1,310 results on '"Limburg, P."'
Search Results
102. Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis
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Seth R Flaxman, PhD, Rupert R A Bourne, ProfMD, Serge Resnikoff, ProfMD, Peter Ackland, MPhil, Tasanee Braithwaite, MPH, Maria V Cicinelli, MD, Aditi Das, MD, Jost B Jonas, ProfMD, Jill Keeffe, ProfPhD, John H Kempen, MD, Janet Leasher, ProfOD, Hans Limburg, PhD, Kovin Naidoo, PhD, Konrad Pesudovs, ProfPhD, Alex Silvester, MD, Gretchen A Stevens, D.Sc, Nina Tahhan, PhD, Tien Y Wong, ProfPhD, Hugh R Taylor, MD, Rupert Bourne, Peter Ackland, Aries Arditi, Yaniv Barkana, Banu Bozkurt, Tasanee Braithwaite, Alain Bron, Donald Budenz, Feng Cai, Robert Casson, Usha Chakravarthy, Jaewan Choi, Maria Vittoria Cicinelli, Nathan Congdon, Reza Dana, Rakhi Dandona, Lalit Dandona, Aditi Das, Iva Dekaris, Monte Del Monte, Jenny deva, Laura Dreer, Leon Ellwein, Marcela Frazier, Kevin Frick, David Friedman, Joao Furtado, Hua Gao, Gus Gazzard, Ronnie George, Stephen Gichuhi, Victor Gonzalez, Billy Hammond, Mary Elizabeth Hartnett, Minguang He, James Hejtmancik, Flavio Hirai, John Huang, April Ingram, Jonathan Javitt, Jost Jonas, Charlotte Joslin, Jill Keeffe, John Kempen, Moncef Khairallah, Rohit Khanna, Judy Kim, George Lambrou, Van Charles Lansingh, Paolo Lanzetta, Janet Leasher, Jennifer Lim, Hans LIMBURG, Kaweh Mansouri, Anu Mathew, Alan Morse, Beatriz Munoz, David Musch, Kovin Naidoo, Vinay Nangia, Maria Palaiou, Maurizio Battaglia Parodi, Fernando Yaacov Pena, Konrad Pesudovs, Tunde Peto, Harry Quigley, Murugesan Raju, Pradeep Ramulu, Zane Rankin, Serge Resnikoff, Dana Reza, Alan Robin, Luca Rossetti, Jinan Saaddine, Mya Sandar, Janet Serle, Tueng Shen, Rajesh Shetty, Pamela Sieving, Juan Carlos Silva, Alex Silvester, Rita S. Sitorus, Dwight Stambolian, Gretchen Stevens, Hugh Taylor, Jaime Tejedor, James Tielsch, Miltiadis Tsilimbaris, Jan van Meurs, Rohit Varma, Gianni Virgili, Ya Xing Wang, Ning-Li Wang, Sheila West, Peter Wiedemann, Tien Wong, Richard Wormald, and Yingfeng Zheng
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Public aspects of medicine ,RA1-1270 - Abstract
Summary: Background: Contemporary data for causes of vision impairment and blindness form an important basis of recommendations in public health policies. Refreshment of the Global Vision Database with recently published data sources permitted modelling of cause of vision loss data from 1990 to 2015, further disaggregation by cause, and forecasts to 2020. Methods: In this systematic review and meta-analysis, we analysed published and unpublished population-based data for the causes of vision impairment and blindness from 1980 to 2014. We identified population-based studies published before July 8, 2014, by searching online databases with no language restrictions (MEDLINE from Jan 1, 1946, and Embase from Jan 1, 1974, and the WHO Library Database). We fitted a series of regression models to estimate the proportion of moderate or severe vision impairment (defined as presenting visual acuity of 14% of blindness) as causes in the high-income subregions. Blindness and vision impairment at all ages in 2015 due to diabetic retinopathy (odds ratio 2·52 [1·48–3·73]) and cataract (1·21 [1·17–1·25]) were more common among women than among men, whereas blindness and vision impairment due to glaucoma (0·71 [0·57–0·86]) and corneal opacity (0·54 [0·43–0·66]) were more common among men than among women, with no sex difference related to age-related macular degeneration (0·91 [0·70–1·14]). Interpretation: The number of people affected by the common causes of vision loss has increased substantially as the population increases and ages. Preventable vision loss due to cataract (reversible with surgery) and refractive error (reversible with spectacle correction) continue to cause most cases of blindness and moderate or severe vision impairment in adults aged 50 years and older. A large scale-up of eye care provision to cope with the increasing numbers is needed to address avoidable vision loss. Funding: Brien Holden Vision Institute.
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- 2017
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103. Body mass index and molecular subtypes of colorectal cancer.
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Murphy, N, Newton, CC, Song, M, Papadimitriou, N, Hoffmeister, M, Phipps, AI, Harrison, TA, Newcomb, PA, Aglago, EK, Berndt, SI, Brenner, H, Buchanan, DD, Cao, Y, Chan, AT, Chen, X, Cheng, I, Chang-Claude, J, Dimou, N, Drew, D, Farris, AB, French, AJ, Gallinger, S, Georgeson, P, Giannakis, M, Giles, GG, Gruber, SB, Harlid, S, Hsu, L, Huang, W-Y, Jenkins, MA, Laskar, RS, Le Marchand, L, Limburg, P, Lin, Y, Mandic, M, Nowak, JA, Obón-Santacana, M, Ogino, S, Qu, C, Sakoda, LC, Schoen, RE, Southey, MC, Stadler, ZK, Steinfelder, RS, Sun, W, Thibodeau, SN, Toland, AE, Trinh, QM, Tsilidis, KK, Ugai, T, Van Guelpen, B, Wang, X, Woods, MO, Zaidi, SH, Gunter, MJ, Peters, U, Campbell, PT, Murphy, N, Newton, CC, Song, M, Papadimitriou, N, Hoffmeister, M, Phipps, AI, Harrison, TA, Newcomb, PA, Aglago, EK, Berndt, SI, Brenner, H, Buchanan, DD, Cao, Y, Chan, AT, Chen, X, Cheng, I, Chang-Claude, J, Dimou, N, Drew, D, Farris, AB, French, AJ, Gallinger, S, Georgeson, P, Giannakis, M, Giles, GG, Gruber, SB, Harlid, S, Hsu, L, Huang, W-Y, Jenkins, MA, Laskar, RS, Le Marchand, L, Limburg, P, Lin, Y, Mandic, M, Nowak, JA, Obón-Santacana, M, Ogino, S, Qu, C, Sakoda, LC, Schoen, RE, Southey, MC, Stadler, ZK, Steinfelder, RS, Sun, W, Thibodeau, SN, Toland, AE, Trinh, QM, Tsilidis, KK, Ugai, T, Van Guelpen, B, Wang, X, Woods, MO, Zaidi, SH, Gunter, MJ, Peters, U, and Campbell, PT
- Abstract
BACKGROUND: Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease. METHODS: We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, and Jass classification types for 11 872 CRC cases and 11 013 controls from 11 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for covariables. RESULTS: Higher BMI was associated with increased CRC risk (OR per 5 kg/m2 = 1.18, 95% CI = 1.15 to 1.22). The positive association was stronger for men than women but similar across tumor subtypes defined by individual molecular markers. In analyses by Jass type, higher BMI was associated with elevated CRC risk for types 1-4 cases but not for type 5 CRC cases (considered familial-like/Lynch syndrome microsatellite instability-H, CpG island methylator phenotype-low or negative, BRAF-wild type, KRAS-wild type, OR = 1.04, 95% CI = 0.90 to 1.20). This pattern of associations for BMI and Jass types was consistent by sex and design of contributing studies (cohort or case-control). CONCLUSIONS: In contrast to previous reports with fewer study participants, we found limited evidence of heterogeneity for the association between BMI and CRC risk according to molecular subtype, suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The null association observed for the Jass type 5 suggests that BMI is not a risk factor for the development of CRC for individuals with Lynch syndrome.
