204 results on '"Magalhaes, C"'
Search Results
102. Preliminary validation of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR) in 403 clinic patients
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Solari, N, primary, Filocamo, G, additional, Schiappapietra, B, additional, Consolaro, A, additional, Magni-Manzoni, S, additional, Viola, S, additional, Ruperto, N, additional, Saad-Magalhaes, C, additional, Tani, D, additional, Serpico, S, additional, Martini, A, additional, and Ravelli, A, additional
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- 2008
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103. A new species of the genus Kingsleya from Amazonia, with a modified key for the Brazilian Pseudothelphusidae (Crustacea: Decapoda: Brachyura)
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Magalhaes, C. and Naturalis journals & series
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Kingsleya besti spec. nov. (Brachyura: Pseudothelphusidae) ,description ,Amazon basin ,Brazil ,Taxonomy - Abstract
A new species of Pseudothelphusid crab, Kingsleya besti spec. nov., is described from Serra do Curicuriari, northwest of the State of Amazonas, Brazil. A modified dey for identification of the Pseudothelphusid crabs occurring in Brazil is given. Resumo: É descrita uma nova espécie de caranguejo da família Pseudothelphusidae, Kingsleya besti spec. nov., da Serra do Curicuriari, noroeste do Estado do Amazonas, Brasil. É fornecida uma chave de identificação modificada para as espécies de caranguejos desta família registradas para o Brasil.
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- 1990
104. Patterns of genetic variability in Brazilian Littorinids (Mollusca): a macrogeographic approach
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Andrade, S. C. S., primary, Magalhaes, C. A., additional, and Solferini, V. N., additional
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- 2003
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105. P1014: About the pathogenesis of the Romberg’s syndrome II. Experimental study and electromyographical findings in human patients
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Fernandes, T., Resende, L., Bertotti, M., and Magalhães, C.
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- 2014
- Full Text
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106. P1013: About the pathogenesis of Romberg’s syndrome I. Electromyographical findings in patients with localized scleroderma
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Fernandes, T., Resende, L., Bertotti, M., and Magalhães, C.
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- 2014
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107. Transport of oxygen and heat in leaves during photosynthesis studied photoacoustically on in vivo samples at low modulation frequencies
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Barja, P. R., primary, Cella, N., additional, Korpiun, P., additional, Magalhaes, C. N., additional, Mansanares, A. M., additional, da Silva, E. C., additional, and Vargas, H., additional
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- 1999
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108. Evaluation matrix model in the Santos mental health services
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Andreoli, S., Magalhaes, C., and Bellemo, A.
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Santos, Brazil -- Research ,Santos, Brazil -- Health policy ,Psychiatric services -- Research ,Health ,Social sciences - Published
- 2004
109. Properties of amorphous silicon-carbon alloys with very low densities of states
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Magalhaes, C Schmidt de, primary, Alvarez, F, additional, Sebastiani, M, additional, Fiorini, P, additional, Pozzili, F, additional, and Evangelisti, F, additional
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- 1993
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- View/download PDF
110. Proxy-reported health-related quality of life of patients with juvenile idiopathic arthritis: the Pediatric Rheumatology International Trials Organization multinational quality of life cohort study.
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Oliveira S, Ravelli A, Pistorio A, Castell E, Malattia C, Prieur AM, Saad-Magalhaes C, Murray KJ, Bae SC, Joos R, Foeldvari I, Duarte-Salazar C, Wulffraat N, Lahdenne P, Dolezalova P, de Inocencio J, Kanakoudi-Tsakalidou F, Hofer M, Nikishina I, and Ozdogan H
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- 2007
111. Economic instability, structural change, and the property markets: the late-1980s office boom in...
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De Magalhaes, C.
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OFFICES , *ECONOMIC development - Abstract
Focuses on the functioning of the office market in the city of Sao Paulo, Brazil in the late 1980s and early 1990s. Review of related literature; Overview of the service growth and office development in Sao Paulo; Factors that triggered the 1980s office boom.
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- 1998
112. Nos diagramas do texto, sombras da violência no 'verão' de Porto Alegre = In the diagrams of the text, shades of the violence at 'verão' in Porto Alegre
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Magalhães, Carlos Augusto
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ANÁLISE LITERÁRIA ,LITERATURA ,PORTO ALEGRE NA LITERATURA ,French literature - Italian literature - Spanish literature - Portuguese literature ,PQ1-3999 - Abstract
Este artigo visa apresentar uma leitura da violência nos contos “Verão” e “A aventura prático-intelectual do Sr. Alexandre Costa” do livro Os lados do círculo. Nessa leitura, o objetivo é observar as experiências com os espaços e seus processos de expansão em Porto Alegre, pensando-se nas décadas de 50, 60 e 70, em comparação com as experiências no século XXI. Com sua economia e ação concentrada, o conto torna-se um gênero adequado para essas e outras leituras, conforme alguns comentários do autor das narrativas em estudo. Ambos os contos analisam a violência urbana: o homicídio de pessoas moradoras de rua por um serial killer em “A aventura. . . ” e do empresário Wagner Henrique, resultado de embates entre ele e a população da favela da Vila Cruzeiro no conto “Verão”
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- 2015
113. Estudo comparativo entre contextos de brincadeiras em instituição de acolhimento infantil = Comparative study of contexts of play in the host institution for children = Estudio de comparación entre contextos de juegos en institución de acogida infantil
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Oliveira, Luísa Sousa Monteiro, Reis, Daniela Castro dos, Magalhães, Celina Maria Colino, and Pedroso, Janari da Silva
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psicologia ,crianças - assistência social ,brincadeiras ,Psychology ,BF1-990 - Abstract
O objetivo deste trabalho foi descrever e comparar as brincadeiras ocorridas em contextos: estruturado (CE) e semiestruturado (CSE) em uma instituição de acolhimento infantil. Participaram 10 crianças de cinco a seis anos, com tempo de acolhimento que variou de um a 12 meses. As sessões observacionais foram realizadas no CE (brinquedoteca) e no CSE (barracão, playground e piscina). Realizaram-se 117 registros de cinco minutos, totalizando 585 minutos de observação. Os resultados mostraram que a categoria brincadeira simbólica foi a mais frequente (43,25%), seguida da contingência física (35,04%) e da brincadeira exploratória (8,38%). A escolha da brincadeira variou em função do contexto. A estereotipia de gênero foi observada na escolha dos temas das brincadeiras. O estudo elucida para a oferta de contextos de brincadeira diferenciados, disponibilidade de recursos lúdicos e humanos sensíveis às inúmeras demandas das crianças, de modo que as instituições de acolhimento infantil configurem-se como contextos abrangentes de desenvolvimento
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- 2015
114. Transport of oxygen and heat in leaves during photosynthesis studied photoacoustically on in vivo samples at low modulation frequencies.
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Barja, P. R., Cella, N., Korpiun, P., Magalhaes, C. N., Mansanares, A. M., da Silva, E. C., and Vargas, H.
- Published
- 1999
- Full Text
- View/download PDF
115. Análise comparativa do perfil de crianças em acolhimento institucional nos anos de 2004 e 2009 = Comparative analysis of the profile of children in institutional care the years of 2004 and 2009 = Análisis comparativo del perfil de los niños internados en instituciones en los años de 2004 y 2009
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Cavalcante, Lília Iêda Chaves, Magalhães, Celina Maria Colino, and Reis, Daniela Castro dos
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psicologia ,crianças ,institucionalização ,desenvolvimento infantil ,vulnerabilidade social ,Psychology ,BF1-990 - Abstract
O estudo apresenta uma análise comparativa dos aspectos que caracterizaram a população infantil atendida em uma instituição de acolhimento na Região Metropolitana de Belém-Pará, nos anos de 2004 (n = 287) e 2009 (n = 249). Foram comparadas variáveis referentes às características sociodemográficas das crianças, ao motivo do acolhimento, a idade à entrada na instituição e o tempo de permanência. Os resultados mostram que o perfil da população atendida sofreu alterações importantes: em cinco anos, aumentou a idade em que as crianças ingressaram na instituição, o que pode evitar ou atenuar as sequelas geradas pela privação do cuidado parental, porém também estendeu o tempo que elas se mantiveram atendidas pelo serviço, sendo este um aspecto que agrava a sua condição de vulnerabilidade. Estes dados corroboram o argumento de que é necessário acompanhar ao longo do tempo estas e outras características dessa população infantil, para adequar a gestão dos serviços de acolhimento às suas demandas desenvolvimentais
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- 2014
116. Valores humanos e significado do dinheiro: um estudo correlacional = Human values and meaning of money: a correlational study = Los valores humanos y el significado del dinero: un estudio correlacional
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Lauer-Leite, Iani Dias, Magalhães, Celina Maria Colino, Gouveia, Rildésia Silva Veloso, and Fonsêca, Patrícia Nunes da
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psicologia aplicada ,dinheiro - aspectos psicológicos ,valor (psicologia) ,Psychology ,BF1-990 - Abstract
Este estudo teve por objetivo verificar a relação entre os valores humanos e o significado do dinheiro para crianças. Participaram 1. 445 estudantes com idade média de 11 anos (dp = 1,09), a maioria do sexo masculino (51%), distribuídos entre as regiões Norte (n = 585) e Nordeste (n = 860) do Brasil. Estes responderam a Escala de Significado do Dinheiro para Crianças (ESDC), Questionário de Valores Básicos Infantis (QVBI) e questões demográficas. Os resultados indicaram diferenças com relação à variável sexo e a região de moradia. Assim como, correlação entre o fator felicidade e a subfunção realização (r = 0,28); os fatores solidão e altruísmo com a subfunção suprapessoal (r = 0,13 e 0,26, respectivamente); e, por fim, o fator exclusão com a subfunção normativa (r = -0,08). Conclui-se que os valores humanos infantis, o sexo e o contexto regional influenciam no significado do dinheiro
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- 2014
117. Cenas urbanas de mobilidade e de desterritorialização nas canções de O Rappa = Urban scenes of mobility and geographical displacement in the songs by 'O Rappa'
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Magalhães, Carlos Augusto
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LITERATURA E MÚSICA ,FAVELAS - RIO DE JANEIRO ,French literature - Italian literature - Spanish literature - Portuguese literature ,PQ1-3999 - Abstract
As vivências e as experiências com o tempo e com o espaço são invocadas também para a caracterização da contemporaneidade urbana. Atualmente, a complexidade da vida nas cidades aponta para a inconveniência de abordagens polarizadas e dualistas. Há uma tendência de qualificação de agendas que se desenham e se nomeiam valendo-se da ambiguidade e da pluralidade expressional. Essas reflexões podem abrir rotas de compreensão para se lidar com a concomitância de aspectos antagônicos da cidade do Rio de Janeiro. Em relação à favela, observa-se que as condições de vida variaram muito ao longo da própria história e seu potencial de alteridade se manteve sempre alto. Imagens ambíguas do Rio de Janeiro são mostradas nas canções do grupo O Rappa, no seu último álbum, Sete Vezes, especialmente nas composições Meu mundo é o barro e Monstro invisível
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- 2013
118. Pelourinho e Tabuão – cenas e cenários = Pelourinho and Tabuão – scenes and sceneries
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Magalhães, Carlos Augusto
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literatura brasileira - história e crítica ,Philology. Linguistics ,P1-1091 ,Literature (General) ,PN1-6790 - Abstract
Os conceitos de lugar e não-lugar (Marc Augé) constituem um dos operadores de leitura dos dois textos contemporâneos que se debruçam sobre o centro velho de Salvador, especialmente o Pelourinho e o Tabuão. O primeiro fragmento da corrente de internet Salvador, para aprender e se divertir, divulgado após o carnaval de 2011. O segundo o conto O visitante invisível de Carlos Ribeiro. Com humor, a corrente aponta o esvaziamento da região central e seu distanciamento da vida cotidiana. Configura-se o não-lugar. A narrativa empreende trânsitos também através da geografia do centro velho, mas o itinerário eleito adota uma perspectiva bastante singular, uma vez que se desenham significativas interligações com experiências existenciais do passado. O instante flagrado tece uma temporalidade subjetiva, articulada com um tempo de experiências emocionais. Estabelece-se o lugar
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- 2011
119. Day surgery - Emphases from IAAS training workshop on ambulatory surgery,Jedn Odnevna Kirurgija - Naglascimedunarodnog IAAS tečaja ambulantne kirurgije
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Antabak, A., Paulo Lemos, and Magalhaes, C.
120. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
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Author et al, Bateman, R. M., Sharpe, M. D., Jagger, J. E., Ellis, C. G., Solé-Violán, J., López-Rodríguez, M., Herrera-Ramos, E., Ruíz-Hernández, J., Borderías, L., Horcajada, J., González-Quevedo, N., Rajas, O., Briones, M., Rodríguez de Castro, F., Rodríguez Gallego, C., Esen, F., Orhun, G., Ergin Ozcan, P., Senturk, E., Ugur Yilmaz, C., Orhan, N., Arican, N., Kaya, M., Kucukerden, M., Giris, M., Akcan, U., Bilgic Gazioglu, S., Tuzun, E., Riff, R., Naamani, O., Douvdevani, A., Takegawa, R., Yoshida, H., Hirose, T., Yamamoto, N., Hagiya, H., Ojima, M., Akeda, Y., Tasaki, O., Tomono, K., Shimazu, T., Ono, S., Kubo, T., Suda, S., Ueno, T., Ikeda, T., Ogura, H., Takahashi, H., Kang, J., Nakamura, Y., Kojima, T., Izutani, Y., Taniguchi, T., O, M., Dinter, C., Lotz, J., Eilers, B., Wissmann, C., Lott, R., Meili, M. M., Schuetz, P. S., Hawa, H., Sharshir, M., Aburageila, M., Salahuddin, N., Chantziara, V., Georgiou, S., Tsimogianni, A., Alexandropoulos, P., Vassi, A., Lagiou, F., Valta, M., Micha, G., Chinou, E., Michaloudis, G., Kodaira, A., Imaizumi, H., De la Torre-Prados, M. V., Garcia-De la Torre, A., Enguix-Armada, A., Puerto-Morlan, A., Perez-Valero, V., Garcia-Alcantara, A., Bolton, N., Dudziak, J., Bonney, S., Tridente, A., Nee, P., Nicolaes, G., Wiewel, M., Schultz, M., Wildhagen, K., Horn, J., Schrijver, R., Van der Poll, T., Reutelingsperger, C., Pillai, S., Davies, G., Mills, G., Aubrey, R., Morris, K., Williams, P., Evans, P., Gayat, E. G., Struck, J., Cariou, A., Deye, N., Guidet, B., Jabert, S., Launay, J., Legrand, M., Léone, M., Resche-Rigon, M., Vicaut, E., Vieillard-Baron, A., Mebazaa, A., Arnold, R., Capan, M., Linder, A., Akesson, P., Popescu, M., Tomescu, D., Sprung, C. L., Calderon Morales, R., Munteanu, G., Orenbuch-Harroch, E., Levin, P., Kasdan, H., Reiter, A., Volker, T., Himmel, Y., Cohen, Y., Meissonnier, J., Girard, L., Rebeaud, F., Herrmann, I., Delwarde, B., Peronnet, E., Cerrato, E., Venet, F., Lepape, A., Rimmelé, T., Monneret, G., Textoris, J., Beloborodova, N., Moroz, V., Osipov, A., Bedova, A., Sarshor, Y., Pautova, A., Sergeev, A., Chernevskaya, E., Odermatt, J., Bolliger, R., Hersberger, L., Ottiger, M., Christ-Crain, M., Mueller, B., Schuetz, P., Sharma, N. K., Tashima, A. K., Brunialti, M. K., Machado, F. R., Assuncao, M., Rigato, O., Salomao, R., Cajander, S. C., Rasmussen, G., Tina, E., Söderquist, B., Källman, J., Strålin, K., Lange, A. L., Sundén-Cullberg, J. S., Magnuson, A. M., Hultgren, O. H., Van der Geest, P., Mohseni, M., Linssen, J., De Jonge, R., Duran, S., Groeneveld, J., Miller, R., Lopansri, B. K., McHugh, L. C., Seldon, A., Burke, J. P., Johnston, J., Reece-Anthony, R., Bond, A., Molokhia, A., Mcgrath, C., Nsutebu, E., Bank Pedersen, P., Pilsgaard Henriksen, D., Mikkelsen, S., Touborg Lassen, A., Tincu, R., Cobilinschi, C., Ghiorghiu, Z., Macovei, R., Wiewel, M. A., Harmon, M. B., Van Vught, L. A., Scicluna, B. P., Hoogendijk, A. J., Zwinderman, A. H., Cremer, O. L., Bonten, M. J., Schultz, M. J., Juffermans, N. P., Wiersinga, W. J., Eren, G., Tekdos, Y., Dogan, M., Acicbe, O., Kaya, E., Hergunsel, O., Alsolamy, S., Ghamdi, G., Alswaidan, L., Alharbi, S., Alenezi, F., Arabi, Y., Heaton, J., Boyce, A., Nolan, L., Dukoff-Gordon, A., Dean, A., Mann Ben Yehudah, T., Fleischmann, C., Thomas-Rueddel, D., Haas, C., Dennler, U., Reinhart, K., Suntornlohanakul, O., Khwannimit, B., Breckenridge, F., Puxty, A., Szturz, P., Folwarzcny, P., Svancara, J., Kula, R., Sevcik, P., Caneva, L., Casazza, A., Bellazzi, E., Marra, S., Pagani, L., Vetere, M., Vanzino, R., Ciprandi, D., Preda, R., Boschi, R., Carnevale, L., Lopez, V., Aguilar Arzapalo, M., Barradas, L., Escalante, A., Gongora, J., Cetina, M., Adamik, B, Jakubczyk, D, Kübler, A, Radford, A., Lee, T., Singer, J., Boyd, J., Fineberg, D., Williams, M., Russell, J., Scarlatescu, E., Droc, G., Arama, S., Müller, M., Straat, M., Zeerleder, S. S., Fuchs, C. F., Scheer, C. S., Wauschkuhn, S. W., Vollmer, M. V., Meissner, K. M., Kuhn, S. K., Hahnenkamp, K. H., Rehberg, S. R., Gründling, M. G., Hamaguchi, S., Gómez-Sánchez, E., Heredia-Rodríguez, M., Álvarez-Fuente, E., Lorenzo-López, M., Gómez-Pesquera, E., Aragón-Camino, M., Liu-Zhu, P., Sánchez-López, A., Hernández-Lozano, A., Peláez-Jareño, M. T., Tamayo, E., Thomas-Rüddel, D. O., Adora, V., Kar, A., Chakraborty, A., Roy, S., Bandyopadhyay, A., Das, M., BenYehudah, G., Salim, M., Kumar, N., Arabi, L., Burger, T., Lephart, P., Toth-martin, E., Valencia, C., Hammami, N., Blot, S., Vincent, J. L., Lambert, M. L., Brunke, J., Riemann, T., Roschke, I., Nimitvilai, S., Jintanapramote, K., Jarupongprapa, S., Adukauskiene, D., Valanciene, D., Bose, G., Lostarakos, V., Carr, B., Khedher, S., Maaoui, A., Ezzamouri, A., Salem, M., Chen, J., Cranendonk, D. R., Day, M., Penrice, G., Roy, K., Robertson, P., Godbole, G., Jones, B., Booth, M., Donaldson, L., Kawano, Y., Ishikura, H., Al-Dorzi, H., Almutairi, M., Alhamadi, B., Crizaldo Toledo, A., Khan, R., Al Raiy, B., Talaie, H., Van Oers, J. A., Harts, A., Nieuwkoop, E., Vos, P., Boussarsar, Y., Boutouta, F., Kamoun, S., Mezghani, I., Koubaji, S., Ben Souissi, A., Riahi, A., Mebazaa, M. S., Giamarellos-Bourboulis, E., Tziolos, N., Routsi, C., Katsenos, C., Tsangaris, I., Pneumatikos, I., Vlachogiannis, G., Theodorou, V., Prekates, A., Antypa, E., Koulouras, V., Kapravelos, N., Gogos, C., Antoniadou, E., Mandragos, K., Armaganidis, A., Robles Caballero, A. R., Civantos, B., Figueira, J. C., López, J., Silva-Pinto, A., Ceia, F., Sarmento, A., Santos, L., Almekhlafi, G., Sakr, Y., Baharoon, S., Aldawood, A., Matroud, A., Alchin, J., Al Johani, S., Balkhy, H., Yousif, S. Y., Alotabi, B. O., Alsaawi, A. S., Ang, J., Curran, M. D., Enoch, D., Navapurkar, V., Morris, A., Sharvill, R., Astin, J., Patel, J., Kruger, C., O’Neal, J., Rhodes, H., Jancik, J., François, B., Laterre, P. F., Eggimann, P., Torres, A., Sánchez, M., Dequin, P. F., Bassi, G. L., Chastre, J., Jafri, H. S., Ben Romdhane, M., Douira, Z., Bousselmi, M., Vakalos, A., Avramidis, V., Craven, T. H., Wojcik, G., Kefala, K., McCoubrey, J., Reilly, J., Paterson, R., Inverarity, D., Laurenson, I., Walsh, T. S., Mongodi, S., Bouhemad, B., Orlando, A., Stella, A., Via, G., Iotti, G., Braschi, A., Mojoli, F., Haliloglu, M., Bilgili, B., Kasapoglu, U., Sayan, I., Süzer Aslan, M., Yalcin, A., Cinel, I., Ellis, H. E., Bauchmuller, K., Miller, D., Temple, A., Luyt, C. E., Singer, M., Nassar, Y., Ayad, M. S., Trifi, A., Abdellatif, S., Daly, F., Nasri, R., Ben Lakhal, S., Gul, F., Kuzovlev, A., Shabanov, A., Polovnikov, S., Kadrichu, N., Dang, T., Corkery, K., Challoner, P., Bassi, G. Li, Aguilera, E., Chiurazzi, C., Travierso, C., Motos, A., Fernandez, L., Amaro, R., Senussi, T., Idone, F., Bobi, J., Rigol, M., Hodiamont, C. J., Janssen, J. M., Bouman, C. S., Mathôt, R. A., De Jong, M. D., Van Hest, R. M., Payne, L., Fraser, G. L., Tudor, B., Lahner, M., Roth, G., Krenn, C., Jault, P., Gabard, J., Leclerc, T., Jennes, S., Que, Y., Rousseau, A., Ravat, F., Eissa, A., Al-Harbi, S., Aldabbagh, T., Abdellatif., S., Paramba, F., Purayil, N., Naushad, V., Mohammad, O., Negi, V., Chandra, P., Kleinsasser, A., Witrz, M. R., Buchner-Doeven, J. F., Tuip-de Boer, A. M., Goslings, J. C., Van Hezel, M., Boing, A, Van Bruggen, R, Juffermans, N, Markopoulou, D., Venetsanou, K., Kaldis, V., Koutete, D., Chroni, D., Alamanos, I., Koch, L., Walter, E., Maekawa, K., Hayakawa, M., Kushimoto, S., Shiraishi, A., Kato, H., Sasaki, J., Matauoka, T., Uejima, T., Morimura, N., Hagiwara, A., Takeda, M., Tarabrin, O., Shcherbakow, S., Gavrychenko, D., Mazurenko, G., Ivanova, V., Chystikov, O., Plourde, C., Lessard, J., Chauny, J., Daoust, R., Kropman, L., In het Panhuis, L., Konings, J., Huskens, D., Schurgers, E., Roest, M., De Laat, B., Lance, M., Durila, M., Lukas, P., Astraverkhava, M., Jonas, J., Budnik, I., Shenkman, B., Hayami, H., Koide, Y., Goto, T., Iqbal, R., Alhamdi, Y., Venugopal, N., Abrams, S., Downey, C., Toh, C. H., Welters, I. D., Bombay, V. B., Chauny, J. M., Daoust, R. D., Lessard, J. L., Marquis, M. M., Paquet, J. P., Siemens, K., Sangaran, D., Hunt, B. J., Durward, A., Nyman, A., Murdoch, I. A., Tibby, S. M., Ampatzidou, F., Moisidou, D., Dalampini, E., Nastou, M., Vasilarou, E., Kalaizi, V., Chatzikostenoglou, H., Drossos, G., Spadaro, S., Fogagnolo, A., Fiore, T., Schiavi, A., Fontana, V., Taccone, F., Volta, C., Chochliourou, E., Volakli, E., Violaki, A., Samkinidou, E., Evlavis, G., Panagiotidou, V., Sdougka, M., Mothukuri, R., Battle, C., Guy, K., Wijesuriya, J., Keogh, S., Docherty, A., O’Donnell, R., Brunskill, S., Trivella, M., Doree, C., Holst, L., Parker, M., Gregersen, M., Almeida, J., Walsh, T., Stanworth, S., Moravcova, S., Mansell, J., Rogers, A., Smith, R. A., Hamilton-Davies, C., Omar, A., Allam, M., Bilala, O., Kindawi, A., Ewila, H., Malamas, A., Ferreira, G., Caldas, J., Fukushima, J., Osawa, E. A., Arita, E., Camara, L., Zeferino, S., Jardim, J., Gaioto, F., Dallan, L., Jatene, F. B., Kalil Filho, R., Galas, F., Hajjar, L. 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E., Güiza, F., Janssens, T., Hermans, G., Vanhorebeek, I., De Bock, K., Van den Berghe, G., Langouche, L., Miles, B., Madden, S., Weiler, M., Marques, P., Rodrigues, C., Boeira, M., Brenner, K., Leães, C., Machado, A., Townsend, R., Andrade, J., Kishore, R., Fenlon, C., Fiks, T., Ruijter, A., Te Raa, M., Spronk, P., Docherty, P., Dickson, J., Moltchanova, E., Scarrot, C., Hall, T., Ngu, W. C., Jack, J. M., Pavli, A., Gee, X., Akin Korhan, E., Shirazy, M., Fayed, A., Gupta, S., Kaushal, A., Dewan, S., Varma, A., Ghosh, E., Yang, L., Eshelman, L., Lord, B., Carlson, E., Broderick, R., Ramos, J., Forte, D., Yang, F., Feeney, J., Wilkinson, K., Shuker, K., Faulds, M., Bryden, D., England, L., Shuker, K, Tridente, A, Faulds, M, Matheson, A, Gaynor, J., Bryden, D, ᅟ, S South Yorkshire Hospitals Research Collaboration, Peroni, B., Daglius-Dias, R., Miranda, L., Cohen, C., Carvalho, C., Velasco, I., Kelly, J. M., Neill, A., Rubenfeld, G., Masson, N., Min, A., Boezeman, E., Hofhuis, J., Hovingh, A., De Vries, R., Cabral-Campello, G., Van Mol, M., Nijkamp, M., Kompanje, E., Ostrowski, P., Kiss, K., Köves, B., Csernus, V., Molnár, Z., Hoydonckx, Y., Vanwing, S., Medo, V., Galvez, R., Miranda, J. P., Stone, C., Wigmore, T., Arunan, Y., Wheeler, A., Wong, Y., Poi, C., Gu, C., Molmy, P., Van Grunderbeeck, N., Nigeon, O., Lemyze, M., Thevenin, D., Mallat, J., Correa, M., Carvalho, R. T., Fernandez, A., McBride, C., Koonthalloor, E., Walsh, C., Webber, A., Ashe, M., Smith, K., Volakli, E. A., Dimitriadou, M., Mantzafleri, P., Vrani, O., Arbouti, A., Varsami, T., Bollen, J. A., Van Smaalen, T. C., De Jongh, W. C., Ten Hoopen, M. M., Ysebaert, D., Van Heurn, L. W., Van Mook, W. N., Roze des Ordons, A., Couillard, P., Doig, C., Van Keer, R. V., Deschepper, R. D., Francke, A. F., Huyghens, L. H., Bilsen, J. B., Nyamaizi, B., Dalrymple, C., Dobru, A., Marrinan, E., Ankuli, A., Struthers, R., Crawford, R., Mactavish, P., Morelli, P., Degiovanangelo, M., Lemos, F., MArtinez, V., Cabrera, J., Rutten, A., Van Ieperen, S., De Geer, S., Van Vugt, M., Der Kinderen, E., Giannini, A., Miccinesi, G, Marchesi, T, and Prandi, E
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health care facilities, manpower, and services ,education ,Erratum ,Critical Care and Intensive Care Medicine ,reproductive and urinary physiology ,humanities ,health care economics and organizations - Full Text
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121. A Brazilian registry of juvenile dermatomyositis: Onset features and classification of 189 cases
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Sato, J. O., Sallum, A. M. E., Ferriani, V. P. L., Marini, R., Sacchetti, S. B., Okuda, E. M., Carvalho, J. F., Pereira, R. M. R., Len, C. A., Terreri, M. T., Lotufo, S. A., Romanelli, P. R., Ramos, V. C. S., Hilario, M. O., Silva, C. A., Corrente, J. E., and Saad-Magalhaes, C.
