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101. 444 Variation between experienced surgeons in oncological and functional outcome after prostatectomy. A comparison between open and robotic surgeons in the Swedish LAPPRO study

Author

Gunnar Steineck, Johan Stranne, U. Wilderäng, Stefan Carlsson, E. Haglind, Anders Bjartell, Andrew J. Vickers, Peter Wiklund, M. Nyberg, and Jonas Hugosson

Subjects
medicine.medical_specialty, Variation (linguistics), Prostatectomy, business.industry, Urology, medicine.medical_treatment, medicine, business, Outcome (game theory), Surgery
Published
2016

102. Vasodilator interactions in skeletal muscle blood flow regulation

Author

Y, Hellsten, M, Nyberg, L G, Jensen, and S P, Mortensen

Subjects
Adenosine, Hyperemia, Nitric Oxide, Epoprostenol, Muscle, Smooth, Vascular, Vasodilation, Biological Factors, Adenosine Triphosphate, Oxygen Consumption, Regional Blood Flow, Cyclic AMP, Animals, Homeostasis, Humans, Symposium Section Reviews: Blood Flow Regulation: From Rest to Maximal Exercise, Endothelium, Vascular, Muscle, Skeletal, Cyclic GMP, Exercise, Muscle Contraction, Signal Transduction
Abstract

During exercise, oxygen delivery to skeletal muscle is elevated to meet the increased oxygen demand. The increase in blood flow to skeletal muscle is achieved by vasodilators formed locally in the muscle tissue, either on the intraluminal or on the extraluminal side of the blood vessels. A number of vasodilators have been shown to bring about this increase in blood flow and, importantly, interactions between these compounds seem to be essential for the precise regulation of blood flow. Two compounds stand out as central in these vasodilator interactions: nitric oxide (NO) and prostacyclin. These two vasodilators are both stimulated by several compounds, e.g. adenosine, ATP, acetylcholine and bradykinin, and are affected by mechanically induced signals, such as shear stress. NO and prostacyclin have also been shown to interact in a redundant manner where one system can take over when formation of the other is compromised. Although numerous studies have examined the role of single and multiple pharmacological inhibition of different vasodilator systems, and important vasodilators and interactions have been identified, a large part of the exercise hyperaemic response remains unexplained. It is plausible that this remaining hyperaemia may be explained by cAMP- and cGMP-independent smooth muscle relaxation, such as effects of endothelial derived hyperpolarization factors (EDHFs) or through metabolic modulation of sympathetic effects. The nature and role of EDHF as well as potential novel mechanisms in muscle blood flow regulation remain to be further explored to fully elucidate the regulation of exercise hyperaemia.

Published
2012

103. Influence of nitrate supplementation on VO₂ kinetics and endurance of elite cyclists

Author

P M, Christensen, M, Nyberg, and J, Bangsbo

Subjects
Adult, Male, Kinetics, Nitrates, Oxygen Consumption, Athletes, Dietary Supplements, Physical Endurance, Humans, Energy Intake, Bicycling
Abstract

The present study examined if an elevated nitrate intake would improve VO(2) kinetics, endurance, and repeated sprint capacity in elite endurance athletes. Ten highly trained cyclists (72 ± 4 mL O(2) /kg/min, mean ± standard deviation) underwent testing for VO(2) kinetics (3 × 6 min at 298 ± 28 W), endurance (120 min preload followed by a 400-kcal time trial), and repeated sprint capacity (6 × 20 s sprints, recovery 100 s) during two 6-day periods in randomized order with a daily ingestion of either 0.5 L beetroot (BR) juice to increase nitrate levels or a 0.5 L placebo (PLA) drink with blackcurrant juice. Plasma NOx (nitrate + nitrite) levels were higher (P0.01) in BR (147 ± 102 and 159 ± 103 μM after 4 and 6 days of beverage intake, respectively) compared with PLA (41 ± 10 and 40 ± 7 μM). VO(2) kinetics and exercise economy were the same in BR and PLA. Time-trial performance was similar with an average completion time of 18:20 and 18:37 min:s in BR and PLA, respectively, with average power outputs of 290 ± 43 W in BR and 285 ± 44 W in PLA. Peak and mean power during repeated sprinting were similar in BR and PLA. In contrast to observations in moderately trained subjects intake of BR juice had no effect on VO(2) kinetics and performance in elite cyclists.

Published
2012

104. Contribution of intravascular versus interstitial purines and nitric oxide in the regulation of exercise hyperaemia in humans

Author

Y, Hellsten, M, Nyberg, and S P, Mortensen

Subjects
Adenosine, Adenosine Triphosphate, Hypertension, Humans, Hyperemia, Symposium Section Reviews: Red Blood Cell Mechanisms of Tissue Blood Flow Control, Muscle, Skeletal, Nitric Oxide, Exercise
Abstract

The regulation of blood flow to skeletal muscle involves a complex interaction between several locally formed vasodilators that are produced both in the skeletal muscle interstitium and intravascularly. The gas nitric oxide (NO) and the purines ATP and adenosine, are potent vasodilators that are formed by multiple cell types and released into the skeletal muscle interstitium and in plasma in response to muscle contraction. Cellular sources of ATP and NO in plasma are erythrocytes and endothelial cells, whereas interstitial sources are skeletal muscle cells and endothelial cells. Adenosine originates primarily from extracellular degradation of ATP. During exercise the concentrations of ATP and adenosine increase markedly in the interstitium with smaller increases occurring in plasma, and thus the interstitial concentration during exercise is severalfold higher than in plasma. The concentration of NO metabolites (NOx) in interstitium and plasma does not change during exercise and is similar in the two compartments. Adenosine and NO have been shown to contribute to exercise hyperaemia whereas the role of ATP remains unclear due to lack of specific purinergic receptor blockers. The relative role of intravascular versus interstitial vasodilators is not known but evidence suggests that both compartments are important. In cardiovascular disease, a reduced capacity to form adenosine in the muscle interstitium may be a contributing factor in increased peripheral vascular resistance.

Published
2012

105. Trauma patient satisfaction with physician assistants: testing a structural equation model

Author

Robin E. Crowe, Charles Burdsal, Gina M. Berg, and Sue M. Nyberg

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Cross-sectional study, MEDLINE, Interpersonal communication, Structural equation modeling, Nurse Assisting, Patient satisfaction, Nursing, Trauma Centers, Surveys and Questionnaires, medicine, Humans, Physician assistants, Aged, Quality of Health Care, business.industry, Professional-Patient Relations, Middle Aged, Test (assessment), Cross-Sectional Studies, Physician Assistants, Patient Satisfaction, Family medicine, Workforce, Female, business
Abstract

Physician assistants (PAs) are increasingly utilized in the health care workforce and should be aware of how their interpersonal and technical skills are perceived by patients. The purpose of this study was to test associations among Perceived Interpersonal Care, Perceived Technical Care, and Global Satisfaction.This cross-sectional telephone survey of recently discharged trauma patients tested a structural equation model which hypothesized that interpersonal satisfaction ratings predicted technical care and global satisfaction ratings.A total of 251 completed surveys were analyzed. Results indicated a relationship among interpersonal care, technical care, and global satisfaction. Satisfaction with interpersonal care predicted satisfaction with technical care.In this study of how satisfied recently discharged trauma patients are with care by physician assistants, perceptions of technical care were associated with perceptions of interpersonal care, or how the patient was treated as a person. Since physician assistants have direct patient contact, this association demonstrates the strength of the PA-patient relationship as an asset to the health care organization.

Published
2012

106. Randomized Multicenter Clinical Trial of Myofascial Physical Therapy in Women with Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) and Pelvic Floor Tenderness

Author

Robert D. Mayer, Kathleen J. Propert, W. Featherstone, Leroy M. Nyberg, G.E. Tata, H. Sheth, Christopher K. Payne, Rhonda Kotarinos, Philip M. Hanno, David Burks, Andrea Sanfield, K. Huestis, J.C. Nickel, A. Anaeme, Liyi Cen, Rick Halle-Podell, Emily S. Lukacz, Kenneth M. Peters, J. Chu, Lisa Odabachian, J.R. Landis, John W. Kusek, Karl J. Kreder, M. Mason-Cover, N. Dugan, Toby C. Chai, K. Bewyer, C. Furey, Harris E. Foster, L. Fraser, Carole Fortman, Claire C. Yang, Mary P. FitzGerald, K. Newton, and Todd M. Allen

Subjects
Adult, medicine.medical_specialty, Adolescent, Urology, Cystitis, Interstitial, Physical examination, Pelvic Pain, Article, law.invention, Young Adult, Randomized controlled trial, law, Medicine, Humans, Single-Blind Method, Young adult, Adverse effect, Aged, Massage, Pelvic floor, medicine.diagnostic_test, business.industry, Pelvic pain, Interstitial cystitis, Pelvic Floor, Middle Aged, medicine.disease, Clinical trial, medicine.anatomical_structure, Physical therapy, Female, medicine.symptom, business
Abstract

We determined the efficacy and safety of pelvic floor myofascial physical therapy compared to global therapeutic massage in women with newly symptomatic interstitial cystitis/painful bladder syndrome.A randomized controlled trial of 10 scheduled treatments of myofascial physical therapy vs global therapeutic massage was performed at 11 clinical centers in North America. We recruited women with interstitial cystitis/painful bladder syndrome with demonstrable pelvic floor tenderness on physical examination and a limitation of no more than 3 years' symptom duration. The primary outcome was the proportion of responders defined as moderately improved or markedly improved in overall symptoms compared to baseline on a 7-point global response assessment scale. Secondary outcomes included ratings for pain, urgency and frequency, the O'Leary-Sant IC Symptom and Problem Index, and reports of adverse events. We compared response rates between treatment arms using the exact conditional version of the Mantel-Haenszel test to control for clustering by clinical center. For secondary efficacy outcomes cross-sectional descriptive statistics and changes from baseline were calculated.A total of 81 women randomized to the 2 treatment groups had similar symptoms at baseline. The global response assessment response rate was 26% in the global therapeutic massage group and 59% in the myofascial physical therapy group (p=0.0012). Pain, urgency and frequency ratings, and O'Leary-Sant IC Symptom and Problem Index decreased in both groups during followup, and were not significantly different between the groups. Pain was the most common adverse event, occurring at similar rates in both groups. No serious adverse events were reported.A significantly higher proportion of women with interstitial cystitis/painful bladder syndrome responded to treatment with myofascial physical therapy than to global therapeutic massage. Myofascial physical therapy may be a beneficial therapy in women with this syndrome.

Published
2012

107. A search for heavy leptons at HERA

Author

Peter Robmann, S. Aid, P. E. Reimer, J. Duboc, B. Stella, G. Müller, E. M. Hanlon, Carl R. Brune, M. Barth, L. R. West, V. Korbel, K. Rüter, C. Niebuhr, R. D. Appuhn, H. Krehbiel, A. Gellrich, F. Lamarche, G. G. Winter, B. Gonzalez-Pineiro, Hermann Kolanoski, P. Steffen, D. Clarke, John A Coughlan, Horst Oberlack, K. Rosenbauer, M. Vecko, P. R. Newman, J. Riedlberger, D. Mercer, G. Buschhorn, S. M. Robertson, R. L. Lander, S. Levonian, S. Masson, M. Colombo, D. Goldner, Y. Soloviev, Mikhail Danilov, F. Charles, M. F. Hess, G. Villet, Pierre Marage, H. U. Martyn, Matthias Klein, G. Lindström, K. Stephens, E. Peppel, R. Roosen, C. Gruber, H. P. Wellisch, Max Weber, J. Turnau, T. Jansen, M. Steenbock, Murrough Landon, A. E. Wright, J. Martyniak, G. Thompson, E. Malinovski, M. Kuhlen, A. Courau, B. Andrieu, T. Carli, K. Flamm, Christophe Royon, R. Nisius, Benno List, A. Buniatian, K. C. Hoeger, C. A. Meyer, G. Grindhammer, G. Rädel, D. Lüke, E. Wünsch, B. Fominykh, P. I. P. Kalmus, M. Hampel, B. Kuznik, R. Kaschowitz, W. Hildesheim, Roland Horisberger, A. Valkárová, V. Riech, I. Sheviakov, D. Wegener, W.J. Haynes, Ph. Huet, S. Riess, A. Gruber, I. W. Walker, A. Braemer, K. Rybicki, H. Itterbeck, P. Van Mechelen, M. Hapke, D. Düllmann, H. Henschel, D. Kant, Ch. Pichler, P. Hill, J. Bán, H. J. Behrend, J.C. Bizot, Emmanuelle Perez, Christoph Grab, Kerstin Borras, A. Semenov, M. Goldberg, Peter Schacht, G. C. Lopez, O. Dünger, M. Korn, Winston Ko, Dave Sankey, G. Siegmon, Jean-Arcady Meyer, R. Nahnhauer, E. Barrelet, U. Krüger, F. Botterweck, K. Daum, C. Pascaud, P. Loch, R. Gerhards, G. Weber, U. Straumann, David Cussans, F. Moreau, J. Hladký, J. Martens, Daniel Johnson, Vincent Hedberg, Frank Raupach, G. Knies, Armen Vartapetian, J. D. Dowell, R. J. Ellison, R. Marshall, Guenter Eckerlin, G. Cozzika, Dirk Krücker, L. N. Shtarkov, G. D. Patel, André Schöning, F. Kole, S. Schiek, F. Eisele, A. Jacholkowska, P. Verrecchia, J. R. Smith, S. Dagoret, T. Köhler, M. W. Krasny, F. Linsel, A. Wegener, L. Goerlich, A. Panitch, Martin Erdmann, S. D. Kolya, E. A. De Wolf, Ch. Berger, V. Schröder, R. Herma, Karlheinz Meier, J. Heatherington, J. Haack, Stefan Valkar, U. Obrock, Wolfgang Lange, E. Eisenhandler, Gregorio Bernardi, F. Niebergall, K. H. Hiller, Eckhart Fretwurst, I. O. Skillicorn, H. H. Kaufmann, H. B. Dreis, Eckhard Elsen, F. Brasse, R. C. W. Henderson, D. Newton, J. Gayler, R. Maraček, Anton Babaev, V. Efremenko, J. Ferencei, Steve McMahon, C. Thiebaux, S. Eichenberger, V I. Shekelyan, A. Walther, N. Wulff, J. Tutas, J. D. Burger, R. Prosi, L. Büngener, Hannes Jung, W. von Schlippe, T. Merz, U. Krüner-Marquis, P. Lanius, C. Vallée, E. Sanchez, W. Zimmermann, I. Tichomirov, K. Wacker, R. Steinberg, I. Herynek, J. Baehr, N. Magnussen, S. Mikocki, David Schmidt, J. Strachota, Markus Seidel, V. Tchernyshov, S. Tapprogge, W.D. Dau, N. Sahlmann, E. Evrard, P. Kasselmann, E. Schuhmann, B. Schwab, K. Gabathuler, A. Lebedev, Grzegorz Nowak, S. Egli, J. B. Dainton, C. Jacobsson, P. Biddulph, M. Fleischer, K. Johanssen, M. A. Jabiol, Pavel Murin, H. Grässler, M. Rietz, D. Haidt, H. Hufnagel, J. Feltesse, U. Bassler, M. Ibbotson, G. Bertrand-Coremans, R. Starosta, Daniel Pitzl, J. Kurzhöfer, V. Nagovizin, U. Seehausen, R. Eichler, F. Sefkow, P. Ribarics, G. Heinzelmann, C.D. Hilton, L. Criegee, B. Delcourt, M. Höppner, R. Felst, J.G. Contreras, J. P. Kubenka, U. Kathage, U. Stösslein, H. Meyer, S. Kermiche, Laurent Favart, S. Prell, S. K. Kotelnikov, L. Hajduk, J. Formánek, M. Gebauer, C. Dollfus, J. Garvey, R. Buchholz, C. Leverenz, David Milstead, V. Brisson, G. W. Noyes, A. M. Fomenko, P. A. Smirnov, O. Hamon, H. Küster, H. Shooshtari, F. Rouse, P. Baranov, J. V. Morris, G. Schmidt, Didier Lacour, G. Pope, Peter Schleper, Ulrich Goerlach, Dusan Bruncko, M. Jaffre, J. E. Olsson, Marc Besancon, M. Forbush, A. Schwind, B. Naroska, F. Ferrarotto, A.S. Belousov, Sergey Rusakov, P. Truöl, H. Genzel, W. Bartel, T. Greenshaw, C. Schmidt, J.P. Phillips, J. P. Sutton, P. Di Nezza, Rosario Martín, P. Van Esch, Stephen Maxfield, A. Lindner, J. Janoth, A. Rostovtsev, Claus Kleinwort, J. Stiewe, F. W. Büsser, Volker Blobel, P. Goritchev, C. Keuker, W. Braunschweig, K. Gamerdinger, A. B. Clegg, R. Rylko, Andrew Mehta, N. Gogitidze, R. Sell, D. Neyret, T. Mavroidis, S. Kazarian, U. Siewert, F. Zomer, A. M. Goodall, L. Del Buono, V. Andreev, M. Zimmer, Vincent Boudry, Jean-Francois Laporte, H. Ehrlichmann, Yves Sirois, J. Lipinski, G. Franke, Zhen Zhang, J. Žáček, J. Ebert, J. M. Foster, S. Mani, H. P. Beck, Stephen Burke, A. Usik, M. Savitsky, K. Zuber, J. Cvach, H. Bergstein, Th. Naumann, H. Duhm, E. Gabathuler, E. Deffur, P. Kostka, Ch. Ley, M. David, S. Reinshagen, A. Wagener, H. K. Nguyen, I. V. Gorelov, K. Müller, R. Grässler, Ch. Coutures, W. Struczinski, M. Flieser, J. Stier, M. Arpagaus, Y. Vazdik, M. Nyberg-Werther, T. R. Ebert, A. Fedotov, Günter Flügge, T. P. Yiou, C. Kiesling, A. De Roeck, A. J. Campbell, Richard E. Taylor, T. Ahmed, Th. Wolff, T. Kurča, S. Willard, I. R. Kenyon, H. Spitzer, M. Winde, R. Bernet, P. Uelkes, L. Johnson, H. E. Roloff, Leif J. Jönsson, H. Lohmander, and D. Feeken

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Branching fraction, Astrophysics::High Energy Astrophysical Phenomena, Electron–positron annihilation, High Energy Physics::Phenomenology, HERA, Massless particle, Nuclear physics, Particle decay, W and Z bosons, High Energy Physics::Experiment, Neutrino, Lepton
Abstract

A search for direct production of new leptons in the mass range from 10 GeV up to 225 GeV is presented by the H1 experiment at HERA. The data were obtained during 1993 and correspond to an integrated luminosity of 528 nb −1 . The search includes heavy lepton decays to final states e ( ν ) γ and e ( ν ) W , e ( ν ) Z with the subsequent decay of the W and Z bosons into jets or lepton pairs. No evidence was found for the production of new massive electrons or neutrinos in any of the decay channels. Rejection limits for excited electrons and neutrinos are derived.

