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102. Dupilumab sustains long-term OCS reduction in OCS-dependent asthma patients

Author

Sher, Lawrence, primary, Wechsler, Michael E., additional, Rabe, Klaus F., additional, Maspero, Jorge F., additional, Daizadeh, Nadia, additional, Mao, Xuezhou, additional, Ortiz, Benjamin, additional, Mannent, Leda P., additional, Laws, Elizabeth, additional, Ruddy, Marcella, additional, Pandit-Abid, Nami, additional, Lederer, David J., additional, and Hardin, Megan, additional

Published
2021
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103. Dupilumab efficacy in children with uncontrolled, moderate-to-severe asthma with and without an allergic phenotype

Author

Papadopoulos, Nikolaos, primary, Szefler, Stanley J., additional, Bacharier, Leonard B., additional, Maspero, Jorge F., additional, Domingo, Christian, additional, Daizadeh, Nadia, additional, Lederer, David J., additional, Hardin, Megan, additional, Jacob-Nara, Juby A., additional, Deniz, Yamo, additional, Gall, Rebecca, additional, Ortiz, Benjamin, additional, Djandji, Michel, additional, and Rowe, Paul, additional

Published
2021
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111. Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19 : a meta-analysis

Author

The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, [missing], Domingo, Pere, Mur, Isabel, Mateo, Gracia María, Gutierrez, Maria del Mar, Pomar, Virginia, de Benito, Natividad, Corbacho, Noemí, Herrera, Silvia, Millan, Lucia, Muñoz, Jessica, Malouf, Jorge, Molas, Maria Ema, Asensi, Victor, Horcajada, Juan Pablo, Estrada, Vicente, Gutierrez, Felix, Torres, Ferran, Perez-Molina, Jose A, Fortun, Jesús, Villar, Luisa M, Hohenthal, Ulla, Marttila, Harri, Vuorinen, Tytti, Nordberg, Marika, Valtonen, Mika, Frigault, Matthew J, Mansour, Michael K, Patel, Naomi J, Fernandes, Ana, Harvey, Liam, Foulkes, Andrea S, Healy, Brian C, Shah, Ruta, Bensaci, Ana Maria, Woolley, Ann E., Nikiforow, Sarah, Lin, Nina, Sagar, Manish, Shrager, Harry, Huckins, David S., Axelrod, Matthew, Pincus, Michael D, Fleisher, Jorge, Lampa, Jon, Nowak, Piotr, Vesterbacka, Jan C., Rasmuson, Johan, Skorup, Paul, Janols, Helena, Niward, Katarina F, Chatzidionysiou, Katerina, Asgeirsson, Hilmir, Parke, Åsa, Blennow, Ola, Svensson, Anna-Karin, Aleman, Soo, Sönnerborg, Anders, Henter, Jan-Inge, Horne, Anna Carin, Al-Beidh, Farah, Angus, Derek, Annane, Djillali, Arabi, Yaseen, Beane, Abigail, Berry, Scott, Bhimani, Zahra, Bonten, Marc, Bradbury, Charlotte, Brunkhorst, Frank, Buxton, Meredith, Cheng, Allen, Cove, Matt, De Jong, Menno, Derde, Lennie, Estcourt, Lise, Goossens, Herman, Gordon, Anthony, Green, Cameron, Haniffa, Rashan, Ichihara, Nao, Lamontagne, Francois, Lawler, Patrick, Litton, Ed, Marshall, John, McArthur, Colin, McAuley, Daniel, McGuinness, Shay, McVerry, Bryan, Montgommery, Stephanie, Mouncey, Paul, Murthy, Srinivas, Nichol, Alistair, Parke, Rachael, Parker, Jane, Reyes, Felipe, Rowan, Kathryn, Saito, Hiroki, Santos, Marlene, Seymour, Chris, Shankar-Hari, Manu, Turgeon, Alexis, Turner, Anne, van Bentum-Puijk, Wilma, van de Veerdonk, Frank, Webb, Steve, Zarychanski, Ryan, Baillie, J Kenneth, Beasley, Richard, Cooper, Nichola, Fowler, Robert, Galea, James, Hills, Thomas, King, Andrew, Morpeth, Susan, Netea, Mihai, Ogungbenro, Kayode, Pettila, Ville, Tong, Steve, Uyeki, Tim, Youngstein, Taryn, Higgins, Alisa, Lorenzi, Elizabeth, Berry, Lindsay, Salama, Carlos, Rosas, Ivan O., Ruiz-Antorán, Belén, Muñez Rubio, Elena, Ramos Martínez, Antonio, Campos Esteban, José, Avendaño Solá, Cristina, Pizov, Reuven, Sanz Sanz, Jesus, Abad-Santos, Francisco, Bautista-Hernández, Azucena, García-Fraile, Lucio, Barrios, Ana, Gutiérrez Liarte, Ángela, Alonso Pérez, Tamara, Rodríguez-García, Sebastian C, Mejía-Abril, Gina, Prieto, Jose Carlos, Leon, Rafael, VEIGA, VIVIANE