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101. Clinical, Endoscopic and Histological Outcomes in Induction of Moderate-to-Severe Ulcerative Colitis: A Systematic Review with Meta-Analysis

Author

Magro, Fernando, primary, Estevinho, Maria Manuela, additional, Dias, Cláudia Camila, additional, Correia, Luís, additional, Lago, Paula, additional, Ministro, Paula, additional, Portela, Francisco, additional, Feakins, Roger, additional, Danese, Silvio, additional, and Peyrin-Biroulet, Laurent, additional

Published
2020
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104. Rehospitalization_SupplementaryFigures – Supplemental material for Rehospitalization rates, costs, and risk factors for inflammatory bowel disease: a 16-year nationwide study

Author

Santiago, Mafalda, Magro, Fernando, Correia, Luís, Portela, Francisco, Ministro, Paula, Lago, Paula, Trindade, Eunice, and Dias, Cláudia Camila

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Rehospitalization_SupplementaryFigures for Rehospitalization rates, costs, and risk factors for inflammatory bowel disease: a 16-year nationwide study by Mafalda Santiago, Fernando Magro, Luís Correia, Francisco Portela, Paula Ministro, Paula Lago, Eunice Trindade and Cláudia Camila Dias in Therapeutic Advances in Gastroenterology

Published
2020
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105. sj-pdf-1-tag-10.1177_1756284820965790 – Supplemental material for Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays

Author

Rocha, Cátia, Lago, Paula, Fernandes, Samuel, Correia, Luís, Portela, Francisco, Vieira, Ana Isabel, Patita, Marta, Arroja, Bruno, Ministro, Paula, Alves, Catarina, Dias, Cláudia Camila, and Magro, Fernando

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-tag-10.1177_1756284820965790 for Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays by Cátia Rocha, Paula Lago, Samuel Fernandes, Luís Correia, Francisco Portela, Ana Isabel Vieira, Marta Patita, Bruno Arroja, Paula Ministro, Catarina Alves, Cláudia Camila Dias and Fernando Magro in Therapeutic Advances in Gastroenterology

Published
2020
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106. sj-pdf-2-tag-10.1177_1756284820965790 – Supplemental material for Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays

Author

Rocha, Cátia, Lago, Paula, Fernandes, Samuel, Correia, Luís, Portela, Francisco, Vieira, Ana Isabel, Patita, Marta, Arroja, Bruno, Ministro, Paula, Alves, Catarina, Dias, Cláudia Camila, and Magro, Fernando

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-pdf-2-tag-10.1177_1756284820965790 for Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays by Cátia Rocha, Paula Lago, Samuel Fernandes, Luís Correia, Francisco Portela, Ana Isabel Vieira, Marta Patita, Bruno Arroja, Paula Ministro, Catarina Alves, Cláudia Camila Dias and Fernando Magro in Therapeutic Advances in Gastroenterology

Published
2020
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107. Cutaneous Crohnʼs disease

Author

Teixeira, Marta, Machado, Susana, Lago, Paula, Sanches, Madalena, and Selores, Manuela

Published
2006

108. Characterizing Word Embeddings for Zero-Shot Sensor-Based Human Activity Recognition

Author

Department of Applied Science for Integrated System Engineering Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Department of Basic Sciences Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Department of Human Intelligence Systems Kyushu Institute of Technology, Hibikino 808-0196, Japan, Matsuki, Moe, Lago, Paula, Inoue, Sozo, Department of Applied Science for Integrated System Engineering Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Department of Basic Sciences Kyushu Institute of Technology, Kitakyushu 804-8550, Japan, Department of Human Intelligence Systems Kyushu Institute of Technology, Hibikino 808-0196, Japan, Matsuki, Moe, Lago, Paula, and Inoue, Sozo