Published
1994

108. Density functional approximations for classical fluids with long-range interactions

Author

Jerome K. Percus and A. M. Nyberg

Subjects
Thermal equilibrium, Physics, Statistical and Nonlinear Physics, Classical fluids, Calculation methods, Hybrid functional, symbols.namesake, Range (mathematics), Classical mechanics, Quantum mechanics, symbols, van der Waals force, Local-density approximation, Mathematical Physics
Abstract

Density functional approximations for systems interacting via long-range forces are revisited. The theory is illustrated with examples of one-component plasmas in two and three dimensions.

Published
1994

109. Inclusive charged particle cross sections in photoproduction at HERA

Author

T. Jansen, T. Ahmed, Th. Wolff, I. Tichomirov, G. Rädel, L. Criegee, H. Hufnagel, S. Kermiche, J. Formánek, R. D. Appuhn, M. Hampel, Ph. Huet, C.D. Hilton, M. Gebauer, J. Garvey, Ch. Pichler, A. M. Fomenko, I. R. Kenyon, K. Stephens, E. Peppel, M. Gennis, R. C. W. Henderson, S. Levonian, E. Malinovski, M. Kuhlen, H. Spitzer, P. Baranov, J. Tutas, J. D. Burger, Peter Schleper, G. Grindhammer, C. Bourdarios, R. Prosi, A. Buniatian, Marc Besancon, A.S. Belousov, Sergey Rusakov, P. Truöl, G. Lindström, C. Gruber, M. Nyberg, J. Harjes, S. M. Robertson, Dusan Bruncko, K. Flamm, D. Wegener, W.J. Haynes, A. Mavroidis, P. Goritchev, S. K. Kotelnikov, L. Hajduk, W. Flauger, D. Pitzl, R. Roosen, Mikhail Danilov, D. Lewin, Grzegorz Nowak, J. Martyniak, C. Jacobsson, B. Fominykh, Emmanuel Monnier, Eckhart Fretwurst, Fabian Zomer, B. Naroska, F. Ferrarotto, K. Gamerdinger, T. Köhler, M. W. Krasny, H. Genzel, J. Martens, P. I. P. Kalmus, Michel Devel, J. M. Foster, V. Efremenko, Peter Loch, D. Kant, P. Dingus, W. von Schlippe, K. Johannsen, Kerstin Borras, Didier Lacour, T. Merz, R. J. Ellison, G. Cozzika, J. Hladký, A. Braemer, T. Greenshaw, G. Siegmon, J. Feltesse, J. Ebert, F. Eisele, S. Mikocki, C. A. Meyer, J.P. Phillips, W. Pilgram, Christophe Royon, A. Semenov, K. C. Hoeger, J. Žáček, Steve McMahon, U. Kathage, M. Savitsky, A. Gruber, Peter Schacht, G. C. Lopez, J. Haack, H. Bergstein, Th. Naumann, F. Moreau, J. D. Dowell, A. Jacholkowska, Rosario Martín, J. Ferencei, Leith Godfrey, W. Schmitz, V. Brisson, S. Aid, F. Charles, R. Taylor, P. Van Esch, H. Greif, P. Robmann, P. Fuhrmann, N. Magnussen, M. Goldberg, Max Klein, V. Boudry, H. Duhm, E. Vogel, Gregorio Bernardi, C. Niebuhr, Anton Babaev, M. Rudowicz, J. Marks, S. D. Kolya, S. Mani, L. N. Shtarkov, C. Thiebaux, J. Strachota, Hannes Jung, Mario David, Claus Kleinwort, F. Brasse, J. Turnau, J. Cvach, L. Goerlich, A. Drescher, I. Abt, T. P. Yiou, Stephen Burke, L. R. West, U. Bassler, I.F. Fensome, Winston Ko, E. Gabathuler, E. Deffur, D. Feeken, D. Goldner, P. Kostka, Leif J. Jönsson, Guenter Eckerlin, R. Vick, R. Nisius, André Schöning, C. Vallée, M. Steenbock, A. Lindner, S. J. Maxfiedl, Y. Soloviev, I. Sheviakov, A. Usik, E. Barrelet, A. M. Goodall, Volker Blobel, Ch. Berger, R. Eichler, C. Keuker, H. Lohmander, P. A. Smirnov, U. Krüger, E. Evrard, W. Hildesheim, P. R. Newman, B. Andrieu, A. Gellrich, V. Riech, Karlheinz Meier, P. Ribarics, V. Andreev, G. Villet, R. Felst, Pierre Marage, L. Büngener, D. Mercer, F. Lamarche, B. Schwab, M. Eberle, W. Lange, S. Willard, Roland Bernet, J. R. Smith, J. E. Olsson, W. Bartel, I. W. Walker, R. Herma, Hermann Kolanoski, S. Dagoret, Pavel Murin, H. Grässler, J. Moreels, K. Rybicki, D. Clarke, A. Courau, M. Ibbotson, M. Vecko, T. R. Ebert, John A Coughlan, M. Winde, A. Leuschner, Christoph Grab, L. Johnson, H. Ehrlichmann, E. Eisenhandler, M. Hapke, S. Masson, R. Langkau, Horst Oberlack, F. W. Büsser, W. Braunschweig, A. Fedotov, Günter Flügge, B. Delcourt, R. Sell, S. Kazarian, U. Siewert, A. B. Clegg, Andrew Mehta, N. Gogitidze, Laurent Favart, C. Dollfus, S. Reinshagen, U. Stösslein, V I. Shekelyan, R. Haydar, F. Kole, N. Sahlmann, C. Kiesling, Armen Vartapetian, E. Schuhmann, A. De Roeck, P. C. Bosetti, C. Leverenz, K. Wacker, R. Steinberg, B. Stella, A. Rostovtsev, M. Arpagaus, P. Biddulph, R. Ebbinghaus, M. Zimmer, J. Lipinski, Jean-Francois Laporte, Ulrich Goerlach, L. Urban, G. Franke, M. A. Jabiol, B. Kuznik, T. Kurča, R. L. Lander, M. Ruffer, K. Rosenbauer, M. Flieser, S. Orenstein, G. Bertrand-Coremans, H. Bärwolff, S. Eichenberger, Frank Raupach, J. Stier, R. Kaschowitz, Y. Vazdik, Y. Sirois, Jean-Arcady Meyer, M. Jaffré, H. Meyer, N. Wulff, A. Valkárová, P. Kasselmann, G. Thompson, A. Wegner, M. Colombo, M. Fleischer, S. Riess, H. Ziaeepour, W.D. Dau, J. B. Dainton, J. Kurzhöfer, V. Nagovizin, D. Düllmann, Hans Peter Beck, R. Gerhards, P. Hill, A. W. E. Dann, J. P. Kubenka, H. Henschel, J. Bán, Ch. Ley, U. Seehausen, H. J. Behrend, J.C. Bizot, D. Lüers, Murrough Landon, N. Huot, G. W. Noyes, P. Verrecchia, A. E. Wright, K. Müller, P. E. Reimer, H. Shooshtari, V. Schröder, J. Riedlberger, H. H. Kaufmann, Eckhard Elsen, D. Neyret, Nicolas Ellis, Alan Campbell, E. M. Hanlon, H. Itterbeck, S. Peters, H. K. Nguyen, I. V. Gorelov, O. Hamon, G. G. Winter, R. Grässler, Ch. Coutures, W. Struczinski, Vincent Hedberg, G. Knies, P. Steffen, I. O. Skillicorn, H. B. Dreis, H. P. Wellisch, T. Carli, V. Korbel, F. Linsel, J. Heatherington, D. Newton, P. Lanius, V. Tchernyshov, M. Korn, G. Weber, U. Straumann, H. U. Martyn, F. Ould-Saada, M. Höppner, S. Prell, S. A. Murray, J. Chyla, Martin Erdmann, U. Obrock, F. Niebergall, J. Duboc, C. Schmidt, J. P. Sutton, P. Di Nezza, U. Braun, K. Rauschnabel, E. Binder, H.T. Phillips, M. Schulz, J. Gayler, E. Sanchez, L. Del Buono, O. Dünger, R. Marshall, Dirk Krücker, H. Krehbiel, G. Buschhorn, I. Herynek, L.A. Womersley, A. Walther, W. Zimmermann, J. V. Morris, M. Forbush, A. Schwind, C. Pascaud, A. Lebedev, S. Egli, M. Rietz, D. Haidt, G. Heinzelmann, S. Valkar, H. Küster, D. Lüke, C. Zeitnitz, Dave Sankey, G. D. Patel, W. Scobel, D.P. Johnson, and David Schmidt

Subjects
Quantum chromodynamics, Physics, Nuclear and High Energy Physics, Wire chamber, Particle physics, Elementary particle, HERA, Charged particle, Nuclear physics, Particle mass, Pseudorapidity, Transverse momentum, High Energy Physics::Experiment, Nuclear Experiment
Abstract

Cross sections are presented for the inclusive production of charged particles measured in electron-proton collisions at low Q 2 with the H1 detector at HERA. The transverse momentum distribution extends up to 8 GeV/ c . Its shape is found to be harder than that observed in p p collisions at comparable centre-of-mass energies √S γp ≈ √S p p ≈ 200 GeV , and also harder than in γp collisions at lower energies √ S γp ≈ 18 GeV. Results from quantum chromodynamics (QCD) calculations agree with the measured transverse momentum and pseudorapidity cross sections.

Published
1994

110. First measurement of the charged current cross section at HERA

Author

T. Ahmed, V. Andreev, B. Andrieu, R.-D. Appuhn, M. Arpagaus, A. Babaev, J. Bán, P. Baranov, E. Barrelet, W. Bartel, M. Barth, U. Bassler, H.P. Beck, H.-J. Behrend, A. Belousov, Ch. Berger, H. Bergstein, G. Bernardi, R. Bernet, G. Bertrand-Coremans, M. Besançon, P. Biddulph, J.C. Bizot, V. Blobel, K. Borras, V. Boudry, A. Braemer, F. Brasse, W. Braunschweig, V. Brisson, D. Bruncko, C. Brune, L. Büngener, J. Bürger, F.W. Büsser, A. Buniatian, S. Burke, G. Buschhorn, A.J. Campbell, T. Carli, F. Charles, D. Clarke, A.B. Clegg, M. Colombo, J.A. Coughlan, A. Courau, Ch. Coutures, G. Cozzika, L. Criegee, D.G. Cussans, J. Cvach, S. Dagoret, J.B. Dainton, M. Danilov, A.W.E. Dann, W.D. Dau, K. Daum, M. David, E. Deffur, B. Delcourt, L. Del Buono, A. De Roeck, E. De Wolf, C. Dollfus, J.D. Dowell, H.B. Dreis, J. Duboc, D. Düllmann, O. Dünger, H. Duhm, J. Ebert, T.R. Ebert, G. Eckerlin, V. Efremenko, S. Egli, H. Ehrlichmann, S. Eichenberger, R. Eichler, F. Eisele, E. Eisenhandler, R.J. Ellison, E. Elsen, M. Erdmann, E. Evrard, L. Favart, A. Fedotov, D. Feeken, R. Felst, J. Feltesse, J. Ferencei, F. Ferrarotto, K. Flamm, W. Flauger, M. Fleischer, M. Flieser, G. Flügge, A. Fomenko, B. Fominykh, M. Forbush, J. Formánek, J.M. Foster, G. Franke, E. Fretwurst, E. Gabathuler, K. Gamerdinger, J. Garvey, J. Gayler, M. Gebauer, A. Gellrich, H. Genzel, R. Gerhards, U. Goerlach, L. Goerlich, N. Gogitidze, M. Goldberg, D. Goldner, A.M. Goodall, I. Gorelov, P. Goritchev, C. Grab, H. Grässler, R. Grässler, T. Greenshaw, G. Grindhammer, C. Gruber, J. Haack, D. Haidt, L. Hajduk, O. Hamon, M. Hampel, E.M. Hanlon, M. Hapke, W.J. Haynes, J. Heatherington, V. Hedberg, G. Heinzelmann, R.C.W. Henderson, H. Henschel, R. Herma, I. Herynek, W. Hildesheim, P. Hill, C.D. Hilton, J. Hladký, K.C. Hoeger, M. Höppner, Ph. Huet, H. Hufnagel, M. Ibbotson, H. Itterbeck, M.-A. Jabiol, A. Jacholkowska, C. Jacobsson, M. Jaffre, J. Janoth, T. Jansen, L. Jönsson, K. Johannsen, D.P. Johnson, L. Johnson, H. Jung, P.I.P. Kalmus, D. Kant, S. Kazarian, R. Kaschowitz, P. Kasselmann, U. Kathage, H.H. Kaufmann, I.R. Kenyon, S. Kermiche, C. Keuker, C. Kiesling, M. Klein, C. Kleinwort, G. Knies, W. Ko, T. Köhler, H. Kolanoski, F. Kole, S.D. Kolya, V. Korbel, M. Korn, P. Kostka, S.K. Kotelnikov, M.W. Krasny, H. Krehbiel, D. Krücker, U. Krüger, M. Krüner-Marquis, J.P. Kubenka, H. Küster, M. Kuhlen, T. Kurča, J. Kurzhöfer, B. Kuznik, D. Lacour, F. Lamarche, R. Lander, M.P.J. Landon, W. Lange, P. Lanius, J.F. Laporte, A. Lebedev, C. Leverenz, S. Levonian, Ch. Ley, A. Lindner, G. Lindström, F. Linsel, J. Lipinski, P. Loch, H. Lohmander, G.C. Lopez, D. Lüers, D. Lüke, N. Magnussen, E. Malinovski, S. Mani, P. Marage, R. Marshall, J. Martens, R. Martin, H.-U. Martyn, J. Martyniak, S. Masson, A. Mavroidis, S.J. Maxfield, S.J. McMahon, A. Mehta, K. Meier, D. Mercer, T. Merz, C.A. Meyer, H. Meyer, J. Meyer, S. Mikocki, V. Milone, D. Milstead, F. Moreau, J.V. Morris, G. Müller, P. Murín, V. Nagovizin, B. Naroska, Th. Naumann, G. Nawrath, P.R. Newman, D. Newton, D. Neyret, H.K. Nguyen, F. Niebergall, C. Niebuhr, R. Nisius, G. Nowak, G.W. Noyes, M. Nyberg-Werther, H. Oberlack, U. Obrock, J.E. Olsson, A. Panitch, C. Pascaud, G.D. Patel, E. Peppel, E. Perez, J.P. Phillips, Ch. Pichler, D. Pitzl, G. Pope, S. Prell, R. Prosi, G. Rädel, F. Raupach, P. Reimer, S. Reinshagen, P. Ribarics, V. Riech, J. Riedlberger, S. Riess, M. Rietz, S.M. Robertson, P. Robmann, R. Roosen, K. Rosenbauer, A. Rostovtsev, C. Royon, K. Rüter, M. Ruffer, S. Rusakov, K. Rybicki, N. Sahlmann, E. Sanchez, D.P.C. Sankey, M. Savitsky, P. Schacht, P. Schleper, W. von Schlippe, C. Schmidt, D. Schmidt, A. Schöning, V. Schröder, M. Schulz, B. Schwab, A. Schwind, U. Seehausen, F. Sefkow, R. Sell, A. Semenov, V. Shekelyan, I. Sheviakov, H. Shooshtari, L.N. Shtarkov, G. Siegmon, U. Siewert, Y. Sirois, I.O. Skillicorn, P. Smirnov, J.R. Smith, Y. Soloviev, H. Spitzer, P. Staroba, M. Steenbock, P. Steffen, R. Steinberg, B. Stella, K. Stephens, J. Stier, J. Stiewe, U. Stösslein, J. Strachota, U. Straumann, W. Struczinski, J.P. Sutton, S. Tapprogge, R.E. Taylor, V. Tchernyshov, C. Thiebaux, G. Thompson, I. Tichomirov, P. Truöl, J. Turnau, J. Tutas, A. Usik, S. Valkar, A. Valkarova, C. Vallée, P. Van Esch, P. Van Mechelen, A. Vartapetian, Y. Vazdik, M. Vecko, P. Verrecchia, G. Villet, K. Wacker, A. Wagener, I.W. Walker, A. Walther, G. Weber, M. Weber, D. Wegener, A. Wegner, H.P. Wellisch, L.R. West, S. Willard, M. Winde, G.-G. Winter, Th. Wolff, A.E. Wright, E. Wünsch, N. Wulff, T.P. Yiou, J. Žáček, Z. Zhang, M. Zimmer, W. Zimmermann, F. Zomer, and K. Zuber

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Nuclear Theory, High Energy Physics::Phenomenology, Hadron, Propagator, Elementary particle, HERA, Nuclear physics, Cross section (physics), Transverse plane, High Energy Physics::Experiment, Nuclear Experiment, Charged current
Abstract

The cross section of the charged current process e − p → v e + hadrons is measured at HERA for transverse momenta of the hadron system larger than 25 GeV. The size of the cross section exhibits the W propagator.

Published
1994

111. The H1 forward muon spectrometer

Author

C.D. Hilton, P. Sutton, M. Ibbotson, C. Jacobsson, P. Biddulph, H. I. Cronström, M. Nyberg, P. Finnegan, J. M. Foster, I. R. Kenyon, Vincent Hedberg, Robert Thompson, K. Stephens, S. Gilbert, Andrew Mehta, Leif J. Jönsson, H. Lohmander, and H. Phillips

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Toroid, Muon, Proton, Physics::Instrumentation and Detectors, Detector, HERA, Electron, law.invention, Nuclear physics, law, Magnet, Physics::Accelerator Physics, High Energy Physics::Experiment, Nuclear Experiment, Collider, Instrumentation
Abstract

The H1 detector started taking data at the electron-proton collider HERA in the beginning of 1992. In HERA 30 GeV electrons collide with 820 GeV protons giving a strong boost of the centre-of-mass system in the direction of the proton, also called the forward region. For the detection of high momentum muons in this region a muon spectrometer has been constructed, consisting of six drift chamber planes, three either side of a toroidal magnet. A first brief description of the system and its main parameters as well as the principles for track reconstruction and T 0 determination is given.

