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102. Towards a common language in neurosurgical outcome evaluation: the NEON (NEurosurgical Outcome Network) proposal

Author

Ferroli, Paolo, Schiavolin, Silvia, Mariniello, Arianna, Acerbi, Francesco, Restelli, Francesco, Schiariti, Marco, LA Corte, Emanuele, Falco, Jacopo, Levi, Vincenzo, Dimeco, Francesco, Assietti, Roberto, Bongetta, Daniele, V Colombo, Elena, Bellocchi, Silvio, Sangiorgi, Simone, Bistazzoni, Simona, Polosa, Maria, I Orru, Maria, Spena, Giannantonio, Bernucci, Claudio, M Sicignano, Angelo, Fanti, Andrea, Brembilla, Carlo, Resmini, Bruno, Costi, Emanuele, Cenzato, Marco, Talamonti, Giuseppe, Bottini, Gabriella, Scarpa, Pina, Bollani, Alessandra, Querzola, Matteo, Palmas, Giulio, DE Gonda, Federico, Bosio, Lorenzo, Egidi, Marcello, Tardivo, Valentina, Fioravanti, Antonio, Subacchi, Sara, Fontanella, Marco, Biroli, Antonio, Cereda, Claudio, Paolo Panciani, Pier, Bergomi, Riccardo, Pertichetti, Marta, Tancioni, Flavio, Bona, Alberto, A Tartara, Fulvio, Fornari, Maurizio, Pessina, Federico, Lasio, Giovanni, Cardia, Andrea, Servadei, Franco, Riva, Marco, Casarotti, Alessandra, Giussani, Carlo, Fiori, Leonardo, Mazzoleni, Fabio, Vaiani, Simona, Carrabba, Giorgio, DI Cristofori, Andrea, P Sganzerla, Erik, Vimercati, Alberto, Isella, Valeria, Mauri, Ilaria, Incerti, Michele, Sicuri, Giovanni, Miramonti, Valentina, Stefini, Roberto, Spagnoli, Diego, Piparo, Maurizio, Grimod, Gianluca, Regazzoni, Rossana, Vismara, Daniela, Mazzeo, Lucio, Monti, Emanuele, Franzin, Alberto, Vivaldi, Oscar, Maietti, Alessandra, Pini, Elisa, Servello, Domenico, Zekaj, Edvin, DE Michele, Sara, Locatelli, Marco, Borsa, Stefano, Grimoldi, Nadia, Caroli, Manuela, Tariciotti, Leonardo, Abete-Fornara, Giorgia, Vitale, Mario, Leonardi, Matilde, Broggi, Morgan, Paolo Ferroli, Silvia Schiavolin, Arianna Mariniello, Francesco Acerbi, Francesco Restelli, Marco Schiariti, Emanuele LA Corte, Jacopo Falco, Vincenzo Levi, Francesco Dimeco, Roberto Assietti, Daniele Bongetta, Elena V Colombo, Silvio Bellocchi, Simone Sangiorgi, Simona Bistazzoni, Maria Polosa, Maria I Orru, Giannantonio Spena, Claudio Bernucci, Angelo M Sicignano, Andrea Fanti, Carlo Brembilla, Bruno Resmini, Emanuele Costi, Marco Cenzato, Giuseppe Talamonti, Gabriella Bottini, Pina Scarpa, Alessandra Bollani, Matteo Querzola, Giulio Palmas, Federico DE Gonda, Lorenzo Bosio, Marcello Egidi, Valentina Tardivo, Antonio Fioravanti, Sara Subacchi, Marco Fontanella, Antonio Biroli, Claudio Cereda, Pier Paolo Panciani, Riccardo Bergomi, Marta Pertichetti, Flavio Tancioni, Alberto Bona, Fulvio A Tartara, Maurizio Fornari, Federico Pessina, Giovanni Lasio, Andrea Cardia, Franco Servadei, Marco Riva, Alessandra Casarotti, Carlo Giussani, Leonardo Fiori, Fabio Mazzoleni, Simona Vaiani, Giorgio Carrabba, Andrea DI Cristofori, Erik P Sganzerla, Alberto Vimercati, Valeria Isella, Ilaria Mauri, Michele Incerti, Giovanni Sicuri, Valentina Miramonti, Roberto Stefini, Diego Spagnoli, Maurizio Piparo, Gianluca Grimod, Rossana Regazzoni, Daniela Vismara, Lucio Mazzeo, Emanuele Monti, Alberto Franzin, Oscar Vivaldi, Alessandra Maietti (ORCID:0000-0002-9819-7037), Elisa Pini, Domenico Servello, Edvin Zekaj, Sara DE Michele, Marco Locatelli, Stefano Borsa, Nadia Grimoldi, Manuela Caroli, Leonardo Tariciotti, Giorgia Abete-Fornara, Mario Vitale, Matilde Leonardi, Morgan Broggi, Ferroli, Paolo, Schiavolin, Silvia, Mariniello, Arianna, Acerbi, Francesco, Restelli, Francesco, Schiariti, Marco, LA Corte, Emanuele, Falco, Jacopo, Levi, Vincenzo, Dimeco, Francesco, Assietti, Roberto, Bongetta, Daniele, V Colombo, Elena, Bellocchi, Silvio, Sangiorgi, Simone, Bistazzoni, Simona, Polosa, Maria, I Orru, Maria, Spena, Giannantonio, Bernucci, Claudio, M Sicignano, Angelo, Fanti, Andrea, Brembilla, Carlo, Resmini, Bruno, Costi, Emanuele, Cenzato, Marco, Talamonti, Giuseppe, Bottini, Gabriella, Scarpa, Pina, Bollani, Alessandra, Querzola, Matteo, Palmas, Giulio, DE Gonda, Federico, Bosio, Lorenzo, Egidi, Marcello, Tardivo, Valentina, Fioravanti, Antonio, Subacchi, Sara, Fontanella, Marco, Biroli, Antonio, Cereda, Claudio, Paolo Panciani, Pier, Bergomi, Riccardo, Pertichetti, Marta, Tancioni, Flavio, Bona, Alberto, A Tartara, Fulvio, Fornari, Maurizio, Pessina, Federico, Lasio, Giovanni, Cardia, Andrea, Servadei, Franco, Riva, Marco, Casarotti, Alessandra, Giussani, Carlo, Fiori, Leonardo, Mazzoleni, Fabio, Vaiani, Simona, Carrabba, Giorgio, DI Cristofori, Andrea, P Sganzerla, Erik, Vimercati, Alberto, Isella, Valeria, Mauri, Ilaria, Incerti, Michele, Sicuri, Giovanni, Miramonti, Valentina, Stefini, Roberto, Spagnoli, Diego, Piparo, Maurizio, Grimod, Gianluca, Regazzoni, Rossana, Vismara, Daniela, Mazzeo, Lucio, Monti, Emanuele, Franzin, Alberto, Vivaldi, Oscar, Maietti, Alessandra, Pini, Elisa, Servello, Domenico, Zekaj, Edvin, DE Michele, Sara, Locatelli, Marco, Borsa, Stefano, Grimoldi, Nadia, Caroli, Manuela, Tariciotti, Leonardo, Abete-Fornara, Giorgia, Vitale, Mario, Leonardi, Matilde, Broggi, Morgan, Paolo Ferroli, Silvia Schiavolin, Arianna Mariniello, Francesco Acerbi, Francesco Restelli, Marco Schiariti, Emanuele LA Corte, Jacopo Falco, Vincenzo Levi, Francesco Dimeco, Roberto Assietti, Daniele Bongetta, Elena V Colombo, Silvio Bellocchi, Simone Sangiorgi, Simona Bistazzoni, Maria Polosa, Maria I Orru, Giannantonio Spena, Claudio Bernucci, Angelo M Sicignano, Andrea Fanti, Carlo Brembilla, Bruno Resmini, Emanuele Costi, Marco Cenzato, Giuseppe Talamonti, Gabriella Bottini, Pina Scarpa, Alessandra Bollani, Matteo Querzola, Giulio Palmas, Federico DE Gonda, Lorenzo Bosio, Marcello Egidi, Valentina Tardivo, Antonio Fioravanti, Sara Subacchi, Marco Fontanella, Antonio Biroli, Claudio Cereda, Pier Paolo Panciani, Riccardo Bergomi, Marta Pertichetti, Flavio Tancioni, Alberto Bona, Fulvio A Tartara, Maurizio Fornari, Federico Pessina, Giovanni Lasio, Andrea Cardia, Franco Servadei, Marco Riva, Alessandra Casarotti, Carlo Giussani, Leonardo Fiori, Fabio Mazzoleni, Simona Vaiani, Giorgio Carrabba, Andrea DI Cristofori, Erik P Sganzerla, Alberto Vimercati, Valeria Isella, Ilaria Mauri, Michele Incerti, Giovanni Sicuri, Valentina Miramonti, Roberto Stefini, Diego Spagnoli, Maurizio Piparo, Gianluca Grimod, Rossana Regazzoni, Daniela Vismara, Lucio Mazzeo, Emanuele Monti, Alberto Franzin, Oscar Vivaldi, Alessandra Maietti (ORCID:0000-0002-9819-7037), Elisa Pini, Domenico Servello, Edvin Zekaj, Sara DE Michele, Marco Locatelli, Stefano Borsa, Nadia Grimoldi, Manuela Caroli, Leonardo Tariciotti, Giorgia Abete-Fornara, Mario Vitale, Matilde Leonardi, and Morgan Broggi

