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In this study, highly active Au-decorated Pd heterogeneous nanocubes with Pd/Au molar ratios ranging from 15 : 1 to 2 : 1 were successfully synthesized based on a successive reduction strategy. The structure, morphology and composition of the as-prepared catalysts were characterized by X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), transmission electron microscopy (TEM), high-resolution TEM (HR-TEM), energy dispersive spectrometer (EDS) line scan and the elemental mapping. The results show that the lattice orientations of the Pd nanocubes match those of the Au layers. Structural analysis establishes that the surface of the Au-decorated Pd nanocrystal shows its {111} faces. The heterogeneous nanocubes were used for ethanol electro-oxidation reaction in alkaline media. The electrochemical results indicate that the addition of Au to Pd can significantly improve the performance including catalytic activity, CO tolerance and stability. These results clearly suggest that the relative amounts of Au and Pd on the surface of the nanocubes are crucial for the improvement of Pd catalysis, and Pd5Au1 is identified as the most efficient catalyst since it possesses superior catalytic activity and long-term stability.

Precise characterization of a monolayer of two different biomolecules in a gradient pattern on a glass surface puts high demand on the method used. Some techniques can detect protein monolayers but not on a glass surface. Others can distinguish between different proteins but not identify a gradient pattern. Here, we used ToF-SIMS to validate the complete surface composition, checking all the necessary boxes. As these types of surfaces can dictate sensitive cell behaviors, the precision on a nanolevel is crucial, and to visualize and determine the molecular distribution become essential. The dual monolayer consisted of laminin 521 and one of three other biomolecules of different sizes, epidermal growth factor, growth differentiation factor 5, or bovine serum albumin, creating opposing gradient patterns. The resulting ToF-SIMS imaging and line scan data provided detailed information on the distribution of the adsorbed proteins.

Coastal ecosystems are increasingly threatened by a wide range of human activities. Fish otolith chemistry, by creating a unique specific signature, can be used as a natural tag for determining life stage dispersal, spatial connectivity and population structure. In this study, we tested whether differences in otolith composition among juveniles of gilthead sea bream, Sparus aurata, could enable their proper allocation to polluted areas based on higher concentrations of elements related to contaminants. Otoliths were embedded, sectioned and analysed by LA-ICP-MS in line scan mode. Multivariate analysis confirmed clear separation between sites and elements. Samples from the site under the strongest anthropogenic impact from industrial and agricultural river input were characterized by higher values of Pb/Ca and Zn/Ca. However, these relatively low values likely do not have a negative effect on S. aurata recruitment, though they could serve for identifying the contribution of polluted nurseries to stock dynamics.

The present work has been conducted in order to investigate the quality of impregnation of unsaturated polyester resin across the bleached alfa pulpboard, and evaluate the potential for the obtained compound to serve a purpose as a useful composite material. The ultra-low-angle Microtomy (ULAM) method was used to study the quality of impregnation of alfa fibres by unsaturated polyester resin. The cross-section through the bleached alfa pulpboard/unsaturated polyester material, which emphasised the impregnation zone, was analysed using X-ray photoelectron spectroscopy (XPS). The profiles obtained by the XPS line scan analysis of the tapered surface show a well-defined impregnation region. The depth of this region has been characterised using two chemical constituent peaks, which showed an approximate depth of impregnation of about 20 to 40 μm, on the basis of C-OH/C-O-C, components which are exactly complementary to the β-shifted carbon signal, employed as an analogue for the unsaturated polyester. A comparative study was also carried out between the mechanical and tribological properties of the composite material and the pure unsaturated polyester resin, in order to complement the results obtained by surface analysis. The comparison shows better stiffness, tensile strength at break and wears resistance in the reinforced unsaturated polyester resin. The results of this research demonstrate a good quality of impregnation of unsaturated polyester resin across the short alfa fibres which present the matrix and reinforcement of the studied composite material.