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- 2023
104. Cataract indicators: their development and use over the last 30 years
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Hans Limburg and Jacqui Ramke
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cataract indicators ,cataract surgery ,cataract surgical rate ,Ophthalmology ,RE1-994 - Abstract
How do we know if our cataract service is reaching enough (and the right) people? How can we tell whether the quality of surgery is good enough? Understanding cataract indicators, and how to use them, can help us to meet the community’s needs.
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- 2018
105. Effect of Marine Hypoxia on Baltic Sea Cod Gadus morhua: Evidence From Otolith Chemical Proxies
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Karin E. Limburg and Michele Casini
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Baltic cod ,hypoxia ,otolith microchemistry ,manganese ,magnesium ,growth effects ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
The Baltic Sea contains the world’s largest anthropogenic deoxygenated zone, with increasing episodes and areal extent of hypoxia/anoxia. Atlantic cod in the Baltic has suffered a loss in condition which has been attributed mainly to hypoxia. Otoliths, the aragonitic structures that form part of the hearing/balance system in fishes, accumulate Mn in the presence of hypoxia and other reducing environments. Otoliths grow over the lifetime of fishes, and thus life-long records of hypoxia exposure exist for each individual fish. However, otolith Mn/Ca ratios are also sensitive to growth effects. We tested a new proxy to at least partially account for growth: Mn/Mg, since Mg levels reflect metabolic activity but not hypoxia. This and other elemental proxies were parsed annually from the otoliths to reconstruct lifetime histories of mean, maximum, and cumulative values of this proxy as well as others (Sr/Ca) that inform us about salinity conditions. We analyzed cod from five different time periods: Neolithic (4500 YBP, a normoxic baseline), 1980s, 1990s, 2000s, and 2010s – under different hypoxia intensities, assessing fish growth and condition in relation to hypoxia experience recorded by otolith proxies. Fish growth decreased with increasing hypoxia exposure; condition at capture (measured by Fulton’s K index) showed a strongly positive relation to growth indexed by magnesium (Mg/Ca). We conclude that cod otolith chemistry proxies not only inform about the hypoxia, growth, and metabolic status of cod, retrospectively throughout life, but also reflect the worsening situation for cod in the Baltic.
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- 2018
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106. Neurologists' Assessment of Mental Comorbidity in Patients With Vertigo and Dizziness in Routine Clinical Care—Comparison With a Structured Clinical Interview
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Karina Limburg, Andreas Dinkel, Gabriele Schmid-Mühlbauer, Heribert Sattel, Katharina Radziej, Sandra Becker-Bense, Peter Henningsen, Marianne Dieterich, and Claas Lahmann
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structured clinical interviews for mental disorders ,vertigo ,dizziness ,psychiatric disorders ,diagnostic agreement ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Background: Mental health comorbidities are frequent in patients with vertigo and dizziness. The current study was conducted in a specialized interdisciplinary university center for vertigo and dizziness. Clinical routines consist of a structured work-up in which neuro-otological and neurological tests are performed to first detect possible organic vestibular deficits. In addition, psychiatric disorders and comorbidities are considered. The study aimed to evaluate neurologists' awareness of psychiatric next to somatic disorders within patients' first examination in terms of diagnostic congruence between neurologists' diagnoses and structured clinical assessment of mental disorders.Methods: The study involved 392 patients. Diagnostic evaluation included (a) structured history-taking (including psychosocial anamnesis), neurological, and neuro-otological diagnostics conducted by neurologists and (b) a structured clinical interview for mental disorders (SCID-I) conducted by psychologists and final-year medical or psychology students. Cohen's Kappa was calculated to determine agreement rates regarding depression and anxiety disorders; additionally, sensitivity and specificity were evaluated.Results: Neurologists' assessments led to at least one psychiatric diagnosis among the main diagnoses in 40 (10.2 %) patients, whereas the structured clinical interview led to at least one DSM-IV psychiatric diagnosis in 174 (44.4%) of the patients. Agreement was low (κ < 0.2); sensitivity was low (15%) but specificity was high (98%).Conclusions: Agreement between the diagnosis of neurologists and structured clinical interviews for psychiatric disorders is low. Since psychiatric disorders are frequent in vertigo and dizziness and tend to take a chronic course, improving early recognition and implementing appropriate care concepts is vital.
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- 2018
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107. Children’s Technology Time in Two US Cohorts
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Goode, Joshua A., Fomby, Paula, Mollborn, Stefanie, and Limburg, Aubrey
- Abstract
Over the last two decades, technologies available to children have accelerated with the advent of wireless internet and increasing portability and affordability of electronic devices. Children’s technology use is a rapidly evolving challenge for families, organizing their everyday lives and potentially resulting in social disparities in technology use and displacement of healthy behaviors. This study examined time spent on technology use, physical activity, play, and sleep by US children across early (ages 2–5) and middle (ages 6–11) childhood in two cohorts using time diary data with a focus on variation by class and race. Data came from the Panel Study of Income Dynamics Child Development Supplement in 1997 (N= 2193) and 2014–2016 (N= 1009). Multivariate regression models estimated total time spent engaged in technology use, physical activity, unstructured play, and sleep. Total time spent engaged with technology increased 32% since 1997 in early childhood and 23% in middle childhood. Technology use was lowest for children with the most highly educated parents. In the more recent cohort, technology use was associated with displacement of physical activity in middle childhood but with increased play in early childhood and increased sleep in middle childhood. Results suggest that changes over time in technology use have restructured children’s everyday lives in ways that may be consequential for health and development, but co-occurring declines in physical activity and unstructured play cannot be attributed solely to technology time.
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- 2024
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108. Understanding resonant charge transport through weakly coupled single-molecule junctions
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Thomas, James O., Limburg, Bart, Sowa, Jakub K., Willick, Kyle, Baugh, Jonathan, Briggs, G. Andrew D., Gauger, Erik M., Anderson, Harry L., and Mol, Jan A.
