399 results on '"Lin, Chia-Der"'
Search Results
102. Cyr61 increases matrix metalloproteinase‐3 expression and cell motility in human oral squamous cell carcinoma cells
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Chuang, Jing‐Yuan, primary, Yu, Nuo‐Yi, additional, Chiang, I‐Ping, additional, Lai, Chih‐Ho, additional, Lin, Chia‐Der, additional, and Tang, Chih‐Hsin, additional
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- 2012
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103. Improved Candidate Biomarker Detection Based on Mass Spectrometry Data Using the Hilbert-Huang Transform
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Wu, Li-Ching, primary, Hsieh, Ping-Heng, additional, Horng, Jorng-Tzong, additional, Jou, Yu-Jen, additional, Lin, Chia-Der, additional, Cheng, Kuang-Fu, additional, Lin, Cheng-Wen, additional, and Chen, Shih-Yin, additional
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- 2012
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104. Cross-Linguistic Comparison of Frequency-Following Responses to Voice Pitch in American and Chinese Neonates and Adults
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Jeng, Fuh-Cherng, primary, Hu, Jiong, additional, Dickman, Brenda, additional, Montgomery-Reagan, Karen, additional, Tong, Meiling, additional, Wu, Guangqiang, additional, and Lin, Chia-Der, additional
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- 2011
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105. Cholesterol Depletion Reduces Entry of Campylobacter jejuni Cytolethal Distending Toxin and Attenuates Intoxication of Host Cells
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Lin, Chia-Der, primary, Lai, Cheng-Kuo, additional, Lin, Yu-Hsin, additional, Hsieh, Jer-Tsong, additional, Sing, Yu-Ting, additional, Chang, Yun-Chieh, additional, Chen, Kai-Chuan, additional, Wang, Wen-Ching, additional, Su, Hong-Lin, additional, and Lai, Chih-Ho, additional
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- 2011
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106. Association of adenoid hyperplasia and bacterial biofilm formation in children with adenoiditis in Taiwan
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Lin, Chia-Der, primary, Tsai, Mang-Hung, additional, Lin, Cheng-Wen, additional, Ho, Mao-Wang, additional, Wang, Chin-Yuan, additional, Tsou, Yung-An, additional, Kao, Ming-Ching, additional, Tsai, Ming-Hsui, additional, and Lai, Chih-Ho, additional
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- 2011
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107. Exponential modeling of human frequency-following responses to voice pitch
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Jeng, Fuh-Cherng, primary, Chung, Hsiung-Kwang, additional, Lin, Chia-Der, additional, Dickman, Brenda, additional, and Hu, Jiong, additional
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- 2011
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108. Hyperbaric oxygen upregulates cochlear constitutive nitric oxide synthase
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Lin, Chia-Der, primary, Wei, I-Hua, additional, Lai, Chih-Ho, additional, Hsia, Te-Chun, additional, Kao, Ming-Ching, additional, Tsai, Ming-Hsui, additional, Wu, Ching-Hsiang, additional, and Tsai, Mang-Hung, additional
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- 2011
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109. Evaluation of two algorithms for detecting human frequency-following responses to voice pitch
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Jeng, Fuh-Cherng, primary, Hu, Jiong, additional, Dickman, Brenda, additional, Lin, Ching-Yu, additional, Lin, Chia-Der, additional, Wang, Ching-Yuan, additional, Chung, Hsiung-Kwang, additional, and Li, Ximing, additional
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- 2010
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110. Changes in guinea pig cochlea after transient cochlear ischemia
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Lin, Chia-Der, primary, Wei, I-Hua, additional, Tsai, Mang-Hung, additional, Kao, Ming-Ching, additional, Lai, Chih-Ho, additional, Hsu, Chuan-Jen, additional, Oshima, Takeshi, additional, and Tsai, Ming-Hsui, additional
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- 2010
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111. Planar Actuation Hysteresis and Magnetic Switching in Single-Domain Cantilever Beam
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Wei, Zung-Hang, primary, Hsieh, Yi-Ping, additional, Lee, Yun-Ruei, additional, Lin, Chia-Der, additional, Lee, Chiun-Peng, additional, Liao, Chun-Neng, additional, Chen, Ying-Jiun, additional, and Hsu, Chia-Jung, additional
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- 2009
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112. Nosocomial Outbreak of Infection With Multidrug-ResistantAcinetobacter baumanniiin a Medical Center in Taiwan
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Chang, Hui-Lan, primary, Tang, Chih-Hsin, additional, Hsu, Yuan-Man, additional, Wan, Lei, additional, Chang, Ya-Fen, additional, Lin, Chiung-Tsung, additional, Tseng, Yao-Ru, additional, Lin, Ying-Ju, additional, Sheu, Jim Jinn-Chyuan, additional, Lin, Cheng-Wen, additional, Chang, Yun-Chieh, additional, Ho, Mao-Wang, additional, Lin, Chia-Der, additional, Ho, Cheng-Mao, additional, and Lai, Chih-Ho, additional
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- 2009
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113. High Resolution Computed Tomography Analysis of the Temporal Bone
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Chung, Hsiung-Kwang, primary, Wang, Chin-Yuan, additional, Lin, Chia-Der, additional, Lo, Yu-Chien, additional, and Tsai, Ming-Hsui, additional
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- 2008
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114. Ototoxic interaction of kanamycin and 3-nitropropionic acid
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Lin, Chia-Der, primary, Oshima, Takeshi, additional, Oda, Kiyoshi, additional, Yamauchi, Daisuke, additional, Tsai, Ming-Hsui, additional, and Kobayashi, Toshimitsu, additional
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- 2008
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115. R163: Outer Hair Cell Calcium Homeostasis after Noise and Amikacin
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Lin, Chia‐Der, primary, Tan, Ching‐Ting, additional, Lee, Shiann‐Yann, additional, Cheng, Yuan‐Kai Cheng, additional, and Tsai, Ming‐Hsui, additional
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- 2006
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116. R077: Oxidative Stress in Nasal Polyps Allied to Bronchial Type
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Cheng, Yuan‐Kai, primary, Tsai, Ming‐Hsui, additional, Lin, Chia‐Der, additional, Hwang, Guang‐Yuh, additional, Hang, Liang‐Wen, additional, and Chang, Weng‐Cheng, additional
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- 2006
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117. Altered Expression Profile of Superoxide Dismutase Isoforms in Nasal Polyps from Nonallergic Patients
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Cheng, Yuan‐Kai, primary, Hwang, Guang‐Yuh, additional, Lin, Chia‐Der, additional, Tsai, Ming‐Hsui, additional, Tsai, Shih‐We, additional, and Chang, Weng‐Cheng, additional
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- 2006
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118. Measurement of adult vocal fold length
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Su, Mao-Chang, primary, Yeh, Te-Huei, additional, Tan, Ching-Ting, additional, Lin, Chia-Der, additional, Linne, Oan-Che, additional, and Lee, Shiann-Yann, additional
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- 2002
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119. Prognostic Significance of the Proline Form of p53 Codon 72 Polymorphism in Nasopharyngeal Carcinoma
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Tsai, Ming-Hsui, primary, Lin, Chia-Der, additional, Hsieh, Yao-Yuan, additional, Chang, Florence Chi-Chen, additional, Tsai, Fuu-Jen, additional, Chen, Wen-Chi, additional, and Tsai, Chang-Hai, additional
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- 2002
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120. Ventilation Silicone T‐Shaped Tube Insertion
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Lin, Chia‐Der, primary, Tan, Ching‐Ting, additional, Cheng, Yuan‐Kai, additional, and Lee, Shiann‐Yann, additional
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- 2001
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121. Development of Subcortical Pitch Representation in Three-Month-Old Chinese Infants
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Jeng, Fuh-Cherng, Lin, Chia-Der, Chou, Meng-Shih, Hollister, Grant R., Sabol, John T., Mayhugh, Garrett N., Wang, Tang-Chuan, and Wang, Ching-Yuan
- Abstract
This study investigated the development of subcortical pitch processing, as reflected by the scalp-recorded frequency-following response, during early infancy. Thirteen Chinese infants who were born and raised in Mandarin-speaking households were recruited to partake in this study. Through a prospective-longitudinal study design, infants were tested twice: at 1–3 days after birth and at three months of age. A set of four contrastive Mandarin pitch contours were used to elicit frequency-following responses. Frequency Error and Pitch Strength were derived to represent the accuracy and magnitude of the elicited responses. Paired-samples ttests were conducted and demonstrated a significant decrease in Frequency Error and a significant increase in Pitch Strength at three months of age compared to 1–3 days after birth. Results indicated the developmental trajectory of subcortical pitch processing during the first three months of life.