C., SCHEINBERG, PHILLIP, FARIAS, DANIELLE L.C., PRATS, JOÃO G., CAVALCANTI, ALEXANDRE B., MACHADO, FLAVIA R., ROSA, REGIS G., BERWANGER, OTÁVIO, AZEVEDO, LUCIANO C.P., LOPES, RENATO D., DOURADO, LETICIA K., CASTRO, CLAUDIO G., ZAMPIERI, FERNANDO G., AVEZUM, ALVARO, LISBOA, THIAGO C., ROJAS, SALOMÓN S.O., COELHO, JULIANA C., LEITE, RODRIGO T., CARVALHO, JULIO CESAR, ANDRADE, LUIS E.C., SANDES, ALEX R., PINTÃO, MARIA CAROLINA T., SANTOS, SUELI V., ALMEIDA, THIAGO M.L., COSTA, ANDRÉ N., GEBARA, OTAVIO C.E., FREITAS, FLAVIO G.R., PACHECO, EDUARDO S., MACHADO, DAVID J.B., MARTIN, JOSIANE, CONCEIÇÃO, FABIO G., SIQUEIRA, SUELLEN R.R., DAMIANI, LUCAS P., ISHIHARA, LUCIANA M., SCHNEIDER, DANIEL, DE SOUZA, DENISE, Hermine, Olivier, Mariette, Xavier, Tharaux, Pierre Louis, Resche Rigon, Matthieu, Porcher, Raphael, Ravaud, Philippe, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Pourchet-Martinez, Valérie, Schlemmer, Frédéric, Tibi, Annick, Yazdanpanah, Yazdan, Dougados, Maxime, Bureau, Serge, Horby, Peter W, Landray, Martin J, Baillie, Kenneth J, Buch, Maya H, Chappell, Lucy C, Day, Jeremy N, Faust, Saul N, Haynes, Richard, Jaki, Thomas, Jeffery, Katie, Juszczak, Edmund, Lim, Wei Shen, Mafham, Marion, Montgomery, Alan, Mumford, Andrew, Thwaites, Guy, Kamarulzaman, Adeeba, Syed Omar, Sharifah Faridah, Ponnampalavanar, Sasheela, Raja Azwa, Raja Iskandar Syah, Wong, Pui Li, Kukreja, Anjanna, Ong, Hang Cheng, Sulaiman, Helmi, Basri, Sazali, Ng, Rong Xiang, Megat Johari, Bushra, Rajasuriar, Reena, Chong, Meng Li, Neelamegam, Malinee, Syed Mansor, Syed Mukhtar, Zulhaimi, Nurul Syuhada, Lee, Cheng Siang, Altice, Frederick, Price, Christina, Malinis, Maricar, Hasan, Mohd Shahnaz, Wong, Chee Kuan, Chidambaram, Suresh, Misnan, Nor Arisah, Mohd Thabit, Alif Adlan, Sim, Benedict, Bidin, Farah Nadiah, Mohd Abd Rahim, Mohd Abd Hafiz, Saravanamuttu, Sujana, Tuang, Wei Xuan, Mohamed Gani, Yasmin, Thangavelu, Suvintheran, Tay, Kim Heng, Ibrahim, Nur Munirah, Halid, Luqman Alhakim, Tan, Kok Tong, Mukri, Mohd Noor Azreet, Arip, Masita, Koh, Hui Moon, Syed Badaruddin, Syarifah Nurul Ain, Raja Sureja, Letchumi, Chun, Geok Ying, TORRE-CISNEROS, JULIAN, MERCHANTE, NICOLAS, LEON, RAFAEL, CARCEL, SHEILA, GARRIDO, JOSE CARLOS, Galun, Eitan, Soriano, Alex, Martínez, José Antonio, Castán, Clara, Paredes, Roger, Dalmau, David, Carbonell, Cristina, Espinosa, Gerard, Castro, Pedro, Muñóz, José, Almuedo, Alex, Prieto, Sergio, Pacheco, Iván, Ratain, Mark, Pisano, Jennifer, Strek, Mary, Adegunsoye, Ayodeji, Karrison, Theodore, Declercq, Jozefien, Van Damme, Karel, De Leeuw, Elisabeth, Bosteels, Cedric, Maes, Bastiaan, Vale, Claire L., Godolphin, Peter J., Fisher, David, Higgins, Julian P. T., Spiga, Francesca, Savovic, Jelena, Tierney, Jayne, Baron, Gabriel, Benbenishty, Julie S., Berry, Lindsay R., Broman, Niklas, Cavalcanti, Alexandre Biasi, Colman, Roos, De Buyser, Stefanie, Derde, Lennie P. G., Omar, Sharifah Faridah, Fernandez-Cruz, Ana, Feuth, Thijs, Garcia, Felipe, Garcia-Vicuna, Rosario, Gonzalez-Alvaro, Isidoro, Gordon, Anthony C., Horby, Peter W., Horick, Nora K., Kumar, Kuldeep, Lambrecht, Bart, Landray, Martin J., Leal, Lorna, Lederer, David J., Merchante, Nicolas, Mohan, Shalini V., Nivens, Michael C., Oksi, Jarmo, Perez-Molina, Jose A., Postma, Simone, Ramanan, Athimalaipet V., Reid, Pankti D., Rutgers, Abraham, Sancho-Lopez, Aranzazu, Seto, Todd B., Sivapalasingam, Sumathi, Soin, Arvinder Singh, Staplin, Natalie, Stone, John H., Strohbehn, Garth W., Sunden-Cullberg, Jonas, Torre-Cisneros, Julian, Tsai, Larry W., van Hoogstraten, Hubert, van Meerten, Tom, Veiga, Viviane Cordeiro, Westerweel, Peter E., Diaz, Janet V., Marshall, John C., Sterne, Jonathan A. C., Translational Immunology Groningen (TRIGR), Stem Cell Aging Leukemia and Lymphoma (SALL), World Health Organization, and Group, WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working