In addition to being a serious threat to aircraft safety, kiss-bonding is also difficult to detect using conventional non-destructive testing techniques. It is the objective of this study to develop an autonomous high resolution technique to detect kiss-bonds and disbonds between carbon nanotube (CNT) skins and the host substrate of large-scale nanocomposite structures. The newly developed automated dynamic line-scan thermography (LST) approach is capable of speedy detection (up to 50 mm/s) of contact kiss-bonds as well as disbonds in laminated CNT-reinforced nanocomposite.

We have developed a multi-functional laser speckle imaging system, which can be operated in both the surface illumination laser speckle contrast imaging (SI-LSCI) mode and the line scan laser speckle contrast imaging (LS-LSCI) mode. The system has been applied to imaging the chicken embryos to visualize both the blood flow and morphological details of the vasculature. The experimental results demonstrated that LS-LSCI is capable of detecting and quantifying blood flow in blood vessels smaller and deeper than those detectable by conventional SI-LSCI. Furthermore, the line scan mode is also capable of producing depth-resolved absorption-based morphological images of tissue, augmenting flow-based functional images.

Ibrahim S. El-Deeb and Ezzat A. Showaib ABSTRACT Reverse engineering is the process of reconstructing a computer model for physical object based on 3D data point captured from the surface of the object. This work presents a low end and extremely cost effective technique for representing the free form surfaces of physical objects in a CAD model. An analogue signal was used to acquire the free form surface data unlike conventional methods like laser scanners or Coordinate Measurement Machines (CMM). The surface was scanned using a Linear Variable Differential Transducer, (LVDT) as position sensor for measuring the data from the surface of the object. The analogue signal was acquired through a data acquisition system in a continuous fashion to PC. Solid works CAD/CAM software was used to obtain the free form surface from the acquired 3D data using spline technique. A dedicated system was constructed to collect data using vertical milling machine. The benefit of this scanning technique is the ability to scan the target free form surface of the physical object in the following aspect: cost effective scanning technique, low end acceptable accuracy, speed and ease of calibration. Special software was built to minimize the data acquired during the scanning operation for reducing modeling time. KEYWORDS 3D digitizing; reverse engineering; surface modeling; line scan For More Details: https://wireilla.com/engg/ijmech/papers/1212ijmech03.pdf

The 3d surface reconstruction with active line-scan camera systems generally require a special approach for generating powerful structured light. For our system, we use a structured light approach based on distributed projection of a LED line light. The pattern generated by this kind of structured light are extremely height dependent and provide an inhomogeneous measurement accuracy. Thus, it is necessary to determine pattern sequences providing precise 3d measurements over the whole measuring range. For this we first define average-free pattern sequences, which can be normalized and evaluated in terms of their local correlation properties. Based on that definition we propose a heuristic algorithm to choose optimal pattern sequences and verify its basic functionality.

Background: The aim of this study was to examine the influence of B-scan averaging on choroidal thickness using wide-field enhanced-depth imaging optical coherence tomography. Methods: Six high-resolution trans-foveal horizontal enhanced-depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B-scans, using the automated real-time image averaging and follow-up features of a Spectralis device. The impact of B-scan averaging on regional measures of wide-field choroidal thickness (across macular and peripheral regions) and their accuracy was investigated, assuming that averaging 100 B-scans would provide the most accurate estimate of choroidal thickness. Results: Regional estimates of wide-field choroidal thickness did not vary across the different B-scan averaging conditions (all p > 0.05). The mean choroidal thickness averaged across the full wide-field area exhibited the closest agreement to measures obtained with 100 averaged B-scans, when frame averaging exceeded 30 B-scans (95 per cent limits of agreement +10 to −7, +7 to −7 and +6 to −3 μm for 30, 40 and 50 averaged B-scans, respectively), compared to 10 and 20 averaged B-scans (95 per cent limits of agreement +13 to −8 and +13 to −6 μm, respectively; p < 0.01 and p < 0.02 compared to the accuracy of 50 averaged B-scans). Conclusion: Averaging 30 B-scans for an individual enhanced-depth imaging optical coherence tomography line scan provided accurate measures of choroidal thickness across a wide-field (60°) area in young healthy eyes. This information can assist in designing the volumetric scan protocols required for detailed examination of the macular and peripheral choroid.