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- 2016
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122. Repeated Colonization by Multi-Drug-Resistant Acinetobacter calcoaceticus-A. baumannii Complex and Changes in Antimicrobial Susceptibilities in Surgical Intensive Care Units.
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Ho, Cheng-Mao, Ho, Mao-Wang, Chi, Chih-Yu, Lin, Chia-Der, Lin, Cheng-Wen, Tseng, Sung-Pin, Teng, Lee-Jene, Chang, Hsiao-Yun, Chang, Hui-Lan, Chang, Ya-Fen, Lin, Hsiu-Hsien, Tien, Ni, Lu, Jang-Jih, and Lai, Chih-Ho
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- 2013
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123. Evaluation of two algorithms for detecting human frequency-following responses to voice pitch.
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Jeng, Fuh-Cherng, Hu, Jiong, Dickman, Brenda, Lin, Ching-Yu, Lin, Chia-Der, Wang, Ching-Yuan, Chung, Hsiung-Kwang, and Li, Ximing
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ALGORITHMS ,MUSICAL perception ,INTONATION (Phonetics) ,REGRESSION analysis ,RESEARCH funding ,HUMAN voice ,RESEARCH methodology evaluation - Abstract
Copyright of International Journal of Audiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2011
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124. Cholesterol Depletion Reduces Entry of Campylobacter jejuniCytolethal Distending Toxin and Attenuates Intoxication of Host Cells
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Lin, Chia-Der, Lai, Cheng-Kuo, Lin, Yu-Hsin, Hsieh, Jer-Tsong, Sing, Yu-Ting, Chang, Yun-Chieh, Chen, Kai-Chuan, Wang, Wen-Ching, Su, Hong-Lin, and Lai, Chih-Ho
- Abstract
ABSTRACTCampylobacter jejuniis a common cause of pediatric diarrhea worldwide. Cytolethal distending toxin, produced by Campylobacter jejuni, is a putative virulence factor that induces cell cycle arrest and apoptosis in eukaryotic cells. Cellular cholesterol, a major component of lipid rafts, has a pivotal role in regulating signaling transduction and protein trafficking as well as pathogen internalization. In this study, we demonstrated that cell intoxication by Campylobacter jejunicytolethal distending toxin is through the association of cytolethal distending toxin subunits and membrane cholesterol-rich microdomains. Cytolethal distending toxin subunits cofractionated with detergent-resistant membranes, while the distribution reduced upon the depletion of cholesterol, suggesting that cytolethal distending toxin subunits are associated with lipid rafts. The disruption of cholesterol using methyl-β-cyclodextrin not only reduced the binding activity of cytolethal distending toxin subunits on the cell membrane but also impaired their delivery and attenuated toxin-induced cell cycle arrest. Accordingly, cell intoxication by cytolethal distending toxin was restored by cholesterol replenishment. These findings suggest that membrane cholesterol plays a critical role in the Campylobacter jejunicytolethal distending toxin-induced pathogenesis of host cells.
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- 2011
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125. Nosocomial Outbreak of Infection With Multidrug-Resistant Acinetobacter baumanniiin a Medical Center in Taiwan
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Chang, Hui-Lan, Tang, Chih-Hsin, Hsu, Yuan-Man, Wan, Lei, Chang, Ya-Fen, Lin, Chiung-Tsung, Tseng, Yao-Ru, Lin, Ying-Ju, Sheu, Jim Jinn-Chyuan, Lin, Cheng-Wen, Chang, Yun-Chieh, Ho, Mao-Wang, Lin, Chia-Der, Ho, Cheng-Mao, and Lai, Chih-Ho
- Abstract
Objective.To investigate a nosocomial outbreak of infection with multidrug-resistant (MDR) Acinetobacter baumanniiin the intensive care units at China Medical University Hospital in Taiwan.Design.Prospective outbreak investigation.Setting.Three intensive care units in a 2,000-bed university hospital in Taichung, Taiwan.Methods.Thirty-eight stable patients in 3 intensive care units, all of whom had undergone an invasive procedure, were enrolled in our study. Ninety-four A. baumanniistrains were isolated from the patients or the environment in the 3 intensive care units, during the period from January 1 through December 31, 2006. We characterized A. baumanniiisolates by use of repetitive extragenic palindromic–polymerase chain reaction (REP-PCR) and random amplified polymorphic DNA (RAPD) fingerprinting. The clinical characteristics of the source patients and the environment were noted.Results.All of the clinical isolates were determined to belong to the same epidemic strain of MDR A. baumanniiby the use of antimicrobial susceptibility tests, REP-PCR, and RAPD fingerprinting. All patients involved in the infection outbreak had undergone an invasive procedure. The outbreak strain was also isolated from the environment and the equipment in the intensive care units. Moreover, an environmental survey of one of the intensive care units found that both the patients and the environment harbored the same outbreak strain.Conclusion.The outbreak strain of A. baumanniimight have been transmitted among medical staff and administration equipment. Routine and aggressive environmental and equipment disinfection is essential for preventing recurrent outbreaks of nosocomial infection with MDR A. baumannii.
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- 2009
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126. Chronic rhinosinusitis and premorbid autoimmune diseases: a population-based case–control study.
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Shih, Liang-Chun, Hsieh, Hua-Hsin, Tsay, Gregory J., Lee, Ivan T., Tsou, Yung-An, Lin, Cheng-Li, Shen, Te-Chun, Bau, Da-Tian, Tai, Chih-Jaan, Lin, Chia-Der, and Tsai, Ming-Hsui
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SINUSITIS ,AUTOIMMUNE diseases ,GENDER ,LOGISTIC regression analysis ,NATIONAL health insurance - Abstract
Evidence shows that chronic rhinosinusitis (CRS) is associated with prior presence of autoimmune diseases; however, large-scale population-based studies in the literature are limited. We conducted a population-based case–control study investigating the association between CRS and premorbid autoimmune diseases by using the National Health Insurance Research Database in Taiwan. The CRS group included adult patients newly diagnosed with CRS between 2001 and 2013. The date of diagnosis was defined as the index date. The comparison group included individuals without CRS, with 1:4 frequency matching for gender, age, and index year. Premorbid diseases were forward traced to 1996. Univariate and multivariate logistic regression was performed to estimate odds ratios (ORs) and 95% confidence intervals. The CRS group consisted of 30,611 patients, and the comparison group consisted of 122,444 individuals. Patients with CRS had a higher significant association with premorbid autoimmune diseases (adjusted OR 1.39 [1.28–1.50]). Specifically, patients with CRS had a higher significant association with ankylosing spondylitis, polymyositis, psoriasis, rheumatoid arthritis, sicca syndrome, and systemic lupus erythematosus (adjusted OR 1.49 [1.34–1.67], 3.47 [1.12–10.8], 1.22 [1.04–1.43], 1.60 [1.31–1.96], 2.10 [1.63–2.72], and 1.69 [1.26–2.25]). In subgroup analysis, CRS with and without nasal polyps demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 1.34 [1.14–1.58] and 1.50 [1.38–1.62]). In addition, CRS with fungal and non-fungal infections also demonstrated a significant association with premorbid autoimmune diseases (adjusted OR 2.02 [1.72–2.49] and 1.39 [1.28–1.51]). In conclusion, a significant association between CRS and premorbid autoimmune diseases has been identified. These underlying mechanisms need further investigation. [ABSTRACT FROM AUTHOR]
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- 2020
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127. ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.