122. Pediatric antiphospholipid syndrome: clinical and immunologic features of 121 patients in an international registry.
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Avcin T, Cimaz R, Silverman ED, Cervera R, Gattorno M, Garay S, Berkun Y, Sztajnbok FR, Silva CA, Campos LM, Saad-Magalhaes C, Rigante D, Ravelli A, Martini A, Rozman B, and Meroni PL
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- 2008
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123. INSUFFICIENT BIRTH WEIGHT: STUDY OF ASSOCIATED FACTORS IN two COHORTS OF NEWBORN INFANTS FROM RIBEIRAO PRETO, BRAZIL, SEPARATED BY A 15-YEAR INTERVAL.
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Andreoli, S., Magalhaes, C., Bellemo, A., Filho, A., Araujo, S., Pinho, R., Pinto, R., and Martin, D.
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LOW birth weight , *NEWBORN infants , *PUBLIC health research ,NEWBORN infant health ,DEVELOPING countries - Abstract
In many developed countries, insufficient birth weight (IBW) has been decreasing, but in developing countries these rates continue to be high and very few studies have assessed the factors associated with IBW infants and their long term consequences. The main objective is to investigate the possible factors associated with IBW in two cohorts of singleton newborn infants in one of the cities of Brazil, the first study in 1978-1979 and the second in 1994 and to identity the causes of the increase in IBW that occurred during this period.
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- 2004
124. Photoluminescence studies on silicon carbon alloys
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Schmidt de Magalhães, C., Bittencourt, C., Tessler, L.R., and Alvarez, F.
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- 1993
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125. Study compares methods that measure hydrogen use in diesel hydrotreaters.
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Lee, C. K., McGovern, Steve, da Silva, Luiz E. Magalhaes C., and Osowski, Carlos A.
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HYDROGEN ,CONSUMPTION (Economics) ,ANALYTICAL chemistry ,GAS analysis ,PILOT plants - Abstract
The article reports that more accurate methods for analyzing hydrogen consumption are the feed-total liquid product (TLP) H-content analysis and chemical analysis methods, according to a study. The authors note that accuracy of result is better using the mentioned methods than using gas analyses alone. All of the methods must be used due to variability in the various methods used to determine chemical hydrogen consumption in pilot-plant testing.
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- 2008
126. Tangible places for intangible products : the role of space in the creative digital economy, Tech City, London
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Borowczyk Martins, J., De Magalhaes, C., and Stevens, Q.
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710 - Abstract
This thesis explores the relationship between space and creative digital production in Shoreditch, East London (2009-2014). It seeks to identify the spatial conditions that, at multiple scales, mediate and support the operation of digital industries in inner-city locations. Drawing on 'productionist' approaches, which examine creative industries as an industry, work is conceptualized as six activities (producing, meeting, networking, learning, displaying, socializing) performed across four spatial settings: the extended workplace, workspaces, industry events, and the neighbourhood. This qualitative case study uses three data collection methods: semi-structured interviews with workers and industry actors, observations of selected settings, and secondary data. The area is an emergent cluster of digital firms known as 'Silicon Roundabout' and 'Tech City', providing a less explored but relevant case. The thesis' contribution is threefold. First, it provides an empirical account of the spatiality of digital work in Shoreditch. This reveals a network of spaces used for work (base, ancillary, and events) suggesting a reconfiguration, and extension, of the 'workplace' in these industries. This spatial extension is limited and associated with spatial requirements of the tasks involved; the office still plays a central role in digital production. Second, the study identifies macro and micro spatial conditions that mediate and support these work patterns across the four spatial settings and advances the conceptualization of functional, social, and symbolic aspects of these relationships, expanding the understanding of why and how place matters in the digital economy. Third, the analysis reveals that 'structured interaction' and micro processes of spatial segregation and exclusion are critical to support a range of work and social practices in digital production. In contrast to influential accounts that associate creative cities with diversity and tolerance, at the scale of these spatial practices, processes of selection and quest for sameness underpin the operation of these industries within urban space(s).
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- 2016
127. Piecemeal versus comprehensive redevelopment in deteriorated neighbourhoods of Tehran
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Soltani Azad, K. and De Magalhaes, C.
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710 - Abstract
Tehran, the capital of Iran, on the one hand faces extensive deterioration in its inner-city neighbourhoods and on the other hand, faces rapid population growth. The government has adapted urban regeneration as a policy that not only accommodates this growth within the city boundaries, but also tackles the deterioration problems. In this respect, this research compares two urban regeneration models, namely piecemeal and comprehensive redevelopments. In doing so it tries to understand how these two redevelopment models operate in deteriorated neighbourhoods of Tehran. This question is addressed by analysing the implementation and property development aspects of each redevelopment, with a specific focus on developers’ behaviour regarding these two models. At the theoretical level this research compares direct versus indirect planning in urban regeneration interventions from an institutional perspective. This derives from the work of Webster and Lai (2003) where they examined spontaneous planning versus centralised planning and Carmona (2009) where he analysed different modes of planning that on the one hand ranges from plan-based to opportunity-based, and on the other hand, from state-led to market-led modes of planning. Further, by building on the institutional perspective offered by Healy and Barret (1990) and Guy and Henneberry (2000) this thesis utilises the structure and agency approach to unravel the behaviour of property actors. Two neighbourhoods that have undergone redevelopments in Tehran, one piecemeal and one comprehensive, are chosen as case studies. As such, this research is an empirical account of two developments, utilising institutional analysis as a qualitative methodological approach in unravelling the ways in which property actors see the development process and their subsequent actions. Semi-structured interviews with property actors are a critical part of data collection, alongside documents and local and national census, and direct observations. The thesis improves our understanding of the process of built environment production, and the role of the state in the development process. It has demonstrated that the development decision-making cannot be solely understood as the result of economic rationality, as it occurs within institutional contexts structured by dynamic needs and concerns of actors. In advancing institutional analysis, this thesis by focusing on two specific projects, demonstrates the different approaches taken by property developers, development organisations and planners as they engaged differently with the wider structures set by the government through different policies.
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- 2014
128. Planning for public realm conservation : the case of Portugal's World Heritage Cities
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Cidre, E. M. P., Carmona, M., and de Magalhaes, C.
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363.6 - Abstract
This research aims to understand the relation between urban conservation planning and urban design with particular reference to the public spaces of ‘World Heritage' Cities (WHC) in Portugal. It is concerned with investigating the effectiveness of national conservation policies in Portugal in their ability to conserve and enhance the public realm, whilst making use of a combination of research methods customized to each stage and objective of the research. In order to provide a solid theoretical background for the study of planning for public realm conservation in WHC in Portugal, it was necessary to look into the epistemology of conservation and the construction and development of the heritage concept by reviewing international scholarly debates on conservation, and on public spaces and urban design. This research explores the gradual development of a ‘heritage debate’ at the international level and how a succession of events, charters and recommendations feed into theoretical and public debates to guide the development of the heritage conservation framework in Portugal. To identify and assess the effectiveness of conservation planning on the public realm, it enquired into the role of urban design within the urban conservation planning framework, as space, usually public space, is the object of study of urban design (Cohen, 1999). It became clear that effective legislation, technical organization and national planning (ICOMOS, 1967) are fundamental prerequisites to any official strategy of heritage conservation – something which Portugal lacked for a long time. As in other European cities, the trend has been to focus on public spaces renewal as the 'representation of the process of urban regeneration' (Hubbard, 1996: 1442), and whether this representation reflects the quality of the public realm achieved through urban heritage conservation is a matter for the analytical evaluation undertaken in a selected number of public spaces in Évora, Porto and Guimarães, the three illustrative case study cities of this research. The normative goal of the thesis is, ultimately, to contribute to making recommendations in order to improve the local implementation of national conservation policies, in particular through urban design guidelines that could guide local authorities in planning for the public realm conservation of their historic centres.
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- 2010
129. Re-use of previously developed land : housebuilder adaptation to a changing context
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Karadimitriou, N., Edwards, M., and de Magalhaes, C.
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307.1 - Abstract
Recent changes in UK urban policy are important contributors in shifting the way the built environment in the UK is produced. The thesis examines the effect this policy push has on the housebuilding sector, on the types of dwellings and developments produced and the efforts of two major London housebuilders to adapt. Since the mid 1990s, UK governments have emphasised the need to accommodate new housing provision on previously developed land, predominantly in urban areas. This changing business environment forces housebuilders to adapt. Opportunities open up as new inner city markets emerge, whereas obtaining planning permission for sites on previously undeveloped land is becoming increasingly difficult. These new markets and new types of land input require housebuilders to re organise their development practices. New types of dwellings and developments have to be designed, financed, produced and sold. Aggregate statistics for the housebuilding sector reveal that housing development is transforming: dwelling production in metropolitan areas is increasing, the proportion of flats is rising and densities are increasing. The examination of two firms and two of their projects also shows that both firms are responding to their new business environment. The first response puts emphasis on flexibility and has led to sustained growth whereas the other response, focused on spreading development risks geographically and amongst different markets, is proving to be less successful at the moment. Although this transformation is still unfolding, the insights from the research can already prove useful to policy makers and housebuilders. An examination of housebuilding based on ideas deriving from a combination of institutionalist and evolutionary approaches can open new pathways in the way we understand the housebuilding industry and therefore in the way we understand processes of production and consumption of the built environment and the significance of planning policy as an instigator of change.
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- 2007
130. Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial.