Abstract

type:Journal Article, In this paper, we address Zero-shot learning for sensor activity recognition using word embeddings. The goal of Zero-shot learning is to estimate an unknown activity class (i.e., an activity that does not exist in a given training dataset) by learning to recognize components of activities expressed in semantic vectors. The existing zero-shot methods use mainly 2 kinds of representation as semantic vectors, attribute vector and embedding word vector. However, few zero-shot activity recognition methods based on embedding vector have been studied; especially for sensor-based activity recognition, no such studies exist, to the best of our knowledge. In this paper, we compare and thoroughly evaluate the Zero-shot method with different semantic vectors: (1) attribute vector, (2) embedding vector, and (3) expanded embedding vector and analyze their correlation to performance. Our results indicate that the performance of the three spaces is similar but the use of word embedding leads to a more efficient method, since this type of semantic vector can be generated automatically. Moreover, our suggested method achieved higher accuracy than attribute-vector methods, in cases when there exist similar information in both the given sensor data and in the semantic vector; the results of this study help select suitable classes and sensor data to build a training dataset., source:https://doi.org/10.3390/s19225043

Published
2020

110. A Deep Learning Approach to generate Beethoven's 10th Symphony

Author

Muñoz Lago, Paula and Méndez Pozo, Gonzalo

Subjects
Informática
Abstract

Luidwig van Beethoven composed his symphonies between 1799 and 1825, when he was writing his Tenth symphony. As we dispose of a great amount of data belonging to his work, the purpose of this project is to work on the possibility of extracting patterns on his compositional model and generate what would have been his last symphony, the Tenth. Computational creativity is an Artificial Intelligence field which is still being developed. One of its subfields is music generation, to which this project belongs. Also, there is an open discussion about the belonging of the creativity, to the machine or the programmer. Firstly we have extracted all the symphonies' scores information, structuring them by instrument. Then we have used Deep Learning techniques to extract knowledge from the data and later generate new music. The neural network model is built based on the Long Short-Therm Memory (LSTM) neural networks, which are distinguished from others since these ones contain a memory module. After training the model and predict new scores, the generated music has been analyzed by comparing the input data with the results, and establishing differences between the generated outputs based on the training data used to obtain them. The result's structure depends on the symphonies used for training, so obtained music presents Beethoven's style characteristics.

Published
2019

111. Supplemental_Material – Supplemental material for Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic activity in patients with moderate-to-severe ulcerative colitis treated with golimumab

Author

Magro, Fernando, Lopes, Susana, Silva, Marco, Coelho, Rosa, Portela, Francisco, Branquinho, Diogo, Correia, Luís, Fernandes, Samuel, Cravo, Marília, Caldeira, Paulo, Sousa, Helena Tavares De, Patita, Marta, Lago, Paula, Ramos, Jaime, Afonso, Joana, Redondo, Isabel, Machado, Patrícia, Philip, George, Lopes, Joanne, and Carneiro, Fátima

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplemental_Material for Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic activity in patients with moderate-to-severe ulcerative colitis treated with golimumab by Fernando Magro, Susana Lopes, Marco Silva, Rosa Coelho, Francisco Portela, Diogo Branquinho, Luís Correia, Samuel Fernandes, Marília Cravo, Paulo Caldeira, Helena Tavares de Sousa, Marta Patita, Paula Lago, Jaime Ramos, Joana Afonso, Isabel Redondo, Patrícia Machado, George Philip, Joanne Lopes and Fátima Carneiro in Therapeutic Advances in Gastroenterology

Published
2019
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112. Supplementary_Material – Supplemental material for Accuracy of the new rapid test for monitoring adalimumab levels

Author

Rocha, Cátia, Afonso, Joana, Lago, Paula, Arroja, Bruno, Vieira, Ana I., Dias, Claudia C., and Magro, Fernando

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_Material for Accuracy of the new rapid test for monitoring adalimumab levels by Cátia Rocha, Joana Afonso, Paula Lago, Bruno Arroja, Ana I. Vieira, Claudia C. Dias and Fernando Magro in Therapeutic Advances in Gastroenterology