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Lee, Ivan T., Nakayama, Tsuguhisa, Wu, Chien-Ting, Goltsev, Yury, Jiang, Sizun, Gall, Phillip A., Liao, Chun-Kang, Shih, Liang-Chun, Schürch, Christian M., McIlwain, David R., Chu, Pauline, Borchard, Nicole A., Zarabanda, David, Dholakia, Sachi S., Yang, Angela, Kim, Dayoung, Chen, Han, Kanie, Tomoharu, Lin, Chia-Der, and Tsai, Ming-Hsui
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ACE inhibitors ,ANGIOTENSIN-receptor blockers ,SARS-CoV-2 ,CILIA & ciliary motion ,COVID-19 pandemic ,PATHOLOGY ,ANGIOTENSIN converting enzyme - Abstract
The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the pathogenesis of SARS-CoV-2. We investigate the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of human donors using a diverse panel of banked tissues. Here, we report our discovery that the ACE2 receptor protein robustly localizes within the motile cilia of airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during host respiratory transmission. We further determine whether ciliary ACE2 expression in the upper airway is influenced by patient demographics, clinical characteristics, comorbidities, or medication use, and show the first mechanistic evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) does not increase susceptibility to SARS-CoV-2 infection through enhancing the expression of ciliary ACE2 receptor. These findings are crucial to our understanding of the transmission of SARS-CoV-2 for prevention and control of this virulent pathogen. Understanding how SARS-CoV-2 gains initial entry into the human body is a key step towards the development of prophylaxes and therapeutics for COVID-19. Here, the authors show that ACE2, the receptor for SARS-CoV-2, is abundantly expressed in the motile cilia of the human nasal and respiratory tract and is not affected by the use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. [ABSTRACT FROM AUTHOR]
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- 2020
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128. Increased risk of hearing loss associated with MT-RNR1 gene mutations: a real-world investigation among Han Taiwanese Population.
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Chen, Hou-Kuang, Hsieh, Yow-Wen, Hsu, Hsing-Yu, Liu, Ting-Yuan, Zhang, Yu-Ting, Lin, Chia-Der, and Tsai, Fuu-Jen
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TAIWANESE people , *HEARING disorders , *LEBER'S hereditary optic atrophy , *GENETIC mutation , *SENSORINEURAL hearing loss , *PROPORTIONAL hazards models - Abstract
Background: Previous studies have implicated inherited mutations in mitochondrial DNA (mtDNA) in sensorineural hearing loss (SNHL). However, the definitive association between mitochondrial 12S rRNA (MT-RNR1) variants and hearing loss in the population has not been well established, particularly in Asia. The objective of this retrospective cohort study was to assess the association between MT-RNR1 variants and the risk of SNHL in patients in Taiwan. Methods: The cohort included 306,068 participants from Taiwan between January 2003 and December 2020. Participants were classified based on genetic variants, particularly mitochondrial mutations (rs267606618, rs267606619, rs267606617). MT-RNR1 variant cases were matched 1:10 with non-mutant patients by age, gender, and visit year, excluding those with pre-existing hearing loss. The primary endpoint was SNHL, identified using specific ICD-TM codes with a 90% positive predictive value. Medication exposure history was determined via self-report or electronic medical records in the hospital. Cox proportional hazard regression models were used to assess the association between MT-RNR1 variants and hearing loss, adjusting for various covariates. Kaplan-Meier survival curves and log-rank tests compared hearing loss incidence between groups. Results: The mean age of the mtDNA variants group is 32.4 years, with a standard deviation of 19.2 years. The incidence density of hearing loss for the mutation group was 36.42 per 10,000 person-years (95% Confidence Interval [CI], 27.21–47.73), which was higher than the 23.77per 10,000 person-years (95% CI, 21.32–26.42) in the wild-type group (p = 0.0036). Additionally, diabetes mellitus was associated with an increased risk of developing SNHL in individuals with MT-RNR1 variants (adjusted hazard ratio = 1.76 [95% CI, 1.00-3.09], p < 0.05). Conclusion: This study highlights the increased risk of hearing loss in patients carrying MT-RNR1 variants, particularly those with diabetes mellitus. Future research that integrates genetic and clinical data is crucial for developing more precise interventions to monitor and treat hearing loss in this vulnerable population. [ABSTRACT FROM AUTHOR]
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- 2024
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129. Clinical Outcomes of Severe Rhinosinusitis Complicated with Cavernous Sinus Syndrome.
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Lin, Jin-Yi, Liu, Chien-Lin, Dai, Zheng-Yan, Li, Yu-Ting, Tsou, Yung-An, Lin, Chia-Der, Tai, Chih-Jaan, and Shih, Liang-Chun
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CAVERNOUS sinus , *SINUSITIS , *TREATMENT effectiveness , *SYMPTOMS , *BRAIN abscess , *SPHENOID sinus - Abstract
Background: Various diseases involving the cavernous sinus can cause a condition called cavernous sinus syndrome (CSS), which is characterized by ophthalmoplegia or sensory deficits over the face resulting from the compression effect of internal structure. While tumor compression is the most reported cause of CSS, statistical data on CSS caused by infections are limited. Its risk factors, treatment methods, and clinical outcomes are not well-documented. Methods: In this retrospective study, we reviewed the data of patients admitted to a tertiary medical center from 2015 to 2022 with a diagnosis of acute and chronic sinusitis and at least one diagnostic code for CSS symptoms. We manually reviewed whether patients were involved in two or more of the following cranial nerves (CN): CN III, CN IV, CN V, or CN VI, or at least one of these nerves with a neuroimaging-confirmed lesion in the cavernous sinus. Results: Nine patients were diagnosed with rhinosinusitis-related CSS. The most common comorbidity was type 2 diabetes, and the most common clinical manifestations were diplopia and blurred vision. The sphenoid sinus was the most affected sinus. One patient expired due to a severe brain abscess infection without surgery. The remaining patients underwent functional endoscopic sinus surgery, and 50% of the pathology reports indicated fungal infections. Staphylococcus spp. was the most cultured bacteria, and Amoxycillin/Clavulanate was the most used antibiotic. Only four patients had total recovery during the follow-up one year later. Conclusions: CSS is a rare but serious complication of rhinosinusitis. Patients with diabetes and the elderly may be at a higher risk for this complication. Even after treatment, some patients may still have neurological symptoms. [ABSTRACT FROM AUTHOR]
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- 2024
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130. Mycobacterial Infection in Recalcitrant Otomastoiditis: A Case Series and Literature Review.
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Tsai, Tammy, Lan, Wei-Che, Mao, Jit-Swen, Lee, Yu-Chien, Tsou, Yung-An, Lin, Chia-Der, Shih, Liang-Chun, and Wang, Ching-Yuan
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MYCOBACTERIAL diseases , *LITERATURE reviews , *OTITIS media , *SYMPTOMS , *TUBERCULOSIS , *TISSUE culture - Abstract
Otomastoiditis caused by mycobacterial infections is uncommon and recalcitrant. Its clinical presentations, sometimes similar to those of common chronic suppurative otitis media, make diagnosis difficult. This retrospective study analyzed the clinical features, treatment course, and therapeutic outcomes of patients with mycobacterial otomastoiditis. The cases of six patients diagnosed with mycobacterial otomastoiditis or suspected mycobacterial infection between January 2007 and January 2019 in a single tertiary medical center in Taiwan were investigated. Information about predisposing factors, clinical features, culture reports, histopathology, treatment course, and outcomes were collected and analyzed. Relevant literature available in English was also reviewed. One patient was infected with tuberculous mycobacteria, two with suspected tuberculous mycobacteria, and three with nontuberculous mycobacteria. All six patients responded poorly to empiric antibiotic therapy, and diagnosis was not possible at their previous clinics. Five patients underwent tympanomastoidectomies; one was administered antimycobacterial medication without undergoing surgery. Mycobacterial infection was confirmed from a tissue culture or from the histopathology of the specimen, but in two patients, no definitive evidence of tuberculosis was found. Antimycobacterial medication was administered based on clinical suspicion, and improvement was noted. With appropriate therapy, all patients recovered, and no sequelae were observed after treatment. If empiric antibiotic therapy cannot achieve acceptable results, atypical infections, such as mycobacteria, should be considered. Antimycobacterial medication could be administered under clinical suspicion, serving as a diagnosis ex juvantibus. Surgical intervention might help reduce the bacterial load and obtain specimens for accurate diagnosis, but this may be unnecessary if appropriate antimycobacterial medication results in improvement. Early diagnosis and treatment can prevent complications in patients with recalcitrant otomastoiditis. [ABSTRACT FROM AUTHOR]
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- 2023
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131. Clinical feature‐based diagnosis criteria of eosinophil and non‐eosinophil chronic rhinosinusitis in Taiwan.