Subjects
Male, medicine.medical_specialty, Randomization, Secondary infection, Placebo, Antibodies, Monoclonal, Humanized, Internal medicine, Cause of Death, Medicine and Health Sciences, Medicine, Humans, Prospective Studies, Prospective cohort study, Glucocorticoids, METAANALYSIS, Cause of death, Aged, Randomized Controlled Trials as Topic, business.industry, Coinfection, Interleukin-6, COVID-19, Odds ratio, General Medicine, Middle Aged, Respiration, Artificial, COVID-19 Drug Treatment, Clinical trial, Hospitalization, Meta-analysis, Disease Progression, Drug Therapy, Combination, Female, business
Abstract

[Importance] Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm., [Objective] To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes., [Data Sources] Trials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts., [Study Selection] Eligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria., [Data Extraction and Synthesis] In this prospective meta-analysis, risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I2 statistic. The primary analysis was an inverse variance–weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality., [Main Outcomes and Measures] The primary outcome measure was all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days., [Results] A total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P = .003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P, [Conclusions and Relevance] In this prospective meta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality., [Trial Registration] PROSPERO Identifier: CRD42021230155., Funding for administrative and communications support was provided by the World Health Organization.

Published
2021

117. A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

Author

King, Talmadge E., Jr., Bradford, Williamson Z., Castro-Bernardini, Socorro, Fagan, Elizabeth A., Glaspole, Ian, Glassberg, Marilyn K., Gorina, Eduard, Hopkins, Peter M., Kardatzke, David, Lancaster, Lisa, Lederer, David J., Nathan, Steven D., Pereira, Carlos A., Sahn, Steven A., Sussman, Robert, Swigris, Jeffrey J., and Noble, Paul W.

Published
2014
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119. Control of Confounding and Reporting of Results in Causal Inference Studies. Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals

Author

Lederer, David J, Bell, Scott C, Branson, Richard D, Chalmers, James D, Marshall, Rachel, Maslove, David M, Ost, David E, et al, Akdis, Cezmi A, University of Zurich, and Lederer, David J

Subjects
Pulmonary and Respiratory Medicine, 10183 Swiss Institute of Allergy and Asthma Research, 2740 Pulmonary and Respiratory Medicine, 610 Medicine & health
Published
2019

120. Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease

Author

Natalini, Jake G., primary, Diamond, Joshua M., additional, Porteous, Mary K., additional, Lederer, David J., additional, Wille, Keith M., additional, Weinacker, Ann B., additional, Orens, Jonathan B., additional, Shah, Pali D., additional, Lama, Vibha N., additional, McDyer, John F., additional, Snyder, Laurie D., additional, Hage, Chadi A., additional, Singer, Jonathan P., additional, Ware, Lorraine B., additional, Cantu, Edward, additional, Oyster, Michelle, additional, Kalman, Laurel, additional, Christie, Jason D., additional, Kawut, Steven M., additional, and Bernstein, Elana J., additional

Published
2021
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121. Assessing predictors of rheumatoid arthritis-associated interstitial lung disease using quantitative lung densitometry.