Published
2019
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113. Supplementary_Table_1 – Supplemental material for What forecasting the prevalence of inflammatory bowel disease may tell us about its evolution on a national scale

Author

Santiago, Mafalda, Magro, Fernando, Correia, Luís, Portela, Francisco, Ministro, Paula, Lago, Paula, and Dias, Cláudia Camila

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_Table_1 for What forecasting the prevalence of inflammatory bowel disease may tell us about its evolution on a national scale by Mafalda Santiago, Fernando Magro, Luís Correia, Francisco Portela, Paula Ministro, Paula Lago and Cláudia Camila Dias in Therapeutic Advances in Gastroenterology

Published
2019
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115. Rapid test detection of anti-infliximab antibodies: performance comparison with three different immunoassays

Author

Rocha, Cátia, primary, Lago, Paula, additional, Fernandes, Samuel, additional, Correia, Luís, additional, Portela, Francisco, additional, Vieira, Ana Isabel, additional, Patita, Marta, additional, Arroja, Bruno, additional, Ministro, Paula, additional, Alves, Catarina, additional, Dias, Cláudia Camila, additional, and Magro, Fernando, additional

Published
2020
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118. Nurse care activity recognition challenge

Author

Lago, Paula, primary, Alia, Sayeda Shamma, additional, Takeda, Shingo, additional, Mairittha, Tittaya, additional, Mairittha, Nattaya, additional, Faiz, Farina, additional, Nishimura, Yusuke, additional, Adachi, Kohei, additional, Okita, Tsuyoshi, additional, Charpillet, François, additional, and Inoue, Sozo, additional

Published
2019
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122. Sexual Quality of Life in Inflammatory Bowel Disease: A Multicenter, National-Level Study

Author

Roseira, Joana, primary, Magro, Fernando, primary, Fernandes, Samuel, primary, Simões, Carolina, primary, Portela, Francisco, primary, Vieira, Ana Isabel, primary, Patita, Marta, primary, Leal, Carina, primary, Lago, Paula, primary, Caldeira, Paulo, primary, Gago, Tânia, primary, Currais, Pedro, primary, Dias, Cláudia Camila, primary, Santiago, Mafalda, primary, Dias, Sandra, primary, and Tavares de Sousa, Helena, primary

Published
2019
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123. Mo1868 – Methylation Patterns in Dysplasia in Inflammatory Bowel Disease Patients

Author

Rosa, Isadora, primary, Silva, Patrícia, additional, Mata, Sara, additional, Magro, Fernando, additional, Carneiro, Fatima, additional, Peixoto, Armando, additional, Silva, Marco, additional, Sousa, Helena T., additional, Parra, José, additional, Barosa, Rita, additional, Vieira, Ana, additional, Brito, Maria J., additional, Lago, Paula M., additional, Coelho, André, additional, Moleiro, Joana, additional, Silva, João Pereira da, additional, Fonseca, Ricardo, additional, Albuquerque, Cristina, additional, and Pereira, António Dias, additional

Published
2019
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125. Sa1867 – Sexual Quality of Life in Inflammatory Bowel Disease – a Multicentre, National-Level Study

Author

Roseira, Joana, primary, Magro, Fernando, additional, Fernandes, Samuel R., additional, Simões, Carolina, additional, Portela, Francisco, additional, Vieira, Ana, additional, Patita, Marta, additional, Leal, Carina, additional, Lago, Paula M., additional, Caldeira, Paulo, additional, Gago, Tania, additional, Currais, Pedro, additional, Dias, Camila, additional, and Sousa, Helena T., additional

Published
2019
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127. A Deep Learning Approach to generate Beethoven's 10th Symphony

Author

Méndez Pozo, Gonzalo, Muñoz Lago, Paula, Méndez Pozo, Gonzalo, and Muñoz Lago, Paula

