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104. Contributors

Author

Abe, Takato, primary, Adams, Harold P., additional, Adeoye, Opeolu, additional, Agarwal, Sachin, additional, Aguilar, Maria I., additional, Al-Khoury, Lama, additional, Arboix, Adrià, additional, Auer, Roland N., additional, Awad, Issam A., additional, Baird, Alison E., additional, Baltan, Selva, additional, Barnett, Henry J.M., additional, Batjer, H. Hunt, additional, Benavente, Oscar R., additional, Bendok, Bernard R., additional, Bershad, Eric M., additional, Binder, Jeffrey R., additional, Boulos, Alan S., additional, Bousser, Marie-Germaine, additional, Bova, Frank J., additional, Brainin, Michael, additional, Brisman, Jonathan L., additional, Brown, Wendy, additional, Brust, John C.M., additional, Canhão, Patrícia, additional, Caplan, Louis R., additional, Castellanos, Mar, additional, Chabriat, Hugues, additional, Chamorro, Angel, additional, Choi, Jae H., additional, Chopp, Michael, additional, Connolly, E. Sander, additional, Coull, Bruce M., additional, Cucchiara, Brett L., additional, Dalkara, Turgay, additional, Dani, Krishna A., additional, Dannenbaum, Mark J., additional, Dashti, Shervin R., additional, Davis, Patricia H., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, Day, Arthur L., additional, De Leo, Michael J., additional, del Zoppo, Gregory J., additional, Diedler, Jennifer, additional, Diener, Hans-Christoph, additional, Di Tullio, Marco R., additional, Dobkin, Bruce H., additional, Drake, Kendra, additional, Du, Rose, additional, Ducros, Anne, additional, Dzialowski, Imanuel, additional, Eddleman, Christopher S., additional, Elhammady, Mohamed Samy, additional, Elkind, Mitchell S.V., additional, Elliott, J. Paul, additional, Ferro, José M., additional, Findlay, J. Max, additional, Friedman, William A., additional, Furie, Karen L., additional, Furlan, Anthony J., additional, Geibprasert, Sasikhan, additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Larry B., additional, Gonzales, Nicole R., additional, Gounis, Matthew J., additional, Greenberg, Steven M., additional, Greer, David M., additional, Grotta, James C., additional, Hacke, Werner, additional, Hallenbeck, John, additional, Hamann, Gerhard F., additional, Hartmann, Andreas, additional, Hennerici, Michael, additional, Heros, Roberto C., additional, Higashida, Randall, additional, Homma, Shunichi, additional, Hongo, Kazuhiro, additional, Hopkins, L. Nelson, additional, Horiuchi, Tetsuyoshi, additional, Howard, George, additional, Howard, Virginia J., additional, Huddle, Daniel, additional, Iadecola, Costantino, additional, Joutel, Anne, additional, Jüttler, Eric, additional, Kakarla, Udaya K., additional, Kalafut, Mary A., additional, Kannel, William B., additional, Kase, Carlos S., additional, Kasner, Scott E., additional, Kaste, Markku, additional, Khaw, Alexander, additional, Kidwell, Chelsea S., additional, Kim, Helen, additional, Kim, Louis J., additional, Kim, Stanley H., additional, Klijn, Catharina J.M. (Karin), additional, Kobayashi, Shigeaki, additional, Komotar, Ricardo J., additional, Krings, Timo, additional, Kunz, Alexander, additional, Kurth, Tobias, additional, Lamy, Catherine, additional, Lazar, Ronald M., additional, Levy, Elad I., additional, Liebeskind, David S., additional, Lyden, Patrick D., additional, Markham, Joanne, additional, Marshall, Randolph S., additional, Martí-Vilalta, J.L., additional, Mas, Jean-Louis, additional, Mast, Henning, additional, Masuda, Junichi, additional, Mathers, Colin D., additional, Mayberg, Marc R., additional, Meairs, Stephen, additional, Mendelow, Alexander David, additional, Meschia, James F., additional, Miller, Alyson A., additional, Miyawaki, Takahiro, additional, Mocco, J, additional, Mohr, J.P., additional, Morcos, Jacques J., additional, Morgenstern, Lewis B., additional, Moskowitz, Michael A., additional, Nahed, Brian V., additional, Newell, David W., additional, Ofengeim, Dimitry, additional, Ogata, Jun, additional, Ogilvy, Christopher S., additional, Palesch, Yuko Y., additional, Pancioli, Arthur, additional, Park, Min S., additional, Pawlikowska, Ludmila, additional, Pile-Spellman, John, additional, Powers, William J., additional, Puetz, Volker, additional, Ransom, Bruce R., additional, Roine, Risto O., additional, Ruigrok, Ynte M., additional, Rundek, Tatjana, additional, Sacco, Ralph L., additional, Sattenberg, Ronald J., additional, Saver, Jeffrey L., additional, Savitz, Sean I., additional, Seshadri, Sudha, additional, Sharma, Jitendra, additional, Silverboard, Gerald, additional, Singhal, Aneesh B., additional, Sobey, Christopher G., additional, Spetzler, Robert F., additional, Stapf, Christian, additional, Starke, Robert M., additional, Stiefel, Michael F., additional, Strong, Kathleen, additional, Suarez, José I., additional, Sykora, Marek, additional, Tafreshi, Gilda, additional, Brugge, Karel ter, additional, Tilley, Barbara C., additional, Toni, Danilo, additional, Tournier-Lasserve, Elisabeth, additional, Vilela, Marcelo D., additional, von Kummer, Rüdiger, additional, Wakhloo, Ajay K., additional, Warach, Steven, additional, Weksler, Babette B., additional, Willey, Joshua Z., additional, Wintermark, Max, additional, Wolf, Philip A., additional, Woo, Daniel, additional, Yamaguchi, Takenori, additional, Yasaka, Masahiro, additional, Young, William L., additional, Zahuranec, Darin B., additional, Zazulia, Allyson R., additional, Zhang, Zheng Gang, additional, Zukin, R. Suzanne, additional, and Zweifler, Richard M., additional