Author

Alevizos, Michail K, Danoff, Sonye K, Pappas, Dimitrios A, Lederer, David J, Johnson, Cheilonda, Hoffman, Eric A, Bernstein, Elana J, Bathon, Joan M, and Giles, Jon T

Subjects
RHEUMATOID arthritis diagnosis, STATISTICS, CONFIDENCE intervals, INTERSTITIAL lung diseases, QUANTITATIVE research, REGRESSION analysis, ALLELES, SEX distribution, DENSITOMETRY, RHEUMATOID arthritis, DESCRIPTIVE statistics, DATA analysis, SMOKING, BODY mass index, RECEIVER operating characteristic curves, PULMONARY fibrosis, DATA analysis software, DISEASE complications
Abstract

Objective To assess predictors of subclinical RA-associated interstitial lung disease (RA-ILD) using quantitative lung densitometry (qLD). Methods RA patients underwent multi-detector row CT scanning at baseline and after an average of 39 months. Scans were analysed with qLD for the percentage of lung parenchyma with high attenuation areas (%HAA: the percentage of voxels of –600 to –250 Hounsfield units). Additionally, a pulmonary radiologist calculated an expert radiologist scoring (ERS) for RA-ILD features. Generalized linear models were used to identify indicators of baseline %HAA and predictors of %HAA change. Results Baseline %HAA was assessed in 193 RA patients and 106 had repeat qLD assessment. %HAA was correlated with ERS (Spearman's rho = 0.261; P  < 0.001). Significant indicators of high baseline %HAA (>10% of lung parenchyma with high attenuation) included female sex, higher pack-years of smoking, higher BMI and anti-CCP ≥200 units, collectively contributing an area under the receiver operator curve of 0.88 (95% CI 0.81, 0.95). Predictors of %HAA increase, occurring in 49% with repeat qLD, included higher baseline %HAA, presence of mucin 5B (MUC5B) minor allele and absence of HLA-DRB1 shared epitope (area under the receiver operator curve = 0.69; 95% CI 0.58, 0.79). The association of the MUC5B minor allele with %HAA change was higher among men and those with higher cumulative smoking. Within the group with increased %HAA, anti-CCP level was significantly associated with a greater increase in %HAA. Conclusions %HAA, assessed with qLD, was linked to several known risk factors for RA-ILD and may represent a more quantitative method to identify RA-ILD and track progression than expert radiologist interpretation. [ABSTRACT FROM AUTHOR]

Published
2022
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122. Associations of Serum Adipokines With Subclinical Interstitial Lung Disease Among Community-Dwelling Adults: The Multi-Ethnic Study of Atherosclerosis (MESA)

Author

Kim, John S., Anderson, Michaela R., Podolanczuk, Anna J., Kawut, Steven M., Allison, Matthew A., Raghu, Ganesh, Hinckley-Stuckovsky, Karen, Hoffman, Eric A., Tracy, Russell P., Barr, R. Graham, Lederer, David J., and Giles, Jon T.

Subjects
Lung Diseases, Leptin, Male, Vital Capacity, Clinical Sciences, Respiratory System, Body Mass Index, Cohort Studies, Adipokines, Clinical Research, Humans, 2.1 Biological and endogenous factors, Resistin, Obesity, Aetiology, Lung, Tomography, Original Research, Aged, interstitial lung disease, adipokine, Prevention, Smoking, nutritional and metabolic diseases, respiratory system, Middle Aged, Atherosclerosis, X-Ray Computed, Asymptomatic Diseases, Female, epidemiology, Adiponectin, Independent Living, chest imaging, Lung Diseases, Interstitial, Tomography, X-Ray Computed, Interstitial, hormones, hormone substitutes, and hormone antagonists
Abstract

BackgroundAdipokines have inflammatory and fibrotic properties that may be critical in interstitial lung disease (ILD). We examined associations of serum adipokine levels with CT imaging-based measures of subclinical ILD and lung function among community-dwelling adults.MethodsA subset of the original Multi-Ethnic Study of Atherosclerosis cohort (n= 1,968) had adiponectin, leptin, and resistin measured during follow-up visits (2002-2005). We used regression models to examine associations of adiponectin, leptin, and resistin levels with (1) high-attenuation areas (HAAs) from CT scans (2004-2005, n= 1,144), (2) interstitial lung abnormalities (ILAs) from CT scans (2010-2012, n= 872), and (3) FVC from spirometry (2004-2006, n= 1,446). We used -(1/HAA2), which we denoted with H, to model HAA as our outcome to meet model assumptions.ResultsHigher adiponectin was associated with lower HAA on CT imaging among adults with a BMI≥ 25kg/m2 (P for BMI interaction= .07). Leptin was more strongly associated with ILA among never smokers compared with ever smokers (P for smoking interaction= .004). For every 1-SD increment of log-transformed leptin, the percent predicted FVC was 3.8%lower (95%CI,-5.0 to-2.5). Higher serum resistin levels were associated with greater HAA on CT in a fully adjusted model. For every 1-SD increment of log-transformed resistin there was an increase in H of 14.8 (95%CI, 3.4-26.3).ConclusionsHigher adiponectin levels were associated with lower HAA on CT imaging among adults with a higher BMI. Higher leptin and resistin levels were associated with lower FVC and greater HAA, respectively.

