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589 results on '"Liu, Guangli"'

111. MCycDB: A curated database for comprehensively profiling methane cycling processes of environmental microbiomes

Author

Qian, Lu, primary, Yu, Xiaoli, additional, Zhou, Jiayin, additional, Gu, Hang, additional, Ding, Jijuan, additional, Peng, Yisheng, additional, He, Qiang, additional, Tian, Yun, additional, Liu, Jihua, additional, Wang, Shanquan, additional, Wang, Cheng, additional, Shu, Longfei, additional, Yan, Qingyun, additional, He, Jianguo, additional, Liu, Guangli, additional, Tu, Qichao, additional, and He, Zhili, additional

Published
2022
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113. Identification of Molecular Subtypes and a Prognostic Signature Based on Inflammation-Related Genes in Colon Adenocarcinoma

Author

Qiu, Chenjie, Shi, Wenxiang, Wu, Huili, Zou, Shenshan, Li, Jianchao, Wang, Dong, Liu, Guangli, Song, Zhenbiao, Xu, Xintao, Hu, Jiandong, and Geng, Hui

Subjects
molecule subtypes, Immunology, Kaplan-Meier Estimate, Adenocarcinoma, Lymphocytes, Tumor-Infiltrating, Biomarkers, Tumor, Tumor Microenvironment, Humans, Immunology and Allergy, Gene Regulatory Networks, Original Research, Interleukin-13, Tissue Inhibitor of Metalloproteinase-1, Phospholipase C gamma, immune infiltration, Brain-Derived Neurotrophic Factor, RC581-607, Prognosis, Gene Expression Regulation, Neoplastic, Nomograms, Gene Ontology, colon adenocarcinoma, inflammation, Colonic Neoplasms, Immunotherapy, Immunologic diseases. Allergy, Transcriptome, signature
Abstract

Both tumour-infiltrating immune cells and inflammation-related genes that can mediate immune infiltration contribute to the initiation and prognosis of patients with colon cancer. In this study, we developed a method to predict the survival outcomes among colon cancer patients and direct immunotherapy and chemotherapy. We obtained patient data from The Cancer Genome Atlas (TCGA) and captured inflammation-related genes from the GeneCards database. The package “ConsensusClusterPlus” was used to generate molecular subtypes based on inflammation-related genes obtained by differential expression analysis and univariate Cox analysis. A prognostic signature including four genes (PLCG2, TIMP1, BDNF and IL13) was also constructed and was an independent prognostic factor. Cluster 2 and higher risk scores meant worse overall survival and higher expression of human leukocyte antigen and immune checkpoints. Immune cell infiltration calculated by the estimate, CIBERSORT, TIMER, ssGSEA algorithms, tumour immune dysfunction and exclusion (TIDE), and tumour stemness indices (TSIs) were also compared on the basis of inflammation-related molecular subtypes and the risk signature. In addition, analyses of stratification, somatic mutation, nomogram construction, chemotherapeutic response prediction and small-molecule drug prediction were performed based on the risk signature. We finally used qRT–PCR to detect the expression levels of four genes in colon cancer cell lines and obtained results consistent with the prediction. Our findings demonstrated a four-gene prognostic signature that could be useful for prognostication in colon cancer patients and designing personalized treatments, which could provide new versions of personalized management for these patients.

Published
2021

135. An effective selective catalytic reduction catalyst contains oxygen bridge for NOx reduction based on low concentration of C3H6 at medium‐low temperatures.

