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The hardware‐level construction of artificial synapses, mimicking the functionality of biological synapses, is widely acknowledged as a pivotal stride in artificial intelligence systems. Particularly, establishing all‐optical artificial synapses for neuromorphic computing, leveraging on‐chip optical interconnects instead of conventional wired connections, has garnered widespread attention. Here, high‐quality CsPbBr3 single crystals are synthesized, and intriguing relaxation processes associated with reversible photo‐induced phase transition (PIPT) are observed, leading to a corresponding change in the birefringence effect. The birefringence change is systematically analyzed by an optical system. The relaxation time of reversible PIPT is similar to the behavior patterns of biological synapses, enabling the device to mimic synaptic features. The device successfully mimics excitatory/inhibitory synaptic behaviors such as EPSP/IPSP, PPF, SDDP, SFDP, and SIDP by using 1310 nm signal. Furthermore, the device continues to exhibit excitatory/inhibitory synaptic functionality when 940 and 1550 nm signals are applied, achieving multi‐wavelength synaptic behaviors. The all‐optical devices have the advantages of low crosstalk, fast signaling, and wide optical bandwidth, which lays the foundation of all‐optical hardware for neuromorphic computing systems. [ABSTRACT FROM AUTHOR]

Persistent human papillomavirus (HPV) infection is associated with multiple malignancies. Developing therapeutic vaccines to eliminate HPV‐infected and malignant cells holds significant value. In this study, we introduced a lipid nanoparticle encapsulated mRNA vaccine expressing tHA‐mE7‐mE6. Mutations were introduced into E6 and E7 of HPV to eliminate their tumourigenicity. A truncated influenza haemagglutinin protein (tHA), which binds to the CD209 receptor on the surface of dendritic cells (DCs), was fused with mE7‐mE6 in order to allow efficient uptake of antigen by antigen presenting cells. The tHA‐mE7‐mE6 (mRNA) showed higher therapeutic efficacy than mE7‐mE6 (mRNA) in an E6 and E7+ tumour model. The treatment resulted in complete tumour regression and prevented tumour formation. Strong CD8+ T‐cell immune response was induced, contributing to preventing and curing of E6 and E7+ tumour. Antigen‐specific CD8+ T were found in spleens, peripheral blood and in tumours. In addition, the tumour infiltration of DC and NK cells were increased post therapy. In conclusion, this study described a therapeutic mRNA vaccine inducing strong anti‐tumour immunity in peripheral and in tumour microenvironment, holding promising potential to treat HPV‐induced cancer and to prevent cancer recurrence. [ABSTRACT FROM AUTHOR]

Carbon dioxide geological storage is one of the key measures to control and alleviate atmospheric carbon dioxide content. To better grasp the developmental dynamic and trend of carbon dioxide geological storage research over the world, promoting the research of CO2 storage theory and technology, 5052 related studies published in the past 22 years were collected from the Web Of Science database. The annual published articles on carbon dioxide geological storage research, partnerships, research hotspots, and frontiers were analyzed by using the knowledge map method of article analysis. The results show that the articles on the carbon dioxide geological storage are increasing yearly. The United States, China, and the United Kingdom are the most active countries; meanwhile, Tianfu Xu and Xiaochun Li from China are experts with the most achievements in the field of carbon dioxide geological storage. Although the theoretical and research frameworks for geological storage of CO2 are abundant, the field of enhanced gas formation recovery, shale gas extraction and subsurface storage, methane reservoirs, and methane adsorption are still challenging frontier science and technology topics. [ABSTRACT FROM AUTHOR]

High-quality economic development is an inevitable requirement for promoting sustainable development. Stacks of research papers have suggested that the quality of China's economic development will make an important contribution to promoting global sustainable development. The collaborative agglomeration between manufacturing and producer services is determined by multiple factors, including industrial characteristics and industrial associations. This is conducive to the efficient evolution of the industrial structure and to further achieving high-quality economic development. Based on the provincial data from 2010 to 2021 in China, this research evaluated the impact of co-agglomeration between manufacturing and producer services on high-quality economic development by using the double-fixed-effect spatial Durbin model. The benchmark regression results showed that industrial co-agglomeration impacted high-quality economic development in an inverted U-shaped. This result had a significant positive spatial spillover and was robust. In the spatial heterogeneity tests, the co-agglomeration of industries had different effects on high-quality development in regions. The strongest spillover effect of positive externalities was in the eastern region, which played an active role as a "growth pole". The "siphon effect" happened in the central region. The spillover effect had a "U" shape in the western region, and the co-agglomeration inhibited current high-quality development. In the mechanism analysis, the industrial co-agglomeration enhanced high-quality development by stimulating green innovation, and the digital economy had a positive moderating effect. The study presented in this article provides empirical evidence and offers policy recommendations for formulating industrial policies and improving the quality of economic development. [ABSTRACT FROM AUTHOR]

Self‐disclosure (SD) is a common psychological intervention that involves expressing the patient's feelings and thoughts. The purpose of this study was to assess the effectiveness of different themes of SD on cancer patients. We searched eight databases including PubMed, Cochrane Library Trials, Web of Science, CINAHL, Medline, EMBASE, CNKI and Wanfang from inception to July 2022. Other sources included clinical data registers. The Cochrane Collaboration's tool was used to assess the risk of bias in the included studies. RevMan Analysis software 5.3 was used for data analysis. The protocol of this meta‐analysis has been registered on PROSPERO (CRD42022339661). Twenty‐two RCTs studies were included. The pooled results demonstrated that self‐regulation self‐disclosure (SRD) had significant effects on patients' sleep quality, benefit‐finding, anxiety and quality of life (QOL), whereas emotional disclosure (ED) did not. Furthermore, enhanced self‐regulation self‐disclosure (ESRD) or cancer‐related self‐disclosure (CD) significantly improved patients' QOL, although health education self‐disclosure (HED) and positive self‐disclosure (PD) did not. Our study suggests that different themes of SD have varied effects on patients, but it remains unclear which themes to use at what point in time. Future research should investigate what themes of SD are adopted at different points in time and the duration of different periods. [ABSTRACT FROM AUTHOR]