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Ruperto N, Lovell DJ, Quartier P, Paz E, Rubio-Pérez N, Silva CA, Abud-Mendoza C, Burgos-Vargas R, Gerloni V, Melo-Gomes JA, Saad-Magalhaes C, Sztajnbok F, Goldenstein-Schainberg C, Scheinberg M, Penades IC, Fischbach M, Orozco J, Hashkes PJ, Hom C, and Jung L
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BACKGROUND: Some children with juvenile idiopathic arthritis either do not respond, or are intolerant to, treatment with disease-modifying antirheumatic drugs, including anti-tumour necrosis factor (TNF) drugs. We aimed to assess the safety and efficacy of abatacept, a selective T-cell costimulation modulator, in children with juvenile idiopathic arthritis who had failed previous treatments. METHODS: We did a double-blind, randomised controlled withdrawal trial between February, 2004, and June, 2006. We enrolled 190 patients aged 6-17 years, from 45 centres, who had a history of active juvenile idiopathic arthritis; at least five active joints; and an inadequate response to, or intolerance to, at least one disease-modifying antirheumatic drug. All 190 patients were given 10 mg/kg of abatacept intravenously in the open-label period of 4 months. Of the 170 patients who completed this lead-in course, 47 did not respond to the treatment according to predefined American College of Rheumatology (ACR) paediatric criteria and were excluded. Of the patients who did respond to abatacept, 60 were randomly assigned to receive 10 mg/kg of abatacept at 28-day intervals for 6 months, or until a flare of the arthritis, and 62 were randomly assigned to receive placebo at the same dose and timing. The primary endpoint was time to flare of arthritis. Flare was defined as worsening of 30% or more in at least three of six core variables, with at least 30% improvement in no more than one variable. We analysed all patients who were treated as per protocol. This trial is registered, number NCT00095173. FINDINGS: Flares of arthritis occurred in 33 of 62 (53%) patients who were given placebo and 12 of 60 (20%) abatacept patients during the double-blind treatment (p=0.0003). Median time to flare of arthritis was 6 months for patients given placebo (insufficient events to calculate IQR); insufficient events had occurred in the abatacept group for median time to flare to be assessed (p=0.0002). The risk of flare in patients who continued abatacept was less than a third of that for controls during that double-blind period (hazard ratio 0.31, 95% CI 0.16-0.95). During the double-blind period, the frequency of adverse events did not differ in the two treatment groups. Adverse events were recorded in 37 abatacept recipients (62%) and 34 (55%) placebo recipients (p=0.47); only two serious adverse events were reported, both in controls (p=0.50). INTERPRETATION: Selective modulation of T-cell costimulation with abatacept is a rational alternative treatment for children with juvenile idiopathic arthritis. FUNDING: Bristol-Myers Squibb. [ABSTRACT FROM AUTHOR]
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- 2008
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131. Development and initial validation of the macrophage activation syndrome/primary hemophagocytic lymphohistiocytosis score, a diagnostic tool that differentiates primary hemophagocytic lymphohistiocytosis from macrophage activation syndrome
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Francesca Minoia, Francesca Bovis, Sergio Davì, Antonella Insalaco, Kai Lehmberg, Susan Shenoi, Sheila Weitzman, Graciela Espada, Yi-Jin Gao, Jordi Anton, Toshiyuki Kitoh, Ozgur Kasapcopur, Helga Sanner, Rosa Merino, Itziar Astigarraga, Maria Alessio, Michael Jeng, Vyacheslav Chasnyk, Kim E. Nichols, Zeng Huasong, Caifeng Li, Concetta Micalizzi, Nicolino Ruperto, Alberto Martini, Randy Q. Cron, Angelo Ravelli, AnnaCarin Horne, Mario Abinun, Amita Aggarwal, Jonathan Akikusa, Sulaiman Al-Mayouf, Maria Teresa Apaz, Tadej Avcin, Nuray Aktay Ayaz, Patrizia Barone, Bianca Bica, Isabel Bolt, Luciana Breda, Rolando Cimaz, Fabrizia Corona, Ruben Cuttica, Zane Davidsone, Carmen De Cunto, Jaime De Inocencio, Erkan Demirkaya, Eli M. Eisenstein, Sandra Enciso, Michel Fischbach, Michael Frosch, Romina Gallizzi, Maria Luz Gamir, Thomas Griffin, Alexei Grom, Soad Hashad, Teresa Hennon, Jan-Inge Henter, Gerd Horneff, Adam Huber, Norman Ilowite, Maka Ioseliani, Agneza Marija Kapović, Raju Khubchandani, Isabelle Koné-Paut, Sheila Knupp Feitosa de Oliveira, Bianca Lattanzi, Loredana Lepore, Jeffrey M. Lipton, Silvia Magni-Manzoni, Despoina Maritsi, Deborah McCurdy, Paivi Miettunen, Velma Mulaosmanovic, Susan Nielsen, Seza Ozen, Priyankar Pal, Sampath Prahalad, Donato Rigante, Ingrida Rumba-Rozenfelde, Ricardo Russo, Claudia Saad Magalhães, Wafaa Mohamed Saad Sewairi, Clovis Artur Silva, Valda Stanevicha, Gary Sterba, Kimo C. Stine, Gordana Susic, Flavio Sztajnbok, Syuji Takei, Ralf Trauzeddel, Elena Tsitsami, Erbil Unsal, Yosef Uziel, Olga Vougiouka, Carol A. Wallace, Lehn Weaver, Jennifer E. Weiss, Carine Wouters, Nico Wulffraat, Mabruka Zletni, Maurizio Arico, R. Maarten Egeler, Alexandra H. Filipovich, Helmut Gadner, Shinsaku Imashuku, Gritta Janka, Stephan Ladisch, Ken L. McClain, David Webb, Minoia, F., Bovis, F., Davi, S., Insalaco, A., Lehmberg, K., Shenoi, S., Weitzman, S., Espada, G., Gao, Y. -J., Anton, J., Kitoh, T., Kasapcopur, O., Sanner, H., Merino, R., Astigarraga, I., Alessio, M., Jeng, M., Chasnyk, V., Nichols, K. E., Huasong, Z., Li, C., Micalizzi, C., Ruperto, N., Martini, A., Cron, R. Q., Ravelli, A., Horne, A., Abinun, M., Aggarwal, A., Akikusa, J., Al-Mayouf, S., Apaz, M. T., Avcin, T., Ayaz, N. A., Barone, P., Bica, B., Bolt, I., Breda, L., Cimaz, R., Corona, F., Cuttica, R., Davidsone, Z., De Cunto, C., De Inocencio, J., Demirkaya, E., Eisenstein, E. M., Enciso, S., Fischbach, M., Frosch, M., Gallizzi, R., Gamir, M. L., Griffin, T., Grom, A., Hashad, S., Hennon, T., Henter, J. -I., Horneff, G., Huber, A., Ilowite, N., Ioseliani, M., Kapovic, A. M., Khubchandani, R., Kone-Paut, I., de Oliveira, S. K. F., Lattanzi, B., Lepore, L., Lipton, J. M., Magni-Manzoni, S., Maritsi, D., Mccurdy, D., Miettunen, P., Mulaosmanovic, V., Nielsen, S., Ozen, S., Pal, P., Prahalad, S., Rigante, D., Rumba-Rozenfelde, I., Russo, R., Magalhaes, C. S., Sewairi, W. M. S., Artur Silva, C., Stanevicha, V., Sterba, G., Stine, K. C., Susic, G., Sztajnbok, F., Takei, S., Trauzeddel, R., Tsitsami, E., Unsal, E., Uziel, Y., Vougiouka, O., Wallace, C. A., Weaver, L., E. Weiss, J., Wouters, C., Wulffraat, N., Zletni, M., Arico, M., Egeler, R. M., Filipovich, A. H., Gadner, H., Imashuku, S., Janka, G., Ladisch, S., Mcclain, K. L., and Webb, D.
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Male ,0301 basic medicine ,Hemophagocytic ,Logistic regression ,Pediatrics ,hemophagocytic syndrome ,0302 clinical medicine ,diagnostic score ,Diagnosis ,Medicine ,Cutoff ,Child ,primary hemophagocytic lymphohistiocytosi ,Lymphohistiocytosis ,education.field_of_study ,primary hemophagocytic lymphohistiocytosis ,Perinatology and Child Health ,Quartile ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Macrophage activation syndrome ,Child, Preschool ,macrophage activation syndrome ,Absolute neutrophil count ,Female ,Human ,medicine.medical_specialty ,Adolescent ,Population ,Lymphohistiocytosis, Hemophagocytic ,Diagnosis, Differential ,03 medical and health sciences ,Internal medicine ,Humans ,Preschool ,education ,030203 arthritis & rheumatology ,Receiver operating characteristic ,business.industry ,Infant ,Reproducibility of Results ,medicine.disease ,Surgery ,030104 developmental biology ,Macrophage Activation Syndrome ,Pediatrics, Perinatology and Child Health ,Differential ,Differential diagnosis ,business - Abstract
OBJECTIVE: To develop and validate a diagnostic score that assists in discriminating primary hemophagocytic lymphohistiocytosis (pHLH) from macrophage activation syndrome (MAS) related to systemic juvenile idiopathic arthritis. STUDY DESIGN: The clinical, laboratory, and histopathologic features of 362 patients with MAS and 258 patients with pHLH were collected in a multinational collaborative study. Eighty percent of the population was assessed to develop the score and the remaining 20% constituted the validation sample. Variables that entered the best fitted model of logistic regression were assigned a score, based on their statistical weight. The MAS/HLH (MH) score was made up with the individual scores of selected variables. The cutoff in the MH score that discriminated pHLH from MAS best was calculated by means of receiver operating characteristic curve analysis. Score performance was examined in both developmental and validation samples. RESULTS: Six variables composed the MH score: age at onset, neutrophil count, fibrinogen, splenomegaly, platelet count, and hemoglobin. The MH score ranged from 0 to 123, and its median value was 97 (1st-3rd quartile 75-123) and 12 (1st-3rd quartile 11-34) in pHLH and MAS, respectively. The probability of a diagnosis of pHLH ranged from 99% for a score of =123. A cutoff value of =60 revealed the best performance in discriminating pHLH from MAS. CONCLUSION: The MH score is a powerful tool that may aid practitioners to identify patients who are more likely to have pHLH and, thus, could be prioritized for functional and genetic testing.
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- 2017
132. Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
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Ravelli, A, Minoia, F, Davì, S, Horne, A, Bovis, F, Pistorio, A, Aricò, M, Avcin, T, Behrens, Em, De Benedetti, F, Filipovic, A, Grom, Aa, Henter, J-i, Ilowite, Nte, Jordan, Mb, Khubchandani, R, Kitoh, T, Lehmberg, K, Lovell, Dj, Miettunen, P, Nichols, Ke, Ozen, S, Schmid, Jp, Ramanan, Av, Russo, R, Schneider, R, Sterba, G, Uziel, Y, Wallace, C, Wouters, C, Wulffraat, N, Demirkaya, E, Brunner, Hi, Martini, A, Ruperto, N, Cron, Rq, Angioloni, S, Pallotti, C, Pesce, M, Rinaldi, M, Villa, L, Abinun, M, Aggarwal, A, Akikusa, J, Al-mayouf, Sm, Alessio, M, Anton, J, Apaz, Mt, Astigarraga, I, Ayaz, Na, Barone, P, Bica, B, Bolt, I, Breda, L, Chasnyk, V, Cimaz, R, Corona, F, Cuttica, R, D'Angelo, G, Davidsone, Z, De Cunto, C, De Inocencio, J, Eisenstein, E, Enciso, S, Espada, G, Fischbach, M, Frosch, M, Gallizzi, R, Gamir, Ml, Gao, Y-j, Griffin, T, Hashad, S, Hennon, T, Horneff, G, Huasong, Z, Huber, A, Insalaco, A, Ioseliani, M, Jelusic-drazic, M, Jeng, M, Kapovic, A, Kasapcopur, O, Kone-paut, I, De Oliveira Skf, Lattanzi, B, Lepore, L, Li, C, Lipton, Jm, Magni-manzoni, S, Maritsi, D, Mccurdy, D, Merino, R, Mulaosmanovic, V, Nielsen, S, Pal, P, Prahalad, S, Rigante, Donato, Rumba-rozenfelde, I, Magalhaes, Cs, Sanner, H, Sawhney, S, Sewairi, Wm, Shakoory, B, Shenoi, S, Clovis, As, Stanevicha, V, Stine, Kc, Susic, G, Sztajnbok, F, Takei, S, Tezer, H, Trauzeddel, R, Tsitsami, E, Unsal, E, Vougiouka, O, Weaver, Lk, Weiss, J, Weitzman, S, On Behalf Of The Pediatric Rheumatology International Trials Organization, Zletni M., The Childhood Arthritis & Rheumatology Research Alliance, The Pediatric Rheumatology Collaborative Study Group And The Histiocyte Society, Ravelli, A., Minoia, F., Davi, S., Horne, A., Bovis, F., Pistorio, A., Arico, M., Avcin, T., Behrens, E. M., De Benedetti, F., Filipovic, A., Grom, A. A., Henter, J. -I., Ilowite, N. T., Jordan, M. B., Khubchandani, R., Kitoh, T., Lehmberg, K., Lovell, D. J., Miettunen, P., Nichols, K. E., Ozen, S., Schmid, J. P., Ramanan, A. V., Russo, R., Schneider, R., Sterba, G., Uziel, Y., Wallace, C., Wouters, C., Wulffraat, N., Demirkaya, E., Brunner, H. I., Martini, A., Ruperto, N., Cron, R. Q., Angioloni, S., Pallotti, C., Pesce, M., Rinaldi, M., Villa, L., Abinun, M., Aggarwal, A., Akikusa, J., Al-Mayouf, S. M., Alessio, M., Anton, J., Apaz, M. T., Astigarraga, I., Ayaz, N. A., Barone, P., Bica, B., Bolt, I., Breda, L., Chasnyk, V., Cimaz, R., Corona, F., Cuttica, R., D'Angelo, G., Davidsone, Z., De Cunto, C., De Inocencio, J., Eisenstein, E., Enciso, S., Espada, G., Fischbach, M., Frosch, M., Gallizzi, R., Gamir, M. L., Gao, Y. -J., Griffin, T., Hashad, S., Hennon, T., Horneff, G., Huasong, Z., Huber, A., Insalaco, A., Ioseliani, M., Jelusic-Drazic, M., Jeng, M., Kapovic, A., Kasapcopur, O., Kone-Paut, I., De Oliveira, S. K. F., Lattanzi, B., Lepore, L., Li, C., Lipton, J. M., Magni-Manzoni, S., Maritsi, D., Mccurdy, D., Merino, R., Mulaosmanovic, V., Nielsen, S., Pal, P., Prahalad, S., Rigante, D., Rumba-Rozenfelde, I., Magalhaes, C. S., Sanner, H., Sawhney, S., Sewairi, W. M., Shakoory, B., Shenoi, S., Clovis, A. S., Stanevicha, V., Stine, K. C., Susic, G., Sztajnbok, F., Takei, S., Tezer, H., Trauzeddel, R., Tsitsami, E., Unsal, E., Vougiouka, O., Weaver, L. K., Weiss, J., Weitzman, S., Zletni, M., and Çocuk Sağlığı ve Hastalıkları
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medicine.medical_specialty ,systemic juvenile idiopathic arthritis ,Epidemiology ,Immunology ,Arthritis ,Bioinformatics ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Internal medicine ,medicine ,Journal Article ,Immunology and Allergy ,030212 general & internal medicine ,Juvenile Idiopathic Arthritis ,Prospective cohort study ,030203 arthritis & rheumatology ,medicine.diagnostic_test ,business.industry ,Paediatric Rheumatology ,medicine.disease ,Outcomes research ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Macrophage activation syndrome ,Erythrocyte sedimentation rate ,Absolute neutrophil count ,sense organs ,business - Abstract
OBJECTIVE: To identify which laboratory tests that change over time are most valuable for the timely diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA).METHODS: A multistep process, based on a combination of expert consensus and analysis of real patient data, was conducted. A panel of experts was first asked to evaluate 115 profiles of patients with MAS, which included the values of laboratory tests at the pre-MAS visit and at MAS onset, and the change in values between the two time points. The experts were asked to choose the 5 laboratory tests in which change was most important for the diagnosis of MAS and to rank the 5 selected tests in order of importance. The relevance of change in laboratory parameters was further discussed and ranked by the same experts at a consensus conference.RESULTS: Platelet count was the most frequently selected test, followed by ferritin level, aspartate aminotransferase (AST), white cell count, neutrophil count, and fibrinogen and erythrocyte sedimentation rate. Ferritin was most frequently assigned the highest score. At the end of the process, platelet count, ferritin level and AST were the laboratory tests in which the experts found change over time to be most important.CONCLUSIONS: We identified the laboratory tests in which change over time is most valuable for the early diagnosis of MAS in sJIA. The dynamics of laboratory values during the course of MAS should be further scrutinised in a prospective study in order to establish the optimal cut-off values for their variation.