Hyperspectral line-scan cameras are increasingly being deployed on mobile platforms operating in unstructured environments. To generate geometrically accurate hyperspectral composites, the intrinsic parameters of these cameras must be resolved. This article describes a method for determining the intrinsic parameters of a hyperspectral line-scan camera. The proposed method is based on a cross-ratio invariant calibration routine and is able to estimate the focal length, principal point, and radial distortion parameters in a hyperspectral line-scan camera. Compared to previous methods that use similar calibration targets, our approach extends the camera model to include radial distortion. It is able to utilize calibration data recorded from multiple camera view angles by optimizing the re-projection error of all calibration data jointly. The proposed method also includes an additional signal processing step that automatically detects calibration points in hyperspectral imagery of the calibration target. These contributions result in accurate estimates of the intrinsic parameters with minimal supervision. The proposed method is validated through comprehensive simulation and demonstrated on real hyperspectral line-scans.

Applications of machine vision techniques are prevalent for quality inspection of foods. For safety inspection of fruits such as apples to detect biological contaminants, a method to capture and reconstruct a whole-surface of apple is needed. In this paper, we present a reconstruction method for whole-surface imaging of apples with the use of a line-scan hyperspectral imaging technique. In addition, the development of online whole-surface inspection technology for round-fruits is presented.

Active thermography is a proven technology used in a wide variety of applications. In the most common approach using a static configuration, the elements involved in the inspection do not move. This presents serious drawbacks when it is applied to the inspection of large products and machines. An alternative approach is the dynamic inspection, which enables the inspection of large and complex products with better resolution, but it is also extremely challenging as data reconstruction is necessary. This work analyzes two methods for dynamic inspection using active infrared thermography: the thermal photocopier and the line scan. Automatic robust methods are proposed to calculate the temperature–time history, producing a pseudostatic sequence that can be further processed using advanced data processing algorithms to improve defect detection. Results demonstrate the robustness of the proposed methods and the ability to inspect large products with excellent results.

We have developed a high-speed line-scan optical microscope that is capable of acquiring high-resolution, high-contrast fluorescence images at more than 100 fps. This advanced imaging technique has been applied to multi-dimensional imaging of zebrafish heart.

Lane marking detection and localization are crucial for autonomous driving and lane-based pavement surveys. Numerous studies have been done to detect and locate lane markings with the purpose of advanced driver assistance systems, in which image data are usually captured by vision-based cameras. However, a limited number of studies have been done to identify lane markings using high-resolution laser images for road condition evaluation. In this study, the laser images are acquired with a digital highway data vehicle (DHDV). Subsequently, a novel methodology is presented for the automated lane marking identification and reconstruction, and is implemented in four phases: (1) binarization of the laser images with a new threshold method (multi-box segmentation based threshold method); (2) determination of candidate lane markings with closing operations and a marching square algorithm; (3) identification of true lane marking by eliminating false positives (FPs) using a linear support vector machine method; and (4) reconstruction of the damaged and dash lane marking segments to form a continuous lane marking based on the geometry features such as adjacent lane marking location and lane width. Finally, a case study is given to validate effects of the novel methodology. The findings indicate the new strategy is robust in image binarization and lane marking localization. This study would be beneficial in road lane-based pavement condition evaluation such as lane-based rutting measurement and crack classification.

