505 results on '"Langdahl, B"'
Search Results
102. A Large Human Centrifuge for Exploration end Explotation Research
- Author
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van Loon, J. J. W. A., Baeyens, Jp, Berte, J., Blanc, S., Braak, L., Bok, K., Bos, J., Boyle, R., Bravenoer, N., Eekhoff, M., Chouker, A., Clement, G., Cras, P., Cross, Cusaud, DE ANGELIS, Marco, de Dreu, C., Delavaux, T., Delfos, R., Poelma, C., Denise, P., Felsenberg, D., Fong, K., Fuller, C., Grillner, Groen, E., Harlaar, Heer, M., Neuss, Heglund, N., Hinghofer Szalkay, H., Goswami, N., Graz, Hughes Fulfordn, M., Iwase, S., Karemaker, J. M., Langdahl, B., Linnarsson, D., Lüthen, C., Manzey, Monici, M., Mulder, E., Narici, M., Norsk, P., Paloski, W., Prisk, K., Rutten, M., Singer, Stegeman, D., Stephan, A., Stienen, G., Suedfeld, P., Tesch, P., Ullrich, O., Van den Berg, R., Van de Heyning, P., Vautmans, L., Veyt, J., Vico, L., Woodward, Young, L., and Wuyts, F.
- Subjects
Hypergravity • Artificial gravity • Microgravity • Weightlessness • Centrifuge • Gravity continuum • Mars • Moon • Human exploration • Human Hypergravity Habitat - Published
- 2011
103. Association analyses of 47,500 individuals identifies six fracture loci and 82 BMD loci clustering in biological pathways that regulate osteoblast and osteoclast activity
- Author
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Estrada, K., Evangelou, E., Hsu, Y. H., Styrkarsdottir, U., Liu, C. T., Moayyeri, A., Kaptoge, S., Duncan, E., Amin, N., Kiel, D., Karasik, D., Albagha, O. M., Brown, M., Spector, T. D., Zillikens, M. C., Ohlsson, C., Thorleifsson, G., Reeve, J., Vandenput, L., Pettersson, U., O'Neill, T., Riancho, J. A., Ijunggren, O., Rousseau, F., Leslie, W. D., Obermayer-Pietsch, B., Alonso, N., Langdahl, B., Nogues, X., Prince, R., Lips, P., Cheng, S., Marc, J., Kollia, P., Brandi, M. L., Hocking, L., Khusnutdina, E., Cooper, C., Lehtimaki, T., Jackson, R., Koh, J. M., Minster, R. L., Yerges-Armstrong, L., Richards, B., Glazer, N., Kung, A., Koller, D., Evans, D., Ioannidis, J., Ralston, S. H., Uitterlinden, A. G., Rivadeneira, F., Aogc, Gefos, and Genomos Consortia
- Abstract
Bone
- Published
- 2011
104. New genetic loci link adipose and insulin biology to body fat distribution
- Author
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Shungin, D, Winkler, T, Croteau Chonka, D, Ferreira, T, Locke, A, Mägi, R, Strawbridge, R, Pers, T, Fischer, K, Justice, A, Workalemahu, T, Wu, J, Buchkovich, M, Heard Costa, N, Roman, T, Drong, A, Song, C, Gustafsson, S, Day, F, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, J, Scherag, A, Vedantam, S, Wood, A, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, C, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg Gresham, J, Buyske, S, Demirkan, A, Ehret, G, Feitosa, M, Goel, A, Jackson, A, Johnson, T, Kleber, M, Kristiansson, K, Mangino, M, Leach, I, Medina Gomez, C, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Stanca'Kova', A, Sung, Y, Tanaka, T, Teumer, A, Van Vliet Ostaptchouk, J, Yengo, L, Zhang, W, Albrecht, E, Ärnlöv, J, Arscott, G, Bandinelli, S, Barrett, A, Bellis, C, Bennett, A, Berne, C, Blüher, M, Böhringer, S, Bonnet, F, Böttcher, Y, Bruinenberg, M, Carba, D, Caspersen, I, Clarke, R, Daw, E, Deelen, J, Deelman, E, Delgado, G, Doney, A, Eklund, N, Erdos, M, Estrada, K, Eury, E, Friedrich, N, Garcia, M, Giedraitis, V, Gigante, B, Go, A, Golay, A, Grallert, H, Grammer, T, Gräsler, J, Grewal, J, Groves, C, Haller, T, Hallmans, G, Hartman, C, Hassinen, M, Hayward, C, Heikkilä, K, Herzig, K, Helmer, Q, Hillege, H, Holmen, O, Hunt, S, Isaacs, A, Ittermann, T, James, A, Johansson, I, Juliusdottir, T, Kalafati, I, Kinnunen, L, Koenig, W, Kooner, I, Kratzer, W, Lamina, C, Leander, K, Lee, N, Lichtner, P, Lind, L, Lindström, J, Lobbens, S, Lorentzon, M, Mach, F, Magnusson, P, Mahajan, A, Mcardle, W, Menni, C, Merger, S, Mihailov, E, Milani, L, Mills, R, Moayyeri, A, Monda, K, Mooijaart, S, Mühleisen, T, Mulas, A, Müller, G, Müller Nurasyid, M, Nagaraja, R, Nalls, M, Narisu, N, Glorioso, N, Nolte, I, Olden, M, Rayner, N, Renstrom, F, Ried, J, Robertson, N, Rose, L, Sanna, S, Scharnagl, H, Scholtens, S, Sennblad, B, Seufferlein, T, Sitlani, C, Smith, A, Stirrups, K, Stringham, H, Sundström, J, Swertz, M, Swift, A, Syvänen, A, Tayo, B, Thorand, B, Thorleifsson, G, Tomaschitz, A, Troffa, C, Van Oort, F, Verweij, N, Vonk, J, Waite, L, Wennauer, R, Wilsgaard, T, Wojczynski, M, Wong, A, Zhang, Q, Zhao, J, Brennan, E, Choi, M, Eriksson, P, Folkersen, L, Franco Cereceda, A, Gharavi, A, Hedman, A, Hivert, M, Huang, J, Kanoni, S, Karpe, F, Keildson, S, Kiryluk, K, Liang, L, Lifton, R, Ma, B, Mcknight, A, Mcpherson, R, Metspalu, A, Min, J, Moffatt, M, Montgomery, G, Murabito, J, Nicholson, G, Nyholt, D, Olsson, C, Perry, J, Reinmaa, E, Salem, R, Sandholm, N, Schadt, E, Scott, R, Stolk, L, Vallejo, E, Westra, H, Zondervan, K, Amouyel, P, Arveiler, D, Bakker, S, Beilby, J, Bergman, R, Blangero, J, Brown, M, Burnier, M, Campbell, H, Chakravarti, A, Chines, P, Claudi Boehm, S, Collins, F, Crawford, D, Danesh, J, De Faire, U, De Geus, E, Dörr, M, Erbel, R, Eriksson, J, Farrall, M, Ferrannini, E, Ferrières, J, Forouhi, N, Forrester, T, Franco, O, Gansevoort, R, Gieger, C, Gudnason, V, Haiman, C, Harris, T, Hattersley, A, Heliövaara, M, Hicks, A, Hingorani, A, Hoffmann, W, Hofman, A, Homuth, G, Humphries, S, Hyppönen, E, Illig, T, Jarvelin, M, Johansen, B, Jousilahti, P, Jula, A, Kaprio, J, Kee, F, Keinanen Kiukaanniemi, S, Kooner, J, Kooperberg, C, Kovacs, P, Kraja, A, Kumari, M, Kuulasmaa, K, Kuusisto, J, Lakka, T, Langenberg, C, Le