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- 2016
133. The Ocean Sampling Day Consortium
- Author
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Oleksandra Bobrova, Petra ten Hoopen, Rodrigo Costa, Rania Siam, Rehab Z. Abdallah, Jorge A. Herrera Silveira, Catarina Magalhães, Nedime Serakinci, Marie E. DeLorenzo, Riccardo Rosselli, Paul Malthouse, Lise Øvreås, Eyjólfur Reynisson, Susan Gebbels, Francesca Malfatti, Frank Oliver Glöckner, Federico M. Lauro, Hans Erik Karlsen, David Wallom, Christian Jeanthon, Mark J. Costello, Fergal O'Gara, Nadezhda Todorova, Ana C. Costa, Monia El Bour, Paul D. van Ruth, Ivaylo Kostadinov, Martin Ostrowski, Jed A. Fuhrman, Viggo Marteinsson, Thierry Cariou, Hiroyuki Ogata, Maria Luiza Pedrotti, Emilie Villar, Federico Baltar, Sandi Orlić, Valentina Turk, Katja Lehmann, Dawn Field, Renzo Kottmann, Florence Jude-Lemeilleur, Daniel Vaulot, Alessandro Vezzi, Neil M Davies, Mahrous M. Kandil, Véronique Berteaux-Lecellier, Christopher D. Sinigalliano, Timothy W. Davis, Peter N. Golyshin, Stéphane L'Haridon, Jonathan A. Martinez, Sandra Ramos, Pascal Conan, Ma. Leopoldina Aguirre-Macedo, Antonio Fernandez-Guerra, Soumya Essayeh, Clara Loureiro, Edvardsen Bente, Noureddine Boukhatem, Rachelle M. Jensen, Sophie Pitois, Bouchra Chaouni, Kate Munnik, Anke Kremp, Stephane Pesant, Roberto Danovaro, Cecilia Alonso, Said Barrijal, Jodie van de Kamp, Michail M. Yakimov, Nicole J. Poulton, Zackary I. Johnson, Adriana Zingone, Bernardo Duarte, Ilkay Salihoglu, Paraskevi N. Polymenakou, Jack A. Gilbert, Melody S. Clark, Ian Salter, Hassan Ghazal, Julie LaRoche, J. Mortelmans, Ranjith Edirisinghe, Grazia Marina Quero, Dion Matthew Frederick Frampton, Isabel Caçador, Georgios Tsiamis, Declan C. Schroeder, Jamie Hinks, Ana Martins, Noga Stambler, Rachel Collin, João Canning-Clode, Tinkara Tinta, Mesude Bicak, Scott Jones, Valentina Amaral, Matthias S. Ullrich, Gunnar Gerdts, Klaas Deneudt, Michael Steinke, Mohamed Bennani, Rafael Santana, Fabio De Pascale, Jennifer Tolman, Juan Iriberri, Levente Bodrossy, Abderrahim Bouali, Antonella Penna, Bruno Cataletto, Josep M. Gasol, Florencia Biancalana, Maribeth L. Gidley, Stephen A. Jackson, Mahmut Cerkez Ergoren, Carolin R. Löscher, Antje Wichels, Ventzislav Karamfilov, R. Eric Collins, Sara Ettamimi, Riccardo Schiavon, Mohammed Timinouni, Christina Bienhold, Julia Schnetzer, Marc E. Frischer, Wayne J. Fuller, Simon Claus, Ibon Cancio, Guy Cochrane, Patrick Martin, Gian Marco Luna, Snejana Moncheva, Linda A. Amaral-Zettler, Eva C. Sonnenschein, Paul Anders Fronth Nyhus, Shiao Y. Wang, Antonina Dos Santos, Eyal Rahav, Eileen Bresnan, Anna Kopf, Barker Katherine, Michèle Barbier, Naiara Rodríguez-Ezpeleta, Kemal Can Bizsel, Tim Ingleton, Patricia Wecker, Julia A. Busch, Kelly D. Goodwin, El Houcine Zaid, Rajaa Chahboune, Takashi Yoshida, Fatima El Otmani, Marianna Mea, Nina Dzhembekova, Anne-Lise Ducluzeau, Christopher P. Meyer, Georgios Kotoulas, Max Planck Institute for Marine Microbiology, Max-Planck-Gesellschaft, Jacobs University [Bremen], University of Oxford, Centre for Ecology & Hydrology, Oxfordshire UK, Adaptation et diversité en milieu marin (AD2M), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Israel Oceanographic and Limnological Research (IOLR), Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), Hellenic Centre for Marine Research (HCMR), American University in Cairo, Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), University College Cork (UCC), Curtin University [Perth], Planning and Transport Research Centre (PATREC), Institut Ruder Boskovic, Institut Ruđer Bošković (IRB), University of Essex, Carl Von Ossietzky Universität Oldenburg = Carl von Ossietzky University of Oldenburg (OFFIS), Universidade de Lisboa = University of Lisbon (ULISBOA), Smithonian Environmental Research Center, Research Center, Odessa National I.I.Mechnikov University, Matis Ltd, Universidade dos Açores, Istituto di Science Marine (ISMAR ), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Helmholtz Centre for Ocean Research [Kiel] (GEOMAR), Finnish Environment Institute (SYKE), National Oceanic and Atmospheric Administration (NOAA), University of Bergen (UiB), Dalhousie University [Halifax], Università di Urbino, Skidaway Institute of Oceanography, Smithsonian Institution, Interdisciplinary Centre of Marine and Environmental Research [Matosinhos, Portugal] (CIIMAR), Universidade do Porto = University of Porto, Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Centro de Investigacion y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV), Mississippi State University [Mississippi], Bigelow Laboratory for Ocean Sciences, Smithsonian Marine Station, Smithsonian Tropical Research Institute, University of Southern California (USC), Laboratoire d'Océanographie Microbienne (LOMIC), Observatoire océanologique de Banyuls (OOB), Universidad de la República [Montevideo] (UDELAR), Bar-Ilan University [Israël], The Interuniversity Institute for marine Science in Eilat, IAMC-CNR, Istituto per l'Ambiente Marino Costiero &ndash, University of Otago [Dunedin, Nouvelle-Zélande], Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Macquarie University, South Australian Research and Development Institute (SARDI), South Australian Research and Development Institute, Flanders Marine Institute, VLIZ, Centre for Environment, Fisheries and Aquaculture Science [Weymouth] (CEFAS), University of Algarve [Portugal], Marine Biological Association of the UK, Department of Chemistry, Alexandria University [Alexandrie], Argentine Institute of Oceanography, Laboratoire d'océanographie de Villefranche (LOV), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Kyoto University, University of Tasmania [Hobart, Australia] (UTAS), Waters, wetlands & coasts Sydney, Lwande technologies Cape Town, AZTI (AZTI), AZTI, Centre de recherches insulaires et observatoire de l'environnement (CRIOBE), Université de Perpignan Via Domitia (UPVD)-École Pratique des Hautes Études (EPHE), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Université Mohammed Premier [Oujda], Université Mohammed V de Rabat [Agdal] (UM5), Université Sidi Mohamed Ben Abdellah (USMBA), Université Abdelmalek Essaâdi (UAE), Institut Pasteur du Maroc, Réseau International des Instituts Pasteur (RIIP), Faculty of Sciences, Rabat, Morocco., Bulgarian Academy of Sciences (BAS), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Université de Brest (UBO), Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), Università degli Studi di Padova = University of Padua (Unipd), Singapore centre for environmental life sciences engineering, Nanyang Technological University [Singapour], Indigo V Expeditions, Newcastle University [Newcastle], Instituto Português de Investigação do Mar e da Atmosfera (IPMA), Information génomique et structurale (IGS), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Universität Bremen, Istituto Nazionale di Geofisica e di Oceanografia Sperimentale (OGS), Rajarata University of Sri-Lanka (RUSL), University of Southern Mississippi (USM), Mediterranean Science Commission, National institute of biology Fornace, Near East University, Marine Scotland Marine Laboratory, Kind of Blue Project ABS, University of Oslo (UiO), Marine biology research station, Bangor University, Institute of Marine Sciences / Institut de Ciències del Mar [Barcelona] (ICM), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Fridtjof Nansen Institute of oceanology, Duke University [Durham], Miami University, Miami University [Ohio] (MU), Stazione Zoologica Anton Dohrn (SZN), Polytechnic University of Marche, University of Patras, British Antarctic Survey (BAS), Natural Environment Research Council (NERC), INSTIM, University of Alaska [Fairbanks] (UAF), University of Hawaii, University of Auckland [Auckland], Marine Biological Laboratory (MBL), University of Chicago, Brown University, Zhejiang University, Argonne National Laboratory [Lemont] (ANL), Department of Mathematics [Berkeley], University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), Repositório da Universidade de Lisboa, Kopf, A, Bicak, M, Kottmann, R, Schnetzer, J, Kostadinov, I, Lehmann, K, Fernandez-Guerra, A, Jeanthon, C, Rahav, E, Ullrich, M, Wichels, A, Gerdts, G, Polymenakou, P, Kotoulas, G, Siam, R, Abdallah, Rz, Sonnenschein, Ec, Cariou, T, O'Gara, F, Jackson, S, Orlic, S, Steinke, M, Busch, J, Duarte, B, Cacador, I, Canning-Clode, J, Bobrova, O, Marteinsson, V, Reynisson, E, Loureiro, Cm, Luna, Gm, Quero, Gm, Loscher, Cr, Kremp, A, Delorenzo, Me, Ovreas, L, Tolman, J, Laroche, J, Penna, A, Frischer, M, Davis, T, Katherine, B, Meyer, Cp, Ramos, S, Magalhaes, C, Jude-Lemeilleur, F, Aguirre-Macedo, Ml, Wang, S, Poulton, N, Jones, S, Collin, R, Fuhrman, Ja, Conan, P, Alonso, C, Stambler, N, Goodwin, K, Yakimov, Mm, Baltar, F, Bodrossy, L, Van De Kamp, J, Frampton, Dmf, Ostrowski, M, Van Ruth, P, Malthouse, P, Claus, S, Deneudt, K, Mortelmans, J, Pitois, S, Wallom, D, Salter, I, Costa, R, Schroeder, Dc, Kandil, Mm, Amaral, V, Biancalana, F, Santana, R, Pedrotti, Ml, Yoshida, T, Ogata, H, Ingleton, T, Munnik, K, Rodriguez-Ezpeleta, N, Berteaux-Lecellier, V, Wecker, P, Cancio, I, Vaulot, D, Bienhold, C, Ghazal, H, Chaouni, B, Essayeh, S, Ettamimi, S, Zaid, E, Boukhatem, N, Bouali, A, Chahboune, R, Barrijal, S, Timinouni, M, El Otmani, F, Bennani, M, Mea, M, Todorova, N, Karamfilov, V, ten Hoopen, P, Cochrane, G, L'Haridon, S, Bizsel, Kc, Vezzi, A, Lauro, Fm, Martin, P, Jensen, Rm, Hinks, J, Gebbels, S, Rosselli, R, De Pascale, F, Schiavon, R, dos Santos, A, Villar, E, Pesant, S, Cataletto, B, Malfatti, F, Edirisinghe, R, Silveira, Jah, Barbier, M, Turk, V, Tinta, T, Fuller, Wj, Salihoglu, I, Serakinci, N, Ergoren, Mc, Bresnan, E, Iriberri, J, Nyhus, Paf, Bente, E, Karlsen, He, Golyshin, Pn, Gasol, Jm, Moncheva, S, Dzhembekova, N, Johnson, Z, Sinigalliano, Cd, Gidley, Ml, Zingone, A, Danovaro, R, Tsiamis, G, Clark, M, Costa, Ac, El Bour, M, Martins, Am, Collins, Re, Ducluzeau, Al, Martinez, J, Costello, Mj, Amaral-Zettler, La, Gilbert, Ja, Davies, N, Field, D, Glockner, Fo, European Commission, University of Oxford [Oxford], Israel Oceanographic and Limnological Research - IOLR (ISRAEL), Danmarks Tekniske Universitet (DTU), Carl Von Ossietzky Universität Oldenburg, Universidade de Lisboa (ULISBOA), Consiglio Nazionale delle Ricerche (CNR), Universidade do Porto, UMR 5805 Environnements et Paléoenvironnements Océaniques et Continentaux (EPOC), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Universidad de la República [Montevideo] (UCUR), Kyoto University [Kyoto], Université de Perpignan Via Domitia (UPVD)-École pratique des hautes études (EPHE), University of Mohammed V, Sidi Mohammed Ben Abdellah University, Universita degli Studi di Padova, Rajarata University of Sri-Lanka, University of Patras [Patras], University of California [Berkeley], and University of California-University of California
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0106 biological sciences ,Biodiversity ,Marine life ,01 natural sciences ,Bacteria ,Genomics ,Health Index ,Marine ,Metagenomics ,Micro B3 ,Microorganism ,OSD ,Ocean sampling day ,Standards ,11. Sustainability ,Data and Information ,Ocean Sampling Day ,biodiversity ,genomics ,health index ,bacteria ,microorganism ,metagenomics ,marine ,standards ,[SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere ,0303 health sciences ,Ecology ,Environmental resource management ,Geology ,Computer Science Applications ,Interdisciplinary Natural Sciences ,Microbial biodiversity ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Ocean sampling day, OSD, Biodiversity, Genomics, Health Index, Bacteria, Microorganism, Metagenomics,Marine, Micro B3, Standards ,Oceans and Seas ,Microorganisms ,Marine Biology ,Health Informatics ,[SDV.BID]Life Sciences [q-bio]/Biodiversity ,Biology ,Ecology and Environment ,Metagenomic ,03 medical and health sciences ,Health index ,Medisinske Fag: 700 [VDP] ,SDG 14 - Life Below Water ,14. Life underwater ,030304 developmental biology ,business.industry ,010604 marine biology & hydrobiology ,Ocean sampling ,13. Climate action ,Commentary ,Genomic ,Database Management Systems ,Global Ocean ,business - Abstract
Kopf, Anna ... et. al.-- 5 pages, 1 figure.-- This manuscript is NOAA-GLERL contribution number 1763, Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world’s oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits, This work was supported by the Micro B3 project, which is funded from the European Union’s Seventh Framework Programme (FP7; Joint Call OCEAN.2011‐2: Marine microbial diversity – new insights into marine ecosystems functioning and its biotechnological potential) under the grant agreement no 287589
- Published
- 2015
134. O PROCESSO TRADUTÓRIO NA PERSPECTIVA DA RETEXTUALIZAÇÃO E SUA ABORDAGEM NO ENSINO DE INGLÊS COMO LÍNGUA ESTRANGEIRA
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CASTRO, M. C., MAGALHAES, C. M., FILGUEIRAS, L. V. P., DEPAULA, L., and CURRIE, K. L.
