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104. Adherence to a healthy lifestyle and all-cause and cause-specific mortality in Chinese adults: a 10-year prospective study of 0.5 million people.

Author

Zhu, Nanbo, Yu, Canqing, Guo, Yu, Bian, Zheng, Han, Yuting, Yang, Ling, Chen, Yiping, Du, Huaidong, Li, Huimei, Liu, Fang, Chen, Junshi, Chen, Zhengming, Lv, Jun, Li, Liming, on behalf of the China Kadoorie Biobank Collaborative Group, Clarke, Robert, Collins, Rory, Peto, Richard, Walters, Robin, and Avery, Daniel

Subjects
BEHAVIOR modification, CONFIDENCE intervals, CAUSES of death, HEALTH behavior, LONGITUDINAL method, PATIENT compliance, BODY mass index, LIFESTYLES, PROPORTIONAL hazards models, WAIST circumference, DESCRIPTIVE statistics, NON-communicable diseases
Abstract

Background: Adherence to a healthy lifestyle is associated with substantially lower risks of mortality from all causes, cardiovascular diseases, and cancer in white populations. However, little is known about the health benefits among non-white populations. Also, no previous studies have focused on respiratory disease mortality in both white and non-white populations. We assessed the relationships between a combination of healthy lifestyle factors and multiple death outcomes in Chinese adults. Methods: This study included 487,198 adults aged 30–79 years from the China Kadoorie Biobank without heart disease, stroke, and cancer at study enrolment. We defined five healthy lifestyle factors as never smoking or smoking cessation not due to illness; non-daily drinking or moderate alcohol drinking; median or higher level of physical activity; a diet rich in vegetables, fruits, legumes and fish, and limited in red meat; a body mass index of 18.5 to 27.9 kg/m2 and a waist circumference < 90 cm (men)/85 cm (women). Cox regression was used to produce adjusted hazard ratios (HRs) relating these healthy lifestyle factors to all-cause and cause-specific mortality. Results: During a median follow-up of 10.2 years (IQR 9.2–11.1), we documented 37,845 deaths. After multivariable adjustment, the number of healthy lifestyle factors exhibited almost inverse linear relationships with the risks of all-cause and cause-specific mortality. Compared with participants without any healthy factors, the hazard ratio of participants with five healthy factors was 0.32 [95% confidence interval (CI): 0.28, 0.37] for all-cause mortality. The corresponding HRs in specific cause of death were 0.42 (95% CI: 0.26, 0.67) for ischaemic heart disease, 0.21 (95% CI: 0.09, 0.49) for ischaemic stroke, 0.37 (95% CI: 0.22, 0.60) for haemorrhage stroke, 0.36 (95% CI: 0.29, 0.45) for cancer, 0.26 (95% CI: 0.14, 0.48) for respiratory diseases, and 0.29 (95% CI: 0.22, 0.39) for other causes. Theoretically, 38.5% (95% CI: 33.0, 43.8%) of all-cause mortality was attributable to nonadherence to a healthy lifestyle, and the proportions of preventable deaths through lifestyle modification ranged from 26.9 to 47.9% for cause-specific mortality. Conclusions: Adherence to a healthy lifestyle was associated with substantially lower risks of all-cause, cardiovascular, respiratory, and cancer mortality in Chinese adults. Promotion of a healthy lifestyle may considerably reduce the burden of non-communicable diseases in China. [ABSTRACT FROM AUTHOR]

Published
2019
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106. The Genetic Architecture of Depression in Individuals of East Asian Ancestry