Published
1994

112. Scaling violations of the proton structure function F2 at small x

Author

F. Kole, B. Schwab, Petr Zavada, Pavel Murin, H. Grässler, M. Ibbotson, M. Schulz, D. Lüers, F. Charles, R. Taylor, N. Magnussen, Steve McMahon, Armen Vartapetian, Th. Wolff, Pavel Staroba, P. Verrecchia, H. Spitzer, Richard Nisius, Michel Devel, M. Colombo, E. Evrard, W.D. Dau, J. B. Dainton, Claire Bourdarios, Laurent Favart, C. Dollfus, J. Turnau, M. Steenbock, B. Andrieu, N. Sahlmann, V. Korbel, J. E. Olsson, W. Bartel, Stephen Maxfield, Kerstin Borras, C. Pascaud, V. Schröder, W. von Schlippe, H. H. Kaufmann, Eckhard Elsen, R. Marshall, Dirk Krücker, I. Tichomirov, Murrough Landon, A. E. Wright, G. Lindström, B. Delcourt, G. Bertrand-Coremans, J. Feltesse, Ulrich Goerlach, R. Kaschowitz, R. Ebbinghaus, A. B. Clegg, N. Gogitidze, F. W. Büsser, W. Braunschweig, K. C. Hoeger, Leif J. Jönsson, H. Hufnagel, Alexandre Lebedev, H. Lohmander, L. Criegee, A. Semenov, J. Riedlberger, M. Nyberg, S. Egli, M. Rietz, T. Merz, S. Kasarian, U. Stösslein, C. Leverenz, J. Žáček, Max Klein, L.A. Womersley, J. Formánek, M. A. Jabiol, V. Riech, R. Sell, A. Valkárová, S. Orenstein, J. Harjes, S. M. Robertson, S. Riess, G. Heinzelmann, Mario David, S. Kermiche, E. Barrelet, Tancredi Carli, I. R. Kenyon, S. Reinshagen, A. Walther, C.D. Hilton, Fabian Zomer, M. Hapke, F. Linsel, P. A. Smirnov, A. Lindner, L. N. Shtarkov, U. Bassler, Ch. Berger, Karlheinz Meier, J. Ebert, U. Siewert, F. Brasse, W. Zimmermann, Hans Peter Beck, H. Itterbeck, S. Peters, M. Zimmer, E. Malinovski, M. Kuhlen, Vincent Boudry, A. Buniatian, Mikhail Danilov, J. Heatherington, R. C. W. Henderson, I. F. Fensome, Volker Blobel, K. Stephens, E. Peppel, D. Newton, D. Lewin, L. Büngener, V. Milone, S. Eichenberger, G. Cozzika, D. Wegener, W.J. Haynes, Jean-Francois Laporte, Jean-Arcady Meyer, R. Eichler, C. Keuker, R. Roosen, H. Shooshtari, G. Grindhammer, J. Martyniak, R. Gerhards, A. Drescher, O. Hamon, M. Fleischer, Ch. Ley, Dave Sankey, D. Handschuh, I. Herynek, P. Lanius, Emmanuel Monnier, S. A. Murray, S. Levonian, H. Krehbiel, T. Köhler, M. W. Krasny, P. E. Reimer, B. Fominykh, E. M. Hanlon, V. Tchernyshov, Stefan Valkar, M. Arpagaus, J. Duboc, B. Stella, H. T. Phillips, H. Greif, P. Hill, J. Bán, P. Ribarics, C. Niebuhr, R. Felst, G. D. Patel, H. Meyer, Paul Newman, K. Flamm, A. Mavroidis, V. Efremenko, Hannes Jung, G. Buschhorn, Daniel Pitzl, G. G. Winter, S. Mani, R. M. Martin, J. Tutas, J. D. Burger, M. Rudowicz, M. Eberle, L. Smolik, U. Seehausen, Grzegorz Nowak, Eckhart Fretwurst, M. Korn, P. I. P. Kalmus, David Schmidt, Vincent Hedberg, G. Knies, S. Mikocki, P. Steffen, C. Vallée, P. Biddulph, I. Abt, Stephen Burke, Martin Erdmann, R. Prosi, U. Obrock, F. Niebergall, Nicolas Ellis, G. Weber, U. Straumann, J. V. Morris, H. P. Wellisch, A. Wegner, T. Ahmed, K. Johannsen, J. R. Smith, R. Herma, Christophe Royon, A. Usik, R. D. Appuhn, E. Eisenhandler, Y. Soloviev, T. Kurca, S. K. Kotelnikov, L. Hajduk, M. Jaffré, H. K. Nguyen, I. V. Gorelov, K. Müller, P. Dingus, A. M. Goodall, M. Forbush, P. Baranov, H. Ziaeepour, R. Grässler, Ch. Coutures, W. Struczinski, Peter Schacht, G. C. Lopez, C. A. Meyer, J. Kurzhöfer, A. Schwind, V. Nagovizin, M. Vecko, Peter Schleper, J. Haack, A. W. E. Dann, C. Zeitnitz, Rudolf Langkau, H. Küster, W. Schmitz, A. Gellrich, V. Andreev, M. Rüffer, J. M. Foster, R. J. Ellison, F. Lamarche, M. Savitsky, I. O. Skillicorn, H. B. Dreis, I. W. Walker, K. Rybicki, J. P. Kubenka, Marc Besancon, P. Fuhrmann, A.S. Belousov, D. Düllmann, H. U. Martyn, Sergey Rusakov, P. Truöl, Peter Loch, Winston Ko, Didier Lacour, Guenter Eckerlin, Daniel Johnson, E. Vogel, G. W. Noyes, M. Gennis, H. Henschel, H. J. Behrend, J.C. Bizot, M. Goldberg, Hermann Kolanoski, D. Clarke, John A Coughlan, W. Pilgram, J. Cvach, Gregorio Bernardi, Anton Babaev, C. Thiebaux, Horst Oberlack, A. Leuschner, Christoph Grab, L. Goerlich, R. Vick, André Schöning, I. Sheviakov, G. Villet, Pierre Marage, Yves Sirois, Frank Raupach, J. Strachota, U. Krüger, A. Courau, Roland Bernet, J. Lipinski, K. Gamerdinger, S. Dagoret, J. Garvey, J. Hladký, F. Eisele, G. Franke, V I. Shekelyan, A. M. Fomenko, J. D. Dowell, R. Haydar, P. C. Bosetti, G. Siegmon, Wolfgang Scobel, Ankita Mehta, N. Wulff, K. Wacker, R. Steinberg, E. J. Sanchez, N. Huot, P. Goritchev, Dusan Bruncko, P. Kasselmann, B. Naroska, F. Ferrarotto, H. Genzel, T. Greenshaw, D. Neyret, J.P. Phillips, D. Feeken, W. Hildesheim, R. L. Lander, J. Ferencei, H. Bärwolff, P. Van Esch, J. Marks, A. Rostovtsev, Claus Kleinwort, F. Moreau, S. Willard, A. Jacholkowska, M. Winde, S. D. Kolya, L. Johnson, T. Jansen, G. Rädel, B. Kuznik, Ph. Huet, Ch. Pichler, C. Gruber, W. Flauger, K. Rauschnabel, Wolfgang Lange, E. Binder, J. Gayler, G. Thompson, S. Prell, C. Jacobsson, U. Kathage, C. Schmidt, J. P. Sutton, U. Braun, H. Bergstein, Peter Robmann, Th. Naumann, L. Del Buono, A. Bischoff, H. Duhm, E. Gabathuler, E. Deffur, O. Dünger, P. Kostka, J. Moreels, T. R. Ebert, A. Fedotov, Günter Flügge, T. P. Yiou, C. Kiesling, A. De Roeck, A. J. Campbell, Farid Ould-Saada, Leith Godfrey, L. Urban, M. Flieser, D. Mercer, J. Stier, Y. Vazdik, L.R. West, S. Masson, J. Martens, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and H1

Subjects
Physics, Nuclear physics, Nuclear and High Energy Physics, Particle physics, Distribution function, Proton, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Range (statistics), Perturbative QCD, HERA, Event (particle physics), Scaling, Gluon
Abstract

An analysis is presented of scaling violations of the proton structure function F 2 ( x , Q 2 ) measured with the H1 detector at HERA in the range of Bjorken x values between x = 3 × 10 −4 and 10 −2 for four-momentum transfers Q > 2 larger than 8.7 GeV 2 . The structure function F 2 ( x , Q 2 ) is observed to rise linearly with ln Q 2 . Under the assumption that the observed scaling violations at small x ⩽ 0.01 are described correctly by perturbative QCD, an estimate is obtained of the gluon distribution function G ( x , Q 0 2 ) at Q 2 2 = 20 GeV 2 .

Published
1994

113. Prevalence of Symptoms of Bladder Pain Syndrome/Interstitial Cystitis Among Adult Females in the United States

Author

Leroy M. Nyberg, J. Quentin Clemens, Michael A. Stoto, Marika J. Suttorp, Marc N. Elliott, Sandra H. Berry, Paul W. Eggers, and Laura M. Bogart

Subjects
Adult, medicine.medical_specialty, SF-36, Adolescent, Cross-sectional study, Urology, Urinary system, Population, Cystitis, Interstitial, Article, Young Adult, Internal medicine, Epidemiology, medicine, Prevalence, Humans, Young adult, education, Aged, Gynecology, education.field_of_study, Urinary bladder, business.industry, Interstitial cystitis, Middle Aged, medicine.disease, United States, medicine.anatomical_structure, Female, business
Abstract

Bladder pain syndrome/interstitial cystitis is a poorly understood condition that can cause serious disability. We provide the first population based symptom prevalence estimate to our knowledge among United States adult females.We developed and validated 2 case definitions to identify bladder pain syndrome/interstitial cystitis symptoms. Beginning in August 2007 we telephoned United States households, seeking adult women with bladder symptoms or a bladder pain syndrome/interstitial cystitis diagnosis. Second stage screening identified those subjects who met case definition criteria. Each completed a 60-minute interview on the severity and impact of bladder symptoms, health care seeking and demographics. Data collection ended in April 2009. Using population and nonresponse weights we calculated prevalence estimates based on definitions spanning a range of sensitivity and specificity. We used United States Census counts to estimate the number of affected women in 2006. The random sample included 146,231 households, of which 131,691 included an adult female. Of these households 32,474 reported an adult female with bladder symptoms or diagnosis, of which 12,752 completed the questionnaire.Based on the high sensitivity definition 6.53% (95% CI 6.28, 6.79) of women met symptom criteria. Based on the high specificity definition 2.70% (95% CI 2.53, 2.86) of women met the criteria. These percentages translated into 3.3 to 7.9 million United States women 18 years old or older with bladder pain syndrome/interstitial cystitis symptoms. Symptom severity and impact were comparable to those of adult women with established diagnoses. However, only 9.7% of the women reported being assigned a bladder pain syndrome/interstitial cystitis diagnosis.Bladder pain syndrome/interstitial cystitis symptoms are widespread among United States women and associated with considerable disability. These results suggest bladder pain syndrome/interstitial cystitis may be underdiagnosed.

Published
2011

116. Measurement of the proton structure function F2 (x, Q2) in the low-x region at HERA

Author

Steve McMahon, C. A. Meyer, G. Siegmon, A. Drescher, P. Fuhrmann, F. Moreau, J. Hladký, J. D. Dowell, A. Jacholkowska, A. Lebedev, S. Egli, G. Villet, L. Goerlich, S. D. Kolya, M. Rietz, D. Haidt, Pierre Marage, G. Heinzelmann, A. Courau, H. Küster, A. Usik, N. Magnussen, R. C. W. Henderson, N. Sahlmann, P. Biddulph, M. Colombo, J. V. Morris, Frank Raupach, R. Ebbinghaus, M. A. Jabiol, A. E. Wright, J. Tutas, J. D. Burger, N. Wulff, R. Prosi, P. Kasselmann, D. P. C. Sankey, U. Bassler, Daniel Pitzl, M. Forbush, V. Milone, A. Schwind, M. Jaffre, J. E. Olsson, W. Bartel, H. Itterbeck, S. Peters, R. Felst, S. K. Kotelnikov, L. Hajduk, M. Eberle, F. W. Büsser, W. Braunschweig, R. Sell, C. Zeitnitz, V. Korbel, K. C. Hoeger, T. Jansen, U. Siewert, M. Zimmer, Vincent Boudry, Jean-Francois Laporte, G. D. Patel, H. Meyer, Peter Loch, W. Scobel, Vincent Hedberg, G. Rädel, G. Knies, B. Kuznik, Ph. Huet, W. Pilgram, D. Lüers, Ch. Pichler, D.P. Johnson, David Schmidt, J. Haack, I. O. Skillicorn, H. B. Dreis, Ch. Ley, Peter Schacht, G. C. Lopez, W. Schmitz, V. Riech, M. Hapke, R. Bernet, Pavel Staroba, Kerstin Borras, E. Vogel, Gregorio Bernardi, Anton Babaev, G. Cozzika, F. Eisele, A. Buniatian, D. Wegener, W. von Schlippe, A. Semenov, T. Merz, J. Turnau, J. Strachota, W.J. Haynes, P. Verrecchia, I.F. Fensome, P. Goritchev, Stefan Valkar, M. Steenbock, A. Lindner, Volker Blobel, C. Keuker, R. Roosen, Emmanuel Monnier, V. Schröder, S. Kasarian, K. Gamerdinger, T. Köhler, D. Neyret, S. Levonian, K. Rauschnabel, Wolfgang Lange, B. Andrieu, Hannes Jung, K. Johannsen, B. Schwab, C. Vallée, E. Malinovski, Pavel Murin, D. Mercer, H. Grässler, J. Riedlberger, H. K. Nguyen, F. Brasse, E. Binder, M. Ibbotson, H. H. Kaufmann, Eckhard Elsen, Leif J. Jönsson, M. Nyberg, J. Harjes, Christophe Royon, P. Baranov, Laurent Favart, C. Dollfus, I. V. Gorelov, K. Müller, J. Gayler, Jean-Arcady Meyer, V. Efremenko, Mario David, F. Linsel, Peter Schleper, Ulrich Goerlach, R. Grässler, Ch. Coutures, W. Struczinski, J. Heatherington, J. M. Foster, R. Kaschowitz, S. M. Robertson, R. Gerhards, P. Závada, E. Evrard, M. Savitsky, E. Sanchez, S. Riess, M. Kuhlen, H. Lohmander, G. Grindhammer, S. Mikocki, K. Flamm, A. Mavroidis, D. Newton, L. N. Shtarkov, Leith Godfrey, Marc Besancon, J. Cvach, F. Zomer, A. M. Goodall, L. Del Buono, Winston Ko, B. Delcourt, A.S. Belousov, Sergey Rusakov, U. Stösslein, P. Lanius, C. Pascaud, I. W. Walker, K. Rybicki, J. Duboc, B. Stella, S. Kermiche, P. I. P. Kalmus, P. Hill, J. Bán, P. Truöl, Mikhail Danilov, Peter Robmann, D. Lewin, H. Greif, L. Criegee, Stephen Maxfield, C. Leverenz, V. Tchernyshov, A. Leuschner, Christoph Grab, O. Hamon, Nicolas Ellis, Guenter Eckerlin, J. Martyniak, E. Barrelet, R. Vick, M. Vecko, A. B. Clegg, Andrew Mehta, T. Ahmed, J. Formánek, A. Bischoff, Th. Wolff, M. Rudowicz, Yves Sirois, H. Shooshtari, I. R. Kenyon, I. Abt, M. Korn, J. Lipinski, R. Nisius, B. Fominykh, G. Franke, J. Žáček, S. Masson, R. Langkau, M. Ruffer, Armen Vartapetian, G. Thompson, S. Orenstein, G. Weber, U. Straumann, H. Spitzer, Ch. Berger, O. Dünger, J. Ebert, R. J. Ellison, L.A. Womersley, R. L. Lander, H. Bärwolff, A. Gellrich, F. Lamarche, S. Mani, R. D. Appuhn, D. Düllmann, J. R. Smith, H. P. Beck, Eckhart Fretwurst, S. Eichenberger, H. Henschel, Stephen Burke, R. Herma, I. Tichomirov, E. Eisenhandler, L. Büngener, J. Martens, H. J. Behrend, J.C. Bizot, M. Goldberg, M. Gennis, M. Fleischer, Hermann Kolanoski, D. Clarke, Michel Devel, John A Coughlan, K. Meier, Horst Oberlack, A. Walther, S. Prell, F. Kole, G. Bertrand-Coremans, G. Lindström, C. Gruber, W. Flauger, L. Smolik, U. Seehausen, H. Hufnagel, W. Zimmermann, I. Herynek, J. Garvey, A. M. Fomenko, A. Wegner, C.D. Hilton, P. Kotska, Grzegorz Nowak, C. Jacobsson, C. Schmidt, J. P. Sutton, U. Braun, N. Huot, H. Ziaeepour, H.T. Phillips, M. Schulz, J. Kurzhöfer, V. Nagovizin, W.D. Dau, A. W. E. Dann, J. B. Dainton, R. Eichler, M. W. Krasny, Claire Bourdarios, R. Marshall, Dirk Krücker, U. Kathage, D. Handschuh, K. Stephens, E. Peppel, H. Krehbiel, V. Brisson, J. P. Kubenka, C. Thiebaux, G. Buschhorn, G. W. Noyes, P. Dingus, J. Feltesse, Max Klein, P. A. Smirnov, F. Charles, I. Sheviakov, U. Krüger, J. Stier, J. Marks, S. Dagoret, Y. Vazdik, H. Bergstein, Th. Naumann, Vladimir Andreev, H. U. Martyn, H. Duhm, V I. Shekelyan, R. Haydar, P. C. Bosetti, E. Gabathuler, E. Deffur, K. Wacker, P. Ribarics, R. Steinberg, Y. Soloviev, J. Moreels, T. R. Ebert, Dusan Bruncko, P. E. Reimer, Alan Campbell, E. M. Hanlon, G. G. Winter, A. Fedotov, Günter Flügge, T. P. Yiou, P. Steffen, B. Naroska, F. Ferrarotto, H. P. Wellisch, C. Kiesling, A. De Roeck, T. Carli, Richard E. Taylor, F. Ould-Saada, H. Genzel, L. Urban, T. Kurča, T. Greenshaw, J.P. Phillips, Rosario Martín, J. Ferencei, P. Van Esch, A. Rostovtsev, Claus Kleinwort, S. Reinshagen, M. Arpagaus, W. Hildesheim, S. Willard, M. Winde, L. Johnson, D. Feeken, A. Valkarova, S. A. Murray, Martin Erdmann, U. Obrock, F. Niebergall, and M. P. J. Landon

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Range (particle radiation), Luminosity (scattering theory), Neutral current, Proton, Detector, Elementary particle, HERA, Atomic physics, Deep inelastic scattering
Abstract

A measurement of the proton structure function F2 (x, Q2) is presented with about 1000 neutral current deep inelastic scattering events for Bjorken x in the range x ⋍ 10−2 – 10−4 and Q2 > 5 GeV2. The measurement is based on an integrated luminosity of 22.5 nb−1 recorded by the H1 detector in the first year of HERA operation. The structure function F2 (x, Q2) shows a significant rise with decreasing x.

