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101. Scope of consent

Author

Lynch, Jane, primary, Terry, Louise M, additional, Battersby, Sue, additional, and Smith, Colum J, additional

Published
2010
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103. The legal process

Author

Lynch, Jane, primary, Terry, Louise M, additional, Battersby, Sue, additional, and Smith, Colum J, additional

Published
2010
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106. Documenting consent

Author

Lynch, Jane, primary, Terry, Louise M, additional, Battersby, Sue, additional, and Smith, Colum J, additional

Published
2010
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117. Capacity

Author

Lynch, Jane, primary, Terry, Louise M, additional, Battersby, Sue, additional, and Smith, Colum J, additional

Published
2010
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118. Relatives’ rights

Author

Lynch, Jane, primary, Terry, Louise M, additional, Battersby, Sue, additional, and Smith, Colum J, additional

Published
2010
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119. Informed consent

Author

Lynch, Jane, primary, Terry, Louise M, additional, Battersby, Sue, additional, and Smith, Colum J, additional

Published
2010
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123. Contributors

Author

Agnese, Doreen, primary, Allen, Kathleen Gardiner, additional, Ashfaq, Raheela, additional, Aversano, Thomas R., additional, Barsky, Sanford H., additional, Bassett, Lawrence W., additional, Beahm, Elisabeth K., additional, Beenken, Samuel W., additional, Bermas, Honnie R., additional, Bevers, Therese B., additional, Birru, Mehret, additional, Bland, Kirby I., additional, Brewster, Abenaa M., additional, Brinton, Louise A., additional, Brock, Malcolm V., additional, Brooks, Mai N., additional, Buchholz, Thomas A., additional, Chang, Helena R., additional, Chera, Bhishamjit S., additional, Ching, C. Denise, additional, Chung, Maureen A., additional, Cody, Hiram S., additional, Copeland, Edward M., additional, Cox, Charles E., additional, Cristofanilli, Massimo, additional, Curiel, David T., additional, Cuttino, Laurie W., additional, de la Torre, Jorge I., additional, De Los Santos, Jennifer F., additional, Diab, Mohammad S., additional, Disis, Mary L., additional, Dooley, William C., additional, DuPont, William D., additional, Dutt, Philip L., additional, Eberlein, Timothy J., additional, Edgerton, Mary, additional, El-Tamer, Mahmoud, additional, Farrar, William B., additional, Fearmonti, Regina M., additional, Folkman, M. Judah, additional, Freedman, Gary M., additional, Frykberg, Eric R., additional, Gaskin, Thomas A., additional, Gemignani, Mary, additional, Gillanders, William E., additional, Giuliano, Armando E., additional, Goedegebuure, Peter S., additional, Gold, Julie, additional, Golshan, Mehra, additional, Gradishar, William J., additional, Grobmyer, Stephen R., additional, Grube, Baiba J., additional, Harichand-Herdt, Seema, additional, Harper, J. Garrett, additional, Hasan, Yasmin, additional, Hohenhaus, Mary H., additional, Hortobagyi, Gabriel N., additional, Howard, J. Harrison, additional, Hsu, Christopher P., additional, Hudson, Alana G., additional, Hunt, Kelly K., additional, Ioan, Anamaria, additional, Jimenez, Rafael E., additional, Johnson, Joyce E., additional, Kaklamani, Virginia G., additional, Karam, Amer, additional, Karlin, Nina J., additional, Kass, Rena B., additional, Kaur, Paramjeet, additional, Kern, Kenneth A., additional, Khan, Seema A., additional, Kiluk, John V., additional, Kim, Paula, additional, Kirwan, Jessica, additional, Klimberg, V. Suzanne, additional, Klobocista, Merieme, additional, Kort, Kara C., additional, Krontiras, Helen, additional, Kruse, E. James, additional, Kuerer, Henry, additional, Lee, Jane W., additional, Leitch, A. Marilyn, additional, Le-Petross, Huong T., additional, Lightsey, Judith L., additional, Ligibel, Jennifer A., additional, Lind, D. Scott, additional, Lipkowitz, Stanley, additional, Long, James N., additional, Love, Richard, additional, Lu, Hailing, additional, Lynch, Henry T., additional, Lynch, Jane, additional, Mahoney, Mary, additional, Mancino, Anne T., additional, Marcus, Joseph N., additional, Marks, Lawrence B., additional, Masood, Shahla, additional, Massoll, Nicole, additional, McCraw, John B., additional, McLoughlin, James, additional, Meguid, Michael M., additional, Mendenhall, Nancy P., additional, Mendenhall, William M., additional, Mendez, Jane, additional, Middleton, Lavinia P., additional, Miller, Michael J., additional, Moore-Higgs, Giselle J., additional, Moulton, Anne W., additional, Mrozek, Ewa, additional, Nabell, Lisle, additional, Nam, Jiho, additional, Niederhuber, John E., additional, Numann, Patricia J., additional, Oler, Albert, additional, O'Regan, Ruth, additional, Page, David L., additional, Palazzo, Juan P., additional, Partridge, Ann H., additional, Peters, Sara B., additional, Hoang Pham, John Dung, additional, Phan, Vy, additional, Pollock, Raphael E., additional, Port, Elisa R., additional, Potter, David, additional, Povoski, Stephen P., additional, Prati, Raquel, additional, Press, Michael F., additional, Price, Janet E., additional, Puleo, Christopher A., additional, Recht, Abram, additional, Reeves, Katherine W., additional, Reuben, James M., additional, Romrell, Lynn J., additional, Rosenbloom, Arlan L., additional, Rubinstein, Wendy S., additional, Ruddy, Kathryn J., additional, Sanfilippo, Kristen, additional, Santillan, Alfredo A., additional, Schwartz, Gordon F., additional, Shah, Heather, additional, Shapiro, Charles, additional, Shen, Angela, additional, Shirazi, Sherin, additional, Shyr, Yu, additional, Silverstein, Melvin J., additional, Simpson, Jean F., additional, Singletary, S. Eva, additional, Smith, Benjamin D., additional, Snead, Felicia E., additional, Snyder, Carrie L., additional, Strong, Theresa V., additional, Styblo, Toncred M., additional, Urist, Marshall M., additional, Uttarwar, Mohan, additional, Vasconez, Luis O., additional, Vicini, Frank A., additional, Vogel, Victor G., additional, Wakely, Paul E., additional, Wall, Terry J., additional, Wicha, Max, additional, Winchester, David J., additional, Winchester, David P., additional, Winer, Eric P., additional, Wood, William C., additional, Yee, Douglas, additional, Yung, Rex C.W., additional, and Zelnak, Amelia, additional