Published
2011
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110. Lack of clinical significance of early ischemic changes on computed tomography in acute stroke. (Original Contribution)

Author

Patel, Suresh C., Levine, Steven R., Tilley, Barbara C., Grotta, James C., Lu, Mei, Frankel, Michael, Haley, E. Clarke Jr., Brott, Thomas C., Broderick, Joseph P., Horowitz, Steven, Lyden, Patrick D., Lewandowski, Christopher A., Marler, John R., and A. Welch, K. M.

Subjects
Stroke (Disease) -- Drug therapy, Tissue plasminogen activator -- Health aspects, Ischemia -- Health aspects
Abstract

Doctors should not withhold treatment with t-PA from stroke patients just because the patient has early ischemic changes in the brain as seen on a CT scan. Early ischemic changes means the stroke is still in progress, but a study of 616 stroke patients showed those with early ischemic changes can still benefit from t-PA treatment., Context The prevalence and clinical significance of early ischemic changes (ElCs) on baseline computed tomography (CT) scan of the head obtained within 3 hours of ischemic stroke are not established. Objective To determine the frequency and significance of EIC on baseline head CT scans in the National Institute of Neurological Disorders and Stroke (NINDS) rt-PA (recombinant tissue plasminogen activator) Stroke Trial. Design and Setting The original study, a randomized controlled trial, took place from January 1991 through October 1994 at 43 sites, during which CT images were obtained within 3 hours of symptom onset and prior to the initiation of rt-PA or placebo. For the current analysis, detailed reevaluation was undertaken after October 1994 of all baseline head CT scans with clinical data available pretreatment (blinded to treatment arm). Patients Of 624 patients enrolled in the trial, baseline CT scans were retrieved and reviewed for 616 (99%). Main Outcome Measures Frequency of EICs on baseline CT scans; association of EIC with other baseline variables; effect of EICs on deterioration at 24 hours ([greater than or equal to]4 points increase from the baseline National Institutes of Health Stroke Scale [NIHSS] score); clinical outcome (measured by 4 clinical scales) at 3 months, CT lesion volume at 3 months, death at 90 days; and symptomatic intracranial hemorrhage (ICH) within 36 hours of treatment. Results The prevalence of EIC on baseline CT in the combined rt-PA and placebo groups was 31% (n = 194). The EIC was significantly associated with baseline NIHSS score ([rho]=0.23; P Conclusions Our analysis suggests that EICs are prevalent within 3 hours of stroke onset and correlate with stroke severity. However, EICs are not independently associated with increased risk of adverse outcome after rt-PA treatment. Patients treated with rt-PA did better whether or not they had EICs, suggesting that EICs on CT scan are not critical to the decision to treat otherwise eligible patients with rt-PA within 3 hours of stroke onset.

Published
2001

119. Assessing Cerebrovascular Hemodynamics Using Transcranial Doppler in Patients with Mechanical Circulatory Support Devices

Author

Melmed, Kara R., primary, Schlick, Konrad H., additional, Rinsky, Brenda, additional, Dumitrascu, Oana M., additional, Volod, Oksana, additional, Nezhad, Mani, additional, Padrick, Matthew M., additional, Runyan, Carmelita, additional, Arabia, Francisco A., additional, Moriguchi, Jaime D., additional, Lyden, Patrick D., additional, and Song, Shlee S, additional

Published
2020
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128. Colaboradores