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- 2019
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109. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis
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Prof Rupert R A Bourne, MD, Seth R Flaxman, BA, Tasanee Braithwaite, MPH, Maria V Cicinelli, MD, Aditi Das, MD, Jost B Jonas, MD, Jill Keeffe, PhD, John H Kempen, MD, Janet Leasher, OD, Hans Limburg, PhD, Kovin Naidoo, PhD, Konrad Pesudovs, PhD, Serge Resnikoff, MD, Alex Silvester, MD, Gretchen A Stevens, DSc, Nina Tahhan, PhD, Tien Y Wong, PhD, Hugh R Taylor, MD, Rupert Bourne, Peter Ackland, Aries Arditi, Yaniv Barkana, Banu Bozkurt, TASANEE BRAITHWAITE, Alain Bron, Donald Budenz, Feng Cai, Robert Casson, Usha Chakravarthy, Jaewan Choi, Maria Vittoria Cicinelli, Nathan Congdon, Reza Dana, Rakhi Dandona, Lalit Dandona, Aditi Das, Iva Dekaris, Monte Del Monte, Jenny Deva, Laura Dreer, Leon Ellwein, Marcela Frazier, Kevin Frick, David Friedman, Joao Furtado, Hua Gao, Gus Gazzard, Ronnie George, Stephen Gichuhi, Victor Gonzalez, Billy Hammond, Mary Elizabeth Hartnett, Minguang He, James Hejtmancik, Flavio Hirai, John Huang, April Ingram, Jonathan Javitt, Jost Jonas, Charlotte Joslin, Jill Keeffe, John Kempen, Moncef Khairallah, Rohit Khanna, Judy Kim, George Lambrou, Van Charles Lansingh, Paolo Lanzetta, Janet Leasher, Jennifer Lim, Hans LIMBURG, Kaweh Mansouri, Anu Mathew, Alan Morse, Beatriz Munoz, David Musch, Kovin Naidoo, Vinay Nangia, MARIA PALAIOU, Maurizio Battaglia Parodi, Fernando Yaacov Pena, Konrad Pesudovs, Tunde Peto, Harry Quigley, Murugesan Raju, Pradeep Ramulu, Serge Resnikoff, Alan Robin, Luca Rossetti, Jinan Saaddine, MYA SANDAR, Janet Serle, Tueng Shen, Rajesh Shetty, Pamela Sieving, Juan Carlos Silva, Alex Silvester, Rita S Sitorus, Dwight Stambolian, Gretchen Stevens, Hugh Taylor, Jaime Tejedor, James Tielsch, Miltiadis Tsilimbaris, Jan van Meurs, Rohit Varma, Gianni Virgili, Jimmy Volmink, Ya Xing Wang, Ning-Li Wang, Sheila West, Peter Wiedemann, Tien Wong, Richard Wormald, and Yingfeng Zheng
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Public aspects of medicine ,RA1-1270 - Abstract
Background: Global and regional prevalence estimates for blindness and vision impairment are important for the development of public health policies. We aimed to provide global estimates, trends, and projections of global blindness and vision impairment. Methods: We did a systematic review and meta-analysis of population-based datasets relevant to global vision impairment and blindness that were published between 1980 and 2015. We fitted hierarchical models to estimate the prevalence (by age, country, and sex), in 2015, of mild visual impairment (presenting visual acuity worse than 6/12 to 6/18 inclusive), moderate to severe visual impairment (presenting visual acuity worse than 6/18 to 3/60 inclusive), blindness (presenting visual acuity worse than 3/60), and functional presbyopia (defined as presenting near vision worse than N6 or N8 at 40 cm when best-corrected distance visual acuity was better than 6/12). Findings: Globally, of the 7·33 billion people alive in 2015, an estimated 36·0 million (80% uncertainty interval [UI] 12·9–65·4) were blind (crude prevalence 0·48%; 80% UI 0·17–0·87; 56% female), 216·6 million (80% UI 98·5–359·1) people had moderate to severe visual impairment (2·95%, 80% UI 1·34–4·89; 55% female), and 188·5 million (80% UI 64·5–350·2) had mild visual impairment (2·57%, 80% UI 0·88–4·77; 54% female). Functional presbyopia affected an estimated 1094·7 million (80% UI 581·1–1686·5) people aged 35 years and older, with 666·7 million (80% UI 364·9–997·6) being aged 50 years or older. The estimated number of blind people increased by 17·6%, from 30·6 million (80% UI 9·9–57·3) in 1990 to 36·0 million (80% UI 12·9–65·4) in 2015. This change was attributable to three factors, namely an increase because of population growth (38·4%), population ageing after accounting for population growth (34·6%), and reduction in age-specific prevalence (−36·7%). The number of people with moderate and severe visual impairment also increased, from 159·9 million (80% UI 68·3–270·0) in 1990 to 216·6 million (80% UI 98·5–359·1) in 2015. Interpretation: There is an ongoing reduction in the age-standardised prevalence of blindness and visual impairment, yet the growth and ageing of the world's population is causing a substantial increase in number of people affected. These observations, plus a very large contribution from uncorrected presbyopia, highlight the need to scale up vision impairment alleviation efforts at all levels. Funding: Brien Holden Vision Institute.
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- 2017
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110. Assessment of Stool DNA Markers to Detect Colorectal Neoplasia in Patients with Inflammatory Bowel Disease: A Multi-site Case-control Study.
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Itzkowitz, Steven, Farraye, Francis A, Limburg, Paul J, Gagrat, Zubin, Olson, Marilyn C, Zella, Julia, and Kisiel, John B
- Abstract
Background and Aims The FDA-approved multitarget stool-DNA [mt-sDNA] test is a successful colorectal cancer [CRC] screening tool in average-risk individuals but is not indicated for patients with inflammatory bowel disease [IBD]. We determined the performance of the mt-sDNA assay without the haemoglobin component [mt-sDNA
Hgb-] in patients with IBD, while measuring sensitivity for colorectal cancer and advanced colorectal neoplasia [ACRN]. Methods This was a multi-centre, proof-of-concept investigation in persons aged 18–84 years with a diagnosis of IBD, or primary sclerosing cholangitis [PSC] with IBD. Enrolment occurred between March 2013 and May 2016. Stool was tested with the mt-sDNA molecular markers only, minus the immunochemical haemoglobin component. Results The analysis set contained 355 samples. The median age was 52 [range 39–62] years, 45.6% were female and 93% were White. Two-thirds [63%] had ulcerative colitis [UC] and 10.1% had PSC/IBD. Colonoscopy revealed cancer in 8.5% [ N = 30], advanced precancerous lesions [APLs] in 9.3% [ N = 33] and non-advanced precancerous lesions in 7.6% [ N = 27], and three-quarters [74.7%, N = 265] had negative findings. mt-sDNAHgb- sensitivity was 73.3% for any stage cancers, and 76.2% for ACRN. Sensitivity was highest for IBD-associated high-grade dysplasia at 100% and 84.6% for IBD-associated low-grade dysplasia ≥1 cm. The test showed higher sensitivity and lower specificity in UC than in Crohn's disease. Increasing inflammation score was associated with a significant decrease in mt-sDNAHgb- test score [ = 0.028] amongst neoplasia-negative individuals, but not in patients with ACRN. Conclusions These data highlight the potential of multitarget stool-DNA marker testing as an important addition to colorectal cancer surveillance by complementing colonoscopic evaluations in IBD patients. [ABSTRACT FROM AUTHOR]- Published
- 2023
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111. Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice
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Fleur Schaper, Mirjan M van Timmeren, Arjen Petersen, Gerda Horst, Marc Bijl, Pieter C Limburg, Johanna Westra, and Peter Heeringa
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Therapeutics. Pharmacology ,RM1-950 ,Biochemistry ,QD415-436 - Abstract
Abstract High mobility group box 1 (HMGB1) is a nuclear DNA binding protein that acts as an alarmin when secreted. HMGB1 is increased in systemic lupus erythematosus and might represent a potential therapeutic target. We investigated whether treatment with an anti-HMGB1 antibody affects the development of lupus nephritis in MRL/lpr mice. Seven-week-old MRL/lpr mice were injected intraperitoneally twice weekly for 10 wks with 50 µg monoclonal anti-HMGB1 (2G7, mouse IgG2b) (n = 12) or control antibody (n = 11). Control MRL/MPJ mice (n = 10) were left untreated. Every 2 wks, blood was drawn and urine was collected at wk 7, 11 and 17. Mice were sacrificed at 17 wks for complete disease evaluation. Plasma HMGB1 and anti-HMGB1 levels were increased in MRL/lpr mice compared with control MRL/MPJ mice. There were no differences in albuminuria, urine HMGB1 and plasma levels of complement C3, anti-dsDNA and proinflammatory cytokines between untreated and treated mice at any time point. Lupus nephritis of mice treated with anti-HMGB1 monoclonal antibody (mAb) was classified as class III (n = 3) and class IV (n = 9), while mice treated with control mAb were classified as class II (n = 4), class III (n = 2) and class IV (n = 5). IgG and C3 deposits in kidneys were similar in mice treated with anti-HMGB1 mAb or control mAb. In conclusion, treatment with monoclonal anti-HMGB-1 antibody 2G7 does not affect development of lupus nephritis, disease progression or proinflammatory cytokine levels in MRL/lpr mice. This result indicates that blocking of HMGB1 by this neutralizing antibody does not affect lupus nephritis in MRL/lpr mice.