Published
2020

123. Diagnosis of Hypersensitivity Pneumonitis in Adults: An Official ATS/JRS/ALAT Clinical Practice Guideline

Author

Raghu, Ganesh, Document, Society, Remy-Jardin, Martine, Ryerson, Christopher J, Myers, Jeffrey L, Kreuter, Michael, Vasakova, Martina, Bargagli, Elena, Chung, Jonathan H, Collins, Bridget F, Bendstrup, Elisabeth, Chami, Hassan A, Chua, Abigail T, Corte, Tamera J, Dalphin, Jean-Charles, Danoff, Sonye K, Diaz-Mendoza, Javier, Duggal, Abhijit, Egashira, Ryoko, Ewing, Thomas, Gulati, Mridu, Inoue, Yoshikazu, Jenkins, Alex R, Johannson, Kerri A, Johkoh, Takeshi, Tamae-Kakazu, Maximiliano, Kitaichi, Masanori, Knight, Shandra L, Koschel, Dirk, Lederer, David J, Mageto, Yolanda, Maier, Lisa A, Matiz, Carlos, Morell, Ferran, Nicholson, Andrew G, Patolia, Setu, Pereira, Carlos A, Renzoni, Elisabetta A, Salisbury, Margaret L, Selman, Moises, Walsh, Simon L F, Wuyts, Wim A, and Wilson, Kevin C

Subjects
Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, Biopsy, Nonfibrotic hypersensitivity pneumonitis, Interstitial lung disease, Lung biopsy, Critical Care and Intensive Care Medicine, Cryosurgery, Pulmonary fibrosis, Surveys and Questionnaires, Bronchoscopy, Medicine, Humans, Serologic Tests, Fibrotic hypersensitivity pneumonitis, Lymphocytes, Intensive care medicine, Medical History Taking, Lung, American Thoracic Society Documents, interstitial lung disease, Inhalation Exposure, medicine.diagnostic_test, pulmonary fibrosis, business.industry, fibrotic hypersensitivity pneumonitis, nonfibrotic hypersensitivity pneumonitis, Guideline, medicine.disease, Systematic review, Bronchoalveolar lavage, medicine.anatomical_structure, Immunoglobulin G, hypersensitivity pneumonitis, business, Bronchoalveolar Lavage Fluid, Hypersensitivity pneumonitis, Alveolitis, Extrinsic Allergic
Abstract

Background: This guideline addresses the diagnosis of hypersensitivity pneumonitis (HP). It represents a collaborative effort among the American Thoracic Society, Japanese Respiratory Society, and Asociación Latinoamericana del Tórax.Methods: Systematic reviews were performed for six questions. The evidence was discussed, and then recommendations were formulated by a multidisciplinary committee of experts in the field of interstitial lung disease and HP using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach.Results: The guideline committee defined HP, and clinical, radiographic, and pathological features were described. HP was classified into nonfibrotic and fibrotic phenotypes. There was limited evidence that was directly applicable to all questions. The need for a thorough history and a validated questionnaire to identify potential exposures was agreed on. Serum IgG testing against potential antigens associated with HP was suggested to identify potential exposures. For patients with nonfibrotic HP, a recommendation was made in favor of obtaining bronchoalveolar lavage (BAL) fluid for lymphocyte cellular analysis, and suggestions for transbronchial lung biopsy and surgical lung biopsy were also made. For patients with fibrotic HP, suggestions were made in favor of obtaining BAL for lymphocyte cellular analysis, transbronchial lung cryobiopsy, and surgical lung biopsy. Diagnostic criteria were established, and a diagnostic algorithm was created by expert consensus. Knowledge gaps were identified as future research directions.Conclusions: The guideline committee developed a systematic approach to the diagnosis of HP. The approach should be reevaluated as new evidence accumulates. ispartof: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE vol:202 issue:3 pages:E36-E69 ispartof: location:United States status: published