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Ma, Jia‐Hung, Hsieh, Bing‐Han, Huang, Shuang‐Shuang, Li, Yu‐Ting, Tsou, Yung‐An, Lin, Chia‐Der, Tai, Chih‐Jaan, and Shih, Liang‐Chun
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EOSINOPHILS , *RECEIVER operating characteristic curves , *EOSINOPHILIA , *SINUSITIS , *NASAL polyps - Abstract
Background: The prevalence of eosinophilic chronic rhinosinusitis (ECRS) has increased in Taiwan with a higher recurrence rate of nasal polyps after surgery. Therefore, we aimed to formulate the pre‐operative diagnostic criteria for patients with ECRS in Taiwan. Methods: This case–control study included patients diagnosed with CRS with nasal polyps (CRSwNP) who underwent functional endoscopic sinus surgery (FESS) at a tertiary hospital in Taiwan. The patients were classified into ECRS and non‐eosinophilic CRS (NECRS) groups based on their histopathology. Demographic data, symptom severity scores, and computed tomography findings of the two groups were analyzed. We utilized receiver operating characteristic curve (ROC) analysis to evaluate parameters that could predict the diagnosis of ECRS. Results: Total 408 CRSwNP patients were enrolled (ECRS group: 163; NECRS group: 245). ECRS group was strongly associated with asthma (6.1% vs. 2.0%, p =.03), higher blood eosinophil counts (4.3% vs. 2.7%, p <.01), higher serum IgE (285.3 vs. 50.2 IU/mL, p =.02), and higher 22‐item Sino‐Nasal Outcome Test (SNOT‐22) score (40.5 vs. 36.7, p =.03). The ECRS criteria based on ROC curve included the SNOT‐22 (>45, 2 points), serum eosinophil count percentage (>4%, 4 points), asthma (4 points), total serum IgE (>140 IU/mL, 4 points), Lund–Mackay score (>9.5, 4 points), and ethmoid‐to‐maxillary opacification ratio on CT (>1.5, 5 points). The cutoff score was 14 points (sensitivity, 70.2%; specificity, 93.3%). Conclusions: Clinical‐feature‐based criteria may predict the diagnosis of ECRS before FESS in Taiwan. Level of Evidence: Level 3. Our ECRS criteria based on the ROC curve included the SNOT‐22 (>45, 2 points), serum eosinophil count percentage (>4%, 4 points), asthma (4 points), total serum IgE (>140 IU/mL, 4 points), Lund–Mackay score (>9.5, 4 points), and ethmoid‐to‐maxillary opacification ratio on CT (>1.5, 5 points) (Table 4). The cutoff score was 14 points (sensitivity, 70.2%; specificity, 93.3%). This clinical‐feature‐based criterion may predict the diagnosis of ECRS before FESS in Taiwan. Precise information and shared decision‐making may be provided to the patient prior to surgery. [ABSTRACT FROM AUTHOR]
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- 2023
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132. Inverse association of β-lactam-resistant Haemophilus influenzaewith adenoid biofilm formation in patients with adenoidectomy surgery
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Tsou, Yung-An, Lin, Chia-Der, Hsu, Hui-Ying, Tsai, Ming-Hsui, and Lai, Chih-Ho
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- 2015
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133. Association between angiotensin receptor blockers and suicide: nationwide population-based propensity score matching study.
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Lin, Shih-Yi, Lin, Cheng-Li, Lin, Cheng-Chieh, Hsu, Wu-Huei, Lin, Chia-Der, Wang, I-Kuan, Hsieh, Ming-Han, Hsu, Chung-Y., and Kao, Chia-Hung
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ANGIOTENSIN receptors , *PROPENSITY score matching , *ATTEMPTED suicide , *SUICIDE , *LOG-rank test , *RESEARCH , *RESEARCH methodology , *ACE inhibitors , *RETROSPECTIVE studies , *EVALUATION research , *MEDICAL cooperation , *COMPARATIVE studies , *PROBABILITY theory , *LONGITUDINAL method - Abstract
Background: Angiotensin receptor blockers (ARBs) have been reported to ameliorate anxiety and mood disorders in animal models. Cohort links between ARB use and suicide risk in humans require clarification.Methods: Data were obtained from the National Health Insurance Research Database. Patients diagnosed as having hypertension according to the criteria of the International Classification of Diseases, Ninth Revision, Clinical Modification (401-405) from January 1, 2000 to December 31, 2012 were enrolled as the target population. We defined enrollees who had received ARB prescriptions for at least 28 days as ARB users. Those who had never taken ARB prior or during the study period were defined as ARB nonusers and were propensity score-matched with ARB users. The end outcome was confirmation of a suicide attempt.Results: After propensity score matching was conducted, 40,976 ARB users and 40,976 nonusers were selected as the matched cohorts. The overall incidence rate of suicide attempt was significantly lower in ARB users than in nonusers (0.51 vs. 1.07 per 10,000 person-years; adjusted hazard ratio = 0.48, 95% confidence interval = 0.26-0.87). A Kaplan-Meier survival analysis with a log-rank test revealed a lower cumulative incidence of suicide attempt in ARB users than in nonusers (p < 0.001 for the unmatched cohort; p = 0.01 for the matched cohort).Conclusions: ARB use was not associated with an increased risk for suicide compared with non-ARB use. [ABSTRACT FROM AUTHOR]- Published
- 2020
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134. Association between exposure to road traffic noise and hearing impairment: a case-control study.
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Wang, Tang-Chuan, Chang, Ta-Yuan, Tyler, Richard S., Hwang, Bing-Fang, Chen, Yi-Hung, Wu, Che-Ming, Liu, Chiu-Shong, Chen, Kuang-Chao, Lin, Chia-Der, and Tsai, Ming-Hsui
- Abstract
Purpose: Noise pollution in urban areas is increasing steadily, and the study of road traffic noises and their effects on the auditory system was rare. This study investigated the potential effects of road traffic noise on auditory systems and hearing.A case-control study recruited outpatients from the Otolaryngology department. The case group (
n = 41) had binaural hearing loss (HL) of standard pure-tone average(PTA) ≥ 25 dB or high frequency PTA ≥ 25 dB, while the control group (n = 39) had binaural hearing level of any frequency < 25 dB. Detailed otologic evaluations were performed. Between-group data were evaluated using logistic regression analysis. Case or control group was identified based on the audiogram.A total of 80 subjects were recruited, including 41 with hearing impairment and 39 as control. The mean exposure level of road traffic noise was significantly higher in the case group than the control group (p = 0.005). A crude OR of 5.78 showed an increased risk of greater than 70 dB of road traffic noise on hearing impairment and tinnitus (p < 0.001). The aOR of 9.24 (p = 0.002) from a multiple variate analysis suggested that road traffic noise levels greater than 70 dB may have a damaging effect on hearing. Damaging effects on hearing persisted even after adjusting for confounders in the full multivariate model (aOR of 9.24 [95% CI: 2.198–38.869];p = 0.002).Exposing to road traffic noise greater than 70 dB showed an increased risk of damage to the auditory system. These results might help public health administrators and physicians to develop programs that address the health dangers of noise.Methods: Noise pollution in urban areas is increasing steadily, and the study of road traffic noises and their effects on the auditory system was rare. This study investigated the potential effects of road traffic noise on auditory systems and hearing.A case-control study recruited outpatients from the Otolaryngology department. The case group (n = 41) had binaural hearing loss (HL) of standard pure-tone average(PTA) ≥ 25 dB or high frequency PTA ≥ 25 dB, while the control group (n = 39) had binaural hearing level of any frequency < 25 dB. Detailed otologic evaluations were performed. Between-group data were evaluated using logistic regression analysis. Case or control group was identified based on the audiogram.A total of 80 subjects were recruited, including 41 with hearing impairment and 39 as control. The mean exposure level of road traffic noise was significantly higher in the case group than the control group (p = 0.005). A crude OR of 5.78 showed an increased risk of greater than 70 dB of road traffic noise on hearing impairment and tinnitus (p < 0.001). The aOR of 9.24 (p = 0.002) from a multiple variate analysis suggested that road traffic noise levels greater than 70 dB may have a damaging effect on hearing. Damaging effects on hearing persisted even after adjusting for confounders in the full multivariate model (aOR of 9.24 [95% CI: 2.198–38.869];p = 0.002).Exposing to road traffic noise greater than 70 dB showed an increased risk of damage to the auditory system. These results might help public health administrators and physicians to develop programs that address the health dangers of noise.Results: Noise pollution in urban areas is increasing steadily, and the study of road traffic noises and their effects on the auditory system was rare. This study investigated the potential effects of road traffic noise on auditory systems and hearing.A case-control study recruited outpatients from the Otolaryngology department. The case group (n = 41) had binaural hearing loss (HL) of standard pure-tone average(PTA) ≥ 25 dB or high frequency PTA ≥ 25 dB, while the control group (n = 39) had binaural hearing level of any frequency < 25 dB. Detailed otologic evaluations were performed. Between-group data were evaluated using logistic regression analysis. Case or control group was identified based on the audiogram.A total of 80 subjects were recruited, including 41 with hearing impairment and 39 as control. The mean exposure level of road traffic noise was significantly higher in the case group than the control group (p = 0.005). A crude OR of 5.78 showed an increased risk of greater than 70 dB of road traffic noise