Due to the aging of trees, aged apple and cherry orchards need to be rebuilt urgently. However, due to the limitation of land resources, it is inevitable to rebuild the apple orchard by taking the aged cherry orchard as a replacement, which will lead to replant disease and seriously affect the sustainable development of the horticulture industry. This study investigated the effect of aged cherry orchard soil on the growth of M. hupehensis seedlings grown in pots, and it was further verified that allelochemicals in soil were one of the reasons for this effect. Three treatments were implemented: aged apple orchard soil (ppl), aged cherry orchard soil (pyl), and aged cherry orchard soil after fumigation with methyl bromide (pyz). Compared with pyz, pyl treatment significantly decreased the biomass, root growth, and antioxidant enzyme activity of M. hupehensis seedlings, and increased the content of MDA. Compared with ppl, pyl contains a smaller number of fungi and bacteria, but the abundance of the four disease-causing Fusarium remained high. In addition, the levels of allelochemicals found in the soil of aged cherry orchards can inhibit the normal growth and development of M. hupehensis seedlings. Amygdalin most strongly inhibited these seedlings. In summary, directly planting M. hupehensis seedlings in the soil of the aged cherry orchards still inhibits their normal growth and development, although the seedlings grow better than in aged apple orchard soil. Therefore, it is not feasible to directly plant M. hupehensis seedlings in the soil of aged cherry orchards, and measures should be taken to eliminate allelochemicals such as amygdalin and harmful microorganisms. [ABSTRACT FROM AUTHOR]

Lead-free all-inorganic metal halide perovskites have garnered significant interest due to their exceptional optical and electrical applications. In addition, patterned perovskite films could enhance the performance of the perovskite-based devices. In this work, the microscale cylinder arrays with various diameters were fabricated on Si(100) substrates, and the Cs3Cu2I5 thin films were deposited on the microarrays by pulsed laser deposition. Then, the Cs3Cu2I5/Si heterojunction photodetectors were constructed with Ni/Au and Au electrodes. The reflectivity and photoluminescence spectra demonstrated that the microarrays can reduce surface reflectivity and increase light absorption in heterojunction devices. In addition, the microscale arrays improved the Cs3Cu2I5/Si heterojunction photodetectors performance. As the array diameter decreased, the peak responsivity and specific detectivity of the photodetectors increased significantly, reaching 124.4 mA/W for a 4 μm array. In addition, the photodetectors on microscale arrays demonstrated improved stability with a slightly reduced response speed. The results highlight the potential for microscale structures in enhancing optoelectronic devices. [ABSTRACT FROM AUTHOR]

The main goal of this paper is to show that international peer review can work in China’s context with satisfactory outcomes. Moreover, this paper also provides a reference for the practice of science and technology management.

Traditional seismic evaluations for high‐voltage switchgear equipment, the critical power facilities, consider only structural failure mode and may underestimate the actual seismic risk. By additionally introducing a probable functional failure mode caused by the excessive deformation of the switchable blade of equipment, a novel copula‐based framework is proposed to utilize limited samples to generate simulation data and evaluate the joint failure probability (JFP). The correlation index and Akaike Information Criterion are employed to optimize the Copula function. For illustration, a disconnector, representative switchgear equipment, was selected as an example and modeled with the experiment validation. Model analysis results demonstrate the Clayton type is the most competent for evaluation. Neglecting functional failure can significantly underestimate the actual failure probability at various seismic intensities, up to 50%. Furthermore, it was found that the current equipment material strength level already meets the requirements, and enhancing strength alone does not effectively improve reliability under strong earthquakes. For PGA intensities ≥0.7 g, the blade deformation capacity plays the primary reliability constraint, independent of material stress. A cost‐effective seismic design should optimize the combination of allowable material stress and blade deformation based on the JFP considering seismic intensity and targeted reliability. [ABSTRACT FROM AUTHOR]

Studies have found that the digital economy plays a positive role in promoting high-quality economic development. Meanwhile, the digital industrialization and industrial digitalization have given rise to new demands and supply modes of consumption. It is necessary to analyze the role of consumption expansion in the impact of digital economy on high-quality economic development. Based on Chinese provincial panel data, we first applied the entropy weight method to construct the digital economy index and the high-quality economic development index. And on this basis, it was verified that the digital economy can positively promote the high-quality development of the inverted U-shaped structural economy. Then we separately used the mediation and the threshold effect models to analyze the role of consumption expansion in empowering high-quality development in the digital economy. Regional heterogeneity was further taken into account. The results dedicate that consumer demand and the digital economy have a partial or complete mediating effect. The promotion of high-quality development by the digital economy can be affected by the threshold of consumption expansion, which is manifested in the marginal incremental effect due to the growth of consumption supply. On the contrary, the growth of consumer demand has led to the inverted U-shape of the digital economy to promote high-quality economic development. In the heterogeneity analysis, the threshold effect also varied greatly. This research enriches the theoretical achievements and reveals the impact of consumption expansion on the digital economy affecting the high-quality development, which may provide certain reference for other countries and regions. [ABSTRACT FROM AUTHOR]