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Recently, the 3rd Generation Partnership Project has developed vehicle-to-everything communication to manage and advance future traffic safety and mobility. In this study, we propose a position-based resource allocation scheme for vehicle-to-vehicle communication. The proposed scheme allocates a different frequency and time resources based on vehicle speed, density, direction, and position. Our performance analysis is based on urban and freeway cases involving periodic message transmission. Simulation results show that the proposed scheme can improve the cumulative distribution function of packet reception ratio (PRR) and average PRR. [ABSTRACT FROM AUTHOR]

Mode-matching analysis of a coaxially fed annular slot surrounded by corrugations is conducted in this study. An electromagnetic boundary value problem of a coaxially fed annular slot surrounded with corrugations is rigorously solved based on the Hankel transform, eigenfunction expansion, and mode-matching method. The radiated field is represented in a fast-convergent series that is amenable to numerical analysis. Numerical results are presented to illustrate the radiation behaviors in terms of the geometries of the corrugations and compared with measurement data. [ABSTRACT FROM AUTHOR]

Enhanced transmission through a circular aperture surrounded by concentric surface corrugations in a conducting plane is investigated. A boundary-value problem of electromagnetic wave scattering from a circular aperture surrounded by concentric surface corrugations is rigorously solved based on the Hankel transform, eigenfunction expansion, and mode-matching method. The transmission coefficient is represented in a fast-convergent series that is amenable to numerical analysis. Computation is performed to illustrate the transmission behaviors in terms of the geometries of the concentric corrugations. The effects of the higher-order modes on the transmission coefficients are also discussed. [ABSTRACT FROM AUTHOR]

Directional emission from a slit surrounded by rectangular grooves on the exit surface in a conducting plane is investigated. An electromagnetic boundary-value problem dealing with a slit surrounded by rectangular grooves on the exit surface in a conducting plane is rigourously solved based on the Fourier transform, eigenfunction expansion, and mode-matching method. The radiation pattern from the slit is represented in a series and computed to illustrate the radiation behaviors in terms of the groove geometry. [ABSTRACT FROM PUBLISHER]

Memristors have diverse potential for improving data storage through linear memory control and synaptic operation in AI and neuromorphic computing. Prior research on optimizing memristors in next‐generation devices has generally indicated that emerging arrays and vertical structures can improve memory density, although special fabrication steps are required to realize improved operation. Until now, many obstructions, such as the sneak path current and forming processes from the initial device in array structure operation at the device level, have limited the development of array‐based memristor devices for further progressing circuits and integrated design. In this paper, memristor array studies are examined that have suggested solutions for sneak path current and forming operation problems at the device level. Ultimately, representative solutions are proposed to progress memristors into array structures by introducing the latest research on one diode‐one RRAM (1D1R), one selector‐one RRAM (1S1R), overshoot suppressed RRAM (OSRRAM), self‐rectifying cell (SRC), charge trap memory (CTM) and their applications. Additionally, essential details demonstrating the practical implementation of these devices in crossbar array memory are investigated. Finally, the advantages and perspectives of these array‐based memristor solutions are summarized. [ABSTRACT FROM AUTHOR]

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. FGFR4 has been implicated in HCC progression, making it a promising therapeutic target. We introduce an approach for identifying novel FGFR4 inhibitors by sequentially adding fragments to a common warhead unit. This strategy resulted in the discovery of a potent inhibitor, 4c , with an IC 50 of 33 nM and high selectivity among members of the FGFR family. Although further optimisation is required, our approach demonstrated the potential for discovering potent FGFR4 inhibitors for HCC treatment, and provides a useful method for obtaining hit compounds from small fragments.