Marchand, L, Lehtimäki, T, Lyssenko, V, Männistö, S, Marette, A, Matise, T, Mckenzie, C, Mcknight, B, Musk, A, Möhlenkamp, S, Morris, A, Nelis, M, Ohlsson, C, Oldehinkel, A, Ong, K, Palmer, L, Penninx, B, Peters, A, Pramstaller, P, Raitakari, O, Rankinen, T, Rao, D, Rice, T, Ridker, P, Ritchie, M, Rudan, I, Salomaa, V, Samani, N, Saramies, J, Sarzynski, M, Schwarz, P, Shuldiner, A, Staessen, J, Steinthorsdottir, V, Stolk, R, Strauch, K, Tönjes, A, Tremblay, A, Tremoli, E, Vohl, M, Völker, U, Vollenweider, P, Wilson, J, Witteman, J, Adair, L, Bochud, M, Boehm, B, Bornstein, S, Bouchard, C, Cauchi, S, Caulfield, M, Chambers, J, Chasman, D, Cooper, R, Dedoussis, G, Ferrucci, L, Froguel, P, Grabe, H, Hamsten, A, Hui, J, Hveem, K, Jöckel, K, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, März, W, Munroe, P, Njolstad, I, Oostra, B, Pedersen, N, Perola, M, Pe'Russe, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, T, Saleheen, D, Sinisalo, J, Slagboom, P, Snieder, H, Spector, T, Thorsteinsdottir, U, Stumvoll, M, Tuomilehto, J, Uitterlinden, A, Uusitupa, M, Van Der Harst, P, Veronesi, G, Walker, M, Wareham, N, Watkins, H, Wichmann, H, Abecasis, G, Assimes, T, Berndt, S, Boehnke, M, Borecki, I, Deloukas, P, Franke, L, Frayling, T, Groop, L, Hunter, D, Kaplan, R, O'Connell, J, Qi, L, Schlessinger, D, Strachan, D, Stefansson, K, Van Duijn, C, Willer, C, Visscher, P, Yang, J, Hirschhorn, J, Zillikens, M, Mccarthy, M, Speliotes, E, North, K, Fox, C, Barroso, I, Franks, P, Ingelsson, E, Heid, I, Loos, R, Cupples, L, Lindgren, C, Mohlke, K, Dastani, Z, Timpson, N, Yuan, X, Henneman, P, Kizer, J, Lyytikainen, L, Fuchsberger, C, Small, K, Coassin, S, Lohman, K, Pankow, J, Uh, H, Wu, Y, Bidulescu, A, Rasmussen Torvik, L, Greenwood, C, Ladouceur, M, Grimsby, J, Manning, A, Mooser, V, Kapur, K, Frants, R, Willemsvan vanDijk, K, Willems, S, Psaty, B, Tracy, R, Brody, J, Chen, I, Viikari, J, Kähönen, M, Evans, D, St Pourcain, B, Sattar, N, Carlson, O, Egan, J, van Heemst, D, Kedenko, L, Nuotio, M, Loo, B, Kanaya, A, Haun, M, Klopp, N, Katsareli, E, Couper, D, Duncan, B, Kloppenburg, M, Borja, J, Musani, S, Guo, X, Semple, R, Teslovich, T, Allison, M, Redline, S, Buxbaum, S, Meulenbelt, I, Ballantyne, C, Hu, F, Paulweber, B, Florez, J, Smith, G, Siscovick, D, Kronenberg, F, van Duijn, C, Waterworth, D, Meigs, J, Dupuis, J, Richards, J, Willenborg, C, Thompson, J, Erdmann, J, Goldstein, B, König, I, Cazier, J, Johansson, Å, Hall, A, Lee, J, Grundberg, E, Havulinna, A, Ho, W, Hopewell, J, Eriksson, N, Lundmark, P, Lyytikäinen, L, Rafelt, S, Tikkanen, E, Van Zuydam, N, Voight, B, Ziegler, A, Altshuler, D, Balmforth, A, Braund, P, Burgdorf, C, Cox, D, Dimitriou, M, Do, R, El Mokhtari, N, Fontanillas, P, Hager, J, Han, B, Kang, H, Kessler, T, Knowles, J, Kolovou, G, Langford, C, Lokki, M, Lundmark, A, Meisinger, C, Melander, O, Maouche, S, Nikus, K, Peden, J, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, M, Schäfer, A, Sivananthan, M, Stewart, A, Tan, S, Thorgeirsson, G, van der Schoot, C, Wagner, P, Wells, G, Wild, P, Yang, T, Basart, H, Boerwinkle, E, Brambilla, P, Cambien, F, Cupples, A, de Faire, U, Dehghan, A, Diemert, P, Epstein, S, Evans, A, Ferrario, M, Gauguier, D, Goodall, A, Hazen, S, Holm, H, Iribarren, C, Jang, Y, Kim, H, Laaksonen, R, Ouwehand, W, Parish, S, Park, J, Rader, D, Shah, S, Stark, K, Trégouët, D, Virtamo, J, Wallentin, L, Zimmermann, M, Nieminen, M, Hengstenberg, C, Sandhu, M, Pastinen, T, Hovingh, G, Zalloua, P, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, S, O'Donnell, C, Reilly, M, Collins, R, Kathiresan, S, Roberts, R, Schunkert, H, Pattaro, C, Köttgen, A, Garnaas, M, Böger, C, Chen, M, Tin, A, Taliun, D, Li, M, Gao, X, Gorski, M, Yang, Q, Hundertmark, C, Foster, M, O'Seaghdha, C, Glazer, N, Struchalin, M, Li, G, Johnson, A, Gierman, H, Hwang, S, Atkinson, E, Cornelis, M, Chouraki, V, Holliday, E, Sorice, R, Deshmukh, H, Ulivi, S, Chu, A, Murgia, F, Trompet, S, Imboden, M, Kollerits, B, Pistis, G, Launer, L, Aspelund, T, Eiriksdottir, G, Mitchell, B, Schmidt, H, Cavalieri, M, Rao, M, de Andrade, M, Turner, S, Ding, J, Andrews, J, Freedman, B, Döring, A, Kolcic, I, Zemunik, T, Boban, M, Minelli, C, Wheeler, H, Igl, W, Zaboli, G, Wild, S, Wright, A, Ellinghaus, D, Nöthlings, U, Jacobs, G, Biffar, R, Endlich, K, Ernst, F, Kroemer, H, Nauck, M, Stracke, S, Völzke, H, Aulchenko, Y, Polasek, O, Hastie, N, Vitart, V, Helmer, C, Wang, J, Ruggiero, D, Bergmann, S, Nikopensius, T, Province, M, Ketkar, S, Colhoun, H, Robino, A, Giulianini, F, Krämer, B, Portas, L, Ford, I, Buckley, B, Adam, M, Thun, G, Sala, C, Metzger, M, Mitchell, P, Ciullo, M, Kim, S, Gasparini, P, Pirastu, M, Jukema, J, Probst Hensch, N, Toniolo, D, Coresh, J, Schmidt, R, Kardia, S, Curhan, G, Gyllensten, U, Franke, A, Rettig, R, Parsa, A, Goessling, W, Kao, W, de Boer, I, Peralta, C, Akylbekova, E, Kramer, H, van der Harst, P, Arking, D, Franceschini, N, Hernandez, D, Townsend, R, Lumley, T, Kestenbaum, B, Haritunians, T, Waeber, G, Lu, X, Leak, T, Aasarød, K, Skorpen, F, Baumert, J, Devuyst, O, Mychaleckyj, J, Hallan, S, Navis, G, Shlipak, M, Bull, S, Paterson, A, Rotter, J, Beckmann, J, Dreisbach, A, Styrkarsdottir, U, Evangelou, E, Hsu, Y, Duncan, E, Ntzani, E, Oei, L, Albagha, O, Kemp, J, Koller, D, Minster, R, Vandenput, L, Willner, D, Xiao, S, Yerges Armstrong, L, Zheng, H, Alonso, N, Kammerer, C, Kaptoge, S, Leo, P, Wilson, S, Aalto, V, Alen, M, Aragaki, A, Center, J, Dailiana, Z, Duggan, D, Garcia Giralt, N, Giroux, S, Hocking, L, Husted, L, Jameson, K, Khusainova, R, Kim, G, Koromila, T, Kruk, M, Laaksonen, M, Lacroix, A, Lee, S, Leung, P, Lewis, J, Masi, L, Mencej Bedrac, S, Nguyen, T, Nogues, X, Patel, M, Prezelj, J, Scollen, S, Siggeirsdottir, K, Svensson, O, Trummer, O, van Schoor, N, Woo, J, Zhu, K, Balcells, S, Brandi, M, Cheng, S, Christiansen, C, Cooper, C, Frost, M, Goltzman, D, González Macías, J, Karlsson, M, Khusnutdinova, E, Koh, J, Kollia, P, Langdahl, B, Leslie, W, Lips, P, Ljunggren, Ö, Lorenc, R, Marc, J, Mellström, D, Obermayer Pietsch, B, Olmos, J, Pettersson Kymmer, U, Reid, D, Riancho, J, Rousseau, F, Tang, N, Urreizti, R, Van Hul, W, Zarrabeitia, M, Castano Betancourt, M, Herrera, L, Ingvarsson, T, Johannsdottir, H, Kwan, T, Li, R, Luben, R, Medina Gómez, C, Palsson, S, Reppe, S, Sigurdsson, G, van