Abstract

Luidwig van Beethoven composed his symphonies between 1799 and 1825, when he was writing his Tenth symphony. As we dispose of a great amount of data belonging to his work, the purpose of this project is to work on the possibility of extracting patterns on his compositional model and generate what would have been his last symphony, the Tenth. Computational creativity is an Artificial Intelligence field which is still being developed. One of its subfields is music generation, to which this project belongs. Also, there is an open discussion about the belonging of the creativity, to the machine or the programmer. Firstly we have extracted all the symphonies' scores information, structuring them by instrument. Then we have used Deep Learning techniques to extract knowledge from the data and later generate new music. The neural network model is built based on the Long Short-Therm Memory (LSTM) neural networks, which are distinguished from others since these ones contain a memory module. After training the model and predict new scores, the generated music has been analyzed by comparing the input data with the results, and establishing differences between the generated outputs based on the training data used to obtain them. The result's structure depends on the symphonies used for training, so obtained music presents Beethoven's style characteristics., Luidwig van Beethoven compuso sus sinfonías entre 1799 y 1825, cuando estaba componiendo su décima sinfonía. Como disponemos de una gran cantidad de datos provenientes de su obra, el objetivo de este proyecto es investigar en la posibilidad de extraer patrones en su modelo composicional y generar lo que hubiese sido su última sinfonía, la Décima. La creatividad computacional es un campo de la Inteligencia Artificial que se encuentra todavía en desarrollo, uno de los campos que abarca la creatividad computacional es la generación de música, en el que se encuentra este proyecto. Además, existe un debate abierto sobre si las máquinas pueden llegar a ser creativas, o el mérito debe atribuirse al programador. En primer lugar hemos extraído la información de las partituras de todas sus sinfonías, estructurándolas por instrumento. A continuación hemos utilizado técnicas de aprendizaje automático para extraer conocimiento de los datos y posteriormente predecir música. El modelo neuronal se ha basado en las redes neuronales LSTM (Long Short-Therm Memory), que se diferencian del resto dado a que disponen de memoria. Tras entrenar el modelo y predecir nuevas partituras, la música generada ha sido estudiada comparando los datos de entrada con dichos resultados, y estableciendo diferencias entre los resultados obtenidos dependiendo de los datos usados para generarlos. La estructura de los resultados depende de las sinfonías que se han usado para aprender de ellas, por lo que la música obtenida presenta características reconocibles del estilo de Beethoven.

Published
2019

128. A Hybrid Model Using Hidden Markov Chain and Logic Model for Daily Living Activity Recognition

Author

Graduate School of Engineering, Kyushu Institute of Technology, 804-8550 Kitakyushu, Japan, Lago, Paula, Inoue, Sozo, Graduate School of Engineering, Kyushu Institute of Technology, 804-8550 Kitakyushu, Japan, Lago, Paula, and Inoue, Sozo

Abstract

type:Conference Paper, We detail the solution to the UCAmI Cup Challenge to recognizing on going activities at home from sensor measurements. We use binary sensors and proximity sensor measurements for the recognition. We use an hybrid strategy, combining a probabilistic model and a definition-based model. The former consists of a Hidden Markov Model using the result of a neural network as emission probabilities. It is trained with the labelled data provided by the Cup. The latter approach takes advantage of the descriptions provided for each of the activities which are expressed in logical statements based on the sensors states. We then combine the results with a weighted average. We compare the performance of each individual strategy and of the combined strategy., 12th International Conference on Ubiquitous Computing and Ambient Intelligence (UCAmI 2018), 4–7 December 2018, Punta Cana, Dominican Republic, source:https://doi.org/10.3390/proceedings2191266

Published
2019

129. Composite outcomes in observational studies of ulcerative colitis: A systematic review and meta‐analysis

Author

Magro, Fernando, Alves, Catarina, Santiago, Mafalda, Ministro, Paula, Lago, Paula, Correia, Luís, Gonçalves, Raquel, Carvalho, Diana, Portela, Francisco, Dias, Cláudia Camila, Dignass, Axel, Danese, Silvio, Peyrin‐Biroulet, Laurent, Estevinho, Maria Manuela, and Moreira, Paula