Published
2020

125. Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals

Author

Leisman, D, Harhay, M, Lederer, D, Abramson, M, Adjei, A, Bakker, J, Ballas, Z, Barreiro, E, Bell, S, Bellomo, R, Bernstein, J, Branson, R, Brusasco, V, Chalmers, J, Chokroverty, S, Citerio, G, Collop, N, Cooke, C, Crapo, J, Donaldson, G, Fitzgerald, D, Grainger, E, Hale, L, Herth, F, Kochanek, P, Marks, G, Moorman, J, Ost, D, Schatz, M, Sheikh, A, Smyth, A, Stewart, I, Stewart, P, Swenson, E, Szymusiak, R, Teboul, J, Vincent, J, Wedzicha, J, Maslove, D, Leisman, Daniel E, Harhay, Michael O, Lederer, David J, Abramson, Michael, Adjei, Alex A, Bakker, Jan, Ballas, Zuhair K, Barreiro, Esther, Bell, Scott C, Bellomo, Rinaldo, Bernstein, Jonathan A, Branson, Richard D, Brusasco, Vito, Chalmers, James D, Chokroverty, Sudhansu, Citerio, Giuseppe, Collop, Nancy A, Cooke, Colin R, Crapo, James D, Donaldson, Gavin, Fitzgerald, Dominic A, Grainger, Emma, Hale, Lauren, Herth, Felix J, Kochanek, Patrick M, Marks, Guy, Moorman, J Randall, Ost, David E, Schatz, Michael, Sheikh, Aziz, Smyth, Alan R, Stewart, Iain, Stewart, Paul W, Swenson, Erik R, Szymusiak, Ronald, Teboul, Jean-Louis, Vincent, Jean-Louis, Wedzicha, Jadwiga A, Maslove, David M, Leisman, D, Harhay, M, Lederer, D, Abramson, M, Adjei, A, Bakker, J, Ballas, Z, Barreiro, E, Bell, S, Bellomo, R, Bernstein, J, Branson, R, Brusasco, V, Chalmers, J, Chokroverty, S, Citerio, G, Collop, N, Cooke, C, Crapo, J, Donaldson, G, Fitzgerald, D, Grainger, E, Hale, L, Herth, F, Kochanek, P, Marks, G, Moorman, J, Ost, D, Schatz, M, Sheikh, A, Smyth, A, Stewart, I, Stewart, P, Swenson, E, Szymusiak, R, Teboul, J, Vincent, J, Wedzicha, J, Maslove, D, Leisman, Daniel E, Harhay, Michael O, Lederer, David J, Abramson, Michael, Adjei, Alex A, Bakker, Jan, Ballas, Zuhair K, Barreiro, Esther, Bell, Scott C, Bellomo, Rinaldo, Bernstein, Jonathan A, Branson, Richard D, Brusasco, Vito, Chalmers, James D, Chokroverty, Sudhansu, Citerio, Giuseppe, Collop, Nancy A, Cooke, Colin R, Crapo, James D, Donaldson, Gavin, Fitzgerald, Dominic A, Grainger, Emma, Hale, Lauren, Herth, Felix J, Kochanek, Patrick M, Marks, Guy, Moorman, J Randall, Ost, David E, Schatz, Michael, Sheikh, Aziz, Smyth, Alan R, Stewart, Iain, Stewart, Paul W, Swenson, Erik R, Szymusiak, Ronald, Teboul, Jean-Louis, Vincent, Jean-Louis, Wedzicha, Jadwiga A, and Maslove, David M

Abstract

Prediction models aim to use available data to predict a health state or outcome that has not yet been observed. Prediction is primarily relevant to clinical practice, but is also used in research, and administration. While prediction modeling involves estimating the relationship between patient factors and outcomes, it is distinct from casual inference. Prediction modeling thus requires unique considerations for development, validation, and updating. This document represents an effort from editors at 31 respiratory, sleep, and critical care medicine journals to consolidate contemporary best practices and recommendations related to prediction study design, conduct, and reporting. Herein, we address issues commonly encountered in submissions to our various journals. Key topics include considerations for selecting predictor variables, operationalizing variables, dealing with missing data, the importance of appropriate validation, model performance measures and their interpretation, and good reporting practices. Supplemental discussion covers emerging topics such as model fairness, competing risks, pitfalls of "modifiable risk factors", measurement error, and risk for bias. This guidance is not meant to be overly prescriptive; we acknowledge that every study is different, and no set of rules will fit all cases. Additional best practices can be found in the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) guidelines, to which we refer readers for further details.