The hafnium oxide-based ferroelectric tunnel junction (FTJ) has been actively researched because of desirable advantages such as low power and CMOS compatibility to operate as a memristor. In the case of HfAlO x (HAO), the remanent polarization ( P r ) value is high and the atomic radius of Al is smaller than that of Hf; therefore, ferroelectricity can be better induced without mechanical force. In this paper, we propose an FTJ using HAO as a ferroelectric layer through electrical analysis and experiments; further, we experimentally demonstrate its capability as a synaptic device. Moreover, we evaluate the maximum 2 P r and TER value of the device according to the difference in conditions of thickness and cell area. The optimized device conditions are analyzed, and a large value of 2 P r (>∼43 μC cm -2 ) is obtained. Furthermore, we show that paired-pulse facilitation, paired-pulse depression, and spike-timing-dependent plasticity can be utilized in HAO-based FTJs. In addition, this study demonstrates the use of an FTJ device as a physical reservoir to implement reservoir computing. Through a series of processes, the synaptic properties of FTJs are verified for the feasibility of their implementation as an artificial synaptic device.

The ferroelectric characteristics of a metal-ferroelectric-metal (MFM) ferroelectric tunneling junction (FTJ) capacitor device are investigated herein. The device consists of an aluminum-doped hafnium oxide (HAO) insulator sandwiched between tungsten (W) and titanium nitride (TiN) metal electrodes. Rapid thermal annealing (RTA) is performed for 20 s under a nitrogen atmosphere at temperatures of 750 °C, 800 °C, and 850 °C to find that ferroelectricity with a large remanent polarization ( P r ) of 41.28 μC cm -2 can be obtained at the optimum annealing temperature of 800 °C. The presence of ferroelectricity is confirmed by polarization-switching positive-up-negative-down (PUND) measurements and by the hysteric polarization-voltage ( P - V ) loop. All devices exhibit excellent reliability, with an endurance of up to ∼10 6 cycles and long retention characteristics. In addition, the interfacial paraelectric capacitance ( C i ) values of the three HAO FTJs are investigated via pulse-switching measurements. The results indicate that the HAO film annealed at 800 °C for 20 s exhibits an excellent tunneling electro-resistance (TER) ratio of 186% and this is attributed to the extra paraelectric layer formed between the ferroelectric layer and the bottom electrode. The detailed findings of this study are expected to assist in the development of hafnium oxide-based ferroelectric non-volatile memory applications.

The gene amplification of human epidermal growth factor receptor 2 (HER2) plays an essential role in the proliferation and progression of several cancers. However, HER2 inhibitors such as lapatinib strongly suppress wild-type EGFR, resulting in severe adverse effects. Therefore, there is an unmet need for highly selective HER2 inhibitors. In this study, we describe the design and synthesis of novel quinazoline derivatives that exhibit enhanced selectivity for HER2 over wild-type EGFR. Structure-activity relationship analysis indicated that the selectivity for HER2 over EGFR depends on the aniline moiety at C-4 and the substituents at C-6 in the quinazoline derivatives. Compound 7c with an IC 50 of 8 nM for HER2 exhibited significantly higher selectivity for HER2 over EGFR, with a 240-fold improvement over lapatinib. In addition, the synthesized compounds exhibited anti-proliferative activity in the nanomolar range against SKBR3, a human breast cancer cell line that overexpresses HER2., (© 2022. The Pharmaceutical Society of Korea.)

Mass deconvolution, the determination of proteoform precursor and fragment masses, is crucial for top-down proteomics data analysis. Here we describe the detailed procedure to run FLASHDeconv, an ultrafast, high-quality mass deconvolution tool. Both spectrum- and feature-level deconvolution results are obtainable in various output formats by FLASHDeconv. FLASHDeconv is runnable in different environments such as the command line and OpenMS workflows., (© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Tumor-associated macrophages (TAMs) are predominantly associated with tumor growth. Colony-stimulating factor 1 receptor (CSF1R) acts as a key regulator of TAM survival and differentiation and is a molecular target for cancer therapies. Herein, novel CSF1R inhibitors were identified through a replacement strategy for the hinge-binding moiety. The introduction of imidazo[1,2-a]pyridine (49) or pyrazolo[1,5-a]pyridine (50) as hinge binders led to 87% and 82% inhibition at 10 nM for CSF1R in the enzymatic assay, with IC 50 values of 25 nM and 27 nM in MNFS60 cells, respectively. These derivatives significantly inhibited CSF1R phosphorylation in cells. Our approach could be utilized as a strategy to discover novel kinase inhibitors., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)