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- 2016
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112. Temporal and spatial dynamics of a “Rust-Belt” urban stream: Metabolic and water quality responses to hardened land
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Limburg, K. E., Swaney, D. P., and Hall, M. H.
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- 2016
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113. Estimates of visual impairment and its causes from the National Eye Survey in Malaysia (NESII).
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Fiona L M Chew, Mohamad Aziz Salowi, Zuraidah Mustari, Mohd Aziz Husni, Elias Hussein, Tassha Hilda Adnan, Nor Fariza Ngah, Hans Limburg, and Pik-Pin Goh
- Subjects
Medicine ,Science - Abstract
BACKGROUND:Population-based data on prevalence, causes of blindness and extent of ophthalmological coverage is required for efficient implementation and evaluation of ocular health programs. In view of the scarcity of prevalence data for visual impairment and blindness in Malaysia, this study aims to estimate the prevalence and causes of visual impairment (VI) in the elderly, using Rapid Assessment of Avoidable Blindness (RAAB) survey technique. METHODS:Malaysia was divided into six regions, with each region consisting of 50 clusters. Multistage cluster sampling method was used and each cluster contained 50 residents aged 50 years and above. Eligible subjects were interviewed and pertinent demographic details, barriers to cataract surgery, medical and ocular history was noted. Subjects had visual acuity assessment with tumbling 'E' Snellen optotypes and ocular examination with direct ophthalmoscope. The primary cause of VI was documented. Results were calculated for individual zones and weighted average was used to obtain overall prevalence for the country. Inter-regional and overall prevalence for blindness, severe VI and moderate VI were determined. Causes of VI, cataract surgical coverage and barriers to cataract surgery were assessed. RESULTS:A total of 15,000 subjects were examined with a response rate of 95.3%. The age and gender-adjusted prevalence of blindness, severe visual impairment and moderate visual impairment were 1.2% (95% Confidence Interval: 1.0-1.4%), 1.0% (95%CI: 0.8-1.2%) and 5.9% (5.3-6.5%) respectively. Untreated cataract (58.6%), diabetic retinopathy (10.4%) and glaucoma (6.6%) were the commonest causes of blindness. Overall, 86.3% of the causes of blindness were avoidable. Cataract surgical coverage (CSC) in persons for blindness, severe visual impairment and moderate visual impairment was 90%, 86% and 66% respectively. CONCLUSION:Increased patient education and further expansion of ophthalmological services are required to reduce avoidable blindness even further in Malaysia.
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- 2018
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114. Aspirin Prevents Colorectal Cancer by Normalizing EGFR Expression
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Haitao Li, Feng Zhu, Lisa A. Boardman, Lei Wang, Naomi Oi, Kangdong Liu, Xiang Li, Yang Fu, Paul J. Limburg, Ann M. Bode, and Zigang Dong
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Colorectal cancer ,Familial adenomatous polyposis ,Epidermal growth factor receptor ,Cyclooxygenase-2 ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background: Aspirin intake reduces the risk of colorectal cancer (CRC), but the molecular underpinnings remain elusive. Epidermal growth factor receptor (EGFR), which is overexpressed in about 80% of CRC cases, is implicated in the etiology of CRC. Here, we investigated whether aspirin can prevent CRC by normalizing EGFR expression. Methods: Immunohistochemistry staining was performed on paraffin-embedded tissue sections from normal colon mucosa, adenomatous polyps from FAP patients who were classified as regular aspirin users or nonusers. The interplay between cyclooxygenase-2 (COX-2) and EGFR was studied in primary intestinal epithelial cells isolated from ApcMin mice, immortalized normal human colon epithelial cells (HCECs) as well as murine embryonic fibroblasts (MEFs). Results: Immunohistochemistry staining results established that EGFR overexpression is an early event in colorectal tumorigenesis, which can be greatly attenuated by regular use of aspirin. Importantly, EGFR and COX-2 were co-overexpressed and co-localized with each other in FAP patients. Further mechanistic studies revealed that COX-2 overexpression triggers the activation of the c-Jun-dependent transcription factor, activator protein-1 (AP-1), which binds to the Egfr promoter. Binding facilitates the cellular accumulation of EGFR and lowers the threshold required for pre-neoplastic cells to undergo transformation. Conclusion: Aspirin might exert its chemopreventive activity against CRC, at least partially, by normalizing EGFR expression in gastrointestinal precancerous lesions.
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- 2015
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115. Circulating Prostaglandin Biosynthesis in Colorectal Cancer and Potential Clinical Significance
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Haitao Li, Kangdong Liu, Lisa A. Boardman, Yuzhou Zhao, Lei Wang, Yuqiao Sheng, Naomi Oi, Paul J. Limburg, Ann M. Bode, and Zigang Dong
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Colorectal cancer ,Familial adenomatous polyposis ,Thromboxane A2 ,Medicine ,Medicine (General) ,R5-920 - Abstract
Background: Colorectal cancer (CRC) represents the third leading cause of cancer-related death in the United States. Lack of reliable biomarkers remains a critical issue for early detection of CRC. In this study, we investigated the potential predictive values of circulating prostaglandin (PG) biosynthesis in CRC risk. Methods: Profiles of circulating PG biosynthesis and platelet counts were determined in healthy subjects (n = 16), familial adenomatous polyposis (FAP) patients who were classified as regular aspirin users (n = 14) or nonusers (n = 24), and CRC patients with (n = 18) or without FAP history (n = 20). Immunohistochemistry staining was performed on biopsy samples. Results: Analysis of circulating PG biosynthesis unexpectedly revealed that CRC progression is accompanied by a pronounced elevation of circulating thromboxane A2 (TXA2) levels. When a circulating TXA2 level of 1000 pg/mL was selected as a practical cutoff point, 95% of CRC patients were successfully identified. Further study suggested that the TXA2 pathway is constitutively activated during colorectal tumorigenesis and required for anchorage-independent growth of colon cancer cells. Conclusions: This study established the importance of the TXA2 pathway in CRC pathophysiology, and laid the groundwork for introducing a TXA2-targeting strategy to CRC prevention, early detection and management.
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- 2015
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116. EP.17E.03 Using Healthcare Claims to Predict Costs by Stage for Medicare and Commercially Insured Patients with Non-Small Cell Lung Cancer
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Smith, R., Cao, X., Cuyun Carter, G., Fayyaz, I., Pope, A., Ellenberg, P., Zhang, X., Fan, A., Limburg, P., Beer, T.M., and Pyenson, B.
