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368 results on '"Liu, Ruiting"'

101. CXCL16 protects against oxygen and glucose deprivation‐induced injury in human microvascular endothelial cells‐1: Potential role in ischemic stroke.

Author

Wang, Min and Liu, Ruiting

Subjects
*APOPTOSIS inhibition, *WESTERN immunoblotting, *GLUCOSE, *STROKE, *CELL survival
Abstract

Aim: To explore the protective effect of chemokine ligand 16 (CXCL16) against cell damage induced by oxygen‐glucose deprivation (OGD) in human microvascular endothelial cells‐1 (HMEC‐1) and its possible mechanism. Methods: Cell Counting Kit‐8 (CCK‐8) assay and flow cytometry were performed to determine cell viability and apoptosis of HMEC‐1, respectively. qRT‐PCR analysis was applied to display the expression of CXCL16 and miR‐424. Western blot analysis was used to detect the expression of apoptosis‐related proteins, CXCL16, cAMP/PKA/CREB, and PI3K–AKT–GSK3β pathway‐related proteins. Results: OGD significantly inhibited cell viability and promoted apoptosis. CXCL16 overexpression decreased the proliferation inhibition and apoptosis of HMEC‐1 induced by OGD. Furthermore, we found that CXCL16 was a target of miR‐424 and was downregulated by miR‐424. The further study showed that overexpression of miR‐424 significantly increased proliferation inhibition and apoptosis of HMEC‐1 induced by OGD. In addition, we also found that miR‐424 was downregulated by PMS2L2. In the subsequence experiment, overexpression of PMS2L2 significantly decreased the proliferation inhibition and apoptosis of HMEC‐1 induced by OGD, which suggested that PMS2L2 decreased cell damage of HMEC‐1 induced by OGD. Simultaneously, CXCL16 treatment markedly increased the phosphorylation of PKA/CREB and PI3K–AKT–GSK3β and these signal pathways were blocked by signal inhibitors. Conclusion: Our study first demonstrates that oxygen‐glucose deprivation (OGD)‐induced human microvascular endothelial cells‐1 (HMEC‐1) cell injury was alleviated by CXCL16 targeted by miR‐424 which further targeted by PMS2L2. This process might also be regulated by activating PKA/CREB and PI3K–AKT–GSK3β pathways. Highlights: 1.CXCL16 overexpression reduces OGD‐induced cell damage.2.CXCL16 is a target of miR‐424 and was downregulated by miR‐424.3.miR‐424 overexpression promotes OGD‐induced cell damage.4.miR‐424 is downregulated by PMS2L2.5.CXCL16 activates PKA/CREB and PI3K–AKT–GSK3β pathways. [ABSTRACT FROM AUTHOR]

Published
2019
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107. Chemical modulation of Kv7 potassium channels

Author

Borgini, Matteo, Mondal, Pravat, Liu, Ruiting, and Wipf, Peter

Abstract

The rising interest in Kv7 modulators originates from their ability to evoke fundamental electrophysiological perturbations in a tissue-specific manner. A large number of therapeutic applications are, in part, based on the clinical experience with two broad-spectrum Kv7 agonists, flupirtineand retigabine. Since precise molecular structures of human Kv7 channel subtypes in closed and open states have only very recently started to emerge, computational studies have traditionally been used to analyze binding modes and direct the development of more potent and selective Kv7 modulators with improved safety profiles. Herein, the synthetic and medicinal chemistry of small molecule modulators and the representative biological properties are summarized. Furthermore, new therapeutic applications supported by in vitroand in vivoassay data are suggested.