Spectroscopic techniques for food quality analysis are limited to surface inspections and are highly affected by the superficial layers (skin or packaging material) of the food samples. The ability of spatially offset Raman spectroscopy (SORS) to obtain chemical information from below the surface of a sample makes it a promising candidate for the non-destructive analysis of the quality of packaged food. In the present study, we developed a line-scan SORS technique for obtaining the Raman spectra of packaged-food samples. This technique was used to quantify butter adulteration with margarine through two different types of packaging. Further, the significant commercial potential of the developed technique was demonstrated by its being able to discriminate between ten commercial varieties of butter and margarine whilst still in their original, unopened packaging. The results revealed that, while conventional backscattering Raman spectroscopy cannot penetrate the packaging, thus preventing its application to the quality analysis of packaged food, SORS analysis yielded excellent qualitative and quantitative analyses of butter samples. The partial least-square regression analysis predictive values for the SORS data exhibit correlation coefficient values of 0.95 and 0.92, associated with the prediction error 3.2 % and 3.9 % for cover-1 & 2, respectively. The developed system utilizes a laser line (ca. 14-cm wide) that enables the simultaneous collection of a large number of spectra from a sample. Thus, by averaging the spectra collected for a given sample, the signal-to-noise ratio of the final spectrum can be enhanced, which will then have a significant effect on the multivariate data analysis methods used for qualitative and/or qualitative analyses. This recently presented line-scan SORS technique could be applied to the development of high-throughput and real-time analysis techniques for determining the quality and authenticity various packaged agricultural products.

Limbal stem cell dysfunction (LSCD) causes morphological and physiological changes in the limbus that result in decreased vision, photophobia, tearing, chronic inflammation and hyperemia, recurrent episodes of pain, and blindness in severe cases. Currently, clinical in-vivo imaging of the palisaded of Vogt (POV) and the cellular structure of the limbal crypts in the human corneo-scleral limbus is accomplished by in-vivo confocal microscopy (IVCM). However, IVCM requires physical contact with the limbal tissue that can cause pain and inflammation. In this study, we used a novel high speed, ultra-high resolution optical coherence tomography (UHR-OCT) system to generate volumetric, cellular resolution image of the healthy and pathological human corneo-scleral limbus. The UHR-OCT system has a compact fiber-optic design. A femtosecond laser with 790 nm central wavelength and ~150 nm spectral bandwidth (at 3dB) was used to achieve ~1.4 µm axial resolution in biological tissue. The UHR-OCT system also utilizes a high resolution spectrometer (Cobra, Wasatch Photonics) connected to a novel line scan camera with a tall pixel design, 2048 pixel array and a maximum readout rate of 250 kHz. The system’s SNR was 96 dB at 100 µm away from the zero delay line, with ~10 dB roll-off over 1.5 mm scanning range for ~800 µm power of the imaging beam. Volumetric images of the POV and the cellular structure of the limbal crypts were acquired in-vivo and without contact with the limbal tissue from healthy and LSCD and subjects. This study was approved by the University of Waterloo Research Ethics Committee.

With outstanding features of high resolution and high acquisition rate, line-scan imaging holds great potentials for high-speed applications. This paper presents a stereo line-scan system for 3D shape measurement of fast moving objects. The principle and key technologies are addressed. The system setup and 3D imaging model are introduced first and the stereo matching scheme and calibration approach are described subsequently. The system is verified by experiments. The results demonstrate the validity and accuracy of the proposed system.

We present a method to perform imaging of GCaMP6 signals with high accuracy for single action potential detection over populations of neurons in the mouse brain using galvanometric mirrors and fast smart line scan trajectories.