Author

Adams, Harold P., Jr., Adeoye, Opeolu, Albers, Gregory W., Alexandrov, Andrei V., Amin-Hanjani, Sepideh, An, Hongyu, Anderson, Craig S., Anrather, Josef, Aparicio, Hugo J., Arai, Ken, Aronowski, Jaroslaw, Atchaneeyasakul, Kunakorn, Audebert, Heinrich, Auer, Roland N., Awad, Issam A., Ay, Hakan, Baltan, Selva, Balu, Ramani, Behbahani, Mandana, Benavente, Oscar R., Bershad, Eric M., Berthaud, Jimmy V., Blackburn, Spiros L., Bonati, Leo H., Bösel, Julian, Bousser, Marie Germaine, Broderick, Joseph P., Brown, Martin M., Brown, Wendy, Brust, John C.M., Bushnell, Cheryl, Canhão, Patrícia, Caplan, Louis R., Carrión-Penagos, Julián, Castellanos, Mar, Caunca, Michelle R., Chabriat, Hugues, Chamorro, Angel, Chen, Jieli, Chen, Jun, Chopp, Michael, Christorforids, Greg, Connolly, E. Sander, Jr., Cramer, Steven C., Cucchiara, Brett L., Czap, Alexandra L., Dannenbaum, Mark J., Davis, Patricia H., Dawson, Ted M., Dawson, Valina L., Day, Arthur L., Silva, T. Michael De, Sousa, Diana Aguiar de, Del Brutto, Victor J., del Zoppo, Gregory J., Derdeyn, Colin P., Di Tullio, Marco R., Diener, Hans Christoph, Diringer, Michael N., Dobkin, Bruce H., Dzialowski, Imanuel, Elkind, Mitchell S.V., Elm, Jordan, Feigin, Valery L., Ferro, José Manuel, Field, Thalia S., Fischer, Marlene, Fornage, Myriam, Furie, Karen L., Garcia-Bonilla, Lidia, Giannotta, Steven L., Gobin, Y. Pierre, Goldberg, Mark P., Goldstein, Larry B., Gonzales, Nicole R., Greer, David M., Grotta, James C., Guo, Ruiming, Gutierrez, Jose, Harmel, Peter, Howard, George, Howard, Virginia J., Hwang, Jee-Yeon, Iadecola, Costantino, Jahan, Reza, Jickling, Glen C., Joutel, Anne, Kasner, Scott E., Katan, Mira, Kellner, Christopher P., Khan, Muhib, Kidwell, Chelsea S., Kim, Helen, Kim, Jong S., Kircher, Charles E., Krings, Timo, Krishnamurthi, Rita V., Kurth, Tobias, Lansberg, Maarten G., Levy, Elad I., Liebeskind, David S., Liew, Sook-Lei, Lin, David J., Lisle, Benjamin, Lo, Eng H., Lyden, Patrick D., Maki, Takakuni, Maragkos, Georgios A., Marosfoi, Miklos, McCullough, Louise D., Meckler, Jason M., Meschia, James Frederick, Messé, Steven R., Mocco, J, Mokin, Maxim, Mooney, Michael A., Morgenstern, Lewis B., Moskowitz, Michael A., Mullen, Michael T., Nägel, Steffen, Nedergaard, Maiken, Neira, Justin A., Newman, Sarah, Nicholson, Patrick J., Norrving, Bo, O’Donnell, Martin, Ofengeim, Dimitry, Ogata, Jun, Ogilvy, Christopher S., Orrù, Emanuele, Ortega-Gutiérrez, Santiago, Padrick, Matthew Maximillian, Parsha, Kaushik, Parsons, Mark, Patel, Neil V., Patel, Virendra I., Pawlikowska, Ludmila, Pérez, Adriana, Perez-Pinzon, Miguel A., Picard, John M., Polster, Sean P., Powers, William J., Puetz, Volker, Putaala, Jukka, Rabinovich, Margarita, Ransom, Bruce R., Roa, Jorge A., Rosenberg, Gary A., Rossitto, Christina P., Rundek, Tatjana, Russin, Jonathan J., Sacco, Ralph L., Safouris, Apostolos, Samaniego, Edgar A., Sansing, Lauren H., Satani, Nikunj, Sattenberg, Ronald J., Saver, Jeffrey L., Savitz, Sean I., Schmidt, Christian, Seshadri, Sudha, Sharma, Vijay K., Sharp, Frank R., Sheth, Kevin N., Siddiqi, Omar K., Singhal, Aneesh B., Sobey, Christopher G., Sommer, Clemens J., Spetzler, Robert F., Stapleton, Christopher J., Strickland, Ben A., Su, Hua, Suarez, José I., Takayama, Hiroo, Tarsia, Joseph, Tatlisumak, Turgut, Thomas, Ajith J., Thompson, John W., Tsivgoulis, Georgios, Tournier-Lasserve, Elizabeth, Vidal, Gabriel, Wakhloo, Ajay K., Weksler, Babette B., Willey, Joshua Z., Wintermark, Max, Wong, Lawrence K.S., Xi, Guohua, Xu, Jinchong, Yaghi, Shadi, Yamaguchi, Takenori, Yang, Tuo, Yasaka, Masahiro, Zahuranec, Darin B., Zhang, Feng, Zhang, John H., Zheng, Zhitong, Zukin, R. Suzanne, and Zweifler, Richard M.

Published
2023
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142. Disparate trends of atherosclerotic plaque evolution in stroke patients under 18-month follow-up: a 3D whole-brain magnetic resonance vessel wall imaging study.