on hearing impairment and tinnitus (p < 0.001). The aOR of 9.24 (p = 0.002) from a multiple variate analysis suggested that road traffic noise levels greater than 70 dB may have a damaging effect on hearing. Damaging effects on hearing persisted even after adjusting for confounders in the full multivariate model (aOR of 9.24 [95% CI: 2.198–38.869];p = 0.002).Exposing to road traffic noise greater than 70 dB showed an increased risk of damage to the auditory system. These results might help public health administrators and physicians to develop programs that address the health dangers of noise.Conclusions: Noise pollution in urban areas is increasing steadily, and the study of road traffic noises and their effects on the auditory system was rare. This study investigated the potential effects of road traffic noise on auditory systems and hearing.A case-control study recruited outpatients from the Otolaryngology department. The case group (n = 41) had binaural hearing loss (HL) of standard pure-tone average(PTA) ≥ 25 dB or high frequency PTA ≥ 25 dB, while the control group (n = 39) had binaural hearing level of any frequency < 25 dB. Detailed otologic evaluations were performed. Between-group data were evaluated using logistic regression analysis. Case or control group was identified based on the audiogram.A total of 80 subjects were recruited, including 41 with hearing impairment and 39 as control. The mean exposure level of road traffic noise was significantly higher in the case group than the control group (p = 0.005). A crude OR of 5.78 showed an increased risk of greater than 70 dB of road traffic noise on hearing impairment and tinnitus (p < 0.001). The aOR of 9.24 (p = 0.002) from a multiple variate analysis suggested that road traffic noise levels greater than 70 dB may have a damaging effect on hearing. Damaging effects on hearing persisted even after adjusting for confounders in the full multivariate model (aOR of 9.24 [95% CI: 2.198–38.869];p = 0.002).Exposing to road traffic noise greater than 70 dB showed an increased risk of damage to the auditory system. These results might help public health administrators and physicians to develop programs that address the health dangers of noise. [ABSTRACT FROM AUTHOR]- Published
- 2021
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135. Increased risks of retinal vascular occlusion in patients with migraine and the protective effects of migraine treatment: a population-based retrospective cohort study.
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Ho KY, Lin CD, Hsu TJ, Huang YH, Tsai FJ, and Liang CY
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- Humans, Male, Female, Adult, Middle Aged, Retrospective Studies, Taiwan epidemiology, Risk Factors, Incidence, Aged, Databases, Factual, Proportional Hazards Models, Young Adult, Migraine Disorders drug therapy, Migraine Disorders complications, Retinal Vein Occlusion drug therapy, Retinal Vein Occlusion epidemiology, Retinal Vein Occlusion complications, Retinal Artery Occlusion epidemiology
- Abstract
Associations between migraine and retinal vascular occlusion have been reported, but there is no large-scale and comprehensive study. Therefore, we aimed to determine risks of retinal vascular occlusion in patients with migraine. Using the Taiwan National Health Insurance Research Database from 2009 to 2020, we enrolled 628,760 patients with migraine and 628,760 matched individuals without migraine. Study outcomes were diagnoses of retinal vascular occlusion, including retinal artery occlusion (RAO) and retinal vein occlusion (RVO). Adjusted hazard ratio (aHR) of retinal vascular occlusion related to migraine was estimated. The cumulative incidences of subsequent retinal vascular occlusion, RAO, and RVO were significantly higher in migraine patients compared with controls (0.31% vs. 0.21%; 0.09% vs. 0.05%; 0.22% vs. 0.17%; all p < 0.001). The hazards of retinal vascular occlusion, RAO, and RVO were significantly greater in the migraine group (aHR, 1.69 [95% CI, 1.57, 1.83], 2.13 [95% CI, 1.84, 2.48] and 1.53 [95% CI, 1.40, 1.68], respectively). Risks of retinal vascular occlusion were significantly higher in migraine both with aura (MA) and without aura (MO) (aHR, 1.77 [95% CI, 1.58, 1.98], and 1.92 [95% CI, 1.64, 2.25]). Among patients with migraine, nonsteroidal anti-inflammatory drugs, propranolol, and flunarizine significantly reduce their risks of retinal vascular occlusion (aHR, 0.19 [95% CI, 0.16, 0.22], 0.73 [95% CI, 0.62, 0.86], 0.84 [95% CI, 0.76, 0.93]). Migraine, MA and MO are independently associated with higher risks of retinal vascular occlusion, RAO, and RVO., (© 2024. The Author(s).)
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- 2024
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136. Efficacy of Adjuvant Sublingual Immunotherapy After Septomeatoplasty.
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Hsieh BH, Kuo YC, Yong SB, Tien HC, Hsu CC, Hsu CL, Tsou YA, Lin CD, Tai CJ, Wang JY, and Shih LC
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- Humans, Male, Female, Adult, Treatment Outcome, Nasal Septum surgery, Middle Aged, Young Adult, Taiwan, Animals, Turbinates surgery, Combined Modality Therapy, Hypertrophy, Sublingual Immunotherapy methods, Rhinitis, Allergic therapy
- Abstract
Background: The efficacy of adjuvant sublingual immunotherapy (SLIT) in correcting structural problems in patients with allergic rhinitis (AR) caused by mite who have undergone septomeatoplasty (SMP) has not been studied., Methods: This non-randomized controlled study recruited patients with AR (caused by mite) and concurrent septal deviation and inferior turbinate hypertrophy, at a tertiary hospital in Taiwan. SMP was performed on all patients as a surgical intervention. The patients were then divided into two groups: the control group, which underwent surgery only, and the experimental group, which received SLIT as an adjuvant treatment. Demographic data and rhinitis control assessment test (RCAT) results were analyzed., Results: A total of 96 patients were enrolled in the study (SMP + SLIT group, n = 52; SMP only group, n = 44). No significant differences were observed in any of the variables between the two groups before and one month after surgery. However, during evaluations at the third and sixth month, the SMP + SLIT group showed significant improvement in the total RCAT scores compared to the SMP only group (28.6 ± 1.56 vs. 24.5 ± 3.66, p < 0.001; 27.1 ± 2.87 vs. 19.9 ± 5.56, p < 0.001). In addition, significantly better control of all RCAT sub-categories was observed in the SMP + SLIT group at the third and sixth month evaluations., Conclusions: SLIT may serve as an ideal adjuvant therapy after SMP in patients with AR., Level of Evidence: 3 Laryngoscope, 134:3073-3079, 2024., (© 2024 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2024
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137. Effects of grit on medical students' wellbeing during clerkships: a longitudinal observational cohort study.
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Lin YK, Lin CD, Chen DY, and Lin BY
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Introduction: In medical education, the clerkship phase is a demanding period during which medical students learn to navigate the responsibilities of medical school and clinical medicine. Grit, a personal quality regarded as a non-cognitive trait, refers to perseverance and passion; specifically, it represents the ability to endure hardship and work industriously toward a goal. Most studies analysed grit as a single concept and few studies have investigated the effect of grit on the well-being of medical students through the whole-specialty training (i.e. surgical and non-surgical specialty rotations) required in clinical clerkships. Therefore, this study investigated whether associations exist between medical students' grit, measured by the two subconstructs of perseverance and passion, and their well-being during clerkships in surgical and non-surgical specialty units., Methods: This one-year prospective web-based questionnaire study enrolled fifth-year medical students at a tertiary medical centre in central Taiwan between September 2017 and July 2018 in their first-year clerkship. The students' sex, age, and grit were measured at the start of their clerkship. Routine surveys were conducted over one year to assess burnout and compassion satisfaction for students' well-being, and the training specialty characteristics of the surgical and non-surgical specialty departments were recorded. This study included 92 medical students and 1,055 survey responses from individual specialty rotations. Descriptive, univariate and multivariate analyses were performed., Results: Our results revealed that medical students' perseverance, as part of grit, was related to lower burnout and higher compassion satisfaction during clerkships, but not the subconstruct of passion. Moreover, the positive trait of perseverance measured in our study had greater explanatory power for compassion satisfaction than for burnout. Furthermore, the results revealed that older medical students suffered from less burnout than their younger counterparts, and that male medical students expressed higher compassion satisfaction than their female counterparts., Discussion: Perseverance, as a subconstruct of grit, is a positive personal quality for medical students' clerkships, and methods driving the cultivation of perseverance in medical education should be considered. In addition, even though positive traits such as perseverance equipped medical students for compassion satisfaction, additional factors attributed to medical students' burnout must be identified., Competing Interests: The authors declare that this study was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest., (Copyright © 2024 Lin, Lin, Chen and Lin.)