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- 2024
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117. Identification of Lifelines participants at high risk for development of rheumatoid arthritis
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Arends, S, Trouw, L A, Toes, R E M, van Zanten, A, Roozendaal, C, Limburg, P C, Bootsma, H, and Brouwer, E
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- 2017
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118. Quantitative X-ray fluorescence computed tomography for low-Z samples using an iterative absorption correction algorithm
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Rong Huang, Karin Limburg, and Mehis Rohtla
- Subjects
Physics ,QC1-999 - Abstract
X-ray fluorescence computed tomography is often used to measure trace element distributions within low-Z samples, using algorithms capable of X-ray absorption correction when sample self-absorption is not negligible. Its reconstruction is more complicated compared to transmission tomography, and therefore not widely used. We describe in this paper a very practical iterative method that uses widely available transmission tomography reconstruction software for fluorescence tomography. With this method, sample self-absorption can be corrected not only for the absorption within the measured layer but also for the absorption by material beyond that layer. By combining tomography with analysis for scanning X-ray fluorescence microscopy, absolute concentrations of trace elements can be obtained. By using widely shared software, we not only minimized the coding, took advantage of computing efficiency of fast Fourier transform in transmission tomography software, but also thereby accessed well-developed data processing tools coming with well-known and reliable software packages. The convergence of the iterations was also carefully studied for fluorescence of different attenuation lengths. As an example, fish eye lenses could provide valuable information about fish life-history and endured environmental conditions. Given the lens’s spherical shape and sometimes the short distance from sample to detector for detecting low concentration trace elements, its tomography data are affected by absorption related to material beyond the measured layer but can be reconstructed well with our method. Fish eye lens tomography results are compared with sliced lens 2D fluorescence mapping with good agreement, and with tomography providing better spatial resolution.
- Published
- 2017
- Full Text
- View/download PDF
119. Effective cataract surgical coverage: An indicator for measuring quality-of-care in the context of Universal Health Coverage.
- Author
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Jacqueline Ramke, Clare E Gilbert, Arier C Lee, Peter Ackland, Hans Limburg, and Allen Foster
- Subjects
Medicine ,Science - Abstract
OBJECTIVE:To define and demonstrate effective cataract surgical coverage (eCSC), a candidate UHC indicator that combines a coverage measure (cataract surgical coverage, CSC) with quality (post-operative visual outcome). METHODS:All Rapid Assessment of Avoidable Blindness (RAAB) surveys with datasets on the online RAAB Repository on April 1 2016 were downloaded. The most recent study from each country was included. By country, cataract surgical outcome (CSOGood, 6/18 or better; CSOPoor, worse than 6/60), CSC (operated cataract as a proportion of operable plus operated cataract) and eCSC (operated cataract and a good outcome as a proportion of operable plus operated cataract) were calculated. The association between CSC and CSO was assessed by linear regression. Gender inequality in CSC and eCSC was calculated. FINDINGS:Datasets from 20 countries were included (2005-2013; 67,337 participants; 5,474 cataract surgeries). Median CSC was 53.7% (inter-quartile range[IQR] 46.1-66.6%), CSOGood was 58.9% (IQR 53.7-67.6%) and CSOPoor was 17.7% (IQR 11.3-21.1%). Coverage and quality of cataract surgery were moderately associated-every 1% CSC increase was associated with a 0.46% CSOGood increase and 0.28% CSOPoor decrease. Median eCSC was 36.7% (IQR 30.2-50.6%), approximately one-third lower than the median CSC. Women tended to fare worse than men, and gender inequality was slightly higher for eCSC (4.6% IQR 0.5-7.1%) than for CSC (median 2.3% IQR -1.5-11.6%). CONCLUSION:eCSC allows monitoring of quality in conjunction with coverage of cataract surgery. In the surveys analysed, on average 36.7% of people who could benefit from cataract surgery had undergone surgery and obtained a good visual outcome.
- Published
- 2017
- Full Text
- View/download PDF
120. Emotional processing and rTMS: does inhibitory theta burst stimulation affect the human startle reflex?
- Author
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Vennewald, Nadja, Winter, Bernward, Limburg, Karina, Diemer, Julia, Notzon, Swantje, Fohrbeck, Inga, Arolt, Volker, Domschke, Katharina, Pauli, Paul, and Zwanzger, Peter
- Published
- 2016
- Full Text
- View/download PDF
121. A Matter of Taste? Quality of Life in Day-to-Day Living with ALS and a Feeding Tube
- Author
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Pols, Jeannette and Limburg, Sarah
- Published
- 2016
- Full Text
- View/download PDF
122. How Common is “Non-textbook” Migration in Hudson River Blueback Herring?
- Author
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Limburg, Karin E. and Turner, Sara M.
- Published
- 2016
- Full Text
- View/download PDF
123. Socioeconomic Inequalities in the Utilization of Colorectal Stents for the Treatment of Malignant Bowel Obstruction
- Author
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Okafor, Philip N., Stobaugh, Derrick J., Wong Kee Song, Louis M., Limburg, Paul J., and Talwalkar, Jayant A.
- Published
- 2016
- Full Text
- View/download PDF
124. Association between i.v. thrombolysis volume and door-to-needle times in acute ischemic stroke
- Author
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Groot, Adrien E., van Schaik, Ivo N., Visser, Marieke C., Nederkoorn, Paul J., Limburg, Martien, Aramideh, Majid, de Beer, Frank, Zwetsloot, Caspar P., Halkes, Patricia, de Kruijk, Jelle, Kruyt, Nyika D., van der Meulen, Willem, Spaander, Fianne, van der Ree, Taco, Kwa, Vincent I. H., Van den Berg-Vos, Renske M., Roos, Yvo B., and Coutinho, Jonathan M.
- Published
- 2016
- Full Text
- View/download PDF
125. Juvenile river herring habitat use and marine emigration trends: comparing populations
- Author
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Turner, Sara M. and Limburg, Karin E.