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ensino de língua estrangeira e tradução ,textualidade - Abstract
Made available in DSpace on 2016-08-29T15:08:45Z (GMT). No. of bitstreams: 1 tese_4295_DISSERTAÇÃO Mayelli Caldas de Castro.pdf: 4694231 bytes, checksum: 8767a4f5a69d5b5bef94c4271f7d0bc2 (MD5) Previous issue date: 2010-10-26 Esta pesquisa tem como objetivo geral fazer uma reflexão sobre o ato tradutório considerado como Retextualização. Pretendemos discutir a atividade de traduzir enquanto (re)produção textual, ou seja, produção de um novo/mesmo texto que se originou de uma língua diferente e reconhecer e examinar os fatores de textualidade que contribuíram para o processo de tradução. A partir dessa busca, concretizaremos o que consideramos ser o objetivo central deste trabalho: analisar a pertinência da abordagem desses textos traduzidos e a implicação que a tradução pode exercer sobre o entendimento do texto na sala de aula de língua inglesa e em relação ao público alvo que, nesta pesquisa, serão os estudantes de língua inglesa do Ensino Médio. Esta é uma abordagem da atividade tradutória que utiliza elementos da Linguística Textual, já que não se traduzem palavras isoladas, e, sim, textos. Então, trata-se de uma análise textual, com suas fases de produção e, onsequentemente, de coprodução. Para essa análise, procurou-se a abordagem de um conjunto de textos com finalidades didáticas que originalmente estão escritos em inglês e traduzidos para o português brasileiro; e recorreu-se aos fatores de textualização propostos por Beaugrande e Dressler como critérios definidores de textualidade e, também, aos componentes pragmáticos para ampliar as análises. Assim, a intenção principal desse trabalho é investigar e apontar quais mecanismos textuais são determinantes nas escolhas feitas pelo tradutor e, consequentemente, como a escolha vocabular pode interferir na função que esses mecanismos desempenham para entender sua implicação no ensino de língua inglesa.
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- 2010
135. Long-term outcome and prognostic factors of juvenile dermatomyositis: a multinational, multicenter study of 490 patients
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C Ferrari, Ruben Burgos-Vargas, Loredana Lepore, Virgínia Paes Leme Ferriani, Francesco Zulian, Elena Marzia Sala, Silvia Magni-Manzoni, MG Alpigiani, Angelo Ravelli, Nicolino Ruperto, Federica Rossi, Flavio Sztajnbok, Rosanna Podda, MM Katsicas, Ricardo Russo, Eunice Solis-Valleoj, Angela Pistorio, Valeria Gerloni, Elisabetta Cortis, S Maillard, Maria Alessio, Lucia Trail, Sheila Knupp Feitosa de Oliveira, Fabrizia Corona, Enrico Felici, Marcia Bandeira, Fernanda Falcini, Alberto Martini, Ruben Cuttica, Vicente Baca, Clovis A. Silva, Claudia Saad-Magalhães, Clarissa Pilkington, Matilde Beltramelli, Ist Ricovero & Cura Carattere Sci G Gaslini, Univ Genoa, Great Ormond St Hosp Sick Children, UCL, Universidade Federal do Rio de Janeiro (UFRJ), Universidade do Estado do Rio de Janeiro (UERJ), Hosp Gen Ninos Pedro de Elizalde, Fdn IRCCS Policlin, Hosp Pediat Juan P Garrahan, Universidade de São Paulo (USP), Hosp Gen Mexico City, Fdn Ist Ricovero & Cura Carattere Sci Policlin S, Ctr Med Natl La Raza, Hosp Pequeno Principe, Clin Pediat 1, Ctr Med Nacl Siglo XXI, Osped Pediat Bambino Gesu, Osped Villa Monna Tessa, Univ Naples Federico 2, Ist Ortoped Gaetano Pini, Universidade Estadual Paulista (Unesp), II Clin Pediat, Ist Ricovero & Cura Carattere Sci Burlo Garofalo, Ravelli, A, Trail, L, Ferrari, C, Ruperto, N, Pistorio, A, Pilkington, C, Maillard, S, Oliveira, Sk, Sztajnbok, F, Cuttica, R, Beltramelli, M, Corona, F, Katsicas, Mm, Russo, R, Ferriani, V, Burgos Vargas, R, Magni Manzoni, S, Solis Valleoj, E, Bandeira, M, Zulian, F, Baca, V, Cortis, E, Falcini, F, Alessio, Maria, Alpigiani, Mg, Gerloni, V, Saad Magalhaes, C, Podda, R, Silva, Ca, Lepore, L, Felici, E, Rossi, F, Sala, E, and Martini, A.
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Male ,medicine.medical_specialty ,Internationality ,Time Factors ,Adolescent ,Child ,Child, Preschool ,Cross-Sectional Studies ,Dermatomyositis ,Female ,Humans ,Infant ,Prognosis ,Retrospective Studies ,Treatment Outcome ,Cross-sectional study ,Rheumatology ,Quality of life ,Internal medicine ,Medicine ,Functional ability ,Preschool ,Juvenile dermatomyositis ,business.industry ,Mortality rate ,Retrospective cohort study ,medicine.disease ,Surgery ,Lipodystrophy ,business - Abstract
Made available in DSpace on 2013-08-12T19:10:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-15 Made available in DSpace on 2013-09-30T19:20:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-15 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:33:16Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T15:33:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-15 Myositis Association European Union Objective. To investigate the long-term outcome and prognostic factors of juvenile dermatomyositis (DM) through a multinational, multicenter study.Methods. Patients consisted of inception cohorts seen between 1980 and 2004 in 27 centers in Europe and Latin America. Predictor variables were sex, continent, ethnicity, onset year, onset age, onset type, onset manifestations, course type, disease duration, and active disease duration. Outcomes were muscle strength/endurance, continued disease activity, cumulative damage, muscle damage, cutaneous damage, calcinosis, lipodystrophy, physical function, and health-related quality of life (HRQOL).Results. A total of 490 patients with a mean disease duration of 7.7 years were included. At the cross-sectional visit, 41.2-52.8% of patients, depending on the instrument used, had reduced muscle strength/endurance, but less than 10% had severe impairment. Persistently active disease was recorded in 41.2-60.5% of the patients, depending on the activity measure used. Sixty-nine percent of the patients had cumulative damage. The frequency of calcinosis and lipodystrophy was 23.6% and 9.7%, respectively. A total of 40.7% of the patients had decreased functional ability, but only 6.5% had major impairment. Only a small fraction had decreased HRQOL. A chronic course, either polycyclic or continuous, consistently predicted a poorer outcome. Mortality rate was 3.1%.Conclusion. This study confirms the marked improvement in functional outcome of juvenile DM when compared with earlier literature. However, many patients had continued disease activity and cumulative damage at followup. A chronic course was the strongest predictor of poor prognosis. These findings highlight the need for treatment strategies that enable a better control of disease activity over time and the reduction of nonreversible damage. Ist Ricovero & Cura Carattere Sci G Gaslini, Genoa, Italy Univ Genoa, Genoa, Italy Great Ormond St Hosp Sick Children, London WC1N 3JH, England UCL, Inst Child Hlth, London, England Univ Fed Rio de Janeiro, Rio de Janeiro, Brazil Universidade do Estado do Rio de Janeiro (UERJ), BR-20550011 Rio de Janeiro, Brazil Hosp Gen Ninos Pedro de Elizalde, Buenos Aires, DF, Argentina Fdn IRCCS Policlin, Milan, Italy Hosp Pediat Juan P Garrahan, Buenos Aires, DF, Argentina Univ São Paulo, Fac Med Ribeirao Preto, Hosp Clin, Ribeirao Preto, Brazil Hosp Gen Mexico City, Mexico City, DF, Mexico Fdn Ist Ricovero & Cura Carattere Sci Policlin S, Pavia, Italy Ctr Med Natl La Raza, Mexico City, DF, Mexico Hosp Pequeno Principe, Curitiba, Parana, Brazil Clin Pediat 1, Padua, Italy Ctr Med Nacl Siglo XXI, Mexico City, DF, Mexico Osped Pediat Bambino Gesu, Rome, Italy Osped Villa Monna Tessa, Florence, Italy Univ Naples Federico 2, Naples, Italy Ist Ortoped Gaetano Pini, Milan, Italy Univ estadual Paulista, Botucatu, SP, Brazil II Clin Pediat, Cagliari, Italy Univ São Paulo, São Paulo, Brazil Ist Ricovero & Cura Carattere Sci Burlo Garofalo, Trieste, Italy Univ estadual Paulista, Botucatu, SP, Brazil EU: AML/B7-311/970666/II-0246-FI
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- 2010
136. A Hammerstein-type result for a semilinear parabolic problem
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GROSSINHO M. R, OMARI, PIERPAOLO, L. MAGALHAES, C. ROCHA AND L. SANCHEZ ED.S, GROSSINHO M., R, and Omari, Pierpaolo
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non-resonance ,Semilinear parabolic problem ,Dirichlet-periodic problem - Published
- 1997
137. A protocol for scoping reviews on the role of whole-body and dedicated body-part magnetic resonance imaging for assessment of adult and juvenile idiopathic inflammatory myopathies.
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Essouma M, de Araujo DB, Day J, Conticini E, Riopel MA, Elias AM, Paula VT, Omori CH, Guimarães JB, Gibson D, Saad-Magalhaes C, Appenzeller S, Schiffenbauer A, Machado PM, Feldman BM, Paik JJ, Christopher-Stine L, Rider LG, Reed A, van der Kooi AJ, Marrani E, Naddaf E, Kirkhus E, Sanner H, Bauer-Ventura I, Lilleker JB, Gupta L, Lucchini M, Dimachkie MM, Tolend M, Arabi TMA, Moghadam-Kia S, O'Hanlon S, Phaneuf S, Shinjo SK, and Doria AS
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- Humans, Child, Adult, Whole Body Imaging methods, Research Design, Magnetic Resonance Imaging methods, Myositis diagnostic imaging, Muscle, Skeletal diagnostic imaging
- Abstract
Currently, standardized magnetic resonance imaging (MRI) scoring systems and protocols for assessment of idiopathic inflammatory myopathies (IIMs) in children and adults are lacking. Therefore, we will perform a scoping review of the literature to collate and evaluate the existing semi-quantitative and quantitative MRI scoring systems and protocols for the assessment and monitoring of skeletal muscle involvement in patients with IIMs. The aim is to compile evidence-based information that will facilitate the future development of a universal standardized MRI scoring system for both research and clinical applications in IIM. A systematic search of electronic databases (PubMed, EMBASE, and Cochrane) will be undertaken to identify relevant articles published between January 2000 and October 2023. Data will be synthesized narratively. This scoping review seeks to comprehensively summarize and evaluate the evidence on the scanning protocols and scoring systems used in the assessment of diagnosis, disease activity, and damage using skeletal muscle MRI in IIMs. The results will allow the development of consensus recommendations for clinical practice and enable the standardization of research methods for the MRI assessment of skeletal muscle changes in patients with IIMs., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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138. Development of CARRA/PReS-endorsed consensus Core and Expanded Datasets in childhood-onset systemic lupus erythematosus for international registry-based research.