Author

Giannakopoulou, Olga, Lin, Kuang, Meng, Xiangrui, Su, Mei-Hsin, Kuo, Po-Hsiu, Peterson, Roseann E., Awasthi, Swapnil, Moscati, Arden, Coleman, Jonathan R. I., Bass, Nick, Millwood, Iona Y., Chen, Yiping, Chen, Zhengming, Chen, Hsi-Chung, Lu, Mong-Liang, Huang, Ming-Chyi, Chen, Chun-Hsin, Stahl, Eli A., Loos, Ruth J. F., Mullins, Niamh, Ursano, Robert J., Kessler, Ronald C., Stein, Murray B., Sen, Srijan, Scott, Laura J., Burmeister, Margit, Fang, Yu, Tyrrell, Jess, Jiang, Yunxuan, Tian, Chao, McIntosh, Andrew M., Ripke, Stephan, Dunn, Erin C., Kendler, Kenneth S., Walters, Robin G., Lewis, Cathryn M., Kuchenbaecker, Karoline, Wray, Naomi R., Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Colodro-Conde, Lucía, Coon, Hilary, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Derks, Eske M., Direk, Nese, Dolan, Conor V., Eley, Thalia C., Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K., Foo, Jerome C., Forstner, Andreas J., Frank, Josef, Gaspar, Héléna A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Grove, Jakob, Hall, Lynsey S., Hansen, Christine Søholm, Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Howard, David M., Hougaard, David M., Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A., Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Kutalik, Zoltán, Li, Yihan, Lind, Penelope A., Luykx, Jurjen J., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., O'Reilly, Paul F., Oskarsson, Hogni, Owen, Michael J., Painter, Jodie N., Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pettersson, Erik, Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shi, Jianxin, Shyn, Stanley I., Sigurdsson, Engilbert, Sinnamon, Grant C. B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thompson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, André G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T, Berger, Klaus, Boomsma, Dorret I., Cichon, Sven, Dannlowski, Udo, de Geus, EJC, DePaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Grabe, Hans J., Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela AF, Magnusson, Patrik K., Martin, Nicholas G., Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Penninx, Brenda WJH, Perlis, Roy H., Porteous, David J., Potash, James B., Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M., Werge, Thomas, Levinson, Douglas F., Breen, Gerome, Børglum, Anders D., Sullivan, Patrick F., Agee, Michelle, Aslibekyan, Stella, Auton, Adam, Babalola, Elizabeth, Bell, Robert K., Bielenberg, Jessica, Bryc, Katarzyna, Bullis, Emily, Cameron, Briana, Coker, Daniella, Cuellar Partida, Gabriel, Dhamija, Devika, Das, Sayantan, Elson, Sarah L., Filshtein, Teresa, Fletez-Brant, Kipper, Fontanillas, Pierre, Freyman, Will, Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Kleinman, Aaron, Kukar, Katelyn, Lane, Vanessa, Lin, Keng-Han, Lowe, Maya, Luff, Marie K., McCreight, Jennifer C., McIntyre, Matthew H., McManus, Kimberly F., Micheletti, Steven J., Moreno, Meghan E., Mountain, Joanna L., Mozaffari, Sahar V., Nandakumar, Priyanka, Noblin, Elizabeth S., O'Connell, Jared, Petrakovitz, Aaron A., Poznik, G. David, Schumacher, Morgan, Shastri, Anjali J., Shelton, Janie F., Shi, Jingchunzi, Shringarpure, Suyash, Tran, Vinh, Tung, Joyce Y., Wang, Xin, Wang, Wei, Weldon, Catherine H., Wilton, Peter, Avery, Daniel, Bennett, Derrick, Bian, Zheng, Boxall, Ruth, Bragg, Fiona, Chan, Ka Hung, Chang, Liang, Chang, Yumei, Chen, Biyun, Chen, Jinyan, Chen, Junshi, Chen, Naying, Chen, Ningyu, Chen, Xiaofang, Cheng, Liang, Clarke, Johnathan, Clarke, Robert, Collins, Rory, Dong, Caixia, Du, Huaidong, Du, Ranran, Fairhurst-Hunter, Zammy, Fan, Lei, Feng, Shixian, Fu, Zhongxi, Gan, Wei, Gao, Ruqin, Gao, Yulian, Ge, Pengfei, Gilbert, Simon, Gong, Weiwei, Gu, Qijun, Guo, Yu, Guo, Zhendong, Guo, Ziyan, Hacker, Alex, Han, Xiao, Hariri, Parisa, He, Pan, He, Tianyou, Hill, Mike, Holmes, Michael, Hou, Can, Hou, Wei, Hu, Chen, Hu, Ruying, Hu, Ximin, Hu, Yihe, Hua, Hua, Hua, Yujie, Huang, Yuelong, Im, Pek Kei, Iona, Andri, Jiang, Qilian, Jin, Jianrong, Kakkoura, Maria, Kang, Quan, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Lan, Jian, Lancaster, Garry, Li, Feifei, Li, Huimei, Li, Jianguo, Li, Liming, Li, Mingqiang, LI, Shanpeng, Li, Yanjie, Li, Yilei, Li, Zhongxiao, Lingli, Lingli, Liu, Chao, Liu, Depei, Liu, Duo, Liu, Fang, Liu, Huilin, Liu, Jiaqiu, Liu, Jingchao, Liu, Yongmei, Liu, Yun, Long, Huajun, Lu, Yan, Luo, Guojin, Lv, Jun, Lv, Silu, Ma, Liangcai, Mao, Enke, McDonnell, John, Meng, Fanwen, Meng, Jinhuai, Millwood, Iona, Nie, Qunhua, Ning, Feng, Pan, Dongxia, Pan, Rong, Pang, Zengchang, Pei, Pei, Peto, Richard, Pozarickij, Alfred, Qian, Yijian, Qin, Yulu, Qu, Chan, Ren, Xiaolan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Su, Jian, Sun, Huarong, Sun, Qiang, Sun, Xiaohui, Tang, Aiyu, Tang, Zhenzhu, Tao, Ran, Tian, Xiaocao, Turnbull, Iain, Walters, Robin, Wan, Meng, Wang, Chunmei, Wang, Chen, Wang, Hao, Wang, Junzheng, Wang, Lin, Wang, Ping, Wang, Tao, Wang, Shaojie, Wang, Sisi, Wang, Xiaohuan, Wei, Liuping, Weng, Min, Wright, Neil, Wu, Ming, Wu, Xianping, Wu, Shukuan, Xie, Kaixu, Xu, Qiaohua, Xu, Qinai, Xu, Xin, Yan, Shichun, Yang, Ling, Yang, Xiaoming, Yang, Jie, Yao, Pang, Yin, Li, Yu, Bo, Yu, Canqing, Yu, Min, Zhai, Yaoming, Zhang, Hao, Zhang, Hui, Zhang, Jun, Zhang, Libo, Zhang, Ningmei, Zhang, Xi, Zhang, Xiaoyi, Zhang, Xukui, Zhong, Xunfu, Zhou, Ding Zhang, Zhou, Gang, Zhou, Jinyi, Zhou, Liyuan, Zhou, Weiwei, Zhou, Xue, Zhou, Yonglin, and Zou, Mingyuan

