of Biodegradable (P2O5)55–(CaO)30–(Na2O)15 Glass Nanospheres as a Transient Contrast Agent for Ultrasound Stem Cell Imaging

Author

Foroutan, Farzad, Jokerst, Jesse V, Gambhir, Sanjiv S, Vermesh, Ophir, Kim, Hae-Won, and Knowles, Jonathan C

Subjects
Biomedical Imaging, Bioengineering, Generic health relevance, Calcium Compounds, Cell Survival, Chemistry Techniques, Synthetic, Contrast Media, Electricity, Glass, Mesenchymal Stem Cells, Nanospheres, Nanotechnology, Oxides, Phosphorus Compounds, Sodium Compounds, Temperature, Ultrasonography, sol-gel, electrospraying, phosphate-based glasses, ultrasound imaging, sol−gel, Nanoscience & Nanotechnology
Abstract

Ultrasound imaging is a powerful tool in medicine because of the millisecond temporal resolution and submillimeter spatial resolution of acoustic imaging. However, the current generation of acoustic contrast agents is primarily limited to vascular targets due to their large size. Nanosize particles have the potential to be used as a contrast agent for ultrasound molecular imaging. Silica-based nanoparticles have shown promise here; however, their slow degradation rate may limit their applications as a contrast agent. Phosphate-based glasses are an attractive alternative with controllable degradation rate and easily metabolized degradation components in the body. In this study, biodegradable P2O5-CaO-Na2O phosphate-based glass nanospheres (PGNs) were synthesized and characterized as contrast agents for ultrasound imaging. The structure of the PGNs was characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), (31)P magic angle spinning nuclear magnetic resonance ((31)P MAS NMR), and Fourier transform infrared (FTIR) spectroscopy. The SEM images indicated a spherical shape with a diameter size range of 200-500 nm. The XRD, (31)P NMR, and FTIR results revealed the amorphous and glassy nature of PGNs that consisted of mainly Q(1) and Q(2) phosphate units. We used this contrast to label mesenchymal stem cells and determined in vitro and in vivo detection limits of 5 and 9 μg/mL, respectively. Cell counts down to 4000 could be measured with ultrasound imaging with no cytoxicity at doses needed for imaging. Importantly, ion-release studies confirmed these PGNs biodegrade into aqueous media with degradation products that can be easily metabolized in the body.

Published
2015

111. Microbiome analysis of circulating bacterial extracellular vesicles in obsessive‐compulsive disorder.

Author

Kang, Jee In, Seo, Jun Ho, Park, Chun Il, Kim, Shin Tae, Kim, Yoon‐Keun, Jang, Jung‐Kyu, Kwon, Cheol‐O, Jeon, Sumoa, Kim, Hae Won, and Kim, Se Joo

Subjects
OBSESSIVE-compulsive disorder, EXTRACELLULAR vesicles, RIBOSOMAL DNA, BACTERIAL DNA, HYPERVARIABLE regions
Abstract

Aim: The present study examined the microbiome abundance and composition of drug‐naive or drug‐free patients with obsessive‐compulsive disorder (OCD) compared with healthy controls. In addition, in the OCD group, the microbiome composition was compared between early‐onset and late‐onset OCD. Methods: Serum samples were collected from 89 patients with OCD and 107 age‐ and sex‐matched healthy controls. Bacterial DNA was isolated from bacteria‐derived extracellular vesicles in serum and then amplified and quantified using primers specific to the V3‐V4 hypervariable region of the 16S ribosomal RNA gene. The 16S ribosomal DNA gene amplicon sequencing was performed. Results: The pooled estimate showed that α‐diversity was significantly reduced in patients with OCD compared with that in healthy controls (PShannon = 0.00015). In addition, a statistically significant difference was observed in β‐diversity between patients with OCD and healthy controls at the order (P = 0.012), family (P = 0.003), genus (P < 0.001), and species (P = 0.005) levels. In the microbiome composition, Pseudomonas, Caulobacteraceae (f), Streptococcus, Novosphingobium, and Enhydrobacter at the genus level were significantly less prevalent in patients with OCD than in controls. In addition, among patients with OCD, the microbial composition in the early‐onset versus late‐onset types was significantly different with respect to the genera Corynebacterium and Pelomonas. Conclusion: The present study showed an aberrant microbiome in patients with OCD, suggesting a role of the microbiota‐brain interaction in the pathophysiology of OCD. Further longitudinal studies with larger sample sizes adjusting for various confounders are warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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141. Fluoroscopic criteria for on-site evaluation of failed intussusception reduction during air enema technique

Author

Kim, Hae Won, Jeon, Tae Yeon, Kim, Kyunga, Yoo, So-Young, Choe, Yon Ho, Lee, Sanghoon, Seo, Jeong-Meen, Kim, Ji Hye, and Moon, Sung-Hoon

Subjects
Original Article, Radiology, Nuclear Medicine and imaging
Abstract

BACKGROUND: There is no reliable fluoroscopic criteria for failed intussusception reduction during air enema technique. METHODS: This retrospective case-control study included 373 episodes of ileocolic intussusceptions who had undergone air enema under fluoroscopy. All procedures were initially classified by conventional fluoroscopic criteria: presumptive successful procedures (PSP) vs. presumptive failed procedures (PFP). PFP were divided into true failure, false failure, and undetermined groups. The configuration and size of the residual mass were evaluated on fluoroscopic images. Statistical analyses included Mann-Whitney U-test, Fisher’s exact test, receiver operating characteristic (ROC) analysis, logistic regression analyses, and Kruskal-Wallis rank sum test with a post hoc Tukey test. RESULTS: PSP was 264 episodes (71%) and PFP was 109 episodes (29%). The true failure was 40 (37%) and false failure was 48 (44%). The true failure group commonly showed a larger size and round configuration for the residual mass than false failure (P

Published
2022

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