- Published
- 2016
- Full Text
- View/download PDF
126. Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice
- Author
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Schaper, Fleur, van Timmeren, Mirjan M, Petersen, Arjen, Horst, Gerda, Bijl, Marc, Limburg, Pieter C, Westra, Johanna, and Heeringa, Peter
- Published
- 2016
- Full Text
- View/download PDF
127. Life on the bottom: the chemical and morphological asymmetry of winter flounder (Pseudopleuronectes americanus) sagittae
- Author
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Jackman, George, Limburg, Karin E., and Waldman, John
- Published
- 2016
- Full Text
- View/download PDF
128. MT24 Screening and Surveillance Upper Endoscopy Utilization Patterns Among Patients with Gastroesophageal Reflux Disease, Barrett's Esophagus, and Esophageal Neoplasia in the United States
- Author
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Sharma, P, primary, Falk, GW, additional, Bhor, M, additional, Ozbay, AB, additional, Latremouille-Viau, D, additional, Guérin, A, additional, Shi, S, additional, Elvekrog, MM, additional, and Limburg, P, additional
- Published
- 2022
- Full Text
- View/download PDF
129. EE61 Economic Burden of Gastroesophageal Reflux Disease, Barrett's Esophagus, and Esophageal Neoplasia in the United States
- Author
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Sharma, P, primary, Falk, GW, additional, Bhor, M, additional, Ozbay, AB, additional, Latremouille-Viau, D, additional, Guérin, A, additional, Shi, S, additional, Elvekrog, MM, additional, and Limburg, P, additional
- Published
- 2022
- Full Text
- View/download PDF
130. HPR75 Can Multi-Cancer Early Detection Screening Result in Early Cancer Detection? A Modeling Study
- Author
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Chhatwal, J, Xiao, J, Merdan, S, ElHabr, A, Tyson, C, Cao, X, Raoof, S, Fendrick, AM, Ozbay, AB, Limburg, P, Beer, TM, Deshmukh, AA, and Briggs, A
- Published
- 2024
- Full Text
- View/download PDF
131. Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures
- Author
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Georgeson, P, Harrison, TA, Pope, BJ, Zaidi, SH, Qu, C, Steinfelder, RS, Lin, Y, Joo, JE, Mahmood, K, Clendenning, M, Walker, R, Amitay, EL, Berndt, S, Brenner, H, Campbell, PT, Cao, Y, Chan, AT, Chang-Claude, J, Doheny, KF, Drew, DA, Figueiredo, JC, French, AJ, Gallinger, S, Giannakis, M, Giles, GG, Gsur, A, Gunter, MJ, Hoffmeister, M, Hsu, L, Huang, W-Y, Limburg, P, Manson, JE, Moreno, V, Nassir, R, Nowak, JA, Obon-Santacana, M, Ogino, S, Phipps, A, Potter, JD, Schoen, RE, Sun, W, Toland, AE, Trinh, QM, Ugai, T, Macrae, FA, Rosty, C, Hudson, TJ, Jenkins, MA, Thibodeau, SN, Winship, IM, Peters, U, Buchanan, DD, Georgeson, P, Harrison, TA, Pope, BJ, Zaidi, SH, Qu, C, Steinfelder, RS, Lin, Y, Joo, JE, Mahmood, K, Clendenning, M, Walker, R, Amitay, EL, Berndt, S, Brenner, H, Campbell, PT, Cao, Y, Chan, AT, Chang-Claude, J, Doheny, KF, Drew, DA, Figueiredo, JC, French, AJ, Gallinger, S, Giannakis, M, Giles, GG, Gsur, A, Gunter, MJ, Hoffmeister, M, Hsu, L, Huang, W-Y, Limburg, P, Manson, JE, Moreno, V, Nassir, R, Nowak, JA, Obon-Santacana, M, Ogino, S, Phipps, A, Potter, JD, Schoen, RE, Sun, W, Toland, AE, Trinh, QM, Ugai, T, Macrae, FA, Rosty, C, Hudson, TJ, Jenkins, MA, Thibodeau, SN, Winship, IM, Peters, U, and Buchanan, DD
- Abstract
Carriers of germline biallelic pathogenic variants in the MUTYH gene have a high risk of colorectal cancer. We test 5649 colorectal cancers to evaluate the discriminatory potential of a tumor mutational signature specific to MUTYH for identifying biallelic carriers and classifying variants of uncertain clinical significance (VUS). Using a tumor and matched germline targeted multi-gene panel approach, our classifier identifies all biallelic MUTYH carriers and all known non-carriers in an independent test set of 3019 colorectal cancers (accuracy = 100% (95% confidence interval 99.87-100%)). All monoallelic MUTYH carriers are classified with the non-MUTYH carriers. The classifier provides evidence for a pathogenic classification for two VUS and a benign classification for five VUS. Somatic hotspot mutations KRAS p.G12C and PIK3CA p.Q546K are associated with colorectal cancers from biallelic MUTYH carriers compared with non-carriers (p = 2 × 10-23 and p = 6 × 10-11, respectively). Here, we demonstrate the potential application of mutational signatures to tumor sequencing workflows to improve the identification of biallelic MUTYH carriers.
- Published
- 2022
132. Large Americano, Extra Masculine: How People Do Gender at the Coffee House
- Author
-
Aubrey Limburg
- Subjects
Ethnology. Social and cultural anthropology ,GN301-674 - Abstract
This research examines the way in which customers in an urban cafe “do gender.” This research expands existing literature on doing gender in organizational settings by making the customer the focus of the analysis of gender presentations in public spaces. The findings are based on ethnographic research that was conducted over the course of eight weeks in an urban Northwestern city in the United States. My findings suggest that male and female customers most commonly performed hegemonic masculinity and emphasized femininity, respectively. These performances were further pronounced when analyzed in the context of heterosexual relationships, where accountability for gender presentations became even more salient. The way that customers interacted with employees reinforced already normative presentations of gender.
- Published
- 2013
- Full Text
- View/download PDF
133. Variation in Clinical Practice of Intravenous Thrombolysis in Stroke in the Netherlands
- Author
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Auke Bauer, Martien Limburg, and Marieke Christine Visser
- Subjects
Acute stroke ,Thrombolysis ,Quality of care ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
In the Netherlands in 2010, 11% of patients with ischemic stroke received intravenous thrombolysis (IVT), varying from 4 to 26% between hospitals. The aim of this study was to investigate variation in clinical practice and organization of IVT in relationship to performance and outcome. In all 84 Dutch hospitals performing IVT, a stroke neurologist was approached using a web-based survey. The response rate was 82%. The study showed considerable variation. For example, door-to-needle time ranged from 25 to 80 min. High blood pressure was actively lowered before performing IVT by 57% of neurologists, while 35% chose to wait. 28% started IVT without knowledge of laboratory results. Better follow-up data are needed to see whether this variation results in differences in outcome.
- Published
- 2013
- Full Text
- View/download PDF
134. Tracking Fish Lifetime Exposure to Mercury Using Eye Lenses.
- Author
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Miraly, Hadis, Razavi, N. Roxanna, Vogl, Annabelle A., Kraus, Richard T., Gorman, Ann Marie, and Limburg, Karin E.
- Published
- 2023
- Full Text
- View/download PDF
135. Serrated Polyp Yield at Colonoscopy in Patients with Positive FIT, Positive mt-sDNA, and Colonoscopy Only: Data from the New Hampshire Colonoscopy Registry.
- Author
-
Anderson, Joseph C., Hisey, William M., Robinson, Christina M., Limburg, Paul J., Kneedler, Bonny L., and Butterly, Lynn F.