Abstract

BACKGROUNDː To achieve a consensus on the minimum set of outcome measures and predictors to be used in the neurosurgical practice and on the timing of outcome assessment. METHODSː A consensus building approach was employed. All neurosurgical departments in Lombardy (Italy) were invited to participate by the Fondazione IRCCS Istituto Neurologico Carlo Besta. Three workshops were organized during which a multidisciplinary group called Neurosurgical Outcome Network (NEON) was created and the methodology to select outcome measures, predictors, and timing of outcome assessment was established. Eight working groups were created for the different neurosurgical diseases (neuro-oncological, skull base, vascular, traumatic, spinal, peripheral nervous system, malformation, functional) and 8 workshops were organized to identify the outcome measures and predictors specific for each of the neurosurgical diseases based on the experts’ clinical practice and the existing literature. RESULTSː A total of 20 neurosurgical departments participated in this study. Specific outcome measures, predictors and the timing of outcome assessment were identified for each of the 8 neurosurgical diseases. Moreover, a list of variables common to all pathologies were identified by the NEON group as further data to be collected. CONCLUSIONSː A consensus on the minimum set of outcome measures and predictors and the timing of outcome assessments for 8 neurosurgical diseases was achieved by a group of neurosurgeons of the Lombardy region, called NEON. These sets could be used in future studies for a more homogeneous data collection and as a starting point to reach further agreement also at national and international level.