Published
1993

117. Measurement of inclusive jet cross sections in photoproduction at HERA

Author

J. Duboc, B. Stella, Kerstin Borras, A. Lebedev, A. Semenov, M. Rietz, C. Vallée, M. Colombo, R. D. Appuhn, Vladimir Andreev, H. Greif, M. Gennis, N. Magnussen, G. Lindström, C. Gruber, W. Flauger, H. Bergstein, S. D. Kolya, D. Haidt, Th. Naumann, F. Brasse, R. C. W. Henderson, M. Rudowicz, N. Sahlmann, Murrough Landon, A. E. Wright, H. Duhm, J-P. Meyer, P. Biddulph, R. Ebbinghaus, W. von Schlippe, T. Merz, M. Ibbotson, E. Deffur, K. C. Hoeger, G. Heinzelmann, M. A. Jabiol, J. Tutas, J. D. Burger, F. Ould-Saada, R. Prosi, F. Zomer, A. M. Goodall, R. Bernet, P. Kostka, A. Buniatian, M. Jaffre, P. Ribarics, D. Wegener, W.J. Haynes, U. Bassler, M. Fleischer, Leith Godfrey, C. Kiesling, H. Itterbeck, S. Peters, V. Riech, Armen Vartapetian, J. E. Olsson, W. Bartel, E. Malinovski, M. Kuhlen, Y. Soloviev, L. Del Buono, V. Milone, S. Kasarian, S. A. Murray, H. Küster, J. Feltesse, M. Hapke, K. Rauschnabel, Wolfgang Lange, Leif J. Jönsson, R. Roosen, Emmanuel Monnier, T. Köhler, M. W. Krasny, Mario David, E. Binder, J. V. Morris, V. Efremenko, H. Lohmander, G. Siegmon, Martin Erdmann, R. Felst, U. Obrock, Grzegorz Nowak, C. Jacobsson, M. Eberle, M. Korn, L.A. Womersley, R. Nisius, F. W. Büsser, M. Arpagaus, W. Braunschweig, F. Niebergall, V. Korbel, J. Stier, K. Rybicki, Vincent Hedberg, G. Knies, L. Smolik, U. Seehausen, K. Johannsen, S. Mikocki, M. Forbush, Max Klein, R. L. Lander, R. J. Ellison, J. Marks, R. Gerhards, J. M. Foster, H. Bärwolff, Y. Vazdik, J. Riedlberger, A. Schwind, R. Sell, E. Sanchez, G. Weber, U. Straumann, M. Nyberg, T. Ahmed, Th. Wolff, P. E. Reimer, Christophe Royon, F. Moreau, L. N. Shtarkov, J. D. Dowell, C. A. Meyer, M. Vecko, J. R. Smith, I. R. Kenyon, Alan Campbell, J. Harjes, J. Moreels, J. Haack, E. M. Hanlon, S. M. Robertson, R. Herma, W. Hildesheim, H. U. Martyn, U. Siewert, I. O. Skillicorn, T. R. Ebert, A. Walther, A. Jacholkowska, H. Spitzer, D. Mercer, G. G. Winter, M. Savitsky, H. B. Dreis, P. A. Smirnov, K. Meier, J. Turnau, A. Fedotov, B. Naroska, Winston Ko, Yves Sirois, P. Fuhrmann, G. Grindhammer, F. Linsel, Günter Flügge, T. P. Yiou, M. Zimmer, S. Willard, P. Baranov, C. Zeitnitz, S. Eichenberger, Dave Sankey, P. Steffen, J. Martens, C. Pascaud, Tim Greenshaw, Jean-Francois Laporte, W. Zimmermann, M. Steenbock, A. De Roeck, Richard E. Taylor, A. Valkarova, J. Heatherington, F. Kole, Guenter Eckerlin, L. Goerlich, Peter Robmann, Peter Schleper, Michel Devel, S. Kermiche, L. Urban, S. Masson, L. Criegee, H. Henschel, T. Kurča, J. Lipinski, R. Vick, D. Newton, G. D. Patel, G. Franke, B. Andrieu, H. Meyer, W. Scobel, A. Bischoff, D.P. Johnson, A. Gellrich, H. P. Wellisch, H. Shooshtari, M. Winde, S. Rusakov, J. Formánek, L. Johnson, F. Lamarche, R. Kaschowitz, J. Cvach, P. Lanius, T. Carli, R. Langkau, T. Jansen, P. Goritchev, V. Tchernyshov, S. Riess, S. Egli, Frank Raupach, Marc Besancon, W.D. Dau, U. Kathage, J. B. Dainton, O. Dünger, K. Gamerdinger, A.S. Belousov, P. Hill, Hermann Kolanoski, D. Clarke, G. Rädel, H.T. Phillips, M. Schulz, B. Kuznik, J. Bán, John A Coughlan, D. Neyret, Claire Bourdarios, J.C. Phillips, K. Stephens, E. Peppel, J. Gayler, P. Truöl, Horst Oberlack, N. Wulff, J. Garvey, Mikhail Danilov, I. Abt, E. Gabathuler, Nicolas Ellis, Ph. Huet, D. Lewin, Stephen Maxfield, Ch. Pichler, J. Žáček, A. M. Fomenko, I. W. Walker, E. Eisenhandler, P. Kasselmann, R. Marshall, S. Prell, A. Leuschner, Christoph Grab, Dirk Krücker, A. B. Clegg, Andrew Mehta, D. Handschuh, H. Krehbiel, J. Martyniak, D. Feeken, G. Buschhorn, S. Levonian, S. Mani, B. Fominykh, N. Huot, D. Lüers, E. Barrelet, H. P. Beck, Stephen Burke, P. Dingus, Pavel Staroba, P. Verrecchia, M. Ruffer, V. Schröder, S. Orenstein, Ch. Berger, H. H. Kaufmann, K. Flamm, Eckhart Fretwurst, A. Mavroidis, L. Büngener, I. Tichomirov, C. Schmidt, J. P. Sutton, U. Braun, J. Ebert, P. I. P. Kalmus, I. Herynek, H. Hufnagel, A. Usik, Ch. Ley, C.D. Hilton, H. K. Nguyen, I. V. Gorelov, K. Müller, R. Grässler, Ch. Coutures, W. Struczinski, D. Schmidt, Peter Schacht, G. C. Lopez, W. Schmitz, E. Vogel, Gregorio Bernardi, V. Boudry, Anton Babaev, C. Thiebaux, J. Strachota, I.F. Fensome, A. Lindner, Volker Blobel, C. Keuker, Petr Zavada, Pavel Murin, V. Brisson, H. Grässler, Laurent Favart, C. Dollfus, F. Charles, I. Sheviakov, Ulrich Goerlach, U. Krüger, S. Dagoret, G. Cozzika, F. Eisele, J. Hladký, Stefan Valkar, Hannes Jung, V I. Shekelyan, R. Haydar, P. C. Bosetti, K. Wacker, R. Steinberg, E. Evrard, Dusan Bruncko, F. Ferrarotto, B. Delcourt, H. Genzel, U. Stösslein, C. Leverenz, O. Hamon, Rosario Martín, J. Ferencei, P. Van Esch, E. Elsen, A. Rostovtsev, Claus Kleinwort, G. Bertrand-Coremans, G. Thompson, A. Wegner, H. Ziaeepour, J. Kurzhöfer, V. Nagovizin, A. W. E. Dann, D. Düllmann, R. Eichler, J. P. Kubenka, G. W. Noyes, H. J. Behrend, J.C. Bizot, M. Goldberg, Steve McMahon, A. Drescher, G. Villet, Pierre Marage, A. Courau, Daniel Pitzl, S. K. Kotelnikov, L. Hajduk, Peter Loch, W. Pilgram, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), H1, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Damoiseaux, Magali

Subjects
Nuclear and High Energy Physics, Particle physics, Photon, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, FOS: Physical sciences, Elementary particle, 7. Clean energy, 01 natural sciences, High Energy Physics - Experiment, Nuclear physics, High Energy Physics - Experiment (hep-ex), 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Perpendicular, 010306 general physics, Nuclear Experiment, Engineering (miscellaneous), Physics, Quantum chromodynamics, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Detector, Perturbative QCD, HERA, Transverse plane, Pseudorapidity, High Energy Physics::Experiment, Underlying event
Abstract

Inclusive jet cross sections are measured in photoproduction at HERA using the H1 detector. The data sample of e+ p -> e+ + jet + X events in the kinematic range of photon virtualities Q^2 < 1 GeV^2 and photon-proton centre-of-mass energies 95 < W_gammap < 285 GeV represents an integrated luminosity of 24.1 pb^-1. Jets are defined using the inclusive k_T algorithm. Single- and multi-differential cross sections are measured as functions of jet transverse energy E_T^jet and pseudorapidity ��^jet in the domain 5 < E_T^jet < 75 GeV and -1 < ��^jet < 2.5. The cross sections are found to be in good agreement with next-to-leading order perturbative QCD calculations corrected for fragmentation and underlying event effects. The cross section differential in E_T^jet, which varies by six orders of magnitude over the measured range, is compared with similar distributions from p pbar colliders at equal and higher energies., 34 pages, 9 figures and 7 tables

Published
1993

118. A search for leptoquarks, leptogluons and excited leptons in H1 at HERA

Author

C. Jacobsson, Leith Godfrey, M. Savitsky, Th. Wolff, G. Villet, Pierre Marage, I. R. Kenyon, E. Malinovski, M. Kuhlen, E. Evrard, H. Spitzer, G. Siegmon, C. Zeitnitz, Dave Sankey, G. D. Patel, H. Meyer, W. Scobel, L. Smolik, U. Seehausen, D.P. Johnson, R. Nisius, M. W. Krasny, J. Cvach, A. Courau, M. Colombo, Murrough Landon, J. V. Morris, Michel Devel, U. Kathage, J. Riedlberger, M. Vecko, T. Ahmed, M. Jaffre, W. Ko, J. E. Olsson, W. Bartel, C. A. Meyer, H. U. Martyn, B. Delcourt, M. Forbush, A. Schwind, M. Nyberg, J. Harjes, A. E. Wright, F. Moreau, J. Hladký, J. D. Dowell, S. M. Robertson, Kerstin Borras, U. Stösslein, J. Garvey, A. Semenov, P. Baranov, R. J. Ellison, R. Bernet, A. Jacholkowska, F. W. Büsser, P. Goritchev, E. Gabathuler, C. Leverenz, A. M. Fomenko, W. Braunschweig, P. Fuhrmann, A. Lebedev, F. Charles, M. Rietz, I. Sheviakov, D. Haidt, Peter Schleper, O. Hamon, K. Gamerdinger, R. Sell, R. Herma, I. O. Skillicorn, S. J. McMahon, D. Neyret, L. Goerlich, Andrew Mehta, J. Moreels, G. Heinzelmann, F. Brasse, Leif J. Jönsson, D. Handschuh, H. Itterbeck, S. Peters, U. Krüger, M. Fleischer, U. Siewert, J-P. Meyer, H. Küster, S. Masson, U. Bassler, G. Cozzika, Marc Besancon, E. Barrelet, N. Huot, S. A. Murray, M. Zimmer, W. von Schlippe, A.S. Belousov, F. Eisele, T. Merz, Daniel Pitzl, J. Žáček, S. Dagoret, H. Lohmander, V. Milone, H. Krehbiel, K. Johannsen, J.P. Phillips, Stefan Valkar, M. Ibbotson, T. Jansen, P. Truöl, I. Tichomirov, Christophe Royon, M. Ruffer, Ch. Berger, S. Orenstein, T. R. Ebert, F. Raupach, P. I. P. Kalmus, S. Kasarian, J. Ferencei, V I. Shekelyan, R. Haydar, P. C. Bosetti, G. Rädel, R. Felst, S. K. Kotelnikov, L. Hajduk, C. Trenkel, Hannes Jung, D. Gillespie, B. Kuznik, L. Büngener, Armen Vartapetian, C. Vallée, M. Eberle, Mario David, K. Wacker, R. Steinberg, P. Závada, Ph. Huet, B. Naroska, G. Buschborn, J. M. Foster, Vincent Hedberg, G. Knies, H. Hufnagel, J. Ebert, Hermann Kolanoski, I. Herynek, D. Clarke, M. Korn, R. D. Appuhn, Ch. Pichler, S. Mani, Pavel Murin, D. Mercer, V. Brisson, John A Coughlan, A. Fedotov, G. Nowak, T. P. Yiou, C. Pascaud, H. Grässler, Guenter Eckerlin, R. Vick, Peter Loch, Dusan Bruncko, Martin Erdmann, H. P. Beck, U. Obrock, Stephen Burke, H. Shooshtari, R. D. Martin, F. Niebergall, V. Korbel, N. Wulff, D. Lüers, J. Haack, F. Ferrarotto, W. Pilgram, H. Genzel, M. Gennis, S. Kermiche, Ch. Ley, J. Tutas, J. D. Burger, P. Kasselmann, G. Thompson, R. Prosi, J. Duboc, B. Stella, N. Magnussen, H. Greif, C.D. Hilton, H. B. Dreis, N. Sahlmann, Pavel Staroba, G. Lindström, C. Gruber, S. J. Maxfield, F. Zomer, A. M. Goodall, M. Rudowicz, W. Flauger, R. Langkau, D. Düllmann, P. Biddulph, L. Del Buono, R. Ebbinghaus, A. De Roeck, P. Van Esch, E. Elsen, I. Abt, Richard E. Taylor, H. J. Behrend, J.C. Bizot, A. Rostovtsev, Claus Kleinwort, M. Goldberg, M. A. Jabiol, S. Eichenberger, G. Bertrand-Coremans, H. K. Nguyen, I. V. Gorelov, K. Müller, Mikhail Danilov, D. Lewin, V. Schröder, A. Drescher, R. Grässler, Ch. Coutures, W. Struczinski, L. Urban, Laurent Favart, H. Henschel, A. Wegner, H. Oberlack, Yves Sirois, A. Valkarova, H. H. Kaufmann, S. Egli, G. Weber, T. Kurča, H. Bärwolff, H. Ziaeepour, J. Kurzhöfer, U. Straumann, V. Nagovizin, A. W. E. Dann, C. Dollfus, L. Criegee, S. Levonian, R. Eichler, J. Martyniak, J. P. Kubenka, A. Usik, J. Lipinski, G. Franke, C. Thiebaux, A. B. Clegg, Vladimir Andreev, B. Fominykh, L.A. Womersley, G. W. Noyes, G. Flügge, I. W. Walker, K. Flamm, P. Schacht, R. Kaschowitz, A. Leuschner, Christoph Grab, A. Mavroidis, S. Rusakov, J. Formánek, A. Walther, J. Stier, Ulrich Goerlach, J. Marks, Y. Vazdik, W. Zimmermann, A. Gellrich, P. Verrecchia, H. Bergstein, S. D. Kolya, Th. Naumann, F. Ould-Saada, H. Duhm, H.T. Phillips, M. Schulz, E. Deffur, I.F. Fensome, P. Kostka, J. Gayler, J. F. Laporte, P. Ribarics, Y. Soloviev, E. Fretwurst, Tim Greenshaw, A. Buniatian, D. Wegener, W.J. Haynes, A. Lindner, R. Roosen, R. Marshall, P. Hill, J. Bán, J. Heatherington, Emmanuel Monnier, T. Köhler, Volker Blobel, C. Keuker, D. Newton, V. Efremenko, S. Mikocki, Nicolas Ellis, D. Schmidt, M. Seman, P. Lanius, G. C. Lopez, W. Schmitz, V. Tchernyshov, E. Vogel, J. Turnau, V. Boudry, Anton Babaev, J. Strachota, M. Steenbock, B. Andrieu, G. Bernardi, D. Krücker, K. C. Hoeger, V. Riech, M. Hapke, C. Schmidt, J. P. Sutton, U. Braun, R. Gerhards, P. E. Reimer, Alan Campbell, E. M. Hanlon, G. G. Winter, K. Rauschnabel, Wolfgang Lange, G. Grindhammer, P. Steffen, E. Binder, H. P. Wellisch, T. Carli, E. Sanchez, Peter Robmann, A. Bischoff, W. Hildesheim, R. C. W. Henderson, J. R. Smith, S. Willard, O. Dünger, M. Winde, J. P. Pharabod, L. Johnson, C. Kiesling, M. Arpagaus, K. Rybicki, Richard Lander, K. Stephens, E. Peppel, E. Eisenhandler, P. Dingus, J. Martens, F. Kole, W.D. Dau, J. B. Dainton, Claire Bourdarios, J. Feltesse, Max Klein, D. Feeken, P. A. Smirnov, and K. Meier

Subjects
Quark, Physics, Nuclear and High Energy Physics, Particle physics, Branching fraction, High Energy Physics::Phenomenology, Elementary particle, HERA, Nuclear physics, Excited state, High Energy Physics::Experiment, Leptoquark, Neutrino, Lepton
Abstract

A direct search for new particles in the H1 experiment at HERA is presented for masses ranging from 35 GeV up to ∼ 250 GeV. The data sample of 24 nb −1 accumulated during the first year of operation was analysed for signatures of scalar and vector leptoquarks, leptogluons, excited electrons and excited neutrinos with flavours of the first generation. No evidence for the production of such particles was found in various possible decay channels. Rejection limits are derived.