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Sadun RE, Cooper JC, Belot A, Avcin T, Aggarwal A, Ainsworth J, Akinsete A, Ardoin SP, Beresford MW, Bortey L, Brunner HI, Chang JC, Ciurtin C, Daftary A, Eberhard B, Feldman CH, Hedrich CM, Hersh AO, Hiraki LT, Isenberg DA, Kamphuis S, Knight AM, Lambert L, Levy DM, Marks SD, Maxwell N, Migowa A, Moore K, Ozen S, Ramsey-Goldman R, Ravelli A, Reeve BB, Rubinstein TB, Saad-Magalhaes C, Sawhney S, Schanberg LE, von Scheven E, Scott C, Son MB, Tony G, Weitzman ER, Wenderfer SE, Woodside A, Lewandowski LB, and Smith EM
- Abstract
Objectives: Childhood-onset systemic lupus erythematosus (cSLE), representing 15%-20% of individuals with SLE, has been difficult to study globally due to differences between registries. This initiative, supported by Childhood Arthritis Rheumatology Research Alliance (CARRA) and Paediatric Rheumatology European Society (PReS), aims to create Core and Expanded cSLE Datasets to standardise and enhance research worldwide., Methods: 21 international cSLE experts and 4 patients participated in a Delphi process (questionnaires, 2 topic-specific focus groups and 3 virtual consensus meetings) to create 2 standardised cSLE datasets. The Core cSLE Dataset was designed to include data essential to meaningful clinical research across many settings. The Expanded cSLE Dataset was designed for centres able to consistently collect data to address broader research questions. Final data items for the Core and Expanded datasets were determined by consensus defined as >80% agreement) using an adapted nominal group technique and voting., Results: The resulting Core cSLE Dataset contains 46 items, including demographics, clinical features, laboratory results, medications and significant adverse events. The Expanded cSLE Dataset adds 26 additional items and includes patient-reported outcomes. Consensus was also achieved regarding the frequency and time points for data collection: baseline, quarterly follow-up visits, annually and flare visits., Conclusion: Standardised Core and Expanded cSLE Datasets for registry-based international cSLE research were defined through the consensus of global experts and patient/caregiver representatives, endorsed by CARRA and PReS. These datasets incorporate disease-specific and patient-specific features, optimised for diverse settings to facilitate international collaborative research for children and adolescents with SLE worldwide., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ on behalf of EULAR.)
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- 2024
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139. Longitudinal assessment of disease activity and muscle strength in juvenile dermatomyositis: a multicentre registry study.
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Hortelan Antonio D, Carneiro BOL, Fernandes TAP, Elias AM, Pantoja de Moraes AJ, Vecchi AP, Cavalcanti A, Rabelo CN Jr, Magalhaes CM, Sztajnbok FR, Carvalho LM, Paim Marques L, Terreri MT, Fraga MM, de Oliveira SKF, Sacchetti SB, Appenzeller S, Robazzi T, Ferriani VPL, Len CA, Silva CAA, and Saad-Magalhaes C
- Abstract
Objectives: To define disease activity measures, muscle strength and functional assessments in new-onset juvenile dermatomyositis (JDM) patients, at disease onset and follow up., Methods: A registry was set up in 18 hospitals, enrolling patients over 3-years (2015-2018). Clinical assessments were performed at baseline, and at 6, 12, 18 and 24 months after diagnosis. Disease Activity Score (DAS20), skin and musculoskeletal DAS sub-scales; Manual Muscle Test (MMT8); Childhood Myositis Assessment Scale (CMAS); Childhood Health Assessment Questionnaire disability index (CHAQ_DI 0-3) and 10 cm Visual Analog Scale (VAS) for overall wellbeing scores were compared by Poisson Model and Wald post-test for repeated measures., Results: Ninety-six cases, being 61 (64%) females, median age 10 years had JDM diagnosis and 12 (13%) onset calcinosis. Mean ±SD scores at diagnosis and 6 months intervals for DAS20 (0-20) were 7.8±5, 6.3 ±4.8, 5±4, 4.9 ±5 and 0.5 ±2.3; with significant difference from baseline (p<0.01). Skin DAS subscales were 2.8±3.3, 1.8±2.9, 1,1±2.2, 0.6±1.8, 0.4±1.5. MMT (0-80) 62.6±20.4, 70.2±13.5, 73.3±11, 75.7±7.9 and 74.8±7.8, with significant difference from baseline up to 6 months (p=0.016); CMAS (0-53) 29.5±11.4, 33.1±8.3, 34.2±5.8, 34±6 and 33.3±5.4. CHAQ-DI (0-3) 1±0.9, 0.6±0.7, 0.8±0.8, 1±0.8 and 1±0.3; parents VAS 4.1±2.5, 2±2.1; 1.3±2.8, 4.1±3.1, 1.7±2.2. There was no significant difference for CMAS, CHAQ-DI and parents VAS from baseline up to 24-month assessment., Conclusions: DAS20 scores improved gradually during follow up, MMT8 improved significantly during the first 6 months and CMAS, CHAQ-DI and parents VAS scores had no significant improvement with persistent functional impairment over 2-years.
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- 2024
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140. Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse.
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Amargant F, Magalhaes C, Pritchard MT, and Duncan FE
- Abstract
The female reproductive system is one of the first to age in humans, resulting in infertility and endocrine disruptions. The aging ovary assumes a fibro-inflammatory milieu which negatively impacts gamete quantity and quality as well as ovulation. Here, we tested whether the systemic delivery of anti-inflammatory (Etanercept) or anti-fibrotic (Pirfenidone) drugs attenuates ovarian aging in mice. We first evaluated the ability of these drugs to decrease the expression of fibro-inflammatory genes in primary ovarian stromal cells treated with a pro-fibrotic or a pro-inflammatory stimulus. Whereas Etanercept did not block Tnf expression in ovarian stromal cells, Pirfenidone significantly reduced Col1a1 expression. We then tested Pirfenidone in vivo where the drug was delivered systemically via mini-osmotic pumps for 6 weeks. Pirfenidone mitigated the age-dependent increase in ovarian fibrosis without impacting overall health parameters. Ovarian function was improved in Pirfenidone-treated mice as evidenced by increased follicle and corpora lutea number, AMH levels, and improved estrous cyclicity. Transcriptomic analysis revealed that Pirfenidone treatment resulted in an upregulation of reproductive function-related genes at 8.5 months and a downregulation of inflammatory genes at 12 months of age. These findings demonstrate that reducing the fibroinflammatory ovarian microenvironment improves ovarian function, thereby supporting modulating the ovarian environment as a therapeutic avenue to extend reproductive longevity., (© 2024. The Author(s), under exclusive licence to American Aging Association.)
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- 2024
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141. Effect of T2-T4 sympathicotomy in skin temperature of pediatric patients with hyperhidrosis: a thermographic follow-up.
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Carvalho F, Magalhaes C, Fernandez-Llimos F, Mendes J, and Gonçalves J
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- Humans, Child, Male, Female, Follow-Up Studies, Adolescent, Thoracic Vertebrae surgery, Hyperhidrosis surgery, Hyperhidrosis physiopathology, Skin Temperature physiology, Sympathectomy methods, Thermography methods
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- 2024
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142. Childhood-onset systemic lupus erythematosus (cSLE) and malignancy: a nationwide multicentre series review.
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Brufatto MZ, Lanças SHS, de Albuquerque Pedrosa Fernandes T, Sallum AME, Campos LMA, Sakamoto AP, Terreri MT, Sztajnbok FR, Bica BERG, Ferriani VPL, de Carvalho LM, Silva CAA, and Saad-Magalhaes C
- Subjects
- Child, Female, Humans, Male, Young Adult, Age of Onset, Retrospective Studies, Carcinoma complications, Lupus Erythematosus, Systemic complications
- Abstract
Background: Increased malignancy frequency is well documented in adult-systemic lupus erythematosus (SLE), but with limited reports in childhood-onset SLE (cSLE) series. We explored the frequency of malignancy associated with cSLE, describing clinical and demographic characteristics, disease activity and cumulative damage, by the time of malignancy diagnosis., Method: A retrospective case-notes review, in a nationwide cohort from 27 Pediatric Rheumatology centres, with descriptive biopsy-proven malignancy, disease activity/damage accrual, and immunosuppressive treatment were compiled in each participating centre, using a standard protocol., Results: Of the 1757 cSLE cases in the updated cohort, 12 (0.7%) developed malignancy with median time 10 years after cSLE diagnosis. There were 91% females, median age at cSLE diagnosis 12 years, median age at malignancy diagnosis 23 years. Of all diagnosed malignancies, 11 were single-site, and a single case with concomitant multiple sites; four had haematological (0.22%) and 8 solid malignancy (0.45%). Median (min-max) SLEDAI-2 K scores were 9 (0-38), median (min-max) SLICC/ACR-DI (SDI) score were 1 (1-5) Histopathology defined 1 Hodgkin's lymphoma, 2 non-Hodgkin's lymphoma, 1 acute lymphoblastic leukaemia; 4 gastrointestinal carcinoma, 1 squamous cell carcinoma of the tongue and 1 anal carcinoma; 1 had sigmoid adenocarcinoma and 1 stomach carcinoid; 3 had genital malignancy, being 1 vulvae, 1 cervix and 1 vulvae and cervix carcinomas; 1 had central nervous system oligodendroglioma; and 1 testicle germ cell teratoma., Conclusion: Estimated malignancy frequency of 0.7% was reported during cSLE follow up in a multicentric series. Median disease activity and cumulative damage scores, by the time of malignancy diagnoses, were high; considering that reported in adult series., (© 2024. The Author(s).)
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- 2024
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143. Towards development of treat to target (T2T) in childhood-onset systemic lupus erythematosus: PReS-endorsed overarching principles and points-to-consider from an international task force.
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Smith EMD, Aggarwal A, Ainsworth J, Al-Abadi E, Avcin T, Bortey L, Burnham J, Ciurtin C, Hedrich CM, Kamphuis S, Levy DM, Lewandowski LB, Maxwell N, Morand EF, Ozen S, Pain CE, Ravelli A, Saad Magalhaes C, Pilkington CA, Schonenberg-Meinema D, Scott C, Tullus K, and Beresford MW
- Subjects
- Adult, Child, Humans, Surveys and Questionnaires, Remission Induction, Advisory Committees, Quality of Life, Lupus Erythematosus, Systemic drug therapy
- Abstract
Objectives: Application of 'treat-to-target' (T2T) in childhood-onset systemic lupus erythematosus (cSLE) may improve care and health outcomes. This initiative aimed to harmonise existing evidence and expert opinion regarding T2T for cSLE., Methods: An international T2T Task Force was formed of specialists in paediatric rheumatology, paediatric nephrology, adult rheumatology, patient and parent representatives. A steering committee formulated a set of draft overarching principles and points-to-consider, based on evidence from systematic literature review. Two on-line preconsensus meeting Delphi surveys explored healthcare professionals' views on these provisional overarching principles and points-to-consider. A virtual consensus meeting employed a modified nominal group technique to discuss, modify and vote on each overarching principle/point-to-consider. Agreement of >80% of Task Force members was considered consensus., Results: The Task Force agreed on four overarching principles and fourteen points-to-consider. It was agreed that both treatment targets and therapeutic strategies should be subject to shared decision making with the patient/caregivers, with full remission the preferred target, and low disease activity acceptable where remission cannot be achieved. Important elements of the points-to-consider included: aiming for prevention of flare and organ damage; glucocorticoid sparing; proactively addressing factors that impact health-related quality of life (fatigue, pain, mental health, educational challenges, medication side effects); and aiming for maintenance of the target over the long-term. An extensive research agenda was also formulated., Conclusions: These international, consensus agreed overarching principles and points-to-consider for T2T in cSLE lay the foundation for future T2T approaches in cSLE, endorsed by the Paediatric Rheumatology European Society., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)
- Published
- 2023
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144. Risk factors for mortality in 1528 Brazilian childhood-onset systemic lupus erythematosus patients.