Meurs, J, Verlaan, D, Williams, F, Zhou, Y, Gautvik, K, Raychaudhuri, S, Cauley, J, Clark, G, Cummings, S, Danoy, P, Dennison, E, Eastell, R, Eisman, J, Jackson, R, Jones, G, Khaw, K, Mccloskey, E, Nandakumar, K, Peacock, M, Pols, H, Prince, R, Reid, I, Robbins, J, Sambrook, P, Sham, P, Tylavsky, F, Econs, M, Kung, A, Reeve, J, Streeten, E, Karasik, D, Ralston, S, Ioannidis, J, Kiel, D, Forsblom, C, Isakova, T, Mckay, G, Williams, W, Sadlier, D, Mäkinen, V, Swan, E, Boright, A, Ahlqvist, E, Keller, B, Huang, H, Ahola, A, Fagerholm, E, Gordin, D, Harjutsalo, V, He, B, Heikkilä, O, Hietala, K, Kytö, J, Lahermo, P, Lehto, M, Österholm, A, Parkkonen, M, Pitkäniemi, J, Rosengård Bärlund, M, Saraheimo, M, Sarti, C, Söderlund, J, Soro Paavonen, A, Syreeni, A, Thorn, L, Tikkanen, H, Tolonen, N, Tryggvason, K, Wadén, J, Gill, G, Prior, S, Guiducci, C, Mirel, D, Taylor, A, Hosseini, M, Parving, H, Rossing, P, Tarnow, L, Ladenvall, C, Alhenc Gelas, F, Lefebvre, P, Rigalleau, V, Roussel, R, Tregouet, D, Maestroni, A, Maestroni, S, Falhammar, H, Gu, T, Möllsten, A, Cimponeriu, D, Mihai, I, Mota, M, Mota, E, Serafinceanu, C, Stavarachi, M, Hanson, R, Nelson, R, Kretzler, M, Panduru, N, Gu, H, Brismar, K, Zerbini, G, Hadjadj, S, Marre, M, Lajer, M, Waggott, D, Savage, D, Bain, S, Martin, F, Godson, C, Groop, P, Maxwell, A, Sengupta, S, Peloso, G, Ganna, A, Mora, S, Chang, H, Den Hertog, H, Donnelly, L, Fraser, R, Freitag, D, Gurdasani, D, Kaakinen, M, Kettunen, J, Li, X, Montasser, M, Petersen, A, Saxena, R, Service, S, Sidore, C, Surakka, I, Van den Herik, E, Volcik, K, Asiki, G, Been, L, Bolton, J, Bonnycastle, L, Burnett, M, Cesana, G, Elliott, P, Eyjolfsson, G, Goodarzi, M, Gravito, M, Hartikainen, A, Hung, Y, Jones, M, Kaleebu, P, Kastelein, J, Kim, E, Komulainen, P, Lin, S, Nieminen, T, Nsubuga, R, Olafsson, I, Palotie, A, Papamarkou, T, Pomilla, C, Pouta, A, Ruokonen, A, Seeley, J, Silander, K, Stančáková, A, Tiret, L, van Pelt, L, Wainwright, N, Wijmenga, C, Willemsen, G, Young, E, Bennett, F, Boomsma, D, Bovet, P, Chen, Y, Feranil, A, Freimer, N, Hsiung, C, Järvelin, M, Kesäniemi, A, Koudstaal, P, Krauss, R, Kyvik, K, Martin, N, Meneton, P, Moilanen, L, Njølstad, I, Price, J, Sanghera, D, Sheu, W, Whitfield, J, Wolffenbuttel, B, Ordovas, J, Rich, S, Johnson, L, Larson, M, Levy, D, Newton Cheh, C, O'Reilly, P, Palmas, W, Rice, K, Snider, H, Tobin, M, Verwoert, G, Pihur, V, Heath, S, Sõber, S, Arora, P, Zhang, F, Lucas, G, Milaneschi, Y, Parker, A, Fava, C, Fox, E, Go, M, Sjögren, M, Vinay, D, Alexander, M, Tabara, Y, Shaw Hawkins, S, Whincup, P, Shi, G, Seielstad, M, Sim, X, Nguyen, K, Matullo, G, Gaunt, T, Onland Moret, N, Cooper, M, Platou, C, Org, E, Hardy, R, Dahgam, S, Palmen, J, Kuznetsova, T, Uiterwaal, C, Adeyemo, A, Ludwig, B, Tomaszewski, M, Tzoulaki, I, Palmer, N, Chang, Y, Steinle, N, Grobbee, D, Morrison, A, Najjar, S, Hadley, D, Connell, J, Day, I, Lawlor, D, Lawrence, R, Ongen, H, Li, Y, Young, J, Bis, J, Chaturvedi, N, Islam, M, Jafar, T, Kulkarni, S, Grässler, J, Howard, P, Guarrera, S, Ricceri, F, Emilsson, V, Plump, A, Weder, A, Sun, Y, Scott, L, Peltonen, L, Vartiainen, E, Brand, S, Wang, T, Burton, P, Artigas, M, Dong, Y, Wang, X, Zhu, H, Rudock, M, Heckbert, S, Smith, N, Wiggins, K, Doumatey, A, Shriner, D, Veldre, G, Viigimaa, M, Kinra, S, Prabhakaran, 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- Abstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10-8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
- Published
- 2015
105. Large scale prospective meta-analysis of BMD and fracture in relation to COLIA1 Sp1 polymorphism: The GENOMOS study
- Author
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Ralston, S, Uitterlinden, A, Balcells, S, Brandi, M, Carey, A, Langdahl, B, Lorenc, R, Nogues, X, Obermayer-Pietsch, B, Reeve, J, Reid, D, Pols, H, van Schoor, N, and Ioannidis, J
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- 2005
106. Loci for regulation of bone mineral density in men and women identified by
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Ralston, SH, Galwey, N, McKay, I, Albagha, OM, Cardon, L, Compston, JE, Cooper, C, Duncan, EL, Keen, R, Langdahl, B, McLellan, A, O'Riordan, J, Pols, Huib, Reid, DM, Uitterlinden, André, Wass, JA, Bennett, ST, and Internal Medicine
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- 2005
107. Continuing outcomes relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene
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Martino, S. A, Cauley, J. A. B, Barrett Connor, E. C, Powles, T. J. D, Mershon, J. E, Disch, D. E, Secrest, R. J. E, Cummings, S. R. F, Mautalen, C. A. G, Zanchetta, J. R. H, Hooper, M. J. I, K. W. J, Ng, Prince, R. L. K, Nicholson, G. L, Roberts, A. P. M, Seeman, E. N, Williamson, M. O, Boschitsch, E. P, Leb, G. Q, Body, J. J. R, Devogelaer, J. P. S, Geusens, P. T, Kaufman, J. M. u, Peretz, A. V, Adachi, J. W, Bensen, W. X, Brown, J. P. Y, Cheung, A. Z, Chik, C. Aa, Gee, S. Ab, Hanley, D. Ac, Hawker, G. A. Ad, Hodsman, A. B. Ae, Joyce, C. Af, Monchesky, T. C. Ag, Olszynski, W. P. Ah, Roe, B. Ai, Senikas, V. Aj, Seminoski, K. Ak, Wall, J. Ab, Stepan, J. Al, Hyldstrup, L. Am, Langdahl, B. An, Sorensen, T. H. Ao, Alhava, E. Ap, Kormano, M. Aq, Salmela, P. Ar, Salmi, J. As, Valimaki, M. At, Audran, M. Au, Briancon, D. Av, Delmas, P. Aw, Fardellone, P. Ax, Ribot, C. Ay, De Vernejoul, M. C. Az, Balogh, A. Ba, Julesz, J. Bb, Szuecs, J. Bc, Karsik, A. Bd, Fiore, C. Be, Genazzani, A. R. Bf, Gennari, C. Bg, Isaia, Giovanni Carlo, Melis, G. B. Bi, Nuti, R. Bg, Oriente, P. Bj, Passeri, M. Bk, Sartori, L. Bl, Corea Rotter, R. Bm, Gonzalez, S. Bn, Murillo, A. Bo, Jonker, J. J. Bp, Lips, P. Bq, Mulder, H. Br, Pols, H. A. Bs, Halse, J. I. Bt, Hoiseth, A. Bu, Jorde, R. Bv, Olford, E. S. Bw, Skag, A. Bw, Stakkestad, J. A. Bx, Wist, E. By, Badurski, J. E. Bz, Hoszowski, K. Ca, Ogonowski, J. Cc, Bose, K. Cb, Lee, K. O. Cb, Dzurik, R. Cd, Kocijancic, A. Ce, Cannata Andia, J. B. Cf, Collado, R. C. Cg, Carranza, F. H. Ch, Diez Perez, A. Cf, Escobar Jimenez, F. Ci, Minguella, J. F. Cj, Solan, X. N. Cf, Torres, M. M. Cj, Larsson, K. Ck, and Malströem, D. Cl