Published
2023

103. Towards a common language in neurosurgical outcome evaluation: the NEON (NEurosurgical Outcome Network) proposal

Author

Ferroli, P, Schiavolin, S, Mariniello, A, Acerbi, F, Restelli, F, Schiariti, M, LA Corte, E, Falco, J, Levi, V, Dimeco, F, Assietti, R, Bongetta, D, Colombo, E, Bellocchi, S, Sangiorgi, S, Bistazzoni, S, Polosa, M, Orru, M, Spena, G, Bernucci, C, Sicignano, A, Fanti, A, Brembilla, C, Resmini, B, Costi, E, Cenzato, M, Talamonti, G, Bottini, G, Scarpa, P, Bollani, A, Querzola, M, Palmas, G, DE Gonda, F, Bosio, L, Egidi, M, Tardivo, V, Fioravanti, A, Subacchi, S, Fontanella, M, Biroli, A, Cereda, C, Panciani, P, Bergomi, R, Pertichetti, M, Tancioni, F, Bona, A, Tartara, F, Fornari, M, Pessina, F, Lasio, G, Cardia, A, Servadei, F, Riva, M, Casarotti, A, Giussani, C, Fiori, L, Mazzoleni, F, Vaiani, S, Carrabba, G, DI Cristofori, A, Sganzerla, E, Vimercati, A, Isella, V, Mauri, I, Incerti, M, Sicuri, G, Miramonti, V, Stefini, R, Spagnoli, D, Piparo, M, Grimod, G, Regazzoni, R, Vismara, D, Mazzeo, L, Monti, E, Franzin, A, Vivaldi, O, Maietti, A, Pini, E, Servello, D, Zekaj, E, DE Michele, S, Locatelli, M, Borsa, S, Grimoldi, N, Caroli, M, Tariciotti, L, Abete-Fornara, G, Vitale, M, Leonardi, M, Broggi, M, Ferroli, Paolo, Schiavolin, Silvia, Mariniello, Arianna, Acerbi, Francesco, Restelli, Francesco, Schiariti, Marco, LA Corte, Emanuele, Falco, Jacopo, Levi, Vincenzo, Dimeco, Francesco, Assietti, Roberto, Bongetta, Daniele, Colombo, Elena V, Bellocchi, Silvio, Sangiorgi, Simone, Bistazzoni, Simona, Polosa, Maria, Orru, Maria I, Spena, Giannantonio, Bernucci, Claudio, Sicignano, Angelo M, Fanti, Andrea, Brembilla, Carlo, Resmini, Bruno, Costi, Emanuele, Cenzato, Marco, Talamonti, Giuseppe, Bottini, Gabriella, Scarpa, Pina, Bollani, Alessandra, Querzola, Matteo, Palmas, Giulio, DE Gonda, Federico, Bosio, Lorenzo, Egidi, Marcello, Tardivo, Valentina, Fioravanti, Antonio, Subacchi, Sara, Fontanella, Marco, Biroli, Antonio, Cereda, Claudio, Panciani, Pier Paolo, Bergomi, Riccardo, Pertichetti, Marta, Tancioni, Flavio, Bona, Alberto, Tartara, Fulvio A, Fornari, Maurizio, Pessina, Federico, Lasio, Giovanni, Cardia, Andrea, Servadei, Franco, Riva, Marco, Casarotti, Alessandra, Giussani, Carlo, Fiori, Leonardo, Mazzoleni, Fabio, Vaiani, Simona, Carrabba, Giorgio, DI Cristofori, Andrea, Sganzerla, Erik P, Vimercati, Alberto, Isella, Valeria, Mauri, Ilaria, Incerti, Michele, Sicuri, Giovanni, Miramonti, Valentina, Stefini, Roberto, Spagnoli, Diego, Piparo, Maurizio, Grimod, Gianluca, Regazzoni, Rossana, Vismara, Daniela, Mazzeo, Lucio, Monti, Emanuele, Franzin, Alberto, Vivaldi, Oscar, Maietti, Alessandra, Pini, Elisa, Servello, Domenico, Zekaj, Edvin, DE Michele, Sara, Locatelli, Marco, Borsa, Stefano, Grimoldi, Nadia, Caroli, Manuela, Tariciotti, Leonardo, Abete-Fornara, Giorgia, Vitale, Mario, Leonardi, Matilde, Broggi, Morgan, Ferroli, P, Schiavolin, S, Mariniello, A, Acerbi, F, Restelli, F, Schiariti, M, LA Corte, E, Falco, J, Levi, V, Dimeco, F, Assietti, R, Bongetta, D, Colombo, E, Bellocchi, S, Sangiorgi, S, Bistazzoni, S, Polosa, M, Orru, M, Spena, G, Bernucci, C, Sicignano, A, Fanti, A, Brembilla, C, Resmini, B, Costi, E, Cenzato, M, Talamonti, G, Bottini, G, Scarpa, P, Bollani, A, Querzola, M, Palmas, G, DE Gonda, F, Bosio, L, Egidi, M, Tardivo, V, Fioravanti, A, Subacchi, S, Fontanella, M, Biroli, A, Cereda, C, Panciani, P, Bergomi, R, Pertichetti, M, Tancioni, F, Bona, A, Tartara, F, Fornari, M, Pessina, F, Lasio, G, Cardia, A, Servadei, F, Riva, M, Casarotti, A, Giussani, C, Fiori, L, Mazzoleni, F, Vaiani, S, Carrabba, G, DI Cristofori, A, Sganzerla, E, Vimercati, A, Isella, V, Mauri, I, Incerti, M, Sicuri, G, Miramonti, V, Stefini, R, Spagnoli, D, Piparo, M, Grimod, G, Regazzoni, R, Vismara, D, Mazzeo, L, Monti, E, Franzin, A, Vivaldi, O, Maietti, A, Pini, E, Servello, D, Zekaj, E, DE Michele, S, Locatelli, M, Borsa, S, Grimoldi, N, Caroli, M, Tariciotti, L, Abete-Fornara, G, Vitale, M, Leonardi, M, Broggi, M, Ferroli, Paolo, Schiavolin, Silvia, Mariniello, Arianna, Acerbi, Francesco, Restelli, Francesco, Schiariti, Marco, LA Corte, Emanuele, Falco, Jacopo, Levi, Vincenzo, Dimeco, Francesco, Assietti, Roberto, Bongetta, Daniele, Colombo, Elena V, Bellocchi, Silvio, Sangiorgi, Simone, Bistazzoni, Simona, Polosa, Maria, Orru, Maria I, Spena, Giannantonio, Bernucci, Claudio, Sicignano, Angelo M, Fanti, Andrea, Brembilla, Carlo, Resmini, Bruno, Costi, Emanuele, Cenzato, Marco, Talamonti, Giuseppe, Bottini, Gabriella, Scarpa, Pina, Bollani, Alessandra, Querzola, Matteo, Palmas, Giulio, DE Gonda, Federico, Bosio, Lorenzo, Egidi, Marcello, Tardivo, Valentina, Fioravanti, Antonio, Subacchi, Sara, Fontanella, Marco, Biroli, Antonio, Cereda, Claudio, Panciani, Pier Paolo, Bergomi, Riccardo, Pertichetti, Marta, Tancioni, Flavio, Bona, Alberto, Tartara, Fulvio A, Fornari, Maurizio, Pessina, Federico, Lasio, Giovanni, Cardia, Andrea, Servadei, Franco, Riva, Marco, Casarotti, Alessandra, Giussani, Carlo, Fiori, Leonardo, Mazzoleni, Fabio, Vaiani, Simona, Carrabba, Giorgio, DI Cristofori, Andrea, Sganzerla, Erik P, Vimercati, Alberto, Isella, Valeria, Mauri, Ilaria, Incerti, Michele, Sicuri, Giovanni, Miramonti, Valentina, Stefini, Roberto, Spagnoli, Diego, Piparo, Maurizio, Grimod, Gianluca, Regazzoni, Rossana, Vismara, Daniela, Mazzeo, Lucio, Monti, Emanuele, Franzin, Alberto, Vivaldi, Oscar, Maietti, Alessandra, Pini, Elisa, Servello, Domenico, Zekaj, Edvin, DE Michele, Sara, Locatelli, Marco, Borsa, Stefano, Grimoldi, Nadia, Caroli, Manuela, Tariciotti, Leonardo, Abete-Fornara, Giorgia, Vitale, Mario, Leonardi, Matilde, and Broggi, Morgan