The introduction of wide field optical coherence tomography (WF-OCT) has provided newer insights in the imaging of peripheral choroid. We evaluated choroidal thickness (CT) and large choroidal vessel thickness (LCVT) of 20 eyes in horizontal and vertical meridians using WF-OCT. A high-definition line scan through the fovea in both horizontal and vertical meridian was captured in primary and extremes of gaze to obtain scans up to mid-equator. CT and LCVT measurements were done across predefined points in macular area and all quadrants. LCVT was calculated after identifying a large choroidal vessel near choroidoscleral interface. The main outcome measures were differences in CT and LCVT in macular and four quadrants. Mean CT (331.23 ± 76.34 µ) and LCVT (201.46 ± 54.31 µ) in vertical macular segment were significantly more than CT (245.79 ± 55.38 µ; p = 0.0002) and LCVT (150.48 ± 52.58 µ; p = 0.004) in horizontal macular segment. CT at peripheral points in all quadrants was significantly reduced as compared to subfoveal CT (all p values

Many traditional image mosaic methods focus on image registration, and attempt to provide a discontinuous solution of overlapping images. However, the overlapping areas cannot be captured in some special situation such as airborne line scan camera. For this airborne imaging, we introduce a novel mosaic technique based on pixel subtle variations, which analyses the pixel signal on subtle variations in Taylor series expansion. To construct the correlation between line scan sub-images, the pixels at the same position in each line scan sub-image are viewed as 1D signal, and then the misalignment and displacement among sub-images can be depicted as pixel subtle variations in translational motion. With the reference of previous line scan sub-image, the subtle variations of adjacent sub-images can be evaluated and eliminated. Afterwards, a number of sub-images handled are almost aligned to compose an integral image without seam line. The experimental mosaic results on real sub-images of airborne line scan show the effectiveness of our method in achieving seamless zebra crossing image and the strong robustness to brightness.

BACKGROUND AND OBJECTIVE: To assess repeatability and speed of a line-scan ophthalmoscope (LSO) image-based tracking system and compare to the point-scanning approach. PATIENTS AND METHODS: Thirty-five eyes with retinal diseases underwent volume scans using two spectral-domain optical coherence tomography (OCT) devices: a line-scan tracking Cirrus HD-OCT (Carl Zeiss Meditec; Dublin, CA) and point-scan tracking Spectralis HRA+OCT (Heidelberg Engineering, Heidelberg, Germany). Eyes were also imaged on the Cirrus HD-OCT with tracking disabled. RESULTS: Mean difference in central subfield thickness (CST) between consecutive scans was 2.6 µm for the Cirrus without tracking, 1.7 µm with tracking, and 3.6 µm for the Spectralis. The repeatability standard deviation was 3.0 µm for the Cirrus without tracking, 1.5 µm with tracking, and 4.0 µm for the Spectralis. Coefficient of variation for the CST was 1.1% for the Cirrus without tracking, 0.5% with tracking, and 1.4% for the Spectralis. Mean scan acquisition time was 12.3 ± 6.2 seconds for the Spectralis, 7.8 ± 6.7 for the Cirrus with tracking, and 4.3 ± 0.6 for the Cirrus without tracking. CONCLUSION: Real-time LSO image-based retinal tracking appears to improve repeatability of OCT retinal thickness measurements. [ Ophthalmic Surg Lasers Imaging Retina . 2015;46:310–314.]

Purpose: To examine RTVue (Optovue, Inc) optical coherence tomography (OCT) as a method for measuring scleral thickness. Methods: A prospective, single-center study of eyes with a variety of ocular diseases (no scleral diseases) was performed to image scleral thickness utilizing the RTVue OCT. Repeated measurements of scleral thickness were performed using a line scan 3 mm from the limbus in the inferior nasal and inferior temporal quadrants of each eye. Obtained values were analyzed statistically. Results: A total of 25 eyes in 14 subjects were measured. An average of 3 measurements per location per eye were taken. The mean scleral thickness 3 mm from the limbus was 654.22 μm. The average standard deviation of the measurements from each location was 30.88 μm. The Original Research Article Cramer et al.; OR, 3(4): 95-99, 2015; Article no.OR.2015.016 96 boundary of the conjunctiva and sclera was easily distinguishable. Conclusion: The results of this study suggest that RTVue high-resolution OCT is a user-friendly modality for measuring scleral thickness.