Published
2020

126. Baseline SARS-CoV-2 Viral Load Is Associated with Disease Severity and Clinical Outcomes in Hospitalised Patients with COVID-19: Post-Hoc Analyses of a Phase 2/3 Multicentre Trial

Author

Boyapati, Anita, primary, Wipperman, Matthew F., additional, Ehmann, Peter J., additional, Hamon, Sara, additional, Lederer, David J., additional, Waldron, Alpana, additional, Flanagan, John J., additional, Karayusuf, Elif, additional, Bhore, Rafia, additional, Nivens, Michael C., additional, Hamilton, Jennifer D., additional, Sumner, Giane, additional, and Sivapalasingam, Sumathi, additional

Published
2021
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129. Treatment of Idiopathic Pulmonary Fibrosis With Ambrisentan: A Parallel, Randomized Trial

Author

Raghu, Ganesh, Behr, Juergen, Brown, Kevin K., Egan, Jim J., Kawut, Steven M., Flaherty, Kevin R., Martinez, Fernando J., Nathan, Steven D., Wells, Athol U., Collard, Harold R., Costabel, Ulrich, Richeldi, Luca, de Andrade, Joao, Khalil, Nasreen, Morrison, Lake D., Lederer, David J., Shao, Lixin, Li, Xiaoming, Pedersen, Patty S., Montgomery, A. Bruce, Chien, Jason W., and OʼRiordan, Thomas G.

Published
2013

140. Home Oxygen Therapy for Adults with Chronic Lung Disease. An Official American Thoracic Society Clinical Practice Guideline

Author

Jacobs, Susan S., primary, Krishnan, Jerry A., additional, Lederer, David J., additional, Ghazipura, Marya, additional, Hossain, Tanzib, additional, Tan, Ai-Yui M., additional, Carlin, Brian, additional, Drummond, M. Bradley, additional, Ekström, Magnus, additional, Garvey, Chris, additional, Graney, Bridget A., additional, Jackson, Beverly, additional, Kallstrom, Thomas, additional, Knight, Shandra L., additional, Lindell, Kathleen, additional, Prieto-Centurion, Valentin, additional, Renzoni, Elisabetta A., additional, Ryerson, Christopher J., additional, Schneidman, Ann, additional, Swigris, Jeffrey, additional, Upson, Dona, additional, and Holland, Anne E., additional

Published
2020
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141. Thoracic Visceral Adipose Tissue Area and Pulmonary Hypertension in Lung Transplant Candidates. The Lung Transplant Body Composition Study

Author

Al-Naamani, Nadine, primary, Pan, Hao-Min, additional, Anderson, Michaela R., additional, Torigian, Drew A., additional, Tong, Yubing, additional, Oyster, Michelle, additional, Porteous, Mary K., additional, Palmer, Scott, additional, Arcasoy, Selim M., additional, Diamond, Joshua M., additional, Udupa, Jayaram K., additional, Christie, Jason D., additional, Lederer, David J., additional, and Kawut, Steven M., additional

Published
2020
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142. Associations of ω-3 Fatty Acids With Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults

Author

Kim, John S, primary, Steffen, Brian T, additional, Podolanczuk, Anna J, additional, Kawut, Steven M, additional, Noth, Imre, additional, Raghu, Ganesh, additional, Michos, Erin D, additional, Hoffman, Eric A, additional, Axelsson, Gisli Thor, additional, Gudmundsson, Gunnar, additional, Gudnason, Vilmundur, additional, Gudmundsson, Elias F, additional, Murphy, Rachel A, additional, Dupuis, Josée, additional, Xu, Hanfei, additional, Vasan, Ramachandran S, additional, O’Connor, George T, additional, Harris, William S, additional, Hunninghake, Gary M, additional, Barr, R Graham, additional, Tsai, Michael Y, additional, and Lederer, David J, additional

Published
2020
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143. Diagnosis of Hypersensitivity Pneumonitis in Adults: An Official ATS/JRS/ALAT Clinical Practice Guideline

Author

Raghu, Ganesh, primary, Remy-Jardin, Martine, additional, Ryerson, Christopher J., additional, Myers, Jeffrey L., additional, Kreuter, Michael, additional, Vasakova, Martina, additional, Bargagli, Elena, additional, Chung, Jonathan H., additional, Collins, Bridget F., additional, Bendstrup, Elisabeth, additional, Chami, Hassan A., additional, Chua, Abigail T., additional, Corte, Tamera J., additional, Dalphin, Jean-Charles, additional, Danoff, Sonye K., additional, Diaz-Mendoza, Javier, additional, Duggal, Abhijit, additional, Egashira, Ryoko, additional, Ewing, Thomas, additional, Gulati, Mridu, additional, Inoue, Yoshikazu, additional, Jenkins, Alex R., additional, Johannson, Kerri A., additional, Johkoh, Takeshi, additional, Tamae-Kakazu, Maximiliano, additional, Kitaichi, Masanori, additional, Knight, Shandra L., additional, Koschel, Dirk, additional, Lederer, David J., additional, Mageto, Yolanda, additional, Maier, Lisa A., additional, Matiz, Carlos, additional, Morell, Ferran, additional, Nicholson, Andrew G., additional, Patolia, Setu, additional, Pereira, Carlos A., additional, Renzoni, Elisabetta A., additional, Salisbury, Margaret L., additional, Selman, Moises, additional, Walsh, Simon L. F., additional, Wuyts, Wim A., additional, and Wilson, Kevin C., additional