Author

Xiao, Jiayu, Song, Shlee S, Schlick, Konrad H, Xia, Shuang, Jiang, Tao, Han, Tong, Jackson, Robert J, Diniz, Marcio A, Dumitrascu, Oana M, Maya, Marcel M, Lyden, Patrick D, Li, Debiao, Yang, Qi, and Fan, Zhaoyang

Abstract

Purpose: The trend of atherosclerotic plaque feature evolution is unclear in stroke patients with and without recurrence. We aimed to use three-dimensional whole-brain magnetic resonance vessel wall imaging to quantify the morphological changes of causative lesions during medical therapy in patients with symptomatic intracranial atherosclerotic disease. Methods: Patients with acute ischemic stroke attributed to intracranial atherosclerotic disease were retrospectively enrolled if they underwent both baseline and follow-up magnetic resonance vessel wall imaging. The morphological features of the causative plaque, including plaque volume, peak normalized wall index, maximum wall thickness, degree of stenosis, pre-contrast plaque-wall contrast ratio, and post-contrast plaque enhancement ratio, were quantified and compared between the non-recurrent and recurrent groups (defined as the recurrence of a vascular event within 18 months of stroke). Results: Twenty-nine patients were included in the final analysis. No significant differences were found in plaque features in the baseline scan between the non-recurrent (n = 22) and recurrent groups (n = 7). The changes in maximum wall thickness (–13.32% vs. 8.93%, P = 0.026), plaque-wall contrast ratio (–0.82% vs. 3.42%, P = 0.005) and plaque enhancement ratio (–11.03% vs. 9.75%, P = 0.019) were significantly different between the non-recurrent and recurrent groups. Univariable logistic regression showed that the increase in plaque-wall contrast ratio (odds ratio 3.22, 95% confidence interval 1.55–9.98, P = 0.003) was related to stroke recurrence. Conclusion: Morphological changes of plaque features on magnetic resonance vessel wall imaging demonstrated distinct trends in symptomatic intracranial atherosclerotic disease patients with and without stroke recurrence. [ABSTRACT FROM AUTHOR]

Published
2022
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144. Contributors

