106 results on '"Kramer, Michal"'
Search Results
102. Uveitis Induced by Biological Agents Used in Cancer Therapy.
- Author
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Deitch-Harel I MD, Raskin E MD, Habot-Wilner Z MD, Friling R MD, Amer R MD, and Kramer M MD
- Subjects
- Acrylamides adverse effects, Adolescent, Adult, Aged, 80 and over, Aniline Compounds adverse effects, Female, Glucocorticoids therapeutic use, Humans, Ipilimumab adverse effects, Male, Middle Aged, Nivolumab adverse effects, Retrospective Studies, Uveitis, Anterior diagnosis, Uveitis, Anterior drug therapy, Vemurafenib adverse effects, Antineoplastic Agents adverse effects, Drug-Related Side Effects and Adverse Reactions etiology, Immune Checkpoint Inhibitors adverse effects, Neoplasms drug therapy, Uveitis, Anterior chemically induced
- Abstract
Purpose : To report cases of uveitis induced by biological therapy given for cancer. Methods : Retrospective review of medical charts of patients. Results : Included were six patients aged 14-81 years. Three were treated with vemurafenib and one each with nivolumab, ipilimumab, and osimertinib. The oncological diagnoses were metastatic thyroid carcinoma, pleomorphic xanthoastrocytoma, metastatic melanoma, adenocarcinoma of the lung, and metastatic breast cancer. Ocular manifestations appeared 4-82 weeks after the biological treatment was initiated. The most common ocular presentation was anterior uveitis. Onset was sudden in all cases. The median duration of uveitis was 70 weeks. Treatment included topical or systemic corticosteroids; one patient received a single intravitreal steroid injection in one eye. Conclusions : Uveitis may rarely be induced by treatment with biological agents for cancer. Both oncologists and ophthalmologists should be aware of this potential side effect. Early detection and management can prevent permanent complications and save the patient's vision.
- Published
- 2021
- Full Text
- View/download PDF
103. Endogenous fungal endophthalmitis: risk factors, clinical course, and visual outcome in 13 patients.
- Author
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Corredores J, Hemo I, Jaouni T, Habot-Wilner Z, Kramer M, Shulman S, Jabaly-Habib H, Al-Talbishi A, Halpert M, Averbukh E, Levy J, Deitch-Harel I, and Amer R
- Abstract
Aim: To analyze the risk factors, ophthalmological features, treatment modalities and their effect on the visual outcome in patients with endogenous fungal endophthalmitis (EFE)., Methods: Data retrieved from the medical files included age at presentation to the uveitis clinic, gender, ocular symptoms and their duration before presentation, history of fever, eye affected, anatomical diagnosis and laboratory evidence of fungal infection. Medical therapy recorded included systemic antifungal therapy and its duration, use of intravitreal antifungal agents and use of oral/intravitreal steroids. Surgical procedures and the data of ophthalmologic examination at presentation and at last follow-up were also collected., Results: Included were 13 patients (20 eyes, mean age 58y). Ten patients presented after gastrointestinal or urological interventions and two presented after organ transplantation. In one patient, there was no history of previous intervention. Diagnostic vitrectomy was performed in 16 eyes (80%) and vitreous cultures were positive in 10 of the vitrectomized eyes (62.5%). In only 4 patients (31%), blood cultures were positive. All patients received systemic antifungal therapy. Sixteen eyes (80%) received intravitreal antifungal agent with voriconazole being the most commonly used. Visual acuity (VA) improved from 0.9±0.9 at initial exam to 0.5±0.8 logMAR at last follow-up ( P =0.03). A trend of greater visual improvement was noted in favor of eyes treated with oral steroids (±intravitreal dexamethasone) than eyes that were not treated with steroids. The most common complication was maculopathy. Twelve eyes (60%) showed no ocular complications., Conclusion: High index of suspicion in patients with inciting risk factors is essential because of the low yield of blood cultures and the good general condition of patients at presentation. Visual prognosis is improved with the prompt institution of systemic and intravitreal pharmacotherapy and the immediate surgical intervention. Oral±local steroids could be considered in cases of prolonged or marked inflammatory responses in order to hasten control of inflammation and limit ocular complications., (International Journal of Ophthalmology Press.)