- Subjects
Selective Estrogen Receptor Modulators ,Cancer Research ,medicine.medical_specialty ,Antineoplastic Agents, Hormonal ,Breast Neoplasms ,Placebo ,Drug Administration Schedule ,law.invention ,Breast cancer ,Randomized controlled trial ,Double-Blind Method ,Estrogen Receptor Modulators ,law ,Internal medicine ,medicine ,Humans ,Raloxifene ,Osteoporosis, Postmenopausal ,Aged ,Gynecology ,business.industry ,Raloxifene Hydrochloride ,Incidence ,Patient Selection ,Lasofoxifene ,Middle Aged ,medicine.disease ,United States ,Treatment Outcome ,Oncology ,Selective estrogen receptor modulator ,Female ,business ,Tamoxifen ,medicine.drug - Abstract
Background: The randomized, double-blind Multiple Outcomes of Raloxifene Evaluation (MORE) trial found that 4 years of raloxifene therapy decreased the incidence of invasive breast cancer among postmenopausal women with osteoporosis by 72% compared with placebo. We conducted the Continuing Outcomes Relevant to Evista (CORE) trial to examine the effect of 4 additional years of raloxifene therapy on the incidence of invasive breast cancer in women in MORE who agreed to continue in CORE. Methods: Women who had been randomly assigned to receive raloxifene (either 60 or 120 mg/day) in MORE were assigned to receive raloxifene (60 mg/day) in CORE (n = 3510), and women who had been assigned to receive placebo in MORE continued on placebo in CORE (n = 1703). Breast cancer incidence was analyzed by a log-rank test, and a Cox proportional hazards model was used to compute hazard ratios (HRs) and 95% confidence intervals (CIs). All statistical tests were two-sided. Results: During the CORE trial, the 4-year incidences of invasive breast cancer and estrogen receptor (ER)-positive invasive breast cancer were reduced by 59% (HR = 0.41; 95% CI = 0.24 to 0.71) and 66% (HR = 0.34; 95% CI = 0.18 to 0.66), respectively, in the raloxifene group compared with the placebo group. There was no difference between the two groups in incidence of ER-negative invasive breast cancer during CORE (P = .86). Over the 8 years of both trials, the incidences of invasive breast cancer and ER-positive invasive breast cancer were reduced by 66% (HR = 0.34; 95 % CI = 0.22 to 0.50) and 76% (HR = 0.24; 95% CI = 0.15 to 0.40), respectively, in the raloxifene group compared with the placebo group. During the CORE trial, the relative risk of thromboembolism in the raloxifene group compared with that in the placebo group was 2.17 (95% CI = 0.83 to 5.70). This increased risk, also observed in the MORE trial, persisted over the 8 years of both trials. Conclusions: The reduction in invasive breast cancer incidence continues beyond 4 years of raloxifene treatment in postmenopausal women with osteoporosis. No new safety concerns related to raloxifene therapy were identified during CORE. © Oxford University Press 2004, all rights reserved.
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- 2004
108. Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes
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Ioannidis, JP, Ralston, SH, Bennett, ST, Brandi, ML, Grinberg, D, Karassa, FB, Langdahl, B, van Meurs, Joyce, Mosekilde, L, Scollen, S, Albagha, OM, Bustamante, M, Carey, AH, Dunning, AM, Enjuanes, A, van Leeuwen, Hans, Mavilia, C, Masi, L, McGuigan, FEA, Nogues, X, Pols, Huib, Reid, DM, Schuit, Stephanie, Sherlock, RE, Uitterlinden, André, and Internal Medicine
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Bone Density/*genetics ,Male ,Risk ,Lumbar Vertebrae ,Polymorphism, Genetic ,Genotype ,Femur Neck ,Estrogen Receptor alpha ,Receptors, Estrogen/*genetics ,Middle Aged ,Fractures, Bone ,Haplotypes ,Meta-Analysis as Topic ,Receptors, Estrogen ,Bone Density ,Osteoporosis/*genetics/physiopathology ,Humans ,Osteoporosis ,Female ,Genetic Predisposition to Disease ,Fractures, Bone/epidemiology/*genetics ,Aged ,Microsatellite Repeats - Abstract
CONTEXT: Both bone mineral density (BMD) and fracture risk have a strong genetic component. Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results. OBJECTIVE: To generate large-scale evidence on whether 3 common ESR1 polymorphisms (intron 1 polymorphisms XbaI [dbSNP: rs9340799] and PvuII [dbSNP: rs2234693] and promoter TA repeats microsatellite) and haplotypes thereof are associated with BMD and fractures. DESIGN AND SETTING: Meta-analysis of individual-level data involving standardized genotyping of 18 917 individuals in 8 European centers. MAIN OUTCOME MEASURES: BMD of femoral neck and lumbar spine; all fractures and vertebral fractures by genotype. RESULTS: No between-center heterogeneity was observed for any outcome in any genetic contrast. None of the 3 polymorphisms or haplotypes had any statistically significant effect on BMD in adjusted or unadjusted analyses, and estimated differences between genetic contrasts were 0.01 g/cm2 or less. Conversely, we found significant reductions in fracture risk. In women homozygous for the absence of an XbaI recognition site, the adjusted odds of all fractures were reduced by 19% (odds ratio, 0.81 [95% CI, 0.71-0.93]; P = .002) and vertebral fractures by 35% (odds ratio, 0.65 [95% CI, 0.49-0.87]; P = .003). Effects on fractures were independent of BMD and unaltered in adjusted analyses. No significant effects on fracture risk were seen for PvuII and TA repeats. CONCLUSIONS: ESR1 is a susceptibility gene for fractures, and XbaI determines fracture risk by mechanisms independent of BMD. Our study demonstrates the value of adequately powered studies with standardized genotyping and clinical outcomes in defining effects of common genetic variants on complex diseases. JAMA
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- 2004
109. Lægemiddelinformation: Teripartide - biosyntetisk humant PTH(1-34)
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Brixen, Kim, Christensen, Palle Mark, Ejersted, Charlotte, and Langdahl, B.