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- 2024
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138. Impact of occupational noise exposure on the hearing level in hospital staffs: a longitudinal study.
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Wang TC, Yu YC, Hsu A, Lin JY, Tsou YA, Liu CS, Chuang KJ, Pan WC, Yang CA, Hu SL, Ho CY, Chen TL, Lin CD, Pai PY, and Chang TY
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- Humans, Longitudinal Studies, Personnel, Hospital, Hearing, Noise, Occupational adverse effects, Hearing Loss, Noise-Induced epidemiology, Occupational Exposure, Occupational Diseases
- Abstract
The study aimed to evaluate the impact of occupational noise on hearing loss among healthcare workers using audiometry. A longitudinal study was conducted with a six-month follow-up period in a hospital with 21 participants, divided into high-noise-exposure (HNE) and low-noise-exposure (LNE) groups. Mean noise levels were higher in the HNE group (70.4 ± 4.5 dBA), and hearing loss was measured using pure-tone audiometry at baseline and follow-up. The HNE group had significantly higher mean threshold levels at frequencies of 0.25 kHz, 0.5 kHz, 4.0 kHz, and an average of 0.5, 1, 2, and 4 kHz (all p-values < 0.05) after the follow-up period. After adjusting for confounding factors, the HNE group had significantly higher hearing loss levels at 0.25 kHz, 0.5 kHz, and average frequencies of 0.5, 1, 2, and 4 kHz compared to the LNE group at the second measurement. Occupational noise levels above 65 dBA over six months were found to cause significant threshold changes at frequencies of 0.25 kHz, 0.5 kHz, and an average of 0.5-4.0 kHz. This study highlights the risk of noise-induced hearing loss among healthcare workers and emphasizes the importance of implementing effective hearing conservation programs in the workplace. Regular monitoring and assessment of noise levels and hearing ability, along with proper use of personal protective equipment, are crucial steps in mitigating the impact of occupational noise exposure on the hearing health of healthcare workers., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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139. Adult-onset congenital cholesteatoma in the hypotympanum initially presenting as Bell's palsy: A case report.
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Liao PS, Lan WC, Wang CY, Lin CD, and Aoh Y
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- Humans, Adult, Female, Semicircular Canals, Face, Bell Palsy diagnosis, Bell Palsy etiology, Bell Palsy therapy, Facial Paralysis complications, Cholesteatoma complications, Cholesteatoma diagnosis, Cholesteatoma surgery, Cholesteatoma congenital
- Abstract
Introduction: Cholesteatoma is a rare disease characterized by the accumulation of keratinized squamous epithelial cells in the middle ear or mastoid cavity. Vertigo and facial palsy, which are rare complications, may indicate erosion into the semicircular canals or the fallopian canal., Patient Concerns: A 40-year-old woman presented to our clinic with progressive right-sided hearing loss over 5 years (primary concern). Approximately 10 years ago, the patient had developed acute right-sided facial weakness with no additional symptoms. A neurologist at another hospital had diagnosed her condition as Bell's palsy and treated it accordingly., Diagnosis: Adult-onset congenital cholesteatoma in the hypotympanum., Intervention: Combined endoscopic and microscopic removal of the cholesteatoma., Outcomes: Physical examination revealed slight improvement in right-sided peripheral facial palsy., Lesson: Routine eardrum examination is recommended for patients presenting with isolated peripheral facial palsy. If necessary, a patient should be referred to an otologist for further evaluation and treatment., Competing Interests: The authors have no funding and conflicts of interest to disclose., (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2024
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140. Junior doctors' workplace well-being and the determinants based on ability-motivation-opportunity (AMO) theory: Educational and managerial implications from a three-year longitudinal observation after graduation.
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Lin YK, Lin CD, and Lin BY
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Purpose: Junior doctors function as trainees from an educational perspective and as employees from a human resource management perspective. Employing the ability-motivation-opportunity (AMO) theory as a conceptual framework, this study longitudinally investigated the factors affecting the workplace well-being and career progression of junior doctors over a 3-year period following their graduation from medical schools., Materials and Methods: This 3-year prospective cohort study enrolled junior doctors who graduated from 2 medical schools in June 2019 in Taiwan. This study collected data by implementing web-based, self-administered structured questionnaires at 3-month intervals between September 2019 and July 2022. The collected data encompassed ability indicators (i.e. academic performance and perceived preparedness for clinical practice), motivation indicators (i.e. educational and clinical supervision), opportunity indicators (i.e. clinical unit cultures), and workplace well-being indicators (i.e. burnout, compassion satisfaction, and job performance). A total of 107 junior doctors participated, providing 926 total responses. The data were analysed using univariate analyses and structural equation modelling with path analysis., Results: Over the 3-year period following graduation, the junior doctors' confidence in their preparedness for clinical practice and the educational and clinical supervision had varying degrees of influence on the junior doctors' workplace well-being. The influence of clinical unit cultures, which can provide opportunities for junior doctors, became evident starting from the second year postgraduation; notably, unit cultures that emphasised flexibility and discretion played positive and critical roles in enhancing the junior doctors' workplace well-being lasted to the third year., Conclusions: Our findings provide insights into the distinct critical factors that affect the socialisation of junior doctors within workplace environments over 3 consecutive years. These findings can provide guidance for medical educators and healthcare managers, helping them understand and support the progressive integration of junior doctors into their work environments.
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- 2024
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141. Endoscopic Versus Microscopic Type I Tympanoplasty: An Updated Systematic Review and Meta-analysis.
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Wang TC, Shih TC, Chen CK, Hsieh VC, Lin DJ, Tien HC, Chen KC, Tsai MH, Lin CD, and Tsai CH
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- Humans, Microsurgery methods, Treatment Outcome, Operative Time, Tympanoplasty methods, Endoscopy methods
- Abstract
Objective: Our objective was to perform a systematic review and meta-analysis comparing the clinical outcomes after endoscopic and microscopic type I tympanoplasty., Study Design: Randomized controlled trials, two-arm prospective studies, and retrospective studies were included., Setting: Medline, Cochrane, EMBASE, and Google Scholar databases were searched until March 1, 2022 using the combinations of search terms: "endoscopic," "microscopic," and "tympanoplasty.", Methods: Two independent reviewers utilized the abovementioned search strategy to identify eligible studies. If any uncertainty existed regarding eligibility, a third reviewer was consulted. Primary outcome measures were graft success rate, air-bone gap (ABG) improvement, and operative time. Secondary outcomes were the rate of need for canalplasty, the proportion of self-rated excellent cosmetic results, and pain visual analog scale (VAS)., Results: Forty-three studies enrolled a total of 3712 patients who were undergoing type I tympanoplasty and were finally included. The pooled result showed endoscopic approach was significantly associated with shorter operative time (difference in means: -20.021, 95% confidence interval [CI]: -31.431 to -8.611), less need for canalplasty (odds ratio [OR]: 0.065, 95% CI: 0.026-0.164), more self-rated excellent cosmetic results (OR: 87.323, 95% CI: 26.750-285.063), and lower pain VAS (difference in means: -2.513, 95% CI: -4.737 to -0.228). No significant differences in graft success rate or ABG were observed between the two procedures., Conclusion: Endoscopic type I tympanoplasty provides a similar graft success rate, improvement in ABG, and reperforation rate to microscopic tympanoplasty with a shorter operative time, better self-rated cosmetic results, and less pain. Unless contraindicated, the endoscopic approach should be the procedure of choice in type I tympanoplasty., (© 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.)
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- 2024
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142. Bacteriology of Different Phenotypes of Chronic Rhinosinusitis.