Abstract

Ulcerative colitis (UC) has been the focus of numerous observational studies over the years and a common strategy employed in their design is the use of composite and aggregate outcomes. This systematic review and meta‐analysis aims to identify composite and aggregate outcomes of observational studies in UC and to evaluate how the number and type of variables included and the length of follow‐up affect the frequency of patients that achieve these outcomes. A systematic literature search was carried out using MEDLINE [via PubMed], Scopus, and Web of Science online databases. Observational studies that included UC patients and reported composite or aggregate outcomes were identified. A set of variables considered to be representative of progressive or disabling UC was defined, the proportion of patients attaining the outcomes was determined and a random‐effects meta‐analysis was performed by dividing the identified studies into subgroups according to different criteria of interest. A total of 10,264 records were identified in the systematic search, of which 33 were retained for qualitative analysis and 20 were included in the meta‐analysis. The mean frequency for composite outcomes was 0.363 [95% confidence interval (CI) 0.323‐0.403]. The frequency of composite outcome for the subgroup of studies that included the variable “Biologics” was significantly higher than for those in which this variable was not reported [0.410; 95% CI 0.364‐0.457 versus 0.298; 95% CI 0.232‐0.364; p= 0.006]. Composite outcomes were also more frequent as the follow‐up duration increased. The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported. Moreover, longer follow‐up periods are associated with higher frequencies of composite outcomes. The evidence provided here is useful for the design of future observational studies of UC that aim to maximize the frequency of patients that achieve composite outcomes. Summarize the established knowledge on this subjectObservational studies have become a valuable source of information but also present a remarkable heterogeneity.The inconsistency on the reported outcomes between individual studies and the potential for reporting biases has led to calls for the development of core outcome sets (COS).What are the significant and/or new findings of this study?This is the first systematic review and meta‐analysis of outcomes in observational studies of Ulcerative colitis (UC).The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported and on the follow‐up duration.Reporting of the variable “Biologics” significantly increased the frequency of composite outcomes.These findings may be useful for the design of future observational studies of UC. Summarize the established knowledge on this subject Observational studies have become a valuable source of information but also present a remarkable heterogeneity. The inconsistency on the reported outcomes between individual studies and the potential for reporting biases has led to calls for the development of core outcome sets (COS). What are the significant and/or new findings of this study? This is the first systematic review and meta‐analysis of outcomes in observational studies of Ulcerative colitis (UC). The frequency of composite outcomes in observational studies of UC is dependent on the specific identity of the variables being reported and on the follow‐up duration. Reporting of the variable “Biologics” significantly increased the frequency of composite outcomes. These findings may be useful for the design of future observational studies of UC.

Published
2022
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130. Clinical, Endoscopic and Histological Outcomes in Induction of Moderate-to-Severe Ulcerative Colitis: A Systematic Review with Meta-Analysis.

Author

Magro, Fernando, Estevinho, Maria Manuela, Dias, Cláudia Camila, Correia, Luís, Lago, Paula, Ministro, Paula, Portela, Francisco, Feakins, Roger, Danese, Silvio, and Peyrin-Biroulet, Laurent