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- 2004
110. Study description and baseline characteristics of the population enrolled in a multinational observational study of extended teriparatide use (ExFOS)
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Ljunggren, Östen, Benhamou, C. L., Dekker, J., Kapetanos, G., Kocjan, T., Langdahl, B. L., Napoli, N., Petto, H., Nikolic, T., Lindh, E., Ljunggren, Östen, Benhamou, C. L., Dekker, J., Kapetanos, G., Kocjan, T., Langdahl, B. L., Napoli, N., Petto, H., Nikolic, T., and Lindh, E.
- Abstract
Objective: To better characterize patients who are currently being prescribed teriparatide in Europe, this article describes the study design and baseline characteristics of participants of the Extended Forsteo* Observational Study (ExFOS). Research design and methods: ExFOS is a noninterventional, multicenter, prospective, observational study in men and women with osteoporosis treated with teriparatide during the course of normal clinical practice for up to 24 months and with a post-treatment follow-up of at least 18 months. Main outcome measures: Baseline characteristics, including history of fracture and back pain, and health-related quality of life (HRQoL, assessed using the EuroQol-5 Dimension [EQ-5D]). Results: Of 1607 patients enrolled, 90.9% were women. At baseline, mean (standard deviation [SD]) age was 70.3 (9.8) years, and 85.8% of patients had a history of fracture (64.7% with >= 2 fragility fractures). Of those with historic fractures, 90.8% had vertebral fractures (67.8% had thoracic fractures). The mean (SD) of reported bone mineral density T-scores were -3.0 (1.2), -2.4 (1.0), and -2.5 (0.9) for lumbar spine, total hip (left), and femoral neck (left), respectively. Overall, 39.3% of patients had experienced >= 1 fall during the 12 months before enrollment. At baseline, 11.4% of patients were osteoporosis-treatment naive and 15% were currently using glucocorticoids. The mean (SD) visual analog scale score for back pain during the last month was 50.7 (26.9), and 62.1% of patients experienced daily or almost daily back pain. The median EQ-5D health state value at baseline was 0.62 (first and third quartiles: 0.19, 0.74). Conclusions: Baseline characteristics of the ExFOS study cohort indicate that patients prescribed teriparatide in Europe have severe osteoporosis with highly prevalent vertebral fractures, frequent and disabling back pain, and a poor HRQoL, despite previous pharmacotherapy for osteoporosis. Limitations include non-randomization, l
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- 2014
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111. A functional amino acid substitution in the glucose-dependent insulinotropic polypeptide receptor (GIPR) gene is associated with lower bone mineral density and increased fracture risk
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Torekov, Signe Sørensen, Harsløf, T, Rejnmark, L, Eiken, P, Jensen, J B, Herman, A P, Hansen, T, Pedersen, O, Holst, J J, Langdahl, B L, Torekov, Signe Sørensen, Harsløf, T, Rejnmark, L, Eiken, P, Jensen, J B, Herman, A P, Hansen, T, Pedersen, O, Holst, J J, and Langdahl, B L
- Abstract
CONTEXT: Food ingestion decreases bone resorption, and glucose-dependent insulinotropic polypeptide (GIP) may mediate this effect. Mice overexpressing GIP have increased osteoblast activity and are rescued from age-related bone loss, whereas GIPR knockout mice have decreased cortical bone mass and compromised bone quality. Carriers of the functional variant GIPR Glu354Gln (rs1800437) have higher plasma glucose 2 hours after glucose ingestion, suggesting that the variant encoding GIPR 354Gln decreases the effect of GIP.OBJECTIVE: The objective of the study was to investigate the effect of GIPR Glu354Gln on bone mineral density (BMD) and fracture risk.DESIGN: This was a prospective, comprehensive, cohort study (number NCT00252408).PARTICIPANTS: A total of 1686 perimenopausal women were included.MAIN OUTCOME MEASURES: Dual-energy X-ray absorptiometry was performed at baseline and after 10 years. Incident fractures were recorded during the follow-up and were obtained from the Danish National Patient Registry, giving a total follow-up time of a minimum 16 years.RESULTS: After 10 years, women with the minor frequency C allele of rs1800437 (354Gln) had significantly lower BMD at the femoral neck compared with carriers of the major G-allele (CC: 0.755 ± 0.015 g/cm(2) vs CG: 747 ± 0.005 g/cm(2); GG: 0.766 ± 0.004 g/cm(2), P < .001). Correspondingly, total hip BMD was significantly lower among C allele carriers (CC: 0.881 ± 0.016 g/cm(2); CG: 0.884 ± 0.005 g/cm(2); and GG: 0.906 ± 0.004 g/cm(2), P < .001). Finally, women homozygous for the variant C allele had an increased risk (hazard ratio 1.6, confidence interval 1.0-2.6, P < .05) of nonvertebral fractures.CONCLUSION: This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and BMD and fracture risk. These findings further establish GIP to be involved in the regulation of bone density.
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- 2014
112. Subsequent fracture rates in a nationwide population-based cohort study with a 10-year perspective
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Hansen, L., primary, Petersen, K. D., additional, Eriksen, S. A., additional, Langdahl, B. L., additional, Eiken, P. A., additional, Brixen, K., additional, Abrahamsen, B., additional, Jensen, J.-E. B., additional, Harsløf, T., additional, and Vestergaard, P., additional
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- 2014
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113. SAT0487 Denosumab (DMAB) Effect on Bone Histology and Histomorphometry in Men with Low Bone Mineral Density (BMD): Table 1.
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Dempster, D., primary, Kendler, D.L., additional, Boonen, S., additional, Bolognese, M., additional, Chapurlat, R., additional, Goemaere, S., additional, Hyldstrup, L., additional, Lewiecki, E.M., additional, Miller, P., additional, Yang, Y.-C., additional, Wagman, R., additional, and Langdahl, B., additional
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- 2014
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114. Study description and baseline characteristics of the population enrolled in a multinational observational study of extended teriparatide use (ExFOS)
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Ljunggren, Ö., primary, Benhamou, C. L., additional, Dekker, J., additional, Kapetanos, G., additional, Kocjan, T., additional, Langdahl, B. L., additional, Napoli, N., additional, Petto, H., additional, Nikolić, T., additional, and Lindh, E., additional
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- 2014
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115. The relationship between growth factor mRNA and protein levels in human bone
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Bunger, MH, Andersen, T, Sorensen, L, Oxlund, H, Lind, M, Eriksen, EF, Bunger, C, and Langdahl, B
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- 2002
116. Semiquantitative mRNA measurements of osteoinductive growth factors in human iliac-crest bone:Transcription factor LMP-1 in humans
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Bunger, MH, Andersen, T, Ling, M, Bunger, CE, Eriksen, EF, and Langdahl, B
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- 2002
117. Effects of teriparatide in postmenopausal women with osteoporosis pre-treated with bisphosphonates : 36-month results from the European Forsteo Observational Study
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Jakob, F., Oertel, H., Langdahl, B., Ljunggren, Östen, Barrett, A., Karras, D., Walsh, J. B., Fahrleitner-Pammer, A., Rajzbaum, G., Barker, C., Lems, W. F., Marin, F., Jakob, F., Oertel, H., Langdahl, B., Ljunggren, Östen, Barrett, A., Karras, D., Walsh, J. B., Fahrleitner-Pammer, A., Rajzbaum, G., Barker, C., Lems, W. F., and Marin, F.
- Abstract
Objectives: To describe fracture rates, back pain, and health-related quality of life (HRQoL) in postmenopausal women with osteoporosis and prior bisphosphonate therapy, treated with teriparatide for up to 18 months and followed up for a further 18 months. Design: Prospective, multinational, and observational study. Methods: Data on prior bisphosphonate use, clinical fractures, back pain visual analog scale (VAS), and HRQoL (EQ-5D) were collected over 36 months. Fracture data were summarized in 6-month intervals and analyzed using logistic regression with repeated measures. Changes from baseline in back pain VAS and EQ-VAS were analyzed using a repeated measures model. Results: Of the 1581 enrolled patients with follow-up data, 1161 (73.4%) had a history of prior bisphosphonate use (median duration: 36 months). Of them, 169 (14.6%) sustained >= 1 fracture during 36-month follow-up. Adjusted odds of fracture were significantly decreased at each 6-month interval compared with the first 6 months of teriparatide treatment: 37% decrease in the 12 to ! 18 months period during teriparatide treatment (P=0.03) and a 76% decrease in the 12- to 18-month period after teriparatide was discontinued (P<0.001). Significant reductions in back pain and improvement in HRQoL were observed. Conclusions: Postmenopausal women with severe osteoporosis previously treated with bisphosphonates had a significant reduction in the incidence of fractures compared with the first 6 months of therapy, a reduction in back pain and an improvement in HRQoL during up to 18 months of teriparatide treatment. These outcomes were still evident for at least 18 months after teriparatide was discontinued. The results should be interpreted in the context of an uncontrolled, observational study in a routine clinical setting.