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107. [Clinical observation of a new anti-VEGF drugs conbercept for wet age-related macular degeneration].

Author

Lu H, Cui J, Dong H, Luo B, Xiu W, and Li H

Subjects
Fluorescein Angiography, Humans, Intravitreal Injections, Macular Edema drug therapy, Retina, Retrospective Studies, Tomography, Optical Coherence, Visual Acuity, Wet Macular Degeneration diagnosis, Angiogenesis Inhibitors therapeutic use, Recombinant Fusion Proteins therapeutic use, Vascular Endothelial Growth Factor A antagonists & inhibitors, Wet Macular Degeneration drug therapy
Abstract

Objective: To observe the efficacy and safety of intravitreal injection of conbercept, a new drugs of VEGFR fusion proteins, on wet age-related macular degeneration (wAMD)., Methods: To analyze retrospectively the clinical data of 58 patients with wet wAMD, which was diagnosed by examination of ETDRS charts, color fundus photograph, fluorescein angiography (FFA) and optical coherence tomography (OCT), were underwent intravitreal injection conbercept 0.5 mg (0.05 ml of 10 g/L). Follow-up time was 6 to 12 months.Visual acuity (ETDRS charts letter), retinal thickness, leakage of CNV and operative complications before and after the treatment were analyzed., Results: Conbercept injection therapeutic times were 3-5, the average therapeutic times were 3.05. At the end of the follow-up period, the mean letter of ETDRS charts was 50.20±12.87, increased 26.20 letters (t=2.936, P<0.01). the ETDRS charts improved 15 or more letters in 33 eyes (53.23%), decreased more than 15 letters in 2 eyes (3.23%); the average foveal thickness on OCT images were (223±74) µm after treatment, decreased significantly (t=3.669, P<0.01) ; FFA showed CNV complete closure in 34 eyes (54.84%), partial closure in 23 eyes (37.10%), no change in 5 eyes (8.06%). IOP increased in 2 eyes after treatment and recovered within one week., Conclusions: Intravitreal injection of conbercept for wAMD was well tolerated, with an improvement in BCVA, macular edema and leakage of CNV, reduce the risk of rehaemorrhagia.

Published
2015

108. Rapid tissue microarray assay of p16 protein expression for different stage nasopharyngeal carcinoma.

Author

Zhang L, Fang Y, Huang B, Hou J, Zhao M, Li H, and Zeng Y

Subjects
Humans, Immunohistochemistry, Nasopharyngeal Neoplasms metabolism, Neoplasm Staging, Cyclin-Dependent Kinase Inhibitor p16 biosynthesis, Nasopharyngeal Neoplasms pathology
Abstract

Objective: To effectively screen p16 protein expression of different clinical stage nasopharyngeal carcinoma (NPC) by constructing and applying high-throughput tissue microarray/tissue chip., Methods: A series of tissue chips were prepared by using tissue arrayer with samples from different clinical stage NPC tumors and noncancerous nasopharynx tissue. Specimens from 259 cases of nasopharyngeal lesions were detected immunohistochemically on a tissue chip for p16 protein expression and the correlation of p16 protein expression to clinical stage of NPC was analyzed statistically., Results: p16 protein expression was detected in all 18 histologically normal nasopharyngeal epithelia. No p16 protein was detected in 3 of 3 (100%) stage I NPC, 38 of 44 (86.3%) stage II NPC, 59 of 68 (86.8%) stage III NPC, 23 of 28 (82.1%) stage IV NPC, 87 of 98 (88.8%) unclear stage NPC. The efficiency of p16 protein expression in NPC tissues was significantly lower than that in normal nasopharyngeal epithelia (chi(2) = 82.58, P < 0.001), and there was no apparent relationship between p16 protein expression and clinical stages (chi(2) = 0.09, P = 0.769)., Conclusions: The frequent deletion of p16 protein in NPC suggests that p16 gene has an important role in the development and progression of NPC. The consistency of p16 protein deletion in different stages of NPC suggests that the deletion of p16 protein is an early event in the development of NPC, and it is feasible to utilize tissue microarray for a rapid, economic and accurate screening of clinical tissue specimens on a large scale.

Published
2002

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