Author

Acharya, Aninda B., primary, Adams, Harold P., additional, Al-Khoury, Lama, additional, Arboix, Adria, additional, Auer, Roland N., additional, Awad, Issam A., additional, Baird, Alison E., additional, Barnett, Henry J.M., additional, Benavente, Oscar, additional, Bendok, Bernard R., additional, Binder, Jeffrey R., additional, Bogousslavsky, Julien, additional, Boulos, Alan S., additional, Bousser, Marie-Germaine, additional, Brainin, Michael, additional, Brey, Robin L., additional, Broderick, Joseph P., additional, Brust, John C.M., additional, Calderone, Agata, additional, Caplan, Louis R., additional, Chabriat, H., additional, Chamorro, Angel, additional, Cho, Sunghee, additional, Choi, Dennis W., additional, Coull, Bruce M., additional, Cunningham, Edward J., additional, Dalkara, Turgay, additional, Davis, Patricia H., additional, Davis, Stephen M., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, del Zoppo, Gregory J., additional, Diener, H.C., additional, Di Tullio, Marco R., additional, Dobkin, Bruce H., additional, Donnan, Geoffrey A., additional, Elkind, Mitchell S.V., additional, Elliott, J. Paul, additional, Erkinjuntti, Timo, additional, Faraci, Frank M., additional, Feuerstein, Giora, additional, Findlay, J. Max, additional, Fleetwood, Ian G., additional, Furie, Karen L., additional, Furlan, Anthony J., additional, Gautier, Jean Claude, additional, Georgiadis, Dimitrios, additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Steven, additional, Greenberg, Steven M., additional, Grotta, James C., additional, Grubb, Robert L., additional, Guterman, Lee R., additional, Hacke, Werner, additional, Hallenbeck, John, additional, Hammann, Gerhard F., additional, Hartmann, Andreas, additional, Hashi, Kazuo, additional, Heistad, Donald D., additional, Hennerici, Michael, additional, Hernesniemi, Juha, additional, Hier, Daniel B., additional, Higashida, Randall T., additional, Homma, Shunichi, additional, Hongo, Kazuhiro, additional, Hopkins, L. Nelson, additional, Howard, George, additional, Howard, Virginia, additional, Huddle, Daniel, additional, Hupperts, Raymond M.M., additional, Iadecola, Costantino, additional, Infeld, Bernard, additional, Iyer, Sriram S., additional, Joutel, A., additional, Jover, Teresa, additional, Jungreis, Charles A., additional, Kalafut, Mary A., additional, Kase, Carlos S., additional, Kasner, Scott E., additional, Kaste, Markku, additional, Kidwell, Chelsea S., additional, Kim, Louis J., additional, Kim, Stanley H., additional, Kistler, J. Philip, additional, Kobayashi, Shigeaki, additional, Labiche, Lise A., additional, Lamy, Catherine, additional, Lau, C. Geoff, additional, Lawton, Michael T., additional, Lazar, Ronald M., additional, Lemole, G. Michael, additional, Le Roux, Peter D., additional, Levy, Elad