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- 2012
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118. No association between hip geometry and four common polymorphisms associated with fracture: the Danish osteoporosis prevention study
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Nissen, N, Madsen, J S, Bladbjerg, E M, Beck Jensen, J E, Jørgensen, N R, Langdahl, B, Abrahamsen, B, Brixen, K, Nissen, N, Madsen, J S, Bladbjerg, E M, Beck Jensen, J E, Jørgensen, N R, Langdahl, B, Abrahamsen, B, and Brixen, K
- Abstract
Udgivelsesdato: 2009-Apr, Both osteoporosis and hip geometry are independently associated with fracture risk. There is a significant genetic contribution to the risk of osteoporosis, and evidence provided by twin studies has suggested that hip geometry may also in part be genetically programmed. Polymorphisms in a number of genes, including those coding for methylene-tetrahydrofolate reductase (MTHFR c.677C > T), the purinergic P2X(7) receptor (Glu496Ala and Ile568Asn), and the low-density lipoprotein receptor-related protein 5 (LRP5 exon 9 [c.266A > G]), have been associated with an increased fracture incidence and/or reduced bone mineral density (BMD). The aim of the present study was to test whether these polymorphisms influence hip structural geometry in perimenopausal women. The four polymorphisms were genotyped in 800 healthy recently perimenopausal women never using hormone replacement therapy. BMD of the femoral neck was measured using a Hologic QDR-2000 densitometer and femoral neck axis length, neck width, neck shaft angle, and femoral head diameter were measured from the screen images. Genotype frequencies were compatible with Hardy-Weinberg equilibrium. No significant differences between homozygotes for the minor allele and carriers of the common allele regarding parameters of hip geometry were demonstrated. According to the anthropometric characteristics of the subjects, only body height in the MTHFR TT genotype group was significantly different from the combined CT/CC genotype group (P < 0.05). The geometric dimensions of the proximal femur in perimenopausal women are not associated with the MTHFR c.677C > T, P2X(7) (Glu496Ala), P2X(7) (Ile568Asn), and LRP5 exon 9 (c.266A > G) polymorphisms.
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- 2009
119. Telomere shortening during aging of human osteoblasts in vitro and leucocytes in vivo: lack of excessive telomere loss in osteoporotic patients
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Kveiborg, M., Kassem, M., Langdahl, B., Eriksen, E.F., Clark, B.F.C., and Rattan, Suresh
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- 1999
120. Effectiveness and characteristics of multifaceted osteoporosis group education—a systematic review
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Jensen, A. L., primary, Lomborg, K., additional, Wind, G., additional, and Langdahl, B. L., additional
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- 2013
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121. Vitamin D levels in frail elderly patients with a hip fracture
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Abildgaard Pedersen, M., primary, Gregersen, M., additional, Lomholt Langdahl, B., additional, and Skjøde Damsgaard, E.M., additional
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- 2013
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122. OP0248 Inhibition of Sclerostin with Romosozumab in Postmenopausal Women with Low Bone Mineral Density: Phase 2 Trial Results
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McClung, M. R., primary, Grauer, A., additional, Boonen, S., additional, Brown, J. P., additional, Diez-Perez, A., additional, Langdahl, B. L., additional, Reginster, J.-Y., additional, Zanchetta, J. R., additional, Katz, L., additional, Maddox, J., additional, Yang, Y.-C., additional, Libanati, C., additional, and Bone, H. G., additional
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- 2013
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123. Genome-wide association identifies a new susceptibility locus at 4q35 associated with clinical vertebral fractures in post-menopausal women: the GEFOS-GENOMOS consortium
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Alonso, N, primary, Estrada, K, additional, Herrera, L, additional, Kabir, D, additional, Olmos, J M, additional, Sanudo, C, additional, Riancho, J A, additional, Oei, L, additional, Medina-Gomez, M C, additional, Stenkjaer, L, additional, Bjerre, L, additional, Langdahl, B, additional, Brown, M A, additional, Duncan, E L, additional, Sims, M, additional, Kaptoge, S, additional, Reeve, J, additional, Lewis, J, additional, Prince, R, additional, Reppe, S, additional, Olstad, O K, additional, Gautvik, K M, additional, Garcia-Giralt, N, additional, Nogues, X, additional, Mencej-Bedrac, S, additional, Marc, J, additional, del, Pino J, additional, Gonzalez-Sarmiento, R, additional, Wolstein, O, additional, Eisman, J, additional, Feenstra, B, additional, Melbye, M, additional, Albagha, O M E, additional, WTCCC, WTCCC, additional, Davies, G, additional, Starr, J, additional, Deary, I, additional, Quintela, I, additional, Fernandez, C, additional, Carracedo, A, additional, Lucas, G, additional, Elosua, R, additional, Uitterlinden, A G, additional, Rivadeneira, F, additional, and Ralston, S H, additional
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- 2013
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124. Skeletal phenotypes in adult patients with osteogenesis imperfecta-correlations with COL1A1/ COL1A2 genotype and collagen structure.
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Hald, J., Folkestad, L., Harsløf, T., Lund, A., Duno, M., Jensen, J., Neghabat, S., Brixen, K., and Langdahl, B.