Abstract

Background: The aim of this study was to achieve a consensus on the minimum set of outcome measures and predictors to be used in the neurosurgical practice and on the timing of outcome assessment. Methods: A consensus building approach was employed. All neurosurgical departments in Lombardy (Italy) were invited to participate by the Carlo Besta Neurologic Institute IRCCS Foundation. Three workshops were organized during which a multidisciplinary group called Neurosurgical Outcome Network (NEON) was created and the methodology to select outcome measures, predictors, and timing of outcome assessment was established. Eight working groups were created for the different neurosurgical diseases (neuro-oncological, skull base, vascular, traumatic, spinal, peripheral nervous system, malformation, functional) and 8 workshops were organized to identify the outcome measures and predictors specific for each of the neurosurgical diseases based on the experts' clinical practice and the existing literature. Results: A total of 20 neurosurgical departments participated in this study. Specific outcome measures, predictors and the timing of outcome assessment were identified for each of the 8 neurosurgical diseases. Moreover, a list of variables common to all pathologies were identified by the NEON group as further data to be collected. Conclusions: A consensus on the minimum set of outcome measures and predictors and the timing of outcome assessments for 8 neurosurgical diseases was achieved by a group of neurosurgeons of the Lombardy region, called NEON. These sets could be used in future studies for a more homogeneous data collection and as a starting point to reach further agreement also at national and international level.

Published
2023

104. A Deep Learning Model for Preoperative Differentiation of Glioblastoma, Brain Metastasis, and Primary Central Nervous System Lymphoma: An External Validation Study

Author

Tariciotti, L, Ferlito, D, Caccavella, V, Di Cristofori, A, Fiore, G, Remore, L, Giordano, M, Remoli, G, Bertani, G, Borsa, S, Pluderi, M, Remida, P, Basso, G, Giussani, C, Locatelli, M, Carrabba, G, Tariciotti, Leonardo, Ferlito, Davide, Caccavella, Valerio M., Di Cristofori, Andrea, Fiore, Giorgio, Remore, Luigi G., Giordano, Martina, Remoli, Giulia, Bertani, Giulio, Borsa, Stefano, Pluderi, Mauro, Remida, Paolo, Basso, Gianpaolo, Giussani, Carlo, Locatelli, Marco, Carrabba, Giorgio, Tariciotti, L, Ferlito, D, Caccavella, V, Di Cristofori, A, Fiore, G, Remore, L, Giordano, M, Remoli, G, Bertani, G, Borsa, S, Pluderi, M, Remida, P, Basso, G, Giussani, C, Locatelli, M, Carrabba, G, Tariciotti, Leonardo, Ferlito, Davide, Caccavella, Valerio M., Di Cristofori, Andrea, Fiore, Giorgio, Remore, Luigi G., Giordano, Martina, Remoli, Giulia, Bertani, Giulio, Borsa, Stefano, Pluderi, Mauro, Remida, Paolo, Basso, Gianpaolo, Giussani, Carlo, Locatelli, Marco, and Carrabba, Giorgio