Published
2009
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126. Acanthosis nigricans as a composite marker of cardiometabolic risk and its complex association with obesity and insulin resistance in Mexican American children

Author

Lopez-Alvarenga, Juan C., primary, Chittoor, Geetha, additional, Paul, Solomon F. D., additional, Puppala, Sobha, additional, Farook, Vidya S., additional, Fowler, Sharon P., additional, Resendez, Roy G., additional, Hernandez-Ruiz, Joselin, additional, Diaz-Badillo, Alvaro, additional, Salazar, David, additional, Garza, Doreen D., additional, Lehman, Donna M., additional, Mummidi, Srinivas, additional, Arya, Rector, additional, Jenkinson, Christopher P., additional, Lynch, Jane L., additional, DeFronzo, Ralph A., additional, Blangero, John, additional, Hale, Daniel E., additional, and Duggirala, Ravindranath, additional

Published
2020
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139. Effects of Metabolic Factors, Race-Ethnicity, and Sex on the Development of Nephropathy in Adolescents and Young Adults With Type 2 Diabetes: Results From the TODAY Study.

Author

BjornstadPetterEl ghormliLaureHughanKara S.LaffelLori M.NadeauKristen J.RayasMariaTesfaldetBereketTollefsenSherida E.WilliSteven M.LynchJane, Bjornstad, Petter, El ghormli, Laure, Hughan, Kara S., Laffel, Lori M., Nadeau, Kristen J., Rayas, Maria, Tesfaldet, Bereket, Tollefsen, Sherida E., Willi, Steven M., Lynch, Jane, and TODAY Study Group