Published
1993

119. Effect of Early Antibiotic Treatment on the Formation of Sperm Antibodies in Experimentally Induced Epididymitis

Author

L. M. Nyberg, F. Greskovich, Subbi Mathur, and B. S. Collins

Subjects
Male, medicine.medical_specialty, medicine.drug_class, Antibiotics, Biology, Endocrinology, Immunity, Internal medicine, Testis, Escherichia coli, medicine, Animals, Autoantibodies, Epididymis, Epididymitis, Antibody titer, Tetracycline, medicine.disease, Spermatozoa, Sperm, Rats, Titer, medicine.anatomical_structure, Rats, Inbred Lew, biology.protein, Antibody
Abstract

This investigation was conducted to evaluate whether or not experimentally produced epididymitis could induce the development of cytotoxic sperm antibodies and if effective antibiotic therapy could reverse the development of immunity to sperm. Escherichia coli was injected into the tail of the epididymis in adult Lewis rats to induce epididymitis and was allowed to incubate for 24 h, 72 h, 8 days, or 15 days. Serum titers of cytotoxic sperm antibodies at these time intervals were determined. Sperm antibody titers began to rise 3 days after inoculation, peaked, and plateaued at 8 days. The titers were negligible in the control rats. Two other groups of rats were inoculated with E. coli in a similar manner and were treated with tetracycline 25 mg/kg/day starting at either 24 h or 8 days after inoculation, for 7 days. The antibody titers became negligible in these two treated groups, the results being statistically significant when contrasted with the infected but untreated groups (p.001 and.05, respectively, for the 24-h and 8-day groups). However, histological examination of the antibiotic-treated and untreated specimens revealed significant inflammation and infection of the epididymis in both treated groups. Testicular alterations were consistent in both groups. It is concluded that epididymitis consequent to infection with E. coli can induce cytotoxic antibody formation in Lewis rats. Treatment with appropriate antibiotics may suppress the antibody response either through a direct immunosuppressive effect of the antibiotic or through a decrease in the antigenic load of killed sperm secondary to eradication of the infection.

Published
1993

120. Observation of deep inelastic scattering at low x

Author

F. W. Büsser, W. Braunschweig, R. Sell, Grzegorz Nowak, G. Cozzika, C. Jacobsson, U. Siewert, M. Zimmer, E. Malinovski, Stefan Valkar, Vincent Boudry, Jean-Francois Laporte, M. Kuhlen, G. Grindhammer, Hannes Jung, C. Vallée, U. Kathage, P. E. Reimer, P. S. Flower, Alan Campbell, E. M. Hanlon, E. Eisenhandler, P. Staroba, G. G. Winter, Vincent Hedberg, J. Turnau, G. Knies, Leif J. Jönsson, M. Steenbock, G. Bertrand-Coremans, P. Steffen, Kerstin Borras, A. Semenov, G. Thompson, F. Brasse, P. Hartz, R. J. Ellison, B. Andrieu, E. Barrelet, H. Lohmander, A. Wegner, H. P. Wellisch, R. Hedgecock, A. Gellrich, R. Kaschowitz, U. Bassler, J. Moreels, D. Düllmann, Ch. Berger, Karlheinz Meier, C. Trenkel, H. Shooshtari, J. Haack, I. O. Skillicorn, P. Zavada, M. Vecko, K. C. Hoeger, D. Handschuh, I. W. Walker, H. Krehbiel, H. Ziaeepour, J. Kurzhöfer, V. Nagovizin, A. W. E. Dann, R. Eichler, J. P. Kubenka, A. Buniatian, D. Wegener, W.J. Haynes, I. Herynek, K. Rybicki, H. Henschel, M. Gennis, Ch. Ley, Hans Peter Beck, A. Leuschner, Christoph Grab, H. J. Behrend, J.C. Bizot, Frank Raupach, M. Goldberg, H. B. Dreis, M. Colombo, V. Riech, U. Berthon, V. Milone, W.D. Dau, E. Evrard, G. W. Noyes, G. Lindström, P. Hill, J. Bán, C. Gruber, R. Roosen, Emmanuel Monnier, W. Flauger, T. Ahmed, Th. Wolff, Murrough Landon, F. Charles, N. Wulff, A. E. Wright, V. Korbel, I. Sheviakov, M. Hapke, T. Köhler, M. W. Krasny, Armen Vartapetian, P. Kasselmann, H. U. Martyn, Matthias Klein, R. C. W. Henderson, Peter Schacht, G. C. Lopez, U. Krüger, Nicolas Ellis, H. Küster, W. Schmitz, B. Delcourt, R. Felst, G. Bushhorn, M. Eberle, I. R. Kenyon, V. Efremenko, F. Zomer, A. M. Goodall, U. Gensch, E. Vogel, Gregorio Bernardi, P. Baranov, Anton Babaev, C. Leverenz, J. Hladký, S. Eichenberger, H. K. Nguyen, O. Hamon, Jean-Arcady Meyer, H.T. Phillips, V I. Shekelyan, R. Haydar, P. C. Bosetti, H. Spitzer, M. Schulz, I. V. Gorelov, K. Müller, J. D. Burger, S. Peters, C. Schmidt, J. Strachota, U. Braun, S. Mikocki, Peter Schleper, K. Wacker, R. Steinberg, R. Grässler, Ch. Coutures, W. Struczinski, Stephen Maxfield, I.F. Fensome, Hermann Kolanoski, R. Prosi, T. R. Ebert, D. Clarke, R. Gerhards, R. Marshall, Dirk Krücker, A. Lindner, K. Rauschnabel, A. Usik, E. Binder, A. B. Clegg, Andrew Mehta, L. Del Buono, Marc Besancon, J. Gayler, Michel Devel, A.S. Belousov, Sergey Rusakov, S. Kermiche, V. Andreev, Volker Blobel, L.A. Womersley, F. Ould-Saada, E. Sanchez, Dusan Bruncko, R. L. Lander, H. Bärwolff, B. Naroska, F. Ferrarotto, P. Truöl, A. Walther, H. Genzel, I. Tichomirov, John A Coughlan, Horst Oberlack, W. Zimmermann, Peter Robmann, M. Ruffer, S. A. Murray, T. Greenshaw, N. Magnussen, S. Orenstein, A. Fedotov, Günter Flügge, T. P. Yiou, J.P. Phillips, Pavel Murin, V. Brisson, H. Grässler, Rosario Martín, J. Ferencei, L. Criegee, H. Hufnagel, P. Van Esch, J. Sacton, N. Sahlmann, A. Rostovtsev, Claus Kleinwort, J. Ebert, O. Dünger, M. Ibbotson, Martin Erdmann, U. Obrock, J. M. Foster, J. Formánek, P. Biddulph, B. Kuznik, M. A. Jabiol, F. Niebergall, Ph. Huet, C.D. Hilton, M. Savitsky, Ch. Pichler, W. von Schlippe, G. Siegmon, C. A. Meyer, T. Merz, J. Cvach, F. Moreau, P. Fuhrmann, J. D. Dowell, R. J. Thompson, Yves Sirois, A. Jacholkowska, Mikhail Danilov, S. D. Kolya, H. Steiner, L. Goerlich, A. Valkarova, D. Levin, J. Martyniak, C. Kiesling, Roland Bernet, S. Kasarian, B. Fominykh, J. Riedlberger, M. Nyberg, J. Harjes, S. M. Robertson, Eckhart Fretwurst, A. De Roeck, Mario David, G. Franke, Richard E. Taylor, R. Nisius, J. R. Smith, L. Urban, S. Mani, R. Herma, Stephen Burke, J. Duboc, B. Stella, T. Kurča, H. Greif, P. Goritchev, K. Gamerdinger, M. Rudowicz, J. Stier, Leith Godfrey, J. Marks, Y. Vazdik, H. Bergstein, C. Zeitnitz, Th. Naumann, Dave Sankey, H. Duhm, E. Gabathuler, E. Deffur, J.M. Morton, P. Kostka, G. D. Patel, P. Ribarics, Y. Soloviev, H. Meyer, W. Scobel, D.P. Johnson, David Schmidt, T. Carli, A. Lebedev, S. Egli, S. Masson, M. Rietz, D. Haidt, G. Heinzelmann, J.P. Sutton, J. V. Morris, D. Lüers, M. Forbush, A. Schwind, P. Verrecchia, V. Schröder, S. Levonian, H. H. Kaufmann, Eckhard Elsen, A. Mavroidis, P. I. P. Kalmus, Y. Feng, G. A. Beck, J. Garvey, A. M. Fomenko, N. Huot, W. Hildesheim, S. Willard, M. Winde, L. Johnson, M. Fleischer, K. Stephens, E. Peppel, M. Arpagaus, L. Smolik, U. Seehausen, K. Johannsen, J. Zacek, Christophe Royon, D. Gillespie, C. Pascaud, Guenter Eckerlin, R. Vick, J. Tutas, D. Feeken, R. Langkau, Laurent Favart, C. Dollfus, E. Ryseck, Ulrich Goerlach, M. Korn, G. Weber, U. Straumann, P. Dingus, J. Heatherington, D. Newton, Daniel Pitzl, M. Seman, P. Lanius, V. Tchernyshov, J. Martens, F. Kole, S. K. Kotelnikov, L. Hajduk, Peter Loch, J. B. Dainton, W. Pilgram, Claire Bourdarios, J. Feltesse, G. Villet, Pierre Marage, A. Courau, P. A. Smirnov, F. Eisele, Steve McMahon, A. Drescher, M. Jaffre, J. E. Olsson, and W. Bartel

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Luminosity (scattering theory), Proton, Neutral current, Scattering, High Energy Physics::Experiment, Elementary particle, Electron, HERA, Nuclear Experiment, Deep inelastic scattering
Abstract

Measurements of the scattered electron energy spectrum and the differential cross sections dσ/d log(x) and dσ/dQ2 for inclusive neutral current deep inelastic electron-proton scattering are presented. The data were obtained with the H1 detector at HERA during its first running period in which 26.7 GeV electrons collided with 820 GeV protons. The data correspond to an integrated luminosity of 1.3 nb−1 and allow the first studies of the structure of the proton at values of x down to 10−4 for Q2 > 5 GeV2.

Published
1993

121. Total photoproduction cross section measurement at HERA energies

Author

J. D. Burger, M. Colombo, R. Prosi, I.F. Fensome, P. S. Flower, Murrough Landon, A. Lindner, F. Zomer, A. M. Goodall, A. E. Wright, Max Klein, J. M. Foster, Volker Blobel, C. Kiesling, L. Del Buono, M. Savitsky, Leif J. Jönsson, K. C. Hoeger, J. Hladký, D. Schmidt, M. Nyberg, S. Levonian, S. Peters, H. Lohmander, P. A. Smirnov, K. Meier, G. Cozzika, F. Eisele, P. Závada, V. Riech, Peter Schacht, G. C. Lopez, H. Küster, W. Schmitz, J. Cvach, M. Arpagaus, K. Rybicki, T. Ahmed, J.P. Phillips, E. Vogel, Gregorio Bernardi, V. Boudry, Anton Babaev, M. Hapke, K. Stephens, E. Peppel, R. Nisius, R. J. Thompson, Yves Sirois, A. Usik, J. Strachota, Hannes Jung, P. Baranov, B. Kuznik, N. Magnussen, W. Hildesheim, Roland Bernet, N. Sahlmann, Ph. Huet, E. Eisenhandler, Ch. Pichler, Peter Schleper, G. Villet, S. Egli, S. Willard, Pavel Murin, V. Brisson, E. Evrard, G. Franke, H. Grässler, H. Bergstein, J. Riedlberger, Th. Wolff, Stephen Maxfield, J. Harjes, S. M. Robertson, Vincent Hedberg, G. Knies, G. Siegmon, A. Buniatian, Pierre Marage, M. Jaffre, J. E. Olsson, W. Bartel, S. D. Kolya, Th. Naumann, J. Turnau, P. Biddulph, Laurent Favart, P. Dingus, A. B. Clegg, Andrew Mehta, I. R. Kenyon, R. Gerhards, J. Martens, H. Spitzer, D. Wegener, W.J. Haynes, M. Steenbock, F. W. Büsser, Marc Besancon, A.S. Belousov, W. Braunschweig, C. Dollfus, P. Truöl, R. Roosen, A. Courau, M. Winde, B. Delcourt, Emmanuel Monnier, R. Sell, L. Johnson, Ulrich Goerlach, M. Korn, M. A. Jabiol, P. Staroba, I. W. Walker, J. Haack, F. Moreau, J. D. Dowell, P. Goritchev, H. Duhm, U. Siewert, I. Tichomirov, Grazyna Nowak, M. Zimmer, R. Herma, P. E. Reimer, T. Köhler, B. Andrieu, C. Leverenz, A. Leuschner, Christoph Grab, G. Weber, M. Ruffer, Jean-Francois Laporte, S. Orenstein, Michel Devel, I. O. Skillicorn, H. B. Dreis, A. Jacholkowska, S. Mani, M. Vecko, K. Gamerdinger, E. Barrelet, O. Hamon, U. Straumann, Alan Campbell, E. M. Hanlon, J. B. Dainton, Claire Bourdarios, J. Zacek, J. Ebert, A. Gellrich, G. G. Winter, H. Hufnagel, V. Efremenko, E. Deffur, U. Berthon, Frank Raupach, Armen Vartapetian, G. Grindhammer, H. Shooshtari, C. A. Meyer, J. Heatherington, P. Steffen, H. U. Martyn, S. Mikocki, J.M. Morton, N. Wulff, P. Kostka, P. Ribarics, Ch. Ley, Hermann Kolanoski, D. Clarke, John A Coughlan, P. Kasselmann, P. Fuhrmann, C.D. Hilton, G. Thompson, Ch. Berger, Horst Oberlack, Y. Soloviev, H. P. Wellisch, J. Duboc, B. Stella, D. Feeken, H. Greif, S. Kermiche, L. Goerlich, M. Rudowicz, C. Trenkel, D. Düllmann, Mikhail Danilov, H. Steiner, S. Eichenberger, Stephen Burke, U. Bassler, R. L. Lander, H. Bärwolff, Daniel Pitzl, H. J. Behrend, J.C. Bizot, M. Goldberg, L. Criegee, R. Kaschowitz, D. Levin, J. Martyniak, H. K. Nguyen, I. V. Gorelov, K. Müller, V. Milone, W.D. Dau, A. Mavroidis, R. Grässler, Ch. Coutures, W. Struczinski, F. Kole, E. Ryseck, S. Rusakov, J. Formánek, B. Fominykh, Tim Greenshaw, S. K. Kotelnikov, L. Hajduk, R. Felst, P. I. P. Kalmus, M. Eberle, I. Herynek, J. Moreels, Eckhart Fretwurst, J-P. Meyer, Peter Loch, Hans Peter Beck, D. Newton, W. Pilgram, T. Merz, M. Ibbotson, C. Jacobsson, Steve McMahon, T. R. Ebert, M. Seman, S. Kasarian, P. Lanius, P. Hill, J. Bán, V. Tchernyshov, Mario David, A. Fedotov, A. Drescher, M. W. Krasny, Günter Flügge, T. P. Yiou, U. Kathage, E. Malinovski, M. Kuhlen, E. Gabathuler, Nicolas Ellis, Kerstin Borras, A. Semenov, F. Brasse, A. De Roeck, P. Hartz, R. J. Ellison, R. Hedgecock, C. Vallée, Richard E. Taylor, J.R. Smith, M. Gennis, G. Lindström, C. Gruber, W. Flauger, L. Urban, H. Henschel, T. Kurča, J. Stier, J. Marks, Y. Vazdik, G. Bertrand-Coremans, A. Wegner, H. Ziaeepour, J. Kurzhöfer, V. Nagovizin, A. W. E. Dann, R. Eichler, J. P. Kubenka, G. W. Noyes, Peter Robmann, W. von Schlippe, L. Smolik, U. Seehausen, K. Johannsen, F. Charles, Christophe Royon, I. Sheviakov, D. Gillespie, U. Krüger, B. Naroska, J. Sacton, C. Pascaud, Guenter Eckerlin, R. Vick, J. Tutas, V I. Shekelyan, R. Haydar, P. C. Bosetti, O. Dünger, R. Langkau, K. Wacker, R. Steinberg, G. A. Beck, J. Garvey, A. M. Fomenko, Dusan Bruncko, S. A. Murray, F. Ferrarotto, H. Genzel, N. Huot, K. Rauschnabel, E. Binder, Martin Erdmann, H. Obrock, Rosario Martín, F. Niebergall, V. Korbel, J. Ferencei, P. Van Esch, E. Elsen, E. Sanchez, A. Rostovtsev, Claus Kleinwort, L.A. Womersley, A. Valkarova, Vladimir Andreev, U. Gensch, A. Walther, F. Ould-Saada, C. Schmidt, U. Braun, W. Zimmermann, D. Handschuh, H. Krehbiel, D. Lüers, P. Verrecchia, G. Buschhorn, V. Schröder, H. H. Kaufmann, Leith Godfrey, H.T. Phillips, M. Schulz, J. Gayler, S. Masson, R. Marshall, Dirk Krücker, J. V. Morris, Y. Feng, M. Forbush, A. Schwind, A. Lebedev, M. Rietz, D. Haidt, G. Heinzelmann, M. Fleischer, J.P. Sutton, S. Valkar, C. Zeitnitz, Dave Sankey, G. D. Patel, H. Meyer, W. Scobel, D.P. Johnson, T. Carli, R. C. W. Henderson, and J. Feltesse

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Range (particle radiation), Photon, Hadron, Elementary particle, Electron, HERA, Nuclear physics, Cross section (physics), High Energy Physics::Experiment, Center of mass, Nuclear Experiment
Abstract

We present first results on the total photoproduction cross section measurement with the H1 detector at HERA. The data were extracted from low Q2 collisions of 26.7 GeV electrons with 820 GeV protons. The γp total cross section has been measured by two independent methods in the γp center of mass energy range from 90 to 290 GeV. For an average center of mass energy of 195 GeV a value of σtot (γp) = 159 ± 7 (stat.) ± 20 (syst.) μb was obtained.