PURPOSE Magnetic resonance (MR) imaging offers the highest sensitivity for detecting bone necrosis. We evaluated osteonecrosis in rabbit models by calculating the percentage of fat to (fat + water) [F/(F+W)] on MR spectroscopy (MRS) and compared MR spectroscopy and imaging findings with corresponding histological results. METHODS To model the natural course of articular osteonecrosis, we removed the fourth tarsal bone in 45 rabbits, froze it for 5 min in liquid nitrogen to produce complete cellular necrosis, and then replaced the bone into the knee joint. We performed Carr-Purcell-Meiboom-Gill proton spectroscopic imaging to assess necrotic bone at 3 days and one, 2, 3, 4, 8, 12, 16, and 20 weeks after osteonecrosis and calculated the percentage of F/(F+W) of each bone. We also performed conventional T1- and T2-weighted imaging and compared all data to histological findings to analyze the natural course of necrosis. RESULTS T1-weighted MR imaging demonstrated obvious low signal intensity at 2 to 8 weeks and recovery at 12 to 20 weeks, whereas T2-weighted imaging demonstrated inconsistent intensities throughout the period. The postoperative percentage of F/(F+W) measured using line scan MRS decreased to 8.88% at 3 weeks, 6.22% at 8 weeks, and 34.40% at 20 weeks results that were mostly consistent with MR imaging findings. Histological findings demonstrated complete absence of osteocyte nuclei and loss of osteoid-osteogenesis at 3 to 8 weeks. Recovery of bone marrow was identified as an increase in the area of fat after 12 weeks. CONCLUSION Osteonecrosis delineated by T1-weighted MR imaging demonstrated fat content in the bone marrow that correlated with histology. The present MRS modality can be used to calculate the percentage of F/(F+W) of osteonecrosis to enable objective assessment of recovery and quantification of osteonecrosis to provide a numerical value for osteonecrosis.

As explained in Sect. 4.4, an ice-core line-scanner (LS) is a device for recording the visual stratigraphy of ice cores in high-resolution (≈ 0.1 mm/pixel) digital images. In the case of the EDML Deep Ice Core, the LS device scans polished ice slabs cut lengthwise from every full metre of the EDML core, according to the cutting plan shown in Fig. 4.10.

Sunspot atmospheres are highly inhomogeneous hosting both quasi-stable and transient features, such as `umbral micro-jets' and dark fibril-like events. We seek to understand the morphological properties and formation mechanisms of small-scale umbral brightenings (SSUBs; analogous to umbral micro-jets) and to understand whether links between these events and short dynamic fibrils, umbral flashes, and umbral dots can be established. An SST filtergram time-series sampling the Ca II H line and a CRISP full-Stokes 15-point Ca II 8542 A line scan dataset were used. The average lifetime and lengths of 54 SSUBs identified in the sunspot umbra are found to be 44.2 seconds (sigma=20 seconds) and 0.56" (sigma=0.14"). The spatial positioning and morphological evolution of these events was investigated finding no evidence of parabolic or ballistic profiles nor a preference for co-spatial formation with umbral flashes. The presence of Stokes V profile reversals provided evidence that these events could form through the development of shocks in the chromosphere. The application of the weak-field approximation indicated that changes in the line-of-sight magnetic field were not responsible for the modifications to the line profile and suggested that thermodynamic effects are the actual cause of the increased emission. Finally, a sub-set of SSUBs were observed to form at the foot-points of short dynamic fibrils. Overall, we found no correlation between the spatial locations where these events were observed and the occurrence of umbral dots and umbral flashes. SSUBs, however, have lifetimes and spectral signatures comparable to umbral flashes and are located at the footpoints of short dynamic fibrils, during or at the end of the red-shifted stage. It is possible, therefore, that these features form due to the shocking of fibrilar material in the lower atmosphere upon its return under gravity., Comment: 11 pages, 9 Figures