Abstract

Background and Aims Interest in histology for ulcerative colitis [UC] has increased recently. This systematic review and meta-analysis aims to assess, for the first time, whether histological outcomes are more informative than endoscopic and clinical outcomes in distinguishing the impact of intervention over placebo in induction trials. Methods MEDLINE, ScienceDirect and Cochrane Central Register of Controlled Trials were searched to identify randomized placebo-controlled trials [RCTs] enrolling moderate-to-severe UC patients. Studies were assessed using the Quality Assessment Tool for Studies with Diverse Designs. We analysed the pooled proportion of patients achieving clinical, endoscopic and histological remission and response after a pharmacological intervention and compared the results with those of placebo-treated patients by using a random-effects model. Results From 889 identified records, 13 RCTs were included. The odds ratio [OR] for remission was higher in patients receiving intervention than in those under placebo for clinical (OR 2.13, 95% confidence interval [CI] 1.33–3.43), endoscopic [OR 1.46, 95% CI 0.19–11.18] and histological remission [OR 1.85, 95% CI 1.20–2.84]. Significant differences were observed for all response outcomes [clinical: OR 2.27, 95% CI 1.84–2.85; endoscopic: OR 2.16, 95% CI 1.51–3.10; histological: OR 3.63, 95% CI, 1.41–9.36]. No significant heterogeneity existed; no subgroup effects were found for duration of the induction or histological scale [ p  > 0.05]. Clinical and histological remission and endoscopic response were concordant in discriminating interventions from placebo. Conclusion Histological outcomes are informative in trials of moderate-to-severe UC. Further studies analysing histology at the end of induction are needed to confirm its relevance in distinguishing the efficacy of an intervention over placebo in comparison to clinical and endoscopic outcomes and to explore its prognostic value. [ABSTRACT FROM AUTHOR]

Published
2021
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131. Contextualized behavior patterns for change reasoning in Ambient Assisted Living: A formal model

Author

LAGO, Paula, Jiménez-Guarín, Claudia, Roncancio, Claudia, Systèmes d’Information - inGénierie et Modélisation Adaptables (SIGMA), Laboratoire d'Informatique de Grenoble (LIG ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and Universidad de los Andes [Bogota] (UNIANDES)

Subjects
[INFO]Computer Science [cs]
Abstract

International audience; Ambient Assisted Living, smart environments and technology used for elder care, increases independent living time and cuts long-term care costs. An important requirement for these systems is detecting and informing about abnormal behavior in users' routines. Still, routines may change when certain context conditions hold, which does not mean these changes should concern caregivers. However, changes due to context conditions are not often considered in current proposals. In this paper, we formalize the main concepts related to activities in AAL and we introduce contextualized behavior patterns, a long-term behavior model that considers variability due to context. We adopt a semantic similarity that allows to better detect behavior changes and to understand what makes an observation of daily living different from expected patterns. The results of the experience with three public data sets are promising. Keywords: behavior analysis · behavioral patterns · activities of daily living · elder care · context awareness · long term behavior modeling

Published
2017
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134. Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic activity in patients with moderate-to-severe ulcerative colitis treated with golimumab

Author

Magro, Fernando, primary, Lopes, Susana, additional, Silva, Marco, additional, Coelho, Rosa, additional, Portela, Francisco, additional, Branquinho, Diogo, additional, Correia, Luís, additional, Fernandes, Samuel, additional, Cravo, Marília, additional, Caldeira, Paulo, additional, Tavares de Sousa, Helena, additional, Patita, Marta, additional, Lago, Paula, additional, Ramos, Jaime, additional, Afonso, Joana, additional, Redondo, Isabel, additional, Machado, Patrícia, additional, Philip, George, additional, Lopes, Joanne, additional, and Carneiro, Fátima, additional

Published
2019
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135. Methylation patterns in dysplasia in inflammatory bowel disease patients.

Author

Rosa, Isadora, Silva, Patrícia, da Mata, Sara, Magro, Fernando, Carneiro, Fátima, Peixoto, Armando, Silva, Marco, Sousa, Helena T., Roseira, Joana, Parra, José, Barosa, Rita, Vieira, Ana, Brito, Maria José, Lago, Paula, Coelho, André, Moleiro, Joana, Pereira da Silva, João, Fonseca, Ricardo, Albuquerque, Cristina, and Dias Pereira, A.