- Abstract
Background: Stool-based screening with fecal immunochemical (FIT) or multitarget-stool DNA (mt-sDNA) tests is associated with increased colonoscopy polyp yield. mt-sDNA includes methylated markers, which improve detection of serrated polyps (SP) versus FIT. We compared SP detection in colonoscopies performed for positive FIT or mt-sDNA tests, as well as in colonoscopies without a preceding stool test, using the New Hampshire Colonoscopy Registry, a comprehensive statewide population-based registry. Methods: Across the three groups, we compared the frequency of clinically relevant SPs (CRSP: sessile SPs, hyperplastic polyps =10 mm, and traditional serrated adenomas). We also compared SP size, histology, number, and bulk (combined sizes). Results: Our sample included 560 mt-sDNA+ (age ± SD: 66.5 ± 7.9), 414 FIT+ (age ± SD: 66.3 ± 8.8), and 59,438 colonoscopy-only patients (age ± SD: 61.7 ± 8.0). mt-sDNA+ patients were more likely to have a higher yield of CRSPs and CRSP bulk than FIT+ (P < 0.0001) or colonoscopy-only patients (P < 0.0001). More mt-sDNA+ patients had CRSPs without large adenomas or colorectal cancers (17.9% vs. 9.9% of FIT+ and 8% of colonoscopy-only patients). After adjusting for synchronous large adenomas, colorectal cancers, and other risk factors, mt-sDNA+ patients were more likely (OR, 1.82; 95% CI, 1.18-2.85) than FIT+ patients to have CRSPs. Conclusions: mt-sDNA+ patients had a higher SP yield than FIT+ or colonoscopy-only patients, particularly in the absence of synchronous large adenomas or colorectal cancer. Impact: Our results suggest that screening with mt-sDNA tests could improve colorectal cancer screening by identifying more patients at increased risk from the serrated pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
136. Niet-herkend hartfalen bij ouderen met kortademigheid
- Author
-
van Riet, Evelien, Hoes, Arno, Limburg, Alexander, Landman, Marcel, van der Hoeven, Henk, and Rutten, Frans
- Published
- 2015
- Full Text
- View/download PDF
137. Schreiben im Zertifikatsprogramm Hochschuldidaktik: Evidenzen und Praxisbeispiele für einen stärkeren Einbezug eines wichtigen Tiefenlerninstruments
- Author
-
Nadine Stahlberg and Anika Limburg
- Subjects
hochschuldidaktisches Zertifikatsprogramm ,Schreiben als Lerninstrument ,Education - Abstract
Durch den Besuch hochschuldidaktischer Zertifikatsprogramme sollen Lehrende beim Erwerb professioneller Lehrkompetenz unterstützt werden. In diesen Programmen wird das Schreiben nicht systematisch berücksichtigt, obwohl es evidenzbasiert wichtigstes Lernmedium ist und wissenschaftliche Schreib- und Textkompetenz für ein erfolgreiches Studium anabdingbar ist. In diesem Beitrag begründen wir, warum das Schreiben einen so hohen Stellenwert hat, dass es in Zertifikatsprogrammen stärker berücksichtigt werden sollte, und wir geben konkrete Anregungen dafür, wie dort Inhalte, Methoden und Konzepte aus Schreibdidaktik und Schreibforschung einbezogen werden können. 09.05.2016 | Nadine Stahlberg (Hamburg) & Anika Limburg (Bochum)
- Published
- 2016
- Full Text
- View/download PDF
138. Transforming research results into useful tools for global health: BOOST
- Author
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Nathan Congdon, Ganesh-Babu Suburaman, Thulasiraj Ravilla, Beatrice Varga, Serge Resnikoff, Joan McLeod, Hugh Taylor, Hans Limburg, Van Lansingh, Elena Schmidt, and Richard LeMesurier
- Subjects
Public aspects of medicine ,RA1-1270 - Published
- 2016
- Full Text
- View/download PDF
139. Unravelling the life history of Amazonian fishes through otolith microchemistry
- Author
-
Theodore W. Hermann, Donald J. Stewart, Karin E. Limburg, and Leandro Castello
- Subjects
otolith microchemistry ,amazon ,life history ,fish migration ,Science - Abstract
Amazonian fishes employ diverse migratory strategies, but the details of these behaviours remain poorly studied despite numerous environmental threats and heavy commercial exploitation of many species. Otolith microchemistry offers a practical, cost-effective means of studying fish life history in such a system. This study employed a multi-method, multi-elemental approach to elucidate the migrations of five Amazonian fishes: two ‘sedentary’ species (Arapaima sp. and Plagioscion squamosissimus), one ‘floodplain migrant’ (Prochilodus nigricans) and two long-distance migratory catfishes (Brachyplatystoma rousseauxii and B. filamentosum). The Sr : Ca and Zn : Ca patterns in Arapaima were consistent with its previously observed sedentary life history, whereas Sr : Ca and Mn : Ca indicated that Plagioscion may migrate among multiple, chemically distinct environments during different life-history stages. Mn : Ca was found to be potentially useful as a marker for identifying Prochilodus's transition from its nursery habitats into black water. Sr : Ca and Ba : Ca suggested that B. rousseauxii resided in the Amazon estuary for the first 1.5–2 years of life, shown by the simultaneous increase/decrease of otolith Sr : Ca/Ba : Ca, respectively. Our results further suggested that B. filamentosum did not enter the estuary during its life history. These results introduce what should be a productive line of research desperately needed to better understand the migrations of these unique and imperilled fishes.
- Published
- 2016
- Full Text
- View/download PDF
140. Prevalence and Clinical Significance of Anti-Lactoferrin Autoantibodies in Inflammatory Bowel Diseases and Primary Sclerosing Cholangitis
- Author
-
Roozendaal, C., Horst, G., Pogány, K., van Milligen de Wit, A. W. M., Kleibeuker, J. H., Haagsma, E. B., Limburg, P. C., Kallenberg, C. G. M., Spik, Geneviève, editor, Legrand, Dominique, editor, Mazurier, Joël, editor, Pierce, Annick, editor, and Perraudin, Jean-Paul, editor
- Published
- 1998
- Full Text
- View/download PDF
141. Assessing the Supply and Demand for Scientists and Technologists in Europe. IES Report 377.
- Author
-
Limburg Univ., Enschede (Netherlands). Research Centre for Education and the Labour Market., Sussex Univ., Brighton (England). Inst. for Employment Studies., Pearson, R., Jagger, N., Connor, H., and Perryman, S.
- Abstract
Available evidence on the supply of and demand for professional scientists and technologists (S&Ts) in the European Union (EU) was reviewed. The main data sources were as follows: approximately 450 reference documents; national and international governments, training and employer bodies, and key international organizations; more than 100 international and national experts from the EU; survey results from 210 research and development establishments from across Europe; and a pilot econometric modeling exercise. The analysis established that the European market for S&Ts is not homogeneous and changing rapidly. More than two-thirds of the EU's approximately 800,000 S&Ts were in Germany, France, and the United Kingdom. The European S&T labor market appeared to be broadening and experiencing continued growth, with more growth occurring in the services sector and small firms. The evidence suggested that demand for S&Ts will continue to develop and fragment. The review documented a need to improve the flexibility and responsiveness of training and methods for forecasting labor supply and demand. (Fifty-three tables/figures and 373 references are included. Information about international classifications and statistical sources, the survey methodology, and pilot modeling of the supply of and demand for research scientists and engineers is appended along with detailed tables by country.) (MN)
- Published
- 2001
142. Send Them Packing: Study Abroad as an Option for Gifted Students.
- Author
-
Limburg-Weber, Lisa
- Abstract
This article describes the benefits of study abroad programs for gifted students. It discusses options available for study abroad programs, the planning process for study abroad programs, deciding where to go and getting there, and tuition and other cost considerations. Key questions for assessing a study abroad program are provided. (Contains references.) (CR)
- Published
- 2000
143. Options for Middle School and Secondary Level Gifted Students.
- Author
-
Olszewski-Kubilius, Paula and Limburg-Weber, Lisa
- Abstract
This article discusses talent development during adolescence, the needs of secondary gifted students, and makes recommendations for gifted programs. Recommendations include providing credit for courses taken outside of school and employing a gifted coordinator. A list of 10 program options for secondary gifted students and their special features is provided. (Contains references.) (CR)
- Published
- 1999
144. Onnodige slechtziendheid onder ouderen in zorginstellingen: lessen uit een interventieproject in de regio Den Bosch
- Author
-
Limburg, J. J., Smith, E. T., van der Horst, F. G., Gruntjes, R. A. G. J. M., Verstraten, P. F. J., Bartels, J. A. M. J., and van Langen, J. M. P.