Abstract

(1) Background: Neuroimaging differentiation of glioblastoma, primary central nervous system lymphoma (PCNSL) and solitary brain metastasis (BM) represents a diagnostic and therapeutic challenge in neurosurgical practice, expanding the burden of care and exposing patients to additional risks related to further invasive procedures and treatment delays. In addition, atypical cases and overlapping features have not been entirely addressed by modern diagnostic research. The aim of this study was to validate a previously designed and internally validated ResNet101 deep learning model to differentiate glioblastomas, PCNSLs and BMs. (2) Methods: We enrolled 126 patients (glioblastoma: n = 64; PCNSL: n = 27; BM: n = 35) with preoperative T1Gd-MRI scans and histopathological confirmation. Each lesion was segmented, and all regions of interest were exported in a DICOM dataset. A pre-trained ResNet101 deep neural network model implemented in a previous work on 121 patients was externally validated on the current cohort to differentiate glioblastomas, PCNSLs and BMs on T1Gd-MRI scans. (3) Results: The model achieved optimal classification performance in distinguishing PCNSLs (AUC: 0.73; 95%CI: 0.62–0.85), glioblastomas (AUC: 0.78; 95%CI: 0.71–0.87) and moderate to low ability in differentiating BMs (AUC: 0.63; 95%CI: 0.52–0.76). The performance of expert neuro-radiologists on conventional plus advanced MR imaging, assessed by retrospectively reviewing the diagnostic reports of the selected cohort of patients, was found superior in accuracy for BMs (89.69%) and not inferior for PCNSL (82.90%) and glioblastomas (84.09%). (4) Conclusions: We investigated whether the previously published deep learning model was generalizable to an external population recruited at a different institution—this validation confirmed the consistency of the model and laid the groundwork for future clinical applications in brain tumour classification. This artificial intelligence-based model might represe

Published
2023

108. Vertebral Body Infarction after Transarterial Preoperative Embolization of a Vertebral Hemangioma.

Author

Fiore, Giorgio, Bertani, Giulio A., Tariciotti, Leonardo, Borsa, Stefano, Paolucci, Aldo, Taramasso, Lucia, Locatelli, Marco, and Pluderi, Mauro

Subjects
INFARCTION, SPINAL cord tumors, EMERGING infectious diseases, HEMANGIOMAS, CHRONIC pain, ENDOVASCULAR surgery
Abstract

Background Vertebral hemangioma resection can be a real challenge for spine surgeons, given the high potential of massive intraoperative bleeding. For this reason, preoperative transarterial embolization of this tumor is supported by the available literature. Here, we discuss our difficulties in interpreting an unusual clinical and radiologic picture related to the endovascular procedure. Methods and Results A 45-year-old man was referred to our department due to chronic back pain and progressive lower extremity weakness. Radiologic assessment was obtained by means of spinal computed tomography (CT) and magnetic resonance imaging (MRI), which showed an aggressive vertebral hemangioma in T7, compressing the spinal cord. The patient underwent a combined therapeutic approach consisting of preoperative transarterial embolization followed by tumor resection, spinal cord decompression, and posterior thoracic arthrodesis. The patient was dismissed with neither strength nor sensory deficits. Two weeks later, he returned to our department with fever. A new MRI demonstrated multiple areas of altered signal in almost all vertebral bodies from T6 down to the sacrum. After a deep diagnostic process, including new MRI and infectious disease evaluations, the definitive diagnosis of multiple vertebral bone infarction was suggested. Conclusion Vertebral infarctions are an extremely rare complication of spinal endovascular procedures. To our knowledge, this is the first case of multiple postembolization vertebral infarctions, without spinal cord involvement. This peculiarity was explained by the presence of direct anastomoses between a posterior intercostal artery and the underlying vertebral bodies. [ABSTRACT FROM AUTHOR]

Published
2023
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109. Structural connections of the centromedian nucleus of thalamus and their relevance for neuromodulation in generalized drug-resistant epilepsy: insight from a tractography study.

Author

Remore, Luigi G., Rifi, Ziad, Nariai, Hiroki, Eliashiv, Dawn S., Fallah, Aria, Edmonds, Benjamin D., Matsumoto, Joyce H., Salamon, Noriko, Tolossa, Meskerem, Wei, Wexin, Locatelli, Marco, Tsolaki, Evangelia C., and Bari, Ausaf A.

Subjects
THALAMUS, NEUROMODULATION, EPILEPSY, DEEP brain stimulation, ANALYSIS of variance
Abstract

Background: Epilepsy is a widespread neurologic disorder and almost one-third of patients suffer from drug-resistant epilepsy (DRE). Neuromodulation targeting the centromediannucleus of the thalamus (CM) has been showing promising results for patients with generalized DRE who are not surgical candidates. Recently, the effect of CM- deep brain stimulation (DBS) in DRE patients was investigated in the Electrical Stimulation of Thalamus for Epilepsy of Lennox–Gastaut phenotype (ESTEL) trial, a monocentric randomized-controlled study. The same authors described a 'cold-spot' and a 'sweet-spot', which are defined as the volume of stimulation in the thalamus yielding the least and the best clinical response, respectively. However, it remains unclear which structural connections may contribute to the anti-seizure effect of the stimulation. Objective: We investigated the differences in structural connectivity among CM, the sweet-spot and the cold-spot. Furthermore, we tried to validate our results in a cohort of DRE patients who underwent CM-DBS or CM-RNS (responsive neurostimulation). We hypothesized that the sweet-spot would share similar structural connectivity with responder patients. Methods: By using the software FMRIB Software Library (FSL), probabilistic tractography was performed on 100 subjects from the Human Connectome Project to calculate the probability of connectivity of the whole CM, the sweet-spot and the cold-spot to 45 cortical and subcortical areas. Results among the three seeds were compared with multivariate analysis of variance (MANOVA). Similarly, the structural connectivity of volumes of tissue activated (VTAs) from eight DRE patients was investigated. Patients were divided into responders and non-responders based on the degree of reduction in seizure frequency, and the mean probabilities of connectivity were similarly compared between the two groups. Results: The sweet-spot demonstrated a significantly higher probability of connectivity (p < 0.001) with the precentral gyrus, superior frontal gyrus, and the cerebellum than the whole CM and the cold-spot. Responder patients displayed a higher probability of connectivity with both ipsilateral (p = 0.011) and contralateral cerebellum (p = 0.04) than the non-responders. Conclusion: Cerebellar connections seem to contribute to the beneficial effects of CM-neuromodulation in patients with drug-resistant generalized epilepsy. [ABSTRACT FROM AUTHOR]