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ANTHROPOMETRY ,COLLAGEN ,COLLAGEN diseases ,COMPUTED tomography ,ELECTROPHORESIS ,GENETIC mutation ,OSTEOGENESIS imperfecta ,X-rays ,PHENOTYPES ,BONE density ,CROSS-sectional method ,PHOTON absorptiometry ,GENOTYPES ,ADULTS ,GENETICS - Abstract
Summary: Osteogenesis imperfecta (OI) is characterized by a high fracture rate and great heterogeneity. This cross-sectional study presents skeletal investigations and protein analyses in 85 adult OI patients. We find significant differences in bone mass, architecture, and fracture rate that correlate well with the underlying biochemical and molecular abnormalities. Introduction: OI is a hereditary disease characterized by compromised connective tissue predominantly caused by mutations in collagen type 1 (COL-1) encoding genes. Widespread symptoms reflect the ubiquity of COL-1 throughout the body. The purpose of this study was to improve our understanding of clinical manifestations by investigating anthropometry and skeletal phenotypes (DXA, HRpQCT) in an adult OI population and compare the findings to underlying COL-1 genotype and structure. Methods: The study comprised 85 OI patients aged 45 (19-78) years, Sillence type I ( n = 58), III ( n = 12), and IV ( n = 15). All patients underwent DXA, HRpQCT, spine X-ray, biochemical testing, and anthropometry. COL1A1 and COL1A2 were sequenced and 68 OI causing mutations identified (46 in COL1A1, 22 in COL1A2). Analysis of COL-1 structure (quantitative/qualitative defect) by SDS-PAGE was performed in a subset ( n = 67). Results: A qualitative collagen defect predisposed to a more severe phenotype with reduced aBMD, more fractures, and affected anthropometry compared to patients with a quantitative COL-1 defect ( p < 0.05). HRpQCT revealed significant differences between patients with OI type I and IV. Patients with type I had lower vBMD ( p < 0.005), thinner cortexes ( p < 0.001), and reduced trabecular number ( p < 0.005) compared to patients with type IV indicating that HRpQCT may distinguish type I from type IV better than DXA. Conclusion: The defective collagen in patients with OI has pronounced effects on the skeleton. The classical OI types based on the clinical classification show profound differences in bone mass and architecture and the differences correlate well with the underlying biochemical and molecular collagen abnormalities. [ABSTRACT FROM AUTHOR]
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- 2016
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125. Bone mass, bone turnover and body composition in former hypothyroid patients receiving replacement therapy
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Langdahl, B L, Loft, A G, Eriksen, E F, Mosekilde, L, and Charles, P
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Adult ,Male ,Hypothyroidism/drug therapy ,Calcium/blood ,Organ Size ,Bone and Bones/metabolism ,Middle Aged ,Thyroid Gland/physiopathology ,Bone Density ,Thyroxine/therapeutic use ,Body Composition ,Homeostasis ,Humans ,Female ,Biomarkers ,Aged - Abstract
The aim of the present cross-sectional study was to disclose whether long-term thyroxine replacement therapy (TRT) in primary hypothyroidism causes osteopenia. We compared 36 adult biochemically and clinically euthyroid patients who had received TRT for more than 5 years (mean 13 years) for primary hypothyroidism with 80 sex- and age-matched normal controls. Height, body weight and lean body mass were similar, but the patients had 21% higher fat body mass (p = < 0.01) than their controls. Furthermore, compared to controls the patients had 29% higher serum thyroxine (T4) and 31% higher serum free T4 index (FT4I) levels (p < 0.001), whereas serum triiodothyronine (T3) and FT3I levels were both reduced by 7% (p < 0.05). In the patients, serum TSH was reduced significantly (p < 0.001). No significant differences were observed between patients and normals in regional or total bone mineral content or bone mineral density levels, apart from 20% higher lumbar bone mineral content among the premenopausal patients (p < 0.05). Surprisingly, the mean serum calcium level was slightly elevated (2.38 +/- 0.08 vs 2.33 +/- 0.07 mmol/l, p < 0.001), serum phosphate decreased (1.13 +/- 0.19 vs 1.23 +/- 0.16 mmol/l, p < 0.01) and 24-h renal calcium excretion was reduced by 19% (p < 0.05). No changes were observed in serum magnesium, intact parathyroid hormone or calcitriol. The biochemical markers of bone resorption (serum carboxyterminal telopeptide of type I collagen, renal excretion of hydroxyproline, pyridinoline and deoxypyridinoline) and formation (serum levels of carboxyterminal propeptide of type I procollagen, osteocalcin and total and bone alkaline phosphatase) were similar in the two groups. We conclude that long-term thyroxine replacement therapy in primary hypothyroidism does not exert a negative effect on bone mass or alter bone turnover.
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- 1996
126. Bone mass, bone turnover, calcium homeostasis, and body composition in surgically and radioiodine-treated former hyperthyroid patients
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Langdahl, B L, Loft, A G, Eriksen, E F, Mosekilde, L, and Charles, P
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Adult ,Male ,Hydroxyproline/urine ,Calcium/metabolism ,Hyperthyroidism/physiopathology ,Thyrotropin/blood ,Triiodothyronine/blood ,Calcifediol/blood ,Middle Aged ,Thyroxine/blood ,Bone Density ,Body Composition ,Homeostasis ,Humans ,Female ,Bone Remodeling ,Calcitriol/blood ,Biomarkers ,Aged - Published
- 1996
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127. Bone mass, bone turnover, body composition, and calcium homeostasis in former hyperthyroid patients treated by combined medical therapy
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Langdahl, B L, Loft, A G, Eriksen, E F, Mosekilde, L, and Charles, P
- Subjects
Thyroxine/blood ,Calcium/metabolism ,Hyperthyroidism/physiopathology ,Phosphates/blood ,Thyrotropin/blood ,Triiodothyronine/blood ,Bone Density ,Body Composition ,Homeostasis ,Humans ,Bone Remodeling ,Thyroid Gland/physiopathology ,Biomarkers - Published
- 1996
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128. Treatment with the cathepsin K inhibitor odanacatib in postmenopausal women with low BMD: 5year results of a phase 2 trial
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Resch, H., primary, Binkley, N., additional, Bone, H., additional, Eisman, J.A., additional, Gilchrist, N., additional, Langdahl, B., additional, Portales, J. Rodriguez, additional, Denker, A., additional, Lombardi, A., additional, De Tilleghem, C. Le Bailly, additional, DaSilva, C., additional, Rosenberg, E., additional, and Leung, A., additional
- Published
- 2012
- Full Text
- View/download PDF
129. Functional polymorphisms in the P2X7 receptor gene are associated with osteoporosis
- Author
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Husted, L. B., primary, Harsløf, T., additional, Stenkjær, L., additional, Carstens, M., additional, Jørgensen, N. R., additional, and Langdahl, B. L., additional
- Published
- 2012
- Full Text
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130. Crystal growth in growing bone: Linking nanostructure with mineral density around the epiphyseal growth plate
- Author
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Birkedal⁎, H., primary, Bünger, M.H., additional, Nygaard, J.V., additional, Langdahl, B., additional, Bünger, C.E., additional, Besenbacher, F., additional, and Pedersen, J.S., additional
- Published
- 2012
- Full Text
- View/download PDF
131. Osteoporosis patient education: A way to health maintenance — Update and new insights
- Author
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Jensen⁎, A.L., primary, Langdahl, B., additional, and Lomborg, K., additional
- Published
- 2012
- Full Text
- View/download PDF
132. Evaluating osteoporosis group-education
- Author
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Jensen⁎, A.L., primary, Langdahl, B., additional, and Lomborg, K., additional
- Published
- 2012
- Full Text
- View/download PDF
133. Treatment with the cathepsin K inhibitor odanacatib in postmenopausal women with low BMD: 5year results of a phase 2 trial
- Author
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Langdahl⁎, B., primary, Binkley, N., additional, Bone, H., additional, Gilchrist, N., additional, Resch, H., additional, Rodriguez Portales, J., additional, Lombardi, A., additional, Denker, A., additional, Le Bailly De Tilleghem, C.L.B.D.T., additional, DaSilva, C., additional, Rosenberg, E., additional, and Leung, A., additional
- Published
- 2012
- Full Text
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134. Effects of teriparatide in postmenopausal women with osteoporosis pre-treated with bisphosphonates: 36-month results from the European Forsteo Observational Study
- Author
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Jakob, F, primary, Oertel, H, additional, Langdahl, B, additional, Ljunggren, O, additional, Barrett, A, additional, Karras, D, additional, Walsh, J B, additional, Fahrleitner-Pammer, A, additional, Rajzbaum, G, additional, Barker, C, additional, Lems, W F, additional, and Marin, F, additional
- Published
- 2012
- Full Text
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135. Polymorphisms in the CYP19 and AR genes--relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormone replacement therapy : The Danish Osteoporosis Prevention Study.
- Author
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Tofteng, C L, Kindmark, A, Brändström, H, Abrahamsen, B, Petersen, S, Stiger, F, Stilgren, L S, Jensen, J E B, Vestergaard, P, Langdahl, B L, Mosekilde, L, Tofteng, C L, Kindmark, A, Brändström, H, Abrahamsen, B, Petersen, S, Stiger, F, Stilgren, L S, Jensen, J E B, Vestergaard, P, Langdahl, B L, and Mosekilde, L
- Published
- 2004
136. Two single nucleotide polymorphisms in the CYP17 and COMT Genes--relation to bone mass and longitudinal bone changes in postmenopausal women with or without hormone replacement therapy. The Danish Osteoporosis Prevention Study.
