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In recent years, business process re-engineering has played an important role in the development of large-scale web-based applications. To re-engineer business processes, business services are developed and coordinated by reusing a set of open APIs and services on the internet. Yet, the number of services on the internet has grown drastically, making it difficult for them to be discovered to support the changing business goals. One major challenge is therefore to search for a suitable service that matches a specific business goal from a large number of available services in an efficient and effective manner. To address this challenge, this paper proposes a deep learning approach for massive service discovery. The approach, thus called MassRAFF, employs a combination of the recurrent attention and feature fusion methods. This paper first presents the MassRAFF approach and then reports on an experiment for evaluating this approach. The experimental results show that the MassRAFF approach has performed reasonably well and has potential to be improved further in future work.

Innate immunity is the primary defense against viral infections, with Toll-like receptors (TLRs) playing a crucial role in this process. This study aims to highlight the effectiveness of a pyrrolo[3,2-d]pyrimidine derivative (named TLR713), a potential TLR7 agonist, in inhibiting pseudorabies virus (PRV) replication both in vitroand in vivo. Tests on PK-15 cells demonstrated that TLR713 had no significant impact on cell viability, cell cycle progression, or apoptosis at concentrations of 0 – 3 μmol L-1. TLR713 could promote the phosphorylation of IκBα, p38, and JNK through TLR7, and increase the expression of inflammatory cytokines. In vitro, when cells were treated with TLR713, PRV proliferation was inhibited via TLR7 pathway. Analysis of the viral life cycle indicated that TLR713 could inhibit the replication of PRV, but not affect viral attachment, entry, assembly, or release. In vivo, TLR713 showed no side effects on mice at a concentration of 25 mg kg-1. It improved the survival rate of PRV-infected mice, reduced tissue viral load, and alleviated the inflammatory response. In summary, this study highlights the potential of TLR713 as a novel TLR7 agonist capable of inhibiting PRV replication and may offer new opportunities for developing antiviral therapies.

Infection and aseptic loosening caused by bacteria and poor osseointegration remain serious challenges for orthopedic implants. The advanced surface modification of implants is an effective strategy for addressing these challenges. This study presents a “pneumatic nanocannon” coating for titanium orthopedic implants to achieve on-demand release of antibacterial and sustained release of osteogenic agents. SrTiO3nanotubes (SrNT) were constructed on the surface of Ti implants as “cannon barrel,” the “cannonball” (antibiotic) and “propellant” (NH4HCO3) were codeposited into SrNT with assistance of mussel-inspired copolymerization of dopamine and subsequently sealed by a layer of polydopamine. The encapsulated NH4HCO3within the nanotubes could be thermally decomposed into gases under near-infrared irradiation, propelling the on-demand delivery of antibiotics. This coating demonstrated significant efficacy in eliminating typical pathogenic bacteria both in planktonic and biofilm forms. Additionally, this coating exhibited a continuous release of strontium ions, which significantly enhanced the osteogenic differentiation of preosteoblasts. In an implant-associated infection rat model, this coating demonstrated substantial antibacterial efficiency (>99%) and significant promotion of osseointegration, along with alleviated postoperative inflammation. This pneumatic nanocannon coating presents a promising approach to achieving on-demand infection inhibition and sustained osseointegration enhancement for titanium orthopedic implants.

A configuration for an optical pumped monochromatic terahertz (THz) source operating in a high repetition rate is developed and based on a resonant parametric process within a Fabry–Perot microcavity. Comprehensive analysis of the spectral selection, cavity phase matching, energy-conversion dynamic, and input–output characteristics is provided. Calculations are performed on a Tm^3+-doped fiber laser pumped GaAs sheet. It is indicated that a pump threshold can be scaled down by injection seeding of the signal wave. Efficient THz wave generation (mW level average power) under relatively low pump peak power (65 kW) is predicted.