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Li YT, Huang SS, Ma JH, Hsieh BH, Tsou YA, Lin CD, Tai CJ, and Shih LC
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- Humans, Retrospective Studies, Case-Control Studies, Quality of Life, Phenotype, Chronic Disease, Nasal Polyps complications, Nasal Polyps surgery, Nasal Polyps diagnosis, Methicillin-Resistant Staphylococcus aureus, Bacteriology, Rhinosinusitis, Rhinitis diagnosis, Sinusitis diagnosis
- Abstract
Objectives: Chronic rhinosinusitis (CRS) reduces the health-related quality of life and subsequently causes a tremendous socio-economic impact. Although many studies have been conducted, few have identified a relationship between bacteriological characteristics and different phenotypes or endotypes. Therefore, this study aimed to elucidate the recent trends in bacterial cultures from different types of CRS in the Asian population., Methods: This retrospective case-control study recruited patients diagnosed with CRS who underwent functional endoscopic sinus surgery (FESS) at a tertiary hospital in Taiwan. The patients were classified into those with chronic rhinosinusitis with nasal polyps (CRSwNP)/chronic rhinosinusitis without nasal polyps (CRSsNP), eosinophilic chronic rhinosinusitis (eCRS)/non-eosinophilic chronic rhinosinusitis (NECRS), and central compartment atopic disease (CCAD)/lateral-dominant nasal polyp (LDNP) groups. The demographic data and bacteriological characteristics of the groups were analyzed., Results: We included 503 patients, identifying no significant difference between CRSwNP and CRSsNP for several common bacteria in CRS. The number of Staphylococcus epidermidis isolates in culture was significantly higher in the NECRS group (50.46% vs. 32.56%, p = 0.0003) than that in the eCRS group. The number of methicillin-resistant Staphylococcus aureus (MRSA; 8.51% vs. 2.35%, p = 0.0221) positive isolates was significantly higher in the CCAD group than that in the LDNP group., Conclusions: This was the first study in Asia to analyze the relationship between bacteriological characteristics and CCAD. MRSA is significantly higher in the CCAD group than that in the LDNP group. Recognizing the unique microbiology of CRSwNP, eCRS, and CCAD is crucial when selecting antimicrobial therapy to lessen the socio-economic impact., Level of Evidence: 3 Laryngoscope, 134:1071-1076, 2024., (© 2023 The American Laryngological, Rhinological and Otological Society, Inc.)
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- 2024
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143. Chronic Rhinosinusitis and Premorbid Gastrointestinal Tract Diseases: A Population-Based Case-Control Study.
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Wu SS, Hung TH, Liao PS, Tsou YA, Hung YT, Lin CD, Tai CJ, Shen TC, and Shih LC
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Objectives: The primary aim was to determine the prevalence of gastrointestinal diseases in patients with chronic rhinosinusitis (CRS), utilizing the National Health Insurance Research Database (NHIRD) in Taiwan. Several studies have supported the existence of distinct immune patterns between the Asian and Western populations in CRS patients. Through the population-based case-control study, we could compare the differences between various regions and provide further treatment strategies for subsequent studies in Asian CRS patients. The secondary aim was to assess whether different types of CRS influence the correlation with specific GI diseases. Understanding how different phenotypes or endotypes of CRS may relate to distinct GI disease patterns could provide valuable insights into the underlying mechanisms and potential shared pathways between these conditions. Methods: We use the NHIRD in Taiwan. Newly diagnosed patients with CRS were selected between January 1, 2001 and December 31, 2017 as the case group, and the controls were defined as individuals without a history of CRS. Patients with CRS were divided into two groups: with nasal polyps and without nasal polyps. We also separated GI tract diseases into four groups based on their different pathophysiologies. Results: This study included 356,245 participants (CRS: 71,249 and control: 284,996). The results showed that CRS was significantly associated with some specific GI tract diseases, including acute/chronic hepatitis B, gastroesophageal reflux disease (GERD) with/without esophagitis, achalasia of cardia, peptic/gastrojejunal ulcer, Crohn's disease, and ulcerative colitis. In addition, when CRS was subcategorized into chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP), GERD with esophagitis and peptic ulcer were significantly associated with CRSsNP. Conclusions: A significant association between CRS and premorbid GI tract diseases has been identified. Remarkably, GERD with esophagitis and peptic ulcer were significantly associated with CRSsNP. The underlying mechanisms require further investigation and may lead to new treatments for CRS. Researchers can further investigate the mechanisms by referring to our classification method to determine the implications for diagnosis and treatment., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2023
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144. Long-term rare giant sialolithiasis for 30 years: A case report and review of literature.
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Mao JS, Lee YC, Chi JC, Yi WL, Tsou YA, Lin CD, Tai CJ, and Shih LC
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Background: Sialolithiasis is one of the most common salivary gland disorders, most commonly affecting the submandibular gland. Submandibular sialolithiasis can be treated using non-invasive conservative measures and invasive treatments. Treatment selection was based on the ductal system anatomy and the size and location of the stones. This study aimed to review the updates on sialolithiasis treatment and compare the different management strategies of the variables., Case Summary: This report presents a case of a long-term, rare, and giant sialolithiasis within the submandibular gland parenchyma for 30 years in an older adult. Our patient presented with painless right submandibular swelling. Computed tomography revealed a calcified mass measuring 35 mm × 20 mm within the right submandibular gland. In this case, the infection and fibrosis of the affected gland and size of the stone did not provide us with other alternatives except for the excision of the involved gland. Thus, right submandibular sialoadenectomy was performed via the transcervical approach. After the surgery, the patient recovered without any complaints, side effects, or complications., Conclusion: Tailored management is important for preserving gland function, maintaining low risk, and reducing patient discomfort., Competing Interests: Conflict-of-interest statement: The authors declare no conflict of interest., (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
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- 2023
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145. Relapsing autoimmune inner ear disease with significant response to methotrexate and azathioprine combination therapy: A case report and mini literature review.
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Huang KH, Lin HC, Lin CD, and Wu PC
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- Humans, Female, Adult, Methotrexate therapeutic use, Azathioprine therapeutic use, Immunosuppressive Agents therapeutic use, Methylprednisolone therapeutic use, Adrenal Cortex Hormones therapeutic use, Recurrence, Autoimmune Diseases drug therapy, Hearing Loss, Sensorineural drug therapy, Labyrinth Diseases drug therapy
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Rationale: Autoimmune inner ear disease typically presents with bilateral hearing loss that progresses over weeks or months though its mechanisms are unknown. Corticosteroids are the first-line treatment, but their responses are variable and relapses are frequent. Thus, many experts have sought to replace corticosteroids with immunosuppressive agents., Patient Concerns: A 35-year-old woman experienced a progressive hearing impairment, initially on the left side and later becoming bilateral. Her response to corticosteroid monotherapy was temporary, and there have been two relapse episodes over several months., Diagnoses: Autoimmune inner ear disease was considered due to evidence of autoimmunity combined with a clinical course of bilateral and recurrent sensorineural hearing loss and a partial response to corticosteroid therapy., Interventions: The patient received a 3-day mini-pulse of methylprednisolone at 250 mg/d, followed by 12 mg/d maintenance, and concurrently began an azathioprine regimen gradually increasing to 100 mg/day as a corticosteroid-sparing agent., Outcomes: Three weeks after immunosuppressive therapy, hearing and pure-tone audiometry improved, and after 7 weeks, methylprednisolone was tapered to 8 mg/d. The dosage was further reduced by adding methotrexate at 7.5 mg/week, resulting in a reduction to 4 mg/d as maintenance therapy after 4 weeks., Lessons: For patients who are unresponsive to corticosteroids or experience difficulty tolerating them, a combination therapy of methotrexate and azathioprine is recommended as a viable alternative as this regimen is well-tolerated and yields positive outcomes., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)
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- 2023
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146. Increased Incidence of Dysmenorrhea in Women Exposed to Higher Concentrations of NO, NO 2 , NO x , CO, and PM 2.5 : A Nationwide Population-Based Study.