Published
2021
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114. Ultrathin Biomimetic Polymeric Ti3C2TxMXene Composite Films for Electromagnetic Interference Shielding

Author

Liu, Ruiting, Miao, Miao, Li, Yahui, Zhang, Jianfeng, Cao, Shaomei, and Feng, Xin

Abstract

Lightweight, ultrathin, and flexible electromagnetic interference (EMI) shielding materials with high electromagnetic shielding effectiveness (SE) and excellent mechanical robustness are greatly desired for miniaturized and highly integrated electronics. Herein, for the first time, a freestanding, ultrathin, and flexible Ti3C2Tx/poly(3,4-ethylenedioxythiophene)–poly(styrenesulfonate) (PEDOT:PSS) composite film with a “brick-and-mortar” structure is biomimetically designed and fabricated via a vacuum-assisted filtration process. The ultrathin polymeric composite film with a weight ratio 7:1 of Ti3C2Txto PEDOT:PSS is only 11.1 μm in thickness but exhibits a high EMI SE value of 42.10 dB. Meanwhile, the tensile strength increases considerably from 5.62 to 13.71 MPa and the corresponding ruptured strain increases from 0.18 to 0.29% compared with pure Ti3C2TxMXene film, respectively. Moreover, the hybrid film displays a superior conductivity of 340.5 S/cm and an outstanding specific EMI shielding efficiency of 19 497.8 dB cm2g–1. The superior electrical conductivity and specific EMI shielding efficiency imply the excellent potential of the Ti3C2Tx/PEDOT:PSS composite films for ultrathin, lightweight, and flexible EMI shielding materials.

Published
2018
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115. The scheme and achievement on CAD system for hydro-structure

Author

Liu Ruiting, Yang Baojun, and Wang Zong-min

Subjects
Engineering, Engineering drawing, Software portability, Hydraulic structure, business.industry, Sluice, Process (computing), ComputerApplications_COMPUTERSINOTHERSYSTEMS, CAD, Siphon, Hydraulic machinery, business, Steel bar
Abstract

Hydraulic structures were located in the wild environment, and the size and type of structure in each project are different. In addition, what designers need is efficient reinforcing steel bar CAD system, and how to solve this problem is the key of the success in hydraulic CAD system development. This refers to external taxonomy, and classifies the hydro-structures in detail, and acquires the system's efficiency utility at the cost of code repetition. In the paper, the authors propose the CAD system solutions about steel bar drawing of hydraulic structures, and realize the CAD system on invert siphon and sluice structure. In the end, the paper describes the inverted siphon structure as example to explain the system program architecture and implementation process. In the system, all of inverted siphon pipes, only box, and steel bar types have been classified by their type, and wrapped in many common classes, which is convenient for developing the system, also for the reusability and portability of the codes. The system realizes automated design for inverted siphon pipe, involving load input, internal force calculation, reinforcement calculation and steel-bar drawing plotting. It gives a method for CAD system development on hydraulic engineering.

Published
2011

149. A technique for laparoscopic extraperitoneal colostomy with an intact posterior sheath of rectus.

Author

Li, Zeyu, Tian, Lifei, Liu, Ruiting, Zheng, Bobo, Wang, Ben, Zhao, Xu, Quan, Pan, and Qiu, Jian

Abstract

Regardless of the advances in surgical techniques, parastomal hernia is still an inevitable complication for many patients with low rectal cancer undergoing abdominal perineal resection (APR). Extraperitoneal colostomy (EPC) seems to be a effective method to reduce the risk of parastomal hernia. We propose a new approach to simplify and standardize laparoscopic EPC to make this operation easy to perform. We used the technique of laparoscopic TEP groin hernia repair to produce an extraperitoneal tunnel, which can not only facilitate precise visualization of the extraperitoneal tunnel but also utilize the intact posterior rectus abdominis sheath as biologic materials to maintain soft-tissue augmentation, with a satisfactory result. With laparoscopy, we can create adequate space without insufficient dissection of the extraperitoneal tunnel while avoiding damage to the retrorectus sheath. At the time of writing, we had performed this method in four patients, without any complications. This technique is effective at preventing parastomal hernia without extra costs. [ABSTRACT FROM AUTHOR]

Published
2022
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