- Author
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Tofteng, C L, Abrahamsen, B, Jensen, J E B, Petersen, S, Teilmann, J, Kindmark, A, Vestergaard, P, Gram, J, Langdahl, B L, Mosekilde, L, Tofteng, C L, Abrahamsen, B, Jensen, J E B, Petersen, S, Teilmann, J, Kindmark, A, Vestergaard, P, Gram, J, Langdahl, B L, and Mosekilde, L
- Published
- 2004
137. The Expression and Regulation of Bone-acting Cytokines in Human Peripheral Adipose Tissue in Organ Culture
- Author
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Harsløf, T., primary, Husted, L. B., additional, Carstens, M., additional, Stenkjær, L., additional, Sørensen, L., additional, Pedersen, S. B., additional, and Langdahl, B. L., additional
- Published
- 2011
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138. Association analyses of 47,500 individuals identifies six fracture loci and 82 BMD loci clustering in biological pathways that regulate osteoblast and osteoclast activity
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Estrada, K., primary, Evangelou, E., additional, Hsu, Y.-H., additional, Styrkarsdottir, U., additional, Liu, C.-T., additional, Moayyeri, A., additional, Kaptoge, S., additional, Duncan, E., additional, Amin, N., additional, Kiel, D., additional, Karasik, D., additional, Albagha, O.M., additional, Brown, M., additional, Spector, T.D., additional, Zillikens, M.C., additional, Ohlsson, C., additional, Thorleifsson, G., additional, Reeve, J., additional, Vandenput, L., additional, Pettersson, U., additional, O'Neill, T., additional, Riancho, J.A., additional, ljunggren, O., additional, Rousseau, F., additional, Leslie, W.D., additional, Obermayer-Pietsch, B., additional, Alonso, N., additional, Langdahl, B., additional, Nogués, X., additional, Prince, R., additional, Lips, P., additional, Cheng, S., additional, Marc, J., additional, Kollia, P., additional, Brandi, M.L., additional, Hocking, L., additional, Khusnutdina, E., additional, Cooper, C., additional, Lehtimäki, T., additional, Jackson, R., additional, Koh, J.-M., additional, Minster, R.L., additional, Yerges-Armstrong, L., additional, Richards, B., additional, Glazer, N., additional, Kung, A., additional, Koller, D., additional, Evans, D., additional, Ioannidis, J., additional, Ralston, S.H., additional, Uitterlinden, A.G., additional, and Rivadeneira, F., additional
- Published
- 2011
- Full Text
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139. Periarticular and generalised bone loss in patients with early rheumatoid arthritis (ERA). Influence of alendronate (AL) and glucocorticoid treatment, and disease activity
- Author
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David, T.W.J., primary, Hansen, M.S., additional, Hørslev-Petersen, K., additional, Hyldstrup, L., additional, Abrahamsen, B., additional, Langdahl, B., additional, Zerahn, B., additional, Pødenphant, J., additional, Stengaard-Pedersen, K., additional, Junker, P., additional, Østergaard, M., additional, Lottenburger, T., additional, Ellingsen, T., additional, Smedegaard Andersen, L., additional, Hansen, I., additional, Skjødt, H., additional, Pedersen, J.K., additional, Lauridsen, U.B., additional, Svendsen, A., additional, Tarp, U., additional, Hansen, G., additional, Lindegaard, H., additional, Carvalho, A., additional, and Hetland, M., additional
- Published
- 2011
- Full Text
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140. VDR polymorphisms do not affect PTH response to vitamin D levels
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Rejnmark, L., primary, Harsløf, T., additional, Husted, L., additional, Jensen, J.E.B., additional, Mosekilde, L., additional, and Langdahl, B., additional
- Published
- 2011
- Full Text
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141. Hip structure analysis in patients with osteogenesis imperfecta compared with age and sex matched healthy controls
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Folkestad, L., primary, Hansen, S., additional, Ejersted, C., additional, Hald, J.D., additional, Langdahl, B., additional, Gram, J., additional, Abrahamsen, B., additional, and Brixen, K., additional
- Published
- 2011
- Full Text
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142. Four-year results of a phase 2 study of the cathepsin K inhibitor odanacatib in postmenopausal women with low bone mineral density: Effects on bone mineral density and bone turnover markers
- Author
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Resch, H., primary, Binkley, N., additional, Bone, H., additional, Eisman, J., additional, Hosking, D., additional, Langdahl, B., additional, McClung, M., additional, Reid, I., additional, Portales, J. Rodriguez, additional, Petrovic, R., additional, Rosenberg, E., additional, DaSilva, C., additional, Santora, A., additional, and Lombardi, A., additional
- Published
- 2011
- Full Text
- View/download PDF
143. Fracture rate and back pain during and after discontinuation of teriparatide: 36-month data from the European Forsteo Observational Study (EFOS)
- Author
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Fahrleitner-Pammer, A., primary, Langdahl, B. L., additional, Marin, F., additional, Jakob, F., additional, Karras, D., additional, Barrett, A., additional, Ljunggren, Ö., additional, Walsh, J. B., additional, Rajzbaum, G., additional, Barker, C., additional, and Lems, W. F., additional
- Published
- 2010
- Full Text
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144. Polymorphisms of the peroxisome proliferator-activated receptor γ (PPARγ) gene are associated with osteoporosis
- Author
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Harsløf, T., primary, Tofteng, C. L., additional, Husted, L. B., additional, Nyegaard, M., additional, Børglum, A., additional, Carstens, M., additional, Stenkjær, L., additional, Brixen, K., additional, Eiken, P., additional, Jensen, J-E B., additional, Mosekilde, L., additional, Rejnmark, L., additional, and Langdahl, B. L., additional
- Published
- 2010
- Full Text
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145. Polymorphisms in the ALOX12 gene and osteoporosis
- Author
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Harsløf, T., primary, Husted, L. B., additional, Nyegaard, M., additional, Carstens, M., additional, Stenkjær, L., additional, Brixen, K., additional, Eiken, P., additional, Jensen, J-E. B., additional, Børglum, A. D., additional, Mosekilde, L., additional, Rejnmark, L., additional, and Langdahl, B. L., additional
- Published
- 2010
- Full Text
- View/download PDF
146. Effects of COLIA1 polymorphisms and haplotypes on perimenopausal bone mass, postmenopausal bone loss and fracture risk
- Author
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González-Bofill, N., primary, Husted, L. B., additional, Harsløf, T., additional, Tofteng, C. L., additional, Abrahamsen, B., additional, Eiken, P., additional, Vestergaard, P., additional, and Langdahl, B. L., additional
- Published
- 2010
- Full Text
- View/download PDF
147. Fracture incidence, quality of life and back pain in women with osteoporosis pretreated with bisphosphonates: 36 month results from the European forsteo observational study (EFOS)
- Author
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Jakob, F., primary, Langdahl, B., additional, Ljunggren, Ö., additional, Barrett, A., additional, Karras, D., additional, Walsh, B., additional, Fahrleitner-Pammer, A., additional, Rajzbaum, G., additional, Barker, C., additional, Lems, W., additional, and Marin, F., additional
- Published
- 2010
- Full Text
- View/download PDF
148. Haplotypes of Promoter and Intron 1 Polymorphisms in the COLIA1 Gene Are Associated with Increased Risk of Osteoporosis
- Author
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Husted, L. B., primary, Harsløf, T., additional, Gonzalez-Bofill, N., additional, Schmitz, A., additional, Carstens, M., additional, Stenkjær, L., additional, and Langdahl, B. L., additional
- Published
- 2008
- Full Text
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149. Clinical importance of accuracy-error and reference values in DXA – a nationwide study
- Author
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Hamborg-Petersen, Ellen, primary, Hanmann, E., additional, Tøt, B., additional, Abrahamsen, B., additional, Langdahl, B., additional, Hermann, A.P., additional, Gotfredsen, A., additional, Beck-Jensen, J., additional, and Brixen, K., additional
- Published
- 2007
- Full Text
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150. Cross-calibration of dual-energy X-ray densitometers for a large, multi-center genetic study of osteoporosis
- Author
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Reid, D. M., primary, Mackay, I., additional, Wilkinson, S., additional, Miller, C., additional, Schuette, D. G., additional, Compston, J., additional, Cooper, C., additional, Duncan, E., additional, Galwey, N., additional, Keen, R., additional, Langdahl, B., additional, McLellan, A., additional, Pols, H., additional, Uitterlinden, A., additional, O’Riordan, J., additional, Wass, J. A. H., additional, Ralston, S. H., additional, and Bennett, S. T., additional
- Published
- 2005
- Full Text
- View/download PDF
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