Published
1993

122. Commentaries on health services research

Author

Jennifer Coombs, Sue M. Nyberg, and Mary L. Warner

Subjects
medicine.medical_specialty, business.industry, Obstetrics, Medicine, Abortion, business, Nurse Assisting
Published
2014

123. Immune response to influenza vaccine in adult liver transplant recipients

Author

Lisa M. Nyberg, R. Michael Hendry, M. Eric Viernes, Paul J. Pockros, and Andrea Duchini

Subjects
Adult, Liver Cirrhosis, Male, Cirrhosis, Influenza vaccine, medicine.medical_treatment, Liver transplantation, Antibodies, Viral, Immune system, Influenza, Human, medicine, Humans, Seroconversion, Aged, Transplantation, Hepatology, business.industry, Antibody titer, Middle Aged, medicine.disease, Liver Transplantation, Vaccination, Influenza Vaccines, Antibody Formation, Immunology, Female, Surgery, business
Abstract

Influenza virus infection may cause significant complications in liver transplant recipients, and whether vaccination is effective in these patients is controversial. We performed a study to assess the immune response to influenza vaccine in liver transplant recipients and patients with cirrhosis compared with healthy controls. Liver transplant recipients (n = 20), patients with compensated cirrhosis awaiting transplantation (n = 14), and healthy volunteers (n = 9) were administered the standard dose of the 1999 to 2000 inactivated trivalent vaccine (A/Bejing/262/95[H1N1]; A/Sidney/5/97[H3N2]; B/Yamanashi/166/98). Antibody responses to each component of the vaccine were measured at baseline and after 6 weeks by hemagglutination inhibition. Vaccination was well tolerated, and no major side effects were observed. A significant postvaccination increase in antibody titer to all 3 vaccine components was obtained in all groups. However, liver transplant recipients had significantly lower postvaccination geometric mean titers and geometric mean increases to the H3N2 component compared with patients with cirrhosis and controls. The rate of seroconversion to H3N2 after vaccination was also significantly lower in liver transplant recipients (15% v. 89%). We conclude that liver transplant recipients have a significantly impaired immune response to the influenza vaccine, and some patients may remain unprotected from influenza infection after vaccination. Further studies of modified protocols of influenza vaccination for these patients are recommended.

Published
2001

124. Pregabalin for the Treatment of Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Randomized Controlled Trial

Author

John W. Kusek, Anthony J. Schaeffer, Richard B. Alexander, Rodney U. Anderson, Mary McNaughton-Collins, John N. Krieger, Shannon Chuai, Daniel A. Shoskes, Michel A. Pontari, Kathleen J. Propert, Scott I. Zeitlin, Paige C. White, Liyi Cen, Mark S. Litwin, Michael P. O'Leary, J. Richard Landis, J. Curtis Nickel, and Leroy M. Nyberg

Subjects
Adult, Male, Canada, medicine.medical_specialty, Urology, Pregabalin, Prostatitis, Placebo, Pelvic Pain, Article, law.invention, Hospitals, University, Double-Blind Method, Chronic prostatitis/chronic pelvic pain syndrome, Randomized controlled trial, law, Internal medicine, Internal Medicine, medicine, Humans, gamma-Aminobutyric Acid, Aged, Analgesics, Genitourinary system, business.industry, Pelvic pain, Chronic pain, Middle Aged, medicine.disease, United States, Treatment Outcome, Chronic Disease, Physical therapy, medicine.symptom, business, medicine.drug
Abstract

Background Evidence suggests that the urogenital pain of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) may be neuropathic. Methods This randomized, double-blind, placebo-controlled trial was conducted across 10 tertiary care centers in North America to determine whether pregabalin, which has been proved effective in other chronic pain syndromes, is effective in reducing CP/CPPS symptoms. In 2006-2007, 324 men with pelvic pain for at least 3 of the previous 6 months were enrolled in this study. Men were randomly assigned to receive pregabalin or placebo in a 2:1 ratio and were treated for 6 weeks. Pregabalin dosage was increased from 150 to 600 mg/d during the first 4 weeks. The primary outcome was a 6-point decrease in the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) total score. Multiple secondary outcomes were assessed. Results Of 218 men assigned to receive pregabalin, 103 (47.2%) reported at least a 6-point decrease in the NIH-CPSI total score at 6 weeks compared with 35.8% (38 of 106 men) assigned to receive placebo ( P = .07, exact Mantel-Haenszel test, adjusting for clinical sites). Compared with the placebo group, men assigned to receive pregabalin experienced reductions in the NIH-CPSI total score and subscores ( P P = .02), and improvement in total McGill Pain Questionnaire score ( P = .01). Results for the other outcomes did not differ between groups. Conclusion Pregabalin therapy for 6 weeks was not superior to placebo use in the rate of a 6-point decrease (improvement) in the NIH-CPSI total score in men with CP/CPPS. Trial Registration clinicaltrials.gov Identifier:NCT00371033

Published
2010

125. Self-stress vs manual stress in talar tilt radiography

Author

Gary, Lentell, Robert J, Desch, Susan M, Tracz, and Lisa M, Nyberg

Subjects
Adult, Male, Radiography, Analysis of Variance, Adolescent, Sprains and Strains, Humans, Female, Ankle Injuries, Stress, Mechanical, Middle Aged, Talus
Abstract

Radiographic study following inversion ankle sprain commonly is used to determine the presence of anatomic laxity across the talocrural joint.To compare the degree of talar tilt derived from a radiographic ankle stress exam under 2 conditions: self-stress vs manual stress applied by the clinician.Twenty-four subjects seeking medical care following ankle sprain underwent talar tilt stress exams of both ankles. The involved ankle was imaged with self-stress by use of a strap and with the clinician providing manual stress during the imaging exam. Mean talar tilt for the self-stress method was 2.2 degrees, compared with 5.9 degrees for the manual stress method (P.001).Significantly greater and clinically meaningful differences in talar tilt angle were found when manual stress was provided by the clinician. To avoid false negative findings of anatomic laxity in stress talar tilt studies at the ankle, a standardized procedure in which the clinician provides manual stress may be necessary.

Published
2010

126. Early termination of a trial of mycophenolate mofetil for treatment of interstitial cystitis/painful bladder syndrome: lessons learned

Author

Liyi Cen, Toby C. Chai, Karl J. Kreder, Leroy M. Nyberg, Kenneth M. Peters, Harris E. Foster, Mary P. FitzGerald, Philip M. Hanno, Robert D. Mayer, Emily S. Lukacz, J. Curtis Nickel, David Burks, Kathleen J. Propert, John W. Kusek, Claire C. Yang, J. Richard Landis, and Christopher K. Payne

Subjects
Male, medicine.medical_specialty, Randomization, Time Factors, Urology, Placebo-controlled study, Cystitis, Interstitial, Mycophenolic acid, Article, Double-Blind Method, Medicine, Humans, Urinary bladder, business.industry, Interstitial cystitis, Middle Aged, Mycophenolic Acid, medicine.disease, Interim analysis, Surgery, Clinical trial, medicine.anatomical_structure, Tolerability, Early Termination of Clinical Trials, Female, business, Immunosuppressive Agents, medicine.drug
Abstract

We evaluated the efficacy and tolerability of mycophenolate mofetil in patients with treatment refractory interstitial cystitis/painful bladder syndrome.A total of 210 patients with interstitial cystitis/painful bladder syndrome were to be randomized into a multicenter, placebo controlled trial using a 2:1 randomization. Participants in whom at least 3 interstitial cystitis/painful bladder syndrome specific treatments had failed and who had at least moderately severe symptoms were enrolled in a 12-week treatment study. The primary study end point was the global response assessment. Secondary end points were general and disease specific symptom questionnaires, and voiding diaries.Only 58 subjects were randomized before a black box warning regarding mycophenolate mofetil safety was issued by the manufacturer in October 2007. The trial was halted, and interim analysis was performed and presented to an independent data and safety monitoring board. Six of the 39 subjects (15%) randomized at study cessation were considered responders for mycophenolate mofetil compared to 3 of 19 controls (16%, p=0.67). Secondary outcome measures reflected more improvement in controls.In a randomized, placebo controlled trial that was prematurely halted mycophenolate mofetil showed efficacy similar to that of placebo to treat symptoms of refractory interstitial cystitis/painful bladder syndrome. The results of this limited study cannot be used to confirm or refute the hypothesis that immunosuppressive therapy may be beneficial to at least a subgroup of patients with interstitial cystitis/painful bladder syndrome. Despite study termination lessons can be gleaned to inform future investigations.

Published
2010

127. Acceptance of physician assistants and nurse practitioners in trauma centers

Author

Sue M, Nyberg, Kayla R, Keuter, Gina M, Berg, Amy M, Helton, and Angela D, Johnston

Subjects
Cross-Sectional Studies, Physician Assistants, Professional Role, Trauma Centers, Workforce, Humans, Nurse Practitioners, United States
Abstract

Census data published by professional organizations indicate an upward trend in the number of physician assistants (PAs) working in many specialty fields, including the subspecialty of trauma surgery. As the role of hospital-based PAs and nurse practitioners (NPs) continues to evolve, greater understanding of these roles will help identify future employment trends for these professions. The purpose of this study is to determine the prevalence of PAs and NPs in US trauma centers, to document their roles, and to identify their potential future utilization by trauma centers.A survey was mailed to 464 directors of major trauma centers in the United States. The survey was designed to evaluate trauma centers' utilization of PAs/NPs. Respondents were asked to identify specific daily tasks of PAs/NPs and to indicate potential for their future utilization.Two hundred forty-six (246) of 464 surveys were returned, for a response rate of 53%. Approximately one-third of reporting major trauma centers reported utilizing PAs/NPs. More American College of Surgeons (ACS)-verified trauma facilities utilized PAs/NPs than did nonverified facilities; and Level I trauma centers used significantly more PAs/NPs than did Level II trauma centers. Nineteen percent (19%) of respondents who did not currently utilize PAs/NPs indicated that they intended to do so in the future. The majority of facilities utilized PAs/NPs to assist with trauma resuscitation and in performing traditional tasks, including obtaining and dictating histories and physical findings, participating in rounds on the general medical floor, and dictating discharge summaries. Fewer than half of reporting facilities indicated that PAs/NPs performed more invasive procedures, such as inserting arterial lines, central lines, chest tubes, and intracranial pressure monitors.PAs and NPs are increasingly utilized as clinicians in the surgical subspecialty of trauma. In most trauma centers, PAs/NPs are utilized to complete the traditional duties of a surgical PA/NP, with fewer performing invasive procedures. Finally, 19% of responding trauma centers who do not currently utilize PAs/NPs state that they intend to in the future, indicating the potential for continued job growth for PAs/NPs in trauma care. This evaluation of the utilization of PAs/NPs in direct care to trauma patients indicates acceptance of PAs/NPs in trauma staffing models.

Published
2010

128. Hard scattering in γp interactions

Author

Alan Campbell, E. M. Hanlon, G. G. Winter, T. Ahmed, G. Grindhammer, P. Steffen, P. Baranov, M. Jaffre, J. E. Olsson, J-P. Meyer, Peter Schleper, H. P. Wellisch, W. Bartel, C. Schmidt, U. Braun, F. W. Büsser, Marc Besancon, W. Braunschweig, Stephen Maxfield, W. von Schlippe, R. Sell, A. DeRoeck, T. Merz, U. Siewert, M. Zimmer, A.S. Belousov, W. Pilgram, P. Truöl, A. Buniatian, Jean-Francois Laporte, M. Ibbotson, M. Rüffer, P. Loch, I. Tichomirov, D. Wegener, W.J. Haynes, A. B. Clegg, B. Kuznik, Emmanuel Monnier, C. A. Meyer, R. Kaschowitz, K. C. Hoeger, Andrew Mehta, D. Handschuh, H. Krehbiel, Leif J. Jönsson, H. Lohmander, S. Kasarian, Frank Raupach, S. A. Murray, T. Köhler, M. W. Krasny, S. M. Robertson, I. R. Kenyon, H. Spitzer, H. U. Martyn, V. Riech, Ph. Huet, K. Rauschnabel, N. Wulff, Armen Vartapetian, Ch. Pichler, E. Binder, J. Riedlberger, Michel Devel, G. Thompson, V. Efremenko, H. Hufnagel, P. Kasselmann, P. VanEsch, M. Hapke, G. Buschhorn, P. Fuhrmann, P. Hill, J. Bán, S. Mikocki, E. Sanchez, D. Düllmann, E. Vogel, L. Goerlich, R. C. W. Henderson, C.D. Hilton, Kerstin Borras, Vincent Hedberg, G. Knies, S. Orenstein, Nicolas Ellis, H. J. Behrend, J.C. Bizot, M. Goldberg, Martin Erdmann, W. Zimmermann, U. Obrock, J. Moreels, A. Semenov, R. Gerhards, E. Malinovski, J. Ference, H. Steiner, G. Bertrand-Coremans, F. Niebergall, V. Korbel, R. Roosen, N. Magnussen, D. Levin, J. Martyniak, M. Kuhlen, D. Lüers, G. Cozzika, F. Eisele, J.P. Phillips, R. Bernet, Stefan Valkar, L. Criegee, N. Sahlmann, A. Usik, J. Ebert, J. Haack, B. Fominykh, R. Nisius, R. Prosi, F. Brasse, R. L. Lander, Peter Robmann, H. Shooshtari, S. Egli, P. Hartz, I. O. Skillicorn, Hannes Jung, H. B. Dreis, T. R. Ebert, H. Bärwolff, E. Barrelet, S. Rusakov, J. Formánek, P. Biddulph, M. A. Jabiol, J. Zacek, S. Mani, U. Berthon, P. Staroba, A. Wegner, Vladimir Andreev, D. Gillespie, M. Danilov, Ch. Ley, P. Verrecchia, A. Fedotov, Ch. Berger, H. P. Beck, Hermann Kolanoski, D. Clarke, Eckhart Fretwurst, Günter Flügge, Stephen Burke, T. P. Yiou, J. Turnau, D. P. C. Sankey, I. F. Fensome, U. Bassler, R. J. Ellison, I. W. Walker, E. Evrard, O. Dünger, C. Trenkel, M. Steenbock, G. A. Beck, R. Hedgecock, A. Leuschner, Christoph Grab, F. Zomer, A. M. Goodall, H. Ziaeepour, J. Kurzhöfer, B. Andrieu, M. Colombo, V. Milone, Murrough Landon, V. Nagovizin, A. W. E. Dann, W.D. Dau, John A Coughlan, A. Babayev, J. Hladky, R. Eichler, I. Herynek, Horst Oberlack, G. Siegmon, B. Delcourt, A. Lebedev, L. Delbuono, Grzegorz Nowak, C. Vallée, H. K. Nguyen, I. V. Gorelov, K. Müller, M. Schulz, J. Gayler, R. Grässler, Ch. Coutures, W. Struczinski, A. E. Wright, V. Schröder, R. Felst, Richard E. Taylor, M. Eberle, J. M. Foster, C. Leverenz, J. Duboc, B. Stella, S. Eichenberger, H. Greif, F. Ould-Saada, O. Hamon, J. P. Kubenka, M. Savitsky, L. A. Womersley, P. Zavada, M. Vecko, L. Urban, R. J. Thompson, Yves Sirois, U. Gensch, M. Rietz, H. Henschel, F. Moreau, H. H. Kaufmann, J. D. Dowell, M. Rudowicz, J. Cvach, T. Kurča, J. R. Smith, R. Marshall, Dirk Krücker, S. Peters, A. Jacholkowska, R. Herma, U. Kathage, M. Gennis, D. Haidt, Dusan Bruncko, G. Franke, E. Gabathuler, F. Ferrarotto, H. Genzel, G. Lindström, C. Gruber, W. Flauger, Leith Godfrey, A. Walther, M. Nyberg, J. Harjes, P. Goritchev, A. Valkarova, Rosario Martín, K. Gamerdinger, E. Elsen, J. Marks, H. Bergstein, A. Rostovtsev, S. D. Kolya, Claus Kleinwort, Th. Naumann, H. Duhm, F. Charles, I. Sheviakov, E. Deffur, U. Krüger, J.M. Morton, P. Kostka, P. Ribarics, Y. Soloviev, M. David, V I. Shekelyan, R. Haydar, P. C. Bosetti, K. Wacker, R. Steinberg, G. Heinzelmann, U. Lenhardt, S. Levonian, M. Fleischer, S. Kermiche, J.P. Sutton, J. Bürger, A. Mavroidis, H. Küster, P. I. P. Kalmus, S. Masson, C. Zeitnitz, G. D. Patel, H. Meyer, W. Scobel, D.P. Johnson, A. Gellrich, M. Th. Wolff, T. Carli, J. V. Morris, M. Forbush, A. Schwind, L. Smolik, U. Seehausen, K. Johannsen, Christophe Royon, Y. Feng, B. Naroska, C. Pascaud, Guenter Eckerlin, R. Vick, J. Tutas, R. Langkau, H. Grässler, J. Garvey, A. M. Fomenko, N. Huot, J. Feltesse, D. Feeken, Max Klein, C. Kiesling, P. A. Smirnov, K. Meier, J. Martens, F. Kole, M. Arpagaus, K. Rybicki, J. B. Dainton, Claire Bourdarios, W. Hildesheim, K. Stephens, E. Peppel, H. T. Phillips, E. Eisenhandler, S. Willard, P. Dingus, J. Vasdik, M. Winde, L. Johnson, Steve McMahon, Tim Greenshaw, J. Heatherington, Pavel Murin, V. Brisson, D. Newton, M. Seman, G. W. Noyes, P. Lanius, V. Tchernyshov, Laurent Favart, A. Drescher, C. Dollfus, Ulrich Goerlach, E. Ryseck, M. Korn, Daniel Pitzl, G. Weber, U. Straumann, Volker Blobel, D. Schmidt, S. K. Kotelnikov, L. Hajduk, Peter Schacht, G. C. Lopez, W. Schmitz, C. Jacobson, Gregorio Bernardi, V. Boudry, J. Strachota, Jean Sacton, G. Villet, Pierre Marage, A. Courau, and P. E. Reimer

Subjects
Quantum chromodynamics, Physics, Nuclear and High Energy Physics, Particle physics, Photon, Scattering, Detector, HERA, Jet (particle physics), Spectral line, law.invention, Nuclear physics, law, High Energy Physics::Experiment, Collider
Abstract

We report on the investigation of the final state in interactions of quasi-real photons with protons. The data were taken with the H1 detector at the HERA ep collider. Evidence for hard interactions is seen in both single particle spectra and jet formation. The data can best be described by inclusion of resolved photon processess as predicted by QCD.