Published
2023
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110. Microgravità e disco intervertebrale: l'impatto delle condizioni ambientali della microgravità sulla biomeccanica della colonna vertebrale.

Author

Marfia, Giovanni, Navone, Stefania Elena, Guarnaccia, Laura, Garzia, Emanuele, Tondo, Pietro, Catamo, Leonardo, Morte, Giulio Della, Ligarotti, Gianfranco Kim, Campanella, Carmelo, Perelli, Pietro, Locatelli, Marco, Landolfi, Angelo, and Appiani, Giuseppe Ciniglio

Subjects
LUMBAR pain, INTERVERTEBRAL disk, SPACE flight, REDUCED gravity environments, HUMAN body
Abstract

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Published
2023

111. Energy Delivered by Subthalamic Deep Brain Stimulation for Parkinson Disease Correlates With Depressive Personality Trait Shift

Author

Mameli, Francesca, primary, Ruggiero, Fabiana, additional, Dini, Michelangelo, additional, Marceglia, Sara, additional, Prenassi, Marco, additional, Borellini, Linda, additional, Cogiamanian, Filippo, additional, Pirola, Elena, additional, Remore, Luigi Gianmaria, additional, Fiore, Giorgio, additional, Reitano, Maria Rita, additional, Maiorana, Natale, additional, Poletti, Barbara, additional, Locatelli, Marco, additional, Barbieri, Sergio, additional, Priori, Alberto, additional, and Ferrucci, Roberta, additional

Published
2023
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113. Safety and efficacy of propranolol for treatment of familial cerebral cavernous malformations (Treat_CCM): a randomised, open-label, blinded-endpoint, phase 2 pilot trial

Author

Lanfranconi, Silvia, primary, Scola, Elisa, additional, Meessen, Jennifer M T A, additional, Pallini, Roberto, additional, Bertani, Giulio A, additional, Al-Shahi Salman, Rustam, additional, Dejana, Elisabetta, additional, Latini, Roberto, additional, Abete Fornara, Giorgia, additional, Agnelli, Nicolò M., additional, Albanese, Alessio, additional, Awad, Issam, additional, Bagnati, Renzo, additional, Balconi, Giovanna, additional, Ballabio, Elena, additional, Beghi, Ettore, additional, Bernasconi, Roberto, additional, Bertani, Giulio A., additional, Besana, Silvia, additional, Blanda, Adriana, additional, Bossi, Chiara, additional, Bresolin, Nereo, additional, Buratti, Maria G., additional, Calabrese, Roberta, additional, Carriero, Maria R., additional, Castori, Marco, additional, Ciceri, Elisa F., additional, Ciurleo, Rossella, additional, Comi, Giacomo P., additional, Contarino, Valeria, additional, Conte, Giorgio, additional, D'Agruma, Leonardo, additional, D'Alessandris, Giorgio Q., additional, de Grazia, Ugo, additional, Di Bonaventura, Rina, additional, d'Orio, Piergiorgio, additional, Farago', Giuseppe, additional, Foresta, Andreana, additional, Fusco, Carmela, additional, Gaudino, Chiara, additional, Lampugnani, Maria G., additional, Lanno, Alessia, additional, Lazzaroni, Francesca, additional, Lee, Cornelia, additional, Locatelli, Marco, additional, Maggioni, Aldo P., additional, Magnusson, Peetra, additional, Malinverno, Matteo, additional, Mangiavacchi, Maurizio, additional, Mangraviti, Antonella, additional, Marino, Silvia, additional, Mazzola, Selene, additional, Nicolis, Enrico B., additional, Novelli, Deborah, additional, Ojeda Fernandez, Maria L., additional, Petracca, Antonio, additional, Pignotti, Fabrizio, additional, Pogliani, Simona, additional, Poloni, Marco, additional, Prelle, Alessandro, additional, Raggi, Pamela, additional, Raucci, Franca, additional, Regna-Gladin, Caroline, additional, Ronchi, Dario, additional, Scelzo, Emma, additional, Seyfried, Salim, additional, Simeone, Anna, additional, Sturiale, Carmelo L., additional, Tassi, Laura, additional, Tettamanti, Mauro, additional, Torri, Valter, additional, Tournier-Lasserve, Elisabeth, additional, Treglia, Rita, additional, Triulzi, Fabio M., additional, Ungaro, Celeste, additional, Ursi, Elison, additional, Valcamonica, Gloria, additional, Vasami', Antonella, additional, and Zarino, Barbara, additional

Published
2023
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115. A Deep Learning Model for Preoperative Differentiation of Glioblastoma, Brain Metastasis, and Primary Central Nervous System Lymphoma: An External Validation Study