- Published
- 2014
- Full Text
- View/download PDF
145. Using lot quality-assurance sampling and area sampling to identify priority areas for trachoma control: Viet Nam
- Author
-
Mark Myatt, Nguyen Phuong Mai, Nguyen Quang Quynh, Nguyen Huy Nga, Ha Huy Tai, Nguyen Hung Long, Tran Hung Minh, and Hans Limburg
- Subjects
Tracoma ,Recolección de datos ,Encuestas epidemiológicas ,Estudios transversales ,Muestreo ,Escuelas ,Niño ,Viet Nam ,Public aspects of medicine ,RA1-1270 - Abstract
OBJECTIVE: To report on the use of lot quality-assurance sampling (LQAS) surveys undertaken within an area-sampling framework to identify priority areas for intervention with trachoma control activities in Viet Nam. METHODS: The LQAS survey method for the rapid assessment of the prevalence of active trachoma was adapted for use in Viet Nam with the aim of classifying individual communes by the prevalence of active trachoma among children in primary school. Schoolbased sampling was used; school sites to be sampled were selected using an area-sampling approach. A total of 719 communes in 41 districts in 18 provinces were surveyed. FINDINGS: Survey staff found the LQAS survey method both simple and rapid to use after initial problems with area-sampling methods were identified and remedied. The method yielded a finer spatial resolution of prevalence than had been previously achieved in Viet Nam using semiquantitative rapid assessment surveys and multistage cluster-sampled surveys. CONCLUSION: When used with area-sampling techniques, the LQAS survey method has the potential to form the basis of survey instruments that can be used to efficiently target resources for interventions against active trachoma. With additional work, such methods could provide a generally applicable tool for effective programme planning and for the certification of the elimination of trachoma as a blinding disease.
- Published
- 2005
146. Myocarditis mimicking acute myocardial infarction
- Author
-
van Nierop, J., Limburg, A., and van Ofwegen-Hanekamp, C.E.E.
- Published
- 2015
- Full Text
- View/download PDF
147. Field trial of applicability of lot quality assurance sampling survey method for rapid assessment of prevalence of active trachoma
- Author
-
Myatt Mark, Limburg Hans, Minassian Darwin, and Katyola Damson
- Subjects
Trachoma/epidemiology ,Prevalence ,Quality assurance ,Health care ,Sampling studies ,Validation studies ,Health surveys ,Cnfidence intervals ,Sensitivity and specificity ,Predictive value of tests ,Malawi ,Public aspects of medicine ,RA1-1270 - Abstract
OBJECTIVE: To test the applicability of lot quality assurance sampling (LQAS) for the rapid assessment of the prevalence of active trachoma. METHODS: Prevalence of active trachoma in six communities was found by examining all children aged 2-5 years. Trial surveys were conducted in these communities. A sampling plan appropriate for classifying communities with prevalences 40% was applied to the survey data. Operating characteristic and average sample number curves were plotted, and screening test indices were calculated. The ability of LQAS to provide a three-class classification system was investigated. FINDINGS: Ninety-six trial surveys were conducted. All communities with prevalences 40% were identified correctly. The method discriminated between communities with prevalences 30%, with sensitivity of 98% (95% confidence interval (CI) = 88.2-99.9%), specificity of 84.4% (CI = 69.9-93.0%), positive predictive value of 87.7% (CI = 75.7-94.5%), negative predictive value of 97.4% (CI = 84.9-99.9%), and accuracy of 91.7% (CI = 83.8-96.1%). Agreement between the three prevalence classes and survey classifications was 84.4% (CI = 75.2-90.7%). The time needed to complete the surveys was consistent with the need to complete a survey in one day. CONCLUSION: Lot quality assurance sampling provides a method of classifying communities according to the prevalence of active trachoma. It merits serious consideration as a replacement for the assessment of the prevalence of active trachoma with the currently used trachoma rapid assessment method. It may be extended to provide a multi-class classification method.
- Published
- 2003
148. Antigen-Specific Detection of Autoantibodies Against Myeloperoxidase (MPO) and Proteinase 3 (PR3)
- Author
-
Vanderlocht, J., van Beers, Joyce, Limburg, P. C., Damoiseaux, Jan, Roozendaal, C., Houen, Gunnar, MUMC+: DA CDL Algemeen (9), RS: NUTRIM - R3 - Respiratory & Age-related Health, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Faculteit FHML Centraal, and Med Microbiol, Infect Dis & Infect Prev
- Subjects
030203 arthritis & rheumatology ,0301 basic medicine ,biology ,business.industry ,Autoantibody ,Diagnostic accuracy ,IIf ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Proteinase 3 ,Antigen specific ,IMMUNE FLUORESCENCE ,Myeloperoxidase ,Immunology ,biology.protein ,Medicine ,Small vessel ,cardiovascular diseases ,business - Abstract
ANCA testing was introduced in many laboratories throughout the world when it was recognized that a significant subset of patients with small vessel vasculopathies presented with such antibodies. Many laboratories developed and introduced in-house testing methods for antigen-specific ANCA detection complementary to indirect immune fluorescence screening. Such in-house tests have proven their merit in diagnosing vasculitis and were important to identify critical steps in the development of antigen-specific assays with high sensitivity and specificity. In the meantime various commercial assays became available for antigen-specific ANCA testing. Because of the high diagnostic accuracy of such assays it can be anticipated that commercial, antigen-specific tests will completely replace in-house testing for MPO- and PR3-ANCA. Furthermore, such tests will replace the need for IIF in the diagnostic workup of AAV. In this light it can be foreseen that the knowledge that underlies the development of in-house ANCA testing will gradually disseminate over time. Therefore we describe the current antigen-specific ANCA ELISAs (direct and capture) with the intention to maintain the knowledge and the identification of the critical steps in the development of robust assays.
- Published
- 2019
149. Onnodige slechtziendheid onder ouderen in zorginstellingen: lessen uit een interventieproject in de regio Den Bosch
- Author
-
J. J. Limburg, E. T. Smith, F. G. van der Horst, R. A. G. J. M. Gruntjes, P. F. J. Verstraten, J. A. M. J. Bartels, and J. M. P. van Langen
- Subjects
oogscreening ,ouderen ,slechtziendheid ,vermijdbare blindheid ,zorginstellingen ,zorgketen ,Medicine - Abstract
Introductie Veel ouderen in zorginstellingen in Nederland zijn onnodig blind of slechtziend (visus
- Published
- 2014
- Full Text
- View/download PDF
150. Impact of serum high mobility group box 1 and soluble receptor for advanced glycation end-products on subclinical atherosclerosis in patients with granulomatosis with polyangiitis.
- Author
-
Alexandre W S de Souza, Karina de Leeuw, Mirjan M van Timmeren, Pieter C Limburg, Coen A Stegeman, Marc Bijl, Johanna Westra, and Cees G M Kallenberg
- Subjects
Medicine ,Science - Abstract
The objective of this study was to evaluate whether levels of high mobility group box 1 (HMGB1) in granulomatosis with polyangiitis (GPA) patients are associated with carotid atherosclerosis, related to levels of soluble receptor for advanced glycation end-products (sRAGE) and influenced by immunosuppressive or lipid-lowering therapy. Twenty-three GPA patients and 20 controls were evaluated for HMGB1- and sRAGE levels and for carotid atherosclerosis using ultrasound to determine intima-media thickness (IMT). In vitro the effect of atorvastatin on the production of HMGB1 by lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVEC) was assessed. Serum HMGB1 and sRAGE levels did not differ between patients and controls. A negative correlation was found between sRAGE and maximum IMT but HMGB1 and carotid IMT were not related. HMGB1 levels were reduced in GPA patients on statins and prednisolone. In vitro, atorvastatin reduced HMGB1 levels in supernatants of activated HUVEC. In conclusion, carotid IMT is inversely correlated with sRAGE levels but not with HMGB1 levels. Statins and prednisolone are associated with reduced serum HMGB1 levels and atorvastatin decreases HMGB1 release by activated HUVEC in vitro, indicating an additional anti-inflammatory effect of statins.
- Published
- 2014
- Full Text
- View/download PDF
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