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112. Cover Image

Author

Zhao, Yuhui, primary, Bai, Yan, additional, Li, Yang, additional, Dong, Yu, additional, Guo, Yuhao, additional, Wang, Wen, additional, and Liu, Huirong, additional

Published
2021
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124. Strategies to halt 2019 novel coronavirus (COVID‐19) spread for organ transplantation programs at the Sichuan Academy of Medical Science and Sichuan Provincial People’s Hospital, China

Author

Wang, Yi, Liu, Huirong, Buhler, Leo H., and Deng, Shaoping

Subjects
China, Cross Infection, Clinical Laboratory Techniques, SARS-CoV-2, Pneumonia, Viral, COVID-19, Organ Transplantation, Brief Communication, Kidney Transplantation, Tissue Donors, Liver Transplantation, Betacoronavirus, Intensive Care Units, COVID-19 Testing, Treatment Outcome, Communicable Disease Control, Humans, Coronavirus Infections, Pandemics, Lung Transplantation
Abstract

During the 2019 novel coronavirus (SARS-CoV-2) outbreak in China (from January 24 to March 11, 2020), our center performed 16 organ transplants (10 kidney, 4 liver, and 2 lung transplants) harvested from deceased donors. Regarding the strategies to prevent infections of SARS-CoV-2, we implemented specific measures for the donor and recipient management, as well as prevention of hospital-acquired infections. All 16 organ recipients had a favorable outcome without SARS-CoV-2 infection. Our approaches aiming to interrupt the spread of SARS-CoV-2 within the transplantation wards were successful, and allowed us to maintain the transplantation program for deceased liver, kidney, and lung organ recipients.

Published
2020

127. Tumor necrosis factor-[alpha] in mechanic trauma plasma mediates cardiomyocyte apoptosis

Author

Li, Shuzhuang, Jiao, Xiangying, Tao, Ling, Liu, Huirong, Cao, Yue, Lopez, Bernard L., Christopher, Theodore A., and Ma, Xin L.

Subjects
Heart cells -- Research, Apoptosis -- Research, Blood plasma -- Research, Tumor necrosis factor -- Research, Cardiovascular research, Biological sciences
Abstract

Mechanical traumatic injury causes cardiomyocyte apoptosis and cardiac dysfunction. However, the signaling mechanisms leading to posttraumatic cardiomyocyte apoptosis remains unclear. The present study attempted to identify the molecular mechanisms responsible for cardiomyocyte apoptosis induced by trauma. Normal cardiomyocytes (NC) or traumatic cardiomyocytes (TC; isolated immediately after trauma) were cultured with normal plasma (NP) or traumatic plasma (TP; isolated 1.5 h after trauma) for 12 h, and apoptosis was determined by caspase-3 activation. Exposure of TC to NP failed to induce significant cardiomyocyte apoptosis. In contrast, exposure of NC to TP resulted in a greater than two-fold increase in caspase-3 activation (P < 0.01). Incubation of cardiomyocytes with cytomix (a mixture of TNF-[alpha], IL-1[beta], and IFN-[gamma]) or TNF-[alpha] alone, but not with IL-1[beta] or IFN-[gamma] alone, caused significant caspase-3 activation (P < 0.01). TP-induced caspase-3 activation was virtually abolished by an anti-TNF-[alpha] antibody, and TP isolated from TNF-[[alpha].sup.-/-] mice failed to induce caspase-3 activation. Moreover, incubation of cardiomyocytes with TP upregulated inducible nitric oxide (NO) synthase (iNOS)/NADPH oxidase expression, increased NO/superoxide production, and increased cardiomyocyte protein nitration (measured by nitrotyrosine content). These oxidative/ nitrative stresses and the resultant cardiomyocyte caspase-3 activation can be blocked by neutralization of TNF-[alpha] (anti-TNF-[alpha] antibody), inhibition of iNOS (1400W), or NADPH oxidase (apocynin) and scavenging of peroxynitrite (FP15) (P < 0.01). Taken together, our study demonstrated that there exists a TNF-[alpha]-initiated, cardiomyocyte iNOS/NADPH oxidase-dependent, peroxynitrite-mediated signaling pathway that contributes to posttraumatic myocardial apoptosis. Therapeutic interventions that block this signaling cascade may attenuate posttraumatic cardiac injury and reduce the incidence of secondary organ dysfunction after trauma. apoptosis; signal transduction; heart; cytokines

Published
2007

128. Cell Autophagy and Myocardial Ischemia/Reperfusion Injury

Author

Zhang, Suli, primary, Wang, Jin, additional, Du, Yunhui, additional, Shang, Jianyu, additional, Wang, Li, additional, Wang, Jie, additional, Wang, Ke, additional, Bai, Kehua, additional, Lv, Tingting, additional, Li, Xiao, additional, and Liu, Huirong, additional

Published
2013
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