Author

Tariciotti, Leonardo, primary, Ferlito, Davide, additional, Caccavella, Valerio M., additional, Di Cristofori, Andrea, additional, Fiore, Giorgio, additional, Remore, Luigi G., additional, Giordano, Martina, additional, Remoli, Giulia, additional, Bertani, Giulio, additional, Borsa, Stefano, additional, Pluderi, Mauro, additional, Remida, Paolo, additional, Basso, Gianpaolo, additional, Giussani, Carlo, additional, Locatelli, Marco, additional, and Carrabba, Giorgio, additional

Published
2022
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116. Brain tumours in the time of COVID-19: An online survey on patients’ disease experience in one Italian region

Author

Abete-Fornara, Giorgia, Mameli, Francesca, Ruggiero, Fabiana, Meessen, Jennifer, Blanda, Adriana, Ampollini, Antonella, Locatelli, Marco, Salmaggi, Andrea, Di Cristofori, Andrea, Mauri, Ilaria, and Caroli, Manuela

Subjects
Cancer Research, Oncology
Abstract

BackgroundSince the outbreak, in 2019, of COVID-19, the world has experienced marked changes in daily habits, partly reflecting the exceptional social restrictions and health measures adopted to contain the disease. All these measures significantly affected not only peoples’s daily lives and psychological well-being but also the possibility for the healthcare system to function properly. In this setting, brain tumour patients were at risk due to their higher physical and mental fragility and their need for regular care. The aim of the present study was to assess, using a self-reported online questionnaire, the patients’s perceptions regarding their disease experience.Materials and methodsWe developed an online anonymous self-report survey to assess patients’s disease experience during the pandemic. We investigated the impact of the COVID-19 pandemic on patients’s cancer care schedules, their psychological distress and emotions felt during the pandemic, their levels of worry about COVID-19, and their oncological conditions.Results107 patients answered our survey, most of them suffering from a glioma. Less than one-third of the sample had their appointments cancelled, delayed or converted into online visits due to the pandemic. Of the patients who answered the survey, 95% declared they were satisfied with their Institute’s oncological management. The feelings reported most often were peacefulness or anxiety/worry; the majority of the sample reported high levels of loneliness, which tended to increase with age, whilst the psychological distress was correlated with age and with having a recurrence of the disease. Half of the sample declared severe worry about their oncological condition, in particular subjects with a recurrence or who were receiving adjuvant therapies. Patients with recurrence tended to worry more about the possibility of contracting COVID-19, and its effects.ConclusionOur findings illustrate how fragile and in need of care patients with a brain tumour may be, especially those with more severe clinical conditions. These data may help boost healthcare professionals’s knowledge about brain tumour patients’s needs and fears, so as to be able to offer them a better hospital experience and improve their clinical management, while possibly also reducing the psychological burden on patients and their families.

Published
2023

122. The Phenomenology of Depression

Author

Fregna, Lorenzo, Locatelli, Marco, and Colombo, Cristina

Subjects
depression, phenomenology, melancholy, psychopathology
Abstract

The phenomenological method, characterized by the suspension of judgment (epoché), has helped analyzing the subjective experience of patients affected by mental disorders. Psychiatry, dealing with the human being itself in its complexity and unicity, is placed between the biological positivistic attempt, for which the symptoms of mental illness are a mere consequence of brain dysfunctions and the phenomenological-existential approach, inclined to consider the symptoms as meaningful phenomena of the person’s subjective experience. Eugène Minkowski, Ludwig Binswanger, Arthur Tatossian, Kimura Bin, Henri Maldiney and Hubertus Tellenbach are fundamental authors in the phenomenological psychopathology of depression; they described the alterations of the lived time, space, body and others experienced by the depressed. Starting from the main theoretical contributions of the authors, we will focus on the psychopathology and discuss the key themes of clinical depression: guilt, poverty and hypochondriasis. Finally we will focus on the typus melancholicus construct.

Published
2022

124. PMON171 DRD2 Agonist Cabergoline Abolished the Escape Mechanism Induced by mTOR Inhibitor Everolimus in Pituitary Neuroendocrine Tumoral Cells

Author

Mangili, Federica, primary, Esposito, Emanuela, additional, Treppiedi, Donatella, additional, Catalano, Rosa, additional, Marra, Giusy, additional, Muro, Genesio D, additional, Locatelli, Marco, additional, Lania, Andrea Gerardo, additional, Arosio, Maura, additional, Mantovani, Giovanna, additional, and Peverelli, Erika Maria, additional

Published
2022
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125. Deep brain stimulation for Parkinson's disease in practice: results of the survey by the Italian Neurosurgery Society

Author

MANCINI, Fabrizio, primary, GUZZI, Giusy, additional, CASTRIOTO, Corrado F., additional, CAVALLO, Michele A., additional, CONTI, Alfredo, additional, CONTI, Carlo, additional, DELLA TORRE, Attilio, additional, ESPOSITO, Felice, additional, IORIO, Giuseppina, additional, LANDI, Andrea, additional, LANOTTE, Michele, additional, LAVANO, Angelo, additional, LOCATELLI, Marco, additional, LONGHI, Michele, additional, MARRUZZO, Daniele, additional, MONDANI, Massimo, additional, MORACE, Roberta, additional, PELLIZZARI, Manuel, additional, PIACENTINO, Massimo, additional, PICOZZI, Piero, additional, ROMEO, Francesco, additional, SARRUBBO, Silvio, additional, SERVELLO, Domenico, additional, SOMMA, Teresa, additional, TREZZA, Andrea, additional, TRINGALI, Giovanni, additional, TUFO, Tommaso, additional, and RICCIUTI, Riccardo A., additional

Published
2022
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126. Mitochondrial fitness and cancer risk