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Lin SY, Yang YC, Lin CC, Chang CY, Hsu WH, Wang IK, Lin CD, Hsu CY, and Kao CH
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- Dysmenorrhea epidemiology, Female, Humans, Incidence, Particulate Matter adverse effects, Taiwan epidemiology, Nitric Oxide, Nitrogen Dioxide analysis
- Abstract
Background: Air pollution is speculated to affect the reproductive health of women. However, a longitudinal association between exposure to air pollution and dysmenorrhea has not been identified, which this study aimed to examine this point. Methods: Two nationwide databases, namely the Taiwan Air Quality Monitoring database and the Taiwan National Health Research Institutes database were linked. Women with a history of dysmenorrhea (International Classification of Disease, Ninth Revision, Clinical Modification code 625.3) before 2000 were excluded. All participants were followed from January 1, 2000 until the diagnosis of dysmenorrhea, withdrawal from National Health Insurance, or December 31, 2013. Furthermore, air pollutants were categorized into quartiles with three cut-off points (25th, 50th, and 75th percentiles). The Cox regression model was used to calculate the hazard ratios of dysmenorrhea. Results: This study enrolled 296,078 women. The mean concentrations of yearly air pollutants were 28.2 (±12.6) ppb for nitric oxides (NO
x ), 8.91 (±7.93) ppb for nitric oxide (NO), 19.3 (±5.49) ppb for nitrogen dioxide (NO2 ), 0.54 (±0.18) ppm for carbon monoxide (CO), and 31.8 (±6.80) μg/m3 for PM2.5 . In total, 12,514 individuals developed dysmenorrhea during the 12-year follow-up. Relative to women exposed to Q1 concentrations of NOx , women exposed to Q4 concentrations exhibited a significantly higher dysmenorrhea risk [adjusted hazard ratio (aHR)= 27.9, 95% confidence interval (CI) = 21.6-31.3]; similarly higher risk was found for exposure to NO (aHR = 16.7, 95% CI = 15.4-18.4) and NO2 (aHR = 33.1, 95% CI = 30.9-37.4). For CO, the relative dysmenorrhea risk in women with Q4 level exposure was 28.7 (95% CI = 25.4-33.6). For PM2.5 , women at the Q4 exposure level were 27.6 times (95% CI = 23.1-29.1) more likely to develop dysmenorrhea than those at the Q1 exposure level. Conclusion: Our results showed that women would have higher dysmenorrhea incidences while exposure to high concentrations of NO, NO2 , NOx , CO, and PM2.5 ., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Lin, Yang, Lin, Chang, Hsu, Wang, Lin, Hsu and Kao.)- Published
- 2021
- Full Text
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147. Medical students' preclinical service-learning experience and its effects on empathy in clinical training.
- Author
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Yang YS, Liu PC, Lin YK, Lin CD, Chen DY, and Lin BY
- Subjects
- Curriculum, Empathy, Humans, Taiwan, Clinical Clerkship, Students, Medical
- Abstract
Background: Service learning (SL) is an educational methodology presumed to help medical students be more empathetic and compassionate. We longitudinally investigated the level of empathy in medical students and how preclinical SL experience was related to their level of empathy in their clinical clerkships., Methods: Our cohort comprised fifth-year medical students engaged in clerkships as part of a 7-year medical programme at one medical school in Taiwan. Surveys were conducted at the beginning of the clerkship in September 2015 (T1) to collect data on the medical students' preclinical SL experience in curriculum-based service teams (CBSTs) and extracurricular service teams (ECSTs) and their SL self-efficacy, demographic characteristics, and empathy level. Subsequently, three follow-up surveys were conducted once every 3 months to determine the empathy level of the students during their clinical clerkships (T2-T4). Seventy students who returned the written informed consent and completed the baseline (T1) and two or more follow-up surveys (T2-T4) were included in our analysis with the response rate of 34%. In total, 247 responses across the 1-year clerkship were analysed. Descriptive statistics, paired t tests, and generalised estimating equations were employed., Results: Our study revealed that changes in empathy level in the dimensions of perspective taking, compassionate care, and standing in patients' shoes in their clinical clerkships. Relative to that at T1, their empathy decreased in perspective taking and compassionate care at T2-T4 but increased in standing in patients' shoes at T3. Additionally, our study verified the positive effect of medical students' preclinical SL experience in CBSTs and ECSTs on empathy in terms of compassionate care and perspective taking, respectively, but not on that of standing in patients' shoes., Conclusions: Separate investigations into subconstructs of empathy, such as perspective taking, compassionate care, and standing in patients' shoes, in medical students may be necessary for exploring the various driving forces or barriers to developing empathy in medical students. Moreover, SL experience through both CBSTs and ECSTs at medical academies may have positive effects on medical students' empathy in their clinical clerkships and should be promoted at medical schools.
- Published
- 2021
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148. Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers.
- Author
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Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schürch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, and Jackson PK
- Abstract
We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during respiratory transmission. We further determined whether ACE2 expression in the cilia of upper respiratory cells was influenced by patient demographics, clinical characteristics, co-morbidities, or medication use, and found no evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) increases ACE2 protein expression.
- Published
- 2020
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149. Immunoglobulin G4-Related Disease Presented as Recurrent Otitis Media and Mixed Hearing Loss Treated With Cyclophosphamide and Rituximab: A Case Report.
- Author
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San S, Lin CD, Tsai ST, Lin CC, and Wu PC
- Abstract
Immunoglobulin G4-related disease (IgG4-RD) is a systemic autoimmune disease; however, it rarely presents as recurrent otitis media and mixed hearing loss. In this article, we present a 43-year-old male patient who presented with recurrent otitis media and mixed hearing loss that is the 12th case of IgG4-RD with middle and inner ear involvement. We also report the clinical response of cyclophosphamide and rituximab therapy in IgG4- RD. These two drugs have never been used to treat otologic symptoms, but were used to treat other organs affected by IgG4-RD. One year later, the patient underwent mastoidectomy of the right ear and the pathological reports revealed IgG4-related disease. A rheumatologist administered immunosuppressive therapy comprising cyclophosphamide and rituximab. After therapy, patient's right-sided mixed hearing loss partially improved. We recorded all pure tone audiometry data to evaluate the clinical course and treatment effect. Finally, we concluded that pathological confirmation and further immunosuppressive therapy should be considered in a timely manner to prevent hearing impairment. We recommend cyclophosphamide and rituximab for the treatment of diseases involving the middle and inner ear., Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
- Published
- 2018
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150. Pentoxifylline versus Steroid Therapy for Idiopathic Sudden Sensorineural Hearing Loss with Diabetes.
- Author
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Lan WC, Wang CY, and Lin CD
- Subjects
- Administration, Intravenous, Administration, Oral, Aged, Audiometry, Pure-Tone methods, Blood Glucose analysis, Blood Glucose drug effects, Dexamethasone administration & dosage, Dexamethasone therapeutic use, Diabetes Complications, Diabetes Mellitus drug therapy, Diabetes Mellitus epidemiology, Female, Glucocorticoids therapeutic use, Hearing drug effects, Hearing Loss, Sensorineural drug therapy, Hearing Loss, Sensorineural physiopathology, Hearing Loss, Sudden physiopathology, Humans, Male, Middle Aged, Pentoxifylline administration & dosage, Phosphodiesterase Inhibitors therapeutic use, Prednisolone administration & dosage, Retrospective Studies, Treatment Outcome, Hearing Loss, Sensorineural diagnosis, Hearing Loss, Sudden diagnosis, Pentoxifylline therapeutic use, Prednisolone therapeutic use
- Abstract
Objectives: To compare the efficacy of pentoxifylline with that of conventional steroid therapy in diabetic patients with idiopathic sudden sensorineural hearing loss (ISSNHL) and to compare blood sugar levels during hospitalization., Materials and Methods: Medical charts were retrospectively reviewed for all diabetic patients admitted to one institution for ISSNHL between 2000 and 2015. We analyzed 298 cases; 50 patients received pulse steroid treatment (steroid group) and 248 received intravenous administration of pentoxifylline only (pentoxifylline group). Hearing change was evaluated by comparing the initial hearing tests with follow-up hearing tests for up to 3 months. Blood sugar levels were also compared between the 2 groups., Results: At 3 months post-treatment, the degree of hearing recovery was similar between the 2 groups. The pure-tone average was improved from baseline by 17.9±21.2 dB in the steroid group and 18.9±20.7 dB in the pentoxifylline group (p=0.776); hearing recovery rates were also similar (40% vs 39.1%; p=0.826). During hospitalization, average fasting blood sugar levels were higher (203.9±92.0 vs 174.4±54.8 mg/dL; p=0.033) and acute hyperglycemia was more common (48.0% vs 33.1%; p=0.044) with steroid versus pentoxifylline treatment., Conclusion: Hearing recovery rates did not significantly differ between steroid and pentoxifylline treatment in diabetic patients with ISSNHL, but pentoxifylline appeared to be associated with better blood sugar control.
- Published
- 2018
- Full Text
- View/download PDF
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