Subjects
INFLAMMATORY bowel diseases, METHYLATION, ULCERATIVE colitis, COLON cancer, DNA methylation
Abstract

Background and aims: Inflammatory Bowel Disease (IBD) with colonic involvement increases colorectal cancer risk. However, the distinction between IBD related and sporadic dysplasia in IBD patients is difficult. Some data favors the importance of abnormal DNA methylation in IBD-related carcinogenesis. We aimed to define methylation patterns in patients with colonic cancer or dysplasia diagnosis following an IBD diagnosis. Methods: Multicentric cross-sectional study-91 samples from colonic mucosa with/without dysplasia from 9 patients with IBD-related dysplasia/cancer and 26 patients with IBD and sporadic dysplasia/cancer were included. Methylation patterns of CpG islands in the promoter regions of 67 genes were studied by Methylation-specific Multiplex Ligation-dependent Probe Amplification. Results: Mean age at IBD diagnosis: 42 ± 16 years;at dysplasia diagnosis: 56 ± 14 years. Twenty-ninepatients had ulcerative colitis. Twenty-five patients had at least 1 lesion endoscopically described as adenoma-like, 4 at least 1 non-adenoma like, 3 had cancer and 3 had dysplasia in flat mucosa. No patient had both adenoma-like and non-adenoma-like lesions. Patients with an IBD-related lesion were significantly younger at IBD diagnosis (p =.003) and at dysplasia/cancer diagnosis (p =.039). Promoter methylation of IGF2, RARB, ESR1, CHFR, CDH13, WT1, GATA5, WIF1genes was significantly associated to dysplasia/cancer; methylation of MSH6, TIMP3 was significantly associated to IBD-related dysplasia/cancer. Promoter methylation of MSH6, MSH3, RUNX3, CRABP1, TP73, RARB, CDH13, PAX5, WT1, THBS1, TP53, SFRP1, WIF1, APAF1,BCL2 genes was significantly associated to active IBD. Conclusions: Methylation analysis, namely of MSH6, may contribute to the classification of dysplastic lesions in IBD– to be further tested in prospective studies. [ABSTRACT FROM AUTHOR]

Published
2020
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143. Su1801 - Different Histological Indexes for the Assessment of Ulcerative Colitis Activity

Author

Magro, Fernando, primary, Lopes, Joanne D., additional, Borralho, Paula, additional, Lopes, Susana, additional, Coelho, Rosa, additional, Cotter, José, additional, de Castro, Francisca Dias, additional, Sousa, Helena T., additional, Lago, Paula M., additional, Salgado, Marta, additional, Andrade, Patricia, additional, Vieira, Ana, additional, Figueiredo, Pedro, additional, Caldeira, Paulo, additional, Sousa, A, additional, Duarte, Maria A, additional, Ávila, Filipa, additional, da Silva, João Pereira, additional, Moleiro, Joana, additional, Mendes, Sofia, additional, Giestas, Silvia, additional, Ministro, Paula, additional, Sousa, Paula, additional, Gonçalves, Raquel, additional, Gonçalves, Bruno M., additional, Oliveira, Ana Maria, additional, Rosa, Isadora, additional, Rodrigues, Marta, additional, Chagas, Cristina, additional, Torres, Joana, additional, Dias, Camila, additional, Afonso, Joana, additional, Geboes, Karel, additional, and Carneiro, Fatima, additional

Published
2018
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146. Clinical performance of an infliximab rapid quantification assay

Author

Magro, Fernando, primary, Afonso, Joana, additional, Lopes, Susana, additional, Coelho, Rosa, additional, Gonçalves, Raquel, additional, Caldeira, Paulo, additional, Lago, Paula, additional, de Sousa, Helena Tavares, additional, Ramos, Jaime, additional, Gonçalves, Ana Rita, additional, Ministro, Paula, additional, Rosa, Isadora, additional, Meira, Tânia, additional, Andrade, Patrícia, additional, Soares, João-Bruno, additional, Carvalho, Diana, additional, Sousa, Paula, additional, Vieira, Ana Isabel, additional, Lopes, Joanne, additional, Dias, Cláudia Camila, additional, Geboes, Karel, additional, and Carneiro, Fátima, additional

Published
2017
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147. Calprotectin and the Magnitude of Antibodies to Infliximab in Clinically-stable Ulcerative Colitis Patients are More Relevant Than Infliximab Trough Levels and Pharmacokinetics for Therapeutic Escalation