Industrial optical inspection often requires high speed and high throughput of materials. Engineers use a variety of techniques to handle these inspection needs. Some examples include line scan cameras, high speed multi-spectral and laser-based systems. High-volume manufacturing presents different challenges for inspection engineers. For example, manufacturers produce some components in quantities of millions per month, per week or even per day. Quality control of so many parts requires creativity to achieve the measurement needs. At times, traditional vision systems lack the contrast to provide the data required. In this paper, we show how dynamic polarization imaging captures high contrast images. These images are useful for engineers to perform inspection tasks in some cases where optical contrast is low. We will cover basic theory of polarization. We show how to exploit polarization as a contrast enhancement technique. We also show results of modeling for a polarization inspection application. Specifically, we explore polarization techniques for inspection of adhesives on glass.

Purpose To investigate the distribution of outer retinal changes in hydroxychloroquine (HCQ) retinopathy and explore optical coherence tomography (OCT) protocols to maximize the sensitivity of HCQ retinopathy detection in Asian patients. Design Diagnostic validity assessment. Methods Setting: Institutional. Patient Population: Forty-eight eyes (24 patients) with HCQ retinopathy underwent 6-mm horizontal and vertical line scans and 6 × 6-mm 2 volume scans using spectral-domain OCT (SD-OCT), and 9-mm line scans and 6 × 6-mm 2 and 12 × 9-mm 2 volume scans using swept-source OCT (SS-OCT). Observation Procedures: Distances from the fovea to the defective photoreceptors were measured in the temporal, nasal, superior, and inferior directions from line scan OCT images. The sensitivity of retinopathy detection, indicated by photoreceptor defects, was compared among protocols. Main Outcome Measures: Detection of photoreceptor defects and distances from the fovea to the defects. Results The average minimum distance from the fovea to an area of photoreceptor defects was 1.84 ± 1.26 mm (mean ± standard deviation). The distances were greater than 3 mm horizontally and vertically in 15 (31.3%) and 17 (35.4%) eyes with HCQ retinopathy, respectively, and only wide-field line or volume scans could detect defects in the eyes. The 9-mm line scans detected HCQ retinopathy significantly better than 6-mm scans ( P P = .001). The 12 × 9-mm 2 volume scan detected retinopathy with the greatest sensitivity (100%). Conclusions Our study recommends a wide-field OCT scan to screen Asian patients taking HCQ medications.

Auf dem heutigen Stand der Technik der optischen Schüttgutsortierung werden Zeilenkameras mit einfachen Annahmen über die Teilchenbewegung kombiniert, um eine Ausschleusung bestimmter Teilchen zu ermöglichen. Kürzlich haben wir einen experimentellen optischen Bandsortierer mit einer Flächenkamera ausgestattet und gezeigt, dass durch das Verfolgen der Teilchen des Schüttguts die Güte der Vorhersagen und somit auch der Ausschleusung verbessert werden kann. In dieser Arbeit nutzen wir den Farbversatz zwischen den Farbkanälen einer Farbzeilenkamera, um in Echtzeit Informationen über die Bewegung der Teilchen abzuleiten. Dieser Ansatz erlaubt es, die Vorhersagen heutiger optischer Bandsortierer zu verbessern, ohne dass deren Hardware dafür angepasst werden muss.

Pt-coated Pd nanocubes enclosed with (100) planes were successfully synthesized using an epitaxial approach. Their microstructures were determined on the basis of their electron diffraction patterns and line scan energy-dispersive X-ray measurements by spotting on a single nanocube. These bimetallic nanocubes can be used as catalysts for an alkaline oxygen reduction reaction. The results of the rotating ring-disk electrode measurements indicated that these nanocubes displayed a 2.6 times greater specific activity than Pt nanoparticles.