Author

Kossenkov, Andrew V., primary, Milcarek, Andrew, additional, Notta, Faiyaz, additional, Jang, Gun-Ho, additional, Wilson, Julie M., additional, Gallinger, Steven, additional, Zhou, Daniel Cui, additional, Ding, Li, additional, Ghosh, Jagadish C., additional, Perego, Michela, additional, Morotti, Annamaria, additional, Locatelli, Marco, additional, Robert, Marie E., additional, Vaira, Valentina, additional, and Altieri, Dario C., additional

Published
2022
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128. Indication and eligibility of glioma patients for awake surgery: A scoping review by a multidisciplinary perspective

Author

Fiore, Giorgio, primary, Abete-Fornara, Giorgia, additional, Forgione, Arianna, additional, Tariciotti, Leonardo, additional, Pluderi, Mauro, additional, Borsa, Stefano, additional, Bana, Cristina, additional, Cogiamanian, Filippo, additional, Vergari, Maurizio, additional, Conte, Valeria, additional, Caroli, Manuela, additional, Locatelli, Marco, additional, and Bertani, Giulio Andrea, additional

Published
2022
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129. Diffusion tensor imaging, intra-operative neurophysiological monitoring and small craniotomy: Results in a consecutive series of 103 gliomas

Author

Carrabba, Giorgio, primary, Fiore, Giorgio, additional, Di Cristofori, Andrea, additional, Bana, Cristina, additional, Borellini, Linda, additional, Zarino, Barbara, additional, Conte, Giorgio, additional, Triulzi, Fabio, additional, Rocca, Alessandra, additional, Giussani, Carlo, additional, Caroli, Manuela, additional, Locatelli, Marco, additional, and Bertani, Giulio, additional

Published
2022
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130. Peri-lead edema and local field potential correlation in post-surgery subthalamic nucleus deep brain stimulation patients

Author

Prenassi, Marco, primary, Borellini, Linda, additional, Bocci, Tommaso, additional, Scola, Elisa, additional, Barbieri, Sergio, additional, Priori, Alberto, additional, Ferrucci, Roberta, additional, Cogiamanian, Filippo, additional, Locatelli, Marco, additional, Rampini, Paolo, additional, Vergari, Maurizio, additional, Pastore, Stefano, additional, Datola, Bianca, additional, and Marceglia, Sara, additional

Published
2022
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136. An Experimental Analysis of Undo in Ubiquitous Computing Environments

Author

Loregian, Marco, Locatelli, Marco P., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Sandnes, Frode Eika, editor, Zhang, Yan, editor, Rong, Chunming, editor, Yang, Laurence T., editor, and Ma, Jianhua, editor

Published
2008
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138. Active Coordination Artifacts in Collaborative Ubiquitous-Computing Environments

Author

Locatelli, Marco P., Loregian, Marco, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Schiele, Bernt, editor, Dey, Anind K., editor, Gellersen, Hans, editor, de Ruyter, Boris, editor, Tscheligi, Manfred, editor, Wichert, Reiner, editor, Aarts, Emile, editor, and Buchmann, Alejandro, editor

Published
2007
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144. Bidimensional Packing by Bilinear Programming

Author

Caprara, Alberto, Locatelli, Marco, Monaci, Michele, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Jünger, Michael, editor, and Kaibel, Volker, editor

Published
2005
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146. A Targeted Next-Generation Sequencing Panel to Genotype Gliomas

Author

Guarnaccia, Maria, primary, Guarnaccia, Laura, additional, La Cognata, Valentina, additional, Navone, Stefania Elena, additional, Campanella, Rolando, additional, Ampollini, Antonella, additional, Locatelli, Marco, additional, Miozzo, Monica, additional, Marfia, Giovanni, additional, and Cavallaro, Sebastiano, additional

Published
2022
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147. A Frailty-Adjusted Stratification Score to Predict Surgical Risk, Post-Operative, Long-Term Functional Outcome, and Quality of Life after Surgery in Intracranial Meningiomas

Author

Tariciotti, Leonardo, primary, Fiore, Giorgio, additional, Carapella, Sara, additional, Remore, Luigi Gianmaria, additional, Schisano, Luigi, additional, Borsa, Stefano, additional, Pluderi, Mauro, additional, Canevelli, Marco, additional, Marfia, Giovanni, additional, Caroli, Manuela, additional, Locatelli, Marco, additional, and Bertani, Giulio, additional

Published
2022
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148. Space flight and central nervous system: Friends or enemies? Challenges and opportunities for neuroscience and neuro‐oncology

Author

Marfia, Giovanni, primary, Navone, Stefania Elena, additional, Guarnaccia, Laura, additional, Campanella, Rolando, additional, Locatelli, Marco, additional, Miozzo, Monica, additional, Perelli, Pietro, additional, Della Morte, Giulio, additional, Catamo, Leonardo, additional, Tondo, Pietro, additional, Campanella, Carmelo, additional, Lucertini, Marco, additional, Ciniglio Appiani, Giuseppe, additional, Landolfi, Angelo, additional, and Garzia, Emanuele, additional

Published
2022
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150. DRD2 Agonist Cabergoline Abolished the Escape Mechanism Induced by mTOR Inhibitor Everolimus in Tumoral Pituitary Cells

Author

Mangili, Federica, primary, Esposito, Emanuela, additional, Treppiedi, Donatella, additional, Catalano, Rosa, additional, Marra, Giusy, additional, Di Muro, Genesio, additional, Barbieri, Anna Maria, additional, Locatelli, Marco, additional, Lania, Andrea G., additional, Mangone, Alessandra, additional, Spada, Anna, additional, Arosio, Maura, additional, Peverelli, Erika, additional, and Mantovani, Giovanna, additional

Published
2022
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