Author

Magro, Fernando, primary, Afonso, Joana, additional, Lopes, Susana, additional, Coelho, Rosa, additional, Gonçalves, Raquel, additional, Caldeira, Paulo, additional, Lago, Paula, additional, de Sousa, Helena Tavares, additional, Ramos, Jaime, additional, Gonçalves, Ana Rita, additional, Ministro, Paula, additional, Rosa, Isadora, additional, Vieira, Ana Isabel, additional, Andrade, Patrícia, additional, Soares, João-Bruno, additional, Carvalho, Diana, additional, Sousa, Paula, additional, Meira, Tânia, additional, Lopes, Joanne, additional, Moleiro, Joana, additional, Dias, Cláudia Camila, additional, Falcão, Amílcar, additional, Geboes, Karel, additional, and Carneiro, Fatima, additional

Published
2017
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148. Positioning AeromonasInfection in Inflammatory Bowel Disease: A Retrospective Analysis

Author

Pereira Guedes, Tiago, Alves Silva, Joana, Neves, Sara, Falcão, Daniela, Costa, Paula, Lago, Paula, Pedroto, Isabel, and Salgado, Marta

Abstract

Background and Aim:Aeromonasare Gram-negative rods known to cause a spectrum of diseases. Inflammatory bowel disease (IBD) is an idiopathic complex condition resulting from interaction of multiple factors. Aeromonas infection in association with IBD is still largely unknown. We aim to look for the significance of Aeromonasinfection and for significant differences between IBD and non-IBD patients. Methods:A retrospective observational analysis was performed of all patients positive for Aeromonasin stool cultures, during a 10-year period, from a tertiary and university hospital. Results:Fifty patients were included, 56% male with a mean age of 42.1 years. Thirty-eight (76%) were non-IBD and 12 (24%) IBD patients. IBD patients were more frequently under immunosuppressors. Two patients were asymptomatic and 44% developed mild, 44% moderate, and 16.7% severe infection. The main strains isolated were Aeromonashydrophila/caviae. Bacterial co-isolation was found in 4 non-IBD and histological findings of cytomegalovirus in 2 IBD patients. Non-IBD patients presented more frequently with fever and IBD patients with bloody diarrhea and abdominal pain. There was higher tendency for severe infection rate in IBD patients with higher antimicrobial therapy use. Steroids were exclusively used in the IBD group. From IBD, 4 patients had the diagnosis of ulcerative colitis and 9 of Crohn’s disease with colonic involvement. Of these patients, 5 received IBD diagnosis after the acute episode of Aeromonasinfection. Conclusions:Clinical presentation of Aeromonasinfection differs between IBD and non-IBD patients. Non-IBD patients had milder severity of infection with less use of antibiotics. Aeromonasinfection seems to greatly contribute to IBD manifestation.

Published
2021
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149. Crohn's disease and systemic lupus erythematosus: A rare and challenging association

Author

João-Magalhães,Maria, Lago,Paula, and Pedroto,Isabel

Subjects
Adult, Crohn’s disease, Systemic lupus erythematosus, Crohn Disease, immune system diseases, Humans, Lupus Erythematosus, Systemic, lcsh:Diseases of the digestive system. Gastroenterology, Female, lcsh:RC799-869, skin and connective tissue diseases, Infliximab
Abstract

Submitted by José Pereira (jro.pereira@gmail.com) on 2016-07-19T10:38:27Z No. of bitstreams: 1 Crohn’s disease and systemic lupus.pdf: 549795 bytes, checksum: fcc33b4fd4ffa9ac1fe00c18ceb5ddcf (MD5) Made available in DSpace on 2016-07-19T10:38:27Z (GMT). No. of bitstreams: 1 Crohn’s disease and systemic lupus.pdf: 549795 bytes, checksum: fcc33b4fd4ffa9ac1fe00c18ceb5ddcf (MD5) Previous issue date: 2015-06

Published
2015

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