We study the coupling of lateral and normal tip oscillations and its effect on the imaging process of frequency-modulated dynamic atomic force microscopy. The coupling is induced by the interaction between tip and surface. Energy is transferred from the normal to the lateral excitation, which can be detected as damping of the cantilever oscillation. However, energy can be transferred back into the normal oscillation, if not dissipated by the usually uncontrolled mechanical damping of the lateral excitation. For certain cantilevers, this dissipation mechanism can lead to dissipation rates larger than 0.01 eV per period. The mechanism produces an atomic contrast for ionic crystals with two maxima per unit cell in a line scan.

In this paper, a small-area cell array method of reducing number of SL drivers requiring large layout areas, where the SL drivers supplying programming currents are routed in the row direction in stead of the column direction for eFuse OTP memory IPs having less number of rows than that of columns such as a cell array of four rows by eight columns, and a core circuit are proposed. By adopting the proposed cell array and core circuit, the layout area of designed 32-bit eFuse OTP memory IP is reduced. Also, a V2V (=2V±10％) regulator necessary for RWL driver and BL pull-up load to prevent non-blown eFuse from being blown from the EM phenomenon by a big current is designed. The layout size of the designed 32-bit OTP memory IP having a cell array of four rows by eight columns is 13.4% smaller with 120.1㎛ × 127.51㎛ (=0.01531㎜ 2 ) than that of the conventional design with 187.065㎛ × 94.525㎛ (=0.01768㎜ 2 ).

Dismount skin detection from an aerial platform has posed challenges compared to ground-based platforms. A small, area scanning multispectral imager was constructed and tested on a Small Unmanned Aerial System (SUAS). Computer vision registration, stereo camera calibration, and geolocation from autopilot telemetry were utilized to design a dismount detection platform. The test expedient prototype was 2kg and exhibited skin detection performance similar to a larger line scan hyperspectral imager (HSI). Outdoor tests with a line scan HSI and the prototype resulted in an average 5.112% difference in Receiver Operating Characteristic (ROC) Area Under Curve (AUC). This research indicated that SUAS-based Spectral Imagers are capable tools in dismount detection protocols.

Paper defects mean that there are some defects in the paper such as hole, emboss, and fold during the paper production, which mainly results from the limitation of technological level. In the past time, artificial visual inspection and off-line checking were often used to detect the paper defects. However, its shortcoming was highlighted along with the improvement of industrial technology level and increasing demand for paper. In order to realize the online detection and markers for paper defects, the project designs the on-line detection system based on line-scan digital camera. Firstly, the principle and detection scheme of the system for the paper defects was presented. Then the overall structure of the system was designed. After that, the hardware circuit of the system was designed using TMS320F2812 as main control chip. It mainly consists of the function of each module and the working process of the system. Finally, the software of the image acquisition system was presented. With the experimental verification, the system has advantages of low cost, high efficiency and strong resistance to interference. The functions and indexes achieved the design requirements.

Biosensors are valuable tools used to image the subcellular localization and kinetics of protein activity in living cells. Signaling at the edge of motile cells that regulates cell protrusion and retraction is important in many aspects of cell physiology, and frequently studied using biosensors. However, quantitation and interpretation is limited by the heterogeneity of this signaling behavior; automated analytical approaches are required to systematically extract large data sets from biosensor studies for statistical analysis. Here we describe an automated analysis to relate the velocity at specific points along the cell edge with biosensor activity in adjoining regions. Time series of biosensor images are processed to interpolate a smooth edge of the cell at each time point. Profiles of biosensor activity (‘line scans’) are then calculated along lines perpendicular to the cell edge. An energy minimization method is used to calculate a velocity associated with each line scan. Sorting line scans by the proximal velocity has generated novel biological insights, as exemplified by analysis of the Src merobody biosensor. With the large data sets that can be generated automatically by this program, conclusions can be drawn that are not apparent from qualitative or ‘manual’ quantitative techniques. Our ‘LineScan’ software includes a graphical user interface (GUI) to facilitate application in other studies. It is available at hahnlab.com and is exemplified here in a study using the RhoC FLARE biosensor.