Published
1992

129. Increasing the time step in molecular dynamics

Author

Anna M. Nyberg and Tamar Schlick

Subjects
Chemistry, Autocorrelation, General Physics and Astronomy, Kinetic energy, Stability (probability), Boltzmann distribution, Vibration, Langevin equation, symbols.namesake, Boltzmann constant, symbols, Cutoff, Physical chemistry, Statistical physics, Physical and Theoretical Chemistry
Abstract

We examine how the two properties of the Langevin/implicit-Euler scheme for molecular dynamics (MD) - stability over large time steps and damping of high-frequency vibrations greater than some cutoff frequency ωc - affect the dynamics of liquid butane model. For time steps Δt⩽ 20 fs with a “natural” cutoff ωc=kBT/⇌h (kB and ⇌h are Boltzmann's and Planck's constants, T = temperature), the associated kinetic energy is greater than 85% of its value of Δt=1 fs, where the connection to a heat bath is weak and the generated trajectories by our scheme and conventional MD are similar. At larger Δt the connection to the heat bath is much stronger, and for Δt > 20 fs the intrinsic numerical damping of the scheme sets in. The comparison of bond-length and dihedral-angle distributions at three different time steps reveals a small, broadening trend at larger Δt. The differences in a dynamic property, the velocity autocorrelation function, are however much larger. There is a drastic difference for 2 and 20 fs, and for Δt > 40 fs most of the motion between time steps is damped and more random. Thus, while the Langevin equation per se gives a Boltzmann distribution, the expected configurational sampling can be obtained as long as the numerical damping does not disturb the balance between the random and damping terms. Consequently, for studying certain dynamic functions time steps in the same range as in conventional MD are needed, but for static properties larger time steps can be used.

Published
1992

130. Rare charm decays at HERA

Author

T. Jansen, R. Gerhards, R. Sell, W. Bartel, M. Nyberg, P. Truöl, B. Naroska, N. Sahlmann, C. Grab, R. Eichler, J. Martyniak, T. Greenshaw, S. Egli, M. Wielers, H. Jung, J. Riedlberger, J. Turnau, D. Feeken, C. Schmidt, J. Meyer, M. Rietz, F. Ould-Saada, L. Joensson, O. Overbeck, and K. Johannsen

Subjects
Physics, Nuclear physics, Nuclear and High Energy Physics, Particle physics, Luminosity (scattering theory), Meson, High Energy Physics::Phenomenology, High Energy Physics::Experiment, Monte carlo studies, Charm (quantum number), HERA, Atomic and Molecular Physics, and Optics
Abstract

The possibilities of HERA for charm production are investigated. Cross sections of up to 1μb and a design luminosity of 100pb−1 per year will allow sensitive tests on rare decays of charmed mesons and also on D0D0 mixing. Results of Monte Carlo studies are presented showing that sensitivity limits down to 10−6 are feasible.

Published
1992

131. Urological Complications of Obesity and Diabetes

Author

Firouz Daneshgari, Leroy M. Nyberg, John W. Kusek, and Jeanette S. Brown

Subjects
medicine.medical_specialty, education.field_of_study, Pediatrics, National Health and Nutrition Examination Survey, business.industry, Urology, Population, medicine.disease, Impaired fasting glucose, Obesity, Article, Surgery, Lower urinary tract symptoms, Diabetes mellitus, medicine, Urologic disease, education, business, Body mass index
Abstract

Diabetes mellitus is a spectrum of debilitating, costly diseases that can lead to multiple and serious complications as well as premature death. The United States Centers for Disease Control and Prevention estimated that in 2007, 23.6 million people or 7.8% of the population had diabetes.1 The report also indicated that 25.9% of U.S. adults 20 years old or older had impaired fasting glucose or pre-diabetes (35.4% of adults 60 years old or older). When this percentage was applied to the entire U.S. population in 2007, an estimated 57 million American adults 20 years old or older had pre-diabetes, representing a cohort likely to proceed to diabetes. At the same time, data from the most recent National Health and Nutrition Examination Survey revealed that among men and women the prevalence of obesity (body mass index 30 or greater) was 34% and is increasing in prevalence. 2 That the burden of diabetes and obesity is substantial and increasing their impact on the health of the U.S. population will become more apparent in the coming years. However, an area that has received relatively little attention is the effect of diabetes and obesity on urological complications. Diabetes and obesity impact the function and structure of the lower urinary tract including the bladder and prostate. They can lead to complications such as urinary incontinence, poor bladder emptying, sexual dysfunction, lower urinary tract symptoms and urinary tract infection. However, the prevalence of urological complications of obesity and diabetes has not been included in the Centers for Disease Control reports. Urological complications are found in up to 80% of individuals diagnosed with diabetes mellitus, a higher rate than that of widely recognized complications such as neuropathy and nephropathy.3 In March 2009, with sponsorship from the National Institute of Diabetes and Digestive and Kidney Diseases, a group of international investigators gathered to discuss and identify research priorities related to urological complications of obesity and diabetes. The articles published in this supplement to The Journal of Urology® describe major areas of current interest. To stimulate and accelerate research into urological complications, we asked the authors to provide a translational view of this clinically important area. Our primary aims were for leaders in the field to summarize current knowledge and identify new areas of research to improve our understanding of urological complications among men and women with obesity and/or diabetes. Emphasis was placed on proposing next steps to enhance our ability to prevent or effectively treat urological complications associated with diabetes and obesity. The articles in this issue are a synthesis of the presentations and new research directions, and we hope they provide the basis for future increased scientific research on urological complications among men and women with obesity and/or diabetes.

Published
2009

132. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection

Author

John G, McHutchison, Eric J, Lawitz, Mitchell L, Shiffman, Andrew J, Muir, Greg W, Galler, Jonathan, McCone, Lisa M, Nyberg, William M, Lee, Reem H, Ghalib, Eugene R, Schiff, Joseph S, Galati, Bruce R, Bacon, Mitchell N, Davis, Pabak, Mukhopadhyay, Kenneth, Koury, Stephanie, Noviello, Lisa D, Pedicone, Clifford A, Brass, Janice K, Albrecht, Mark S, Sulkowski, and A, Zaman

Subjects
Male, medicine.medical_specialty, Genotype, Alpha interferon, Hepacivirus, Interferon alpha-2, Gastroenterology, Antiviral Agents, Telaprevir, chemistry.chemical_compound, stomatognathic system, Double-Blind Method, Boceprevir, Internal medicine, Ribavirin, medicine, Humans, Dose-Response Relationship, Drug, business.industry, virus diseases, Interferon-alpha, General Medicine, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, digestive system diseases, Recombinant Proteins, Interleukin 28B, chemistry, Faldaprevir, Immunology, Peginterferon alfa-2b, RNA, Viral, Drug Therapy, Combination, Female, business, medicine.drug
Abstract

Background Treatment guidelines recommend the use of peginterferon alfa-2b or peginterferon alfa-2a in combination with ribavirin for chronic hepatitis C virus (HCV) infection. However, these regimens have not been adequately compared. Methods At 118 sites, patients who had HCV genotype 1 infection and who had not previously been treated were randomly assigned to undergo 48 weeks of treatment with one of three regimens: peginterferon alfa-2b at a standard dose of 1.5 μg per kilogram of body weight per week or a low dose of 1.0 μg per kilogram per week, plus ribavirin at a dose of 800 to 1400 mg per day, or peginterferon alfa-2a at a dose of 180 μg per week plus ribavirin at a dose of 1000 to 1200 mg per day. We compared the rate of sustained virologic response and the safety and adverse-event profiles between the peginterferon alfa-2b regimens and between the standard-dose peginterferon alfa2b regimen and the peginterferon alfa-2a regimen. Results Among 3070 patients, rates of sustained virologic response were similar among the regimens: 39.8% with standard-dose peginterferon alfa-2b, 38.0% with low-dose peginterferon alfa-2b, and 40.9% with peginterferon alfa-2a (P = 0.20 for standarddose vs. low-dose peginterferon alfa-2b; P = 0.57 for standard-dose peginterferon alfa-2b vs. peginterferon alfa-2a). Estimated differences in response rates were 1.8% (95% confidence interval [CI], −2.3 to 6.0) between standard-dose and low-dose peg interferon alfa-2b and −1.1% (95% CI, −5.3 to 3.0) between standard-dose peginterferon alfa-2b and peginterferon alfa-2a. Relapse rates were 23.5% (95% CI, 19.9 to 27.2) for standard-dose peginterferon alfa-2b, 20.0% (95% CI, 16.4 to 23.6) for lowdose peginterferon alfa-2b, and 31.5% (95% CI, 27.9 to 35.2) for peginterferon alfa2a. The safety profile was similar among the three groups; serious adverse events were observed in 8.6 to 11.7% of patients. Among the patients with undetectable HCV RNA levels at treatment weeks 4 and 12, a sustained virologic response was achieved in 86.2% and 78.7%, respectively. Conclusions In patients infected with HCV genotype 1, the rates of sustained virologic response and tolerability did not differ significantly between the two available peginterferon– ribavirin regimens or between the two doses of peginterferon alfa-2b. (ClinicalTrials. gov number, NCT00081770.)

Published
2009

133. Risk Factors for Urinary Incontinence Among Women with Type 1 Diabetes: Findings from the Epidemiology of Diabetes Interventions and Complications Study

Author

Eric Vittinghoff, John W. Kusek, Leroy M. Nyberg, Patricia A. Cleary, Patricia Gatcomb, Alka M. Kanaya, Jeanette S. Brown, Brandy N. Rutledge, and Aruna V. Sarma

Subjects
Adult, medicine.medical_specialty, Stress incontinence, Time Factors, Urology, Urinary system, Urinary incontinence, Article, Sex Factors, Risk Factors, Internal medicine, Humans, Medicine, Risk factor, Type 1 diabetes, business.industry, Odds ratio, medicine.disease, Confidence interval, Surgery, Diabetes Mellitus, Type 1, Urinary Incontinence, Female, medicine.symptom, business, Body mass index
Abstract

Objectives To determine risk factors for, and long-term effects of, glycemic control on urinary incontinence among women with type 1 diabetes enrolled in the Epidemiology of Diabetes Interventions and Complications study. Methods The Diabetes Control and Complications Trial (1982-1993) cohort follow-up, Epidemiology of Diabetes Interventions and Complications trial, began in 1994. In 2004, the female participants (n = 550) completed a self-administered questionnaire on incontinence. Our primary outcome was weekly or greater incontinence, overall and by type. Multivariate regression models were used to determine independent predictors of weekly urinary incontinence, both overall and by type. Results Overall, 38% of women reported any incontinence and 17% reported weekly or greater incontinence. An increasing body mass index (odds ratio 1.1, 95% confidence interval 1.1-1.2) was significantly associated with weekly incontinence, overall and by type. Advancing age and ≥2 urinary tract infections in the previous year were associated with weekly urge incontinence (odds ratio 1.4, 95% confidence interval 1.0-2.0 per 5 years, and odds ratio 4.9, 95% confidence interval 1.8-13.5, respectively). Weaker evidence was seen for increased risk with age for overall weekly incontinence (22% per 5 years, P = .06) and stress incontinence (21% per 5 years, P = .08). Conclusions Urinary incontinence is common among women with type 1 diabetes and the risk factors, including advancing age, increased weight, and previous urinary tract infection, are important. Weight reduction and the treatment of urinary tract infections might have the additional benefit of preventing incontinence or reducing its severity.

Published
2009

134. Effect of intensive glycemic control and diabetes complications on lower urinary tract symptoms in men with type 1 diabetes: Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study

Author

Stephen K, Van Den Eeden, Aruna V, Sarma, Brandy N, Rutledge, Patricia A, Cleary, John W, Kusek, Leroy M, Nyberg, Kevin T, McVary, and Hunter, Wessells

Subjects
Adult, Blood Glucose, Male, Urologic Diseases, Aging, endocrine system diseases, Urinary Bladder Diseases, Middle Aged, Urination Disorders, Cohort Studies, Diabetes Mellitus, Type 1, Surveys and Questionnaires, Humans, Hypoglycemic Agents, Insulin, Regression Analysis, Pathophysiology/Complications, Aged, Original Research
Abstract

OBJECTIVE Although diabetes is known to result in lower urinary tract symptoms (LUTS) in men, it remains unclear if glycemic control can mitigate urinary symptoms. We studied how diabetic characteristics are related to LUTS in the men who completed the urological assessment component (UroEDIC) of the Epidemiology of Diabetes Interventions and Complications (EDIC) follow-up study of the Diabetes Control and Complications Trial (DCCT) participants. RESEARCH DESIGN AND METHODS Study participants were men who completed the UroEDIC questionnaire at the year 10 DCCT/EDIC follow-up examination, which included data on genitourinary tract function and the American Urological Association Symptom Index (AUASI). Analyses were conducted to assess how treatment arm and diabetes characteristics were associated with LUTS using logistic regression. RESULTS Of the 591 men who completed the AUASI questions, nearly 20% (n = 115) had AUASI scores in the moderate to severe category for LUTS (AUASI score ≥8). No associations were observed between LUTS and treatment arm, or A1C levels at the DCCT baseline or end-of-study or at the year 10 EDIC (UroEDIC) examination. Of the diabetes complications studied, only erectile dysfunction at the UroEDIC examination was associated with LUTS. CONCLUSIONS These data from the UroEDIC cohort do not support the assumption that intensive glycemic control results in decreased lower urinary tract symptom severity in men with type 1 diabetes. This result may be due to a true lack of effect, or it may be due to other factors, for example, the relatively young age of the cohort.

Published
2009

136. A transition‐rate investigation by molecular dynamics with the Langevin/implicit‐Euler scheme

Author

Tamar Schlick and Anna M. Nyberg

Subjects
Physics, Bistability, General Physics and Astronomy, Transition rate matrix, Backward Euler method, Langevin equation, Molecular dynamics, symbols.namesake, Brownian dynamics, Euler's formula, symbols, Verlet integration, Statistical physics, Physical and Theoretical Chemistry
Abstract

We report results from molecular dynamics simulations for a bistable piecewise‐harmonic potential. A new method for molecular dynamics—the Langevin/implicit‐Euler scheme—is investigated here and compared to the common Verlet integration algorithm. The implicit scheme introduces new computational and physical features since it (1) does not restrict integration time step to a very small value, and (2) effectively damps vibrational modes ω≫ωc, where ωc is a chosen cutoff frequency. The main issue we explore in this study is how different choices of time steps and cutoff frequencies affect computed transition rates. The one‐dimensional, double‐well model offers a simple visual and computational opportunity for observing the two different damping forces introduced by the scheme—frictional and intrinsic—and for characterizing the dominating force at a given parameter combination. Another question we examine here is the choice of time step below which the Langevin/implicit‐Euler scheme produces ‘‘correct’’ trans...

Published
1991

137. Alfuzosin and symptoms of chronic prostatitis-chronic pelvic pain syndrome

Author

J Curtis, Nickel, John N, Krieger, Mary, McNaughton-Collins, Rodney U, Anderson, Michel, Pontari, Daniel A, Shoskes, Mark S, Litwin, Richard B, Alexander, Paige C, White, Richard, Berger, Robert, Nadler, Michael, O'Leary, Men Long, Liong, Scott, Zeitlin, Shannon, Chuai, J Richard, Landis, John W, Kusek, Leroy M, Nyberg, Anthony J, Schaeffer, and M, Hennenfent

Subjects
Adult, Male, medicine.medical_specialty, Prostatitis, Placebo, Pelvic Pain, Severity of Illness Index, law.invention, Young Adult, Randomized controlled trial, Chronic prostatitis/chronic pelvic pain syndrome, law, Internal medicine, Severity of illness, medicine, Humans, Treatment Failure, Young adult, Alfuzosin, Adrenergic alpha-Antagonists, Aged, business.industry, Pelvic pain, General Medicine, Middle Aged, medicine.disease, Surgery, Chronic Disease, Quinazolines, medicine.symptom, business, medicine.drug
Abstract

In men with chronic prostatitis-chronic pelvic pain syndrome, treatment with alpha-adrenergic receptor blockers early in the course of the disorder has been reported to be effective in some, but not all, relatively small randomized trials.We conducted a multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of alfuzosin, an alpha-adrenergic receptor blocker, in reducing symptoms in men with chronic prostatitis-chronic pelvic pain syndrome. Participation in the study required diagnosis of the condition within the preceding 2 years and no previous treatment with an alpha-adrenergic receptor blocker. Men were randomly assigned to treatment for 12 weeks with either 10 mg of alfuzosin per day or placebo. The primary outcome was a reduction of at least 4 points (from baseline to 12 weeks) in the score on the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) (range, 0 to 43; higher scores indicate more severe symptoms). A 4-point decrease is the minimal clinically significant difference in the score.A total of 272 eligible participants underwent randomization, and in both study groups, 49.3% of participants had a decrease of at least 4 points in their total NIH-CPSI score (rate difference associated with alfuzosin, 0.1%; 95% confidence interval, -11.2 to 11.0; P=0.99). In addition, a global response assessment showed similar response rates at 12 weeks: 33.6% in the placebo group and 34.8% in the alfuzosin group (P=0.90). The rates of adverse events in the two groups were also similar.Our findings do not support the use of alfuzosin to reduce the symptoms of chronic prostatitis-chronic pelvic pain syndrome in men who have not received prior treatment with an alpha-blocker. (ClinicalTrials.gov number, NCT00103402.)

Published
2008

138. Results of the SISTEr Randomized Surgical Trial Comparing the Autologous Rectus Fascia Sling to the Burch Colposuspension

Author

Linda Brubaker, Kimberly J. Dandreo, Shawn A. Menefee, Philippe Zimmern, Sharon L. Tennstedt, Veronica Mallett, Wendy W. Leng, Charles W. Nager, Michael E. Albo, Holly E. Richter, Halina M. Zyczynski, Mary P. FitzGerald, Larry T. Sirls, Leroy M. Nyberg, L. Keith Lloyd, John W. Kusek, Stephen R. Kraus, Edward Varner, Ananias C. Diokno, Kimberly Kenton, Harry W. Johnson, A. Stoddard, Peggy Norton, William D. Steers, Pamela Moalli, Toby C. Chai, and Gary E. Lemack

Subjects
medicine.medical_specialty, Rectus fascia, Sling (implant), business.industry, Urology, medicine, Burch colposuspension, Sister, business, Surgery
Published
2008

139. Assessing the impact of nanomaterials on anaerobic microbial communities

Author

Leila M. Nyberg, Ronald F. Turco, and Loring Nies

Subjects
DNA, Bacterial, biology, Biosolids, Bacteria, Sewage, Methanogenesis, Environmental engineering, General Chemistry, Carbon Dioxide, biology.organism_classification, Archaea, Nanostructures, Microbial population biology, Environmental chemistry, Environmental Chemistry, Sewage treatment, Anaerobiosis, Fullerenes, Anaerobic exercise, Methane, Temperature gradient gel electrophoresis, Sludge
Abstract

As the technological benefits of nanotechnology begin to rapidly move from laboratory to large-scale industrial application, release of nanomaterials to the environment is inevitable. Little is known about the fate and effects of nanomaterials in nature. Major environmental receptors of nanomaterials will be soil, sediment, and biosolids from wastewater treatment. Analysis of anaerobic microbial activity and communities provides needed information about the effects of nanoparticles in certain environments. In this study, biosolids from anaerobic wastewater treatment sludge were exposed to fullerene (C60) in order to model an environmentally relevant discharge scenario. Activity was assessed by monitoring production of CO2 and CH4. Changes in community structure were monitored by denaturing gradient gel electrophoresis (DGGE), using primer sets targeting the small subunit rRNA genes of Bacteria, Archaea, and Eukarya. Findings suggest that C60 fullerenes have no significant effect on the anaerobic community over an exposure period of a few months. This conclusion is based on the absence of toxicity indicated by no change in methanogenesis relative to untreated reference samples. DGGE results show no evidence of substantial community shifts due to treatment with C60, in any subset of the microbial community.