Abstract

Objective: To describe the longitudinal effects of sex, race-ethnicity, and metabolic factors on the risk of developing diabetic kidney disease (DKD) in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) cohort.Research Design and Methods: Urine albumin-to-creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) by serum creatinine and cystatin C were assessed annually for up to 15 years after study entry. Markers of DKD included micro- and macroalbuminuria (UACR ≥30 mg/g and ≥300 mg/g, respectively), hyperfiltration (eGFR ≥135 mL/min/1.73 m2), and rapid eGFR annual decline (>3 mL/min/1.73 m2 and/or ≥3.3%). The relationships between risk factors and DKD were evaluated longitudinally using time-to-event models.Results: Data were available on 677 participants, average age at baseline 14 years, with a mean ± SD follow-up of 10.2 ± 4.5 years. Each 1% increment in HbA1c conferred higher risk of microalbuminuria (hazard ratio 1.24 [95% CI 1.18, 1.30]), macroalbuminuria (1.22, [1.11, 1.34]), hyperfiltration (1.11, [1.05, 1.17]), and rapid eGFR decline (1.12, [1.04, 1.20]). Higher systolic blood pressure and baseline serum uric acid, and lower indices of β-cell function (C-peptide index and oral disposition index [oDI]), increased the risk of microalbuminuria, while higher triglycerides increased risk of micro- and macroalbuminuria. Lower oDI levels, female sex, and Hispanic ethnicity were associated with higher risk of hyperfiltration.Conclusions: Elevated HbA1c was a shared risk factor among all phenotypes of DKD in this longitudinal cohort of adolescents and young adults with youth-onset type 2 diabetes. Other risk factors included elevated blood pressure, triglycerides, serum uric acid, and β-cell dysfunction. [ABSTRACT FROM AUTHOR]

Published
2022
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146. Liraglutide in children and adolescents with type 2 diabetes

Author

Tamborlane, William V, Barrientos-Pérez, Margarita, Fainberg, Udi, Frimer-Larsen, Helle, Hafez, Mona, Hale, Paula M, Jalaludin, Muhammad Y, Kovarenko, Margarita, Libman, Ingrid, Lynch, Jane L, Rao, Paturi, Shehadeh, Naim, Turan, Serap, Weghuber, Daniel, Barrett, Timothy, Ellipse Trial Investigators, Lysy, Philippe, Beauloye, Véronique, Clinical sciences, Biology of the Testis, Pediatrics, Growth and Development, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, and UCL - (SLuc) Unité d'endocrinologie pédiatrique

Subjects
Blood Glucose, Male, Pediatrics, medicine.medical_specialty, Glycated Hemoglobin A, Adolescent, Gastrointestinal Diseases, Liraglutide/administration & dosage, Disease, Type 2 diabetes, 030204 cardiovascular system & hematology, law.invention, Glycated Hemoglobin A/analysis, Hypoglycemic Agents/adverse effects, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, Randomized controlled trial, Double-Blind Method, law, Diabetes mellitus, Hypoglycemic Agents, Insulin, Humans, Medicine, 030212 general & internal medicine, Child, Metformin/adverse effects, Glycemic, Medicine(all), Dose-Response Relationship, Drug, business.industry, Liraglutide, Gastrointestinal Diseases/chemically induced, General Medicine, Blood Glucose/analysis, medicine.disease, Metformin, Diabetes Mellitus, Type 2, Insulin/therapeutic use, Drug Therapy, Combination, Female, Diabetes Mellitus, Type 2/blood, business, medicine.drug
Abstract

BACKGROUND: Metformin is the regulatory-approved treatment of choice for most youth with type 2 diabetes early in the disease. However, early loss of glycemic control has been observed with metformin monotherapy. Whether liraglutide added to metformin (with or without basal insulin treatment) is safe and effective in youth with type 2 diabetes is unknown. METHODS: Patients who were 10 to less than 17 years of age were randomly assigned, in a 1:1 ratio, to receive subcutaneous liraglutide (up to 1.8 mg per day) or placebo for a 26-week double-blind period, followed by a 26-week open-label extension period. Inclusion criteria were a body-mass index greater than the 85th percentile and a glycated hemoglobin level between 7.0 and 11.0% if the patients were being treated with diet and exercise alone or between 6.5 and 11.0% if they were being treated with metformin (with or without insulin). All the patients received metformin during the trial. The primary end point was the change from baseline in the glycated hemoglobin level after 26 weeks. Secondary end points included the change in fasting plasma glucose level. Safety was assessed throughout the course of the trial. RESULTS: Of 135 patients who underwent randomization, 134 received at least one dose of liraglutide (66 patients) or placebo (68 patients). Demographic characteristics were similar in the two groups (mean age, 14.6 years). At the 26-week analysis of the primary efficacy end point, the mean glycated hemoglobin level had decreased by 0.64 percentage points with liraglutide and increased by 0.42 percentage points with placebo, for an estimated treatment difference of -1.06 percentage points (P