I., additional, Lodder, Jan, additional, Lyden, Patrick D., additional, Ma, H., additional, Macdonald, R. Loch, additional, Maeder, Philippe, additional, Marchak, B. Elaine, additional, Markham, Joanne, additional, Marshall, Randolph S., additional, Marti-Vilalta, J.L., additional, Mas, Jean-Louis, additional, Mast, Henning, additional, Masuda, Junichi, additional, Mayberg, Marc R., additional, Meairs, Stephen, additional, Mendelow, Alexander David, additional, Mohr, J.P., additional, Morgenstern, Lewis B., additional, Moskowitz, Michael A., additional, Nitta, Junpei, additional, Ogata, Jun, additional, Oyelese, Adetokunbo A., additional, Palesch, Yuko Y., additional, Pancioli, Arthur M., additional, Parsa, Andrew T., additional, Piechowski-Jóźwiak, Bartlomiej, additional, Pile-Spellman, John, additional, Powers, William J., additional, Qureshi, Adnan I., additional, Ransom, Bruce R., additional, Riina, Howard A., additional, Roine, Risto O., additional, Ronkainen, Antti, additional, Roubin, Gary S., additional, Rundek, Tanja, additional, Sacco, Ralph L., additional, Sattenberg, Ronald J., additional, Saver, Jeffrey, additional, Schumacher, Herrmann-Christian, additional, Schwab, Stefan, additional, Sherman, David G., additional, Silverboard, Gerald, additional, Simionescu, Monica, additional, Sobey, Christopher G., additional, Solomon, Robert A., additional, Spetzler, Robert F., additional, Stapf, Christian, additional, Steinberg, Gary K., additional, Sudlow, Cathie, additional, Tilley, Barbara C., additional, Toni, Danilo, additional, Tournier-Lasserve, E., additional, Vahedi, K., additional, Vates, G. Edward, additional, Vitek, Jiri J., additional, Wanibuchi, Masahiko, additional, Warach, Steven, additional, Warlow, Charles P., additional, Weir, Bryce, additional, Weisz, Giora, additional, Weksler, Babette B., additional, Welch, K. M.A., additional, Winn, H. Richard, additional, Wolf, Philip A., additional, Xavier, Andrew R., additional, Yahia, Abutaher M., additional, Yamaguchi, Takenori, additional, Yamaura, Akira, additional, Yokota, Hidenori, additional, Zabramski, Joseph M., additional, Zazulia, Allyson R., additional, Zukin, R. Suzanne, additional, and Zweifler, Richard M., additional

Published
2004
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147. Guidelines for the Early Management of Adults With Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists.

Author

Adams, Harold P., Jr, del Zoppo, Gregory, Alberts, Mark J., Bhatt, Deepak L., Brass, Lawrence, Furlan, Anthony, Grubb, Robert L., Higashida, Randall T., Jauch, Edward C., Kidwell, Chelsea, Lyden, Patrick D., Morgenstern, Lewis B., Qureshi, Adnan I., Rosenwasser, Robert H., Scott, Phillip A., and Wijdicks, Eelco F.M.

Published
2007
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