Published
2020
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144. Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis

Author

Allen, Richard J., primary, Guillen-Guio, Beatriz, additional, Oldham, Justin M., additional, Ma, Shwu-Fan, additional, Dressen, Amy, additional, Paynton, Megan L., additional, Kraven, Luke M., additional, Obeidat, Ma'en, additional, Li, Xuan, additional, Ng, Michael, additional, Braybrooke, Rebecca, additional, Molina-Molina, Maria, additional, Hobbs, Brian D., additional, Putman, Rachel K., additional, Sakornsakolpat, Phuwanat, additional, Booth, Helen L., additional, Fahy, William A., additional, Hart, Simon P., additional, Hill, Mike R., additional, Hirani, Nik, additional, Hubbard, Richard B., additional, McAnulty, Robin J., additional, Millar, Ann B., additional, Navaratnam, Vidyia, additional, Oballa, Eunice, additional, Parfrey, Helen, additional, Saini, Gauri, additional, Whyte, Moira K. B., additional, Zhang, Yingze, additional, Kaminski, Naftali, additional, Adegunsoye, Ayodeji, additional, Strek, Mary E., additional, Neighbors, Margaret, additional, Sheng, Xuting R., additional, Gudmundsson, Gunnar, additional, Gudnason, Vilmundur, additional, Hatabu, Hiroto, additional, Lederer, David J., additional, Manichaikul, Ani, additional, Newell, John D., additional, O’Connor, George T., additional, Ortega, Victor E., additional, Xu, Hanfei, additional, Fingerlin, Tasha E., additional, Bossé, Yohan, additional, Hao, Ke, additional, Joubert, Philippe, additional, Nickle, David C., additional, Sin, Don D., additional, Timens, Wim, additional, Furniss, Dominic, additional, Morris, Andrew P., additional, Zondervan, Krina T., additional, Hall, Ian P., additional, Sayers, Ian, additional, Tobin, Martin D., additional, Maher, Toby M., additional, Cho, Michael H., additional, Hunninghake, Gary M., additional, Schwartz, David A., additional, Yaspan, Brian L., additional, Molyneaux, Philip L., additional, Flores, Carlos, additional, Noth, Imre, additional, Jenkins, R. Gisli, additional, and Wain, Louise V., additional

Published
2020
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145. Reference values for high attenuation areas on chest CT in a healthy, never‐smoker, multi‐ethnic sample: The MESA study

Author

Easthausen, Imaani, primary, Podolanczuk, Anna, additional, Hoffman, Eric, additional, Kawut, Steven, additional, Oelsner, Elizabeth, additional, Kim, John S., additional, Raghu, Ganesh, additional, Stukovsky, Karen Hinckley, additional, Redline, Susan, additional, McClelland, Robyn L., additional, Barr, R Graham, additional, and Lederer, David J., additional

Published
2020
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146. Antinuclear antibodies and subclinical interstitial lung disease in community-dwelling adults: the MESA study

Author

Bernstein, Elana J., primary, Austin, John H.M., additional, Kawut, Steven M., additional, Raghu, Ganesh, additional, Hoffman, Eric A., additional, Newell, John D., additional, Watts, Jubal R., additional, Nath, P. Hrudaya, additional, Sonavane, Sushilkumar K., additional, Barr, R. Graham, additional, and Lederer, David J., additional

Published
2020
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148. Plasma Levels of Receptor for Advanced Glycation End Products, Blood Transfusion, and Risk of Primary Graft Dysfunction

Author

Christie, Jason D., Shah, Chirag V., Kawut, Steven M., Mangalmurti, Nilam, Lederer, David J., Sonett, Joshua R., Ahya, Vivek N., Palmer, Scott M., Wille, Keith, Lama, Vibha, Shah, Pali D., Shah, Ashish, Weinacker, Ann, Deutschman, Clifford S., Kohl, Benjamin A., Demissie, Ejigayehu, Bellamy, Scarlett, and Ware, Lorraine B.

Published
2009
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