Published
2019
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149. Investigational strategies for detection and intervention in early-stage pancreatic cancer: A meeting organized by national cancer institute, organ systems program, division of cancer biology, diagnosis, and centers, April 24–27, Annapolis, MD

Author

Longnecker, Daniel S., Pour, Parviz M., Scarpelli, Dante G., Caldas, Carlos, Redston, Mark S., Hahn, Stephan A., Seymour, Albert B., Hruban, Ralph H., Yeo, Charles J., Kern, Scott E., Ruggeri, B. A., Klein-Szanto, A. J. P., Huang, L. -Y., Lang, D., Andr’en-Sandberg, Åke, Johansson, Bertil, Sandgren, Eric P., Klöppel, Günter, Longnecker, Daniel S., Ghadirian, P., Howe, G. R., Howard, John M., Lynch, Henry T., Fusaro, LaVonne, Fusaro, Ramon, Lynch, Jane, Smyrk, Thomas, Andr’en-Sandberg, Åke, Fusaro, Ramon M., Lynch, Henry T., Günter Klöppel, Rao, M. Sambasiva, Reddy, Janardan K., Albores-Saavedra, Jorge, Milchgrub, Sara, Donald E. Henson, Klimstra, David S., Hameed, Meera R., Marrero, Arturo M., Conlon, Kevin C., Brennan, Murray F., Warshaw, Andrew L., Adrian, Thomas E., Herrnanek, P., Wittekind, Ch., Altendorf-Hofmann, A., Reber, Howard A., Korc, Murray, Vezeridis, Michael P., Bold, Richard J., Evers, B. Mark, Sperling, Howard E., Gomez, Guillermo, Ishizuka, Jin, Townsend, Courtney M., Thompson, James C., Kalthoff, H., Röder, C., Henne-Bruns, D., Kremer, B., Schmiegel, W., Smith, Jill Palmer, Zagon, Ian S., Schally, A. V., Szepeshazi, K., Qin, Y., Halmos, G., Ertl, T., Groot, K., Cai, R. -Z., Liebow, C., Poston, G. J., Lemoine, Nick, Beauchamp, Dan, Warshaw, Andrew L., Kim, Young S., Ho, Jenny J. L., Hollingsworth, Michael A., Juhl, Hartmut, Schott, Astrid, Krüger, Uwe, Henne-Bruns, Doris, Kremer, Bernd, Kalthoff, Holger, Lightdale, Charles J., Korc, Murray, Liebow, Charles, Adrian, Thomas E., Permert, Johan, Westermark, Gunilla T., Lehman, Glen A., Schally, A. V., Nagy, A., Cai, R. -Z., Reile, H., Radulovic, S., Qin, Y., Szepeshazi, K., Halmos, G., Comaru-Schally, Ana Maria, Sorenson, G. D., Pribish, D. M., Valone, F. H., Memoli, V. A., Bzik, D. J., Yao, S.-L, Scarpelli, Dante G., Mangold, K. A., Chang, K-W, Laconi, S., Hubchak, S., Szepeshazi, Karoly, Schally, Andrew V., Halmos, G., Longnecker, Daniel S., Pour, Parviz M., Frazier, Marsha L., Fernandez, Ester, de Llorens, Rafael, Löhr, Matthias, Trautmann, Birgit, Heller, Thomas, Peters, Stefanie, Maier, Anja, Schutt, Hans J., Zauner, Ira, Liebe, Stefan, Tsuei, B. J., Povoski, S. P., Zhou, W., Bell, R. H., Dobelbower, Ralph R., Casper, Ephraim S., Smith, Jill P., Liu, Guozhen, Stock, Elizabeth, Orenberg, Elaine K., Yu, Ning Y., Brown, Dennis M., Tempero, Margaret, Colcher, David, Hermanek, P., Gall, F. P., Wittekind, Ch., Altendorf-Hofmann, A., Charks Liebow, Bell, Richard H., Frazier, Marsha L., Hollingsworth, Michael A., Tempero, Margaret, and Comaru-Schally, Ana Maria

Published
1994
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