Author

Liu, Fang, Hu, Yiling, Liu, Guangli, Liu, Qing, Tang, Zhonghua, and Yang, Li

Subjects
CATALYTIC reduction, OXYGEN reduction, CATALYST supports, CATALYSTS, CERIUM oxides, PETROLEUM refineries
Abstract

Summary: Ammonia slip in NH3‐SCR will lead to the formation of viscous salt, which may block the downward heat exchangers, which is particularly serious in oil refinery stations. Oil refinery stations are usually rich in low concentration propane (C3H6), and C3H6‐SCR is considered to be a very promising NOx emission reduction technology. This study reported an effective NOx reduction catalyst based on low concentration C3H6 at medium‐low temperature. CeO2 was used to optimize the catalyst, but instead of doping CeO2 to active component, and it was found that doping CeO2 on TiO2 to produce Ce‐Ti synthetic support was effective. This study elucidates that in refinery tail gas environment, a 5 wt.% Mn loaded on Ce‐Ti support catalyst (Mn5‐Ce/TiO2) can achieve 70% NO conversion, meanwhile the N2 selectivity is 100%. In order to explore the mechanism of activity enhancement, the catalysts were characterized before and after reaction. The results indicate that the addition of CeO2 provided more acid sites for the adsorption of propene, and the structure and properties of Mn5‐Ce/TiO2 hardly changed after reaction, which helped to maintain high activity in de‐NOx process. The oxidation of Ce3+ to Ce4+, and the reduction of Mn3+ to Mn2+promoted the reduction of NO, while the oxygen bridge Ce‐O‐Ti promoted the stability of the catalyst, so as to achieve a high conversion of NO. [ABSTRACT FROM AUTHOR]

Published
2022
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136. External Field‐Driven Untethered Microrobots for Targeted Cargo Delivery.

Author

Zhu, Shilu, Chen, Yin, Liu, Guangli, Qian, Haisheng, Niu, Fuzhou, Wang, Ying, Zhao, Yuliang, Luo, Tingting, and Yang, Runhuai

Subjects
MICROROBOTS, CONTROLLED release drugs, DRUG delivery systems, FREIGHT & freightage, SMART materials
Abstract

Untethered microrobots (UMRs) propelled by multiple external power sources have emerged as promising tools for biomedical applications, such as targeted cargo delivery (TCD), microsurgery, thrombolysis, medical imaging, etc. In particular, owing to their minimal invasiveness and capability of accessing hard‐to‐reach regions of the human body in a controllable manner, the application of UMRs for TCD is of great interest in recent years. Here, the state‐of‐the‐art UMRs in this regard are presented, focused on targeted drug and cell delivery systems. Meanwhile, this review systematically details recent research studies on the use of UMRs in TCD, containing their constituent materials (functional, scaffold, and smart materials), fabrication methods, and three types of external propulsion energy sources concerning their mechanisms and corresponding typical designs. Subsequently, various strategies for controlled drug release are summarized, as well as the latest targeted cell delivery systems and relevant cell manipulation in vitro or in ex vivo. Finally, the current challenges to clinical translation faced by the UMRs and future perspectives on this field are highlighted. [ABSTRACT FROM AUTHOR]

Published
2022
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140. Application of the 2, 4-dichlorophenoxyacetic acid online monitoring using immunosensor technology

Author

YU Qiongzhen, ZHANG Chenglin, ZHU Zhihua, CUI Wanjun, LIU Guangli, SONG Baodong, WANG Wei, and YE Bo

Subjects
lcsh:Science (General), 2,4-dichlorophenoxyacetic acid (2,4-D), online immunosensor, water quality alert, lcsh:Q1-390
Abstract

The 2, 4-dichlorophenoxyacetic acid (2, 4-D) online immunosensor was characterized from the point of application in this study. Our experimental results showed that Logistic curve could be used to describe the response of 2, 4-D online immunosensor to the 2, 4-D concentration. In a range of 10~200 μg/L of 2, 4-D, half logarithmic linear equation could be used to describe the response of 2, 4-D online immunosensor to the 2, 4-D concentration. The memory effect happened on the 2, 4-D online immunosensor. According to 48 series of data, the total error of determination in the 2, 4-D online immunosensor was lower than that in the labor measurement. The 2, 4-D online immunosensor could be used in the Xijiang River with high operational stability and signal reliability. Our results should provide a promising way to realize the online early warning management on toxic organic compounds in water environment.

Published
2018

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