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Sakamoto AP, Silva CA, Pita AC, Trindade VC, Islabao AG, Fiorot FJ, Lopes SR, Pereira RM, Saad-Magalhaes C, Russo GC, Len CA, Prado RD, Campos LM, Aikawa NE, Appenzeller S, Ferriani VP, Silva MF, Felix M, Fonseca AR, Assad AP, Sztajnbok FR, Santos MC, Bica BE, Sena EG, Moraes AJ, Fraga MM, Robazzi TC, Spelling PF, Scheibel IM, Cavalcanti AS, Matos EN, Guimaraes LJ, Santos FP, Mota LM, Bonfa E, and Terreri MT
- Subjects
- Child, Humans, Female, Male, Brazil epidemiology, Retrospective Studies, Age of Onset, Risk Factors, Lupus Erythematosus, Systemic complications, Renal Insufficiency, Chronic complications
- Abstract
Objectives: To identify associations between mortality in cSLE patients and their characteristics: clinical and laboratory features, disease activity and damage scores, and treatment; to evaluate risk factors associated with mortality in cSLE; and to determine the most frequent causes of death in this group of patients., Methods: We performed a multicenter retrospective cohort using data from 1,528 cSLE patients followed in 27 pediatric rheumatology tertiary centers in Brazil. Patients' medical records were reviewed according to a standardized protocol, in which information regarding demographic and clinical features, disease activity and damage scores, and treatment were collected and compared between deceased cSLE patients and survivors. Univariate and multivariate analyses by Cox regression model were used to calculate risk factors for mortality, whereas survival rates were analyzed by Kaplan-Meier plots., Results: A total of 63/1,528 (4.1%) patients deceased, 53/63 were female (84.1%), median age at death was 11.9 (9.4-13.1) years and median time interval between cSLE diagnosis and death was 3.2 (0.5-5.3) years. Sepsis was the main cause of death in 27/63 (42.8%) patients, followed by opportunistic infections in 7/63 (11.1%), and alveolar hemorrhage in 6/63 (9.5%) patients. The regression models resulted in neuropsychiatric lupus (NP-SLE) (HR = 2.56, 95% CI = 1.48-4.42) and chronic kidney disease (CKD) (HR = 4.33, 95% CI = 2.33-4.72), as risk factors significantly associated with mortality. Overall patient survival after cSLE diagnosis at 5, 10, and 15 years were 97%, 95.4%, and 93.8%, respectively., Conclusions: This study confirmed that the recent mortality rate in cSLE in Brazil is low, but still of concern. NP-SLE and CKD were the main risk factors for mortality, indicating that the magnitude of these manifestations was significantly high.
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- 2023
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145. Skin temperature response to thermal stimulus in patients with hyperhidrosis: A comparative study.
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Carvalho F, Magalhaes C, Fernandez-Llimos F, Mendes J, and Gonçalves J
- Subjects
- Body Temperature Regulation physiology, Child, Humans, Skin blood supply, Sweating, Temperature, Hyperhidrosis diagnosis, Hyperhidrosis surgery, Skin Temperature
- Abstract
Primary hyperhidrosis (HH), the excessive sweating exceeding physiological demand, has been associated to a complex dysfunction of the autonomic nervous system which may explain the disfunction in sweating but may also cause unrevealed alterations in skin blood flow regulation. In fact, HH patients present a sympathetic over-function with less reflex bradycardia in response to the Valsalva maneuver and higher sympathetic skin responses. We aimed to identify response patterns to room thermal stimulus in HH patients compared to a control group in order to investigate putative differences in blood flow assuming that skin temperature in glabrous (non-hairy) areas reflect the sympathetic tone in arteriovenous anastomoses (AVAs). Infrared thermography images were obtained from a cohort of patients diagnosed with HH, followed at a hospital pediatric surgical department and to a sex- and age-matched control group of patients admitted for other surgical procedures. With the participants in Fowler's position, a set of 3 images were captured simultaneously and 44 regions of interest were analyzed, distributed on the palms of the hands, soles of the feet, axilla, and inner canthus. After an acclimatization period at 20 °C, the room temperature was increased to 24, 28 and 32 °C to obtain similar sets of thermograms. A total of 37 patients with HH and 16 participants in the control group were included in the study. At baseline (20 °C), body core temperature (measured in the inner canthus) was significantly higher in the HH patients compared to the controls (p = 0.019 and p = 0.003 in right and left inner canthi, respectively), without any significant differences in the other thermograms. When room temperature was increased, differences in core temperature disappeared, while differences appeared in axilla and palms of the hands with HH patients presenting significantly lower temperature at the three thermal stimulus stages. Patients with HH presented a lower thermoregulatory response when submitted to room temperature increase, which may reflect a vasomotor sympathetic over-function in AVAs., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Fatima Carvalho reports financial support was provided by Fundação para a Ciência e Tecnologia., (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2022
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146. International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis.
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Chalhoub NE, Wenderfer SE, Levy DM, Rouster-Stevens K, Aggarwal A, Savani SI, Ruth NM, Arkachaisri T, Qiu T, Merritt A, Onel K, Goilav B, Khubchandani RP, Deng J, Fonseca AR, Ardoin SP, Ciurtin C, Kasapcopur O, Jelusic M, Huber AM, Ozen S, Klein-Gitelman MS, Appenzeller S, Cavalcanti A, Fotis L, Lim SC, Silva RM, Miramontes JR, Rosenwasser NL, Saad-Magalhaes C, Schonenberg-Meinema D, Scott C, Silva CA, Enciso S, Terreri MT, Torres-Jimenez AR, Trachana M, Al-Mayouf SM, Devarajan P, Huang B, and Brunner HI
- Subjects
- Adolescent, Age of Onset, Child, Female, Humans, Male, Retrospective Studies, Glucocorticoids administration & dosage, Lupus Erythematosus, Systemic complications, Lupus Erythematosus, Systemic drug therapy, Lupus Nephritis etiology
- Abstract
Objective: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology., Methods: Parameters influencing corticosteroid (CS) dosing were identified (step 1). Data from children with proliferative LN were used to generate patient profiles (step 2). Physicians rated changes in renal and extrarenal childhood-onset SLE activity between 2 consecutive visits and proposed CS dosing (step 3). The SSR was developed using patient profile ratings (step 4), with refinements achieved in a physician focus group (step 5). A second type of patient profile describing the course of childhood-onset SLE for ≥4 months since kidney biopsy was rated to validate the SSR-recommended oral and intravenous (IV) CS dosages (step 6). Patient profile adjudication was based on majority ratings for both renal and extrarenal disease courses, and consensus level was set at 80%., Results: Degree of proteinuria, estimated glomerular filtration rate, changes in renal and extrarenal disease activity, and time since kidney biopsy influenced CS dosing (steps 1 and 2). Considering these parameters in 5,056 patient profile ratings from 103 raters, and renal and extrarenal course definitions, CS dosing rules of the SSR were developed (steps 3-5). Validation of the SSR for up to 6 months post-kidney biopsy was achieved with 1,838 patient profile ratings from 60 raters who achieved consensus for oral and IV CS dosage in accordance with the SSR (step 6)., Conclusion: The SSR represents an international consensus on CS dosing for use in patients with childhood-onset SLE and proliferative LN. The SSR is anticipated to be used for clinical care and to standardize CS dosage during clinical trials., (© 2021, American College of Rheumatology.)
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- 2022
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147. Bilateral assessment of body core temperature through axillar, tympanic and inner canthi thermometers in a young population.
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Vardasca R, Magalhaes C, Marques D, Moreira J, Frade R, Seixas A, Mendes J, and Ring F
- Subjects
- Female, Humans, Male, Young Adult, Body Temperature, Thermometers, Tympanic Membrane
- Abstract
There are several sites in which the human body core temperature can be estimated and used to identify febrile states in a threat of pandemic situations at high-populational-traffic places (e.g. airports, ports, universities, schools, public buildings). In these locations, a fast method is required for temperature screening of masses. The most common methods are axillar and tympanic thermometers. However, in addition, measurement of the inner canthi (IC) of the eye with infrared thermal (IRT) imaging has been suggested as a fast mass measurement screening tool., Objective: It is the aim of this research to identify the bilateral difference of the available body temperature screening methods with potential use for large-scale fever screening and to verify if such a difference is acceptable., Approach: A total of 206 young participants (104 females and 102 males) were recruited, having their temperatures taken with the different methods bilaterally under neutral environmental conditions. The obtained results were statistically processed., Main Results: Results established absent reference data for site and method in west European populations. The bilateral differences were minor using the IC of the eye monitored with infrared imaging, which was also proved with the Bland-Altmann limits of agreement., Significance: Based on the findings of this research, despite all methods being able to estimate body core temperature, it is suggested to use IRT images of the IC of the eye, due to its fast, reliable and reproducible procedure for mass screening. Further research is required to understand the higher bilateral variability in using the traditional thermometer axilla and tympanic membrane assessments, since these are the methods currently used within a clinical setup. The same procedure must be applied to fever cases to establish a decision threshold per method.
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- 2019
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148. The role of AI classifiers in skin cancer images.
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Magalhaes C, Mendes J, and Vardasca R
- Subjects
- Algorithms, Dermoscopy methods, Forecasting, Humans, Microscopy methods, Photography methods, Spectrum Analysis methods, Artificial Intelligence, Skin Neoplasms diagnosis
- Abstract
Background: The use of different imaging modalities to assist in skin cancer diagnosis is a common practice in clinical scenarios. Different features representative of the lesion under evaluation can be retrieved from image analysis and processing. However, the integration and understanding of these additional parameters can be a challenging task for physicians, so artificial intelligence (AI) methods can be implemented to assist in this process. This bibliographic research was performed with the goal of assessing the current applications of AI algorithms as an assistive tool in skin cancer diagnosis, based on information retrieved from different imaging modalities., Materials and Methods: The bibliography databases ISI Web of Science, PubMed and Scopus were used for the literature search, with the combination of keywords: skin cancer, skin neoplasm, imaging and classification methods., Results: The search resulted in 526 publications, which underwent a screening process, considering the established eligibility criteria. After screening, only 65 were qualified for revision., Conclusion: Different imaging modalities have already been coupled with AI methods, particularly dermoscopy for melanoma recognition. Learners based on support vector machines seem to be the preferred option. Future work should focus on image analysis, processing stages and image fusion assuring the best possible classification outcome., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2019
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149. Biomedical musculoskeletal applications of infrared thermal imaging on arm and forearm: A systematic review.
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Vardasca R, Magalhaes C, Silva P, Abreu P, Mendes J, and Restivo MT
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- Arm physiology, Bone Diseases diagnostic imaging, Forearm physiology, Humans, Infrared Rays, Muscular Diseases diagnostic imaging, Skin Temperature, Arm diagnostic imaging, Forearm diagnostic imaging, Thermography methods
- Abstract
Infrared thermal imaging (IRT) has been a target of research for biomedical musculoskeletal applications, due to the possible association of the physiological data that it provides, through skin temperature measurement, with pathological states. The aim of this systematic review is to acquaint the outcomes of the biomedical application of IRT in arm and forearm evaluation and its future perspectives of research. During the literature review, 926 articles were identified using the search engines PubMed and Scopus, and 10 articles were retrieved from other sources. After screening the abstracts and applying the eligibility criteria on those which were fully accessible, 33 articles were included in the review. It can be observed that IRT has the potential to provide physiological information on the arm and forearm, showing potential to serve as an aid in various pathologies and health situations. Future studies and challenges are identified and proposed, facilitating the improvement and acceptance of the application of IRT in the assessment of arm and forearm' health status., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
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150. Juvenile arthritis management in less resourced countries (JAMLess): consensus recommendations from the Cradle of Humankind.
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Scott C, Chan M, Slamang W, Okong'o L, Petty R, Laxer RM, Katsicas MM, Fredrick F, Chipeta J, Faller G, Pileggi G, Saad-Magalhaes C, Wouters C, Foster HE, Kubchandani R, Ruperto N, and Russo R
- Subjects
- Adolescent, Child, Consensus, Delphi Technique, Developing Countries, Humans, Young Adult, Antirheumatic Agents therapeutic use, Arthritis, Juvenile drug therapy, Disease Management, Rheumatologists education
- Abstract
Juvenile idiopathic arthritis (JIA) is the most prevalent chronic rheumatic disease in children and young people (CYP) and a major cause of pain and disability. The vast majority of the world's children and their families live in less resourced countries (LRCs) and face significant socioeconomic and healthcare challenges. Current recommendations for standards of care and treatment for children with JIA do not consider children living in less resourced countries. In order to develop appropriate recommendations for the care of CYP with JIA in less resourced countries a meeting of experienced pediatric rheumatologists from less resourced countries was convened with additional input from a steering group of international pediatric rheumatologists with experience in developing recommendations and standards of care for JIA. Following a needs assessment survey of healthcare workers caring for CYP with JIA in LRC, a literature review was carried out and management recommendations formulated using Delphi technique and a final consensus conference. Responses from the needs assessment were received from 121/483 (25%) practitioners from 25/49 (51%) less resourced countries. From these responses, the initial 84 recommendations were refined and expanded through a series of 3 online Delphi rounds. A final list of 90 recommendations was proposed for evaluation. Evidence for each statement was reviewed, graded, and presented to the consensus group. The degree of consensus, level of agreement, and level of evidence for these recommendations are reported. Recommendations arrived at by consensus for CYP with JIA in less resourced countries cover 5 themes: (1) diagnosis, (2) referral and monitoring, (3) education and training, (4) advocacy and networks, and (5) research. Thirty-five statements were drafted. All but one statement achieved 100% consensus. The body of published evidence was small and the quality of evidence available for critical appraisal was low. Our recommendations offer novel insights and present consensus-based strategies for the management of JIA in less resourced countries. The emphasis on communicable and endemic diseases influencing the diagnosis and treatment of JIA serves as a valuable addition to existing JIA guidelines. With increasing globalization, these recommendations as a whole provide educational and clinical utility for clinicians worldwide. The low evidence base for our recommendations reflects a shortage of research specific to less resourced countries and serves as an impetus for further inquiry towards optimizing care for children with JIA around the world.
- Published
- 2019
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