- Published
- 2021
- Full Text
- View/download PDF
104. Proinflammatory cytokines in a mouse model of central retinal artery occlusion.
- Author
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Kramer M, Dadon S, Hasanreisoglu M, Monselise Y, Avraham BR, Feldman A, Eldar I, Weinberger D, and Goldenberg-Cohen N
- Subjects
- Animals, Chemokine CXCL2 analysis, Chemokine CXCL2 blood, Chemokine CXCL2 genetics, Cytokines blood, Cytokines genetics, Disease Models, Animal, Gene Expression Profiling, Interleukin-6 analysis, Interleukin-6 blood, Interleukin-6 genetics, Mice, Mice, Inbred C57BL, Polymerase Chain Reaction, RNA, Messenger analysis, RNA, Messenger blood, RNA, Messenger genetics, Retinal Artery Occlusion chemically induced, Retinal Artery Occlusion veterinary, Rose Bengal, Statistics, Nonparametric, Time Factors, Tumor Necrosis Factor-alpha analysis, Tumor Necrosis Factor-alpha blood, Tumor Necrosis Factor-alpha genetics, Cytokines analysis, Retina chemistry, Retinal Artery Occlusion metabolism
- Abstract
Purpose: To analyze cytokines in the retina and serum in an experimental model of central retinal artery occlusion (CRAO) in mice., Methods: CRAO was induced by laser activation of intravenously injected rose bengal, a photosensitive dye, in 60 C57Bl/6 mice. mRNA and protein levels of macrophage inhibitory protein-2 (MIP-2), interleukin-6 (IL-6), and tumor necrosis factor- alpha (TNF-alpha) were analyzed using real-time polymerase chain reaction, and western blot, respectively. Cytokine levels in serum were measured by ELISA. Analysis was performed at various time intervals from CRAO induction., Results: In the retina, MIP-2 and IL-6 mRNA expression decreased 3 h after induction of CRAO and increased thereafter, peaking at 12-24 h. By 7 days, levels were again mostly undetectable. TNF-alpha mRNA expression increased at 3 h and decreased to control levels at 7 days. At the protein level, all cytokines were present at 3 h, following similar patterns to their respective gene expression thereafter. In serum, MIP-2 and TNF-alpha levels peaked early, and decreased to control levels at 12 h, with a second late rise of TNF-alpha. IL-6 levels increased between 3 and 12 h and decreased at 24 h., Conclusions: Temporal variations in cytokines were observed following the induction of CRAO, both at the retinal mRNA expression and protein levels. These temporal changes, and the variable effects of the cytokines at the different time intervals, should be taken into account during the formulation of therapeutic strategies.
- Published
- 2009
105. Increased plasma and optic nerve levels of IL-6, TNF-alpha, and MIP-2 following induction of ischemic optic neuropathy in mice.
- Author
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Avraham BC, Dotan G, Hasanreisoglu M, Kramer M, Monselise Y, Cohen Y, Weinberger D, and Goldenberg-Cohen N
- Subjects
- Animals, Chemokine CXCL2 blood, Enzyme-Linked Immunosorbent Assay, Interleukin-6 blood, Male, Mice, Mice, Inbred C57BL, Optic Neuropathy, Ischemic blood, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Tumor Necrosis Factor-alpha blood, Chemokine CXCL2 metabolism, Interleukin-6 metabolism, Optic Nerve metabolism, Optic Neuropathy, Ischemic metabolism, Tumor Necrosis Factor-alpha metabolism
- Abstract
Purpose: To investigate levels of proinflammatory cytokines in a mouse model of anterior ischemic optic neuropathy (rAION)., Methods: AION was induced in C57/BL6 mice and levels of IL-6, TNF-alpha, and MIP-2 were measured in plasma by ELISA and in the optic nerves by RT-PCR at predetermined intervals., Results: Plasma: IL-6 levels were elevated immediately after rAION induction and decreased gradually thereafter. TNF-alpha showed an early peak on day 1 and again from day 21. MIP-2 levels were increased until day 7. Optic nerve: IL-6, TNF-alpha, and MIP-2 levels increased within a few hours and then decreased gradually. IL-6 had a second peak on day 3., Conclusions: Proinflammatory cytokines may play a role in the pathogenesis of rAION.
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- 2008
- Full Text
- View/download PDF
106. [Ocular manifestation of bronchogenic carcinoma: simultaneous occurrence of diffuse uveal melanocytic proliferation and uveal metastases].
- Author
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Bahar I, Weinherger D, Kremer MR, Starobin D, and Kramer M
- Subjects
- Cell Differentiation, Cell Division, Fluorescein Angiography, Humans, Male, Middle Aged, Ultrasonography, Uveal Neoplasms diagnosis, Uveal Neoplasms diagnostic imaging, Uveal Neoplasms pathology, Carcinoma, Bronchogenic pathology, Lung Neoplasms pathology, Uvea pathology, Uveal Neoplasms secondary
- Abstract
Systemic cancer may affect the eye and orbit as metastatic disease or paraneoplastic retinal degeneration. This is a case report of a 55-year-old man with unilateral visual loss as the presenting symptom of metastatic adenocarcinoma of lung in one eye and diffuse uveal melanocytic proliferation in the other. Fundoscopy, B-scan ultrasonography, fluorescein angiography and the workup for inflammatory, infectious and neoplastic diagnoses are presented. In heavy smokers, bronchogenic carcinoma should be highly suspected.
- Published
- 2007
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