Published
2008

140. The Collapse of Time: Decennial Anniversaries and the Experience of Time in the German Democratic Republic

Author

Linda M. Nyberg

Subjects
History, media_common.quotation_subject, World War II, Socialism, Anniversaries, German Democratic Republic, Democracy, language.human_language, Newspaper, Time, German, State (polity), Law, Political Time, Economic history, language, medicine, East Germany, medicine.symptom, Soviet union, Collapse (medical), media_common
Abstract

The German Democratic Republic (GDR) collapsed in November 1989, just one month after celebrating its fortieth birthday. “Rising from the ruins” of the Second World War, East Germany—as it is more commonly known—had always boasted that socialism was the future. But by the end of 1989, German socialism was defunct. The reasons for its disintegration are often discussed, but this study proposes new explanation: the GDR collapsed as a result of the collapse of time. By studying the propaganda surrounding the four decennial anniversary celebrations, the author traces how time in the GDR became characterized by stagnation and futurelessness, a far cry from the optimism of the state’s earlier years. Analysis of newspaper articles, speeches, television specials, posters, advertisements, and an interview shed light on the temporal progression of the GDR toward its final end. Spurred by the perestroika and glasnost reforms proposed by the Soviet Union’s Mikhail Gorbachev, people in the GDR began to see a vision of a viable future, and left the extended, stagnated present behind. But the state—also knowledgeable of the deficiencies of the present—took a different approach, and retreated into the past. The present became nonexistent. And finally, the GDR collapsed in that void, a temporal implosion heralded by sledgehammers on the Berlin Wall.

Published
2008

143. Strategies for Increasing the Understanding of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Author

John W. Kusek and Leroy M. Nyberg

Subjects
medicine.medical_specialty, Mechanism (biology), business.industry, Urology, Prostatitis, medicine.disease, law.invention, Randomized controlled trial, Chronic prostatitis/chronic pelvic pain syndrome, Quality of life, law, Epidemiology, Etiology, medicine, Intensive care medicine, business, Medical costs
Abstract

During the past decade, there has been a resurgence in prostatitis research, most notably focused on chronic prostatitis/chronic pelvic pain syndrome. This work included epidemiological studies, evaluation of diagnostic tests, studies of the impact on quality of life and medical costs, pathogenic mechanisms, biomarkers, as well as randomized clinical trials. Despite this effort our understanding of this burdensome and enigmatic condition remains incomplete and management of patients challenging. The etiology of prostatitis/chronic pelvic pain syndrome is not known, risk factors have not been well described, the pathogenic mechanism(s) are obscure, and optimal treatment strategies have not yet been identified. If advances are to be made in the coming years, then the greatest payoff may come from a concerted effort to identify the cause(s) and risk factors for this condition and to develop and validate accurate phenotypes of those with the syndrome. With this knowledge, rationale selection of potential therapeutic agents may be possible to evaluate in well-designed randomized clinical trials.

Published
2008

144. On-Line Analysis Application in a Feldspar and Quartz Concentrator Plant

Author

U. Paakkinen, M. Nyberg, and I. Roitto

Subjects
Spectrum analyzer, Materials science, Mineral, Metallurgy, Mineralogy, chemistry.chemical_element, Concentrator, Feldspar, Talc, Copper, Apatite, chemistry, visual_art, visual_art.visual_art_medium, medicine, Quartz, medicine.drug
Abstract

The automation of metal concentration plants started during the latter half of the 1960’s when the first on-line X-ray fluorescence analyzers became commercially available. Nowadays over 2 00 such analyzers have been installed to measure mainly heavy metals like iron, copper, zinc, nickel, etc. The automation of mineral concentrators has remained relatively modest due to the fact that on-line analyzers capable of measuring light elements such as calcium, chlorine and kalium or even minerals such as talc or apatite have not been available. The situation is changing quickly because on-line analyzers that measure both light elements and minerals have been introduced on the market. In this presentation the Kemio feldspar and quartz plant of Lohja Oy has been selected as an example for the utilization of on-line analyzers in mineral concentrators. The quality requirements set for feldspar and quartz are examined and the utilization of an on-line X-ray fluorescence analyzer to meet these requirements is discussed. The accuracy requirements as well as the external conditions effecting the measurement are further discussed. Finally, the economic profitability of automating feldspar and quartz concentration is studied.

Published
1990

145. Prise en charge diagnostique

Author

W. Weidner, R.-U. Anderson, A.-J. Schaeffer, Leroy M. Nyberg, K. Naber, John N. Krieger, Bernard Lobel, M. Nakagawa, and Nickel Jc

Published
2007

146. Midlevel providers in a Level I trauma service: experience at Wesley Medical Center

Author

Kayla R. Keuter, Tor Wynn, William Waswick, and Sue M. Nyberg

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Cross-sectional study, Nurse practitioners, Attitude of Health Personnel, MEDLINE, Critical Care and Intensive Care Medicine, Patient satisfaction, Trauma Centers, Health care, Medicine, Humans, Nurse Practitioners, Physician assistants, Child, Hospitals, Teaching, Quality of Health Care, business.industry, Data Collection, Infant, Internship and Residency, Kansas, Middle Aged, medicine.disease, Surgery, Service experience, Cross-Sectional Studies, Physician Assistants, Patient Satisfaction, Child, Preschool, General Surgery, Workforce, Female, Medical emergency, business
Abstract

Changes in the health care system have led to reduced availability of surgical residents to function as house officers in teaching hospitals. The purpose of this cross-sectional study was to assess the level of satisfaction of patients, physicians and nurses, and ancillary providers with the care provided by the midlevel providers (MLPs) who are utilized as house officers in a Level I trauma service. This type of care model is unusual because the trauma service no longer utilizes surgical residents to provide trauma coverage.Trauma patients admitted to the hospital during a 3-month period in 2004 were surveyed, as were physicians and hospital employees who work most closely with MLPs.Patients are very satisfied (84%-86%) with the care they received from the MLPs (n = 109). There were no significant differences in satisfaction with MLPs when looking at the patient's age, gender, length of stay, or whether the patient was in the intensive care unit. Analysis of physician and hospital employee satisfaction is also strongly positive overall. Of the respondents, 84% (n = 281) agreed that MLPs have made a positive impact on the care of the trauma patient, 86% agreed that MLPs are available to address patient and staff concerns, and 80% think that MLPs have made trauma care more efficient.Trauma patients and healthcare team members of the trauma service at Wesley Medical Center, an accredited Level I trauma center, are generally satisfied with care provided by MLPs.

Published
2007

147. Burch colposuspension versus fascial sling to reduce urinary stress incontinence

Author

Ananias C. Diokno, MaryPat FitzGerald, Harry W. Johnson, Michael E. Albo, Wendy W. Leng, Peggy Norton, Gary E. Lemack, Pamela A. Moalli, Leroy M. Nyberg, Charles W. Nager, Veronica T. Mallett, Linda Brubaker, Anne M. Stoddard, Holly E. Richter, Kimberly Kenton, Toby C. Chai, L. Keith Lloyd, Philippe E. Zimmern, Shawn A. Menefee, Halina M. Zyczynski, R. Edward Varner, William D. Steers, John W. Kusek, Sharon L. Tennstedt, Larry Sirls, Kimberly J. Dandreo, and Stephen R. Kraus

Subjects
Reoperation, medicine.medical_specialty, Stress incontinence, Sling (implant), Urinary system, Urinary Incontinence, Stress, Urinary incontinence, law.invention, Patient satisfaction, Postoperative Complications, Randomized controlled trial, law, Medicine, Humans, Stress measures, Treatment Failure, business.industry, Burch colposuspension, Urinary Incontinence, Urge, General Medicine, Middle Aged, Urinary Retention, medicine.disease, Surgery, Patient Satisfaction, Urinary Tract Infections, Urologic Surgical Procedures, Female, medicine.symptom, business
Abstract

Many surgical procedures are available for women with urinary stress incontinence, yet few randomized clinical trials have been conducted to provide a basis for treatment recommendations.We performed a multicenter, randomized clinical trial comparing two procedures--the pubovaginal sling, using autologous rectus fascia, and the Burch colposuspension--among women with stress incontinence. Women were eligible for the study if they had predominant symptoms associated with the condition, a positive stress test, and urethral hypermobility. The primary outcomes were success in terms of overall urinary-incontinence measures, which required a negative pad test, no urinary incontinence (as recorded in a 3-day diary), a negative cough and Valsalva stress test, no self-reported symptoms, and no retreatment for the condition, and success in terms of measures of stress incontinence specifically, which required only the latter three criteria. We also assessed postoperative urge incontinence, voiding dysfunction, and adverse events.A total of 655 women were randomly assigned to study groups: 326 to undergo the sling procedure and 329 to undergo the Burch procedure; 520 women (79%) completed the outcome assessment. At 24 months, success rates were higher for women who underwent the sling procedure than for those who underwent the Burch procedure, for both the overall category of success (47% vs. 38%, P=0.01) and the category specific to stress incontinence (66% vs. 49%, P0.001). However, more women who underwent the sling procedure had urinary tract infections, difficulty voiding, and postoperative urge incontinence.The autologous fascial sling results in a higher rate of successful treatment of stress incontinence but also greater morbidity than the Burch colposuspension. (ClinicalTrials.gov number, NCT00064662 [ClinicalTrials.gov] .).

Published
2007

148. Analysis of a set of Australian northern brown bandicoot expressed sequence tags with comparison to the genome sequence of the South American grey short tailed opossum

Author

Sandra M. Indiviglio, Kerstin Lindblad-Toh, George H. Rosenberg, Anthony T. Papenfuss, April M Nyberg, Robert D. Miller, Michelle L. Baker, Broad Institute of MIT and Harvard, and Lindblad-Toh, Kerstin

Subjects
endocrine system, Isoodon macrourus, lcsh:QH426-470, lcsh:Biotechnology, Molecular Sequence Data, Genome, Monodelphis domestica, 03 medical and health sciences, 0302 clinical medicine, Species Specificity, lcsh:TP248.13-248.65, Genetics, Animals, 030304 developmental biology, Expressed Sequence Tags, Whole genome sequencing, 0303 health sciences, Expressed sequence tag, biology, Genome project, biology.organism_classification, Bandicoot, lcsh:Genetics, Marsupialia, GenBank, 030217 neurology & neurosurgery, Research Article, Biotechnology
Abstract

Background: Expressed sequence tags (ESTs) have been used for rapid gene discovery in a variety of organisms and provide a valuable resource for whole genome annotation. Although the genome of one marsupial, the opossum Monodelphis domestica, has now been sequenced, no EST datasets have been reported from any marsupial species. In this study we describe an EST dataset from the bandicoot, Isoodon macrourus, providing information on the transcriptional profile of the bandicoot thymus and the opportunity for a genome wide comparison between the bandicoot and opossum, two distantly related marsupial species. Results: A set of 1319 ESTs was generated from sequencing randomly chosen clones from a bandicoot thymus cDNA library. The nucleic acid and deduced amino acid sequences were compared with sequences both in GenBank and the recently completed whole genome sequence of M. domestica. This study provides information on the transcriptional profile of the bandicoot thymus with the identification of genes involved in a broad range of activities including protein metabolism (24%), transcription and/or nucleic acid metabolism (10%), metabolism/energy pathways (9%), immunity (5%), signal transduction (5%), cell growth and maintenance (3%), transport (3%), cell cycle (0.7%) and apoptosis (0.5%) and a proportion of genes whose function is unknown (5.8%). Thirty four percent of the bandicoot ESTs found no match with annotated sequences in any of the public databases. Clustering and assembly of the 1319 bandicoot ESTs resulted in a set of 949 unique sequences of which 375 were unannotated ESTs. Of these, seventy one unannotated ESTs aligned to non-coding regions in the opossum, human, or both genomes, and were identified as strong non-coding RNA candidates. Eighty-four percent of the 949 assembled ESTs aligned with the M. domestica genome sequence indicating a high level of conservation between these two distantly related marsupials. Conclusion: This study is among the first reported marsupial EST datasets with a significant inter-species genome comparison between marsupials, providing a valuable resource for transcriptional analyses in marsupials and for future annotation of marsupial whole genome sequences., National Institutes of Health (U.S.) (Grant no. IP20RR18754), National Center for Research Resources (U.S.). Institutional Development Award, National Science Foundation (U.S.) (Award MCB-0234930)

Published
2007

149. The effect of doxazosin, finasteride and combination therapy on nocturia in men with benign prostatic hyperplasia

Author

Leroy M. Nyberg, Claus G. Roehrborn, Herbert Lepor, J. Lisa Tenover, Theodore M. Johnson, Pamela K. Burrows, and John W. Kusek

Subjects
Male, medicine.medical_specialty, Combination therapy, medicine.drug_class, Urology, Prostatic Hyperplasia, Pilot Projects, urologic and male genital diseases, Placebo, Antiandrogen, chemistry.chemical_compound, Double-Blind Method, Lower urinary tract symptoms, Doxazosin, Medicine, Nocturia, Humans, Enzyme Inhibitors, Adrenergic alpha-Antagonists, Dose-Response Relationship, Drug, business.industry, Finasteride, Middle Aged, medicine.disease, Prostate-specific antigen, Urodynamics, Treatment Outcome, chemistry, Drug Therapy, Combination, medicine.symptom, business, medicine.drug, Follow-Up Studies
Abstract

We evaluated the effectiveness of single or combination drug therapy on nocturia in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia.A total of 3,047 men with lower urinary tract symptoms/benign prostatic hyperplasia enrolled in the Medical Therapy of Prostatic Symptoms trial were randomly assigned to receive doxazosin alone, finasteride alone, combination therapy or placebo. Treatment effectiveness was assessed according to intent to treat by mean reduction in self-reported nightly nocturia at 1 and 4 years. A subgroup analysis by age (younger than 70 vs 70 years old or older) was also performed.Of the men 2,583 reported 1 or more episodes of nocturia and finished 12 or more months of the trial. Mean nocturia was similar in all groups at baseline. Mean nocturia was reduced at 1 year by 0.35, 0.40, 0.54 and 0.58 in the placebo, finasteride, doxazosin and combination groups, respectively. Reductions with doxazosin and combination therapy were statistically greater than with placebo (p0.05). At 4 years nocturia was also significantly reduced in patients treated with doxazosin and combination therapy (p0.05 vs placebo). In men older than 70 years (495) all drugs significantly reduced nocturia at 1 year (finasteride 0.29, doxazosin 0.46 and combination 0.42) compared to placebo (0.11, p0.05).Doxazosin and combination therapy reduced nocturia more than placebo, but the net benefit of active drug compared to placebo was often modest with a net difference of less than 0.20 fewer nightly nocturia episodes at 1 and 4 years. Findings in men 70 years old or older were similar, with an even smaller effect observed for finasteride.

Published
2007

150. Did patients with interstitial cystitis who failed to respond to initial treatment with bacillus Calmette-Guerin or placebo in a randomized clinical trial benefit from a second course of open label bacillus Calmette-Guerin?

Author

Valerie Teal, David Burks, Robert J. Mayer, Kathleen J. Propert, Christopher K. Payne, Kenneth M. Peters, Leroy M. Nyberg, J. Curtis Nickel, Harris E. Foster, and John W. Kusek

Subjects
Nephrology, Adult, Male, medicine.medical_specialty, Randomization, Urology, Cystitis, Interstitial, Placebo, law.invention, Randomized controlled trial, Quality of life, law, Internal medicine, Diabetes mellitus, medicine, Humans, Aged, Aged, 80 and over, business.industry, Interstitial cystitis, Middle Aged, medicine.disease, Surgery, Clinical trial, Administration, Intravesical, Treatment Outcome, Retreatment, BCG Vaccine, Female, business
Abstract

We evaluated safety and efficacy outcomes in a case series of subjects who received open label intravesical bacillus Calmette-Guerin after failing to respond to bacillus Calmette-Guerin or intravesical placebo in a randomized clinical trial.Subjects who met National Institutes of Health-National Institute of Diabetes and Digestive and Kidney Diseases criteria for IC and reported at least moderate pain and frequency were initially randomized to 6 weekly intravesical instillations of bacillus Calmette-Guerin or placebo and followed for a total of 34 weeks. At 34 weeks subjects who reported that they had not responded to treatment were offered treatment with open label bacillus Calmette-Guerin, using the same course of treatment and followup. Outcomes included a patient reported global response assessment, a 24-hour voiding diary, pain, urgency, validated interstitial cystitis symptom indexes and adverse events.A total of 156 subjects elected open label bacillus Calmette-Guerin, of whom 18 (12%) withdrew during the open label series. The response rate based on the global response assessment was 18% and it was identical between those initially randomized to placebo (first course of bacillus Calmette-Guerin in the open label series) and those initially randomized to bacillus Calmette-Guerin (second course). Small improvements were observed for most secondary efficacy outcomes. Most participants reported at least 1 adverse event, primarily pain, genitourinary symptoms and gastrointestinal disturbances. However, there was no difference in adverse events between those who received the first course of bacillus Calmette-Guerin in this series compared to those who received 2 courses.The low response rate for bacillus Calmette-Guerin in this open label case series further argues against the routine use of bacillus Calmette-Guerin as treatment for interstitial cystitis.

Published
2007

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